Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2991133785', 'doi': 'https://doi.org/10.1101/854463', 'title': 'Transient Nodal signalling in left precursors coordinates opposed asymmetries shaping the heart loop', 'display_name': 'Transient Nodal signalling in left precursors coordinates opposed asymmetries shaping the heart loop', 'publication_year': 2019, 'publication_date': '2019-11-25', 'ids': {'openalex': 'https://openalex.org/W2991133785', 'doi': 'https://doi.org/10.1101/854463', 'mag': '2991133785'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/854463', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2019/11/25/854463.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2019/11/25/854463.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080989607', 'display_name': 'Audrey Desgrange', 'orcid': 'https://orcid.org/0000-0001-9716-755X'}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I110736937', 'display_name': 'Délégation Paris 5', 'ror': 'https://ror.org/02e0y6e06', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210165077', 'display_name': 'Institut des Maladies Génétiques Imagine', 'ror': 'https://ror.org/05rq3rb55', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210100892', 'https://openalex.org/I4210165077']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Audrey Desgrange', 'raw_affiliation_strings': ['INSERM UMR1163, 75015 Paris, France', 'Imagine -Institut Pasteur, Laboratory of Heart Morphogenesis, 7505 Paris, France', 'Université Paris Descartes, 75006 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Imagine -Institut Pasteur, Laboratory of Heart Morphogenesis, 7505 Paris, France', 'institution_ids': ['https://openalex.org/I157536573', 'https://openalex.org/I4210165077']}, {'raw_affiliation_string': 'Université Paris Descartes, 75006 Paris, France', 'institution_ids': ['https://openalex.org/I110736937', 'https://openalex.org/I204730241']}, {'raw_affiliation_string': 'INSERM UMR1163, 75015 Paris, France', 'institution_ids': ['https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065106798', 'display_name': 'Jean‐François Le Garrec', 'orcid': 'https://orcid.org/0000-0002-2069-0251'}, 'institutions': [{'id': 'https://openalex.org/I4210165077', 'display_name': 'Institut des Maladies Génétiques Imagine', 'ror': 'https://ror.org/05rq3rb55', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210100892', 'https://openalex.org/I4210165077']}, {'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I110736937', 'display_name': 'Délégation Paris 5', 'ror': 'https://ror.org/02e0y6e06', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jean-François Le Garrec', 'raw_affiliation_strings': ['INSERM UMR1163, 75015 Paris, France', 'Imagine -Institut Pasteur, Laboratory of Heart Morphogenesis, 7505 Paris, France', 'Université Paris Descartes, 75006 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Imagine -Institut Pasteur, Laboratory of Heart Morphogenesis, 7505 Paris, France', 'institution_ids': ['https://openalex.org/I4210165077', 'https://openalex.org/I157536573']}, {'raw_affiliation_string': 'Université Paris Descartes, 75006 Paris, France', 'institution_ids': ['https://openalex.org/I110736937', 'https://openalex.org/I204730241']}, {'raw_affiliation_string': 'INSERM UMR1163, 75015 Paris, France', 'institution_ids': ['https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047447454', 'display_name': 'Ségolène Bernheim', 'orcid': 'https://orcid.org/0000-0003-3506-6184'}, 'institutions': [{'id': 'https://openalex.org/I4210165077', 'display_name': 'Institut des Maladies Génétiques Imagine', 'ror': 'https://ror.org/05rq3rb55', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210100892', 'https://openalex.org/I4210165077']}, {'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I110736937', 'display_name': 'Délégation Paris 5', 'ror': 'https://ror.org/02e0y6e06', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Ségolène Bernheim', 'raw_affiliation_strings': ['INSERM UMR1163, 75015 Paris, France', 'Imagine -Institut Pasteur, Laboratory of Heart Morphogenesis, 7505 Paris, France', 'Université Paris