Publication Information

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4496], 'was': [102, 884, 1122, 1341, 1422, 1631, 1693, 1717, 1810, 2004, 2096, 2241, 2268, 2457, 2576, 2737, 2867, 3016, 3155, 3236, 3619, 3897, 3907, 4007, 4034, 4110, 4401], 'truncated': [103, 1559], 'after': [104, 1321, 1560, 1990, 2990, 3434, 3981], 'fourth': [106], 'transmembrane': [107, 550, 2281, 3316], 'helix': [108], 'S4': [109, 588, 617, 629, 1562, 3301, 4173], '(Shaker-iVSD).': [110, 1263], 'Shaker-iVSD': [111, 132, 146, 1265, 1307, 1356, 1421, 1484, 1554, 1570, 1578, 1652, 1745, 1929, 1985, 2027, 2156, 2170, 2234, 2377, 2659, 2803, 3182, 3202, 3394, 3431, 3505, 3582, 3746, 3847, 3849, 3893, 3916, 3947, 3970, 4234, 4293, 4447, 4483, 4520, 4551, 4605], 'showed': [112, 4430], 'significantly': [113, 2927, 3908], 'altered': [114, 2269], 'kinetics': [116, 2113, 4025, 4413, 4518, 4549], 'formed': [118, 565, 582], 'a': [119, 124, 370, 507, 511, 561, 638, 756, 831, 864, 870, 939, 1050, 1056, 1251, 1332, 1436, 1451, 1459, 1531, 1556, 1600, 1623, 1674, 1770, 1785, 2054, 2067, 2309, 2404, 2669, 2691, 3045, 3087, 3106, 3124, 3345, 3492, 3563, 3764, 3875, 4095, 4205, 4431, 4477, 4485, 4536, 4559], 'cation-selective': [120], 'with': [123, 156, 621, 993, 1127, 1819, 1928, 2088, 2098, 2158, 2222, 2244, 2292, 2308, 2385, 2444, 2531, 2658, 2661, 2912, 3038, 3250, 3383, 3403, 3670, 3810, 3882, 3973, 4036, 4119, 4197, 4378, 4423, 4437], 'strong': [125, 2086], 'preference': [126], 'for': [127, 951, 1291, 1350, 1408, 1757, 2125, 2341, 2349, 2418, 2706, 2804, 3151, 3171, 3292, 3446, 3581, 3596, 3611, 3765, 3825, 3836, 3846, 3891, 4142, 4229, 4446, 4625], 'protons.': [128], 'Ion': [129], 'conduction': [130, 4181], 'developed': [133, 1161, 2124], 'despite': [134], 'identical': [135], 'primary': [136], 'sequence,': [137], 'indicating': [138, 2937], 'an': [139, 247, 347, 849, 1175, 1243, 1406, 1428, 1548, 2099, 4438], 'allosteric': [140], 'influence': [141, 301, 422], 'domain.': [145, 1287, 4462], 'also': [147, 1160, 1833, 2242, 3166, 4014], 'displays': [148, 4606], 'pronounced': [149], "'relaxation'.": [150], 'Closing': [151], 'correlates': [155], 'entry': [157, 3719, 4160], 'into': [158, 479, 556, 1049, 1232, 1470], 'relaxation': [159, 1172, 1213, 1226], 'suggesting': [160, 1171, 3080, 4304], 'that': [161, 200, 213, 233, 250, 350, 392, 416, 603, 791, 800, 844, 945, 1193, 2120, 2134, 2149, 2862, 2938, 3081, 3266, 3341, 3382, 4056, 4305, 4330, 4355, 4427, 4481], 'two': [163, 557, 737, 2982, 3979], 'processes': [164], 'related.': [167], 'https://doi.org/10.7554/eLife.18130.001': [168], 'Cells': [171, 1754], 'heart': [174, 482], 'other': [176, 354, 424, 473, 1007, 1156, 2973, 3028, 3295], 'muscles': [177], 'rely': [178], 'on': [179, 433, 891, 1705, 1798, 3142, 3463, 3632], 'electrical': [180, 189, 234, 278, 403, 523], 'signals': [181, 190, 235, 404, 524, 3791, 3978, 4622], 'coordinate': [183], 'their': [184, 990, 1366], 'activity.': [185, 1494], 'They': [186, 543], 'generate': [187], 'these': [188, 2981], 'controlling': [192], 'movement': [194], 'ions': [196, 218, 253, 356, 388, 2974, 3084], 'across': [197, 280, 389], 'membrane': [199, 210, 282, 391, 1413, 1419, 2105, 2198], 'surrounds': [201], 'cell.': [203], 'Proteins': [204], 'called': [205, 268], 'this': [209, 309, 365, 435, 460, 754, 1385, 4207, 4280, 4373], 'form': [211], 'pores': [212, 228], 'allow': [214, 1697], 'particular': [215, 2039], 'types': [216], 'pass': [220, 255, 358], 'through.': [221], 'The': [222, 242, 409, 429, 611, 782, 842, 1540, 1688, 1900, 1963, 2047, 2094, 2174, 2264, 2450, 2708, 2831, 2947, 3148, 3164, 3231, 3641, 3676, 3886, 3987, 4219, 4339, 4394, 4468, 4546, 4582], 'opening': [223, 4398], 'closing': [225], 'tightly': [230], 'controlled': [231], 'so': [232], 'only': [237, 3324], 'generated': [238, 1250, 3551, 3793], 'at': [239, 369, 607, 735, 1334, 1439, 1533, 1622, 1673, 1852, 1874, 1930, 2044, 2075, 2091, 2103, 2127, 2214, 2305, 2465, 2496, 2510, 2540, 2586, 2631, 2765, 2777, 2790, 2845, 3075, 3105, 3474, 3497, 3506, 3953, 4131, 4158, 4245, 4248, 4301], 'specific': [240], 'times.': [241], 'allows': [251, 351], 'potassium': [252, 1239], 'through': [256, 359, 2277, 2975, 3282, 3348, 4182, 4362, 4453], 'membrane.': [258, 361], 'This': [259, 381, 4109, 4498], 'protein': [260, 825], 'made': [262], 'several': [264], 'modules': [265, 418, 799], 'including': [266, 517], 'one': [267, 819, 4323], 'which': [273, 553, 1164, 1458, 3906, 4249], 'senses': [274], 'changes': [275, 395, 663, 1033, 1223, 1268, 1300, 1346, 1417, 2479, 2612, 2755, 3944, 3958, 4585, 4602], 'open': [284, 446, 1148, 2210, 4571], 'or': [285, 483, 1105, 1279, 1660, 1777, 1863, 1941, 2159, 2369, 2441, 2536, 2730, 2849, 2876, 2968, 3210, 3543, 4217, 4329], 'close': [286, 448], 'module.': [289, 500], 'However,': [290, 