Publication Information

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'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2148612803', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'Article29': [0], 'November': [1], '2019Open': [2], 'Access': [3], 'Source': [4, 2091, 3146, 4290, 4298], 'DataTransparent': [5], 'process': [6, 711, 3636], 'Glutathione': [7], 'peroxidase': [8, 778, 1505], '8': [9, 779, 1521, 3079, 3849, 3863, 3938, 4165], 'negatively': [10, 902, 933], 'regulates': [11], 'caspase-4/11': [12, 762, 828, 845, 861, 904, 935, 962, 978, 982, 986, 1013, 1284, 1436, 1681, 1715], 'to': [13, 721, 724, 784, 827, 851, 943, 961, 1094, 1144, 1211, 1263, 1274, 1294, 1307, 1439, 1452, 1577, 1719, 1784, 1826, 1851, 1858, 1875, 1909, 2013, 2340, 2422, 2474, 2476, 2485, 2588, 2613, 2631, 2728, 2858, 3024, 3165, 3176, 3191, 3219, 3266, 3297, 3569, 3656, 3723, 3760, 3812, 4132], 'protect': [14], 'against': [15, 899, 930, 1442, 1660, 3446], 'colitis': [16, 785, 855, 870, 881, 900, 931, 944, 990, 1001, 1329, 1395, 1662, 1740, 1911, 2109, 2124, 2193, 2527, 2607, 2731, 2746, 3167, 3251, 3276, 3333, 3364], 'Jye-Lin': [17, 21, 291, 295, 567], 'Hsu': [18, 22, 107, 109, 292, 296, 381, 383, 568], 'Corresponding': [19, 252, 293, 526], 'Author': [20, 253, 294, 527, 565], '[email': [23, 256, 297, 530, 681, 689], 'protected]': [24, 257, 298, 531, 682, 690], 'orcid.org/0000-0001-6687-4083': [25, 299], 'Graduate': [26, 81, 300, 355], 'Institute': [27, 82, 301, 356, 592], 'of': [28, 56, 61, 83, 111, 150, 156, 178, 184, 194, 234, 238, 275, 279, 302, 330, 335, 357, 385, 424, 430, 452, 458, 468, 508, 512, 549, 553, 593, 610, 615, 625, 641, 647, 657, 665, 669, 697, 707, 747, 795, 806, 813, 820, 835, 840, 860, 869, 885, 954, 969, 974, 981, 1005, 1052, 1084, 1091, 1097, 1106, 1122, 1155, 1184, 1208, 1214, 1224, 1266, 1271, 1340, 1368, 1373, 1381, 1407, 1446, 1465, 1486, 1523, 1548, 1617, 1620, 1678, 1727, 1834, 1839, 1848, 1924, 1985, 2020, 2036, 2043, 2062, 2122, 2134, 2155, 2178, 2187, 2234, 2242, 2247, 2276, 2304, 2356, 2443, 2462, 2493, 2522, 2553, 2593, 2605, 2619, 2622, 2633, 2646, 2659, 2681, 2699, 2786, 2796, 2882, 2909, 2952, 2955, 2976, 2979, 3032, 3119, 3180, 3201, 3238, 3342, 3349, 3369, 3377, 3392, 3444, 3470, 3495, 3520, 3555, 3575, 3697, 3727, 3735, 3806, 3873, 3888, 3895, 3911, 3920, 3943, 3963, 3987, 4008, 4035, 4052, 4063, 4105, 4137, 4143, 4170, 4234], 'Biomedical': [29, 84, 303, 358, 594], 'Sciences,': [30, 85, 304, 359, 595], 'China': [31, 39, 64, 86, 94, 159, 187, 196, 262, 305, 313, 338, 360, 368, 433, 461, 470, 536, 596, 604, 618, 650, 659], 'Medical': [32, 40, 65, 87, 95, 160, 188, 197, 263, 306, 314, 339, 361, 369, 434, 462, 471, 537, 597, 605, 619, 651, 660], 'University,': [33, 41, 88, 96, 116, 198, 264, 307, 315, 362, 370, 390, 472, 538, 598, 606, 630, 661], 'Taichung,': [34, 42, 68, 89, 97, 163, 191, 199, 265, 308, 316, 342, 363, 371, 437, 465, 473, 539, 599, 607, 622, 654, 662], 'Taiwan': [35, 43, 69, 90, 98, 118, 137, 164, 192, 200, 219, 266, 273, 309, 317, 343, 364, 372, 392, 411, 438, 466, 474, 493, 540, 547, 600, 608, 623, 632, 639, 655, 663], 'Drug': [36, 91, 259, 310, 365, 533], 'Development': [37, 92, 260, 311, 366, 534, 602], 'Center,': [38, 93, 133, 215, 261, 269, 312, 367, 407, 489, 535, 543, 603, 635], 'Search': [44, 70, 99, 119, 138, 165, 201, 220, 243, 284, 318, 344, 373, 393, 412, 439, 475, 494, 517, 558], 'for': [45, 71, 100, 120, 139, 166, 202, 221, 244, 285, 319, 345, 374, 394, 413, 440, 476, 495, 518, 559, 743, 754, 916, 1028, 1042, 1248, 1645, 1895, 1906, 2001, 2065, 2096, 2126, 2132, 2146, 2198, 2212, 2226, 2269, 2538, 3010, 3012, 3045, 3070, 3078, 3085, 3107, 3151, 3283, 3308, 3455, 3637, 3834, 3848, 3856, 3862, 3869, 3925, 3937, 4096, 4295, 4300], 'more': [46, 72, 101, 121, 140, 167, 203, 222, 245, 286, 320, 346, 375, 395, 414, 441, 477, 496, 519, 560, 782, 941, 2424, 4127], 'papers': [47, 73, 102, 122, 141, 168, 204, 223, 246, 287, 321, 347, 376, 396, 415, 442, 478, 497, 520, 561], 'by': [48, 74, 103, 123, 142, 169, 205, 224, 247, 288, 322, 348, 377, 397, 416, 443, 479, 498, 521, 562, 901, 932, 1048, 1068, 1193, 1402, 1545, 1685, 1713, 1792, 1947, 2152, 2171, 2195, 2260, 2295, 2309, 2322, 2345, 2367, 2400, 2436, 2449, 2512, 2571, 2760, 2913, 2947, 3007, 3019, 3203, 3462, 3584, 3651, 3828, 3877, 3892, 3900, 3915, 3947, 3955, 3976, 3994, 4031, 4057, 4121, 4135], 'this': [49, 75, 104, 124, 143, 170, 206, 225, 248, 289, 323, 349, 378, 398, 417, 444, 480, 499, 522, 563, 1348, 1651, 1675, 1854, 2015, 2097, 2481, 2860, 3152, 3717, 3801, 4296], 'author': [50, 76, 105, 125, 144, 171, 207, 226, 249, 290, 324, 350, 379, 399, 418, 445, 481, 500, 523, 564, 719], 'Jen-Wei': [51, 53, 325, 327, 570], 'Chou': [52, 54, 326, 328], 'Division': [55, 149, 177, 329, 423, 451], 'Gastroenterology': [57, 331, 611], 'and': [58, 152, 154, 180, 182, 332, 426, 428, 454, 456, 587, 612, 643, 645, 700, 718, 736, 757, 786, 789, 793, 837, 842, 856, 887, 909, 945, 948, 952, 971, 1007, 1038, 1059, 1088, 1100, 1114, 1133, 1147, 1161, 1175, 1182, 1190, 1221, 1245, 1256, 1269, 1314, 1354, 1384, 1418, 1472, 1499, 1531, 1538, 1603, 1625, 1663, 1666, 1690, 1723, 1741, 1746, 1821, 1837, 1882, 1887, 1890, 1942, 1950, 1969, 1975, 1982, 2009, 2038, 2069, 2110, 2114, 2130, 2159, 2182, 2189, 2231, 2239, 2244, 2272, 2279, 2319, 2327, 2379, 2398, 2500, 2545, 2555, 2566, 2585, 2673, 2697, 2756, 2768, 2803, 2845, 