DUBs, Hypoxia, and Cancer

Name: Work Video:
Duration: 3 min 30 s
Daniela Mennerich; Kateryna Kubaichuk; Thomas Kietzmann
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'https://openalex.org/W4294718043', 'https://openalex.org/W628038580', 'https://openalex.org/W66751082'], 'related_works': ['https://openalex.org/W4391375266', 'https://openalex.org/W2788277189', 'https://openalex.org/W2130076355', 'https://openalex.org/W2119695867', 'https://openalex.org/W2082860237', 'https://openalex.org/W2046158694', 'https://openalex.org/W2013243191', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418', 'https://openalex.org/W1971568933'], 'abstract_inverted_index': {'Ubiquitylation': [0, 147, 266, 638], 'and': [1, 17, 55, 81, 111, 140, 157, 175, 192, 200, 219, 235, 248, 259, 276, 294, 311, 319, 338, 354, 367, 382, 420, 429, 502, 510, 529, 566, 588, 603, 605, 630, 676, 705, 712, 733, 760, 827, 849, 871, 876, 887, 905, 941, 1005, 1072, 1094, 1116, 1121, 1132, 1150, 1187, 1227, 1231, 1271, 1294, 1317, 1364, 1377, 1386, 1440, 1464, 1488, 1502, 1520, 1560, 1567, 1604, 1642, 1656, 1670, 1700, 1749, 1805, 1811, 1875, 1904, 1911, 1923, 1933, 1947, 1971, 1977, 2028, 2048, 2099, 2116, 2179, 2197, 2201, 2218, 2227, 2273, 2322, 2369, 2397, 2408, 2439, 2463, 2491, 2505, 2521, 2551, 2558, 2570, 2580, 2594, 2618, 2624, 2675, 2695, 2746, 2763, 2827, 2846, 2850, 2867, 2876, 2922, 2971, 3018, 3046, 3057, 3088, 3112, 3141, 3155, 3171, 3207, 3265, 3343, 3368, 3382, 3416, 3492, 3500, 3516, 3522, 3542, 3573, 3616, 3649, 3663, 3697, 3773, 3782, 3798, 3804, 3824, 3856, 3899, 3928, 3947, 3957, 3988, 4001, 4007, 4022, 4068, 4092], 'its': [2, 1701, 3266], 'reversal': [3], 'by': [4, 79, 101, 109, 112, 151, 161, 204, 246, 270, 280, 323, 365, 395, 473, 691, 1426, 1825, 1872, 1962, 1992, 2040, 2131, 2159, 2352, 2487, 2609, 2639, 2687, 2779, 2807, 3001, 3137, 3268, 3352, 3366, 3371, 3386, 3461, 3598, 3647, 3652, 3667, 3742, 3881, 4010], 'DUBs': [5, 106, 193, 201, 218, 245, 312, 320, 337, 364, 592, 597, 626, 1204, 1282, 1350, 1371, 1419, 1439, 1446, 3990], 'is': [6, 58, 99, 148, 208, 214, 267, 327, 333, 376, 399, 407, 456, 470, 517, 582, 639, 647, 681, 746, 991, 1310, 1351, 1409, 1476, 1731, 1846, 1937, 1959, 2060, 2086, 2151, 2175, 2275, 2584, 2606, 2707, 2733, 2799, 2823, 2924, 3195, 3289, 3364, 3384, 3459, 3610, 3645, 3665, 3740, 3893, 3981], 'key': [7, 1534, 2289, 2938], 'in': [8, 61, 72, 96, 137, 253, 256, 372, 402, 438, 487, 507, 613, 636, 653, 660, 684, 748, 833, 993, 1078, 1290, 1361, 1478, 1515, 1549, 1575, 1646, 1716, 1734, 1783, 1817, 1878, 1973, 1979, 1983, 2068, 2079, 2333, 2387, 2398, 2620, 2626, 2630, 2715, 2726, 2982, 3036, 3047, 3279, 3389, 3426, 3585, 3601, 3670, 3707, 3868, 3884, 3934, 4004, 4012, 4016, 4019, 4046, 4071], 'the': [9, 32, 91, 102, 113, 118, 128, 230, 241, 349, 360, 385, 460, 480, 490, 513, 551, 589, 594, 618, 622, 631, 643, 685, 692, 749, 797, 820, 823, 834, 840, 854, 857, 861, 863, 872, 900, 938, 956, 967, 994, 1042, 1065, 1068, 1079, 1085, 1099, 1102, 1106, 1108, 1117, 1145, 1184, 1202, 1237, 1244, 1249, 1255, 1261, 1265, 1272, 1352, 1443, 1459, 1503, 1550, 1564, 1620, 1627, 1630, 1640, 1710, 1717, 1852, 1928, 1940, 1945, 1963, 2021, 2035, 2041, 2055, 2061, 2069, 2076, 2132, 2147, 2193, 2231, 2253, 2256, 2328, 2575, 2587, 2592, 2610, 2668, 2682, 2688, 2702, 2708, 2716, 2723, 2780, 2795, 2842, 2880, 2902, 2905, 2977, 3199, 3239, 3253, 3269, 3273, 3280, 3287, 3290, 3357, 3372, 3377, 3387, 3427, 3446, 3570, 3582, 3586, 3638, 3653, 3658, 3668, 3708, 3727, 3853, 3865, 3869, 3926, 3993], 'control': [10, 3925], 'of': [11, 53, 93, 120, 130, 133, 180, 232, 244, 250, 299, 351, 363, 369, 462, 477, 489, 515, 550, 591, 625, 633, 668, 687, 689, 738, 742, 751, 865, 880, 895, 899, 932, 946, 955, 987, 996, 1110, 1125, 1140, 1144, 1178, 1192, 1201, 1236, 1313, 1322, 1349, 1354, 1379, 1384, 1389, 1397, 1418, 1438, 1445, 1461, 1505, 1513, 1536, 1552, 1582, 1619, 1629, 1639, 1698, 1709, 1753, 1776, 1786, 1803, 1813, 1821, 1851, 1892, 1931, 1957, 1966, 2075, 2146, 2216, 2220, 2255, 2292, 2316, 2325, 2330, 2393, 2423, 2507, 2578, 2604, 2613, 2722, 2794, 2865, 2869, 2904, 2941, 2965, 2974, 2979, 3042, 3072, 3157, 3192, 3204, 3219, 3241, 3245, 3252, 3275, 3282, 3349, 3359, 3376, 3456, 3478, 3488, 3520, 3548, 3614, 3640, 3657, 3737, 3759, 3769, 3802, 3830, 3897, 3931, 3995, 4039, 4061, 4105], 'protein': [12, 138, 173, 257, 292, 380, 389, 392, 1362, 1632, 1781, 1844, 1955, 2058, 2602, 2705, 3503, 3576, 3584, 3785, 3859, 3867], 'homeostasis,': [13, 390], 'degradation,': [14, 83, 2205, 2854, 3295, 3921], 'trafficking,': [15], 'localization,': [16], 'activity.': [18], 'Dysfunction': [19], 'can': [20, 158, 277, 776, 787, 1021, 1032, 1208, 1624], 'lead': [21, 2440, 3089], 'to': [22, 115, 545, 649, 796, 822, 830, 856, 937, 949, 966, 1041, 1067, 1075, 1101, 1183, 1195, 1217, 1421, 1483, 1522, 1570, 1668, 1740, 2082, 2089, 2230, 2278, 2383, 2418, 2441, 2467, 2503, 2729, 2736, 2879, 2927, 3032, 3067, 3090, 3116, 3153, 3260, 3299, 3301, 3341, 3430, 3484, 3495, 3511, 3531, 3545, 3564, 3595, 3711, 3765, 3777, 3793, 3813, 3827, 3847, 3878, 3919, 3976, 3992], 'various': [23, 39, 62, 188, 307, 1431], 'diseases': [24], 'including': [25, 43, 1424], 'cancer.HIFα': [26], 'transcription': [27, 482, 704, 1644, 3206], 'factors': [28, 185, 304, 1645], 'are': [29, 69, 