Apicomplexan F‐actin is required for efficient nuclear entry during host cell invasion

Name: Work Video:
Duration: 3 min 30 s
Mario Del Rosario; Javier Periz; Georgios Pavlou; Oliver Lyth; María Fernanda Latorre Barragán; Sujaan Das; Gurman S. Pall; Johannes Felix Stortz; Leandro Lemgruber; Jamie Whitelaw; Jake Baum; Isabelle Tardieux; Markus Meissner
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'and': [158, 551, 835, 886, 926, 944, 966, 1033, 1060, 1074, 1077, 1100, 1122, 1162, 1201, 1215, 1231, 1234, 1260, 1284, 1287, 1310, 1328, 1370, 1388, 1465, 1477, 1489, 1501, 1519, 1538, 1549, 1653, 1677, 1702, 1770, 1812, 1862, 1894, 1901, 1918, 1944, 2025, 2054, 2083, 2108, 2128, 2139, 2146, 2251, 2316, 2382, 2473, 2506, 2511, 2522, 2536, 2546, 2562, 2575, 2604, 2626, 2638, 2673, 2687, 2704, 2766, 2777, 2803, 2828, 2871, 2889, 2972, 3012, 3046, 3103, 3158, 3187, 3221, 3244, 3305, 3310, 3351, 3392, 3490, 3520, 3552, 3570, 3625, 3669, 3681, 3692, 3699, 3713, 3738, 3760, 3811, 3849, 3875, 3894, 3897, 3916, 3963, 4034, 4060, 4070, 4087, 4182, 4197, 4266], 'Biotechnology,': [159, 552, 887], 'Technical': [160, 553, 888], 'Ambato,': [163, 164, 556, 557, 891, 892], 'Ecuador': [165, 558, 893], 'Sujaan': [173, 175, 566, 568, 818], 'Das': [174, 176, 567, 569], 'Gurman': [204, 207, 597, 600, 820], 'S': [205, 208, 598, 601, 821], 'Pall': [206, 209, 599, 602], 'Johannes': [237, 240, 630, 633, 823], 'Felix': [238, 241, 631, 634, 824], 'Stortz': [239, 242, 632, 635], 'orcid.org/0000-0002-5928-1850': [243, 636], 'Leandro': [271, 273, 664, 666, 826], 'Lemgruber': [272, 274, 665, 667], 'Jamie': [302, 305, 695, 698, 828], 'A': [303, 306, 696, 699, 829, 2475, 2794, 3534], 'Whitelaw': [304, 307, 697, 700], 'CRUK': [308, 701], 'Beatson': [309, 702, 895], 'Institute,': [310, 703, 896], 'Jake': [320, 322, 713, 715, 831], 'Baum': [321, 323, 714, 716], 'orcid.org/0000-0002-0275-352X': [324, 717], 'Isabelle': [341, 343, 734, 736, 833], 'Tardieux': [342, 344, 735, 737], 'orcid.org/0000-0002-5677-7463': [345, 738], 'Markus': [366, 370, 759, 763, 836], 'Meissner': [367, 371, 760, 764, 837], 'Corresponding': [368, 761], 'Author': [369, 762, 805], '[email': [372, 765, 916], 'protected]': [373, 766, 917], 'orcid.org/0000-0002-4816-5221': [374, 767], 'Experimental': [395, 788], 'Veterinary': [399, 792, 903], 'Ludwig-Maximilians-University': [401, 794, 905], 'Munich,': [402, 403, 795, 796, 906, 907], 'Germany': [404, 797, 908], 'Information': [806], 'Rosario1,': [809], 'Periz1,': [811], 'Pavlou2,': [813], 'Lyth3,': [815], 'Latorre-Barragan1,4,': [817], 'Das1,': [819], 'Pall1,': [822], 'Stortz1,': [825], 'Lemgruber1,': [827], 'Whitelaw5,': [830], 'Baum3,': [832], 'Tardieux2': [834], '*,1,6': [838], '1Wellcome': [839], '2Institute': [859], '3Department': [872], '4Faculty': [881], '5CRUK': [894], '6Experimental': [899], '*Corresponding': [909], 'author.': [910], 'Tel:': [911], '+49': [912], '89': [913], '21803622;': [914], 'E-mail:': [915], 'EMBO': [918], 