Mitochondrial DNA Methylation in Boilermaker Construction Workers Exposed to Metal Particulates

Name: Work Video:
Duration: 3 min 30 s
Hyang‐Min Byun; Elena Colicino; Tianteng Fan; David C. Christiani; Andrea Baccarelli
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[8, 121, 135, 149, 169, 236], 'Metal': [9], 'ParticulatesAbstract': [10], 'Number:2529': [11], 'Hyang-Min': [12, 25], 'Byun*,': [13], 'Elena': [14, 39], 'Colicino,': [15], 'Tianteng': [16, 53], 'Fan,': [17], 'David': [18, 67], 'C.': [19, 68], 'Christiani,': [20], 'and': [21, 82, 116, 147, 185, 195, 270, 315], 'Andrea': [22, 83], 'A.': [23, 84], 'Baccarelli': [24, 85], 'Byun*': [26], 'Harvard': [27, 41, 55, 70, 86], 'School': [28, 42, 56, 71, 87], 'of': [29, 43, 57, 72, 88, 103, 131, 167, 244, 250], 'Public': [30, 44, 58, 73, 89], 'Health,': [31, 45, 59, 74, 90], 'United': [32, 46, 60, 75, 91], 'States,': [33, 47, 61, 76, 92], 'E-mail': [34, 48, 62, 77, 93], 'Address:': [35, 49, 63, 78, 94], '[email': [36, 50, 64, 79, 95], 'protected]': [37, 51, 65, 80, 96], ',': [38, 52, 66, 81], 'Colicino': [40], 'Fan': [54], 'Christiani': [69], 'AbstractBackground:': [97], 'Mitochondria': [98], 'have': [99], 'double-stranded': [100], 'circular': [101], 'form': [102], '16.6': [104], 'kb': [105], 'mitochondrial': [106, 145], '(mtDNA),': [108], 'which': [109], 'is': [110, 127], 'independent': [111], 'from': [112, 172, 344], 'the': [113, 128, 165, 179, 216, 230, 242, 248, 286], 'nuclear': [114], 'uses': [117], 'separate': [118], 'epigenetic': [119], 'machinery': [120], 'generate': [122], 'mtDNA': [123, 139, 153, 176, 180, 261, 294], 'methylation.': [124], 'The': [125, 273], 'mitochondrion': [126], 'primary': [129], 'target': [130], 'oxidative-stress': [132], 'response': [134], 'exogenous': [136], 'environments.': [137], 'Damaged': [138], 'by': [140, 247, 258], 'oxidative': [141], 'stress': [142], 'can': [143], 'cause': [144], 'dysfunction': [146], 'lead': [148], 'human': [150], 'disease.': [151], 'However,': [152], 'methylation': [154, 177, 257, 295, 317, 331], 'has': [155], 'been': [156], 'largely': [157], 'overlooked': [158], 'environmental': [160], 'studies.': [161], 'Aims:': [162], 'To': [163], 'examine': [164], 'association': [166], 'exposure': [168, 235, 276, 324, 342], 'metal': [170], 'particulates': [171], 'welding': [173, 281, 345], 'with': [174, 302, 321, 339], 'blood': [175], 'promoter': [181, 298, 334], 'region': [182, 299, 335], "('D-": [183], "loop')": [184], 'genes': [186], 'essential': [187], 'for': [188, 267], 'protein': [189], 'synthesis': [190], '[transfer': [191], 'RNA': [192, 198], 'phenylalanine': [193], '(MT-TF)': [194], '12S': [196], 'ribosomal': [197], '(MT-RNR1)': [199], 'genes]': [200], 'boilermaker': [202, 307, 347], 'construction': [203, 308, 348], 'workers.Methods:': [204], 'Fifty-four': [205], 'healthy': [206], 'male': [207], 'participants': [208], 'were': [209, 265], 'recruited': [210], 'on': [211, 332], 'multiple': [212], 'sampling': [213], 'cycles': [214], 'at': [215, 222], 'Union': [218], 'Local': [219], '29,': [220], 'located': [221], 'Quincy,': [223], 'Massachusetts.': [224], 'We': [225, 255], 'measured': [226, 256], 'personal': [227, 237, 288], 'PM2.5': [228, 238, 246, 275, 303, 323, 341], 'background': [231, 287], 'ambient': [232, 340], 'environment.': [233], 'Cumulative': [234], 'was': [239, 277, 300, 318, 336], 'defined': [240], 'as': [241], 'product': [243], 'mean': [245], 'time': [249], 'work': [251, 282], '(average': [252], '5': [253], 'hours).': [254], 'bisulfite-Pyrosequencing': [259], 'regions.': [262], 'All': [263], 'analyses': [264], 'adjusted': [266], 'age,': [268], 'smoking,': [269], 'alcohol': [271], 'assumption.Results:': [272], "participants'": [274], 'significantly': [278], 'higher': [279], 'after': [280], '(mean': [283, 290], '143µg/m3)': [284], 'than': [285], 'level': [289, 305], '40µg/m3,': [291], 'p-value<0.001).': [292], 'Blood': [293], 'D-loop': [297, 333], 'associated': [301, 320, 338], 'accumulation': [304], 'workers': [309], '(ß=-0.29%,': [310], 'p-value=0.003,': [311], '95%': [312, 327], 'CI:-0.48;-0.11).': [313], 'MT-TF': [314], 'MT-RNR1': [316], 'not': [319], 'cumulative': [322], '(ß=-0.10%,': [325], 'p-value=0.63,': [326], 'CI:-0.50;0.30).Conclusions:': [328], 'negatively': [337], 'generated': [343], 'workers.': [349]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2990090729', 'counts_by_year': [], 'updated_date': '2024-12-13T22:47:16.996688', 'created_date': '2019-12-05'}
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