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[229, 258, 645, 1002, 1351, 1428, 1623], 'thing': [230], 'happened': [232], 'with': [233, 369, 646, 868, 1142, 1155, 1335, 1414, 1596, 1617, 1756], 'myocardial': [234], 'ischemia': [235], 'was': [236, 644, 667, 1195, 1356, 1777], 'decreased': [237, 1497, 1518], 'contractility,': [238], 'then': [239, 1521, 1621], 'would': [242, 247, 732], 'decrease': [243, 1229, 1472, 1483], 'but': [244, 1426, 1660], 'filling': [245, 267, 2152, 2241], 'rise': [249], 'greatly': [250], 'because': [251, 602, 631, 730, 1125, 1137, 1590, 1661], 'its': [252, 1098, 1757, 2243], 'upstream': [253], '∼10': [259], 'mmHg.': [260], 'What': [261, 1733], 'causes': [262], 'increase': [265, 1233, 1242, 1509, 1523], 'associated': [271, 1413], 'sympathetic': [273], 'tone': [274], 'decreasing': [275, 860], 'vascular': [276, 1760], 'unstressed': [277], 'volume,': [278, 2530], 'same': [285, 801, 914, 1774], 'blood': [286, 848, 873, 890, 901, 950, 982, 1019, 1062, 1133, 1169, 1271, 1534, 1679, 1689, 2442, 2457, 2529], 'volume.': [287, 642], 'This': [288, 1567, 1722], 'also': [289], 'why': [291], 'sympathetolytic': [292], 'agents': [293], 'rapidly': [294], 'improve': [295], 'cardiovascular': [296, 1283, 1366, 2574, 2580, 2620], 'status': [297], '(6).': [298], 'Thus': [299, 718], 'control': [305, 1012, 2414, 2452], 'strongly': [310], 'supported': [311], 'real-life': [313], 'examples': [314], 'pathophysiology': [318], 'disease': [320], 'can': [322, 571, 705, 1052, 1086, 1094, 1427, 1594, 1734], 'used': [324, 1054], 'define': [326], 'appropriate': [327, 870, 1107], 'therapy.REFERENCES1': [328], 'Brengelmann': [329, 1641, 1817, 1959, 2111, 2312], 'GL.': [330, 1818, 1960, 2313], 'Counterpoint:': [331, 1961, 2113, 2314], 'correct.': [351, 430, 1981, 2103, 2133, 2229, 2304, 2334], 'J': [352, 400, 431, 448, 1832, 1861, 1887, 1918, 1947, 1982, 1999, 2104, 2134, 2163, 2197, 2230, 2247, 2305, 2335], 'Appl': [353, 401, 432, 449, 491, 496, 500, 505, 509, 514, 518, 523, 527, 532, 1833, 1862, 1919, 1948, 1983, 2105, 2135, 2231, 2248, 2306, 2336], 'Physiol.': [354, 433, 1984, 2106, 2136, 2232, 2307, 2337], 'In': [355, 434, 966, 1579, 1637, 1985, 2107, 2137, 2233, 2308, 2338], 'press.Google': [356, 435], 'Scholar2': [357], 'AC.': [359], 'Determination': [360], 'equating': [365], 'curves': [368, 442], 'curves.': [372], 'Physiol': [373, 402, 450, 1834, 1863, 1920, 1949, 2032, 2164, 2198, 2249, 2273], 'Rev': [374], '35:': [375], '123–129,': [376], '1955.Link': [377], '|': [378, 380, 406, 454, 456, 486, 488, 1839, 1841, 1868, 1870, 1894, 1896, 1925, 1927, 1954, 1956, 2038, 2040, 2077, 2079, 2169, 2171, 2203, 2205, 2254, 2256, 2278, 2280, 2392, 2428, 2461, 2515, 2562, 2626, 2652, 2677], 'ISI': [379, 455, 487, 1840, 1869, 1895, 1926, 1955, 2039, 2078, 2170, 2204, 2255, 2279], 'Google': [381, 407, 457, 489, 1842, 1871, 1897, 1928, 1957, 1988, 2005, 2041, 2080, 2109, 2139, 2172, 2206, 2235, 2257, 2281, 2310, 2340], 'Scholar3': [382], 'W': [384], 'H.': [387, 2381, 2384], 