'Reports': [919], '(2019)20:e48896https://doi.org/10.15252/embr.201948896': [920], 'PDFDownload': [921], 'PDF': [922], 'article': [924], 'text': [925], 'main': [927], 'figures.': [928], 'Peer': [929], 'ReviewDownload': [930], 'a': [931, 974, 993, 1004, 1010, 1128, 1146, 1170, 1186, 1209, 1301, 1343, 1418, 1570, 1642, 1695, 1764, 2013, 2062, 2119, 2179, 2199, 2230, 2263, 2285, 2318, 2669, 2739, 2789, 2804, 2990, 3096, 3129, 3138, 3166, 3468, 3477, 3745, 3784, 3789, 3987, 4062, 4098, 4148, 4162], 'summary': [932], 'the': [934, 978, 981, 986, 990, 1001, 1019, 1041, 1050, 1085, 1090, 1098, 1102, 1105, 1111, 1116, 1119, 1124, 1155, 1159, 1163, 1198, 1202, 1213, 1216, 1221, 1239, 1295, 1311, 1315, 1319, 1325, 1329, 1338, 1349, 1354, 1362, 1374, 1382, 1392, 1395, 1399, 1403, 1410, 1415, 1429, 1440, 1450, 1459, 1462, 1468, 1493, 1511, 1514, 1527, 1531, 1534, 1541, 1547, 1552, 1560, 1581, 1593, 1598, 1604, 1619, 1626, 1659, 1682, 1713, 1734, 1738, 1744, 1752, 1768, 1778, 1799, 1827, 1851, 1857, 1866, 1872, 1889, 1909, 1913, 1935, 1955, 1963, 1967, 1974, 1977, 1980, 1984, 1993, 2002, 2005, 2009, 2020, 2023, 2027, 2030, 2048, 2051, 2076, 2085, 2095, 2106, 2113, 2126, 2129, 2143, 2152, 2173, 2210, 2221, 2227, 2244, 2254, 2276, 2344, 2360, 2385, 2402, 2411, 2467, 2485, 2488, 2501, 2533, 2540, 2550, 2554, 2570, 2573, 2580, 2590, 2623, 2629, 2633, 2649, 2659, 2662, 2683, 2689, 2694, 2701, 2712, 2730, 2754, 2757, 2762, 2796, 2800, 2808, 2848, 2855, 2858, 2866, 2885, 2901, 2913, 2919, 2926, 2930, 2995, 2998, 3025, 3029, 3033, 3037, 3052, 3060, 3064, 3068, 3107, 3112, 3118, 3122, 3142, 3169, 3172, 3199, 3202, 3206, 3209, 3212, 3229, 3271, 3283, 3287, 3295, 3329, 3337, 3341, 3385, 3404, 3418, 3434, 3449, 3452, 3457, 3481, 3529, 3596, 3601, 3623, 3639, 3647, 3650, 3664, 3676, 3679, 3683, 3687, 3720, 3742, 3755, 3764, 3770, 3773, 3822, 3836, 3863, 3873, 3882, 3887, 3901, 3904, 3914, 3920, 3923, 3945, 3948, 3957, 3974, 3981, 3993, 4004, 4016, 4031, 4037, 4041, 4055, 4058, 4068, 4074, 4084, 4095, 4116, 4121, 4134, 4174, 4192, 4201, 4220, 4227, 4235, 4239, 4243, 4257, 4264, 4270], 'editorial': [935, 939], 'decision': [936, 940], 'including': [938, 1257], 'letters,': [941], 'reviewer': [942], 'comments': [943], 'responses': [946], 'to': [947, 950, 1007, 1115, 1151, 1281, 1288, 1373, 1428, 1456, 1510, 1580, 1758, 1789, 1798, 1837, 1856, 1865, 1871, 1904, 1983, 1999, 2008, 2019, 2029, 2050, 2072, 2082, 2100, 2112, 2169, 2185, 2225, 2240, 2249, 2275, 2297, 2314, 2371, 2384, 2397, 2482, 2525, 2539, 2549, 2569, 2597, 2614, 2628, 2679, 2774, 2875, 2912, 2918, 2925, 3028, 3136, 3201, 3475, 3619, 3636, 3696, 3730, 3829, 3842, 3886, 3936, 4013, 4103, 4188, 4214, 4242, 4256], 'feedback.': [948], 'ToolsAdd': [949], 'favoritesDownload': [951], 'CitationsTrack': [952], 'CitationsPermissions': [953], 'ShareFacebookTwitterLinked': [954], 'InMendeleyWechatReddit': [955], 'Figures': [956], 'Info': [958], 'Abstract': [959], 'The': [960, 1242, 1357, 1423, 2192, 3072, 3126, 3146, 3160, 3177, 