1220, 2014, 4286], 'it': [291, 598, 1121, 2939], 'not': [293, 862, 1018, 1166, 1270, 2029, 2153, 2333, 2925, 2942, 3008, 3260, 3270, 3655, 3930, 3996, 4093, 4189, 4297, 4391, 4587], 'clear': [294, 3976], 'how': [295, 315, 440, 455, 1021, 4504], "other's": [303], 'structure': [304, 785, 985, 3712, 3729], 'behaviour.': [306, 461], 'To': [307, 1229, 1817, 2559, 2978, 3176, 3457, 4371, 4514], 'address': [308], 'question,': [310], 'Zhao': [311, 330, 412], 'Blunck': [313, 332, 414], 'investigated': [314], 'behaves': [320], 'animal': [322], 'cells': [323, 406, 527, 1743, 1926, 2656], 'when': [324, 372, 2040, 2324], 'module': [327, 458, 851], 'absent.': [329], 'show': [333, 2181], 'that,': [334], 'module,': [341], 'becomes': [346], 'protons': [352, 3152, 3293], 'positively-charged': [355], 'Further': [362], 'experiments': [363, 3139, 3165, 3190], 'reveal': [364], 'new': [366], 'opens': [368], 'main': [374], 'usually': [379], 'closed.': [380], 'may': [382, 476, 1029, 1209, 2953], 'result': [383], 'small': [385], 'leaks': [386, 465], 'cause': [393], 'long-lasting': [394], 'timing,': [398], 'intensity': [399, 4083], 'number': [401], 'organs.': [408], 'findings': [410], 'suggest': [415, 790], 'different': [417, 805, 2381, 3184, 4486], 'more': [425, 450, 2321, 4210, 4404], 'than': [426, 2226, 3223, 3910, 4488, 4554], 'previously': [427], 'thought.': [428], 'next': [430], 'steps': [431, 738, 2065], 'following': [432, 2403, 2690, 3568, 3812], 'from': [434, 1025, 1575, 1595, 1616, 1649, 1741, 1763, 1778, 1824, 1849, 1924, 1984, 2398, 2654, 2668, 2681, 2929, 3065, 3145, 3428, 3494, 3743, 3915, 4540], 'work': [436], 'explore': [439], 'detail': [451], 'examine': [454], 'influences': [459, 4510], 'Investigating': [462], 'whether': [463], 'similar': [464, 2122, 2128, 3346, 4039, 4416], 'occur': [466, 733], 'aid': [477], 'research': [478], 'some': [480], 'inherited': [481], 'neurological': [484], 'disorders': [485], 'where': [486, 857], 'cut': [490], 'short': [491], 'https://doi.org/10.7554/eLife.18130.002': [501], 'Voltage-gated': [503], 'play': [506], 'fundamental': [508], 'role': [509, 4208], 'wide': [512], 'range': [513, 1675, 3361, 4537], 'physiological': [515], 'processes,': [516], 'generation': [519], 'propagation': [521], 'excitable': [526], 'muscle': [529], 'tissues,': [530], 'neurotransmitter': [531], 'release': [532], 'pre-synaptic': [534], 'nerve': [535], 'endings,': [536], 'maintaining': [538], 'cell': [539], 'homeostasis': [540], '(Hille,': [541], '1978).': [542], 'comprise': [544], 'subunits': [546], 'six': [549], 'segments': [551, 572], '(S1–S6),': [552], 'assembled': [555], 'distinct': [559], 'parts:': [560], 'ion-selective': [563], 'combined': [568], 'S5': [569], 'S6': [571, 678], 'voltage-sensing': [579], '(VSDs)': [581], 'helices': [586], 'S1–S4.': [587], 'principal': [592], 'component': [593], 'because': [597, 2033], 'contains': [599], 'positively': [600, 4168], 'charged': [601, 4169], 'residues': [602, 3725], 'periodically': [605], 'aligned': [606], 'every': [608], 'third': [609], 'position.': [610], 'first': [612, 1293], 'arginines': [614, 4170], '(R1-R4)': [615], 'sense': [618], 'interact': [620], 'surrounding': [623], 'electric': [624], 'field,': [625], 'move': [627], 'outward': [630], 'during': [631, 635, 1034, 1904, 1967, 3648, 3998], 'depolarization': [632, 1038], 'inward': [634, 2089, 2238, 2314, 2903, 3059, 3895], 'hyperpolarization': [636, 2407, 2694, 3865], 'combination': [639], 'translation,': [641], 'rotation': [642], 'tilt': [644], '(Faure': [645], 'et': [646, 650, 655, 659, 693, 697, 705, 709, 717, 722, 741, 771, 775, 779, 812, 835, 839, 897, 901, 905, 925, 929, 955, 959, 963, 967, 1081, 1085, 1089, 1093, 1101, 1132, 1136, 1140, 1182, 1186, 1198, 1206, 1377, 1381, 3307, 3311, 3327, 3331, 3335, 3363, 3367, 3651, 4147, 4151, 4256, 4275], 'al.,': [647, 651, 656, 660, 694, 698, 706, 710, 718, 723, 742, 772, 776, 780, 813, 836, 840, 898, 902, 906, 926, 930, 956, 960, 964, 968, 1082, 1086, 1090, 1094, 1102, 1133, 1137, 1141, 1183, 1187, 1199, 1207, 1378, 1382, 3308, 3312, 3328, 3332, 3336, 3364, 3368, 3652, 4148, 4152, 4257, 4276], '2012;': [648, 657, 810, 927, 1087, 1184], 'Li': [649, 958], '2014a,': [652], '2014b;': [653], 'Vargas': [654], 'Yarov-Yarovoy': [658], '2012).': [661], 'These': [662, 3138, 4154], 'mechanically': [665], 'transmitted': [666], 'via': [671, 1302], 'S4–S5': [673], 'linker': [674, 1203, 1340, 1445], 'C-terminal': [677], 'same': [681, 2183, 2459, 2554, 2840, 2855, 2871, 3466], 'neighboring': [683], 'subunit,': [684], 'leading': [685], '(Batulan': [692, 1376], '2010;': [695, 707, 713, 1138, 1379], 'Wall-Lacelle': [696], '2011;': [699, 703, 1079], 'Haddad': [700], 'Blunck,': [702, 746, 1078, 1152, 3966], 'Muroi': [704], 'Long': [708], '2005b;': [711], 'Catterall,': [712], 