'Effects': [388], 'epinephrine': [390], 'on': [391, 470, 1537, 1729, 2159, 2535], 'resistive': [392], 'compliant': [394], 'properties': [395, 473, 1751, 2028], 'canine': [398, 446], 'vasculature.': [399], '39:': [403], '272–261,': [404], '1976.ISI': [405], 'Scholar4': [408], 'S.': [410, 2083, 2209, 2284, 2370], 'Point:': [411, 2084, 2210, 2285], 'Scholar5': [436], 'Pinsky': [437], 'MR.': [438], 'Instantaneous': [439], 'intact': [445], 'model.': [447, 2271], '56:': [451], '765–771,': [452], '1984.Link': [453], 'Scholar6': [458], 'Green': [459], 'JF,': [460], 'Jackman': [461], 'AP,': [462], 'Parsons': [464], 'G.': [465, 2112], 'effects': [467, 2581], 'morphine': [469], 'mechanical': [472, 802], 'dog.': [480], 'Circ': [481], 'Res': [482, 2001], '42:': [483, 1890], '474–478,': [484], '1978.Crossref': [485], 'ScholarjapJ': [490], 'PhysiolJournal': [492, 501, 510, 519, 528], 'Applied': [494, 503, 512, 521, 530], 'PhysiologyJ': [495, 504, 513, 522, 531], 'Physiol8750-75871522-1601American': [497, 506, 515, 524, 533], 'Physiological': [498, 507, 516, 525, 534, 2704], 'SocietyjapJ': [499, 508, 517, 526], 'SocietyPoint:Counterpoint': [535], 'CommentsSolbert': [536], 'PermuttThe': [537], 'Johns': [538], 'Hopkins': [539, 564], 'UniversityNovember2006Point:Counterpoint': [540, 552], 'CommentsYuh-Ying': [541], 'Lin': [542, 2007, 2043], 'Wang,': [543], 'Wei-Kung': [545], 'WangDepartment': [546], 'Physics': [548], 'National': [549], 'Taiwan': [550], 'Normal': [551], 'CommentsR.': [553], 'David': [554], 'BakerUTMBNovember2006Point:Counterpoint': [555], 'CommentsCarl': [556], 'RotheIndiana': [557], 'University': [558], 'School': [559], 'MedicineNovember2006Point:Counterpoint': [561], 'CommentsWayne': [562], 'MitznerJohns': [563], 'UniversityNovember2006To': [565], 'viewed': [573], 'elastic': [576, 593, 612, 679, 737, 1251, 1702, 2027], 'compartment': [577], 'analogous': [578], 'lungs.': [581, 1946], 'respiratory': [583, 789], 'physiologist': [584], 'has': [585, 725, 849], 'no': [586, 1591, 1652], 'problem': [587], 'understanding': [589], 'recoil': [594, 609, 680, 773, 1252, 1703, 1914], 'determinant': [598, 685], 'expiratory': [600, 623, 650, 664, 688, 1854, 1916, 1942], 'flow,': [601], 'expiration': [603], 'typically': [604], 'occurs': [605], 'passive': [608, 1482], 'elements': [613], 'lung.': [616], 'It': [617, 643, 911, 1355, 1384], 'may': [618, 809, 1007], 'difficult': [620], 'visualize': [622], 'relations': [627, 652, 1027, 1630], 'under': [628, 653], 'isovolume': [629, 654, 692, 716, 741, 791], 'conditions,': [630], 'air': [632], 'move': [634], 'out': [635, 1186], 'lungs': [638], 'at': [639, 1340, 1352, 1446, 1504, 1712, 2185], 'constant': [640, 1506], 'lung': [641, 1859, 1913], 'construction': [648], 'pressure-flow': [651, 790, 1879], 'conditions': [655, 742], '(not': [656], 'simple': [658, 1372, 1409], 'exercise!;': [659], 'Refs.': [660], '2,': [661], '3)': [662, 1318, 1348], 'limitation': [666], 'understood,': [668], 'resulted': [671], 'appreciation': [674], 