77, 107, 123, 142, 202, 261, 321, 767, 868, 874, 924, 1012, 1113, 1119, 1170, 1205, 1243, 1283, 1343, 1372, 1533, 1541, 1925, 1990, 2128, 2235, 2320, 2349, 2572, 2637, 2776, 2884, 2969, 2998, 3338, 3474, 3755], 'important': [30, 1450, 2386, 3035, 3476, 3757], 'for': [31, 425, 1215, 1340, 1626, 1659, 1683, 1927, 2038, 2049, 2177, 2574, 2685, 2696, 2825, 3293, 3320, 3959], 'physiologic': [33], 'hypoxia': [34, 141, 207, 236, 247, 260, 326, 355, 366, 543, 628, 1514, 1559, 1571, 1669, 1718, 2317, 2394, 2483, 2518, 2966, 3043, 3133, 3168, 3406, 3687], 'response': [35, 1667, 1675, 3429, 3710, 4045], 'but': [36, 1736], 'also': [37, 239, 358, 457, 696, 2023, 2129, 2670, 2777, 3297, 3339, 3441, 3528, 3562, 3722, 3810, 3845], 'affect': [38, 3485, 3766], 'processes': [40], 'during': [41, 2516, 3166, 4043], 'carcinogenesis,': [42], 'ubiquitylation,': [44], 'through': [45], 'known': [46, 215, 334, 583, 1543, 1733], 'and,': [47, 74, 410], 'as': [48, 125, 127, 167, 286, 411, 417, 504, 506, 599, 609, 657, 703, 779, 846, 1024, 1091, 1681, 2003, 2014, 2239, 2406, 2650, 2661, 2888, 3055, 3308, 3410, 3581, 3691, 3864, 3944], 'yet,': [49], 'unknown': [50], 'mechanisms.The': [51], 'abundance': [52, 3191, 3363, 3400, 3644, 3681, 3998], 'HIF-1α': [54, 1603, 1663, 1804, 1932, 2178, 2274, 2442, 2510, 2579, 2826, 2923, 3091, 3160, 3208, 3302, 3417, 3698], 'HIF-2α': [56, 1605, 1671, 1806, 2282, 2931], 'proteins': [57, 68, 478, 690, 745, 990, 1253, 1269], 'largely': [59, 2351, 2400, 3000, 3049], 'increased': [60, 475, 3524, 3806], 'cancers': [63, 488, 2337, 2986], 'with': [64, 145, 264, 378, 459, 519, 627, 920, 1166, 1276, 1563, 1614, 1662, 2095, 2213, 2389, 2742, 2862, 3038, 3249], 'high': [65, 2090, 2737], 'mortality.': [66], 'HIFα': [67, 1622, 1958, 2071, 2605, 2718], 'attractive': [70], 'targets': [71, 612, 3316], 'cancer': [73, 97, 403, 454, 1496, 1516, 3533, 3550, 3815, 3832, 3960, 4028, 4095], 'since': [75, 2181, 2829], 'they': [76, 2234, 2883], 'regulated': [78, 203, 322, 1961, 2608, 3197, 3365, 3460, 3646, 3741], 'ubiquitylation': [80, 139, 177, 258, 296, 396, 553, 680, 2039, 2686, 3264, 3342, 3367, 3648, 3927], 'proteasomal': [82, 134, 391, 1367, 2051, 2204, 2698, 2853, 3344, 3447, 3517, 3728, 3799, 3929], 'DUB': [84, 94, 121, 1278], 'inhibitors': [85, 95, 122, 415, 437], 'may': [86], 'provide': [87], 'a': [88, 209, 328, 412, 520, 547, 640, 780, 831, 847, 1025, 1076, 1092, 1311, 1411, 1435, 1673, 1847, 1899, 1907, 1950, 2138, 2143, 2186, 2242, 2343, 2390, 2419, 2485, 2499, 2546, 2554, 2597, 2786, 2791, 2834, 2891, 2992, 3039, 3068, 3135, 3149, 3411, 3479, 3497, 3611, 3692, 3760, 3779, 3894], 'therapeutic': [89, 611, 1295], 'option.However,': [90], 'use': [92, 249, 368, 632], 'therapy': [98, 404, 432, 1682], 'complicated': [100], 'fact': [103], 'that': [104, 387, 1207, 1413, 1555, 1602, 3984], 'several': [105, 198, 317, 933, 952, 1179, 1198, 1499, 3922, 3985], 'downregulated': [108], 'hypoxia,': [110], 'uncertainty': [114], 'which': [116, 164, 283, 1342, 1359, 1612, 2012, 2085, 2206, 2659, 2732, 2855, 3579, 3862], 'extent': [117], 'action': [119, 1444, 2174, 2822], 'specific/selective,': [124], 'well': [126, 505], 'co-occurrence': [129], 'hypoxia-mediated': [131], 'downregulation': [132], 'components.': [135], 'Alterations': [136, 255], 'commonly': [143, 262], 'associated': [144, 263, 377, 458, 518, 2094, 2741], 'cancer.': [146, 254, 265, 373, 614, 637], 'carried': [149, 268], 'out': [150, 269], 'three': [152, 271, 665, 1542, 1894, 1995, 2541, 2642], 'sequentially': [153, 272], 'acting': [154, 273], 'ubiquitylating': [155, 274], 'enzymes': [156, 275, 671, 674, 1206, 3334], 'be': [159, 278, 546, 788, 1033, 1800, 2384, 3033, 3529, 3596, 3811, 3879], 'opposed': [160, 279], 'deubiquitinases': [162, 281, 586], '(DUBs),': [163, 282], 'have': [165, 284, 422, 606, 3211, 3401, 3682], 'emerged': [166, 285, 608], 'promising': [168, 287, 610], 'drug': [169, 288], 'targets.': [170, 289], 'Apart': [171, 290, 2018, 2665], 'from': [172, 291, 479, 819, 828, 853, 1064, 1073, 1098, 1357, 1366, 2019, 2341, 2414, 2524, 2666, 2990, 3063, 3174], 'localization': [174, 293, 1909, 2556], 'activity,': [176, 295, 3409, 3690], 'regulates': [178, 297, 2460, 3109, 3356, 3637, 4037], 'degradation': [179, 298, 393, 688, 1914, 2506, 2561, 3156, 3267, 3303, 3345, 3370, 3444, 3651, 3725, 3930], 'proteins,': [181, 300, 655, 1358], 'among': [182, 301], 'them': [183, 302], 'hypoxia-inducible': [184, 303, 481, 527, 1583, 1712, 1755, 1814, 1848, 1853, 1873, 1876, 2287, 2936, 3317], '(HIFs).': [186, 305, 485], 'Thereby,': [187, 306, 3940], 'E3': [189, 308, 753, 765, 774, 785, 814, 837, 896, 998, 1010, 1019, 1030, 1059, 1082, 1141, 2045, 2064, 2692, 2711, 3393, 3396, 3471, 3506, 3566, 3589, 3674, 3677, 3752, 3788, 3849, 3872, 3986], 'ubiquitin': [190, 309, 646, 719, 817, 851, 901, 935, 1062, 1096, 1146, 1181, 1245, 1355, 1380, 1390, 3472, 3590, 3753, 3873, 4040], 'ligases': [191, 310, 766, 775, 786, 815, 838, 881, 1011, 1020, 1031, 1060, 1083, 1126, 3397, 3473, 3678, 3754, 3975, 3987], 'regulate': [194, 313, 388, 3512, 3565, 3794, 3848], 'HIF': [195, 211, 314, 330, 552, 595, 1544, 1587, 1896, 2036, 2091, 2135, 2194, 2344, 2445, 2457, 2543, 2683, 2738, 2774, 2783, 2843, 2993, 3094, 3106, 3193, 3205, 3246, 3262, 3276, 3294, 3350, 3360, 3378, 3489, 3559, 3641, 3659, 3770, 3842, 3932, 