'Bezanilla,': [714, 3304], '2005;': [715, 743], 'Lu': [716], '2001,': [719], '2002;': [720], 'Labro': [721], '2008).': [724, 1103, 1188], 'Opening': [725], 'has': [729, 767, 913, 1039, 1108], 'been': [730, 768, 914, 982, 1003, 1040, 1109, 3290, 4137], 'shown': [731, 915, 1041, 1110, 1827, 2597, 2887, 3555, 3797, 3870, 4138, 4624], 'least': [736], '(Del': [739], 'Camino': [740], 'Kalstrup': [744], '2013).': [747, 841, 3034], 'addition': [749, 4120, 4288], 'region,': [755], 'direct': [757], 'structural': [758, 889, 1245, 1281], 'functional': [760, 1247], 'interaction': [761], 'VSD': [764, 793, 817, 846, 859, 910, 947, 1035, 1071, 1180, 1212, 1241, 3284], 'demonstrated': [769], '(Lee': [770, 954], '2009a;': [773], 'Li-Smerin': [774], '2000;': [777], 'Petitjean': [778], '2015).': [781], 'topology': [783, 1497], 'make': [797], 'up': [798], 'can': [801], 'be': [802, 1112, 1125, 1174, 1271, 2030, 2954, 4089, 4107, 4140, 4227], 'adapted': [803], 'scenarios': [806], '(Blunck': [807, 3650], 'Batulan,': [809], 'Kim': [811], '2014).': [814, 3337, 4153, 4258], 'Chimeras': [815], 'another': [824], 'were': [826, 1329, 1358, 1468, 1593, 1611, 1668, 1726, 1755, 1832, 1913, 1976, 1986, 2137, 2285, 2390, 2552, 2590, 2666, 2760, 2838, 2853, 2880, 2896, 3031, 3140, 3217, 3469, 3516, 3550, 3730, 3792, 3929, 3938, 4414, 4552, 4567], 'able': [827, 3931, 3939], 'gate': [829], 'voltage-dependent': [832, 1492, 4608], 'fashion': [833], '(Lu': [834], '2001;': [837], 'Arrigoni': [838], 'notion': [843, 4354], 'acts': [847], 'as': [848, 875, 989, 1011, 1242, 1405, 1728, 1826, 1835, 2189, 2204, 2247, 2460, 2555, 2841, 2856, 3212, 3556, 3798, 3874, 4237, 4502], 'independent': [850, 1244], 'further': [853, 2147, 4111], 'supported': [854], 'proteins': [856, 1009, 1048], 'linked': [861], 'but': [867, 2473, 2606, 2749, 4005, 4085], 'instead': [868], 'cytosolic': [871], 'enzymatic': [872], 'such': [874, 944, 1010], 'voltage-sensitive': [877], 'phosphatase': [878, 923], 'Ciona': [880], 'intestinalis': [881], '(Ci-VSP).': [882], 'It': [883], 'possible': [885, 1022], 'carry': [887], 'out': [888], 'studies': [890, 987, 1190], 'isolated': [892, 1259], 'sensor': [894, 1261, 4061, 4461], '(Li': [896], '2014a;': [899], 'Chakrapani': [900], '2008;': [903], 'Jiang': [904], '2003),': [907], 'Ci-VSP': [912, 1012], 'function': [917, 986, 3565, 3876], '(Labro': [924, 1181], 'Murata': [928], '2005).': [931], 'Finally,': [932], 'proton': [935, 952, 2258, 2265, 2273, 2310, 2963, 3018, 3022, 3099, 3320, 4180], '(Hv)': [937], 'lack': [938], 'separate': [940], 'altogether': [943], 'its': [946, 1073, 3622, 4317], 'directly': [949, 1004, 4333], 'responsible': [950, 4141, 4228], 'permeation': [953, 2971, 3234, 4337, 4358], '2009b;': [957], '2015;': [961, 3309], 'Ramsey': [962], '2006;': [965, 3329, 3333, 3365, 4149], 'Sasaki': [966, 3330, 3366], '2006).': [969], 'view': [971], 'nature': [975], 'channels,': [979, 1218, 2211, 4129], 'VSDs': [980, 1044], 'have': [981, 1002, 1030, 1191, 3289, 4136], 'largely': [988], 'own': [991, 3623], 'entity': [992], 'they': [1001, 4574], 'compared': [1005], 'VSD-containing': [1008], 'Hv': [1014, 3352], 'channels.': [1015, 1702], 'We': [1016, 2118, 3338, 3380], 'do': [1017], 'know,': [1019], 'however,': [1020], 'restraint': [1023], 'forces': [1024], 'obscured': [1031], 'conformational': [1032, 1222, 1267, 1299, 1345, 3943, 3957], 'activation.': [1036], 'Prolonged': [1037], 'reconfigure': [1043], 'numerous': [1046], 'stable': [1051], "'relaxed'": [1052], 'state,': [1053, 4572], 'resulting': [1054, 2175, 4547], 'hyperpolarizing': [1057], 'shift': [1058, 1107, 1159], 'dependence': [1062, 2070, 2188, 4396], 'both': [1064, 3117], 'closure': [1066], 'return': [1068], 'resting': [1074], 'position': [1075, 1322, 1335, 1440, 1534, 3498, 3954, 4132, 4340], '(Haddad': [1076, 1150, 3964], 'Piper': [1080], '2003;': [1083], 'Tan': [1084], 'Olcese': [1088], '1997;': [1091, 1134], 'Kuzmenkin': [1092], '2004;': [1095, 3305], 'Bruening-Wright': [1096], 'Larsson,': [1098], '2007;': [1099], 'Villalba-Galea': [1100, 1185], 'Relaxation': [1104], 'mode': [1106, 1158], 'influenced': [1113], 'state': [1116, 1149, 4268], 'domain;': [1120], 'observed': [1123, 2017, 2048, 2190, 2243], 'correlated': [1126, 3669], 'slow': [1128, 2109, 4607], 'C-type': [1129, 1550], 'inactivation': [1130], '(Olcese': [1131], 'Cuello': [1135], 'Männikkö': [1139], '2005)': [1142], 'stabilization': [1145], '2011).': [1153, 3967], 'On': [1154], 'hand,': [1157], 'Ci-VSP,': [1163], 'does': [1165, 1388], 'possess': [1167], 'any': [1168, 1266, 1273, 3168], 'property': [1177], 'Recent': [1189], 'suggested': [1192], 'N-terminal': [1195, 1447], 'tail': [1196], '(Tan': [1197], '2012)': [1200], 'S3-S4': [1202, 1339], 'length': [1204], '(Priest': [1205], '2013)': [1208], 'affect': [1210], 'hERG': [1215], 