'major': [684], 'maximum': [687, 782, 1853], '(4,': [690], '5).The': [691], 'presents': [696], 'opposite': [698], 'dilemma': [699], 'circulatory': [702, 787, 835, 2151, 2157, 2240], 'physiologist.': [703], 'How': [704, 863], 'emptying': [707, 771], 'balloon': [710, 723], 'have': [711, 1286, 1644], 'any': [712, 846, 1143, 1163], 'relevance': [713], 'system?': [717], 'inference': [720], '“the': [722, 1115], 'glaring': [727], 'defect': [728], '…': [729], 'remove': [733], 'from': [735, 799, 842, 1205, 1475, 1944, 2688], 'compartment,': [738], 'prohibiting': [739], 'curve”': [747, 1334, 1339], '(1).': [748, 946], 'conceptual': [750], 'necessity': [751], 'continuous': [753], 'replacement': [754], 'draining': [757], 'obscures': [763], 'simultaneous': [768], 'mechanics': [769], '(elastic': [772], 'return)': [778], 'determines': [780, 1829], 'attainable': [783], 'curves,': [792], 'remarkably': [793], 'similar': [794, 1433], 'each': [796, 1103, 1545], 'other,': [797], 'arise': [798], 'principles': [803], 'clearly': [805], 'reveal': [806], 'how': [807, 1057, 1738], 'become': [810], 'independent': [811], 'activity': [814], 'pump.': [817], 'To': [818], '(5)': [822], 'depicted': [823], 'arterial': [824, 1036, 2060, 2416], 'inflow': [825, 1490, 1541], 'tap': [828], 'bathtub.': [831], 'However,': [832], 'system,': [836], 'there': [837, 1650], 'many': [839], 'bathtubs.': [840], 'Flowing': [841], 'bathtub,': [847], 'travel': [851], 'long': [853], 'journey': [854], 'passing': [856], 'through': [857, 974, 1179], 'tubes': [858], 'cross': [861], 'sections.': [862], 'supply': [865], 'all': [866, 978], 'bathtubs': [867, 979, 1003], 'amount': [871], 'becomes': [874], 'important': [876, 1015], 'task': [877], 'heart.': [880], 'designed': [884, 1358], 'provide': [886, 1360], 'enough': [887, 1009], 'power': [888, 928, 1047], 'transportation': [891], 'efficient': [894], 'way': [895], 'via': [896], 'pulsatile': [897, 1000], 'pumping.Pulsatile': [898], 'pumping': [899, 945], 'makes': [900], 'propagate': [902], 'wave': [905, 958], 'direct': [909], 'flow.': [910, 1917], 'strategy': [915], 'AC': [918], 'transmission': [919], 'line': [920, 1771], 'replace': [922], 'DC': [923], 'current': [924], 'long-distance': [926], 'electric': [927], 'delivery.': [929], 'Pressure': [930, 2019], 'gradients': [931, 1085], 'vasculature': [936, 1755], 'develop': [937], 'hand': [938, 940], 'consequence': [943], 'Movement': [947], 'artery': [952], 'governed': [954], 'equation': [959], "Poiseuille's": [964], 'Law.': [965], 'other': [967, 2155], 'words,': [968], 'left': [969, 1278], 'ventricular': [970, 1512], 'delivered': [973], 'wave,': [976], 'offering': [977], 'sufficient': [981], 'energy': [984], 'source': [985], 'return.': [988, 1470, 1526, 1831], 'Pulse': [989], 'transmitted': [992], 'deeper': [993], 'into': [994, 1097], 'microcirculation': [996], '(2).': [997, 1401], 'Without': [998], 'pump,': [1001], 'near': [1004], 'get': [1008], 'blood.Heart': [1010], 'rate': [1011, 1030, 1059], 'regulation': [1016], 