Publication Information

{'id': 'https://openalex.org/W2980948045', 'doi': 'https://doi.org/10.7754/clin.lab.2019.190220', 'title': 'Clinical Application Evaluation of a Fourth-Generation HIV Antigen Antibody Combination Screening Assay', 'display_name': 'Clinical Application Evaluation of a Fourth-Generation HIV Antigen Antibody Combination Screening Assay', 'publication_year': 2019, 'publication_date': '2019-01-01', 'ids': {'openalex': 'https://openalex.org/W2980948045', 'doi': 'https://doi.org/10.7754/clin.lab.2019.190220', 'mag': '2980948045', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31625366'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7754/clin.lab.2019.190220', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S36748825', 'display_name': 'Clinical Laboratory', 'issn_l': '1433-6510', 'issn': ['1433-6510'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4323283984', 'host_organization_name': 'Clinical Laboratory Publications', 'host_organization_lineage': ['https://openalex.org/P4323283984'], 'host_organization_lineage_names': ['Clinical Laboratory Publications'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100779307', 'display_name': 'Hui Han', 'orcid': 'https://orcid.org/0000-0002-8890-4295'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hui Han', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076246085', 'display_name': 'Yanhua Huang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yanhua Huang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102003332', 'display_name': 'Qian Dong', 'orcid': 'https://orcid.org/0000-0002-1038-2116'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Qian Dong', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079883470', 'display_name': 'Yunxiu Huang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yunxiu Huang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013473072', 'display_name': 'Jian‐Qiang Lu', 'orcid': 'https://orcid.org/0000-0003-1945-5569'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jianqiang Lu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100460458', 'display_name': 'Weijia Wang', 'orcid': 'https://orcid.org/0000-0001-8097-9244'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Weijia Wang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100447198', 'display_name': 'Kang Chen', 'orcid': 'https://orcid.org/0000-0003-0276-2474'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kang Chen', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.745, 'has_fulltext': False, 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.664261, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '65', 'issue': '10/2019', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10685', 'display_name': 'Viral-associated cancers and disorders', 'score': 0.9904, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/youdens-j-statistic', 'display_name': "Youden's J statistic", 'score': 0.6543727}, {'id': 'https://openalex.org/keywords/hiv-screening', 'display_name': 'HIV screening', 'score': 0.5936502}, {'id': 'https://openalex.org/keywords/nucleic-acid-test', 'display_name': 'Nucleic acid test', 'score': 0.47000486}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.776747}, {'id': 'https://openalex.org/C43346845', 'wikidata': 'https://www.wikidata.org/wiki/Q8057732', 'display_name': "Youden's J statistic", 'level': 3, 'score': 0.6543727}, {'id': 'https://openalex.org/C2908958731', 'wikidata': 'https://www.wikidata.org/wiki/Q337517', 'display_name': 'HIV screening', 'level': 5, 'score': 0.5936502}, {'id': 'https://openalex.org/C3013748606', 'wikidata': 'https://www.wikidata.org/wiki/Q15787', 'display_name': 'Human immunodeficiency virus (HIV)', 'level': 2, 'score': 0.5749801}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.5585252}, {'id': 'https://openalex.org/C58471807', 'wikidata': 'https://www.wikidata.org/wiki/Q327120', 'display_name': 'Receiver operating characteristic', 'level': 2, 'score': 0.5005522}, {'id': 'https://openalex.org/C64869954', 'wikidata': 'https://www.wikidata.org/wiki/Q1859747', 'display_name': 'False positive paradox', 'level': 2, 'score': 0.49411824}, {'id': 'https://openalex.org/C142462285', 'wikidata': 'https://www.wikidata.org/wiki/Q2528140', 'display_name': 'Viral load', 'level': 3, 'score': 0.476735}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.47277474}, {'id': 'https://openalex.org/C2781369635', 'wikidata': 'https://www.wikidata.org/wiki/Q348667', 'display_name': 'Nucleic acid test', 'level': 5, 'score': 0.47000486}, {'id': 'https://openalex.org/C2780420688', 'wikidata': 'https://www.wikidata.org/wiki/Q759183', 'display_name': 'Immunoassay', 'level': 3, 'score': 0.4516999}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.44710782}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.4405581}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.4352619}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.3060053}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.18747282}, {'id': 'https://openalex.org/C2776939746', 'wikidata': 'https://www.wikidata.org/wiki/Q853451', 'display_name': 'Men who have sex with men', 'level': 4, 'score': 0.08994281}, {'id': 'https://openalex.org/C2776983459', 'wikidata': 'https://www.wikidata.org/wiki/Q41083', 'display_name': 'Syphilis', 'level': 3, 'score': 0.06921348}, {'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C119857082', 'wikidata': 'https://www.wikidata.org/wiki/Q2539', 'display_name': 'Machine learning', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D042241', 'descriptor_name': 'Early Diagnosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D055664', 'descriptor_name': 'Electrochemical Techniques', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D007118', 'descriptor_name': 'Immunoassay', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D008163', 'descriptor_name': 'Luminescent Measurements', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D008403', 'descriptor_name': 'Mass Screening', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000937', 'descriptor_name': 'Antigen-Antibody