'respectively.': [1219, 4201], 'related': [1224, 3959], 'remain': [1227], 'unknown.': [1228], 'gain': [1230], 'insights': [1231], 'mechanisms': [1235], 'unit,': [1248], 'we': [1249, 1289, 1397, 1453, 2168, 2255, 2984, 3186, 3370, 3928, 3937, 4238, 4375, 4425, 4523], 'deletion': [1255, 1386, 1557], 'mutant,': [1256], 'would': [1269, 4076, 4086, 4106, 4177, 4281], 'affected': [1272], 'longer': [1274, 1390, 4088], 'load': [1278], 'constraints': [1282], 'imposed': [1283], 'report,': [1290], 'time,': [1294], 'currents': [1297, 1573, 1592, 1610, 1643, 1667, 1739, 1847, 1903, 1922, 1966, 1982, 2025, 2037, 2050, 2084, 2090, 2123, 2136, 2151, 2176, 2185, 2221, 2315, 2379, 2389, 2530, 2565, 2652, 2665, 2895, 2904, 2931, 3095, 3281, 3416, 3422, 3468, 3861, 3896, 3917, 3935, 3963, 4118, 4422], 'monitored': [1301], 'fluorescence': [1303, 3425, 3634, 3643, 3665, 3977, 3993, 4016, 4032, 4053, 4082, 4103, 4525, 4548, 4584, 4609, 4621], 'Shaker-iVSD.': [1305, 2013, 4604], 'forms': [1308], 'conducting': [1310, 1394, 2102, 4284], 'pore-deletion': [1314], 'mutant': [1315, 1387, 1558, 4388], 'Shaker-iVSD,': [1316, 4192, 4279], '(S5-S6)': [1320], 'I384': [1323], 'almost': [1325], 'complete': [1327, 1698, 4495], 'C-terminus': [1328, 1568], 'removed': [1330], 'cysteine': [1333, 1437, 1532], 'A359': [1336], 'introduced': [1342, 1438, 1469], 'follow': [1344, 3344], '(Figure': [1347, 1474, 1998, 2020, 2071, 2114, 2131, 2142, 2194, 2230, 3096, 3136, 3229, 3274, 3397, 3983, 4009, 4046, 4123, 4174, 4417, 4448, 4556], '1a,': [1348], 'bottom,': [1349], 'details': [1351], 'see': [1352, 3406, 3513], 'methods).': [1355], 'mutants': [1357], 'transiently': [1359], 'expressed': [1360, 2169], 'Xenopus': [1362, 2166, 2192, 2206, 2228], 'laevis': [1363], 'oocytes,': [1364, 2167, 2207], 'electrophysiological': [1367], 'properties': [1368], 'examined': [1369], 'using': [1370, 1583, 1599, 1746, 1885, 1949, 1993, 2412, 2699, 2827, 3193, 3441, 3552, 3732, 3758, 3794, 3948, 4615], 'cut-open': [1372, 1584, 1646, 1887, 1995, 2413, 2828, 3195, 3442, 3759, 4616], 'oocyte': [1373, 1585, 1647, 1888, 1996, 2414, 2829, 4617], 'voltage-clamp': [1374, 1403, 1648, 3949, 4614], 'technique': [1375, 1891, 1954, 1997, 2415, 2703, 3443, 3760], 'Taglialatela': [1380], '1992).': [1383], 'Because': [1384], 'no': [1389, 2121, 4087], 'contain': [1391], 'used': [1398, 1454, 1521, 1727, 1834], 'current': [1400, 1597, 1606, 1708, 1801, 1822, 2240, 2363, 3015, 3060, 3199, 3268, 3392, 3521, 3677, 3682, 3740, 4044, 4066, 4243, 4300, 4472], 'measurements': [1401], 'fluorometry': [1404], 'indicator': [1407], 'trafficking': [1409], 'plasma': [1412], 'responsiveness': [1415], 'potential.': [1420], 'site-directed': [1423], 'fluorescently': [1424], 'labeled': [1425, 3972], 'attaching': [1427], 'extrinsic': [1429], 'fluorescent': [1430, 3495], 'probe': [1431], '(tetramethyl-rhodamine': [1432], 'maleimide,': [1433], 'TMRM)': [1434], 'A359C': [1441, 1467, 1535, 3499, 3955], 'S3–S4': [1444, 1538], 'just': [1446], 'S4.': [1449, 3501], 'As': [1450], 'reference,': [1452], 'Shaker-A359C-W434F': [1455], '(Shaker-W434F),': [1456], 'mutation': [1460, 1541], 'rendering': [1461], 'non-conducting': [1464, 4322], '(W434F)': [1465], 'background': [1471, 3658], 'H4-IR': [1473], '1a).': [1475], 'Figure': [1476, 2352, 2354, 2557, 2843, 2892, 3401, 4595], '1': [1477, 3068, 3404], 'Download': [1478, 2356, 3408, 4597], 'asset': [1479, 1481, 2357, 2359, 3409, 3411, 4598, 4600], 'Open': [1480, 2358, 3410, 4599], 'Expression': [1482], 'lacking': [1485], 'sufficient': [1489], 'reconstitute': [1491], '(a)': [1495, 3420, 4619], 'Top:': [1496], 'K+': [1500, 2812, 3211], 'channel.': [1501, 1553, 2977], 'Amino': [1502], 'acid': [1503, 2432, 2733], 'positions': [1504], 'relevant': [1505], 'present': [1508, 1524], 'study': [1509], 'highlighted': [1511], 'yellow.': [1513], 'Middle:': [1514], 'constructs': [1517], '(Shaker-W434F': [1518], 'Shaker-iVSD)': [1520], 'study.': [1525], 'Thiol-reactive': [1526], 'fluorophores': [1527], 'attached': [1529, 4069], 'linker.': [1539], 'W434F': [1542], 'region': [1546], 'produces': [1547], 'instantly': [1549], 'inactivated': [1551], 'helix.': [1563], 'Bottom:': [1564], 'Sequence': [1565], '(b)': [1571, 2524, 3485], 'Gating': [1572, 1609, 1981], 'recorded': [1574, 1644, 1740, 1823, 1848, 1923, 2653, 2932, 3203, 3427, 3742], 'oocytes': [1576, 1650, 1825, 1851, 1873, 2141, 2193, 2229, 3192, 3196, 3429, 3744, 4612], 'expressing': [1577, 1651, 1744, 3430, 3745, 3969], '(top)': [1579], 'Shaker-W434F': [1581, 2019, 2126, 4555], '(bottom)': [1582], 'clamp.': [1587], 'Leak,': [1588], 'background,': [1589], 'capacitive': [1591], 'subtracted': [1594], 'traces': [1598, 1709, 1802, 3426, 3487, 3741, 4526], 'P/4': [1601], 'protocol.': [1602, 1608], 'Inset': [1603], 'shows': [1604, 1710, 