Class I <scp>HDAC</scp> inhibitors enhance <scp>YB</scp> ‐1 acetylation and oxidative stress to block sarcoma metastasis

Name: Work Video:
Duration: 3 min 30 s
Amal M. El-Naggar; Syam Prakash Somasekharan; Yemin Wang; Hongwei Cheng; Gian Luca Negri; Melvin Pan; Xue Q. Wang; Alberto Delaidelli; Bo Rafn; Jordan Cran; Fan Zhang; Haifeng Zhang; Shane Colborne; Martin Gleave; Anna Mandinova; Nancy Kedersha; Christopher S. Hughes; Didier Surdez; Olivier Delattre; Yuzhuo Wang; David G. Huntsman; Gregg B. Morin; Poul H. Sorensen
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3639, 3660, 3707, 3738, 3768, 3786, 3820, 3901, 3945, 3955, 4035], 'more': [71, 91, 118, 135, 156, 183, 212, 252, 279, 306, 323, 363, 382, 400, 420, 439, 468, 487, 506, 524, 566, 587, 634, 689, 709, 736, 753, 774, 801, 830, 870, 897, 924, 941, 981, 1000, 1018, 1038, 1057, 1086, 1105, 1124, 1142, 1184, 1205, 1252], 'papers': [72, 92, 119, 136, 157, 184, 213, 253, 280, 307, 324, 364, 383, 401, 421, 440, 469, 488, 507, 525, 567, 588, 635, 690, 710, 737, 754, 775, 802, 831, 871, 898, 925, 942, 982, 1001, 1019, 1039, 1058, 1087, 1106, 1125, 1143, 1185, 1206, 1253], 'by': [73, 93, 120, 137, 158, 185, 214, 254, 281, 308, 325, 365, 384, 402, 422, 441, 470, 489, 508, 526, 568, 589, 636, 691, 711, 738, 755, 776, 803, 832, 872, 899, 926, 943, 983, 1002, 1020, 1040, 1059, 1088, 1107, 1126, 1144, 1186, 1207, 1254, 1488, 1639, 1770, 2055, 2291, 2319, 2331, 2486, 2673, 2699, 2719, 2815, 2828, 3007, 3360, 3417, 3511, 3818, 4167, 4224, 4245, 4256], 'this': [74, 94, 121, 138, 159, 186, 215, 255, 282, 309, 326, 366, 385, 403, 423, 442, 471, 490, 509, 527, 569, 590, 637, 692, 712, 739, 756, 777, 804, 833, 873, 900, 927, 944, 984, 1003, 1021, 1041, 1060, 1089, 1108, 1127, 1145, 1187, 1208, 1255, 1400, 1485, 1921, 2773, 3467, 3483, 4036, 4216], 'author': [75, 95, 122, 139, 160, 187, 216, 256, 283, 310, 327, 367, 386, 404, 424, 443, 472, 491, 510, 528, 570, 591, 638, 693, 713, 740, 757, 778, 805, 834, 874, 901, 928, 945, 985, 1004, 1022, 1042, 1061, 1090, 1109, 1128, 1146, 1188, 1209, 1256, 1439], 'Syam': [76, 79, 694, 697, 1262], 'Prakash': [77, 80, 695, 698, 1263], 'Somasekharan': [78, 81, 696, 699], 'orcid.org/0000-0002-9006-8206': [82, 700], 'Vancouver': [83, 127, 315, 392, 516, 701, 745, 933, 1010, 1134], 'Prostate': [84, 128, 316, 393, 517, 702, 746, 934, 1011, 1135, 1357], 'Centre,': [85, 129, 150, 317, 376, 394, 518, 581, 703, 747, 768, 935, 994, 1012, 1136, 1199, 1358, 1366], 'Yemin': [96, 98, 714, 716, 1265], 'Wang': [97, 99, 190, 193, 512, 514, 715, 717, 808, 811, 1130, 1132], 'Hongwei': [123, 125, 741, 743, 1267], 'Cheng': [124, 126, 742, 744], 'Gian': [140, 143, 758, 761, 1269], 'Luca': [141, 144, 759, 762, 1270], 'Negri': [142, 145, 760, 763], 'Michael': [146, 372, 577, 764, 990, 1195], 'Smith': [147, 373, 578, 765, 991, 1196, 1363], 'Genome': [148, 374, 579, 766, 992, 1197, 1364], 'Sciences': [149, 375, 580, 767, 993, 1198, 1365], 'Melvin': [161, 163, 779, 781, 1272], 'Pan': [162, 164, 780, 782], 'Xue': [188, 191, 806, 809, 1274], 'Qi': [189, 192, 807, 810, 1275], 'Alberto': [217, 219, 835, 837, 1277], 'Delaidelli': [218, 220, 836, 838], 'Bo': [257, 259, 875, 877, 1279], 'Rafn': [258, 260, 876, 878], 'Jordan': [284, 286, 902, 904, 1281], 'Cran': [285, 287, 903, 905], 'Fan': [311, 313, 929, 931, 1283], 'Zhang': [312, 314, 329, 331, 930, 932, 947, 949], 'Haifeng': [328, 330, 946, 948, 1285], 'Shane': [368, 370, 986, 988, 1287], 'Colborne': [369, 371, 987, 989], 'Martin': [387, 389, 1005, 1007, 1289], 'Gleave': [388, 390, 1006, 1008], 'orcid.org/0000-0003-4235-0167': [391, 1009], 'Anna': [405, 407, 1023, 1025, 1291], 'Mandinova': [406, 408, 1024, 1026], 'Brigham': [409, 1027], "Women's": [411, 1029, 1372], 'Hospital,': [412, 431, 1030, 1049, 1373, 1381], 'Harvard': [413, 432, 1031, 1050, 1374, 1382], 'Boston,': [415, 434, 1033, 1052, 1376, 1384], 'MA,': [416, 435, 1034, 1053, 1377, 1385], 'USA': [417, 436, 1035, 1054, 1378, 1386], 'Nancy': [425, 427, 1043, 1045, 1293], 'Kedersha': [426, 428, 1044, 1046], 'Massachusetts': [429, 1047], 'General': [430, 1048, 1380], 'Christopher': [444, 447, 1062, 1065, 1295], 'S': [445, 448, 1063, 1066, 1296], 'Hughes': [446, 449, 1064, 1067], 'Didier': [473, 475, 1091, 1093, 1298], 'Surdez': [474, 476, 1092, 1094], 'Centre': [477, 496, 1095, 1114], 'de': [478, 480, 497, 499, 1096, 1098, 1115, 1117, 1388, 1390], 'recherche': [479, 498, 1097, 1116, 