3977, 3996, 4013], 'abundance.': [196, 315], 'Conversely,': [197, 316, 3841], 'E3s': [199, 318, 866, 870, 1111, 1115], 'hypoxia.': [205, 324], 'While': [206, 325, 542, 812, 1057, 3634], 'powerful': [210, 329, 548], 'regulator,': [212, 331], 'less': [213, 332, 581], 'about': [216, 229, 335, 348, 584, 621, 757, 1002], 'hypoxia-regulated': [217, 336, 585], 'their': [220, 339, 771, 1016, 2208, 2857, 3362, 3643], 'impact': [221, 340, 590], 'on': [222, 341, 593, 770, 1015, 1225, 2252, 2307, 2402, 2901, 2956, 3051, 3198], 'HIFs.': [223, 342, 2497, 3147], 'Here,': [224, 343, 615], 'we': [225, 344, 616], 'review': [226, 345], 'current': [227, 346, 619], 'knowledge': [228, 347, 620], 'relationship': [231, 350], 'E3s,': [233, 352, 802, 1047], 'DUBs,': [234, 353, 1219, 1458], 'signaling.': [237, 356], 'We': [238, 357], 'discuss': [240, 359], 'reciprocal': [242, 361, 623], 'regulation': [243, 362, 686, 1460, 3218, 3481, 3762, 3956, 3994], 'DUB-specific': [251, 370, 634], 'drugs': [252, 371, 635, 1441], 'Cancer': [374, 4075], 'growth': [375, 455, 1778, 3547, 3829], 'excessive': [379], 'synthesis': [381], 'degradation.': [383, 1368, 2052, 2072, 2699, 2719, 3518, 3800], 'Among': [384], 'pathways': [386, 1501, 3924], 'mediated': [394], '(see': [397], 'Glossary)': [398], 'gaining': [400], 'attention': [401], 'because': [405, 2346, 2995], 'it': [406, 695, 1408, 3980], 'highly': [408], 'selective': [409], 'result,': [413, 1436, 2144, 2500, 2792, 3150], 'proteasome': [414, 3288], 'such': [416, 702, 2405, 3054, 3307, 3943], 'bortezomib,': [418], 'carfilzomib,': [419], 'ixazomib': [421], 'been': [423, 3212, 3402, 3683], 'approved': [424], 'mantle': [426], 'cell': [427, 708, 1462, 1486, 1615, 2102, 2749], 'lymphoma': [428], 'multiple': [430, 439, 564, 4023, 4072], 'myeloma': [431, 4024, 4073], '[1Moreau': [433], 'P.': [434, 891, 1136, 1745], 'et': [435, 1288, 1308, 1510, 1580, 1635, 1678, 1707, 1746, 1773, 1809, 1840, 1868, 2155, 2250, 2285, 2453, 2513, 2803, 2899, 2934, 3102, 3163, 3216, 3313, 3454, 3537, 3608, 3735, 3819, 3891, 4035, 4059, 4087], 'al.Proteasome': [436], 'myeloma:': [440], '10': [441], 'years': [442], 'later.Blood.': [443], '2012;': [444, 723, 1297, 1763, 3230], '120:': [445], '947-959Crossref': [446], 'PubMed': [447, 537, 577, 726, 913, 1158, 1300, 1334, 1402, 1470, 1528, 1594, 1691, 1726, 1766, 1792, 1833, 1861, 1885, 2167, 2268, 2301, 2478, 2535, 2815, 2917, 2950, 3127, 3185, 3233, 3328, 3436, 3556, 3629, 3717, 3838, 3912, 3968, 4080, 4100], 'Scopus': [448, 538, 727, 914, 1159, 1301, 1335, 1403, 1471, 1595, 1692, 1727, 1767, 1793, 1834, 1862, 1886, 2168, 2269, 2302, 2479, 2536, 2816, 2918, 2951, 3128, 3186, 3234, 3329, 3630, 3913, 3969, 4081, 4101], '(300)': [449], 'Google': [450, 540, 578, 729, 916, 1161, 1303, 1337, 1405, 1473, 1529, 1597, 1694, 1729, 1769, 1795, 1836, 1864, 1888, 2125, 2170, 2271, 2304, 2378, 2481, 2538, 2772, 2818, 2920, 2953, 3027, 3130, 3188, 3236, 3331, 3437, 3557, 3632, 3718, 3839, 3915, 3971, 4083, 4103], 'Scholar].': [451, 541, 1162, 1406, 1474, 1530, 1598, 1652, 1695, 2171, 2305, 2379, 2539, 2773, 2819, 2954, 3028, 3131, 3189, 3237, 3332, 3438, 3468, 3633, 3719, 3749, 3840, 3916], 'In': [452, 755, 860, 1000, 1105, 1369, 2428, 3077, 3238, 3271, 3568, 3775, 3851, 3917], 'addition,': [453, 1370], 'development': [461], 'limited': [463], 'oxygenation': [464], '(commonly': [465], 'called': [466], 'tumor': [467, 601, 781, 1026, 1490, 1506, 2056, 2109, 2362, 2703, 2756, 3011], 'hypoxia).': [468], 'This': [469, 663, 1653], 'often': [471, 777, 1022], 'exemplified': [472], 'an': [474, 1314, 1449, 1665, 1912, 2260, 2559, 2909, 3475, 3621, 3756, 3904, 3935], 'amount': [476], 'factor-α': [483], 'family': [484, 1279, 1321, 2000, 2647], 'Commonly,': [486], 'bladder,': [491], 'brain,': [492], 'breast,': [493], 'colon,': [494], 'esophagus,': [495], 'head/neck,': [496], 'liver,': [497], 'lung,': [498], 'pancreas,': [499], 'skin,': [500], 'stomach,': [501], 'uterus,': [503], 'acute': [508, 1666], 'lymphocytic': [509], 'myeloid': [511], 'leukemias,': [512], 'appearance': [514], 'HIFs': [516, 1532, 2202, 2851], 'poor': [521], 'prognosis': [522], '[2Semenza': [523], 'G.L.': [524], 'Oxygen': [525], 'sensing,': [526], 'factors,': [528], 'disease': [530, 1257], 'pathophysiology.Annu.': [531], 'Rev.': [532, 721], 'Pathol.': [533], '2014;': [534], '9:': [535], '47-71Crossref': [536], '(404)': [539], 'appears': [544], 'regulator': [549], 'process': [554, 641], '[3Ivan': [555], 'M.': [556, 717, 1706], 'Kaelin': [557], 'Jr.,': [558, 2105, 2358, 2752, 3007], 'W.G.': [559, 2106, 2359, 2753, 3008], 'The': [560, 718, 985, 1211, 1229, 1346, 1531, 1696, 1919, 1935, 1954, 1988, 2030, 2073, 2107, 2172, 2360, 2566, 2582, 2601, 2635, 2677, 2720, 2754, 2820, 3009, 3190, 3374, 3655], 'EGLN-HIF': [561], 'O2-sensing': [562], 'system:': [563], 'inputs': [565], 'feedbacks.Mol.': [567], 'Cell.': [568, 1325, 3228, 3624, 3907], '2017;': [569, 1400, 1591, 2122, 2375, 2769, 3024, 3553, 3835, 4077], '66:': [570], '772-779Abstract': [571], 'Full': [572, 574, 1329, 1331, 2473, 2475, 3122, 3124], 'Text': [573, 575, 1330, 1332, 2474, 2476, 3123, 3125], 'PDF': [576, 1333, 2477, 3126], 'Scholar],': [579, 1338, 1796], 'much': [580], '(DUBs)': [587], 'system.': [596], 'act': [598, 778, 845, 1023, 1090], 'both': [600, 2225, 2874, 3486, 3767], 'suppressors': [602], 