1803, 4480], 'step': [1607, 3864], 'elicited': [1612, 1669, 2591, 2667, 2881, 3862, 4524], 'test': [1614, 1691, 2059, 2560], 'pulses': [1615, 1692, 1912, 1975, 2060, 2396, 2679, 4534], '−100': [1617], 'mV': [1618, 1621, 1680, 1683, 1765, 1768, 1780, 1783, 1794, 1857, 1865, 1879, 1935, 1943, 2064, 2216, 2340, 2348, 2402, 2411, 2490, 2504, 2518, 2674, 2685, 2688, 2698, 2764, 2776, 2789, 3069, 3074, 3129, 3580, 3590, 3595, 3605, 3610, 3820, 3830, 3835, 3868, 4542], '+120': [1620, 2401], 'holding': [1624, 1665, 1771, 1786, 1853, 1875, 1931, 2041, 2078, 2213, 2670, 4560], 'potential': [1625, 1772, 1787, 2043, 2079, 2199, 2331, 2671, 2988, 3012, 4561], '−90': [1627, 1789, 1864, 1942, 2045, 4302, 4563], 'mV.': [1628, 2046, 4545], 'Zero': [1629, 1715, 1808, 3448], 'level': [1630, 1716, 1809, 2130, 3449], 'indicated': [1632, 1718, 1811, 3451], 'red': [1635, 1721, 1814, 2814], 'dashed': [1636, 1722, 1815, 3455], 'line.': [1637, 1723, 1816, 3456], '(c': [1638], 'd)': [1640], 'Representative': [1641, 1737], 'ionic': [1642, 1738, 1821, 1921, 2036, 2049, 2184, 2220, 2239, 2993, 3005, 3188, 3391, 3415, 3467, 3639, 3851, 3860, 4471, 4593], 'Shaker-W434F.': [1654], 'At': [1655, 2482, 2615, 4558], 'depolarized': [1656, 1756, 2077], '(0': [1657], 'mV,': [1658, 1663, 1775, 1790, 2082, 3134, 4303, 4564], 'top)': [1659], 'hyperpolarized': [1661, 2092, 4405], '(−90': [1662, 2201], 'bottom)': [1664, 1791], 'potentials,': [1666], 'pluses': [1672], '−180': [1677, 2399, 4541], '+140': [1679], '10': [1682, 1793, 2063, 2579, 2687, 2717, 3049, 3174, 3544, 3612], 'increments': [1684], 'without': [1685], 'leak': [1686], 'substraction.': [1687], 'interval': [1689], '5': [1694], 's': [1695], 'recovery': [1699], 'An': [1703, 1796], 'inset': [1704, 1797, 1897, 1960, 2417, 2705, 2890, 3445, 3762, 3799], 'top': [1706, 1799], 'corresponding': [1712, 1805, 4346, 4583], 'protocols.': [1714, 1807], 'NMDG+-based': [1724, 1830, 2370, 2543, 2832, 2858, 2922], 'solutions': [1725, 1831, 2291, 2368, 2547, 2713, 2837, 2852, 3121, 3206], 'external': [1730, 2326, 2382, 2544, 2574, 2805, 2833, 2851, 2859, 2921, 2934, 3042, 3118, 3205, 3227, 3254, 3378, 3418, 3539, 3844, 4270, 4290], 'internal': [1732, 2455, 2463, 2546, 2836, 3120], 'solutions,': [1733, 1840], 'pHin/pHout': [1734, 1841, 2483, 2497, 2511, 2541, 2766, 2778, 2791, 2846], '7.35/7.35.': [1735, 1842, 2542, 2847], '(e)': [1736, 3628], 'HEK293': [1742, 1925, 2172, 2655, 3146], 'whole-cell': [1748, 1951, 2178, 2700, 3143], 'configuration': [1749], 'patch-clamp': [1752, 2179], 'technique.': [1753, 2830, 3197, 4618], '500': [1758], 'ms': [1759, 1908, 1971, 2058, 2394, 2406, 2677, 2693, 3480, 4531], 'potentials': [1761, 1854, 1876, 1932, 2106, 2323, 4406, 4539], 'ranging': [1762, 2397, 2680], '–140': [1764, 2682], '+100': [1767, 2684], '(at': [1769, 1784], '0': [1774, 1856, 1878, 1934, 2081, 2215, 2673], 'top),': [1776], '−140': [1779], '+80': [1782], 'increments.': [1795], 'compare': [1818], 'c,': [1829], 'extracellular': [1837, 2253, 2293, 2711, 3215], 'intracellular': [1839, 2302, 2709], '(f)': [1843, 2909, 3695], 'I-V': [1844, 1918], 'relations': [1845, 1919, 2528, 3531, 3770], 'Shaker-iVSD-injected': [1850], '(black': [1858, 1936, 2491, 2641, 2768, 2807, 3774], 'triangle,': [1859, 1867, 1881, 1937, 1945, 2492, 2506, 2520, 2627, 2642, 2769, 2781, 2794, 2915, 3775, 3782], 'n': [1860, 1868, 1882, 1938, 1946, 2493, 2507, 2521, 2628, 2643, 2770, 2782, 2795, 2809, 2816, 2824, 2916, 3776, 3783, 3903, 3923], '=': [1861, 1869, 1883, 1939, 1947, 2486, 2494, 2500, 2508, 2514, 2522, 2621, 2629, 2637, 2644, 2771, 2783, 2796, 2810, 2817, 2825, 2917, 3078, 3585, 3600, 3615, 3777, 3784, 3904, 3924, 4408], '14)': [1862], '(red': [1866, 1944, 2519, 2626, 2780, 3781], '13),': [1870], 'H2O-injected': [1872, 2140], '(blue': [1880, 2505, 2793], '5)': [1884, 3778, 3785], 'clamp': [1890, 1953, 2702, 4533], '(see': [1892, 1955, 2416, 2704, 3444, 3482, 3761], 'protocol': [1893, 1956, 2596, 2886, 3512, 3554, 3796], 'upper': [1896, 1959], 'c).': [1899, 3400], 'mean': [1901, 1964], 'steady-state': [1902, 1965], 'last': [1906, 1969], '50': [1907, 1970], 'command': [1911, 1974], 'plotted': [1914, 1977, 2906, 3873], 'versus': [1915, 1978, 2907, 4443], 'voltage.': [1916, 1979, 2908], '(g)': [1917, 3738], 'transfected': [1927, 2657], '8)': [1940], '4)': [1948], 'patch': [1952, 2701], 'e).': [1962, 4049], 'https://doi.org/10.7554/eLife.18130.003': [1980], 'arising': [1983], 'detected': [1987], '4–5': [1988], 'days': [1989, 3980], 'cRNA': [1991], 'injection': [1992, 3982], '1b,': [1999], 'top).': [2000], 'Our': [2001], 'initial': [2002], 'objective': [2003], 'obtain': [2006], 'charge-voltage': [2009], '(QV)': [2010], 'relation': [2011, 4019], 'unlike': [2015], 'those': [2016], '1b': [2021], 'bottom),': [2022], 'could': [2028], 