1389], "l'Institut": [481, 500, 1099, 1118, 1391], 'Curie,': [482, 501, 1100, 1119, 1392], 'Paris,': [483, 502, 1101, 1120, 1393], 'France': [484, 503, 1102, 1121, 1394], 'Olivier': [492, 494, 1110, 1112, 1300], 'Delattre': [493, 495, 1111, 1113], 'Yuzhuo': [511, 513, 1129, 1131, 1302], 'orcid.org/0000-0002-9749-8591': [515, 1133], 'David': [529, 532, 1147, 1150, 1304], 'G': [530, 533, 1148, 1151, 1305], 'Huntsman': [531, 534, 1149, 1152], 'Gregg': [571, 574, 1189, 1192, 1307], 'B': [572, 575, 1190, 1193, 1308], 'Morin': [573, 576, 1191, 1194], 'Poul': [592, 597, 1210, 1215, 1311], 'H': [593, 598, 1211, 1216, 1312], 'Sorensen': [594, 599, 1212, 1217, 1313], 'Corresponding': [595, 1213], 'Author': [596, 1214, 1257], '[email': [600, 1218, 1410], 'protected]': [601, 1219, 1411], 'orcid.org/0000-0001-7447-2199': [602, 1220], 'Information': [1258], 'El-Naggar1,2,3,': [1261], 'Somasekharan4,‡,': [1264], 'Wang2,‡,': [1266], 'Cheng4,‡,': [1268], 'Negri5,‡,': [1271], 'Pan2,': [1273], 'Wang2,': [1276], 'Delaidelli1,2,': [1278], 'Rafn2,': [1280], 'Cran2,': [1282], 'Zhang4,': [1284], 'Zhang1,2,': [1286], 'Colborne5,': [1288], 'Gleave4,': [1290], 'Mandinova6,': [1292], 'Kedersha7,': [1294], 'Hughes2,': [1297], 'Surdez8,': [1299], 'Delattre8,': [1301], 'Wang4,': [1303], 'Huntsman1,2,': [1306], 'Morin5': [1309], '*,1,2': [1314], '1Department': [1315], '2Department': [1328], '3Department': [1344], '4Vancouver': [1356], '5Michael': [1362], '6Brigham': [1370], '7Massachusetts': [1379], '8Centre': [1387], '‡These': [1395], 'authors': [1396], 'contributed': [1397], 'equally': [1398], 'work': [1401, 1986, 2105], '*Corresponding': [1402], 'author.': [1403], 'Tel:': [1404], '+1': [1405], '604': [1406], '675': [1407], '8202;': [1408], 'E-mail:': [1409], 'EMBO': [1412], 'Reports': [1413], '(2019)20:e48375https://doi.org/10.15252/embr.201948375': [1414], 'PDFDownload': [1415], 'PDF': [1416], 'article': [1418], 'text': [1419], 'main': [1421], 'figures.': [1422], 'Peer': [1423], 'ReviewDownload': [1424], 'a': [1425, 1604, 1706, 1857, 2188, 2406, 2608, 2675, 2708, 2783, 2816, 2820, 2880, 2901, 2910, 2928, 3014, 3114, 3173, 3200, 3708, 3829, 3877, 3892, 3898, 4063, 4138, 4191], 'summary': [1426], 'editorial': [1429, 1433], 'decision': [1430, 1434], 'including': [1432, 1631, 1850, 1936, 1974, 1983, 2564, 2607], 'letters,': [1435], 'reviewer': [1436], 'comments': [1437], 'responses': [1440, 2102, 2215], 'feedback.': [1442], 'ToolsAdd': [1443], 'favoritesDownload': [1445], 'CitationsTrack': [1446], 'CitationsPermissions': [1447], 'ShareFacebookTwitterLinked': [1448], 'InMendeleyWechatReddit': [1449], 'Figures': [1450], 'Info': [1452], 'Abstract': [1453], 'Outcomes': [1454], 'metastatic': [1456, 1590, 1659, 1719, 1868, 1902, 1977, 2203, 2476, 2508], 'Ewing': [1457, 1851], 'osteosarcoma': [1460, 1855], 'are': [1461, 1780, 1928, 2421, 2762, 2775, 2946, 2975, 3117, 3307, 3463, 3607, 3648, 3726, 3774, 3999, 4032, 4294], 'dismal': [1462], 'have': [1464, 2446, 2618], 'not': [1465, 2888], 'changed': [1466], 'decades.': [1468], 'Oxidative': [1469, 2643], 'attenuates': [1471], 'melanoma': [1472, 1475, 1763, 2646], 'metastasis,': [1473, 2314], 'cells': [1476, 1712, 1738, 1749, 1766, 1785, 1953, 2033, 2089, 2117, 2152, 2572, 2642, 2667, 2801, 2896, 2953, 2961, 3031, 3083, 3151, 3186, 3214, 3219, 3276, 3347, 3391, 3495, 3536, 3576, 3631, 3672, 3750, 3805, 3839, 3927, 3986, 4079, 4091, 4113, 4145, 4178, 4298], 'must': [1477], 'reduce': [1478, 2671], 'metastasize.': [1482], 'We': [1483, 1904, 2386, 2483, 2683, 2748, 2781, 4042, 4174, 4281, 4317], 'explored': [1484], 'in': [1486, 1510, 1582, 1598, 1690, 1765, 1783, 1791, 1880, 1895, 1915, 1997, 2084, 2140, 2159, 2210, 2253, 2278, 2354, 2390, 2465, 2478, 2510, 2530, 2551, 2570, 2581, 2626, 2640, 2722, 2744, 2772, 2923, 2951, 2959, 2994, 3028, 3080, 3131, 3149, 3184, 3212, 3222, 3262, 3331, 3383, 3441, 3490, 3572, 3627, 3668, 3674, 3746, 3752, 3794, 3807, 3810, 3859, 3921, 3976, 4050, 4077, 4089, 4099, 4104, 4144, 4150, 4160, 4268, 4289, 4297, 4304, 4327], 'sarcomas': [1487, 1849], 'screening': [1489], 'sensitizers,': [1493], 'which': [1494, 2043, 2169, 2933, 4116, 4164, 4221, 4240, 4252], 'identified': [1495], 'class': [1497, 2558, 2774, 2850, 2984], 'inhibitor': [1500, 2987], 'MS-275': [1501, 1514, 1545, 1577, 1608, 1632, 1679, 2565, 2584, 2634, 2854, 2874, 2922, 2926, 2988, 3038, 3085, 3158, 3180, 3229, 3283, 3397, 3499, 3539, 3583, 3634, 3761, 