Descartes, 75006 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Imagine -Institut Pasteur, Laboratory of Heart Morphogenesis, 7505 Paris, France', 'institution_ids': ['https://openalex.org/I4210165077', 'https://openalex.org/I157536573']}, {'raw_affiliation_string': 'Université Paris Descartes, 75006 Paris, France', 'institution_ids': ['https://openalex.org/I110736937', 'https://openalex.org/I204730241']}, {'raw_affiliation_string': 'INSERM UMR1163, 75015 Paris, France', 'institution_ids': ['https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028812145', 'display_name': 'Tobias Holm Bønnelykke', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210165077', 'display_name': 'Institut des Maladies Génétiques Imagine', 'ror': 'https://ror.org/05rq3rb55', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210100892', 'https://openalex.org/I4210165077']}, {'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I110736937', 'display_name': 'Délégation Paris 5', 'ror': 'https://ror.org/02e0y6e06', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I182627622', 'display_name': 'Université Sorbonne Nouvelle', 'ror': 'https://ror.org/03z6jp965', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I182627622']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Tobias Holm Bønnelykke', 'raw_affiliation_strings': ['INSERM UMR1163, 75015 Paris, France', 'Imagine -Institut Pasteur, Laboratory of Heart Morphogenesis, 7505 Paris, France', 'Sorbonne Université, Collège Doctoral, 75005 Paris, France', 'Université Paris Descartes, 75006 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Imagine -Institut Pasteur, Laboratory of Heart Morphogenesis, 7505 Paris, France', 'institution_ids': ['https://openalex.org/I4210165077', 'https://openalex.org/I157536573']}, {'raw_affiliation_string': 'Sorbonne Université, Collège Doctoral, 75005 Paris, France', 'institution_ids': ['https://openalex.org/I39804081', 'https://openalex.org/I182627622']}, {'raw_affiliation_string': 'INSERM UMR1163, 75015 Paris, France', 'institution_ids': ['https://openalex.org/I154526488']}, {'raw_affiliation_string': 'Université Paris Descartes, 75006 Paris, France', 'institution_ids': ['https://openalex.org/I110736937', 'https://openalex.org/I204730241']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082778843', 'display_name': 'Sigolène M. Meilhac', 'orcid': 'https://orcid.org/0000-0003-4080-2617'}, 'institutions': [{'id': 'https://openalex.org/I4210165077', 'display_name': 'Institut des Maladies Génétiques Imagine', 'ror': 'https://ror.org/05rq3rb55', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210100892', 'https://openalex.org/I4210165077']}, {'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I110736937', 'display_name': 'Délégation Paris 5', 'ror': 'https://ror.org/02e0y6e06', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I110736937', 'https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Sigolène M. Meilhac', 'raw_affiliation_strings': ['INSERM UMR1163, 75015 Paris, France', 'Imagine -Institut Pasteur, Laboratory of Heart Morphogenesis, 7505 Paris, France', 'Université Paris Descartes, 75006 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Imagine -Institut Pasteur, Laboratory of Heart Morphogenesis, 7505 Paris, France', 'institution_ids': ['https://openalex.org/I4210165077', 'https://openalex.org/I157536573']}, {'raw_affiliation_string': 'Université Paris Descartes, 75006 Paris, France', 'institution_ids': ['https://openalex.org/I110736937', 'https://openalex.org/I204730241']}, {'raw_affiliation_string': 'INSERM UMR1163, 75015 Paris, France', 'institution_ids': ['https://openalex.org/I154526488']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5082778843'], 'corresponding_institution_ids': ['https://openalex.org/I4210165077', 'https://openalex.org/I157536573', 'https://openalex.org/I110736937', 'https://openalex.org/I204730241', 'https://openalex.org/I154526488'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.552351, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 62, 'max': 70}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11677', 