Comprehensive molecular landscape in patients older than 80 years old diagnosed with acute myeloid leukemia: A study of the French Hauts‐de‐France AML observatory

Name: Work Video:
Duration: 3 min 30 s
Loïc Renaud; Olivier Nibourel; Alice Marceau‐Renaut; Bérengère Gruson; Nathalie Cambier; Pauline Lionne‐Huyghe; Bachra Choufi; Céline Rodriguez; Cécile Frimat; Isabelle Plantier; Laure Stalnikiewicz; Maxime Bemba; Céline Berthon; Jean‐Pierre Marolleau; Bruno Quesnel; Claude Preudhomme; Nicolas Duployez
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'number': [402, 651], 'per': [406, 1591], 'patient': [407, 927, 1319, 1581], '3': [409, 899, 1657], '0-7).': [411], 'When': [412, 987], 'grouped': [413, 1568], 'into': [414], 'functional': [415, 1509], 'categories': [416], 'methods),': [419], 'common': [422, 464, 1014], 'class': [423], 'involved': [426, 630, 1553], 'that': [428, 619, 894, 941, 1053, 1189], 'control': [429], 'DNA': [430, 601, 632, 1555], 'methylation': [431, 602, 633, 1556], '(TET2,': [432, 1557], 'DNMT3A,': [433, 1558], 'IDH1,': [434, 1559], 'IDH2)': [436, 1560], '73%': [438], 'cohort.': [441], 'Importantly,': [442], 'least': [450, 503, 594, 689, 1134, 1191, 1459], '25%': [451], 'TET2': [457, 545, 738, 772, 1145], 'being': [459], 'by': [460, 470, 871, 1219, 1382, 1419, 1638, 1749], 'far': [461], 'event': [465], '(43%': [466], 'patients)': [468], 'followed': [469], 'SRSF2': [471, 776], '(27%),': [472], 'DNMT3A': [473, 883, 912, 923, 1055, 1070, 1082, 1120, 1698], '(26%),': [474], 'ASXL1': [476, 559, 780], '(25%)': [478], '(Figure': [479], '1': [480, 504], 'Supporting': [482], 'them': [488, 511], 'have': [489, 647, 823, 1187], 'been': [490, 824], 'previously': [491], 'reported': [492, 825, 1637, 1644], 'age-related': [494, 829, 1047], 'clonal': [495, 830, 1048], 'hematopoiesis.1': [496], 'Overall,': [497], '67': [498], '(76%)': [500], 'harbored': [501], 'large': [508, 667, 1649], '(35': [512], '67)': [514], '2': [516, 727, 908, 1069], 'more': [518, 562, 1001, 1031, 1087, 1200], 'set': [522], 'genes.': [525], 'No': [526], 'systematic': [527], 'precedence': [528], 'between': [529, 906], 'these': [530, 1113], 'events': [531, 577, 1041], 'observed': [533, 549, 895, 942], 'when': [534, 837], 'considering': [535, 1268], 'respective': [537], 'Variant': [538], 'allele': [539], 'frequencies': [540, 1440, 1621, 1677], '(VAFs).': [541], 'Among': [542], 'these,': [543], 'preferentially': [548], '.001)': [557], 'frequent': [563, 576, 858], 'de': [565, 843, 1442, 1691], 'novo': [566, 844, 1443, 1692], '.034)': [570], 'S3).': [574, 641], 'Other': [575], 'included': [578, 1681], 'RUNX1': [579, 784, 821], '(24%),': [580], 'NPM1': [581, 591, 620, 854, 1601], '(19%),': [582], 'TP53': [584, 788], '(17%).': [586], 'cases': [588, 611], 'mutant': [590], 'concomitant': [596], 'controlling': [600], '7': [604, 1494], '(41%)': [605], 'FLT3-ITD': [607], 'positive.': [608], 'In': [609, 706, 852], 'those': [610, 996, 1023], 'VAFs': [615, 1416, 1549, 1575], 'supported': [616], 'fact': [618], 'acquired': [623], 'founding': [625], 'clones': [626], 'bearing': [627], 'virtually': [635], 'all': [636, 1324, 1383, 1615, 1679], 'TP53-mutant': [642], 'shown': [645, 1188, 1463], 'significant': [649, 1004], 'lower': [650], 'compared': [654, 988, 1059, 1631], 'other': [656, 1025, 1247], 'genomic': [657, 676, 757], 'subgroups': [658], '.016)': [661], 'S4).': [665], '(43%)': [671], 'belonged': [672], 'subgroup': [677], 'termed': [678], '"chromatin': [680], 'RNA': [682, 1282], 'splicing': [683, 1283], 'mutations"': [684, 1010], 'requiring': [685], 'presence': [687], 'RUNX1,': [693], 'ASXL1,': [694], 'BCOR,': [695], 'STAG2,': [696], 'EZH2,': [697], 'SRSF2,': [698], 'SF3B1,': [699], 'U2AF1,': [700], 'ZRSR2,': [701], 'KMT2A-PTD,': [703], 'frequently': [704], 