3814, 3841, 3929, 3988, 4046, 4066, 4095, 4125, 4236, 4261, 4273, 4285, 4321], 'as': [1502, 1563, 1565, 2069, 2298, 2567, 2635, 2662, 3013, 3113, 3119, 3172, 3194, 3199, 3309, 3372, 3430, 3509, 3609, 3650, 3716, 3728, 3776, 3815, 3823, 3828, 4062, 4179, 4213], 'enhancing': [1503, 1640, 2656], 'vulnerability': [1504], 'reactive': [1506, 1758], 'oxygen': [1507, 1759], 'species': [1508, 1760], '(ROS)': [1509, 1761], 'cells.': [1512, 2498, 4053, 4272, 4291], 'Mechanistically,': [1513, 2583], 'inhibits': [1515, 2044], 'deacetylation,': [1517], 'decreasing': [1518], 'its': [1519, 1623, 1641, 1645, 1810, 1820, 2240, 2339], 'binding': [1520, 1557, 1636, 2131, 2218, 2333, 2359, 2402, 2593], '5′-UTRs': [1522], 'NFE2L2': [1524, 1532, 3358, 3363], 'encoding': [1525, 1842, 2019, 2397, 2613], 'antioxidant': [1527, 1774, 1798, 2678, 3138, 3207, 3764, 4313], 'factor': [1528, 1836, 1839, 2206, 4315], 'NRF2,': [1529, 1593], 'thereby': [1530], 'reducing': [1531], 'translation': [1533, 1673, 1999, 2008, 2046, 2065, 2079, 2141, 2184, 2193, 2340, 2431, 2461], 'synthesis': [1535, 1597, 1665, 2002, 2344, 4277], 'NRF2': [1537, 1664, 1801, 1805, 1843, 2156, 3182, 3914, 3936, 3970, 4276, 4311, 4325], 'increase': [1539, 2342, 2382, 2714, 4071, 4324], 'cellular': [1540, 1651, 2136], 'ROS.': [1541], 'By': [1542], 'global': [1543, 2045], 'acetylomics,': [1544], 'promotes': [1546, 2316], 'rapid': [1547, 4208], 'RNA-binding': [1552, 2225], 'protein': [1553, 1637, 1811, 1822, 2001, 2041, 2219, 2226, 2249, 2399, 2403, 2412, 3066, 3558, 3915, 3971], 'at': [1554, 2056, 2811, 2879, 3144, 3501, 3941, 3990], 'lysine-81,': [1555], 'blocking': [1556, 2574], 'translational': [1559, 1616, 1677, 2108, 2173, 2211, 2368, 2372, 2602], 'activation': [1560, 1794, 2373], 'NFE2L2,': [1562, 2612], 'well': [1564], 'known': [1566, 2207], 'mRNA': [1568, 1648, 1998, 2129, 2143, 2396], 'targets,': [1569], 'HIF1A,': [1570], 'granule': [1574, 2409], 'nucleator,': [1575], 'G3BP1.': [1576], 'dramatically': [1578, 4217], 'reduces': [1579, 1644, 1672], 'vivo,': [1583], 'but': [1584, 1883, 2062, 2727, 4148], 'an': [1585, 1701, 1772, 2224, 2500, 2636, 2687, 3885], 'MS-275-resistant': [1586], 'YB-1K81-to-alanine': [1587], 'mutant': [1588], 'restores': [1589], 'capacity': [1591, 1978, 2477, 2576], 'HIF1α,': [1594], 'G3BP1': [1596, 2460, 2468], 'MS-275-treated': [1599], 'mice.': [1600], 'These': [1601, 2615], 'studies': [1602, 2445, 2555, 2616], 'describe': [1603], 'novel': [1605], 'function': [1606, 2209], 'through': [1609, 1793, 1831, 1994, 2047, 2239, 4307], 'enhanced': [1610, 2026, 2839, 4330], 'acetylation,': [1612], 'thus': [1613], 'inhibiting': [1614], 'control': [1617, 2212, 3314], 'key': [1619, 2073, 2081, 2407], 'cytoprotective': [1620, 2082, 2365], 'factors': [1621, 2083, 2274, 2296], 'pro-metastatic': [1624, 2276, 2350], 'activity.': [1625], 'Synopsis': [1626], '1': [1628, 2220, 2404, 2812, 2881, 2943, 2982, 3001, 3052, 3102, 3167, 3192, 3246, 3297, 3353, 3409, 3473, 3544, 3597, 3851], 'inhibit': [1633], 'RNA': [1635, 3334, 3340, 3388], 'acetylation.': [1642], 'This': [1643, 2248], 'affinity': [1646], 'targets': [1649, 2935], 'under': [1650, 1666, 1813, 2006, 2345, 2418, 2440, 4001, 4278], 'stress,': [1652, 1815, 1935, 1938, 1943, 2420, 2442], 'decreases': [1654], 'tumor': [1655, 1711, 1737, 1784, 1952, 2032, 2088, 2116, 2165, 2497, 2666], 'cell': [1656, 1685, 2075, 2383, 2441, 2532, 2745, 2890, 3507, 4185], 'fitness': [1657, 2495], 'capacity.': [1660], 'translationally': [1662, 2269, 2285, 2320], 'activates': [1663, 2270, 2395], 'stress.': [1668, 2122], 'MS-275-mediated': [1669], 'multiple': [1675, 1932], 'targets.': [1678], 'blocks': [1680, 2475, 2645, 4275], 'childhood': [1683, 1847, 2627], 'lines': [1686], 'PDX': [1688], 'tumors': [1689], 'pre-clinical': [1691], 'models.': [1692], 'Introduction': [1693], 'Tumor': [1694], 'is': [1696, 1729, 1806, 1863, 1872, 1948, 1966, 2012, 2025, 2110, 2170, 2216, 2223, 2250, 2260, 2457, 2927], 'widely': [1697], 'held': [1698], 'be': [1700, 1924, 2660, 2691, 4243], 'inefficient': [1702], 'process,': [1703], 'with': [1704, 1732, 1901, 2063, 2153, 2263, 2275, 2534, 2597, 2731, 2807, 2819, 2832, 2909, 2981, 2996, 3037, 3047, 3155, 3188, 3242, 3267, 3282, 3292, 3396, 3405, 3522, 3582, 3592, 3680, 3712, 3897, 3934, 3953, 4101, 4152, 4235], 'only': [1705, 2728, 2873, 4085, 4149, 4157], 'tiny': [1707], 'fraction': [1708], 'primary': [1710], 'surviving': [1713], 'many': [1715, 