3191, 3252, 3370, 3465, 3498, 3629, 3852], 'obligate': [961, 1254], 'intracellular': [962, 1255, 1832, 1910, 1925, 1991, 2189, 2520, 2581, 2610, 2645, 2655, 2702, 2841, 2876, 4014], 'parasites': [963, 1002, 1065, 1144, 1224, 1276, 1451, 1609, 1691, 1706, 1795, 1833, 2141, 2167, 2190, 2386, 2505, 2521, 2656, 2783, 2842, 2877, 2953, 3015, 3253, 3301, 3347, 3395, 3499, 3519, 3524, 3538, 3715, 3995, 4023, 4119, 4132], 'Toxoplasma': [964, 1268, 2561], 'gondii': [965, 1811, 1898, 2746, 3780], 'Plasmodium': [967, 1265, 2563], 'spp.': [968], 'invade': [969, 1289], 'cells': [971, 988], 'injecting': [973], 'protein': [975, 1406, 1635, 2413, 2732], 'complex': [976, 1272, 1332, 1421], 'into': [977, 1381, 3612, 3821], 'membrane': [979, 1327, 1331, 1386, 1576], 'targeted': [982], 'that': [984, 1012, 1089, 1110, 1149, 1183, 1219, 1559, 1573, 1725, 1958, 1969, 2042, 2079, 2118, 2238, 2367, 2393, 2423, 2436, 2565, 2636, 2753, 2768, 2847, 3100, 3615, 3659, 3710, 3753, 3787, 4011, 4048, 4066, 4094, 4115, 4286], 'bridges': [985], 'two': [987, 1355, 1819, 2527, 2618, 2830, 2891, 2985, 4025], 'through': [989, 1084, 1104, 1154, 1238, 1278, 1439, 1458, 1681, 2243, 2256, 2284], 'assembly': [991], 'ring-like': [994], 'junction.': [995, 1086, 1240], 'This': [996, 1167, 3214, 3656, 3815, 4184], 'circular': [997], 'junction': [998, 1051, 1099, 1112, 1214, 1605, 2245, 2346], 'stretches': [999], 'while': [1000, 1927, 2585, 3063, 3117, 3225, 3286, 3428, 3976, 4145], 'apply': [1003], 'traction': [1005], 'force': [1006, 1515], 'pass': [1008, 1457], 'through,': [1009], 'step': [1011], 'typically': [1013, 2725], 'concurs': [1014], 'with': [1015, 1066, 1225, 1729, 1760, 1888, 2061, 2075, 2094, 2151, 2172, 2664, 2727, 2734, 2860, 2884, 3241, 3257, 3308, 3354, 3398, 3409, 3493, 3525, 3600, 3769, 3966, 3980, 4120, 4216, 4230, 4260], 'transient': [1016, 2684, 2722], 'constriction': [1017], 'parasite': [1020, 1164, 1411, 1532, 1553, 1561, 1601, 1914, 1968, 2006, 2024, 2070, 2124, 2218, 2293, 2322, 2365, 2464, 2492, 2555, 2574, 2602, 2646, 2663, 2764, 2859, 2931, 2974, 2999, 3207, 3453, 3660, 3680, 3949, 4240], 'body.': [1021], 'Here': [1022, 2132], 'we': [1023, 2133, 2352, 2363, 2428, 2462, 2743, 2824, 3603, 3932, 4113], 'analyse': [1024, 1790, 2298, 3731], 'dynamics': [1026, 1792, 1997, 2136, 2216, 2248, 2277, 2300, 2358, 2435, 2653, 2698, 2827, 2852, 2950, 3143, 3482, 3626, 3644, 3927, 3955, 3991], 'invasion.': [1030, 1166, 1206, 1637, 1776, 2158, 2328, 2605], 'Super-resolution': [1031, 1179], 'microscopy': [1032, 1180, 2822], 'real-time': [1034], 'imaging': [1035, 1181], 'highlighted': [1036], 'an': [1037, 1046, 1499, 1612, 1921], 'pool': [1039], 'at': [1040, 1049, 1197, 1348, 1526, 1850, 1962, 1988, 2209, 2532, 2589, 2617, 2622, 2688, 2865, 2969, 2984, 3282, 3294, 3403, 3417, 3448, 3663, 3913, 4030, 4036, 4263], 'apex': [1042], 'pre-invading': [1044], 'parasite,': [1045, 2634, 3765, 3921, 4075, 4271], 'ring': [1048, 1157, 1204, 1218, 1346], 'area': [1052, 3759], 