Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2990079676', 'doi': 'https://doi.org/10.1016/j.omtn.2019.11.009', 'title': 'In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation', 'display_name': 'In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation', 'publication_year': 2020, 'publication_date': '2020-03-01', 'ids': {'openalex': 'https://openalex.org/W2990079676', 'doi': 'https://doi.org/10.1016/j.omtn.2019.11.009', 'mag': '2990079676', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31855834', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6926209'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.omtn.2019.11.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764969478', 'display_name': 'Molecular Therapy — Nucleic Acids', 'issn_l': '2162-2531', 'issn': ['2162-2531'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.1016/j.omtn.2019.11.009', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020489302', 'display_name': 'Elena M. Smekalova', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elena M. Smekalova', 'raw_affiliation_strings': ['David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA', 'institution_ids': ['https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066126356', 'display_name': 'Maxim V. Gerashchenko', 'orcid': 'https://orcid.org/0000-0001-8396-2202'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maxim V. Gerashchenko', 'raw_affiliation_strings': ['Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA', 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I1283280774']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071032611', 'display_name': 'Patrick B. F. O’Connor', 'orcid': 'https://orcid.org/0000-0003-1085-2795'}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Patrick B.F. O’Connor', 'raw_affiliation_strings': ['School of Biochemistry and Cell Biology, University College Cork, Cork T12 YN60, Ireland'], 'affiliations': [{'raw_affiliation_string': 'School of Biochemistry and Cell Biology, University College Cork, Cork T12 YN60, Ireland', 'institution_ids': ['https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033580978', 'display_name': 'Charles A. Whittaker', 'orcid': 'https://orcid.org/0000-0002-2400-0094'}, 'institutions': [{'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Charles A. Whittaker', 'raw_affiliation_strings': ['David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA', 'institution_ids': ['https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019835767', 'display_name': 'Kevin Kauffman', 'orcid': 'https://orcid.org/0009-0004-3249-4671'}, 'institutions': [{'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kevin J. Kauffman', 'raw_affiliation_strings': ['David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA', 'institution_ids': ['https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091445484', 'display_name': 'Anna S. Fefilova', 'orcid': 'https://orcid.org/0000-0002-6927-4363'}, 'institutions': [{'id': 'https://openalex.org/I125989756', 'display_name': 'Skolkovo Institute of Science and Technology', 'ror': 'https://ror.org/03f9nc143', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I125989756']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Anna S. Fefilova', 'raw_affiliation_strings': ['Skolkovo Institute of Science and Technology, Skolkovo, Moscow, 121205, Russia'], 'affiliations': [{'raw_affiliation_string': 'Skolkovo Institute of Science and Technology, Skolkovo, Moscow, 121205, Russia', 'institution_ids': ['https://openalex.org/I125989756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000564880', 'display_name': 'Timofei S. Zatsepin', 'orcid': 'https://orcid.org/0000-0003-0030-9174'}, 'institutions': [{'id': 'https://openalex.org/I19880235', 'display_name': 'Lomonosov Moscow State University', 'ror': 'https://ror.org/010pmpe69', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I19880235']}, {'id': 'https://openalex.org/I125989756', 'display_name': 'Skolkovo Institute of Science and Technology', 'ror': 'https://ror.org/03f9nc143', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I125989756']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Timofei S. Zatsepin', 'raw_affiliation_strings': ['Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119234, Russia', 