'proper': [1018], 'supply.': [1020], 'Frequency-matching': [1021], 'rules': [1022, 1042, 1051], 'matching': [1026], 'natural': [1033, 2056], 'frequencies': [1034, 2057], 'systems': [1037], 'organs.': [1039], 'Fulfilling': [1040], 'these': [1041, 1050, 1226], 'enhances': [1043], 'efficiency': [1045], 'transportation,': [1048], 'explain': [1056], 'total': [1061, 1449, 1454], 'during': [1065, 1368], 'exercise.To': [1066], 'Hydraulic': [1069], 'customarily': [1072], 'defined': [1073, 1104], 'drop': [1077], 'divided': [1078, 1109, 1803], '(when': [1081], 'gravitational': [1082], 'temperature': [1084], 'ignored).': [1088], 'entire': [1090], 'resistance,': [1092, 1808], '(MAP−RAP)/CO,': [1093], 'split': [1096], 'serial': [1099], 'components': [1100], '(e.g.,': [1101], 'Rprecap),': [1102], 'ΔP': [1108], 'CO.': [1111], "Guyton's": [1112, 1315, 1382, 2640], 'definition': [1113], 'return”': [1119], '[Rvr': [1120], '=': [1121], '(MSFP−RAP)/VR]': [1122], 'unconventional': [1124], 'driving': [1127, 1259, 1303], 'does': [1129], 'exist': [1131, 1632], 'while': [1132, 1168], 'flowing': [1135], 'Rvr': [1138, 1172, 1194, 1203, 1295], 'identified': [1141], 'particular': [1144], 'component': [1146], 'circuit.': [1149], 'MSFP': [1150, 1300], 'should': [1151], 'confused': [1154], 'average': [1157], 'system': [1161, 1167, 1367, 2061], 'flowing.': [1171], 'specifically': [1175], 'system.': [1182], 'himself': [1184], 'pointed': [1185], 'his': [1188, 1331, 1336], 'textbook': [1189], 'about': [1191, 1786], 'one-third': [1192], 'arterioles': [1197], 'small': [1199], 'arteries.The': [1200], 'concept': [1201, 1293, 1306], 'arose': [1204], '“venous': [1206, 1337, 1373], 'curves”': [1208], 'where': [1209], 'increases': [1211], 'RAP': [1213, 1231], 'decreases': [1214], 'below': [1215], 'MSFP.': [1216], 'obvious': [1218], 'explanation': [1219], 'relationship': [1222, 1880, 1911], 'that,': [1224], 'experiments,': [1227], 'VR': [1235, 1262], 'were': [1236], 'both': [1237, 1274], 'caused': [1238], 'experimental': [1241], 'CO,': [1244], 'discussed': [1246, 1736], 'Brengelmann.The': [1248], 'argument': [1249], 'force': [1253, 1260], 'vessel': [1255], 'walls': [1256], 'provides': [1257], '(aka': [1263], 'CO)': [1264], 'specious.': [1266], 'Vessel': [1267], 'wall': [1268], 'tension': [1269], 'maintained': [1275], 'ventricle.As': [1279], 'teacher': [1281], 'physiology,': [1284], 'always': [1287, 1796], 'avoided': [1288], 'fussy': [1290], 'misleading': [1292], 'notion': [1298], 'force.': [1304], 'Neither': [1305, 1402], 'useful.To': [1308], 'A': [1311, 1471, 1819, 2444, 2478], 'careful': [1312], 'reading': [1313], 'papers': [1316], '(2,': [1317], 'related': [1319, 2023], '(Pms)': [1325], 'shows': [1326], 'junction': [1329], '“cardiac': [1332], 'specific': [1342], '(Pra;': [1346], 'Ref.': [1347, 1553], 'valid': [1350], 'equilibrium': [1353], 'conditions.': [1354], 'dynamic': [1362], 'characteristic': [1363], 'disturbances.': [1369], 'resistance”': [1374], '(Rsv)': [1375], 'part': [1380], 