'but': [1055, 2375], 'also': [1056, 1563, 2429, 2879, 3255], 'networks': [1057, 1804], 'perinuclear': [1059, 1075, 1232], 'posteriorly': [1061], 'localised': [1062, 1317, 2568, 2588, 2621], 'F-actin.': [1063, 1617, 3145, 3484, 3628], 'Mutant': [1064, 1223], 'dysfunctional': [1067, 1226], 'acto-myosin': [1068, 1227, 1313, 1454, 1470, 2144, 2222, 2387], 'showed': [1069], 'significant': [1070, 2735, 2944], 'decrease': [1071], 'junctional': [1073, 1156, 1203, 1230, 1345, 1420], 'are': [1078, 2080, 2640, 2724, 3578, 3839], 'coincidently': [1079], 'affected': [1080, 2324, 2333], 'in': [1081, 1191, 1318, 1414, 1496, 1647, 1664, 1689, 1704, 1793, 1808, 1831, 1896, 1924, 1934, 1990, 2104, 2137, 2160, 2165, 2178, 2198, 2206, 2217, 2273, 2295, 2325, 2334, 2355, 2378, 2401, 2433, 2441, 2453, 2519, 2609, 2654, 2668, 2718, 2786, 2840, 2854, 2869, 2909, 2943, 2951, 3007, 3077, 3151, 3168, 3219, 3228, 3328, 3336, 3362, 3375, 3382, 3433, 3750, 3766, 3778, 3835, 3857, 3869, 3928, 3944, 4007, 4021, 4130, 4133, 4172, 4191, 4234], 'passage': [1083, 1095, 1117, 1237], 'We': [1087, 1816, 2389, 2514, 2676, 2751, 2780], 'propose': [1088], 'machinery': [1092, 1175], 'eases': [1093, 1176], 'stabilising': [1097, 2105], 'pushing': [1101], 'nucleus': [1103, 1121, 1627, 2228, 2255], 'constriction.': [1106], 'Our': [1107, 2259], 'analysis': [1108, 2260, 2845, 3155, 3551, 3657, 3727, 3935, 4046], 'suggests': [1109, 1629, 2262], 'opposes': [1113], 'resistance': [1114], "parasite's": [1120, 1469, 1867, 2010, 3173], 'provides': [1123], 'first': [1125, 4236], 'evidence': [1126], 'dual': [1129], 'contribution': [1130, 2486], 'actin-forces': [1132], 'apicomplexan': [1138, 1143, 1275, 1616, 1705, 1794], 'parasites.': [1139, 1193], 'Synopsis': [1140], 'Nuclei': [1141], 'represent': [1145, 3128, 3467, 3562, 3573], 'major': [1147, 1643, 2231, 2528, 2986, 4026], 'obstacle': [1148, 2232], 'needs': [1150, 2239], 'be': [1152, 1848, 2073, 2170, 2241, 2332, 2372, 2398, 2421, 2425, 2598, 2615, 2895, 3022, 3042, 3280, 3366, 3422, 3617, 3634, 3697, 3819, 3855, 3911, 4189], 'squeezed': [1153, 2242], 'bridging': [1158], 'study': [1168], 'proposes': [1169], 'push-and-pull': [1171, 2264], 'mechanism': [1172, 2265, 4185], 'whereby': [1173], 'passage.': [1178], 'reveals': [1182], 'forms': [1185, 1208, 2989], 'highly': [1187, 4019, 4063], 'dynamic,': [1188, 2991], 'cytosolic': [1189, 1622, 1803, 2063, 3215, 3751], 'network': [1190, 1211, 1923, 2993, 3099, 3749, 4065, 4081], 'extracellular': [1192, 1393, 2166, 2504, 2685, 3008, 4022], 'independently': [1195, 3703, 4077, 4272], 'accumulates': [1196], 'posterior': [1199, 1217, 1985, 2052, 2211, 2551, 2927, 2973, 3034, 3104, 3203], 'pole': [1200, 2032, 2053, 2928, 3035, 3105, 3204, 3685, 3762, 3884, 3918, 4072, 4268], 'continuous': [1210, 2014, 2992, 3194, 3746], 'between': [1212, 1285, 1324, 1353, 1546, 2123, 2761, 3044, 3961, 4083], 'surrounds': [1220], 'nucleus.': [1222], 'exhibits': [1228], 'decreased': [1229], 'reduced': [1235], 'Introduction': [1241], 