'Skolkovo Institute of Science and Technology, Skolkovo, Moscow, 121205, Russia'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119234, Russia', 'institution_ids': ['https://openalex.org/I19880235']}, {'raw_affiliation_string': 'Skolkovo Institute of Science and Technology, Skolkovo, Moscow, 121205, Russia', 'institution_ids': ['https://openalex.org/I125989756']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035036670', 'display_name': 'Roman L. Bogorad', 'orcid': 'https://orcid.org/0000-0002-4691-1163'}, 'institutions': [{'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Roman L. Bogorad', 'raw_affiliation_strings': ['David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA', 'institution_ids': ['https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047187282', 'display_name': 'Pavel V. Baranov', 'orcid': 'https://orcid.org/0000-0001-9017-0270'}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}, {'id': 'https://openalex.org/I4210105571', 'display_name': 'Institute of Bioorganic Chemistry', 'ror': 'https://ror.org/01dg04253', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I4210105571', 'https://openalex.org/I4210129690']}], 'countries': ['IE', 'RU'], 'is_corresponding': False, 'raw_author_name': 'Pavel V. Baranov', 'raw_affiliation_strings': ['School of Biochemistry and Cell Biology, University College Cork, Cork T12 YN60, Ireland', 'Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow 117997, Russia'], 'affiliations': [{'raw_affiliation_string': 'School of Biochemistry and Cell Biology, University College Cork, Cork T12 YN60, Ireland', 'institution_ids': ['https://openalex.org/I27577105']}, {'raw_affiliation_string': 'Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow 117997, Russia', 'institution_ids': ['https://openalex.org/I4210105571']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042597057', 'display_name': 'Róbert Langer', 'orcid': 'https://orcid.org/0000-0003-4255-0492'}, 'institutions': [{'id': 'https://openalex.org/I4210092658', 'display_name': 'Harvard–MIT Division of Health Sciences and Technology', 'ror': 'https://ror.org/00jjeh629', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210092658']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert Langer', 'raw_affiliation_strings': ['David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA', 'Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA', 'Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA', 'Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA', 'institution_ids': ['https://openalex.org/I4210092658']}, {'raw_affiliation_string': 'David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA', 'institution_ids': ['https://openalex.org/I63966007']}, {'raw_affiliation_string': 'Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA', 'institution_ids': ['https://openalex.org/I63966007']}, {'raw_affiliation_string': 'Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA', 'institution_ids': ['https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010080171', 'display_name': 'Vadim N. Gladyshev', 'orcid': 'https://orcid.org/0000-0002-0372-7016'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vadim N. Gladyshev', 'raw_affiliation_strings': ['Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA', 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036096394', 'display_name': 'Daniel G. Anderson', 'orcid': 'https://orcid.org/0000-0001-5629-4798'}, 'institutions': [{'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}, {'id': 'https://openalex.org/I4210092658', 'display_name': 'Harvard–MIT Division of Health Sciences and Technology', 'ror': 'https://ror.org/00jjeh629', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210092658']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Daniel G. Anderson', 'raw_affiliation_strings': ['David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA', 'Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA', 'Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA', 'Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA', 'institution_ids': ['https://openalex.org/I63966007']}, {'raw_affiliation_string': 'Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA', 