2870, 2884, 2898, 2945, 2957, 2961, 2968, 2995, 3004, 3021, 3043, 3073, 3112, 3125, 3235, 3241, 3247, 3295, 3374, 3379, 3395, 3431, 3436, 3458, 3501, 3572, 3578, 3624, 3729, 3798, 3809, 3841, 3904, 3932, 3980, 4005, 4011, 4017, 4021, 4043, 4081, 4107, 4111, 4154, 4178, 4211, 4229, 4240, 4265], 'Hepatology,': [59, 333, 613], 'Department': [60, 110, 155, 183, 233, 274, 334, 384, 429, 457, 507, 548, 614, 646], 'Internal': [62, 157, 185, 336, 431, 459, 616, 648], 'Medicine,': [63, 158, 186, 195, 337, 432, 460, 469, 617, 649, 658], 'University': [66, 161, 189, 237, 278, 340, 435, 463, 511, 552, 620, 652, 668], 'Hospital,': [67, 162, 190, 341, 436, 464, 621, 653], 'Tzu-Fan': [77, 79, 351, 353, 572], 'Chen': [78, 80, 352, 354, 1556, 1800], 'Jeh-Ting': [106, 108, 380, 382, 574], 'Information': [112, 386, 566, 626], 'Management,': [113, 387, 627], 'Hsing': [114, 388, 628], 'Wu': [115, 173, 175, 389, 447, 449, 629], 'Taipei,': [117, 136, 218, 272, 391, 410, 492, 546, 631, 638], 'Fang-Yi': [126, 128, 400, 402, 576], 'Su': [127, 129, 401, 403], 'orcid.org/0000-0003-4235-5283': [130, 404], 'Genomics': [131, 213, 267, 405, 487, 541], 'Research': [132, 214, 268, 406, 488, 542, 634], 'Academia': [134, 216, 270, 408, 490, 544, 636], 'Sinica,': [135, 217, 271, 409, 491, 545, 637], 'Joung-Liang': [145, 147, 419, 421, 578], 'Lan': [146, 148, 420, 422], 'Rheumatology': [151, 179, 425, 453, 642], 'Immunology': [153, 181, 427, 455, 644], 'Po-Chang': [172, 174, 446, 448, 580], 'orcid.org/0000-0001-8109-6996': [176, 450], 'College': [193, 467], 'Chun-Mei': [208, 210, 482, 484, 582], 'Hu': [209, 211, 483, 485], 'orcid.org/0000-0002-4248-0896': [212, 486], 'Eva': [227, 230, 501, 504, 584], 'Y-HP': [228, 231, 502, 505, 585], 'Lee': [229, 232, 251, 255, 503, 506, 525, 529, 589], 'Biological': [235, 276, 509, 550, 666], 'Chemistry,': [236, 277, 510, 551, 667], 'California,': [239, 280, 513, 554, 670], 'Irvine,': [240, 281, 514, 555, 671], 'CA,': [241, 282, 515, 556, 672], 'USA': [242, 283, 516, 557, 673], 'Wen-Hwa': [250, 254, 524, 528, 588], 'orcid.org/0000-0002-3117-931X': [258, 532], '*,1,2,': [569], 'Chou3,': [571], 'Chen1,2,': [573], 'Hsu4,': [575], 'Su5,': [577], 'Lan6,': [579], 'Wu6,7,': [581], 'Hu5,': [583], 'Lee8': [586], '*,2,5,8': [590], '1Graduate': [591], '2Drug': [601], '3Division': [609], '4Department': [624], '5Genomics': [633], '6Division': [640], '7College': [656], '8Department': [664], '*Corresponding': [674, 683], 'author.': [675, 684], 'Tel:': [676, 685], '+88': [677, 686], '6422052121': [678], '#7706;': [679], 'E-mail:': [680, 688], '6227898777;': [687], 'EMBO': [691], 'Mol': [692], 'Med': [693], '(2020)12:e9386https://doi.org/10.15252/emmm.201809386': [694], 'PDFDownload': [695], 'PDF': [696], 'article': [698], 'text': [699], 'main': [701], 'figures.': [702], 'Peer': [703], 'ReviewDownload': [704], 'a': [705, 810, 817, 985, 1012, 1024, 1119, 1397, 1492, 1510, 1642, 1705, 1786, 2323, 2454, 2590, 2717, 2741, 2770, 2852, 3490, 3564, 3704, 3739, 3794], 'summary': [706], 'the': [708, 748, 773, 796, 867, 955, 1082, 1089, 1095, 1104, 1166, 1180, 1195, 1206, 1212, 1215, 1218, 1222, 1264, 1341, 1374, 1408, 1447, 1463, 1495, 1520, 1524, 1626, 1637, 1668, 1709, 1725, 1729, 1752, 1776, 1813, 1818, 1828, 1832, 1929, 1983, 2027, 2076, 2117, 2127, 2176, 2183, 2255, 2334, 2346, 2350, 2374, 2380, 2394, 2402, 2444, 2469, 2494, 2498, 2519, 2526, 2575, 2603, 2617, 2626, 2634, 2644, 2679, 2695, 2722, 2729, 2745, 2777, 2783, 2792, 2841, 2875, 2934, 2972, 2977, 3086, 3128, 3166, 3178, 3187, 3280, 3407, 3441, 3451, 3467, 3506, 3556, 3644, 3666, 3762, 3769, 3780, 3889, 4014, 4024, 4047, 4138, 4243, 4258, 4271], 'editorial': [709, 713], 'decision': [710, 714], 'including': [712, 1034, 1118], 'letters,': [715], 'reviewer': [716], 'comments': [717], 'responses': [720], 'feedback.': [722], 'ToolsAdd': [723], 'favoritesDownload': [725], 'CitationsTrack': [726], 'CitationsPermissions': [727], 'ShareFacebookTwitterLinked': [728], 'InMendeleyWechatReddit': [729], 'Figures': [730], '&': [731, 1072, 1227, 1299, 1863, 2596], 'Info': [732], 'Abstract': [733], 'Human': [734, 907, 3098], 'caspase-4': [735, 841, 889, 908, 1009], 'its': [737, 910, 1148, 1356, 1500, 1849], 'mouse': [738, 911, 2365, 2883], 'homolog': [739, 912], 'caspase-11': [740, 913, 1146, 1209, 1345, 1466, 3807, 4003, 4012, 4053], 'are': [741, 781, 914, 940, 1040, 1152, 1162, 1237, 1246, 1290, 1304, 1539, 2073, 2093, 2258, 2391, 2568, 3117, 3148, 3404, 3815, 4044, 4232, 4255, 4292], 'receptors': [742, 1057, 3473, 3546], 'cytoplasmic': [744, 3896], 'lipopolysaccharide.': [745], 'Activation': [746, 3872, 3887, 3962], 'caspase-4/11-dependent': [749], 'NLRP3': [750, 1219, 1473, 2627, 3557, 3608, 3639, 3678, 3822], 'inflammasome': [751, 1085, 1107, 1159, 1350, 1474, 1497, 1711, 1731, 3092, 3558, 3609, 3615, 3640, 3646, 3679, 3690, 3823, 3874, 3885, 3891, 3913, 3945, 3965, 4079], 'is': [752, 763, 1046, 1109, 1352, 1358, 1387, 1400, 1481, 1778, 1790, 1805, 1856, 2320, 2343, 2472, 2515, 2611, 2629, 2865, 2893, 2969, 3663], 'required': [753, 915, 1774], 'innate': [755, 917], 'defense': [756, 1441, 3445], 'endotoxic': [758, 787, 946, 3433, 3813, 4133], 'shock,': [759, 788, 947], 'but': [760, 1303, 2780, 2812, 2834], 'how': [761, 923, 1347], 'modulated': [764, 1353, 3461], 'remains': [765, 1363], 'unclear.': [766], 'Here,': [767], 'we': [768, 1653, 1672, 1867, 2478, 2533, 2748, 2790, 3169, 