Title: The transmetalation step in Pd-catalyzed processes: understanding the role of the classical nucleophile, the ligands and the synthetic potential of a third metal
Abstract:Chapter III deals with the Zn/Pd transmetalation.It provides a fundamental perspective of an undesired group exchange that decreases the efficiency of the Negishi coupling, addressing in great detail ...Chapter III deals with the Zn/Pd transmetalation.It provides a fundamental perspective of an undesired group exchange that decreases the efficiency of the Negishi coupling, addressing in great detail the Pd/Zn interactions governing the group transfer.The computational work described in this chapter was carried out by Dr. Rosana Álvarez at the University of Vigo.Chapter IV contains work carried out throughout the Doctoral studies, in a different topic that is being studied in the group of Valladolid.It consists of a computational and experimental investigation of a phosphine-olefin ligand designed in our group with the aim of enhancing the reactivity of palladium catalysts for challenging syntheses.Part of this work was carried out in a collaboration of the group with Dr. Vladimir V. Grushin of the Institute of Chemical Research of Catalonia.Chapter V involves an experimental investigation of the mechanisms of the N-H oxidative addition of anilines to [(PCP)Ir] complexes.This work was carried out at Rutgers University (New Jersey, USA) under the supervision of Alan S. Goldman as required for the International Doctor Mention.The experimental work of this chapter is not finished and further experimentation is ongoing in Goldman's group.Read More