'oncogenes': [604], 'thus': [607], 'summarize': [617], 'connection': [624], 'signaling': [629, 1432, 3923, 4014], 'where': [642, 2318, 2421, 2967, 3070], 'small': [644], 'molecule': [645], 'attached': [648], 'lysine': [650, 832, 1077], '(K)': [651, 954, 1200], 'residues': [652, 1969, 2616], 'target': [654, 744, 939, 989, 1185, 1576, 2221, 2870], 'either': [656], 'monoubiquitin': [658], 'or': [659, 783, 803, 951, 1028, 1048, 1197, 1416, 1428, 2005, 2652], 'polyubiquitin': [661, 947, 1193], 'chains.': [662], 'requires': [664, 2024, 2671], 'different': [666, 752, 764, 921, 997, 1009, 1167, 1895, 2542, 3989], 'types': [667, 3487, 3768], 'enzymes:': [669], 'ubiquitin-activating': [670], '(E1),': [672], 'ubiquitin-conjugating': [673, 960], '(E2),': [675], 'ubiquitin-ligases': [677], '(E3).': [678], 'Although': [679, 2224, 2873, 3286], 'mainly': [682], 'involved': [683, 1373], '26S': [693], 'proteasome,': [694], 'affects': [697], 'many': [698, 1422, 1479], 'other': [699, 877, 1122, 1241, 1631], 'cellular': [700, 2015, 2662, 3428, 3709], 'processes,': [701], 'DNA': [706, 4066], 'repair,': [707], 'cycle': [709], 'control,': [710], 'inflammation,': [711], 'apoptosis': [713, 4070], '[4Komander': [714], 'D.': [715, 2249, 2898], 'Rape': [716], 'code.Annu.': [720], 'Biochem.': [722], '81:': [724], '203-229Crossref': [725], '(1254)': [728], 'Scholar]': [730, 1730, 2272, 2921, 3972], '(Figure': [731, 1917, 1986, 2564, 2633], '1': [732, 4000], 'Box': [734], '1).Box': [735], '1Functional': [736], 'Consequences': [737], 'Protein': [739], 'UbiquitylationThe': [740], 'diversity': [741, 986], 'ubiquitin-modified': [743, 988], 'reflected': [747, 992], 'number': [750, 995], 'enzymes.': [754, 999], 'humans,': [756, 1001], '30–40': [758, 1003], 'E2': [759, 821, 855, 1004, 1066, 1100], 'more': [761, 1006, 2276, 2925, 3224], 'than': [762, 1007, 2246, 2281, 2355, 2895, 2930, 3004, 3225], '600': [763, 1008], 'known.': [768, 1013], 'Depending': [769, 1014], 'substrate': [772, 858, 1017, 1103, 3613, 3896], 'specificity,': [773, 1018], 'suppressor': [782, 1027, 2057, 2110, 2363, 2704, 2757, 3012, 3539, 3821], 'oncogene.': [784, 1029], 'divided': [789, 1034, 1220], 'into': [790, 1035, 1221, 2113, 2366, 2760, 3015], 'two': [791, 1036, 1621, 1901, 1967, 2548, 2614], 'main': [792, 1037], 'classes:': [793, 1038], '(i)': [794, 926, 1039, 1172, 1375], 'homologous': [795, 965, 1040], 'E6-AP-carboxyl': [798, 968, 1043], 'terminus': [799, 1044], '(HECT)': [800, 1045], 'domain': [801, 810, 1046, 1055, 1258, 1843, 1915, 2562], '(ii)': [804, 928, 1049, 1174, 1382], 'really': [805, 971, 1050], 'interesting': [806, 972, 1051], 'new': [807, 973, 1052, 1292, 1320, 3424, 3705], 'gene': [808, 1053, 1584, 1742, 1750, 1823, 1870, 2078, 2222, 2494, 2725, 2871, 3144], '(RING)': [809, 1054], 'E3s.': [811, 1056], 'HECT': [813, 824, 875, 1058, 1069, 1120], 'transfer': [816, 850, 1061, 1095], 'first': [818, 1063], 'active-site': [825, 1070], 'cysteine': [826, 1071, 1284], 'there': [829, 1074, 3223], 'substrate,': [835, 1080], 'RING': [836, 1081], '(and': [839, 1084], 'structurally': [841, 1086, 1318], 'related': [842, 1087], 'U-box': [843, 1088], 'E3s)': [844, 1089], 'scaffold': [848, 1093], 'directly': [852, 1097, 1427], 'lysine.': [859, 1104], 'cell,': [862, 1107], 'majority': [864, 1109], '(∼92%)': [867, 1112], 'RING-domain-containing': [869, 1114], 'rest': [873, 1118], 'smaller': [878, 1123], 'families': [879, 1124], '(plant': [882, 1127], 'homology': [883, 1128], 'domain,': [884, 1129], 'zinc': [885, 1130], 'finger,': [886, 1131], 'U-box)': [888, 1133], '[87De': [889, 1134], 'Bie': [890, 1135], 'Ciechanover': [892, 1137], 'A.': [893, 1138, 2512, 2531, 3162, 3181, 3215, 4086], 'Ubiquitination': [894, 1139], 'ligases:': [897, 1142], 'self-regulation': [898, 1143], 'system': [902, 1147], 'via': [903, 1148, 2496, 3146, 3445, 3514, 3620, 3726, 3796, 3903, 4030], 'proteolytic': [904, 1149], 'non-proteolytic': [906, 1151], 'mechanisms.Cell': [907, 1152], 'Death': [908, 1153], 'Differ.': [909, 1154], '2011;': [910, 1155, 1723], '18:': [911, 1156], '1393-1402Crossref': [912, 1157], '(118)': [915, 1160], 'Scholar].Three': [917], 'major': [918, 1164, 1347], 'ubiquitylations': [919, 1165], 'functional': [922, 1168], 'consequences': [923, 1169], 'known:': [925, 1171], 'mono-ubiquitylation;': [927, 1173], 'multi-ubiquitylation': [929, 1175], '(i.e.,': [930, 1176, 3937], 'attachment': [931, 945, 1177, 1191], 'single': [934, 1180], 'molecules': [936, 1182], 'protein);': [940, 1186], '(iii)': [942, 1188, 1387], 'polyubiquitylation': [943, 1189, 3515, 3797], '[i.e.,': [944, 1190], 'chains': [948, 1194, 1356, 1391], 'one': [950, 1196], 'lysines': [953, 1199], 'substrate].Figure': [957], 'IAbbreviations:': [958], 'E2,': [959], 'enzyme;': [961], 'E3,': [962], 'ubiquitin-ligase;': [963], 'HECT,': [964], 'terminus;': [969], 'RING,': [970], 'gene;': [974], 'Ub,': [975], 'ubiquitin.View': [976], 'Large': [977], 'Image': [978], 'Figure': [979], 'ViewerDownload': [980], 'Hi-res': [981], 'image': [982], 'Download': [983], '(PPT)': [984], 'Three': [1163], 'substrate].': [1203], 'reverse': [1209], 'ubiquitylation.': [1210], 'human': [1212, 1711, 1818, 1974, 1980, 1984, 2621, 2627, 2631], 'genome': [1213], 'encodes': [1214], 'up': [1216], '100': [1218], 'seven': [1222, 3388, 3669], 'subgroups,': [1223], 