Publication Information

{'id': 'https://openalex.org/W2991231801', 'doi': 'https://doi.org/10.1017/neu.2019.47', 'title': 'In major depression, increased kappa and mu opioid receptor levels are associated with immune activation', 'display_name': 'In major depression, increased kappa and mu opioid receptor levels are associated with immune activation', 'publication_year': 2019, 'publication_date': '2019-11-22', 'ids': {'openalex': 'https://openalex.org/W2991231801', 'doi': 'https://doi.org/10.1017/neu.2019.47', 'mag': '2991231801', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31753054'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1017/neu.2019.47', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S173281865', 'display_name': 'Acta Neuropsychiatrica', 'issn_l': '0924-2708', 'issn': ['0924-2708', '1601-5215'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311721', 'host_organization_name': 'Cambridge University Press', 'host_organization_lineage': ['https://openalex.org/P4310311721', 'https://openalex.org/P4310311702'], 'host_organization_lineage_names': ['Cambridge University Press', 'University of Cambridge'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081924790', 'display_name': 'Hussein Kadhem Al‐Hakeim', 'orcid': 'https://orcid.org/0000-0001-6143-5196'}, 'institutions': [{'id': 'https://openalex.org/I47229656', 'display_name': 'University of Kufa', 'ror': 'https://ror.org/02dwrdh81', 'country_code': 'IQ', 'type': 'education', 'lineage': ['https://openalex.org/I47229656']}], 'countries': ['IQ'], 'is_corresponding': False, 'raw_author_name': 'Hussein Kadhem Al-Hakeim', 'raw_affiliation_strings': ['Department of Chemistry, College of Science, University of Kufa, Kufa, Iraq'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, College of Science, University of Kufa, Kufa, Iraq', 'institution_ids': ['https://openalex.org/I47229656']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071130304', 'display_name': 'Suhaer Zeki Al-Fadhel', 'orcid': 'https://orcid.org/0000-0001-9339-3904'}, 'institutions': [{'id': 'https://openalex.org/I47229656', 'display_name': 'University of Kufa', 'ror': 'https://ror.org/02dwrdh81', 'country_code': 'IQ', 'type': 'education', 'lineage': ['https://openalex.org/I47229656']}], 'countries': ['IQ'], 'is_corresponding': False, 'raw_author_name': 'Suhaer Zeki Al-Fadhel', 'raw_affiliation_strings': ['Department of Clinical Laboratory Sciences, College of Pharmacy, University of Kufa, Kufa, Iraq'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Laboratory Sciences, College of Pharmacy, University of Kufa, Kufa, Iraq', 'institution_ids': ['https://openalex.org/I47229656']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112705380', 'display_name': 'Arafat Hussein Al-Dujaili', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47229656', 'display_name': 'University of Kufa', 'ror': 'https://ror.org/02dwrdh81', 'country_code': 'IQ', 'type': 'education', 'lineage': ['https://openalex.org/I47229656']}], 'countries': ['IQ'], 'is_corresponding': False, 'raw_author_name': 'Arafat Hussein Al-Dujaili', 'raw_affiliation_strings': ['Faculty of Medicine, University of Kufa, Kufa, Iraq'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Medicine, University of Kufa, Kufa, Iraq', 'institution_ids': ['https://openalex.org/I47229656']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5032880777', 'display_name': 'Michaël Maes', 'orcid': 'https://orcid.org/0000-0002-2012-871X'}, 'institutions': [{'id': 'https://openalex.org/I158708052', 'display_name': 'Chulalongkorn University', 'ror': 'https://ror.org/028wp3y58', 'country_code': 'TH', 'type': 'education', 'lineage': ['https://openalex.org/I158708052']}, {'id': 'https://openalex.org/I149704539', 'display_name': 'Deakin University', 'ror': 'https://ror.org/02czsnj07', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I149704539']}, {'id': 'https://openalex.org/I2801117330', 'display_name': 'Medical University Plovdiv', 'ror': 'https://ror.org/02kzxd152', 'country_code': 'BG', 'type': 'education', 'lineage': ['https://openalex.org/I2801117330']}], 'countries': ['AU', 'BG', 'TH'], 'is_corresponding': True, 'raw_author_name': 'Michael Maes', 'raw_affiliation_strings': ['Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand', 'Department of Psychiatry, Medical University