'phylum': [1243], 'Apicomplexa': [1244, 1649], 'consists': [1245], 'than': [1248], '5,000': [1249], 'species,': [1250], 'most': [1251, 1825, 2578], 'them': [1253], 'parasites,': [1256, 1926, 1992, 2162, 2611, 2788, 3224, 4015], 'important': [1258, 2102], 'human': [1259], 'veterinary': [1261], 'pathogens,': [1262], 'such': [1263, 1568, 1668, 1746, 2338, 2406, 2445, 2457, 4179], 'as': [1264, 1569, 1669, 1747, 2229, 2339, 2407, 2446, 2458, 2642, 2837, 3807, 3862, 3971, 4180], '(malaria)': [1266], 'or': [1267, 1751, 2347, 2410, 2449, 2714, 2949, 3249, 3263, 3315, 3333, 3357, 3389, 3496, 3509, 3531, 3804, 4218, 4275], '(toxoplasmosis).': [1269], 'During': [1270, 1446], 'their': [1271, 1290, 1453], 'life': [1273, 2686], 'cycles,': [1274], 'move': [1277], 'different': [1279, 2763], 'environments': [1280], 'disseminate': [1282], 'within': [1283, 1540, 1979, 2001, 2500, 2658, 2994, 3208, 3675, 4226], 'hosts': [1286], '1.': [1293, 2981], 'Therefore,': [1294, 2461], 'invasive': [1296, 1490], 'stages,': [1297], 'called': [1298], 'zoites,': [1299], 'evolved': [1300], 'unique': [1302, 1307, 1366], 'device,': [1304], 'consisting': [1305], 'secretory': [1308, 1367], 'organelles': [1309, 1368], 'parasites’': [1312], 'system,': [1314, 2066], 'Glideosome,': [1316, 1745], 'narrow': [1320, 1542], 'space': [1321, 1543, 1982], '(~30': [1322, 1544], 'nm)': [1323, 1545], 'plasma': [1326, 1385], 'inner': [1330], '(IMC)': [1333], '2.': [1334], 'Zoites': [1335], 'actively': [1336], 'enter': [1337], 'establishing': [1342], 'tight': [1344, 2345], '(TJ)': [1347], 'point': [1350, 3888, 4010], 'contact': [1352], 'cells.': [1356], 'TJ': [1358, 1424], 'assembled': [1360], 'sequential': [1363], 'secretion': [1364, 4196], '(micronemes': [1369], 'rhoptries),': [1371], 'leading': [1372, 1797], 'insertion': [1375], 'rhoptry': [1377], 'neck': [1378], 'proteins': [1379, 1444, 1749, 2090], '(RONs)': [1380], '(PM)': [1387], 'underneath': [1389, 1603], '3.': [1390, 1422], 'On': [1391], 'side,': [1394], 'exposed': [1396, 1408], 'domain': [1397], 'RON2': [1400], 'member': [1401], 'binds': [1402], 'micronemal': [1404, 2412], 'transmembrane': [1405], 'AMA1': [1407], 'on': [1409, 1523, 1840, 2188, 2560, 2738, 3528, 3846], 'surface,': [1412], 'resulting': [1413, 2205, 3630], 'formation': [1416, 1436, 1919, 2342], 'stable,': [1419], 'further': [1426, 1841], 'anchored': [1427], 'cortex': [1432], 'de': [1434], 'novo': [1435], 'recruitment': [1441], 'actin-nucleating': [1443], '45.': [1445], 'invasion,': [1449, 1655, 2272, 2405, 2444, 2456, 2693], 'use': [1452, 1564], 'motor': [1455, 1595, 2798], 'TJ.': [1460], 'However,': [1461, 1555, 1693, 4112], 'exact': [1463], 'role': [1464, 1644, 1661], 'orientation': [1466], 'system': [1471, 1485, 2145, 2223], 'still': [1473], 'under': [1474], 'debate': [1475], '6': [1476], 'intriguingly,': [1478], 'mutants': [1479, 2219, 2294, 2323, 2330, 2366, 2392, 2431, 4211], 'key': [1481], 'component': [1482], 'show': [1486, 3637], 'residual': [1487], 