'estimated': [2031], 'reliably': [2032], 'substantial': [2035], 'series': [2055], '250': [2057, 2393, 2676, 3479, 4530], 'applied': [2061], 'exhibited': [2066, 2085, 3975], 'weak': [2068], '1c).': [2072], 'contrast,': [2074], 'rectification': [2087, 2225], 'potentials.': [2093], 'phenotype': [2095], 'consistent': [2097], 'channel,': [2101], 'negative': [2104], 'very': [2108, 4415, 4578], 'activation': [2110, 3999, 4024], 'deactivation': [2112, 4006], '1c': [2115], 'f).': [2117], 'confirmed': [2119], 'expression': [2129, 2161], '1d)': [2132], 'endogenous': [2135, 2163], 'negligible': [2138], '1f).': [2143], 'verify': [2148], 'caused': [2154, 4064, 4310], 'assembling': [2157], 'inducing': [2160], 'cells.': [2173, 3147], 'recordings': [2180, 3490], '1e).': [2195], 'Holding': [2196], 'polarized': [2200], 'mV)': [2202], 'led,': [2203], 'constitutively': [2209], 'whereas': [2212], 'led': [2217], 'hyperpolarization-activated': [2219], 'slightly': [2223], 'less': [2224], '1g).': [2231], 'Selectivity': [2232, 2360], 'Since': [2236, 3351], 'NMDG+': [2245, 2290, 2567, 2806, 2902, 3037, 3083, 3108, 3154, 3225], '(N-methyl-D-glucamine)': [2246], 'dominant': [2249], 'solution,': [2254, 2936], 'tested': [2256, 3371, 4382], 'selectivity': [2259, 3180], 'Shaker-iVSD-induced': [2262, 2362, 2564, 3094, 3263, 3414], 'current.': [2263, 3640, 4594], 'driving': [2266], 'force': [2267], 'shifting': [2271], 'reversal': [2274, 2330, 2987, 3011], 'potential,': [2275], 'E(H+),': [2276], 'alterations': [2278], 'pH': [2282, 2294, 2303, 2342, 2350, 2383, 2434, 2439, 2448, 2466, 2587, 3001, 3077], 'gradient.': [2283], 'Oocytes': [2284], 'bathed': [2286], '70': [2288, 2426], 'mM': [2289, 2535, 2550, 2570, 2580, 2584, 2864, 3050, 3053], 'modulated': [2295], '9.5,': [2297], '7.5': [2298], '4.5': [2300, 2343], 'maintained': [2304], '7.5.': [2306, 2467], 'Consistent': [2307], 'selective': [2311, 3019], 'pore,': [2312, 4164], 'increased': [2316], 'E(H+)': [2318, 2335, 2952], 'shifted': [2319, 3062, 4402], 'positive': [2322], 'decreasing': [2325], 'pH,': [2327], 'although': [2328], 'did': [2332, 2924, 3259, 3995, 4294, 4390, 4586], 'reach': [2334], 'completely': [2336], '(12.5': [2337], '±': [2338, 2346, 2488, 2502, 2516, 2623, 2639, 2762, 2774, 2787, 3067, 3072, 3127, 3132, 3574, 3578, 3588, 3593, 3603, 3608, 3818, 3823, 3828, 3833], '1.6': [2339, 2503], '−5.4': [2345, 2515], '1.8': [2347, 2788, 3133], '9.5;': [2351], '2a).': [2353], '2': [2355, 3540, 3597], 'high': [2365, 3113, 3657], 'buffer': [2366, 3114], '(HB)': [2367], 'solutions.': [2371, 2387, 2663], '(a)Top.': [2372], 'Normalized': [2373, 2526, 2648, 3198, 3529, 3768], 'IV': [2374, 2471, 2527, 2604, 2649, 2747], 'relationships': [2375, 2650], 'induced': [2378], 'under': [2380, 4613], 'conditions': [2384], 'HB': [2386, 2421, 2454, 2462, 2662, 2712], 'Tail': [2388, 2664], 'evoked': [2391], '200': [2405, 2692], 'prepulse': [2408, 2695], '−120': [2410, 2697], 'protocol).': [2419, 2707, 3447, 3766], 'External': [2420], 'solution': [2422, 2456, 2464, 2575, 2834, 2860, 2923, 3043, 3228, 3255], 'contained': [2423, 2548, 2714], '(in': [2424, 2715], 'mM)': [2425, 2716, 3111], 'NMDG+,': [2427, 2718], 'either': [2429, 2720, 3208, 4215, 4306], '180': [2430, 2436], 'acetic': [2431, 2732], '(for': [2433, 2438, 2447, 2723, 2728, 2734, 3511], '4.5),': [2435], 'HEPES': [2437, 2722], '7.5),': [2440, 2725], '136': [2442], 'CHES': [2443], '44': [2445], 'D-sorbitol': [2446, 2996, 3039], '9.5).': [2449], 'composition': [2451], 'Bottom.': [2468, 2601, 2744], 'Same': [2469, 2602, 2745], 'normalized': [2470, 2603, 2746, 2897, 3058, 3424, 3470, 3517, 3620, 3686, 3857, 3992], 'relationships,': [2472, 2605, 2748], 'zoomed': [2474, 2607, 2750], 'emphasize': [2477, 2610, 2753], 'Vrev.': [2481, 2614, 2757], '7.5/7.5,': [2484], 'Vrev': [2485, 2499, 2513, 2620, 2636, 2758, 2950, 2989, 3064, 3125], '−0.14': [2487], '0.18': [2489], '56);': [2495], '7.5/4.5,': [2498], '12.5.2': [2501], '5);': [2509], '7.5/9.5,': [2512], '1.76': [2517], '5).': [2523], 'Top.': [2525, 2647], 'NMDG+in/NMDG+out': [2532, 2616, 2632], '115': [2533, 2537, 2549, 2569, 2617, 2633, 2863, 3052], 'mM/10': [2534, 2618], 'mM/115': [2538, 2634], 'mM,': [2539, 2619, 2635], 'NMDG-MeSO3': [2551, 2571, 2581, 2935], '1b–d.': [2558], 'permeability': [2562, 3150, 3170], 'ions,': [2568], 'replaced': [2577, 2868], '210': [2583], 'D-sorbitol,': [2585], '7.35.': [2588], 'Currents': [2589, 2879, 3515], 'pulse': [2595, 2885, 3481], 'inset.': [2600, 3557], '−62.6': [2622], '2.5': [2624, 3073, 3819], 'nmV': [2625], '4);': [2630], '−0.8': [2638], '1.1': [2640, 2775, 3128], '4).': [2645], '(c)': [2646, 3502], 'cDNA': [2660], 'increments,': [2689], '24': [2721], 'PH': [2724], '56': [2726], 'MES': [2727], 'pH5.5),': [2729], '35': [2731], 'pH4.5).': [2735], 'Osmolarity': [2736], 