'display_name': 'Molecular Mechanisms of Cardiac Development and Regeneration', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11677', 'display_name': 'Molecular Mechanisms of Cardiac Development and Regeneration', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10268', 'display_name': 'Notch Signaling Pathway in Development and Disease', 'score': 0.9838, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nodal-signaling', 'display_name': 'Nodal signaling', 'score': 0.6568339}, {'id': 'https://openalex.org/keywords/organogenesis', 'display_name': 'Organogenesis', 'score': 0.56423545}, {'id': 'https://openalex.org/keywords/notch-signaling', 'display_name': 'Notch Signaling', 'score': 0.475797}], 'concepts': [{'id': 'https://openalex.org/C83330619', 'wikidata': 'https://www.wikidata.org/wiki/Q21124872', 'display_name': 'NODAL', 'level': 2, 'score': 0.98034763}, {'id': 'https://openalex.org/C205583638', 'wikidata': 'https://www.wikidata.org/wiki/Q7046607', 'display_name': 'Nodal signaling', 'level': 5, 'score': 0.6568339}, {'id': 'https://openalex.org/C40692019', 'wikidata': 'https://www.wikidata.org/wiki/Q815547', 'display_name': 'Morphogenesis', 'level': 3, 'score': 0.58822167}, {'id': 'https://openalex.org/C30503417', 'wikidata': 'https://www.wikidata.org/wiki/Q958938', 'display_name': 'Organogenesis', 'level': 3, 'score': 0.56423545}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5338567}, {'id': 'https://openalex.org/C51785407', 'wikidata': 'https://www.wikidata.org/wiki/Q2627568', 'display_name': 'Effector', 'level': 2, 'score': 0.46807253}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4661701}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.40189803}, {'id': 'https://openalex.org/C87073359', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryogenesis', 'level': 3, 'score': 0.13789555}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.1272586}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.12630546}, {'id': 'https://openalex.org/C129536746', 'wikidata': 'https://www.wikidata.org/wiki/Q1141026', 'display_name': 'Gastrulation', 'level': 4, 'score': 0.096613795}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08578864}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/854463', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2019/11/25/854463.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/854463', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2019/11/25/854463.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 87, 'referenced_works': ['https://openalex.org/W1526366124', 'https://openalex.org/W1599764229', 'https://openalex.org/W1662926935', 'https://openalex.org/W1853058099', 'https://openalex.org/W1871182286', 'https://openalex.org/W1902236642', 'https://openalex.org/W1905104097', 'https://openalex.org/W1926307205', 'https://openalex.org/W1965271063', 'https://openalex.org/W1965902274', 'https://openalex.org/W1970385199', 'https://openalex.org/W1970798233', 'https://openalex.org/W1975759852', 'https://openalex.org/W1976306783', 'https://openalex.org/W1989723819', 'https://openalex.org/W1990414447', 'https://openalex.org/W1990461522', 'https://openalex.org/W2001448821', 'https://openalex.org/W2002732720', 'https://openalex.org/W2004559089', 'https://openalex.org/W2006028524', 'https://openalex.org/W2011035258', 'https://openalex.org/W2017497088', 'https://openalex.org/W2018838175', 'https://openalex.org/W2018995349', 'https://openalex.org/W2020352822', 'https://openalex.org/W2022992789', 'https://openalex.org/W2036233315', 'https://openalex.org/W2037947871', 'https://openalex.org/W2049309679', 'https://openalex.org/W2049884609', 'https://openalex.org/W2053680680', 'https://openalex.org/W2056824123', 'https://openalex.org/W2059693655', 'https://openalex.org/W2065528132', 'https://openalex.org/W2065818609', 'https://openalex.org/W2067658938', 'https://openalex.org/W2074292609', 'https://openalex.org/W2077557886', 'https://openalex.org/W2081967573', 'https://openalex.org/W2083664734', 'https://openalex.org/W2083904901', 'https://openalex.org/W2084105838', 'https://openalex.org/W2084868598', 