Reactions', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000937', 'descriptor_name': 'Antigen-Antibody Reactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055664', 'descriptor_name': 'Electrochemical Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005189', 'descriptor_name': 'False Positive Reactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015483', 'descriptor_name': 'HIV Antibodies', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D015483', 'descriptor_name': 'HIV Antibodies', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015483', 'descriptor_name': 'HIV Antibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015483', 'descriptor_name': 'HIV Antibodies', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D016655', 'descriptor_name': 'HIV Core Protein p24', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016655', 'descriptor_name': 'HIV Core Protein p24', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D016655', 'descriptor_name': 'HIV Core Protein p24', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016655', 'descriptor_name': 'HIV Core Protein p24', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D015658', 'descriptor_name': 'HIV Infections', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007118', 'descriptor_name': 'Immunoassay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008163', 'descriptor_name': 'Luminescent Measurements', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008403', 'descriptor_name': 'Mass Screening', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011933', 'descriptor_name': 'Reagent Kits, Diagnostic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011933', 'descriptor_name': 'Reagent Kits, Diagnostic', 'qualifier_ui': 'Q000592', 'qualifier_name': 'standards', 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012680', 'descriptor_name': 'Sensitivity and Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7754/clin.lab.2019.190220', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S36748825', 'display_name': 'Clinical Laboratory', 'issn_l': '1433-6510', 'issn': ['1433-6510'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4323283984', 'host_organization_name': 'Clinical Laboratory Publications', 'host_organization_lineage': ['https://openalex.org/P4323283984'], 'host_organization_lineage_names': ['Clinical Laboratory Publications'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31625366', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.87, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4313385079', 'https://openalex.org/W3164865924', 'https://openalex.org/W2980948045', 'https://openalex.org/W2980009513', 'https://openalex.org/W2946726153', 'https://openalex.org/W2375858805', 'https://openalex.org/W2356765300', 'https://openalex.org/W2152270871', 'https://openalex.org/W2023118090', 'https://openalex.org/W2012874375'], 'abstract_inverted_index': {'Human': [0], 'immunodeficiency': [1, 6], 'virus': [2], 'infection': [3], 'and': [4, 22, 40, 78, 94, 111, 154, 160, 177, 198, 215, 229], 'acquired': [5], 'syndrome': [7], '(HIV/AIDS)': [8], 'are': [9], 'infectious': [10], 'diseases': [11], 'with': [12, 174], 'high': [13], 'mortality.': [14], 'Early': [15], 'diagnosis': [16], 'is': [17, 31], 'crucial.': [18], 'Combining': [19], 'HIV': [20, 27, 35, 71, 75, 91, 112, 121, 147, 189, 196, 230], 'antibody': [21, 92], 'p24': [23], 'antigen,': [24], 'the': [25, 80, 129, 142, 186, 209, 233], 'Elecsys': [26, 188], 'combi': [28], 'PT': [29, 191], 'assay': [30, 44], 'a': [32, 69, 201, 224], 'fourth': [33], 'generation': [34], 'screening': [36, 76], 'assay.': [37], 'The': [38, 116, 151, 163], 'sensitivity': [39], 'specificity': [41], 'of': [42, 48, 64, 73, 82, 99, 168, 181], 'this': [43, 182], 'was': [45, 51, 125, 133, 148, 170], 'examined.A': [46], 'total': [47, 98], '111,556': [49], 'samples': [50, 77], 'conducted': [52, 68], 'from': [53], 'January': [54], '1,': [55], '2016,': [56], 'to': [57, 87, 204, 207], 'June': [58], '30,': [59], '2018': [60], 'in': [61, 172, 232], 'Zhongshan': [62], 'Hospital': [63], 'Yat-Sen': [65], 'University.': [66], 'We': [67], 'fourth-generation': [70, 187], 'test': [72, 192], 'retrospective': [74], 'assessed': [79], 'reliability': [81], 'using': [83], 'signal-to-cutoff': [84], '(S/CO)': [85], 'ratios': [86], 'distinguish': [88], 'false': [89, 96, 122, 165], 'positive': [90, 123, 166], 'reactions': [93], 'analyzed': [95], 'positives.A': [97], '122': [100], 'specimens': [101, 124], 'were': [102, 157], 'confirmed': [103], 'as': [104], 'HIV-1': [105], 'infected': [106, 197], 'by': [107, 211], 'western': [108], 'blot': [109], '(WB)': [110], 'nucleic': [113], 'acid': [114], 'assays.': [115], 'median': [117], 'S/CO': [118], 'ratio': [119], 'for': [120, 128, 146, 226], '3.27,': [126], 'while': [127], 'HIV-infected': [130], 'specimen': [131], 'it': [132], '391.7.': [134], 'Receiver': [135], 'operating': [136], 'characteristic': [137], '(ROC)': [138], 'analysis': [139], 'showed': [140], 'that': [141, 185], 'best': [143], 'diagnostic': [144], 'point': [145], '22.85': [149], 'S/CO.': [150], 'sensitivity,': [152], 'specificity,': [153], 'Youden': [155], 'index': [156], '100%,': [158], '97.8%,': [159], '0.978,': [161], 'respectively.': [162], 'highest': [164], 'rate': [167], '26.4%': [169], 'found': [171], 'patients': [173], 'malignant': [175], 'tumors': [176], 'blood': [178], 'diseases.The': [179], 'results': [180], 'study': [183], 'show': [184], 'combination': [190], 'can': [193, 199], 'identify': [194], 'early': [195], 'be': [200], 'useful': [202], 'adjunct': [203], 'help': [205], 'clinicians': [206], 'manage': [208], 'disease': [210], 'viral': [212], 'load': [213], 'testing': [214, 231], 'starting': [216], 'an': [217], 'appropriate': [218], 'therapy.': [219], 'Our': [220], 'research': [221, 228], 'data': [222], 'provides': [223], 'reference': [225], 'subsequent': [227], 'region.': [234]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2980948045', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}], 'updated_date': '2025-01-12T13:56:27.160239', 'created_date': '2019-10-25'}