'institution_ids': ['https://openalex.org/I63966007']}, {'raw_affiliation_string': 'Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA', 'institution_ids': ['https://openalex.org/I63966007']}, {'raw_affiliation_string': 'Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA', 'institution_ids': ['https://openalex.org/I4210092658']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5036827827', 'display_name': 'Victor Koteliansky', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I125989756', 'display_name': 'Skolkovo Institute of Science and Technology', 'ror': 'https://ror.org/03f9nc143', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I125989756']}], 'countries': ['RU'], 'is_corresponding': True, 'raw_author_name': 'Victor Koteliansky', 'raw_affiliation_strings': ['Skolkovo Institute of Science and Technology, Skolkovo, Moscow, 121205, Russia'], 'affiliations': [{'raw_affiliation_string': 'Skolkovo Institute of Science and Technology, Skolkovo, Moscow, 121205, Russia', 'institution_ids': ['https://openalex.org/I125989756']}]}], 'countries_distinct_count': 3, 'institutions_distinct_count': 8, 'corresponding_author_ids': ['https://openalex.org/A5036096394', 'https://openalex.org/A5036827827'], 'corresponding_institution_ids': ['https://openalex.org/I63966007', 'https://openalex.org/I4210092658', 'https://openalex.org/I125989756'], 'apc_list': {'value': 3900, 'currency': 'USD', 'value_usd': 3900, 'provenance': 'doaj'}, 'apc_paid': {'value': 3900, 'currency': 'USD', 'value_usd': 3900, 'provenance': 'doaj'}, 'fwci': 1.054, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.999982, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '19', 'issue': None, 'first_page': '252', 'last_page': '266'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Role of Long Noncoding RNAs in Cancer and Development', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ribosome-profiling', 'display_name': 'Ribosome profiling', 'score': 0.7094227}, {'id': 'https://openalex.org/keywords/mrna-modification', 'display_name': 'mRNA modification', 'score': 0.557514}, {'id': 'https://openalex.org/keywords/rna-regulation', 'display_name': 'RNA Regulation', 'score': 0.541472}, {'id': 'https://openalex.org/keywords/gene-expression-regulation', 'display_name': 'Gene Expression Regulation', 'score': 0.513968}, {'id': 'https://openalex.org/keywords/ribosome-biogenesis', 'display_name': 'ribosome biogenesis', 'score': 0.510342}, {'id': 'https://openalex.org/keywords/rna-methylation', 'display_name': 'RNA methylation', 'score': 0.507871}, {'id': 'https://openalex.org/keywords/translational-regulation', 'display_name': 'Translational regulation', 'score': 0.45050457}, {'id': 'https://openalex.org/keywords/initiation-factor', 'display_name': 'Initiation factor', 'score': 0.44334033}, {'id': 'https://openalex.org/keywords/ribosomal-protein', 'display_name': 'Ribosomal protein', 'score': 0.42515606}], 'concepts': [{'id': 'https://openalex.org/C2779419633', 'wikidata': 'https://www.wikidata.org/wiki/Q7322423', 'display_name': 'Ribosome biogenesis', 'level': 5, 'score': 0.72201896}, {'id': 'https://openalex.org/C182325514', 'wikidata': 'https://www.wikidata.org/wiki/Q7322425', 'display_name': 'Ribosome profiling', 'level': 5, 'score': 0.7094227}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7073504}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5054388}, {'id': 'https://openalex.org/C149364088', 'wikidata': 'https://www.wikidata.org/wiki/Q185917', 'display_name': 'Translation (biology)', 'level': 4, 'score': 0.5021441}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.5010865}, {'id': 'https://openalex.org/C3675279', 'wikidata': 'https://www.wikidata.org/wiki/Q211935', 'display_name': 'Protein biosynthesis', 'level': 2, 'score': 0.49900365}, {'id': 'https://openalex.org/C39685955', 'wikidata': 'https://www.wikidata.org/wiki/Q3455905', 'display_name': 'Translational regulation', 'level': 5, 'score': 0.45050457}, {'id': 'https://openalex.org/C62493599', 'wikidata': 'https://www.wikidata.org/wiki/Q424137', 'display_name': 'Initiation factor', 'level': 5, 'score': 0.44334033}, {'id': 'https://openalex.org/C38062823', 'wikidata': 'https://www.wikidata.org/wiki/Q3408228', 'display_name': 'Ribosomal protein', 'level': 5, 'score': 0.42515606}, {'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.42465943}, {'id': 'https://openalex.org/C88478588', 'wikidata': 'https://www.wikidata.org/wiki/Q42244', 'display_name': 'Ribosome', 'level': 4, 'score': 0.40039077}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.32781854}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.30848026}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.27317756}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.24842557}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.18083885}], 'mesh': [], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.omtn.2019.11.