'motile': [1488], 'capacities': [1491], '789,': [1492], 'latter': [1494], 'reflecting': [1495], 'large': [1497], 'part': [1498], 'alternative': [1500], 'actin-dependant': [1504], 'mode': [1505], '10.': [1508, 2494], 'According': [1509], 'Glideosome': [1512, 1978, 2096, 2127, 2713, 2801], 'model,': [1513, 1596], 'generated': [1516, 2744, 3163, 3513], 'motility': [1518, 1566, 1652, 1675, 1943, 2603], 'relies': [1521], 'exclusively': [1522, 1971, 2599], 'polymerised': [1525], 'apical': [1528, 1852, 1936, 1964, 2028, 2049, 2534, 2591, 2624, 2902, 2971, 3026, 3069, 3102, 3123, 3200, 3284, 3314, 3338, 3405, 3419, 3530, 3665, 3756, 3883, 3915, 4032, 4069, 4244, 4265], 'tip': [1529, 1965, 2535, 2625, 2903, 3420, 3666, 4033], 'action': [1535, 1766, 1975], 'Formin-1': [1537, 1928, 2586], 'translocated': [1539], 'IMC': [1548, 1739, 2086, 2107], 'PM': [1550, 4086], '11.': [1554, 1899, 1947, 3781], 'recent': [1556, 1656, 2306, 2558], 'studies': [1557, 1657, 1723, 1842, 2559], 'suggest': [1558, 4285], 'can': [1562, 1847, 2044, 2331, 2420, 2424, 2894, 3021, 3041, 3279, 3365, 3421, 3616, 3633, 3817, 3854], 'other': [1565, 1587, 1666, 2282, 3706], 'systems,': [1567], 'secretory-endocytic': [1571], 'cycle': [1572], 'produces': [1574], 'retrograde': [1575, 2180, 2202, 2870, 4105], 'flow': [1577, 1583, 1829, 2016, 2040, 2164, 2496, 2518, 2666, 2863, 2898, 3003, 3020, 3053, 3694, 3734, 3969, 4052], '12,': [1578], 'similar': [1579, 2184, 2874, 3218, 3397, 3717, 3960], 'fountain': [1582], 'model': [1584, 1697], 'suggested': [1585, 1724, 1957, 4093], 'eukaryotes': [1588, 2283], '1314.': [1589], 'In': [1590, 1877, 1948, 2034, 2058, 2606, 2881, 3439, 3456, 3900, 4250], 'support': [1591], 'linear': [1594], 'was': [1597, 1640, 2759, 3162, 3547, 3728], 'detection': [1599, 1620, 3828], 'formed': [1606, 2545, 2616, 2983, 3662], 'invading': [1608], 'when': [1610], 'using': [1611, 2246, 3736], 'antibody': [1613], 'preferentially': [1614, 3335], 'recognising': [1615, 1783], 'Furthermore,': [1618, 1741, 2088], 'locations,': [1623], 'predominantly': [1624, 4149], 'around': [1625], '15,': [1628], 'additional': [1630], 'roles': [1631, 2103], 'cytoskeletal': [1634], 'While': [1638, 2936, 3312], 'it': [1639, 1785, 2043, 2111, 2594], 'assumed': [1641], 'driving': [1648], 'zoite': [1650], 'gliding': [1651, 1942], 'demonstrated': [1658, 1757, 2041, 2069, 2564, 2846], 'pivotal': [1660], 'multiple': [1665, 3554], 'processes,': [1667], 'apicoplast': [1670, 2571], 'inheritance': [1671], '16,': [1672], 'dense': [1673], 'granule': [1674], '17': [1676], 'likely': [1678], 'functions': [1680, 1907], 'control': [1683], 'expression': [1685, 2755, 2770], 'virulence': [1687], 'genes': [1688], 'malaria': [1690], '18.': [1692], 'building': [1694], 'comprehensive': [1696], 'dynamics,': [1700, 2964], 'localisation': [1701, 2886, 2948, 3364, 3624], 'function': [1703], 'has': [1707, 1930, 2478], 'been': [1708, 1931, 2312, 2395, 2439, 2479], 'hampered': [1709], 'decades': [1711], 'lack': [1714, 