'depending': [1224, 2401, 3050], 'sequence': [1226], 'structure.': [1228], 'largest': [1230], 'most': [1232], 'heterogeneous': [1233], 'group': [1234], 'consists': [1235], 'ubiquitin-specific': [1238], 'proteases': [1239, 1263, 1285], '(USPs);': [1240], 'groups': [1242], 'carboxyl-terminal': [1246], 'hydrolases': [1247], '(UCHs),': [1248], 'otubain/ovarian': [1250], 'tumor-domain': [1251], 'containing': [1252, 1606, 3505, 3787], '(OTUs),': [1254], 'Machado-Joseph': [1256], 'superfamily': [1259], '(MJDs),': [1260], 'JAB1/MPN/MOV34': [1262], '(JAMMs),': [1264], 'monocyte': [1266], 'chemotactic': [1267], 'protein-induced': [1268], '(MCPIPs),': [1270], 'novel': [1273], 'motif': [1274], 'interacting': [1275], 'ubiquitin-containing': [1277], '(MINDY).': [1280], 'All': [1281, 2540], '[5Fraile': [1286], 'J.M.': [1287], 'al.Deubiquitinases': [1289], 'cancer:': [1291], 'functions': [1293, 1658], 'options.Oncogene.': [1296], '31:': [1298], '2373-2388Crossref': [1299], '(223)': [1302], 'Scholar,': [1304, 1770, 1837, 1865, 4056, 4084], '6Abdul': [1305], 'Rehman': [1306], 'S.A.': [1307], 'al.MINDY-1': [1309], 'member': [1312], 'evolutionarily': [1315], 'conserved': [1316], 'distinct': [1319, 1609, 1657], 'deubiquitinating': [1323], 'enzymes.Mol.': [1324], '2016;': [1326, 4053], '63:': [1327], '146-155Abstract': [1328], '(82)': [1336], 'except': [1339], 'JAMMs,': [1341], 'Zn2+': [1344], 'metalloproteases.': [1345], 'role': [1348, 1512], 'removal': [1353], 'results': [1360], 'stabilization': [1363, 2324, 2973], 'protection': [1365], 'in:': [1374], 'processing': [1376], 'maturation': [1378], 'precursors,': [1381], 'recycling': [1383], 'ubiquitin,': [1385], 'editing': [1388], '[7Haq': [1392], 'S.': [1393, 1395, 1808, 2154, 2530, 2802, 3180], 'Ramakrishna': [1394], 'Deubiquitylation': [1396], 'deubiquitylases.Open': [1398], 'Biol.': [1399, 1856, 2162, 2810, 3323, 3625, 3908], '7170016Crossref': [1401], '(4)': [1404, 1693], 'Thus,': [1407, 3979], 'not': [1410, 1732, 2236, 2339, 2885, 2988, 3982], 'surprise': [1412], 'inappropriate': [1414], 'activity': [1415, 1930, 2254, 2312, 2577, 2903, 2961, 3358, 3639], 'expression': [1417, 1585, 1743, 1751, 1824, 2495, 3145, 4038], 'contributes': [1420], 'diseases,': [1423], 'cancer,': [1425], 'indirectly': [1429], 'affecting': [1430], 'pathways.': [1433], 'As': [1434, 2142, 2498, 2790, 3148], 'exploration': [1437], 'modifying': [1442], 'has': [1447, 2241, 2890], 'become': [1448, 1556, 2199, 2848], 'research': [1451], 'focus': [1452], 'world-wide': [1453], '[8Heideker': [1454], 'J.': [1455, 1466, 1757, 2264, 2452, 2913, 3101], 'Wertz': [1456], 'I.E.': [1457], 'identity': [1463], 'disease.Biochem.': [1465], '2015;': [1467, 1525, 2164, 2812, 3965], '465:': [1468], '1-26Crossref': [1469], '(0)': [1472, 1728, 1768, 1794, 1863, 2480, 2537, 3129, 3187, 3235, 3631, 3914], 'Hypoxia': [1475, 4005], 'seen': [1477], 'solid': [1480], 'tumors': [1481, 2348, 2997], 'due': [1482, 2088, 2735], 'rapidly': [1484], 'increasing': [1485, 1489], 'proliferation': [1487], 'mass.': [1491], 'To': [1492], 'overcome': [1493], 'low': [1494], 'oxygen,': [1495, 3242], 'cells': [1497, 2523, 3173], 'activate': [1498, 1741], 'survival': [1500], 'formation': [1504], 'vasculature': [1507], '[9Muz': [1508], 'B.': [1509, 3964], 'al.The': [1511, 2286, 2454, 2935, 3103], 'progression,': [1517], 'angiogenesis,': [1518], 'metastasis,': [1519], 'resistance': [1521], 'therapy.Hypoxia': [1523], '(Auckl).': [1524], '3:': [1526, 3434, 3715, 4054], '83-92Crossref': [1527], 'regulators': [1535, 1802, 2291, 2940], 'this': [1537, 2430, 2501, 3079, 3151], 'adaptive': [1538], 'program.': [1539], 'There': [1540], 'α-subunits': [1545, 1897, 2037, 2127, 2544, 2684, 2775, 3194, 3277, 3933], '(Box': [1546, 3284, 3346], '2)': [1547], 'labile': [1548], 'presence': [1551, 2329, 2978, 3240], 'oxygen': [1553, 2114, 2190, 2261, 2367, 2761, 2839, 2910, 3016, 3283, 3354, 3635, 3936], '(O2)': [1554], 'stabilized': [1557, 3418, 3699], 'under': [1558, 3221, 3304, 3449, 3463, 3730, 3744], 'form': [1561], 'heterodimers': [1562], 'beta-subunit': [1565], 'ARNT': [1566], 'then': [1568], 'bind': [1569], 'responsive': [1572], 'elements': [1573], '(HREs)': [1574], 'genes': [1577], '[10Suzuki': [1578], 'N.': [1579], 'al.Regulation': [1581], 'after': [1586], 'activation.Exp.': [1588], 'Cell': [1589], 'Res.': [1590, 1828, 1881, 4076], '356:': [1592], '182-186Crossref': [1593], '(9)': [1596], 'Recent': [1599], 'findings': [1600, 2413, 3062], 'indicate': [1601], 'complexes': [1607], 'occupy': [1608], 'genomic': [1610], 'sites,': [1611], 'vary': [1613], 'type.': [1616], 'Further,': [1617, 2327, 2976], 'none': [1618], 'subunits': [1623], 'compensate': [1625], 'lack': [1628], '[11Smythies': [1633], 'J.A.': [1634], 'al.Inherent': [1636], 'DNA-binding': [1637], 'specificities': [1638], 'HIF-1alpha': [1641, 3220, 3953], 'HIF-2alpha': [1643, 1680], 'chromatin.EMBO': [1647], 'Rep.': [1648], '2019;': [1649, 4097], 'e46401:': [1650], '20Google': [1651], 'suggests': [1654], 'overlapping': [1655], 'these': [1660, 2347, 2996], 'subunits,': [1661], 'promoting': [1664, 1672], 'chronic': [1674, 2517, 3167], '[12Murugesan': [1676], 'T.': [1677], 'al.Targeting': [1679], 'advanced': [1684], 'cancers.Drug': [1685], 'Discov.': [1686], 'Today.': [1687], '2018;': [1688, 2470, 3119], '23:': [1689, 