3464, 3676, 3750, 3767], 'show': [769, 1604, 1632], 'that': [770, 801, 896, 1343, 1377, 1399, 1483, 1565, 1573, 1628, 1655, 1674, 1701, 1769, 1789, 1808, 2468, 2602, 2713, 2805, 2848, 3262, 3526], 'mice': [771, 800, 1289, 1598, 1631, 1737, 1750, 1759, 1782, 1871, 1892, 1926, 1934, 1957, 1963, 1992, 1996, 2022, 2025, 2106, 2191, 2223, 2420, 2430, 2464, 2547, 2562, 2610, 2651, 2675, 2707, 2930, 2997, 3042, 3207, 3217, 3254, 3288, 3317, 3327, 3357, 3522, 3799, 4068, 4092, 4125, 4131, 4144, 4171, 4197], 'lacking': [772, 938], 'oxidative': [774, 926, 1488, 1570], 'stress': [775, 927, 1489, 1571, 1575], 'sensor': [776, 1572], 'glutathione': [777, 1504], '(GPx8)': [780], 'susceptible': [783, 942, 1306, 4128], 'exhibit': [790, 949, 1599, 1738, 2107], 'reduced': [791, 950, 1742, 2111, 2704], 'richness': [792, 951, 1745, 2113, 2368, 2376, 2696], 'diversity': [794, 953, 1747, 2115, 2698], 'gut': [797, 956, 1669, 1743, 2118, 2635, 2647, 2700, 2723, 2842, 3189], 'microbiome.': [798, 957, 1670, 2724], 'C57BL/6': [799, 3206, 3316], 'underwent': [802], 'adoptive': [803, 3172, 3298], 'cell': [804, 2438, 2801, 3173, 3299, 3736, 4025], 'transfer': [805, 3174, 3300], 'GPx8-deficient': [807, 872, 993, 1629, 1748, 2725, 3162, 3181, 3263, 3272, 3701], 'macrophages': [808, 1624, 1658, 2270, 2458, 2573, 2623, 2726, 2736, 2869, 2897, 3099, 3163, 3182, 3202, 3211, 3228, 3240, 3264, 3273, 3309, 3319, 3702, 3720, 3778], 'displayed': [809, 3229, 3703, 3779], 'similar': [811], 'phenotype': [812, 2732, 3782], 'enhanced': [814, 3883, 4002, 4077], 'colitis,': [815], 'indicating': [816], 'critical': [818, 1511, 2516], 'role': [819, 1493, 1512, 1644, 2719, 2743, 2853], 'GPx8': [821, 824, 836, 848, 897, 939, 958, 970, 1532, 1621, 1646, 1656, 1679, 1689, 1702, 1770, 1881, 2044, 2057, 2066, 2739, 2797, 2806, 2826, 2849, 2864, 2892, 2910, 2956, 2960, 2983, 3054, 3424, 3527, 3541, 3662, 3818, 3829, 3881, 3916, 3948, 3959, 4000, 4058, 4075], 'in': [822, 871, 992, 1017, 1081, 1179, 1240, 1259, 1337, 1360, 1421, 1462, 1494, 1513, 1517, 1623, 1647, 1657, 1708, 1717, 1732, 1817, 1902, 1955, 1961, 1990, 2046, 2067, 2116, 2281, 2363, 2457, 2459, 2517, 2525, 2560, 2574, 2608, 2705, 2720, 2744, 2753, 2765, 2776, 2782, 2798, 2810, 2814, 2830, 2836, 2840, 2854, 2868, 2896, 2900, 3094, 3397, 3426, 3665, 3673, 3695, 3707, 3738, 3800, 3950, 3966, 3990, 4013, 4023, 4083, 4115, 4196], 'macrophages.': [823, 2620, 2855, 3097, 3258], 'binds': [825, 959], 'covalently': [826, 960], 'via': [829, 963, 3567], 'disulfide': [830, 964, 1686], 'bonding': [831, 965, 1687], 'between': [832, 966, 1414, 1688, 1880, 2542, 2671, 3796], 'cysteine': [833, 838, 967, 972], '79': [834, 968], '118': [839, 973], 'thus': [843, 976, 1822], 'restrains': [844, 977], 'activation,': [846, 1346, 3641], 'while': [847], 'deficiency': [849, 2297, 2715, 2984, 3425, 3819, 3882, 3917, 3949, 4001, 4076], 'leads': [850, 1210], 'caspase-4/11-induced': [852], 'inflammation': [853, 2427], 'during': [854, 1928], 'septic': [857, 1296], 'shock.': [858, 1287], 'Inhibition': [859, 980], 'activation': [862, 983, 1090, 1183, 1207, 1223, 1285, 1475, 2618, 3093, 3457, 3554, 3610, 3680, 3808, 3824, 3914, 4080, 4136], 'with': [863, 879, 984, 999, 1019, 1111, 1410, 1872, 1959, 1994, 1998, 2140, 2192, 2209, 2267, 2616, 2678, 2687, 2738, 2874, 2888, 2933, 2943, 3000, 3051, 3066, 3076, 3082, 3102, 3114, 3226, 3249, 3253, 3256, 3290, 3306, 3388, 3485, 3587, 3614, 3654, 3688, 3710, 3716, 3742, 3753, 3783, 3817, 3837, 3844, 3852, 3928, 3935, 3968, 4040, 4094, 4146, 4159, 4173, 4183, 4206, 4216], 'small': [864], 'molecules': [865], 'reduces': [866, 989], 'severity': [868, 991, 3232], 'mice.': [873, 994, 2033, 2040, 2053, 3350, 3480], 'Notably,': [874], 'colonic': [875, 2426, 2460, 2539, 2787], 'tissues': [876, 996, 2759], 'from': [877, 997, 1541, 2049, 2491, 2497, 2649, 2929, 2965, 2993, 3038, 3213, 3287, 3321, 3354, 3478, 3518, 4066, 4087], 'patients': [878, 998], 'ulcerative': [880, 1000, 1394], 'display': [882, 1002], 'low': [883, 1003, 2339], 'levels': [884, 1004, 1619, 1722, 1984, 2061, 2355, 2552, 3696, 4195], 'Gpx8': [886, 1006, 2296, 2714, 2750], 'high': [888, 1008, 1535, 1618, 2341], 'expression.': [890, 1010], 'In': [891, 1142, 1650, 1846, 2332, 2388, 2550, 2693, 3508, 4227, 4252, 4262], 'conclusion,': [892], 'these': [893], 'results': [894, 1699, 2600, 2711, 3260, 3771], 'suggest': [895, 3261], 'protects': [898, 929], 'regulating': [903, 934], 'activity.': [905, 936], 'Synopsis': [906], 'immune': [918, 1648, 1794, 1835, 1883, 2252, 2800], 'responses.': [919, 1884], 'This': [920], 'study': [921, 1859, 1930], 'highlights': [922, 1724], 'GPx8,': [924, 3463], 'an': [925, 1020, 1060, 1403, 1569, 3171, 3733, 3756], 'sensor,': [928], 'Mice': [937, 2137, 2168, 3224], 'caspase-4,': [975, 1036, 1691], 'activation.': [979, 3886, 4006], 'inhibitor,': [987], 'VX-765,': [988], 'Colonic': [995, 2158, 2927], 'Using': [1011], 'inhibitor': [1014], 'alone': [1015], 'or': [1016, 2051, 2148, 2686, 2817, 2903, 2938, 2959, 3040, 3068, 3081, 3105, 3215, 3292, 3325, 3530, 3598, 3668, 3865, 3972, 4090], 'combination': [1018], 'antioxidant': [1021], 'may': [1022, 1450, 1771, 2482, 2850], 'be': [1023, 1066, 1773, 2483, 2589, 2614, 3582, 3612, 3649, 3953], 'promising': [1025], 'therapeutic': [1026], 'option': [1027], 'IBD': [1029, 1369, 1392, 1415, 1860], 'patients.': [1030], 'Introduction': [1031], 'Inflammatory': [1032], 'caspases,': [1033], 