2770], 'steps': [1716], 'form': [1722, 2438], 'distant': [1723], 'metastases': [1724], '1,': [1725], '2.': [1726], 'Metastatic': [1727], 'dissemination': [1728], 'highly': [1730, 2241, 2251], 'stressful,': [1731], 'each': [1733, 3026, 3078, 3129, 3260, 3317, 3329, 3381, 3439, 3570, 3625, 3666, 3744, 3792], 'step': [1734, 4194], 'continuously': [1735], 'subjecting': [1736], 'heterogeneous': [1740], 'microenvironments': [1741, 2095], 'diverse': [1743, 2271, 2489], 'stresses': [1744], 'potentially': [1746, 1949], 'cull': [1747], 'pre-metastatic': [1748], '3.': [1750], 'For': [1751, 1845, 2004, 2123], 'example,': [1752, 2005, 2124], 'accumulation': [1756, 2526, 2658, 4264], 'prevents': [1762], 'unable': [1767], 'adapt': [1769, 1956, 2669], 'mounting': [1771], 'efficient': [1773], 'response': [1775, 2273, 2680, 3208, 4328], '4,': [1776, 2648], '5.': [1777], 'ROS': [1778, 2525, 2569, 2657, 2672, 2701, 2742, 2957, 3057, 3061, 3302, 3488, 3549, 3553, 3602, 3640, 3718, 3769, 4064, 4072, 4088, 4098, 4200, 4219, 4263, 4287, 4292, 4331], 'levels': [1779, 3058, 3062, 3303, 3550, 3554, 3603, 3641, 3719, 3770, 3972, 4073, 4293], 'tightly': [1781, 4295], 'controlled': [1782, 4296], 'prevent': [1787, 1865, 4300], 'ROS-induced': [1788, 4301], 'toxicity': [1789, 2877, 4302], '6,': [1790, 4303], 'master': [1797, 4312], 'transcription': [1799, 1833, 2295, 4314], 'factor,': [1800], '7.': [1802, 4316], 'Activation': [1803], 'largely': [1807, 2013], 'attributed': [1808], 'stabilization': [1812], 'due': [1816, 2175], 'dissociation': [1818], 'from': [1819, 2971, 3345, 3389, 3837, 4187], 'repressor': [1821], 'Keap1': [1823], 'when': [1824, 2729], 'latter': [1826], 'becomes': [1827], 'oxidized': [1828, 4133], '8,': [1829], 'or': [1830, 1866, 2993, 3036, 3046, 3096, 3156, 3225, 3240, 3270, 3281, 3291, 3395, 3581, 3591, 3683, 3699, 3755, 4226], 'increased': [1832, 2120, 2494, 4087, 4097, 4158, 4218, 4238, 4250], 'nuclear': [1835], 'erythroid': [1837], '2-related': [1838], '2': [1840, 3436], '(NFE2L2)': [1841], '9.': [1844], 'high-risk': [1846, 2723], 'bone': [1848, 2628, 4270], '(EwS)': [1853], '(OS),': [1856], 'major': [1858, 2128], 'roadblock': [1859], 'improving': [1861, 1896], 'outcomes': [1862], 'treat': [1867], 'disease.': [1869, 1903, 2204], 'Indeed,': [1870], 'single': [1874], 'most': [1875], 'powerful': [1876], 'predictor': [1877], 'outcome': [1879, 2265], 'these': [1881, 2453, 2488, 2552, 2871], 'diseases,': [1882], 'essentially': [1884], 'no': [1885, 2876], 'progress': [1886], 'has': [1887], 'been': [1888], 'made': [1889], 'past': [1892], 'several': [1893], 'decades': [1894], 'survival': [1897, 2029, 2076, 2114], 'patients': [1900], 'therefore': [1905, 2548, 2617, 2684, 4318], 'investigated': [1906, 4283], 'how': [1907, 2192, 4284], 'adaptation': [1908, 1960, 1991], 'might': [1912, 2659, 2690], 'facilitate': [1913], 'EwS': [1916, 2255, 2479, 2511, 2757, 4112], 'OS,': [1918, 2257, 2513], 'if': [1920], 'could': [1923, 4242], 'targeted': [1925], 'therapeutically.': [1926], 'Tumors': [1927], 'continually': [1929], 'exposed': [1930, 2118, 3091], 'forms': [1933, 4134], 'hypoxia,': [1939, 2007], 'nutrient': [1940], 'depletion,': [1941], 'genotoxic': [1942], 'cytotoxic': [1945], 'therapy.': [1946], 'Each': [1947], 'lethal': [1950], 'unless': [1951], 'can': [1954, 2668], 'acutely': [1955], 'it.': [1958], 'Stress': [1959], 'via': [1961], 'mutationally': [1962], 'driven': [1963], 'clonal': [1964], 'selection': [1965], 'postulated': [1967], 'underlie': [1969], 'acquisition': [1970, 3902], 'aggressive': [1972], 'phenotypes': [1973], 'chemoresistance': [1975], '10.': [1979], 'However,': [1980, 2665, 4094], 'accumulating': [1981], 'evidence,': [1982], 'our': [1984], 'own': [1985], '11,': [1987], 'suggests': [1988, 2106], 'that': [1989, 2016, 2107, 2144, 2228, 2389, 2437, 2485, 2523, 2538, 2654, 2686, 2713, 2755, 4045, 4320], 'also': [1992, 2387, 4254], 'occurs': [1993], 'acute': [1995], 'changes': [1996], '12.': [2003], 'pro-growth': [2010], 'mRNAs': [2011, 2018, 2237, 2436], 'inhibited,': [2014], 'while': [2015, 4335], 'HIF1α': [2020, 2343], 'other': [2022], 'proteins': [2024, 2067], 'promote': [2028], 'hypoxic': [2031], '13.': [2034], 'Similarly,': [2035], 'ER': [2036], 'initiates': [2038], 'unfolded': [2040], 'response,': [2042], 'phosphorylation': [2048], 'ternary': [2051], 'complex': [2052], 'component,': [2053], 'eIF2α,': [2054], 'least': [2057], 'four': [2058], 