'adjusted': [2738], '300~320': [2740], 'mOsm': [2741], 'D-sorbitol.': [2743], 'values': [2759, 3678], '0.5': [2761], '0.2': [2763, 3829], '7.5/7.5': [2767], '9),': [2772], '−7.0': [2773, 3126], '5.5/7.5': [2779], '6),': [2784], '−34.9': [2786, 3131], '4.5/7.5': [2792, 3104], '10).': [2797], '(d–e)': [2798], 'Comparison': [2799], 'conductance': [2801], 'triangles,': [2808, 2815, 2823], '12),': [2811], '(f,': [2813], '7)': [2818, 2826, 2918], 'Na+': [2820, 3209], '(g,': [2821], 'blue': [2822], '1b–d': [2844], 'Na+-based': [2848], 'K+-based': [2850], 'except': [2861], 'NMDG-': [2865], 'MeSO3': [2866, 2875, 2911], 'concentration': [2872, 2964, 3023, 3047, 3109], 'NaOH-': [2874], 'KOH-': [2877], 'MeSO3.': [2878], '1c,': [2893], 'relative': [2898, 3149, 3179, 3625, 3633, 3642, 3664, 4031, 4052, 4102], 'maximum': [2901], 'Replacing': [2910], 'chloride': [2913, 3251], '(green': [2914], 'exhibit': [2926], 'difference': [2928], 'likely': [2941, 4211], 'carried': [2943, 3271], 'anions.': [2945], 'https://doi.org/10.7554/eLife.18130.004': [2946], 'discrepancy': [2948], 'due': [2955, 2969], 'imperfect': [2958], 'control': [2959, 3583], 'local': [2962], 'near': [2965], 'membrane,': [2967], 'distinguish': [2979], 'possibilities,': [2983], 'measured': [2985], 'reducing': [2991], 'strength': [2994, 3006], 'dilution': [2997], 'keeping': [2999], 'constant.': [3002], 'Reducing': [3003], 'should': [3007], 'alter': [3009, 3261, 3997], 'if': [3013], 'perfectly': [3017], 'since': [3020], 'remains': [3024, 3645], 'constant': [3025, 3646], 'all': [3027, 3407], 'concentrations': [3030, 3115, 3385, 3508], 'reduced': [3032, 3396, 4051], '(DeCoursey,': [3033], 'Substitution': [3035], 'final': [3046], '(versus': [3051], 'cytosolic)': [3054], 'substantially': [3055], 'decreased': [3056], '−1': [3066], '−62.5': [3071], 'symmetric': [3076], '7.35,': [3079], 'even': [3082, 3647], 'certain': [3088], 'extent': [3089], 'permeant': [3090], 'charge': [3091], 'carriers': [3092], '2b).': [3097], 'A': [3098, 3660, 4050], 'gradient': [3100], 'pHin/pHout5.5/7.5': [3102], 'low': [3107], '(10': [3110], 'resulted': [3122], 'respectively': [3135], '2c).': [3137], 'performed': [3141, 3187], 'patches': [3144], 'over': [3153, 4213], 'PH/PNMDG': [3156], '~': [3157], '1400': [3158], 'according': [3159, 3705], 'Goldman-Hodgkin-Katz': [3162], 'equation.': [3163, 3885], 'excluded': [3167], 'significant': [3169], 'anions': [3172, 3273], '(symmetric': [3173], 'mM).': [3175], 'identify': [3177], 'cations,': [3185], 'substitution': [3189], 'amplitudes': [3200, 3683, 3858], 'containing': [3207, 3226], 'predominant': [3214], 'cation': [3216], '1.35': [3218], '1.54': [3220], 'times': [3221], 'higher': [3222, 4433], '2d–e).': [3230], 'efficiency': [3235], 'P(H+)': [3237], '>>': [3238], 'P(K+)': [3239], '≈': [3240], 'P(Na+)': [3241], '>': [3242], 'P(NMDG+).': [3243], 'Replacement': [3244], 'anion': [3247], 'mesylate': [3248], '(MeSO3−)': [3249], '(NMDG-MeSO3': [3256], 'vs': [3257], 'NMDG-Cl)': [3258], 'current,': [3264], 'confirming': [3265, 4450], '2f).': [3275], 'Permeation': [3276], 'pathway': [3277, 4361, 4452], 'iVSD': [3279, 4466], 'Ionic': [3280, 3421, 3739], 'described': [3291], 'cations': [3296, 3343], 'upon': [3297, 4580], 'mutations': [3298], 'along': [3299], '(Starace': [3302], 'Moreau': [3306], 'Tombola': [3310], '2005),': [3313], 'Hv1': [3319, 3714, 4128, 4250, 4368], 'consist': [3322], 'S1-S4': [3325], '(Ramsey': [3326, 3362, 4146], 'Takeshita': [3334, 4150], 'thus': [3339, 3668, 4092, 4178], 'expected': [3340], 'path': [3347], 'VSD.': [3350], 'blocked': [3355, 4254], 'Zn2+': [3357, 3387, 3631, 4004, 4063, 4075, 4122, 4144, 4273, 4291, 4309, 4332, 4436], 'micromolar': [3360], '2006),': [3369], "Shaker-iVSD's": [3372], 'sensitivity': [3373, 4145, 4232], 'application': [3376, 3436], 'Zn2+.': [3379, 3527, 3694], 'found': [3381, 4426], 'increasing': [3384, 3507, 4037], '(0–20': [3388], 'µM),': [3389], 'continuously': [3395], '3a': [3398], '3': [3402], 'supplement': [3405, 4125], 'Inhibition': [3412], 'ZnCl2.': [3419, 3510, 3547, 3789, 3837], 'before': [3432], '2~20': [3438], 'µM': [3439, 3756, 3788, 3919, 4442, 4445], 'ZnCl2': [3440, 3462, 3757, 3845, 3878, 3890], 'grey': [3454], 'illustrate': [3458], 'effects': [3460], 'kinetics,': [3464], 'value': [3473, 3689, 3888, 3913], 'end': [3476], 'lower': [3483, 3909, 4220, 4231], 'inset).': [3484], 'Fluorescence': [3486, 3548, 3790], 'obtained': [3493, 3914], 'labeling': [3496], 'atop': [3500], 'IV-relations': [3503], 'a).': [3514], 'maximal': [3520, 3624, 3681], 'amplitude': [3522, 4045], '(d)': [3528], 'FV': [3530, 3769, 4027], '(black)': [3535, 3751], 'presence': [3537, 3753, 3780, 4002], 'μM': [3541, 3545, 3598, 3613], '(red)': [3542, 3754], '(green)': [3546], 'curves': [3549, 3559, 3803, 3840], 'Smooth': [3558, 3802], 