'https://openalex.org/W2084972992', 'https://openalex.org/W2085221145', 'https://openalex.org/W2086768503', 'https://openalex.org/W2090596888', 'https://openalex.org/W2097836010', 'https://openalex.org/W2099023864', 'https://openalex.org/W2100326113', 'https://openalex.org/W2101450485', 'https://openalex.org/W2103899656', 'https://openalex.org/W2111634405', 'https://openalex.org/W2115927769', 'https://openalex.org/W2120195060', 'https://openalex.org/W2120410199', 'https://openalex.org/W2127522049', 'https://openalex.org/W2129835280', 'https://openalex.org/W2138053255', 'https://openalex.org/W2140197843', 'https://openalex.org/W2147165377', 'https://openalex.org/W2150288232', 'https://openalex.org/W2151484485', 'https://openalex.org/W2155582359', 'https://openalex.org/W2159527276', 'https://openalex.org/W2161651776', 'https://openalex.org/W2161821489', 'https://openalex.org/W2168679271', 'https://openalex.org/W2416845977', 'https://openalex.org/W2484791469', 'https://openalex.org/W2487030156', 'https://openalex.org/W2555626725', 'https://openalex.org/W2556548281', 'https://openalex.org/W2557927839', 'https://openalex.org/W2587025440', 'https://openalex.org/W2605233139', 'https://openalex.org/W2606030880', 'https://openalex.org/W2741887047', 'https://openalex.org/W2745856030', 'https://openalex.org/W2750910159', 'https://openalex.org/W2768527499', 'https://openalex.org/W2889401588', 'https://openalex.org/W2901098096', 'https://openalex.org/W2949369039', 'https://openalex.org/W3038114054', 'https://openalex.org/W610887637'], 'related_works': ['https://openalex.org/W260713505', 'https://openalex.org/W2095762981', 'https://openalex.org/W2092088384', 'https://openalex.org/W2067642760', 'https://openalex.org/W2066025963', 'https://openalex.org/W2050415715', 'https://openalex.org/W2005829082', 'https://openalex.org/W1995473388', 'https://openalex.org/W1984835532', 'https://openalex.org/W1568774846'], 'abstract_inverted_index': {'Summary': [0], 'The': [1], 'secreted': [2], 'factor': [3], 'Nodal': [4, 36, 61, 92, 126, 146], 'has': [5, 28], 'been': [6], 'shown': [7], 'to': [8, 65, 103], 'be': [9], 'a': [10, 73, 95, 117], 'major': [11], 'left': [12], 'determinant.': [13], 'Although': [14], 'it': [15, 100], 'is': [16, 37, 62, 80, 101], 'associated': [17], 'with': [18], 'severe': [19], 'congenital': [20], 'heart': [21, 26, 45, 53, 112], 'defects,': [22], 'its': [23], 'role': [24], 'in': [25, 40, 130], 'morphogenesis': [27], 'remained': [29], 'poorly': [30], 'understood.': [31], 'Here,': [32], 'we': [33, 58, 89], 'report': [34], 'that': [35, 60, 79, 91], 'transiently': [38], 'active': [39], 'precursors': [41], 'of': [42, 52, 72, 77, 82, 97, 125], 'the': [43, 49, 111], 'mouse': [44], 'tube': [46, 113], 'poles,': [47, 114], 'before': [48], 'morphological': [50], 'changes': [51], 'looping.': [54], 'In': [55], 'conditional': [56], 'mutants,': [57], 'show': [59], 'not': [63], 'required': [64, 102], 'initiate': [66], 'asymmetric': [67, 148], 'morphogenesis.': [68], 'We': [69, 121], 'provide': [70], 'evidence': [71], 'heart-specific': [74], 'random': [75], 'generator': [76], 'asymmetry': [78], 'independent': [81], 'Nodal.': [83], 'Using': [84], '3D': [85], 'quantifications': [86], 'and': [87, 105, 135], 'simulations,': [88], 'demonstrate': [90], 'functions': [93], 'as': [94], 'bias': [96], 'this': [98], 'mechanism:': [99], 'amplify': [104], 'coordinate': [106], 'opposed': [107], 'left-right': [108], 'asymmetries': [109, 129], 'at': [110], 'thus': [115], 'generating': [116], 'robust': [118], 'helical': [119], 'shape.': [120], 'identify': [122], 'downstream': [123], 'effectors': [124], 'signalling,': [127], 'regulating': [128], 'cell': [131, 133], 'proliferation,': [132], 'differentiation': [134], 'extra-cellular': [136], 'matrix': [137], 'composition.': [138], 'Our': [139], 'work': [140], 'provides': [141], 'novel': [142], 'insight': [143], 'into': [144], 'how': [145], 'regulates': [147], 'organogenesis.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2991133785', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-09-18T04:15:06.351080', 'created_date': '2019-12-05'}