Title: Signal transduction and protein phosphorylation in bacteria
Abstract:Prior to 1986 it was assumed that protein phosphorylation played a relatively minor role in controlling the response of prokaryotes to environmental stimuli. Although many phosphoproteins had been det...Prior to 1986 it was assumed that protein phosphorylation played a relatively minor role in controlling the response of prokaryotes to environmental stimuli. Although many phosphoproteins had been detected by gel electrophoresis and a number of protein kinases had been purified, the physiological relevance of phosphorylation was not evident (Cozzone, 1984). The discovery of a role for phosphorylation in the response of bacteria to nitrogen status provided the first example of a defined stimulus–response pathway in which protein activity is controlled reversibly by phosphorylation and dephosphorylation (Ninfa & Magasanik, 1986). In the nitrogen regulation system two protein components are involved; one protein is a ‘sensor’ which has protein kinase activity and the other protein is a ‘regulator’ whose activity is responsive to phosphorylation. This pattern of ‘two-component regulation’ is surprisingly well conserved and serves to regulate a range of diverse processes in prokaryotes.Read More
Publication Year: 1993
Publication Date: 1993-03-18
Language: en
Type: book-chapter
Indexed In: ['crossref']
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