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764969478', 'display_name': 'Molecular Therapy — Nucleic Acids', 'issn_l': '2162-2531', 'issn': ['2162-2531'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6926209', 'pdf_url': 'https://europepmc.org/articles/pmc6926209?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10147/629978', 'pdf_url': 'https://www.lenus.ie/bitstream/10147/629978/1/mmc3.pdf', 'source': {'id': 'https://openalex.org/S4306401756', 'display_name': 'Lenus, The Irish Health Repository (Dr Steevens Hospital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/1721.1/136581', 'pdf_url': 'https://dspace.mit.edu/bitstream/1721.1/136581/2/1-s2.0-S2162253119303622-main.pdf', 'source': {'id': 'https://openalex.org/S4306400425', 'display_name': 'DSpace@MIT (Massachusetts Institute of Technology)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I63966007', 'host_organization_name': 'Massachusetts Institute of Technology', 'host_organization_lineage': ['https://openalex.org/I63966007'], 'host_organization_lineage_names': ['Massachusetts Institute of Technology'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926209', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31855834', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.omtn.2019.11.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764969478', 'display_name': 'Molecular Therapy — Nucleic Acids', 'issn_l': '2162-2531', 'issn': ['2162-2531'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.81, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320324099', 'funder_display_name': 'Russian Science Foundation', 'award_id': '14-34-00017'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'GM065204'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'DK117149'}], 'datasets': [], 'versions': [], 'referenced_works_count': 65, 'referenced_works': ['https://openalex.org/W1608233475', 'https://openalex.org/W1841794733', 'https://openalex.org/W1967182910', 'https://openalex.org/W1969585647', 'https://openalex.org/W2001915927', 'https://openalex.org/W2004526658', 'https://openalex.org/W2013321787', 'https://openalex.org/W2020099265', 'https://openalex.org/W2021764678', 'https://openalex.org/W2022472106', 'https://openalex.org/W2023324723', 'https://openalex.org/W2027693306', 'https://openalex.org/W2032746619', 'https://openalex.org/W2037313242', 'https://openalex.org/W2039094077', 'https://openalex.org/W2039171339', 'https://openalex.org/W2041157094', 'https://openalex.org/W2045899555', 'https://openalex.org/W2058904982', 'https://openalex.org/W2068256856', 'https://openalex.org/W2071030419', 'https://openalex.org/W2083662151', 'https://openalex.org/W2089150369', 'https://openalex.org/W2089716875', 'https://openalex.org/W2092246783', 'https://openalex.org/W2095432693', 'https://openalex.org/W2096330071', 'https://openalex.org/W2100254450', 'https://openalex.org/W2103666721', 'https://openalex.org/W2110083155', 'https://openalex.org/W2116583464', 'https://openalex.org/W2130410032', 'https://openalex.org/W2139528237', 'https://openalex.org/W2140597716', 'https://openalex.org/W2159482845', 'https://openalex.org/W2161897332', 'https://openalex.org/W2170233132', 'https://openalex.org/W2170781554', 'https://openalex.org/W2171875574', 'https://openalex.org/W2172691879', 'https://openalex.org/W2273444055', 'https://openalex.org/W2288182265', 'https://openalex.org/W2306137721', 'https://openalex.org/W2399308870', 'https://openalex.org/W2402482005', 'https://openalex.org/W2405351790', 'https://openalex.org/W2427010553', 'https://openalex.org/W2480009166', 'https://openalex.org/W2485377503', 