'co-occurring.2': [705], 'contrast,': [707, 853], 'biallelic': [710], 'CEBPA': [711], '(CEBPA-dm)': [713], 'IDH2-R172': [717], 'extremely': [720], 'rare': [721], 'population': [724, 984], '(1': [725], 'patients,': [728, 762, 995, 1287], 'respectively).': [729], 'Finally,': [730, 1147], '8': [731], '(9%)': [733], 'driver': [735], '(mostly': [737], 'DNMT3A)': [740], 'without': [741], 'any': [742, 1745], 'class-defining': [743], 'lesions.2': [744], 'By': [745], 'comparison': [746, 872], 'recently': [748], 'published': [749], 'data': [750, 764, 841, 1345], 'Papaemmanuil': [752, 1639, 1719], 'et': [753, 1640, 1720, 1730], 'al.2': [754], 'reporting': [755], 'profiling': [758], 'our': [763, 840, 886, 935, 1683], 'highlight': [765], 'enrichment': [768, 1005], '<': [774, 778, 782, 786, 802], '.001),': [775, 779, 783, 787, 791, 795, 803], 'CBL': [792, 1567], 'BCOR': [796], '.002),': [799], 'JAK2': [800, 850], 'SF3B1': [805], '.011)': [808], 'S5).': [818], 'occur': [827, 1034], 'hematopoiesis': [831], 'CHIP.': [833, 1018], 'same': [835, 867], 'applies': [836], 'we': [838, 1051, 1149], 'focus': [839], 'exception': [848], 'mutations.': [851, 1146], 'appear': [856, 890], 'less': [857], '.036).': [865], 'TCGA.3': [879], 'rate': [881, 938], 'does': [888], 'statistically': [891], 'patients2,': [898], 'pattern': [902], 'differs': [905], 'subgroups.': [909], 'Indeed,': [910, 1184], 'involving': [914, 1274, 1700], 'R882': [916, 1702], 'codon': [917, 1703], 'account': [918], '60%': [921], '<60-years': [928], 'old2,': [929], 'it': [930], 'represents': [931], 'cohort:': [936], 'comparable': [939], 'CHIP1': [946], 'S6).': [950], 'disease': [954, 978], 'However,': [959], 'underrepresented': [963], 'often': [965], 'excluded': [966], 'current': [968], 'trials': [970], 'studies': [972, 991, 1186, 1209], 'basis': [975], 'lacking': [980], 'aged': [997, 1661], '80': [998], 'years': [999], 'show': [1002, 1507], 'well': [1007], 'named': [1008], '"age-related': [1009], 'also': [1013, 1331], 'individuals': [1016, 1725], 'Considering': [1019], 'there': [1020], 'results': [1021, 1114], 'groups,4,': [1026], '5': [1027, 1111, 1460], 'likely': [1032], 'through': [1035], 'acquisition': [1037], 'context': [1044], 'prior': [1046], 'hematopoiesis.': [1049], 'Additionally,': [1050], 'showed': [1052], 'nonR882': [1054, 1121, 1705], 'overrepresented': [1058], '(85%': [1064], 'vs': [1065, 1445, 1704], '≈40%)': [1066], 'possibly': [1067], 'reflecting': [1068], 'mutational': [1071], 'patterns': [1072], 'risk': [1075, 1125], 'time': [1077, 1137], 'progression.': [1079], 'Moreover,': [1080], 'CHIP,1': [1094], 'they': [1095], 'quarter': [1100], 'third': [1103], 'old.4,': [1110], 'Together,': [1112], 'suggest': [1115], 'role': [1118], 'progression': [1127, 1139], 'CHIP': [1129, 1727], 'longer': [1136], 'preleukemic': [1142], 'DNMT3A-R882': [1143], 'although': [1148], 'able': [1152], 'evaluate': [1154], 'impact': [1156], 'treatment,': [1158], 'description': [1161], 'needed': [1170, 1211], 'improve': [1172, 1223], 'management': [1173], 'population,': [1176], 'curative': [1179], 'treatment': [1180, 1474], 'currently': [1182], 'available.': [1183], 'some': [1185], 'subset': [1193], 'could': [1197, 1222], 'benefit': [1198], 'regimens,': [1202], 'even': [1203, 1233], 'octogenarian': [1205], 'patients.4,': [1206], '6': [1207], 'Further': [1208], 'assess': [1213], 'whether': [1214], 'approach': [1217], 'guided': [1218], 'Low': [1229], 'chemotherapy': [1235], 'should': [1236, 1758], 'be': [1237, 1295, 1759], 'preferable': [1238], 'fit': [1240], 'NPM1-mutated': [1243], 'On': [1245], 'hand,': [1248], 'hypomethylating': [1249], 'now': [1252], 'widely': [1253], 'remain': [1260], 'good': [1262], 'option': [1263], 'interesting': [1265], 'results.': [1266], 'Lastly,': [1267], 'high': [1270], 