'activated': [2060, 2969], 'kinases,': [2061], 'selective': [2064], 'such': [2068, 2085, 2297, 2539, 2694], 'BIP': [2070], 'chaperones': [2072], '14.': [2077], 'Selective': [2078], 'settings': [2086], 'allows': [2087], 'rapidly': [2091, 2439], 'respond': [2092], 'changing': [2094], 'without': [2096, 3034, 3044, 3157, 3279, 3289, 3393, 3579, 3589], 'need': [2098], 'protracted': [2100], 'transcriptional': [2101], '15.': [2103], 'Recent': [2104], 'reprogramming': [2109], 'particularly': [2111], 'important': [2112, 2619], 'haploinsufficiency': [2125], 'cap': [2130], 'protein,': [2132], 'eIF4E,': [2133], 'significantly': [2134, 2838, 4070, 4126], 'impedes': [2135], 'transformation': [2137], 'deficiency': [2139, 2469], 'mitigate': [2145], '16.': [2148], 'Moreover,': [2149, 4124], 'pancreatic': [2150], 'carcinoma': [2151, 2313], 'loss': [2154, 2472], 'show': [2157], 'defects': [2158], 'redox': [2160, 2195, 3107], 'homeostasis': [2161, 2196, 4288], 'markedly': [2163, 4096], 'diminished': [2164], 'initiation': [2166, 2432], 'maintenance,': [2168], 'linked': [2171, 2764], 'inhibition': [2174], 'oxidation': [2177], 'different': [2180], 'members': [2181], 'machinery': [2185], '17.': [2186], 'Therefore,': [2187, 4260], 'greater': [2189, 2911], 'understanding': [2190], 'regulates': [2194, 4286], 'may': [2197], 'uncover': [2198, 2449, 2503], 'new': [2199, 2504, 2609, 3696], 'strategies': [2200, 2505], 'targeting': [2202, 2623], 'One': [2205], 'stress-adaptive': [2214, 2605], 'Y-box': [2217], '(YB-1/YBX1).': [2221], '(RBP)': [2227], 'binds': [2229, 2393], '5′-': [2231], '3′-untranslated': [2233], 'regions': [2234], '(UTRs)': [2235], 'mainly': [2238, 2416], 'conserved': [2242], 'cold': [2243], 'shock': [2244], 'domain': [2245], '(CSD)': [2246], '18.': [2247], 'expressed': [2252, 3118, 3371, 3429], 'both': [2254, 2756], 'where': [2258], 'it': [2259], 'strongly': [2261, 2763], 'associated': [2262], 'poor': [2264], '19,': [2266], '20.': [2267], 'activities': [2277], 'human': [2279, 2724, 2779], 'malignancies.': [2280], 'In': [2281, 2311, 2326, 2499], 'breast': [2282, 2305], 'cancers,': [2283], 'controls': [2286], 'epithelial-to-mesenchymal': [2288], 'transition': [2289], '(EMT)': [2290], 'activating': [2292, 2674], 'expression': [2293, 3183, 3359, 4326], 'SNAIL,': [2299], 'TWIST,': [2300], 'ZEB2': [2302], 'drive': [2304], 'cancer': [2306, 4184], 'EMT': [2307], '21.': [2310], 'colorectal': [2312], 'liver': [2317], 'regulating': [2321], 'IGF1': [2323], 'receptor': [2324], '22.': [2325], 'sarcomas,': [2327, 2391, 2466], 'facilitates': [2329], 'directly': [2332], 'HIF1A': [2335], '5′-UTR': [2336], 'activate': [2338], 'hypoxia': [2346], '19.': [2347], 'Other': [2348], 'potential': [2349], 'functions': [2351], 'include': [2352], 'roles': [2353], 'stabilizing': [2355], 'oncogenic': [2356], 'transcripts': [2357], '23,': [2358], 'tRNA': [2361], 'fragments': [2362], 'mediate': [2364], 'stress-induced': [2367], 'repression': [2369], '24,': [2370], 'Rho': [2376], 'GTPAse-dependent': [2377], 'ROCK1': [2378], 'ser/thr': [2379], 'kinase': [2380], 'motility': [2384], '25.': [2385], 'found': [2388], 'Ras-GTPase-activating': [2398], '(SH3': [2400], 'domain)': [2401], '(G3BP1),': [2405], '(SG)': [2410], 'nucleating': [2411], '26,': [2413], '27.': [2414], 'SGs,': [2415], 'studied': [2417], 'cytoplasmic': [2422, 3867], 'aggregates': [2423], 'composed': [2424], 'RBPs,': [2426], '40S': [2428], 'ribosome,': [2429], 'stalled': [2430], 'complexes,': [2433], 'silenced': [2435], 'recent': [2444], 'begun': [2447], 'composition': [2451], 'structures': [2454], '28-31.': [2455], 'essential': [2458], 'SG': [2463], 'formation': [2464, 4209], 'leading': [2470, 2650], 'SGs': [2474], 'OS': [2481, 2760, 2800], '32.': [2482], 'hypothesize': [2484], 'mediating': [2487], 'responses,': [2491, 2696], 'confers': [2493], 'effort': [2501], 'target': [2507, 2595], 'disease': [2509], 'we': [2514, 2706, 2919], 'performed': [2515, 3027, 3079, 3130, 3261, 3330, 3382, 3440, 3571, 3626, 3667, 3745, 3793], 'small': [2516], 'molecule': [2517], 'screens': [2518, 2632, 2955], 'search': [2520], 'agents': [2522, 2655], 'induce': [2524], 'lines,': [2533], 'rationale': [2536], 'being': [2537], 'compounds': [2540, 2712, 2771, 2788, 2837], 'should': [2541], 'further': [2542, 3403, 3709, 4237], 'decrease': [2543], 'efficiency': [2545], 'of,': [2546], 'limit,': [2549], 'diseases.': [2553], 'Our': [2554], 'unexpectedly': [2556], 