4078], '1444-1451Crossref': [1690], 'function': [1697, 2013, 2660], 'HIF-3α': [1699, 1942, 2184, 2589, 2832], 'numerous': [1702], 'splice': [1703], 'variants': [1704, 1715, 1738], '[13Heikkila': [1705], 'al.Roles': [1708], 'factor': [1713, 1779, 1815, 2133, 2455, 2781, 3104], '(HIF)-3alpha': [1714, 1816], 'response.Cell.': [1719], 'Mol.': [1720, 2295, 2944], 'Life': [1721, 2296, 2945], 'Sci.': [1722, 2297, 2528, 2946, 3178], '68:': [1724], '3885-3901Crossref': [1725], 'detail,': [1735], 'some': [1737], 'appear': [1739, 3298], '[14Zhang': [1744], 'al.Molecular,': [1747], 'functional,': [1748], 'analysis': [1752], 'zebrafish': [1754], 'factor-3alpha.Am.': [1756], 'Physiol.': [1758, 1762, 3229], 'Regul.': [1759], 'Integr.': [1760], 'Comp.': [1761], '303:': [1764], 'R1165-R1174Crossref': [1765], '15Scharf': [1771], 'J.G.': [1772], 'al.Oxygen-dependent': [1774], 'modulation': [1775], 'insulin-like': [1777], 'binding': [1780], 'biosynthesis': [1782], 'primary': [1784, 3291], 'cultures': [1785], 'rat': [1787], 'hepatocytes.Endocrinology.': [1788], '2005;': [1789, 1882], '146:': [1790], '5433-5443Crossref': [1791], 'while': [1797], 'others': [1798], 'might': [1799], 'negative': [1801], '[16Hara': [1807], 'al.Expression': [1810], 'characterization': [1812], 'kidney:': [1819], 'suppression': [1820], 'HIF-mediated': [1822], 'HIF-3alpha.Biochem.': [1826], 'Biophys.': [1827], 'Commun.': [1829], '2001;': [1830], '287:': [1831], '808-813Crossref': [1832], '(172)': [1835], '17Makino': [1838], 'Y.': [1839], 'al.Inhibitory': [1841], 'PAS': [1842], '(IPAS)': [1845], 'splicing': [1849], 'variant': [1850], 'factor-3alpha': [1854], 'locus.J.': [1855], 'Chem.': [1857, 2163, 2811, 3324], '2002;': [1858], '277:': [1859], '32405-32408Crossref': [1860], '18Wang': [1866], 'V.': [1867], 'al.Differential': [1869], 'up-regulation': [1871], 'factor-1alpha': [1874, 3318], 'factor-2alpha': [1877], 'HEK293T': [1879], 'cells.Cancer': [1880, 3551, 3833], '65:': [1883], '3299-3306Crossref': [1884], '(60)': [1887], 'Scholar].Box': [1889], '2Oxygen-Dependent': [1890], 'Degradation': [1891], 'HIFsAll': [1893], 'contain': [1898, 2545], 'bHLH,': [1900, 2547], 'Per-ARNT-Sim': [1902, 2549], '(PAS-A': [1903, 2550], 'PAS-B)': [1905, 2552], 'domains,': [1906, 2553], 'nuclear': [1908, 2210, 2555, 2859], 'signal,': [1910, 2557], 'oxygen-dependent': [1913, 1964, 2070, 2560, 2611, 2717, 3243, 3602, 3622, 3885, 3905, 3920], '(ODD)': [1916, 2563], 'IA).': [1918, 2565], 'transactivation': [1920, 2188, 2567, 2836], 'domains': [1921, 2568], '(N-TAD': [1922, 2569], 'C-TAD)': [1924, 2571], 'required': [1926, 2573], 'transcriptional': [1929, 2148, 2290, 2576, 2796, 2939], 'HIF-2α.': [1934, 2581], 'ODD': [1936, 2583], 'located': [1938, 2585], 'within': [1939, 2586], 'N-TAD.': [1941, 2588], 'subunit': [1943, 2590], 'lacks': [1944, 2185, 2591, 2833], 'C-TAD': [1946, 2593], 'instead': [1948, 2595], 'contains': [1949, 2596], 'leucine-zipper': [1951, 2598], '(L-ZIP)': [1952, 2599], 'domain.': [1953, 2600, 2837], 'stability': [1956, 2603, 3274, 3375, 3656], 'primarily': [1960, 2607], 'hydroxylation': [1965, 2033, 2157, 2612, 2680, 2805, 3244, 3336, 3612, 3895], 'proline': [1968, 1996, 2031, 2615, 2643, 2678], '(P402': [1970, 2617], 'P564': [1972, 2619], 'HIF-1α;': [1975, 2622], 'P405': [1976, 2623], 'P531': [1978, 2625], 'HIF-2α;': [1981, 2628], 'P492': [1982, 2629], 'HIF-3α)': [1985, 2632], 'IB).': [1987, 2634], 'hydroxylations': [1989, 2636], 'performed': [1991, 2638], 'at': [1993, 2137, 2313, 2508, 2640, 2785, 2962, 3158], 'least': [1994, 2509, 2641, 3159], '4-hydroxylase': [1997, 2644], 'domain-containing': [1998, 2645], 'enzyme': [1999, 2646, 4063], 'members': [2001, 2648], '[known': [2002, 2649], 'PHD1-3': [2004, 2651], 'EGL': [2006, 2653], 'Nine': [2007, 2654], '(Caenorhabditis': [2008, 2655], 'elegans)': [2009, 2656], 'Homologs': [2010, 2657], '(EGLN1-3)],': [2011, 2658], 'O2': [2016, 2244, 2434, 2663, 2893, 3083], 'sensors.': [2017, 2664], 'O2,': [2020, 2667], 'reaction': [2022, 2669], '2-oxoglutarate': [2025, 2672], '(2-OG),': [2026, 2673], 'Fe2+,': [2027, 2674], 'ascorbate.': [2029, 2676], 'residue': [2032, 2679], 'tags': [2034, 2681], 'von': [2042, 2689, 3254], 'Hippel-Lindau': [2043, 2690, 3255], '(VHL)-containing': [2044, 2691], 'ligase': [2046, 2065, 2693, 2712, 3507, 3591, 3789, 3874], 'complex': [2047, 2694, 3508, 3790], 'subsequent': [2050, 2697, 3250, 3369, 3650], 'So': [2053, 2700], 'far,': [2054, 2701], 'VHL': [2059, 2077, 2083, 2108, 2361, 2706, 2724, 2730, 2755, 3010], 'only': [2062, 2709], 'reported': [2063, 2710, 3510, 3563, 3792, 3846], 'substrate-recognition': [2066, 2713], 'component': [2067, 2714], 'mutation': [2074, 2721], 'patients': [2080, 2727], 'leads': [2081, 2502, 2728, 3152, 3259], 'syndrome,': [2084, 2731], '(also': [2087, 2734], 'levels)': [2092, 2739], 'frequently': [2093, 2740], 'angiomatosis,': [2096, 2743], 'hemangioblastomas,': [2097, 2744], 'pheochromocytomas,': [2098, 2745], 'renal': [2100, 2747], 'clear': [2101, 2748], 'carcinomas': [2103, 2750], '[92Kaelin': [2104, 2357, 2751, 3006], 'gene:': [2111, 2364, 2758, 3013], 'insights': [2112, 2365, 2759, 3014], 'sensing': [2115, 2368, 2762, 3017], 'cancer.Trans.': [2117, 2370, 2764, 3019], 'Am.': [2118, 2371, 2765, 3020], 'Clin.': [2119, 2372, 2766, 3021], 'Climatol.': [2120, 2373, 2767, 