Plovdiv, Plovdiv, Bulgaria', 'IMPACT Research Center, Deakin University, Geelong, Australia'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand', 'institution_ids': ['https://openalex.org/I158708052']}, {'raw_affiliation_string': 'IMPACT Research Center, Deakin University, Geelong, Australia', 'institution_ids': ['https://openalex.org/I149704539']}, {'raw_affiliation_string': 'Department of Psychiatry, Medical University Plovdiv, Plovdiv, Bulgaria', 'institution_ids': ['https://openalex.org/I2801117330']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5032880777'], 'corresponding_institution_ids': ['https://openalex.org/I158708052', 'https://openalex.org/I149704539', 'https://openalex.org/I2801117330'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.573, 'has_fulltext': False, 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.714746, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '32', 'issue': '2', 'first_page': '99', 'last_page': '108'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11337', 'display_name': 'Tryptophan and brain disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2803', 'display_name': 'Biological Psychiatry'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11337', 'display_name': 'Tryptophan and brain disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2803', 'display_name': 'Biological Psychiatry'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10529', 'display_name': 'Stress Responses and Cortisol', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2802', 'display_name': 'Behavioral Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11541', 'display_name': 'Neuroendocrine regulation and behavior', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/3207', 'display_name': 'Social Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dynorphin', 'display_name': 'Dynorphin', 'score': 0.97889555}, {'id': 'https://openalex.org/keywords/κ-opioid-receptor', 'display_name': 'κ-opioid receptor', 'score': 0.86392236}, {'id': 'https://openalex.org/keywords/dynorphin-a', 'display_name': 'Dynorphin A', 'score': 0.6569214}, {'id': 'https://openalex.org/keywords/μ-opioid-receptor', 'display_name': 'μ-opioid receptor', 'score': 0.4347957}, {'id': 'https://openalex.org/keywords/depression', 'display_name': 'Depression', 'score': 0.41107255}], 'concepts': [{'id': 'https://openalex.org/C151077648', 'wikidata': 'https://www.wikidata.org/wiki/Q324076', 'display_name': 'Dynorphin', 'level': 5, 'score': 0.97889555}, {'id': 'https://openalex.org/C184389661', 'wikidata': 'https://www.wikidata.org/wiki/Q14897645', 'display_name': 'κ-opioid receptor', 'level': 4, 'score': 0.86392236}, {'id': 'https://openalex.org/C2781181269', 'wikidata': 'https://www.wikidata.org/wiki/Q5319233', 'display_name': 'Dynorphin A', 'level': 5, 'score': 0.6569214}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.61374784}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5668034}, {'id': 'https://openalex.org/C2780051608', 'wikidata': 'https://www.wikidata.org/wiki/Q42844', 'display_name': 'Major depressive disorder', 'level': 3, 'score': 0.51505065}, {'id': 'https://openalex.org/C2781063702', 'wikidata': 'https://www.wikidata.org/wiki/Q427523', 'display_name': 'Opioid', 'level': 3, 'score': 0.49988437}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.49307558}, {'id': 'https://openalex.org/C88016717', 'wikidata': 'https://www.wikidata.org/wiki/Q417189', 'display_name': 'Opioid peptide', 'level': 4, 'score': 0.46631062}, {'id': 'https://openalex.org/C2780733359', 'wikidata': 'https://www.wikidata.org/wiki/Q331769', 'display_name': 'Mood', 'level': 2, 'score': 0.43766764}, {'id': 'https://openalex.org/C14397066', 'wikidata': 'https://www.wikidata.org/wiki/Q14911924', 'display_name': 'μ-opioid receptor', 'level': 4, 'score': 0.4347957}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.43005618}, {'id': 'https://openalex.org/C2777134132', 'wikidata': 'https://www.wikidata.org/wiki/Q188638', 'display_name': 'Mood disorders', 'level': 3, 'score': 0.42861593}, {'id': 'https://openalex.org/C2779886867', 'wikidata': 'https://www.wikidata.org/wiki/Q421797', 'display_name': 'Opioid receptor', 'level': 4, 'score': 0.41500953}, {'id': 'https://openalex.org/C2776867660', 'wikidata': 'https://www.wikidata.org/wiki/Q1814941', 'display_name': 'Depression (economics)', 'level': 