'caspase-1,': [1035, 1092, 1145, 4019, 4109], 'caspase-5,': [1037], 'caspase-11,': [1039, 4020, 4110], 'crucial': [1041], 'innate-immune': [1043, 1405, 3438], 'defense.': [1044, 1649], 'Caspase-1': [1045], 'activated': [1047, 1067, 1153, 2572, 3239], 'canonical': [1049, 1158, 1216, 3607, 3667, 3689], 'inflammasomes,': [1050, 1220], 'consisting': [1051], 'intracellular': [1053, 1272, 3743, 3788], 'nucleotide-binding': [1054], 'oligomerization': [1055], 'domain-like': [1056], '(NLRs)': [1058], 'adaptor': [1061], 'protein,': [1062], 'ASC.': [1063], 'NLRs': [1064], 'can': [1065, 1170, 3581, 3611, 3648, 3952], 'cognate': [1069], 'ligands': [1070], '(Lamkanfi': [1071, 1226, 1298], 'Dixit': [1073, 1228, 1300], 'Vishva,': [1074, 1229, 1301], '2014;': [1075, 1230], 'Swanson': [1076], 'et': [1077, 1126, 1130, 1139, 1187, 1202, 1232, 1278, 1311, 1319, 1331, 1428, 1432, 1469, 1477, 1553, 1557, 1593, 1608, 1612, 1797, 1801, 1843, 2530, 2578, 2582, 2638, 3627, 3631], 'al,': [1078, 1127, 1131, 1140, 1188, 1203, 1233, 1279, 1312, 1320, 1332, 1429, 1433, 1470, 1478, 1554, 1558, 1594, 1609, 1613, 1798, 1802, 1844, 2531, 2579, 2583, 2639, 3628, 3632], '2017),': [1079], 'resulting': [1080, 1178], 'assembly': [1083, 1213], 'protein': [1086, 1584, 2793, 3573, 4036], 'complexes': [1087], 'leading': [1093, 1262], 'release': [1096, 3724, 3906, 3982], 'inflammatory': [1098, 1134, 1371, 2437, 2470, 2502], 'cytokines': [1099, 1841, 3016], 'consequent': [1101], 'inflammation.': [1102], 'Thus,': [1103, 1235, 1866], 'dysregulation': [1105, 1445], 'activity': [1108, 1551, 1682, 1716, 3469], 'associated': [1110, 1501, 2615, 3816], 'both': [1112, 2754], 'pathogen-related': [1113], 'proinflammatory,': [1115], 'non-microbial': [1116], 'diseases,': [1117], 'broad': [1120], 'spectrum': [1121, 1367], 'autoinflammatory': [1123], 'diseases': [1124], '(Vandanmagsar': [1125], '2011;': [1128], 'Wen': [1129], '2011)': [1132], 'bowel': [1135], 'disease': [1136, 1362, 1398, 3184, 3231], '(IBD)': [1137], '(Caruso': [1138], '2014).': [1141, 1333, 1845], 'contrast': [1143], 'human': [1149, 1361, 1852, 2757, 2885, 3096, 3776, 3958], 'counterpart,': [1150], 'caspase-4/5,': [1151], 'independently': [1154, 3919], 'all': [1156, 1932, 3471, 3509], 'known': [1157, 2587, 3642], 'stimuli': [1160, 3691, 3790], 'therefore': [1163, 1291, 2642], 'identified': [1164], 'as': [1165, 1322, 1324, 1568, 1582, 1704, 1756, 1964, 1966, 2031, 2075, 2393, 2434, 2625, 2971, 3027, 3127, 3406, 3505, 3550, 3591, 3618, 3643, 3671, 3755, 4242, 4257], 'non-canonical': [1167, 1349, 1448, 1496, 1710, 1730, 3091, 3645, 3669, 3884, 3890, 3912, 3944, 3964, 4078, 4139], 'pathway.': [1168], 'Caspase-11/4/5': [1169], 'directly': [1171], 'recognize': [1172], 'bacteria': [1173, 1273, 1825, 2361], 'LPS': [1174, 3067, 3077, 3599, 3655, 3712, 3744, 3752, 3789, 3840, 3845, 3897, 3936, 4072, 4148, 4160, 4184, 4217], 'undergo': [1176], 'oligomerization,': [1177], 'cleavage': [1181, 4004], 'itself': [1185], '(Shi': [1186], '2014)': [1189, 1471], 'initiating': [1191], 'pyroptosis': [1192, 1196, 1258, 3430, 4082], 'cleaving': [1194], 'effector': [1197], 'gasdermin': [1198, 4112], 'D': [1199, 4113], '(GSDMD)': [1200, 4114], '(Kayagaki': [1201], '2015).': [1204, 1234, 1479], 'Consequently,': [1205], 'inflammasome,': [1217], 'caspase-1': [1225, 4010], 'Yang': [1231], 'caspase-11/4/5': [1236], 'key': [1238, 2742], 'players': [1239], 'sensing': [1241], 'cytosolic': [1242], 'lipopolysaccharide': [1243], '(LPS)': [1244], 'responsible': [1247, 3454], 'LPS-induced': [1249, 1295, 1664], 'lethality.': [1250], 'Caspase-11': [1251, 4060], 'senses': [1252], 'various': [1253, 2047], 'bacterial': [1254, 1422, 1443, 2310, 2661, 2701], 'infections': [1255], 'induces': [1257], 'infected': [1260], 'cells,': [1261], 'lysis': [1265], 'bacteria-containing': [1267], 'vacuoles': [1268], 'exposure': [1270, 3221], 'neutrophil-mediated': [1275], 'killing': [1276], '(Miao': [1277], '2010).': [1280], 'During': [1281], 'endotoxemia,': [1282], 'excessive': [1283], 'causes': [1286], 'Caspase-11−/−': [1288], 'highly': [1292], 'resistant': [1293], 'shock': [1297, 3434, 3814, 4134], '2014),': [1302], 'particularly': [1305], 'Salmonella': [1308], 'typhimurium': [1309], '(Broz': [1310, 3626], '2012)': [1313], 'Burkholderia': [1315], 'thailandensis': [1316], 'infection': [1317, 1423], '(Hagar': [1318], '2013),': [1321], 'well': [1323, 1806], 'dextran': [1325], 'sulfate': [1326], 'sodium': [1327], '(DSS)-induced': [1328], '(Demon': [1330], 'Despite': [1334], 'new': [1335], 'insights': [1336], 'our': [1338], 'understanding': [1339], 'events': [1342], 'trigger': [1344], 'pathway': [1351, 1449, 1498, 1712, 3453], 'whether': [1355, 2480, 2735, 3161, 3540, 3661], 'regulation': [1357, 1464, 1795], 'important': [1359], 'largely': [1364], 'unknown.': [1365], 'The': [1366, 1503, 2054, 2120, 2250, 2915, 2920, 3340, 3346, 3493, 3553], 'includes': [1370], 'disorders': [1372], 'gastrointestinal': [1375], 'tract': [1376], 'already': [1378], 'affect': [1379], 'millions': [1380], 'people': [1382], 'worldwide,': [1383], 'their': [1385, 1546, 1903], 'incidence': [1386], 'steadily': [1388], 'rising': [1389], '(Hanauer,': [1390], '2006).': [1391], 'includes,': [1393], '(UC),': [1396], 'characterized': [1401, 1791], 'aberrant': [1404], 'response': [1406, 1718, 2471], 'intestine': [1409, 1820], 'multifactorial': [1411], 'etiology.': [1412], 'Associations': [1413], 