3022], 'Assoc.': [2121, 2374, 2768, 3023], '128:': [2123, 2376, 2770, 3025], '298-307PubMed': [2124, 2377, 2771, 3026], 'Scholar].HIF': [2126], 'hydroxylated': [2130, 2778, 3597, 3880], 'inhibiting': [2134, 2456, 2782, 3105], '(FIH)': [2136, 2784], 'C-terminal': [2139, 2187, 2787, 2835], 'asparagine': [2140, 2788], 'residue.': [2141, 2789], 'recruitment': [2145, 2215, 2793, 2864, 3251], 'coactivator': [2149, 2797], 'p300': [2150, 2798], 'prevented': [2152, 2800], '[93Markolovic': [2153, 2801], 'al.Protein': [2156, 2804], 'catalyzed': [2158, 2806], '2-oxoglutarate-dependent': [2160, 2808], 'oxygenases.J.': [2161, 2809], '290:': [2165, 2813], '20712-20722Crossref': [2166, 2814], '(59)': [2169, 2817], 'latter': [2173, 2821], 'specific': [2176, 2824, 4041], 'HIF-2α,': [2180, 2828], 'even': [2182, 2830], 'full-length': [2183, 2831], 'domain.If': [2189], 'becomes': [2191, 2840], 'limited,': [2192, 2841], 'prolyl': [2195, 2844, 3379, 3660], '4-hydroxylases': [2196, 2845, 3380, 3661], 'FIH': [2198, 2226, 2240, 2279, 2309, 2332, 2381, 2424, 2847, 2875, 2889, 2928, 2958, 2981, 3030, 3073, 3443, 3458, 3615, 3724, 3739, 3898], 'inhibited': [2200, 2849], 'escape': [2203, 2852], 'allows': [2207, 2856], 'accumulation,': [2209, 2858], 'transport,': [2211, 2860], 'heterodimerization': [2212, 2861], 'ARNT,': [2214, 2863], 'coactivators,': [2217, 2866], 'activation': [2219, 2868], 'expression.': [2223, 2872], 'PHDs': [2228, 2319, 2877, 2968, 3491, 3772], 'belong': [2229, 2878], '2-OG-dependent': [2232, 2881], 'dioxygenases,': [2233, 2882], 'functionally': [2237, 2886], 'redundant': [2238, 2887], 'higher': [2243, 2892], 'affinity': [2245, 2894], 'PHD': [2247, 2437, 2896, 3086], '[94Ehrismann': [2248, 2897], 'al.Studies': [2251, 2900], 'hypoxia-inducible-factor': [2257, 2906], 'hydroxylases': [2258, 2907, 3560, 3843], 'using': [2259, 2908], 'consumption': [2262, 2911], 'assay.Biochem.': [2263, 2912], '2007;': [2265, 2914, 3626, 3909], '401:': [2266, 2915], '227-234Crossref': [2267, 2916], '(140)': [2270, 2919], 'susceptible': [2277, 2926], 'modification': [2280, 2929], '[95Bracken': [2283, 2932], 'C.P.': [2284, 2933], 'factors:': [2288, 2937], 'hypoxic': [2293, 2449, 2942, 3098, 3450, 3731, 4044], 'responses.Cell.': [2294, 2943], '2003;': [2298, 2947], '60:': [2299, 2948], '1376-1393Crossref': [2300, 2949], '(162)': [2303, 2952], 'Based': [2306, 2955], 'this,': [2308, 2957], 'maintains': [2310, 2959], 'sufficient': [2311, 2960], 'intermediate': [2314, 2963], 'levels': [2315, 2964, 3526, 3808], 'inactive': [2321, 2970], 'enable': [2323, 2972], 'HIF-1α.': [2326, 2975], 'active': [2331, 2980], 'normoxic': [2334, 2983, 3464, 3745], 'pVHL-defective': [2335, 2984], 'kidney': [2336, 2985], 'does': [2338, 2987], 'prevent': [2340, 2989], '-involving': [2342, 2991], 'program': [2345, 2994], 'driven': [2350, 2999], 'HIF-2': [2353, 3002], 'rather': [2354, 3003], 'HIF-1': [2356, 3005], 'However,': [2380, 3029], 'seems': [2382, 3031], 'physiologically': [2385, 3034], 'situations': [2388, 3037], 'rapid': [2391, 3040, 3261], 'onset': [2392, 3041], '(e.g.,': [2395, 3044], 'ischemia)': [2396, 3045], 'tissues': [2399, 3048], 'oxidative': [2403, 2426, 2461, 3052, 3075, 3110], 'metabolism,': [2404, 3053], 'heart': [2407, 3056], 'skeletal': [2409, 3058], 'muscle.': [2410, 3059], 'Indeed,': [2411, 3060], 'recent': [2412, 3061], 'FIH-deficient': [2415, 3064], 'mice': [2416, 3065], 'led': [2417, 3066], 'model': [2420, 3069], 'loss': [2422, 3071], 'accelerates': [2425, 2464, 3074, 3113], 'processes.': [2427, 3076], 'turn,': [2429, 3078], 'would': [2431, 2447, 3080, 3096], 'reduce': [2432, 3081], 'intracellular': [2433, 3082], 'levels,': [2435, 3084], 'potentiate': [2436, 3085], 'inhibition,': [2438, 3087], 'accumulation.': [2443, 3092], 'Consequently,': [2444, 3093], 'accumulation': [2446, 3095], 'promote': [2448, 3097], 'adaptation': [2450, 2466, 3099, 3115], '[96Sim': [2451, 3100], 'asparaginyl': [2458, 3107], 'hydroxylase': [2459, 3108], 'metabolism': [2462, 3111], 'metabolic': [2465, 3114], 'hypoxia.Cell': [2468, 3117, 3431, 3712], 'Metab.': [2469, 3118], '27:': [2471, 3120, 3627, 3910], '898-913Abstract': [2472, 3121], 'Scholar].Importantly,': [2482], 'promotes': [2484, 3134, 3617, 3900], 'feedback': [2486, 3136, 3480, 3761], 'activating': [2488, 3138], 'EGLN1': [2489, 3139], '(PHD2)': [2490, 3140], 'EGLN3': [2492, 3142], '(PHD3)': [2493, 3143], 'rehydroxylation': [2504, 3154], '[97Ginouvès': [2511, 3161], 'al.PHDs': [2514, 3164], 'overactivation': [2515, 3165], "'desensitizes'": [2519, 3169], 'HIFa': [2520, 3170], 'protects': [2522, 3172], 'necrosis.Proc.': [2525, 3175], 'Natl.': [2526, 3176], 'Acad.': [2527, 3177], 'U.': [2529, 3179], '2008;': [2532, 3182], '105:': [2533, 3183], '4745-4750Crossref': [2534, 3184], 'If': [2838], 'Importantly,': [3132], 'mostly': [3196], 'post-translational': [3200, 3226, 3941], 'level,': [3201], 'although': [3202], 'mechanisms': [3203], 'mRNA': [3209], 'translation': [3210], 'described': [3213], '[19Kuschel': [3214], 'al.Functional': [3217], 'normoxia--is': [3222], 'regulation?.J.': [3227], '227:': [3231], '514-524Crossref': [3232], 'α-subunits,': [3247], 'coupled': [3248], '(VHL)': [3256], 'E3-ubiquitin': [3257, 3974], 'ligase,': [3258], 'α-subunit': [3263, 3997], 'proteasome.': [3270, 3373, 3654], 'contrast,': [3272], 