2, 'score': 0.41107255}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.38697293}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.38593593}, {'id': 'https://openalex.org/C2779144063', 'wikidata': 'https://www.wikidata.org/wiki/Q338924', 'display_name': 'Amygdala', 'level': 2, 'score': 0.23034629}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.15743756}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.14236724}, {'id': 'https://openalex.org/C558461103', 'wikidata': 'https://www.wikidata.org/wiki/Q154430', 'display_name': 'Anxiety', 'level': 2, 'score': 0.13885623}, {'id': 'https://openalex.org/C139719470', 'wikidata': 'https://www.wikidata.org/wiki/Q39680', 'display_name': 'Macroeconomics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C162324750', 'wikidata': 'https://www.wikidata.org/wiki/Q8134', 'display_name': 'Economics', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003865', 'descriptor_name': 'Depressive Disorder, Major', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D003865', 'descriptor_name': 'Depressive Disorder, Major', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D017473', 'descriptor_name': 'Receptors, Opioid, kappa', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D017450', 'descriptor_name': 'Receptors, Opioid, mu', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003865', 'descriptor_name': 'Depressive Disorder, Major', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016753', 'descriptor_name': 'Interleukin-10', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017473', 'descriptor_name': 'Receptors, Opioid, kappa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017450', 'descriptor_name': 'Receptors, Opioid, mu', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1017/neu.2019.47', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S173281865', 'display_name': 'Acta Neuropsychiatrica', 'issn_l': '0924-2708', 'issn': ['0924-2708', '1601-5215'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311721', 'host_organization_name': 'Cambridge University Press', 'host_organization_lineage': ['https://openalex.org/P4310311721', 'https://openalex.org/P4310311702'], 'host_organization_lineage_names': ['Cambridge University Press', 'University of Cambridge'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31753054', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.84, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 87, 'referenced_works': ['https://openalex.org/W1438944313', 'https://openalex.org/W1834168775', 'https://openalex.org/W1944892583', 'https://openalex.org/W1949191280', 'https://openalex.org/W1963627122', 'https://openalex.org/W1967029537', 'https://openalex.org/W1968398347', 'https://openalex.org/W1969314851', 'https://openalex.org/W1972470278', 'https://openalex.org/W1975064257', 'https://openalex.org/W1977266070', 'https://openalex.org/W1979031324', 'https://openalex.org/W1983754627', 'https://openalex.org/W1986194711', 'https://openalex.org/W1989482492', 'https://openalex.org/W1992144053', 'https://openalex.org/W1992545822', 'https://openalex.org/W1994597071', 'https://openalex.org/W1998932539', 'https://openalex.org/W2001530875', 'https://openalex.org/W2003623943', 'https://openalex.org/W2004618736', 'https://openalex.org/W2006027316', 'https://openalex.org/W2007376383', 'https://openalex.org/W2010103733', 'https://openalex.org/W2016119431', 'https://openalex.org/W2017477172', 'https://openalex.org/W2022903755', 'https://openalex.org/W2027249667', 'https://openalex.org/W2028351745', 'https://openalex.org/W2029507624', 'https://openalex.org/W2029584624', 'https://openalex.org/W2035981398', 'https://openalex.org/W2036517132', 'https://openalex.org/W2038069426', 'https://openalex.org/W2040209892', 'https://openalex.org/W2048174914', 'https://openalex.org/W2052933384', 'https://openalex.org/W2057518072', 'https://openalex.org/W2062106032', 'https://openalex.org/W2065603233', 'https://openalex.org/W2066997654', 'https://openalex.org/W2068270366', 'https://openalex.org/W2069612097', 'https://openalex.org/W2071801806', 'https://openalex.org/W2072955178', 'https://openalex.org/W2090564875', 'https://openalex.org/W2090689542', 'https://openalex.org/W2090773348', 'https://openalex.org/W2090804691', 'https://openalex.org/W2104669746', 'https://openalex.org/W2120658378', 'https://openalex.org/W2123799440', 