'concept.': [1383], '“resistance': [1387], 'return,”': [1390], 'which': [1391, 1421], 'complex': [1394, 1758], 'combination': [1395], 'resistances': [1398], 'compliances': [1400], 'author': [1403], 'seems': [1404, 1642], 'realize': [1406], 'Rsv': [1410], 'must': [1411, 1602], 'peripheral': [1417, 1635, 1707, 1743, 1754, 2156], '(Psv),': [1420], 'currently': [1423], 'measured': [1425], 'assumed': [1430], 'magnitude': [1435], 'Pms.': [1438], 'Pms': [1441, 1458], 'fixed': [1444], 'given': [1448, 1746], 'stressed': [1451, 1487], 'compliance.': [1456], 'changed': [1461], 'arteries': [1477], 'will': [1478, 1514, 1529], 'lead': [1479, 1515, 1530], '(because': [1489, 1499], 'less': [1492], 'than': [1493], 'outflow)': [1494], 'Psv': [1498], 'less)': [1503], 'Pra.': [1507], 'An': [1508, 2266], 'Pra': [1519], 'These': [1527], 'changes': [1528], 'redistributions': [1532], 'based': [1536], 'integral': [1539], 'minus': [1542], 'compartment.': [1546], '(The': [1547], 'principal': [1548], 'mass': [1550], 'balance,': [1551], 'see': [1552], '6).In': [1554], 'retrospect,': [1555], 'wish': [1557], 'had': [1560], 'been': [1561], 'more': [1562], 'explicit': [1563], '(5).To': [1564], 'most': [1570, 1664], 'curious': [1571], 'controversy': [1572, 1587], '(1,': [1573], '2),': [1574], 'seemingly': [1575], 'so': [1576], '20th': [1577], 'Century.': [1578], 'fact,': [1580], 'clear': [1584], 'what': [1585, 1626, 1683], 'really': [1588], 'is,': [1589], 'sane': [1592], 'person': [1593], 'argue': [1595], 'fact': [1598], 'equal': [1603], 'steady': [1608, 1619, 1672], 'state.': [1609], 'So,': [1610], 'if': [1611, 1655], 'we': [1612], 'agree': [1613], 'deal': [1615], 'exclusively': [1616], 'state,': [1620], 'question': [1624], 'hemodynamic': [1629], 'circulation?': [1636], 'regard,': [1639], 'misinterpreted': [1645], 'question.': [1647], 'Of': [1648], 'course': [1649], 'steady-state': [1653, 1789], 'dead,': [1659], 'even': [1662, 1784], 'powerful': [1665], 'generate': [1668], 'blood,': [1669], 'state': [1673], "heart's": [1675], 'ability': [1676], 'limited': [1681], 'comes': [1684], 'back': [1685, 1791], 'it.': [1687], 'returning': [1691], 'driven': [1696], 'difference': [1699], 'input': [1714], 'heart,': [1717], 'i.e.,': [1718], 'atrium.': [1721], 'fact—hardly': [1724], 'something': [1725], 'debated': [1728], 'expensive': [1730], 'journal': [1731], 'pages.': [1732], 'best': [1739], 'circulation,': [1744], 'highly': [1748], 'nonlinear': [1749], 'pressure-volume': [1750], 'parallel': [1759, 2449], 'pathways,': [1761], 'still': [1764], 'entirely': [1766], 'understood.': [1767], 'Nevertheless,': [1768], 'bottom': [1770], 'well': [1778], 'before': [1779], '(or': [1781], 'anyone': [1782], 'else)': [1783], 'thought': [1785], 'it,': [1787], 'determined': [1797], 'gradient': [1802], 'effective': [1806], 'equivalent': [1807], 'properly': [1809], 'designated': [1810], 'return.REFERENCES1.': [1816], 'critical': [1820], 'analysis': [1821, 2358], '94:': [1835], 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