3924, 3988], 'tools': [1716], 'enabling': [1717], 'reliable': [1718], 'detection.': [1720], 'Interestingly,': [1721, 1987, 2159, 3689, 3953], 'several': [1722], 'interacting': [1728], 'subpellicular': [1730, 1735, 2077, 2114, 2130], 'microtubules': [1731, 1761, 2078, 2115], '19': [1732], 'and/or': [1733], 'matrix': [1736], '2021.': [1740], 'components': [1742], 'GAPM': [1748], '22': [1750], 'invasion-critical': [1753], 'myosin,': [1754], 'MyoH': [1755, 2408], 'were': [1756, 2097, 2353, 2368, 2523, 2677, 2707, 3254, 3500, 3512, 3539, 4212], 'interact': [1759], '23,': [1762], 'suggesting': [1763, 2117], 'coordinated': [1765], 'actin': [1769, 1807, 2434, 2465, 2468, 2697, 2810, 2812, 2963, 3002, 3278, 3445, 3487, 3526, 3597, 3941, 3954, 3968, 4051], 'microtubule': [1771], 'cytoskeleton': [1772], 'With': [1777], 'adaptation': [1779], 'nanobodies': [1781], 'specifically': [1782], 'F-actin,': [1784, 2125, 2982, 4108], 'now': [1787], 'possible': [1788], '2425': [1796], 'identification': [1800], 'distinct': [1802], 'dynamic': [1806, 2015, 2149, 2583, 2740, 3098, 3747, 3879, 4020, 4064], 'both': [1809, 2970, 3690, 3711, 3847], 'T.': [1810, 1878, 1897, 2745, 3779], 'P.': [1813], 'falciparum': [1814], '112425.': [1815], 'originally': [1817], 'identified': [1818, 2091], 'polymerisation': [1821, 1845, 1882, 1937, 2529, 2619, 2833, 2892, 2905, 2915, 4027], 'centres': [1822, 1883, 2834, 2893], 'from': [1823, 2017, 2026, 2047, 2700, 2900, 3024, 3198, 3704, 4054], 'where': [1824, 2542, 2593, 3086, 3638, 3793], 'occurs': [1830, 2657, 2853, 3327], '24,': [1834, 2742], 'later': [1835], 'expanded': [1836], 'three': [1838, 1881, 3235], 'based': [1839, 3845], '1125.': [1843, 1876], 'One': [1844], 'centre': [1846, 2018, 2916], 'found': [1849, 2099, 2829, 4114], 'tip,': [1853, 2592, 3027, 3285], 'corresponding': [1854, 1870], 'well': [1855, 1887], 'described': [1858, 2396, 3777], 'location': [1859, 1873, 1890, 2150, 3324, 3752, 3771], 'Formin-1,': [1861], 'one': [1863, 2531, 2537, 4029], 'close': [1864, 2007, 2120, 2538, 2627, 2917], 'Golgi': [1868, 2630, 2920, 3030, 3061, 3113, 3670, 3758, 3890, 4038], 'complex,': [1869], 'Formin-2': [1875, 2566], 'gondii,': [1879], 'these': [1880, 3843, 3929, 4283], 'correlate': [1886], 'Formins-1,': [1892], '2': [1893, 3258, 3893], '3': [1895, 1902, 3542, 3774, 3790, 3895], 'Formins-2': [1900], 'appear': [1903, 3695], 'have': [1905, 2311, 2394, 2437], 'overlapping': [1906], 'development': [1911], 'material': [1916], 'exchange': [1917, 3195, 3216], 'intravacuolar': [1922], '(FH-1)': [1929], 'explicitly': [1932], 'implicated': [1933, 2440], 'study,': [1950], 'although': [1951], 'not': [1952, 2376, 2438, 2451, 2772, 2941, 3701], 'directly': [1953, 2109], 'shown,': [1954], 'authors': [1956], 'FH-1': [1959, 2637, 2888], 'polymerises': [1960], 'transported': [1972, 2548], 'subalveolar': [1981], 'pole.': [1986, 2212, 3899], 'least': [1989], 'majority': [1994, 2174, 2650, 2849, 3640, 4135], 'appears': [1998, 2168, 2613], 