'https://openalex.org/W2123851781', 'https://openalex.org/W2126888123', 'https://openalex.org/W2128577249', 'https://openalex.org/W2129143684', 'https://openalex.org/W2131334660', 'https://openalex.org/W2132167284', 'https://openalex.org/W2137830721', 'https://openalex.org/W2148369021', 'https://openalex.org/W2151349433', 'https://openalex.org/W2158151282', 'https://openalex.org/W2158262405', 'https://openalex.org/W2164978865', 'https://openalex.org/W2168010332', 'https://openalex.org/W2171529630', 'https://openalex.org/W2397405373', 'https://openalex.org/W2420895859', 'https://openalex.org/W2511756370', 'https://openalex.org/W2582903515', 'https://openalex.org/W2591401337', 'https://openalex.org/W2606868341', 'https://openalex.org/W2773099978', 'https://openalex.org/W2795595304', 'https://openalex.org/W2796284997', 'https://openalex.org/W2799790315', 'https://openalex.org/W2807669085', 'https://openalex.org/W2810498355', 'https://openalex.org/W2811012676', 'https://openalex.org/W2883309132', 'https://openalex.org/W2899396191', 'https://openalex.org/W2913803809', 'https://openalex.org/W2947934375', 'https://openalex.org/W4253384824', 'https://openalex.org/W581977681', 'https://openalex.org/W79694293'], 'related_works': ['https://openalex.org/W2938871845', 'https://openalex.org/W2542749714', 'https://openalex.org/W2333462056', 'https://openalex.org/W2331456803', 'https://openalex.org/W2271903968', 'https://openalex.org/W2145721166', 'https://openalex.org/W2138928848', 'https://openalex.org/W2019967851', 'https://openalex.org/W1994991608', 'https://openalex.org/W1986915209'], 'abstract_inverted_index': {'This': [0], 'study': [1, 40], 'was': [2], 'carried': [3], 'out': [4], 'to': [5, 74, 194], 'delineate': [6], 'differences': [7], 'between': [8], 'major': [9], 'depressive': [10], 'disorder': [11], '(MDD)': [12], 'and': [13, 18, 36, 48, 57, 65, 82, 88, 96, 102, 155, 158, 180, 185, 191], 'healthy': [14, 60], 'controls': [15, 113], 'in': [16, 24, 28, 50, 70, 78, 134, 143, 165], 'dynorphin': [17], 'kappa': [19], 'opioid': [20, 33, 161], 'receptor': [21, 34], '(KOR)': [22], 'levels': [23], 'association': [25], 'with': [26, 55, 93, 114, 136, 149], 'changes': [27], 'the': [29, 79, 122, 166, 176], 'β-endorphin': [30, 64], '-': [31], 'mu': [32], '(MOR)': [35], 'immune-inflammatory': [37], 'system.The': [38], 'present': [39], 'examines': [41], 'dynorphin,': [42, 62], 'KOR,': [43, 63], 'β-endorphin,': [44, 100], 'MOR,': [45], 'interleukin': [46], '(IL)-6': [47], 'IL-10': [49, 97], '60': [51], 'drug-free': [52], 'male': [53], 'participants': [54], 'MDD': [56, 71, 111], '30': [58], 'age-matched': [59], 'males.Serum': [61], 'MOR': [66], 'are': [67, 85, 89], 'significantly': [68, 86, 132], 'higher': [69], 'as': [72, 187, 189], 'compared': [73], 'controls.': [75], 'The': [76, 128], 'increases': [77], 'dynorphin/KOR': [80, 129, 154], 'system': [81, 84, 130], 'β-endorphin/MOR': [83, 156], 'intercorrelated': [87], 'both': [90, 103], 'strongly': [91], 'associated': [92, 148], 'increased': [94], 'IL-6': [95], 'levels.': [98], 'Dynorphin,': [99], 'KOR': [101], 'cytokines': [104], 'showed': [105], 'a': [106, 115, 150], 'good': [107], 'diagnostic': [108], 'performance': [109], 'for': [110], 'versus': [112], 'bootstrapped': [116], '(n': [117], '=': [118], '2000)': [119], 'area': [120], 'under': [121], 'receiver': [123], 'operating': [124], 'curve': [125], 'of': [126, 153, 168], '0.972.': [127], 'is': [131, 147], 'decreased': [133], 'depression': [135, 169], 'comorbid': [137], 'nicotine': [138], 'dependence.Our': [139], 'findings': [140], 'suggest': [141], 'that,': [142], 'MDD,': [144], 'immune': [145, 178], 'activation': [146, 152], 'simultaneous': [151], 'signaling': [157], 'that': [159], 'these': [160], 'systems': [162], 'may': [163], 'participate': [164], 'pathophysiology': [167], 'by': [170], '(a)': [171], 'exerting': [172], 'immune-regulatory': [173], 'activities': [174], 'attenuating': [175], 'primary': [177], 'response': [179], '(b)': [181], 'modulating': [182], 'reward': [183], 'responses': [184, 193], 'mood': [186], 'well': [188], 'emotional': [190], 'behavioural': [192], 'stress.': [195]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2991231801', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 4}], 'updated_date': '2025-01-07T08:51:29.239878', 'created_date': '2019-12-05'}