'frequency': [1271], 'TP53,': [1275], 'IDH1/2': [1276], 'encoding': [1280], 'machinery': [1284], 'such': [1286], 'targeted': [1288], 'therapies': [1289], 'development': [1293], 'may': [1294], 'promising.': [1296], 'authors': [1298], 'thank': [1299], 'Christophe': [1300], 'Roumier': [1301], 'Tumor': [1304], 'Bank': [1305], 'Lille': [1308], 'University': [1309], 'Hospital': [1310], '(certification': [1311], 'NF': [1312], '96900-2014/65453-1)': [1313], 'handling,': [1315], 'conditioning,': [1316], 'storing': [1318], 'samples.': [1320], 'work': [1322], 'physicians': [1325], 'research': [1328], 'assistants': [1329], 'acknowledged.': [1332], 'CP,': [1333, 1350, 1373], 'ON,': [1334, 1340, 1348], 'ND': [1336, 1352, 1375], 'designed': [1337], 'study.': [1339, 1684], 'CR,': [1341], 'CF': [1343], 'ensured': [1344], 'management.': [1346], 'LR,': [1347, 1372], 'AMR,': [1349], 'performed': [1353, 1431], 'analyses.': [1355], 'BG,': [1356], 'NC,': [1357], 'PL,': [1358], 'BC,': [1359], 'IP,': [1360], 'LS,': [1361], 'MB,': [1362], 'CB,': [1363], 'JPM,': [1364], 'BQ': [1366], 'enrolled': [1367, 1655], 'provided': [1370], 'materials.': [1371], 'wrote': [1376], 'article': [1378], 'approved': [1381], 'authors.': [1385, 1751], 'Nothing': [1386], 'report.': [1388], 'TABLE': [1389, 1401, 1436], 'S1': [1390, 1466], 'Characteristics': [1391], 'S2': [1402, 1487], 'Identified': [1403], 'variants': [1404, 1426, 1491], 'old.': [1415, 1453, 1504], 'given': [1418], 'HTS.': [1420], 'prediction': [1422], 'single': [1424], 'nucleotide': [1425], 'protein': [1428, 1510], 'function': [1429], 'SIFT4': [1433], 'Polyphen-25': [1435], 'S3': [1437, 1536], 'Gene': [1438, 1619], 'here': [1464], 'FIGURE': [1465, 1486, 1535, 1585, 1617, 1694], 'Kaplan-Meier': [1467], 'curves': [1468], 'showing': [1469, 1545, 1573], '301)': [1485], 'Distribution': [1488], 'identified': [1490], 'Colored': [1505], 'boxes': [1506], 'putative': [1508], 'domains': [1511], '(mutation': [1512], 'diagrams': [1513], 'done': [1515], 'online': [1518], 'MutationMapper': [1519], 'tool:': [1520], 'http://www.cbioportal.org).': [1521], 'Black,': [1522], 'green': [1523], 'brown': [1525], 'dots': [1526], 'indicate': [1527], 'frameshift/nonsense,': [1528], 'missense': [1529], 'frame': [1532], 'mutations,': [1533], 'respectively': [1534], 'Coexisting': [1537], 'NPM1-mutant': [1540, 1583], 'A,': [1542], 'Box': [1543], 'plot': [1544, 1572], 'distribution': [1547], 'signaling': [1562], '(NRAS,': [1563], 'KRAS,': [1564], 'FLT3,': [1565], 'PTPN11,': [1566], 'together).': [1569], 'B,': [1570], 'Dot': [1571], 'S4': [1586], 'Number': [1587], 'T53': [1596], '(A),': [1598], '(B),': [1603], 'chromatin': [1607], 'RNA-splicing': [1609], '(C)': [1611, 1723], 'S5': [1618], '(pink': [1629], 'color)': [1630, 1636], '(blue': [1635], 'al7:': [1641], 'sequencing': [1646], '1540': [1652], 'prospective': [1658], 'trials,': [1659], 'mostly': [1660], '18-': [1663], '60-years': [1665, 1672], '(only': [1667], '11%': [1668], 'old).': [1673], 'Panel': [1674, 1685], 'shows': [1676], 'B': [1686], 'restricted': [1688], 'S6': [1695], 'Proportion': [1696], '(A)': [1710], 'study,': [1712], '(B)': [1713], 'al.,7': [1721], 'Jaiswal': [1729], 'al.8': [1731], 'Please': [1732], 'note:': [1733], 'publisher': [1735], 'responsible': [1738], 'content': [1741], 'functionality': [1743], 'supporting': [1746], 'information': [1747], 'supplied': [1748], 'Any': [1752], 'queries': [1753], '(other': [1754], 'missing': [1756], 'content)': [1757], 'directed': [1760], 'corresponding': [1763], 'author': [1764], 'article.': [1767]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2977631319', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2025-01-12T14:08:42.293322', 'created_date': '2019-10-10'}
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