'https://openalex.org/W2518959324', 'https://openalex.org/W2520264800', 'https://openalex.org/W2524031466', 'https://openalex.org/W2534849249', 'https://openalex.org/W2591905283', 'https://openalex.org/W2592503616', 'https://openalex.org/W2599268207', 'https://openalex.org/W2611382824', 'https://openalex.org/W2748054224', 'https://openalex.org/W2754443480', 'https://openalex.org/W2755411663', 'https://openalex.org/W2765462681', 'https://openalex.org/W2793800931', 'https://openalex.org/W2795471900', 'https://openalex.org/W2967931898', 'https://openalex.org/W4294216483'], 'related_works': ['https://openalex.org/W2939637177', 'https://openalex.org/W2913622812', 'https://openalex.org/W2749718530', 'https://openalex.org/W2625634747', 'https://openalex.org/W2263587832', 'https://openalex.org/W2140862285', 'https://openalex.org/W2117211763', 'https://openalex.org/W2074258805', 'https://openalex.org/W2056801681', 'https://openalex.org/W2043376129'], 'abstract_inverted_index': {'Translation': [0, 173], 'is': [1, 8, 138, 174, 181, 311], 'an': [2, 175], 'essential': [3, 176], 'biological': [4, 177], 'process,': [5, 178], 'and': [6, 18, 50, 62, 93, 103, 120, 179, 191, 223, 235, 266, 276, 293], 'dysregulation': [7, 24, 180, 197], 'associated': [9, 139, 182, 312], 'with': [10, 140, 183, 313], 'a': [11, 131, 159, 184, 304, 332], 'range': [12, 185], 'of': [13, 34, 75, 90, 107, 112, 117, 142, 158, 168, 186, 207, 248, 263, 280, 285, 290, 315, 331, 341], 'diseases': [14, 187], 'including': [15, 188], 'ribosomopathies,': [16, 189], 'diabetes,': [17, 190], 'cancer.': [19, 192], 'Here,': [20, 193], 'we': [21, 194], 'examine': [22, 195], 'translation': [23, 36, 66, 74, 170, 196, 209, 239, 247, 343], 'in': [25, 40, 64, 72, 97, 125, 134, 146, 150, 161, 171, 198, 213, 237, 245, 270, 298, 307, 319, 323, 334, 344], 'vivo': [26, 162, 199, 335], 'using': [27, 200], 'RNAi': [28, 201], 'to': [29, 58, 127, 202, 231, 300], 'knock': [30, 203], 'down': [31, 204], 'the': [32, 35, 41, 59, 73, 143, 156, 166, 205, 208, 214, 232, 246, 316, 329, 339], 'm-subunit': [33, 206], 'initiation': [37, 210], 'factor': [38, 211], 'eIF3': [39, 212], 'mouse': [42, 215], 'liver.': [43, 216], 'Transcriptome': [44, 217], 'sequencing,': [45, 218], 'ribosome': [46, 86, 108, 219, 259, 281], 'profiling,': [47, 220], 'whole': [48, 221], 'proteome,': [49, 222], 'phosphoproteome': [51, 224], 'analyses': [52, 225], 'show': [53, 226], 'that': [54, 67, 227, 240], 'eIF3m': [55, 128, 135, 228, 301, 308], 'deficiency': [56, 229], 'leads': [57, 230], 'transcriptional': [60, 79, 233, 252], 'response': [61, 80, 126, 234, 253, 299], 'changes': [63, 236], 'cellular': [65, 238], 'yield': [68, 241], 'few': [69, 242], 'detectable': [70, 243], 'differences': [71, 244], 'particular': [76, 249], 'mRNAs.': [77, 250], 'The': [78, 251], 'fell': [81, 254], 'into': [82, 255], 'two': [83, 256], 'main': [84, 257], 'categories:': [85, 258], 'biogenesis': [87, 109, 260, 282], '(increased': [88, 261], 'transcription': [89, 124, 262, 297], 'ribosomal': [91, 121, 264, 294], 'proteins)': [92, 265], 'cell': [94, 267], 'metabolism': [95, 268], '(alterations': [96, 269], 'lipid,': [98, 271], 'amino': [99, 272], 'acid,': [100, 102, 273, 275], 'nucleic': [101, 274], 'drug': [104, 277], 'metabolism).': [105, 278], 'Analysis': [106, 279], 'reveals': [110, 283], 'inhibition': [111, 284], 'rRNA': [113, 118, 286, 291], 'processing,': [114, 287], 'highlighting': [115, 288], 'decoupling': [116, 289], 'synthesis': [119, 292], 'protein': [122, 136, 295, 309], 'gene': [123, 296], 'knockdown.': [129, 302], 'Interestingly,': [130, 303], 'similar': [132, 305], 'reduction': [133, 306], 'levels': [137, 310], 'induction': [141, 314], 'mTOR': [144, 317], 'pathway': [145, 318], 'vitro': [147, 320], 'but': [148, 321], 'not': [149, 322], 'vivo.': [151, 172, 324, 345], 'Overall,': [152, 325], 'this': [153, 326], 'work': [154, 327], 'highlights': [155, 328], 'utility': [157, 330], 'RNAi-based': [160, 333], 'approach': [163, 336], 'for': [164, 337], 'studying': [165, 338], 'regulation': [167, 340], 'mammalian': [169, 342]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2990079676', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}], 'updated_date': '2024-09-11T15:24:31.561356', 'created_date': '2019-12-05'}