'susceptibility': [1416, 2604, 3811], 'loci': [1417], 'genes': [1419, 1484], 'involved': [1420, 3664], 'have': [1424, 1563, 1785, 2026, 2423, 2851], 'been': [1425, 1460], 'highlighted': [1426], '(Jostins': [1427], '2012;': [1430, 3629], 'Cleynen': [1431], '2016).': [1434, 1559, 1803], 'Since': [1435], 'contributes': [1437], 'critically': [1438], 'host': [1440], 'pathogens,': [1444], 'lead': [1451], 'colitis.': [1453], 'Importantly,': [1454], 'reactive': [1455], 'oxygen': [1456], 'species': [1457, 2362, 2702], '(ROS)': [1458], 'has': [1459, 2716, 2985, 3528], 'implicated': [1461], 'expression': [1467, 1622, 2045, 2064, 2541, 2751, 2794, 2908, 3574, 4037, 4051, 4062], '(Lupfer': [1468], '(Abais': [1476], 'It': [1480, 1804], 'likely': [1482, 2612], 'capable': [1485], 'modulating': [1487, 1714], 'signals': [1490, 1576], 'play': [1491, 2740], 'diseases.': [1502], '(GPx)': [1506], 'gene': [1507], 'family': [1508], 'plays': [1509], 'controlling': [1514], 'ROS': [1515, 1602, 1721], 'balance': [1516], 'organisms.': [1518], 'Among': [1519], 'members': [1522, 1544], 'mammalian': [1525], 'GPx': [1526, 1543, 1549], 'family,': [1527], 'GPx7': [1528], '(i.e.,': [1529], 'NPGPx)': [1530], 'share': [1533], 'very': [1534], 'structural': [1536], 'similarity': [1537, 3795], 'distinguished': [1540], 'other': [1542, 3083, 3437, 3543], 'lack': [1547], 'enzymatic': [1550], '(Utomo': [1552], '2004;': [1555], 'Our': [1560], 'previous': [1561], 'studies': [1562, 2131], 'shown': [1564, 2764], 'NPGPx': [1566], 'acts': [1567, 1703], 'transmits': [1574], 'activate': [1578, 3657], 'downstream': [1579], 'effectors,': [1580], 'such': [1581, 2624, 3268, 3549, 3590, 3617], 'glucose-regulated': [1583], '(GRP)': [1585], '78,': [1586], 'which': [1587, 1692, 3580], 'subsequently': [1588], 'increases': [1589], 'H2O2': [1590, 1696], 'resistance': [1591], '(Wei': [1592, 1607, 1796], '2012a).': [1595], 'NPGPx-deficient': [1596], '(NPGPx−/−)': [1597], 'systemically': [1600], 'increased': [1601, 1939, 3242, 3784, 3810], 'diverse': [1605], 'phenotypes': [1606, 1635], '2012a;': [1610, 1799], 'Chang': [1611], '2013).': [1614, 3633], 'Conversely,': [1615], 'observations': [1616], 'fact': [1627], '(GPx8−/−)': [1630, 1749], 'no': [1633, 2535, 2986, 3515, 3531, 3693, 4276], 'apparent': [1634], 'under': [1636, 1761, 1779, 2298, 2652, 3186, 3331, 3363, 3681, 3787], 'standard': [1638, 1762, 2299, 2653], 'housing': [1639, 2300, 2654], 'condition': [1640], 'indicate': [1641, 2353, 2601], 'possible': [1643], 'study,': [1652], 'found': [1654, 2804, 3722], 'protected': [1659], 'DSS-induced': [1661, 2123, 2606, 2730, 3250, 3275, 3332], 'sepsis': [1665], 'shaped': [1667, 2294], 'Mechanistically,': [1671], 'uncovered': [1673], 'inhibitory': [1676], 'effect': [1677, 2987, 3179, 3532], 'on': [1680, 2004, 2164, 2217, 2505, 2988, 3057, 3183, 3360, 3533, 4101], 'was': [1683, 1980, 2293, 2307, 2774, 2807, 2827, 2911, 2931, 2963, 3304, 3503, 3825, 3875, 3898, 3974, 3992, 4054, 4069], 'mediated': [1684], 'occurred': [1693, 3918], 'rapidly': [1694], 'upon': [1695], 'treatment.': [1697, 1734], 'These': [1698, 2599, 2710, 3259, 3481], 'indicated': [1700, 1946, 2259, 2360, 2435, 3087, 4045], 'negative': [1706], 'regulator': [1707], 'cellular': [1720], 'importance': [1726], 'targeting': [1728], 'UC': [1733], 'Results': [1735], 'GPx8−/−': [1736, 1870, 1891, 1933, 1956, 1991, 2021, 2024, 2039, 2052, 2070, 2105, 2190, 2419, 2463, 2546, 2561, 2609, 2650, 2674, 2996, 3041, 3214, 3227, 3326, 3479, 3512, 3719, 4067, 4091, 4124], 'exacerbated': [1739, 2108], 'microbiome': [1744, 2112, 2292, 2636], 'had': [1751], 'same': [1753, 2028, 3188, 3770, 3781], 'life': [1754, 2029], 'spans': [1755, 2030], 'wild-type': [1757], '(WT)': [1758], 'housed': [1760], 'pathogen-free': [1763], 'living': [1764], 'conditions': [1765, 3683], '(Fig': [1766, 1912, 1918, 1936, 1973, 2007, 2440, 2465, 2548, 2563, 2684, 2691, 2708, 2820, 2843, 3195, 3222, 3233, 3245, 3523, 3684, 3713, 3746, 3772, 3791], 'EV1),': [1767], 'suggesting': [1768, 2847, 3525, 3793], 'only': [1772], 'when': [1775, 3749], 'animal': [1777], 'stress.': [1780], 'NPGPx−/−': [1781], 'appear': [1783], 'phenotypic': [1787], 'profile': [1788], 'dysfunctional': [1793], 'documented': [1807], 'oral': [1809, 1873], 'DSS': [1810, 1874, 1901, 2000, 2145, 2197, 2211, 2432, 3220, 4095], 'administration': [1811], 'damages': [1812], 'epithelial': [1814, 2513, 2784], 'monolayer': [1815], 'lining': [1816], 'large': [1819], 'allows': [1823], 'intestinal': [1824], 'enter': [1827], 'underlying': [1829], 'tissue,': [1830], 'provoking': [1831], 'infiltration': [1833, 2439], 'cells': [1836, 2253, 2514, 2785, 2819, 2832, 2839, 2954, 3439, 3586], 'production': [1838, 2504, 2511, 3244, 3460, 3709, 4194], 'proinflammatory': [1840], '(Chassaing': [1842], 'view': [1847], 'similarities': [1850], 'UC,': [1853], 'model': [1855, 2125, 2528], 'used': [1857, 2225], 'pathogenesis': [1861], '(Perse': [1862], 'Cerar,': [1864], '2012).': [1865], 'initially': [1868], 'challenged': [1869], 'investigate': [1876], 'any': [1877], 'potential': [1878, 2718, 3193, 3763], 'relationship': [1879], 'Age-,': [1885], 'sex-,': [1886], 'weight-matched': [1888], 'WT': [1889, 1925, 1962, 1995, 2032, 2037, 2050, 2068, 2188, 2429, 2544, 2672, 2994, 3039, 3216, 3322, 3521, 4089, 4130], 'were': [1893, 1916, 1953, 1988, 2138, 2162, 2169, 2215, 2224, 2265, 2557, 2703, 2998, 3017, 3036, 3049, 