'increases': [3278], 'absence': [3281], '2).': [3285], 'site': [3292], 'lysosomes': [3296], 'contribute': [3300, 3991], 'certain': [3305], 'circumstances,': [3306], 'chaperone-mediated': [3309], 'autophagy': [3310, 3315], '[20Hubbi': [3311], 'M.E.': [3312], 'al.Chaperone-mediated': [3314], '(HIF-1alpha)': [3319], 'lysosomal': [3321], 'degradation.J.': [3322], '2013;': [3325], '288:': [3326], '10703-10714Crossref': [3327], '(96)': [3330], 'Intriguingly,': [3333], 'mediating': [3335], 'reactions': [3337], 'subject': [3340], '3).Box': [3347], '3Regulation': [3348], 'Hydroxylases': [3351], 'UbiquitylationWhile': [3353], 'itself': [3355, 3636], 'hydroxylases,': [3361, 3642], 'PHD1': [3381, 3513, 3525, 3662, 3795, 3807], 'PHD3': [3383, 3664], 'controlled': [3385, 3666], 'absentia': [3390, 3671], 'homolog': [3391, 3672], '(SIAH1/2)': [3392, 3673], 'ligases;': [3394, 3675], 'no': [3395, 3676], 'regulating': [3398, 3679], 'PHD2': [3399, 3680], 'identified': [3403, 3684], 'yet.': [3404, 3685], 'Interestingly,': [3405, 3686], 'induced': [3407, 3688], 'SIAH1/2': [3408, 3689], 'result': [3412, 3693], 'PHD1/3': [3413, 3694], 'were': [3414, 3561, 3695, 3844], 'reduced': [3415, 3696], '[98Nakayama': [3419, 3700], 'K.': [3420, 3701], 'Ronai': [3421, 3702], 'Z.': [3422, 3703], 'Siah:': [3423, 3704], 'players': [3425, 3706], 'Cycle.': [3432, 3713], '2004;': [3433, 3714], '1345-1347Crossref': [3435, 3716], 'SIAH1': [3439, 3720], 'could': [3440, 3527, 3721, 3809], 'mediate': [3442, 3723], 'pathway': [3448, 3729], 'conditions': [3451, 3732], '[99Fukuba': [3452, 3733], 'H.': [3453, 3734, 4034], 'al.Abundance': [3455, 3736], 'aspargynyl-hydroxylase': [3457, 3738], 'Siah-1': [3462, 3743], 'conditions.433.': [3465, 3746], '2008:': [3466, 3747], '209-214Google': [3467, 3748], 'Altogether,': [3469, 3750], 'SIAH': [3470, 3751], 'part': [3477, 3758], 'being': [3482, 3763], 'able': [3483, 3764], 'hydroxylases:': [3490, 3771], 'FIH.In': [3493], 'addition': [3494, 3776, 3918], 'SIAH1/2,': [3496, 3778], 'Cullin': [3498, 3780], '3': [3499, 3781], 'speckle-type': [3501, 3783], 'POZ': [3502, 3784], '(SPOP)': [3504, 3786], 'was': [3509, 3593, 3791, 3876], 'Lack': [3519, 3801], 'SPOP': [3521, 3540, 3803, 3822], 'subsequently': [3523, 3805], 'linked': [3530, 3812], 'prostate': [3532, 3549, 3814, 3831], 'progression': [3534, 3816], '[100Zhang': [3535, 3817], 'L.': [3536, 3818], 'al.Tumor': [3538, 3820], 'ubiquitinates': [3541, 3823], 'degrades': [3543, 3825], 'EglN2': [3544, 3826], 'compromise': [3546, 3828], 'Lett.': [3552, 3834], '390:': [3554, 3836], '11-20Crossref': [3555, 3837], 'Scholar].Conversely,': [3558], 'ligases.': [3567, 3850], 'particular,': [3569, 3852], 'ankyrin': [3571, 3854], 'repeat': [3572, 3855], 'SOCS': [3574, 3857], 'box': [3575, 3858], '4': [3577, 3860], '(ASB4),': [3578, 3861], 'serves': [3580, 3863], 'substrate-recognizing': [3583, 3866], 'SCF-like': [3587, 3870], 'Elongin-Cullin-SOCS-box': [3588, 3871], 'complex,': [3592, 3875], 'found': [3594, 3877], 'FIH,': [3599, 3882], 'resulting': [3600, 3883], 'vascular': [3603, 3618, 3886, 3901], 'differentiation': [3604, 3619, 3887, 3902], '[101Ferguson': [3605, 3888], 'III,': [3606, 3889], 'J.E.': [3607, 3890], 'al.ASB4': [3609, 3892], 'mechanism.Mol.': [3623, 3906], '6407-6419Crossref': [3628, 3911], 'FIH.': [3774], 'hydroxylation)-independent': [3938], 'manner.': [3939], 'modifications': [3942], 'phosphorylation,': [3945], 'acetylation,': [3946], 'SUMOylation': [3948], '[21Masoud': [3949], 'G.N.': [3950], 'Li': [3951], 'W.': [3952], 'pathway:': [3954], 'role,': [3955], 'intervention': [3958], 'therapy.Acta': [3961], 'Pharm.': [3962], 'Sin.': [3963], '5:': [3966], '378-389Crossref': [3967], '(197)': [3970], 'recruit': [3973], 'α-subunits.': [3978], 'surprising': [3983], '(Tables': [3999], '2).Table': [4002], '1DUBs': [4003], 'Signaling': [4006], 'CancerDUBs(gene': [4008], 'name)Regulation': [4009], 'hypoxiaInvolvement': [4011], 'regulationInvolvement': [4015], 'cancerRefsUSP1(USP1)↓aIn': [4017], 'vitro.Involved': [4018], 'aplastic': [4020], 'anemia': [4021], 'progressionbIn': [4025], 'vivo.Promotes': [4026], 'breast': [4027, 4094], 'metastasis': [4029], 'KPNA2': [4031, 4091], 'stabilizationbIn': [4032], 'vivo.67Oleksandr': [4033], 'al.IRE-1α': [4036], 'peptidases': [4042], 'U87': [4047], 'glioma': [4048], 'cells.Endoplasm.': [4049], 'Reticul.': [4050], 'Stress': [4051], 'Dis.': [4052], '50-62Google': [4055], '102Das': [4057], 'D.S.': [4058], 'al.Blockade': [4060], 'deubiquitylating': [4062], 'USP1': [4064], 'inhibits': [4065], 'repair': [4067], 'triggers': [4069], 'cells.Clin.': [4074], '4280-4289Crossref': [4079], '(10)': [4082], '103Ma': [4085], 'al.USP1': [4088], 'inhibition': [4089], 'destabilizes': [4090], 'suppresses': [4093], 'metastasis.Oncogene.': [4096], '38:': [4098], '2405-2419Crossref': [4099], '(1)': [4102], 'ScholarUSP7(USP7)Deubiquitylation': [4104], 'HIF-1αaIn': [4106], 'vitro.': [4107]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2979410128', 'counts_by_year': [{'year': 2024, 'cited_by_count': 49}, {'year': 2023, 'cited_by_count': 40}, {'year': 2022, 'cited_by_count': 36}, {'year': 2021, 'cited_by_count': 39}, {'year': 2020, 'cited_by_count': 10}], 'updated_date': '2025-01-03T02:19:44.770889', 'created_date': '2019-10-18'}
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