'highlight': [2557], 'histone': [2560, 2792], 'deacetylase': [2561], '(HDAC)': [2562], 'inhibitors,': [2563, 2853, 2863], '(Entinostat),': [2566, 2855], 'increasing': [2568, 2700], 'their': [2575], 'invasion': [2578], 'vivo.': [2582], 'induces': [2585], 'within': [2587], 'CSD': [2590], 'mRNAs,': [2596, 2606], 'widespread': [2598], 'effects': [2599, 3135, 3178], 'on': [2600, 2751, 2921, 3141, 3181, 3505, 3800, 3853, 3863, 3871, 3974], 'regulation': [2603], 'target,': [2611], 'NRF2.': [2614], 'implications': [2620], 'therapeutic': [2622], 'sarcomas.': [2629], 'Results': [2630], 'Cell-based': [2631, 2954], 'identify': [2633], 'sensitizer': [2639], '5,': [2649], 'notion': [2653], 'effective': [2661], 'anti-metastatic': [2663], 'therapeutics.': [2664], 'variety': [2676], 'pathways': [2681], '33.': [2682], 'reasoned': [2685], 'alternative': [2688], 'approach': [2689], 'adaptive': [2695], 'rather': [2697], 'than': [2698, 2913], 'itself.': [2702], 'To': [2703], 'evaluate': [2704], 'this,': [2705], 'established': [2707], 'cell-based': [2709], 'screen': [2710], 'sensitivity': [2715], 'inducing': [2720, 3937], 'apoptosis': [2721, 4159], 'cells,': [2726, 4163], 'combined': [2730], 'sublethal': [2732, 2821], 'doses': [2733, 3504], 'sodium': [2735], 'arsenite': [2736], '(NaAsO2),': [2737], 'commonly': [2738], 'used': [2739, 2782, 3012, 3171, 3198, 3827, 3962], 'stimulate': [2741], 'production': [2743, 3489], 'culture': [2746, 3492], '34.': [2747], 'initially': [2749], 'focused': [2750, 2920], 'epigenetic': [2752, 2766], 'regulators,': [2753], 'given': [2754], '35': [2758], '36': [2761], 'deregulation,': [2767], 'because': [2769], 'already': [2776], 'approved': [2777], 'use.': [2780], 'commercial': [2784], 'library': [2785, 2810], '92': [2787], 'directed': [2789], 'against': [2790, 3368, 3426], 'HDACs,': [2791], 'acetyltransferases,': [2793], 'methyltransferases,': [2794], 'demethylases,': [2795], 'acetyl-lysine': [2797], 'readers.': [2798], 'U2OS': [2799, 2960, 3005, 3030, 3082, 3150, 3185, 3213, 3264, 3346, 3390, 3506, 3535, 3630, 3671, 3749, 3804, 3838, 3922, 3977, 4078, 4105, 4162], 'were': [2802, 2849, 2861, 2897, 3032, 3063, 3090, 3277, 3343, 3366, 3411, 3424, 3546, 3555, 3577, 3637, 3678, 3720, 3766, 3869, 3889, 3932], 'pre-treated': [2803, 3933], '24': [2805, 2990, 3041, 3088, 3161, 3232, 3286, 3400, 3586, 3844], 'h': [2806, 2991, 3002, 3711], 'above': [2809, 2834], 'μM,': [2813, 3040, 3051, 3087, 3101, 3160, 3166, 3191, 3231, 3245, 3285, 3296, 3352, 3399, 3408, 3543, 3585, 3596, 3843, 3850], 'followed': [2814, 2827, 3416], '1-h': [2817, 2903], 'treatment': [2818, 2831, 2980, 3154, 3500, 3715, 3989, 4322], 'dose': [2822], '100': [2824, 2906, 2997], 'μM': [2825, 2882, 2907, 2983, 2998, 3943], 'NaAsO2,': [2826, 2908], 'additional': [2829], '12-h': [2830], 'library.': [2835], 'Nine': [2836], 'NaAsO2-induced': [2840], 'death': [2841], '(Fig': [2842, 2884, 2892, 2916, 4092, 4114, 4122, 4154, 4229, 4247, 4258], '1A': [2843], 'Appendix': [2845], 'Table': [2846, 2868], 'S1);': [2847], 'three': [2848, 2972], 'Quisinostat,': [2856], 'Romidepsin,': [2858], 'two': [2860, 3378, 4007], 'pan-HDAC': [2862], 'Panobinostat,': [2864], 'SAHA': [2866], '(Appendix': [2867], 'S1).': [2869], 'Of': [2870], 'compounds,': [2872], 'had': [2875], 'alone': [2878, 2915, 2992, 3682, 4067], 'concentration': [2883], '1B)': [2885], 'did': [2887], 'affect': [2889], 'proliferation': [2891, 3508], 'EV1A);': [2893], 'however,': [2894, 4334], 'MS-275-pre-treated': [2895], 'potently': [2898], 'killed': [2899], 'after': [2900, 3917, 3995], 'subsequent': [2902, 2924], 'exposure': [2904], 'effect': [2912], 'NaAsO2': [2914, 2999, 3048, 3097, 3164, 3189, 3243, 3293, 3350, 3406, 3541, 3593, 3636, 3848, 4102, 4153], '1B),': [2917], 'so': [2918], 'studies.': [2925], 'synthetic': [2929], 'benzamide': [2930], 'derivative': [2931, 4056], 'HDACi,': [2932], 'preferentially': [2934], 'HDAC1': [2936], 'HDAC3': [2938], '37.': [2939], 'Figure': [2940, 3472, 3485], '1.': [2941], 'potent': [2947], 'sensitizers': [2950, 2958], '(see': [2962], 'Materials': [2963], 'Methods).': [2965], 'Average': [2966], 'z-scores': [2967], 'caspase-3/7': [2970], 'independent': [2973, 3024, 3076, 3127, 3258, 3327, 3379, 3437, 3532, 3568, 3623, 3664, 3742, 3790, 4008], 'experiments': [2974, 4009], 'plotted.': [2976], 'Time': [2977], 'course': [2978], 'combination': [2995, 4100, 4151], 'assess': [3004], 'viability': [3006, 3802], 