3064, 3100, 3330, 3358, 3483, 3721, 3832, 3923, 4029, 4038, 4099, 4118, 4126, 4199, 4268], 'co-housed': [1894], '3': [1896, 3108, 3857, 3870], 'weeks,': [1897], 'then': [1898, 3005, 3074, 3110, 3538, 3842, 3933], 'administered': [1899], '4%': [1900, 1999, 2144, 2196, 2210], 'drinking': [1904, 2141], 'water': [1905, 2142], '6': [1907, 2149, 2199, 3835, 3926, 4156, 4180, 4213], 'days': [1908, 2003, 2154, 2200, 2214, 3109, 4098], 'induce': [1910], '1A);': [1913], 'mortality': [1914], 'rates': [1915], 'recorded': [1917], '1B–D).': [1919], 'Whereas': [1920], 'fewer': [1921], 'than': [1922, 2428, 4129], '50%': [1923], 'died': [1927, 1935], 'period,': [1931], '1B).': [1937], 'Moreover,': [1938, 2822], 'weight': [1940, 2180], 'loss': [1941], 'higher': [1943, 2354, 3236], 'clinical': [1944, 2184, 3347], 'scores': [1945, 2185, 3348], 'stool': [1948], 'consistency': [1949], 'occult': [1951], 'bleeding': [1952], 'observed': [1954, 2534, 2775], 'compared': [1958, 1993, 3252], 'values': [1960], 'early': [1965], 'day': [1967, 1970, 2005, 2165, 2218, 2506, 3058, 3061, 3361, 4102], '5': [1968, 2002, 2147, 2213, 2316, 4088, 4097], '2,': [1971], 'respectively': [1972], '1C': [1974], 'D).': [1976], 'Mean': [1977], 'colon': [1978, 2135, 2235, 2248, 2282, 2495, 2576, 2758, 3370, 3382, 3398], 'length': [1979], 'shorter': [1981], 'tissue': [1986, 2283, 2461, 2928, 3399, 4116], 'damage': [1987], 'greater': [1989, 3230], 'treated': [1997, 2208, 3289, 3484, 3687, 4093], '14': [2006], '1E': [2008], 'F).': [2010], 'Click': [2011, 2856], 'here': [2012, 2857], 'expand': [2014, 2859], 'figure.': [2016, 2098, 2861, 3153, 4297], 'Figure': [2017, 2103, 2862, 3270, 3803], 'EV1.': [2018], 'Characterization': [2019], 'A.': [2023, 2119, 2879, 3277, 3820], 'B.': [2034, 2891, 3285, 3880], 'Genotyping': [2035], 'C.': [2041, 2926, 3909], 'Immunoblotting': [2042], 'organs': [2048], 'arrowhead': [2055, 2917, 2922], 'indicates': [2056], 'protein.': [2058], 'D.': [2059, 2950], 'Relative': [2060], 'mRNA': [2063, 3989], 'BMDMs.': [2071], 'Data': [2072, 2386, 3116, 3401, 3403, 4225, 4299], 'presented': [2074, 2321, 2392, 2970, 3126, 3405, 4241, 4256], 'mean': [2077, 2395, 2973, 3129, 3408, 4244, 4259], '±': [2078, 2396, 2974, 3130, 3409, 4245, 4260], 'SD,': [2079, 3131, 4246], 'n': [2080, 3132, 4247], '=': [2081, 2202, 2286, 2315, 3133, 3335, 4164, 4188, 4221, 4248], '3,': [2082], 'technical': [2083, 3135, 4250], 'repeats.': [2084, 3136, 4251], '***P': [2085, 2412, 3140, 3414, 4287], '<': [2086, 2407, 2410, 2413, 3138, 3141, 3412, 3415, 4282, 4285, 4288], '0.001': [2087, 3142, 3416], "(Student's": [2088, 3143, 3417], 'two-tailed': [2089, 2404, 3144, 4273], 't-test).': [2090, 3145, 3419], 'data': [2092, 2390, 3147, 4231, 4254, 4267, 4291], 'available': [2094, 3149, 4293], 'online': [2095, 3150, 4294], 'Download': [2099, 2101, 2415, 2417, 3154, 3156, 3420, 3422], 'figure': [2100, 2416, 3155, 3421], 'PowerPoint': [2102, 2418, 3157, 3423], '1.': [2104], 'design': [2121], 'survival': [2128, 2173], 'experiment': [2129, 3175], 'collection': [2133], 'samples.': [2136], 'supplied': [2139], 'containing': [2143], 'days,': [2150], 'followed': [2151], '8–9': [2153, 4222], 'normal': [2156], 'water.': [2157], 'blood': [2160], 'samples': [2161, 3353, 4086], 'collected': [2163, 2216, 3359, 4100], '14.': [2166, 2219, 2507], 'B–D.': [2167], 'analyzed': [2170, 2791, 2946, 4120, 4269], 'Kaplan–Meier': [2172], 'plot': [2174], '(B),': [2175], 'percentage': [2177, 2978, 3341], 'body': [2179, 3343], '(C),': [2181], '(D)': [2186, 3345, 3961], 'induced': [2194, 3677, 3946], '(n': [2201, 2285, 2314, 3334, 4163, 4187, 4220], '10': [2203, 2287], 'per': [2204, 2288, 2317, 3337, 4166, 4190, 4223], 'group).': [2205, 2289, 3338, 4167, 4191, 4224], 'E–H.': [2206], 'Colons': [2207, 3286], 'For': [2220], '(E–G),': [2221], '5–6': [2222, 3071], 'each': [2227, 2364, 3008], 'experiment.': [2228], '(E)': [2229, 3366, 3985], 'Images': [2230, 2238, 3373], 'statistical': [2232], 'analysis': [2233, 2330, 2658, 2690, 3368], 'length.': [2236, 3371], '(F)': [2237, 3372], 'semiquantitative': [2240, 3375], 'scoring': [2241, 3025, 3376], 'hematoxylin': [2243, 3378], 'eosin': [2245, 3380], 'staining': [2246, 2452, 3381], 'sections.': [2249, 3383], 'infiltrated': [2251], 'at': [2254, 3120, 4235], 'transmural': [2256], 'extensions': [2257], 'arrowhead.': [2261], '(G)': [2262, 3384], 'Colon': [2263, 3352, 3385, 4085], 'sections': [2264, 2881, 3386], 'stained': [2266, 2887, 2932, 3305, 3387], 'markers': [2268, 3307], '(F4/80)': [2271], 'anti-GPx8.': [2273], '(H)': [2274, 3390], 'Production': [2275, 3391], 'IL-1β,': [2277, 3393], 'IL-6,': [2278, 3394], 'IL-18': [2280, 2540, 3396], 'lysates': [2284, 4026, 4117], 'I–K.': [2290, 4123], 'Gut': [2291], 'conditions.': [2301, 2655], 'Bray–Curtis': [2302, 2335, 2682], 'dissimilarity': [2303, 2342, 2683], 'fecal': [2305, 2668], 'microbiota': [2306, 2648, 2669, 3190], 'measured': [2308, 3504, 4070, 4200], '16S': [2311, 2662], 'RNA': [2312, 2663, 3571, 4050, 4061], 'sequencing': [2313, 2664], 'group)': [2318], 'heat': [2324], 'map': [2325], '(I),': [2326, 2333], 'principal': [2328, 2688], 'coordinates': [2329, 2689], '(J).': [2331], 'index': [2336], '(0–0.3)': [2337], 'showing': [2338, 3279], 'represented': [2344], 'red': [2347], 'color': [2348], 'gradient;': [2349], 'deeper': [2351], 'shades': [2352], 'dissimilarity.': [2357], '(K)': [2358, 4192], 'α-Diversity': [2359], 