'fits': [3561, 3806], 'Boltzmann': [3564, 3805], 'yielding': [3566], 'V1/2': [3569, 3813], 'dV': [3571, 3815], 'values:': [3572, 3816], '−88.2': [3573], '1.2': [3575], '32.2': [3577], '1.7': [3579], '(n': [3584], '6);': [3586, 3601], '−89.6': [3587], '2.3': [3589], '32.8': [3592], '2.6': [3594], 'ZnCl2(n': [3599, 3614], '−98.4': [3602], '2.9': [3604], '37.5': [3607], '2.0': [3609], '6).': [3616, 3925], 'Each': [3617], 'curve': [3618], 'change': [3626, 3635, 3644, 3666, 3994, 4033, 4054, 4098, 4104], 'dF/F.': [3627], 'Effect': [3629], '(dF/F,': [3636], 'grey)': [3637], 'bleaching': [3649], '2004),': [3653], 'assuming': [3654], 'too': [3656], 'fluorescence.': [3659], 'reduction': [3661, 4115], 'immobilization': [3671, 4057], 'sensors.': [3675], 'c': [3685], 'Position': [3696], 'H140': [3698, 4133, 4193, 4348], '(S2)': [3699], 'H193': [3701, 4135, 4195], '(S3-S4': [3702], 'linker;': [3703], 'numbering': [3704], 'human': [3707], 'Hv1)': [3708], 'crystal': [3711, 3728], '(PDB:': [3715], '3WKV)': [3716], 'pore.': [3723, 4184], 'Missing': [3724], 'modeled': [3731], 'Modeller': [3733], '(Sali': [3734], 'Blundell,': [3736], '1993).': [3737], 'D277H': [3747, 3850, 3894], '0.1': [3755, 3787], '(h)': [3767], 'd.': [3801], '−99.0': [3817], '25.9': [3822], '1.3': [3824], 'control;': [3826], '−110.4': [3827], '25.7': [3832], '1.9': [3834], '(i)': [3838], 'Dose-response': [3839], 'inhibition': [3842, 3901, 3921], 'currents.': [3852], 'Data': [3853], 'points': [3854], 'correspond': [3855], '−150': [3867], '(As': [3869], 'a),': [3872], 'concentration,': [3879], 'fitted': [3881], 'Hill': [3884], 'IC50': [3887, 3912, 4439], '158.4': [3898], 'nM': [3899], '(maximum': [3900, 3920], '79%,': [3902], '5),': [3905], '6.04': [3918], '80%,': [3922], 'https://doi.org/10.7554/eLife.18130.005': [3926], 'While': [3927, 4022, 4185, 4411], 'record': [3933], 'reliably,': [3936], 'trace': [3941], 'occurring': [3945], 'fluorometry.': [3950], 'Attaching': [3951], 'TMRM': [3952], 'reports': [3956], 'Oocytes,': [3968], 'TMRM,': [3974], '3b': [3984, 4010, 4047], 'd).': [3986, 4012], 'time': [3988], 'course': [3989], 'slowed': [4008], 'Accordingly,': [4013, 4100], '(FV)': [4018], 'remained': [4020, 4028], 'unaltered.': [4021], 'unaltered,': [4029], 'diminished': [4035], 'Zn2+-concentration': [4038], 'decrease': [4042], 'indicates': [4055], 'decrease.': [4067], 'Fluorophores': [4068], 'sensors': [4072], 'immobilized': [4073], 'still': [4077, 4244], 'contribute': [4078], 'total': [4081], '(F)': [4084], 'displaced': [4090], 'display': [4094], 'dependent': [4097], '(dF).': [4099], 'dF/F': [4105], 'lower.': [4108], 'validated': [4112], '3—figure': [4124], '1).': [4126], 'histidines': [4130, 4155, 4187], 'positioned': [4157], 'right': [4165], 'above': [4166], '3f)': [4175], 'prevent': [4179], 'align': [4196], 'F280': [4198, 4202], 'E335,': [4200], 'unlikely': [4203], 'coordinates': [4204], 'Zn2+,': [4206, 4236, 4424], 'taken': [4212], 'D277': [4216, 4377], 'E283.': [4218], 'affinity': [4221, 4434], 'glutamate': [4223], 'aspartate': [4225], 'might': [4226], 'find': [4239], '~40%': [4240], '20': [4246], 'µM,': [4247], 'already': [4252, 4568], 'fully': [4253], '(Takeshita': [4255], 'Wild': [4259], 'type': [4260], 'stabilized': [4264], 'closed': [4267, 4575], '(300': [4271], 'µM)': [4272], '(Boland': [4274], '1994).': [4277], 'reflect': [4282], 'state.': [4285], 'reduce': [4295], 'increase': [4298], 'binding': [4307], 'adopt': [4316], "'native'": [4318], 'conformation': [4319, 4487], '(i.e.': [4320], 'full': [4326], 'channel)': [4328], 'blocks': [4334], 'pathway.': [4338], 'D277/E283': [4342], 'E335': [4344], '–': [4345, 4351], 'H194': [4350], 'support': [4352], 'follows': [4359], 'like': [4366], 'ω-currents.': [4370], 'corroborate': [4372], 'finding,': [4374], 'substituted': [4376], 'histidine': [4379], '(D277H)': [4380], 'Zn2+-sensitivity.': [4384], '(Unfortunately,': [4385], 'double': [4387], 'D277H-E335H': [4389], 'express': [4392], 'sufficiently.)': [4393], 'Shaker-iVSD-D277H': [4400], '(V½': [4407], '−99': [4409], 'mV).': [4410], '3g–h).': [4418], 'When': [4419], 'blocking': [4420], '40-times': [4432], '0.15': [4441], '6': [4444], '3i),': [4449], 'Kinetics': [4463], 'development': [4469], 'adopts': [4484], 'protein.': [4497], 'raises': [4499], 'question': [4501], 'kinetics.': [4513], 'analyze': [4515], 'detail,': [4522], '+160': [4544], 'slower': [4553], '4a).': [4557], '(or': [4576], 'deactivated)': [4577], 'slowly': [4579], 'depolarization.': [4581], 'seem': [4588], 'correlate': [4590], '4': [4596], 'Conformational': [4601], 'quenching': [4610], 'Typical': [4620], 'Shaker-iV': [4626]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2989054462', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-13T03:31:57.290226', 'created_date': '2019-11-22'}