'NucView-488': [3008], 'fluorescence.': [3009], 'DMSO': [3010], 'was': [3011, 3170, 3197, 3265, 3826, 3950, 3961, 4117, 4165, 4222, 4253], 'vehicle': [3015, 3093, 3313, 3613, 3654, 3681, 3732, 3780, 4076], 'control.': [3016, 3175, 3202, 3614, 3655, 3733, 3781, 3831], 'Error': [3017, 3068, 3250, 3319, 3560, 3615, 3656, 3734, 3782], 'bars': [3018, 3069, 3251, 3320, 3561, 3616, 3657, 3735, 3783], 'indicate': [3019, 3070, 3252, 3321, 3562, 3617, 3658, 3736, 3784], 'SEM': [3020, 3071, 3253, 3322, 3376, 3434, 3563, 3618, 3659, 3737, 3785], '(n': [3021], '=': [3022, 3074, 3125, 3256, 3325, 3459, 3525, 3530, 3566, 3621, 3662, 3740, 3788, 4028], '3': [3023, 3075, 3126, 3257, 3326, 3531, 3567, 3622, 3663, 3741, 3789], 'experiments,': [3025, 3077, 3128, 3259, 3328, 3380, 3438, 3569], 'triplicate).': [3029], 'treated': [3033, 3187, 3241, 3278, 3348, 3392, 3404, 3537, 3578, 3632, 3679], '(vehicle)': [3035, 3227, 3280, 3394, 3580], '(1': [3039, 3086, 3159, 3230, 3284, 3398, 3584, 3842], 'h),': [3042, 3287, 3354, 3587, 3845], '(−NaAsO2)': [3045, 3290, 3315, 3590], '(+NaAsO2)': [3049, 3294, 3594], '(500': [3050, 3190, 3595], 'h)': [3053, 3089, 3103, 3162, 3193, 3233, 3298, 3401, 3410, 3545, 3598, 3852], 'assessed': [3055, 3105, 3300, 3547, 3600, 3638, 3722, 3767], 'using': [3059, 3109, 3304, 3362, 3419, 3551, 3604, 3642, 3723, 3771, 3876, 3884, 3891, 4119], 'CM-H2DCFDA.': [3060, 3305, 3552, 3605, 3724, 3772], 'normalized': [3064, 3367, 3425, 3556], 'content.': [3067, 3559], 'n': [3073, 3124, 3255, 3324, 3529, 3565, 3620, 3661, 3739, 3787], 'triplicate.': [3081, 3132, 3263, 3332, 3384, 3442, 3573, 3669, 3747, 3795], '+/−': [3084, 3349, 3538, 3633, 3760, 3840, 3847, 3928, 3987], '(white': [3094, 3335], 'bars)': [3095, 3239, 3336, 3342], '(red': [3098, 3341], 'bars;': [3099], '500': [3100], 'intracellular': [3110, 4199], 'GSH/GSSG': [3111], 'ratios': [3112], 'readout.': [3115], 'Data': [3116, 3306, 3365, 3423, 3443, 3470, 3606, 3647, 3725, 3773, 4012], 'mean': [3120], '±': [3121, 3375, 3433, 4010], 'SEM.': [3122, 4011], 'Immunoblotting': [3133, 3176], 'showing': [3134, 3177, 3206, 3913], 'N-acetylcysteine': [3139, 4170], '(NAC)': [3140], 'PARP': [3142], 'cleavage': [3143], 'indicated': [3146, 3503, 3957, 3992], 'time': [3147, 3958, 3993], 'points': [3148, 3994], 'subjected': [3152, 3412], '(100': [3165, 3244, 3295, 3351, 3407, 3542, 3849], 'h).': [3168], 'GRB2': [3169, 3825], 'loading': [3174, 3201, 3830, 3963], 'indicated.': [3195, 3717, 3824], 'β-actin': [3196], 'Luciferase': [3203], 'reporter': [3204], 'assays': [3205, 4121], 'element': [3209], '(ARE)': [3210], 'activity': [3211], '(left': [3215], 'panel)': [3216, 3221], 'CHLA-10': [3218, 3575, 3925, 3982, 4090, 4111], '(right': [3220], 'presence': [3224, 3812], 'absence': [3226], 'either': [3235], 'untreated': [3236], '(UT;': [3237], 'white': [3238], 'h;': [3247], 'red': [3248], 'bars).': [3249], 'transfected': [3266], 'empty': [3268], 'vector': [3269], 'NRF2-expressing': [3271], 'vector.': [3272], 'Two': [3273], 'days': [3274], 'post-transfection,': [3275], 'presented': [3308, 3608, 3649, 3727, 3775], 'fold': [3310, 3373, 3431, 3516, 3610, 3651, 3729, 3777], 'change': [3311, 3374, 3432, 3517, 3611, 3652, 3730, 3778], 'over': [3312, 3612, 3653, 3731, 3779], 'group.': [3318], 'Total': [3333, 3385, 3866], 'polysome': [3338], 'fractionated': [3339, 3890], 'isolated': [3344], 'assayed': [3356], 'RT–PCR': [3361, 3418], 'primers.': [3364], 'GAPDH': [3369, 3427, 3960], 'polysomal': [3387, 3414], 'fractionation': [3415], 'primers': [3420], 'NFE2L2.': [3422], 'information:': [3444, 4013], 'Unpaired': [3445, 4014], 'two-tailed': [3446, 4015], "Student's": [3447, 4016], 't-test,': [3448], '*P': [3449, 4018], '<': [3450, 3453, 3456, 4019, 4022, 4025], '0.05;': [3451, 4020], '**P': [3452, 4021], '0.005;': [3454, 4023], '***P': [3455, 4024], '0.0005;': [3457, 4026], 'n.s.': [3458], 'non-significant.': [3460, 4029], 'data': [3462, 4031], 'available': [3464, 4033], 'online': [3465, 4034], 'figure.': [3468, 3484, 4037], '[embr201948375-sup-0004-SDataFig1.pdf]': [3474], 'Download': [3475, 3477, 4038, 4040], 'figure': [3476, 4039], 'PowerPoint': [3478, 4041], 'Click': [3479], 'here': [3480], 'expand': [3482], 'EV1.': [3486], 'Increased': [3487], '3D': [3491, 3808], 'A.': [3496], 'Effects': [3497, 3797], 'detected': [3510], 'Incucyte.': [3512], 'The': [3513], 'graph': [3514], 'represents': [3515], 'relative': [3518], 