'depicted': [2366], '(total': [2369], 'operational': [2370], 'taxonomic': [2371, 2660], 'units,': [2372], 'OTUs),': [2373], 'Chao1': [2375], 'estimator': [2377, 2383], '(Chao1),': [2378], 'abundance-based': [2381], 'coverage': [2382], '(ACE)': [2384], 'metrics.': [2385], 'information:': [2387, 3402, 4226], '(C–K),': [2389], 'SEM': [2397], 'calculated': [2399, 2964], 'using': [2401, 2823, 3475, 3489, 4270], "Student's": [2403, 4272], 't-test.': [2405, 4274], '*P': [2406, 3411, 4281], '0.05;': [2408, 3413, 4280, 4283], '**P': [2409, 3137, 4284], '0.01;': [2411, 3139, 4286], '0.001.': [2414, 4289], 'appeared': [2421], 'severe': [2425], 'after': [2431, 3301, 4071, 4203], 'administration,': [2433], '1F).': [2441], 'Analysis': [2442], 'macrophage': [2445, 3302, 3314, 3427, 3456], 'population': [2446], '(F4/80+': [2447], 'cells)': [2448], 'immunohistochemistry': [2450], '(IHC)': [2451], 'revealed': [2453, 2665], 'significant': [2455, 2536, 3705, 3725], 'increase': [2456, 3570, 3706], '1G).': [2466], 'Given': [2467], 'thought': [2473], 'contribute': [2475, 2727, 3164, 3265], 'mortality,': [2477], 'investigated': [2479], 'attributed': [2484], 'cytokine': [2486, 2503, 3243, 3459], 'production.': [2487], 'We': [2488, 2641, 3537], 'prepared': [2489], 'homogenates': [2490], 'one-third': [2492], 'extending': [2496], 'appendix': [2499], 'determined': [2501, 4030], 'Although': [2508], 'interleukin': [2509], '(IL)-18': [2510], 'driving': [2518], 'pathologic': [2520], 'breakdown': [2521], 'barrier': [2523], 'integrity': [2524], '(Dupaul-Chicoine': [2529], '2010),': [2532], 'difference': [2537], 'DSS-treated': [2543], '1H).': [2549, 2564], 'contrast,': [2551], 'IL-1β': [2554, 2567, 2586, 3698, 3708, 3728, 3901, 3977, 4193], 'IL-6': [2556, 2565, 2594, 3502], 'significantly': [2558, 2666], 'upregulated': [2559], 'mainly': [2569], 'produced': [2570], '(Akira': [2577], '1993;': [2580], 'Garlanda': [2581], '2013)': [2584], 'potent': [2591], 'inducer': [2592], '(Tosato': [2595], 'Jones,': [2597], '1990).': [2598], 'Overactivation': [2621, 3942], 'hyper-activation': [2628], 'linked': [2630], 'alteration': [2632], '(Yao': [2637], '2017).': [2640], 'examined': [2643, 2749], 'composition': [2645], 'A': [2656, 3030, 3603], 'beta-diversity': [2657], 'different': [2667, 2799, 3893], 'compositions': [2670], 'plotted': [2676], 'either': [2677], 'method': [2680], '1I)': [2685], '1J).': [2692], 'addition,': [2694], 'Gpx8−/−': [2706], '1K).': [2709], 'imply': [2712], 'shaping': [2721], 'To': [2733, 3158, 3449, 3659], 'test': [2734], 'deficient': [2737], 'phenotype,': [2747, 3168], 'profiles': [2752], 'murine': [2755], 'IHC': [2761], 'analysis.': [2762], 'As': [2763], 'Figs': [2766], '1G': [2767], 'EV2A,': [2769], 'strong': [2771], 'positive': [2772], 'signal': [2773, 3566, 3605, 3765], 'lamina': [2778], 'propria,': [2779], 'not': [2781, 2813, 2835, 2872, 2899, 3826, 4055], 'tissues.': [2788], 'Next,': [2789], 'pattern': [2795, 3544], 'populations': [2802], 'predominantly': [2808, 2828, 2867, 2895], 'expressed': [2809, 2829, 2866, 2894], 'macrophages,': [2811], 'T,': [2815, 2901], 'B,': [2816, 2902], 'dendritic': [2818, 2904, 2939], 'EV2B).': [2821], 'immunofluorescence': [2824], 'staining,': [2825], 'F4/80+': [2831], '(macrophages)': [2833], 'CD103+': [2837], '(dendritic)': [2838], 'EV2C': [2844], 'D),': [2846], 'EV2.': [2863], 'does': [2871], 'interfere': [2873], 'TLR': [2876, 2989, 3487, 3534, 3588], 'signaling': [2877, 2990, 3452, 3468, 3535], 'pathways': [2878, 3559, 3670], 'Tissue': [2880], 'colons': [2886], 'anti-GPx8': [2889, 2944], 'Ab.': [2890], 'cells.': [2905, 2981], 'Cell-type': [2906], 'specific': [2907], 'elucidated': [2912], 'immunoblotting.': [2914, 4032], 'black': [2916], 'denotes': [2918, 2923], 'GPx8.': [2919], 'white': [2921], 'non-specific': [2924], 'bands.': [2925], 'pan-macrophage': [2935], 'marker,': [2936, 2940], 'F4/80,': [2937], 'CD103,': [2941], 'combined': [2942], 'confocal': [2948], 'microscopy.': [2949], 'Quantification': [2951], 'double-positive': [2953, 2980], 'CD103': [2958], 'F4/80': [2962], '7': [2966, 3046, 3362], 'fields': [2967], 'SD': [2975], 'E.': [2982, 3941], 'pathways.': [2991, 3536], 'BMDMs': [2992, 3035, 3063, 3355, 3476, 3482, 3513, 3686, 3831, 3922, 3951, 3967, 3991, 4064], 'primed': [2999, 3065, 3111, 3833, 3924, 4145, 4172, 4205], 'IFNγ': [3001], '(250': [3002], 'U/ml)': [3003], 'triggered': [3006], 'ligand': [3009], 'TLRs': [3011, 3510, 3568], '16': [3013], 'h.': [3014, 3871, 3939], 'Secreted': [3015], 'quantified': [3018], 'ELISA': [3020], 'proportionally': [3022], 'simplified': [3023], 'scales': [3026], 'indicated.': [3028], 'F.': [3029, 3999], 'flowchart': [3031], 'experimental': [3033, 3281], 'procedures.': [3034], 'isolated': [3037, 3477, 4065], 'differentiated': [3044], 'days.': [3047], 'Cells': [3048], 'transduced': [3050], 'lentiviruses': [3052], 'expressing': [3053, 3957], 'if': [3055], 'needed': [3056], '3.': [3059, 3804], 'On': [3060], '7,': [3062], 'poly(I:C)': [3069, 3754, 3931, 4174, 4207], 'h': [3072, 3080, 3836, 3927, 4157, 4181, 4202, 4214], 'transfected': [3075, 3101, 3113, 3711, 3843, 3934], 'activators': [3084], 'times.': [3088], 'G.': [3089, 4049], 'Enhanced': [3090], 'GPx8-depleted': [3095, 3775], 'scrambled': [3103], 'siRNA': [3104], 'siGPx8': [3106], 'LPS.': [3115], 'representative': [3118, 4233], 'least': [3121, 4236], 'three': [3122, 4237], 'independent': [3123, 4238], 'experiments': [3124, 4239], '5,': [3134], 'further': [3159], 'determine': [3160, 3450], 'performed': [3170], 'examine': [3177, 3660], 'progression': [3185], 'avoid': [3192], 'interference': [3194], '2A).': [3196], 'After': [3197, 3312], 'undergoing': [3198, 3313], 'complete': [3199], 'depletion': [3200, 3303], 'liposomal': [3204], 'clodronate,': [3205], 'received': [3208, 3318], 'bone': [3209], 'marrow-derived': [3210], '(BMDMs)': [3212], 'prior': [3218], '2B).': [3223], 'transplanted': [3225, 3255, 3356], '2C–F),': [3234], 'numbers': [3237], '2G': [3246], 'H)': [3248], 'GPx8+/+': [3257], 'generating': [3267], 'phenotypes.': [3269], '2.': [3271], 'enhance': [3274], 'Illustration': [3278], 'protocol': [3282], '(B–H).': [3284], 'clodronate': [3291], 'control': [3293], 'liposomes': [3294], 'subjected': [3296], '(F4/80).': [3310], 'C–H.': [3311], 'depletion,': [3315], 'derived': [3320], '(WT': [3323], 'BMDMs)': [3324, 3329], '(GPx8−/−': [3328], '6–9': [3336], '(C)': [3339], 'weight.': [3344], '(E–H)': [3351], 'model.': [3365], 'Statistical': [3367], 'anti-F4/80.': [3389], 'lysates.': [3400], 'SEM.': [3410, 4261], 'one-tailed': [3418], 'potentiates': [3428], 'caspase-11-dependent': [3429], 'exacerbates': [3432], 'Macrophages': [3435], 'provide': [3440], 'first': [3442, 3465], 'line': [3443], 'microorganism': [3447], 'invasion.': [3448], 'tested': [3466, 3539], 'Toll-like': [3472], '(TLRs)': [3474], 'individual': [3486], 'agonists': [3488], 'Multi-TLR': [3491], 'Array™.': [3492], 'secretion': [3494, 3786], 'tumor': [3496], 'necrosis': [3497], 'factor': [3498], 'alpha': [3499], '(TNF-α)': [3500], 'readout.': [3507], 'examined,': [3511], 'showed': [3514, 3692], 'detectable': [3516], 'differences': [3517], 'those': [3519], 'EV2E),': [3524], 'little': [3529], 'influences': [3542], 'recognition': [3545], 'besides': [3547], 'TLRs,': [3548], 'NRP3': [3551], 'inflammasomes.': [3552], 'requires': [3560], 'two': [3561], 'signals:': [3562], 'first,': [3563], 'priming': [3565, 3682, 3758, 3764], 'NLRP3,': [3576], 'pro-IL-1β': [3577], 'pro-caspase-11,': [3579], 'achieved': [3583, 3613], 'treating': [3585], 'ligands,': [3589], 'polyinosinic:': [3592], 'polycytidylic': [3593], 'acid': [3594], '[poly(I:C)](a': [3595], 'TLR3': [3596], 'ligand),': [3597], '(a': [3600], 'TLR4': [3601], 'ligand).': [3602], 'second': [3604], 'triggering': [3606, 3638], 'inducers': [3616], 'monosodium': [3619], 'urate': [3620], '(MSU)': [3621], 'crystals,': [3622], 'nigercin,': [3623], 'ATP': [3625, 3853], 'Hagar': [3630], 'An': [3634], 'alternative': [3635, 3757], 'pathway,': [3647], 'initiated': [3650], 'transfecting': [3652], 'primed-BMDMs': [3653], 'caspase-11.': [3658], 'described': [3672], 'Fig': [3674], 'EV2F,': [3675], '3A).': [3685, 3714], 'change': [3694], 'production,': [3699], 'whereas': [3700], 'Consistent': [3715], 'finding,': [3718], 'amounts': [3726, 3894], 'lactate': [3730], 'dehydrogenase': [3731], '(LDH),': [3732], 'indicator': [3734], 'death,': [3737], 'dose-dependent': [3740], 'manner': [3741], 'stimulation': [3745], '3B).': [3747], 'Equivalently,': [3748], 'substituted': [3751], 'agent': [3759], 'exclude': [3761], 'bias,': [3766], 'obtained': [3768], '3C).': [3773], 'Interestingly,': [3774], 'monocyte-derived': [3777], 'IL-β': [3785], 'EV2G),': [3792], 'humans': [3797], 'aspect.': [3802], 'Enhancement': [3805], 'Canonical': [3821], 'altered': [3827, 4056], 'deficiency.': [3830, 4059], '0.5': [3838], 'μg/ml': [3839, 3930], '(TF': [3846], 'LPS)': [3847], 'h,': [3850, 3858, 3864], 'stimulated': [3851], '(5': [3854, 3867], 'mM)': [3855], 'MSU': [3859], '(150': [3860], 'μg/ml)': [3861], 'nigericin': [3866], 'μM)': [3868], 'demonstrated': [3876], 'secreted': [3878], 'IL-1β.': [3879], 'verified': [3899, 3975], '(left': [3902, 3978], 'panel)': [3903, 3979], 'LDH': [3905, 3981], '(right': [3907, 3983], 'panel).': [3908, 3984], 'Upregulation': [3910], 'TLRs.': [3921], '1': [3929, 4176, 4209], 'D,': [3940], 'rescued': [3954], 'ectopically': [3956], '(hGPx8).': [3960], 'empty': [3969], 'vector': [3970], '(EV)': [3971], 'hGPx8': [3973, 3988], 'Expression': [3986], 'confirmed': [3993], 'quantitative': [3995], 'reverse': [3996], 'transcriptase': [3997], 'PCR.': [3998], 'Levels': [4007, 4104], 'processed': [4009, 4108], 'supernatants': [4015], '(Sup)': [4016], 'full-length': [4018, 4106], 'GAPDH': [4022], '(Cell': [4027], 'ext)': [4028], 'Fold': [4033], 'changes': [4034], 'normalized': [4039], 'internal': [4041], 'controls': [4042], 'below': [4046], 'blots.': [4048], 'priming.': [4073], 'H.': [4074], 'vivo.': [4084], '7.': [4103], 'individually': [4119], 'immunoblots.': [4122], 'inflammasome.': [4140], '(I)': [4141], 'Survival': [4142, 4169], 'ultra-pure': [4147], '(E.': [4149], 'coli': [4150], 'O55:B5,': [4151], '400': [4152], 'μg/kg)': [4153], 're-challenged': [4155, 4179, 4212], 'later': [4158, 4182, 4215], '(40': [4161], 'mg/kg)': [4162, 4177, 4186, 4210, 4219], '(J)': [4168], '(LMW': [4175, 4208], '(10': [4185], '9': [4189], 'sera': [4198], '2': [4201], 'being': [4204], '(1': [4218], '(A–E': [4228], 'G),': [4230], '4–5,': [4249], '(K),': [4253], '(A–E,': [4263], 'G': [4264], 'K),': [4266], 'NS,': [4275], 'significance.': [4277], 'P': [4278], '>': [4279]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2989647399', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2025-01-03T11:16:02.257229', 'created_date': '2019-12-05'}