'day': [3520], '0,': [3521], 'error': [3523], 'bar': [3524], 'standard': [3526], 'deviation': [3527], 'experiments.': [3533], 'B.': [3534], 'C.': [3574], 'experiments;': [3624, 3665, 3743, 3791], 'triplicate': [3628], 'D.': [3629], 'fluorogenic': [3644], 'probe,': [3645], 'CellRox.': [3646], 'E.': [3670], 'grown': [3673, 3751, 3806], 'monolayer': [3675], 'cultures': [3676, 3809, 4205], '(2D)': [3677], 'antioxidants': [3684, 3799, 4228, 4246, 4257], 'NAC': [3685, 3765, 4225], '(5': [3686], 'mM)': [3687], 'catalase': [3689, 4227], '(2,000': [3690], 'units/ml),': [3691], 'prior': [3692], 'transfer': [3694], '2D': [3697], 'plates': [3698, 3703, 3758], 'ultra-low': [3700, 3756], 'attachment': [3701, 3757], 'surface': [3702], '(3D)': [3704], 'cultured': [3706, 4176], '18': [3710], 'continuation': [3713], 'then': [3721], 'F.': [3748], 'monolayers': [3753], '(3D−)': [3754], '(3D+)': [3759], 'G.': [3796], 'above,': [3816], 'determined': [3817], 'immunoblotting': [3819], 'cleaved': [3821], 'caspase-3': [3822], 'H.': [3832], 'Fractionation': [3833], 'polysomes': [3835, 3868], 'extracted': [3836], 'sucrose': [3854, 3872], 'gradients': [3855, 3873], 'displays': [3856], 'marked': [3857], 'differences': [3858], 'ribosome': [3860], 'patterns': [3861], 'dependent': [3862], 'displayed': [3864], 'treatments.': [3865], 'separated': [3870], '(10–45%)': [3874], 'prepared': [3875], 'BioComp': [3878, 3893], 'Gradient': [3879, 3894], 'Station': [3880], 'unit': [3881], 'centrifuged': [3883], 'SW60Ti': [3886], 'rotor.': [3887], 'Gradients': [3888], 'Fractionator': [3895], 'equipped': [3896], 'Triax': [3899], 'module': [3900], 'UV': [3904], 'signal': [3905], '(260': [3906], 'nm).': [3907], 'I,': [3908], 'J.': [3909], 'Top': [3910], 'panels:': [3911, 3966], 'Immunoblots': [3912], 'decay': [3916], 'cycloheximide': [3918, 3996], '(CHX)': [3919], 'addition': [3920], '(I)': [3923], '(J)': [3926], 'treatment.': [3930], 'Cells': [3931], 'agent,': [3938], 'SFN': [3939, 3954], '(L-sulforaphane)': [3940], '20': [3942], 'conc': [3944], '4': [3946], 'h.': [3947], 'Then,': [3948], 'CHX': [3949], 'added': [3951], 'along': [3952], 'periods.': [3959], 'controls.': [3964], 'Bottom': [3965], 'Graphical': [3967], 'representation': [3968], 'based': [3973], 'densitometry': [3975], '(top': [3978, 3983], 'panel': [3979, 3984], 'I)': [3980], 'J)': [3985], '(CHX).': [3997], 'Half-lives': [3998], 'shown': [4000], 'curves,': [4003], 'representing': [4004], 'results': [4005], 't-test;': [4017], 'n.s': [4027], 'first': [4043], 'confirmed': [4044, 4118], 'increases': [4047, 4198, 4262], 'NaAsO2-treated': [4051], 'Using': [4054], 'chloromethyl': [4055], '2′,7′-dichlorofluorescin': [4058], 'diacetate': [4059], '(CM-H2DCFDA)': [4060], 'staining': [4061], 'readout,': [4065], 'failed': [4068], 'compared': [4074], '(Figs': [4080, 4106], '1C': [4081, 4107], 'EV1B),': [4083], 'moderately': [4086], 'EV1C).': [4093], 'co-treatment,': [4103], 'EV1B)': [4109], 'EV1C),': [4115], 'CellROX': [4120], 'EV1D).': [4123], 'decreased': [4127], 'ratio': [4129], 'reduced': [4131], 'glutathione': [4136], '(GSH/GSSG),': [4137], 'well-established': [4139], 'readout': [4140], 'tissues,': [4147], '1D),': [4155], 'NaAsO2-co-treated': [4161], 'reversed': [4166, 4223, 4244], 'antioxidant,': [4169], '(NAC;': [4171], 'Fig': [4172], '1E).': [4173], 'next': [4175, 4282], 'non-adherent': [4180], 'suspension': [4181, 4204], 'cultures,': [4182], 'since': [4183], 'detachment': [4186], 'extracellular': [4189], 'matrix,': [4190], 'putative': [4192], 'initial': [4193], '38,': [4197], '39.': [4201], 'Transfer': [4202], 'led': [4206], 'spheroids,': [4212], 'described': [4214], '40;': [4215], 'levels,': [4220], 'EV1E).': [4230], 'Treatment': [4231], 'spheroids': [4234], 'ROS,': [4239], 'again': [4241], 'EV1F),': [4248], 'apoptosis,': [4251], 'blocked': [4255], 'EV1G).': [4259], 'NaAsO2-exposed': [4269], 'non-transcriptionally': [4274], 'large': [4305], 'induction': [4308], 'expected': [4319], 'would': [4323], 'accumulation.': [4332], 'Surprisingly,': [4333], 'NaAs': [4336]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2982674222', 'counts_by_year': [{'year': 2024, 'cited_by_count': 15}, {'year': 2023, 'cited_by_count': 22}, {'year': 2022, 'cited_by_count': 21}, {'year': 2021, 'cited_by_count': 21}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-14T20:24:44.765564', 'created_date': '2019-11-08'}
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