'occur': [2000, 2045, 3645, 3702], 'cytosol': [2003, 2502, 2660, 2856, 2996, 3210, 3677], 'Golgi,': [2011], 'forming': [2012], 'periphery': [2021, 2867, 3450, 3946, 3958, 4059], 'basal': [2031, 3296, 3316, 3435, 3532, 3684, 3761, 3898, 3917, 4071, 4150, 4267], '2425.': [2033, 2675], 'addition,': [2035], 'measurement': [2036], 'peripheral': [2038, 3323, 4232], 'bidirectional': [2046, 2670, 3967], 'vice': [2055], 'versa': [2056], '25.': [2057, 2191], 'good': [2059, 2607, 2882, 3767], 'agreement': [2060, 2883, 3768], 'oriented': [2064], 'previous': [2067, 3978], 'reports': [2068], 'associated': [2074, 2726], 'connected': [2081, 3698], 'stabilise': [2084], '19202126.': [2087], 'gliding-associated': [2089], 'via': [2092], 'co-immunoprecipitation': [2093], 'recently': [2098], 'play': [2101], 'connecting': [2110, 3881], '2227,': [2116], 'connection': [2121], 'exists': [2122], 'network.': [2131], 'compared': [2134, 2825], 'WT': [2138, 2787, 3712, 3962], 'mutant': [2140, 2791, 2806, 3722], 'correlated': [2147], 'its': [2148, 2769], 'phenotypic': [2153, 2775], 'consequences': [2154], 'unstimulated': [2161], 'bidirectional,': [2171], 'events': [2176, 3735, 3970], 'occurring': [2177, 2667, 2868], 'direction,': [2181], 'which': [2182, 2477, 3608, 3825, 3985], 'measurements': [2186], 'performed': [2187, 3729], 'activation': [2193, 4096, 4193], 'calcium': [2195, 3410, 4122], 'signalling': [2196, 2513], 'results': [2197, 3192, 3979], 'shift': [2200], 'towards': [2201, 3032, 4057], 'flow,': [2204], 'accumulation': [2208, 2966, 3293, 3317, 3400, 3414, 3432, 3488, 3504, 3527, 4127, 4152], 'Comparison': [2213], 'helped': [2224], 'identify': [2226, 2484], 'translocate': [2250], 'potentially': [2252], 'deform': [2253], 'process.': [2258], 'strongly': [2261], 'analogy': [2274], 'observed': [2278, 2968, 3043, 3281, 3423, 3447], 'migration': [2280], 'constricted': [2286], 'environment': [2287], '28.': [2288], 'Results': [2289], 'Rational': [2290], 'selecting': [2292], 'order': [2296], 'Over': [2305], 'years,': [2307], 'conditional': [2308, 2805], 'mutagenesis': [2309], 'systems': [2310], 'employed': [2313, 3604], 'generate': [2315], 'characterise': [2317], 'whole': [2319], 'assortment': [2320], 'These': [2329], 'different,': [2335], 'unrelated': [2336], 'pathways,': [2337], 'microneme': [2340, 4195], 'secretion,': [2341], 'entry.': [2350], 'Since': [2351, 2721], 'interested': [2354, 2678], 'analysing': [2356], 'process,': [2362], 'chose': [2364, 2463], 'previously': [2369, 2481, 2515, 2838, 3776], 'characterised': [2370], 'significantly': [2373], 'affected,': [2374], 'blocked': [2377, 2400], 'linked': [2383], 'system.': [2388], 'excluded': [2390, 2430], 'all': [2391], 'completely': [2399, 2961, 3055, 3226], 'initiation': [2403], '23': [2409], 'MIC8': [2414], '29,': [2415], 'since': [2416], 'no': [2417, 3313, 3399, 3462], 'event': [2419], 'expected': [2422, 4258], 'analysed.': [2426], 'Similarly,': [2427], 'involved': [2432, 2452, 2717], 'FH-2,3': [2447], '11': [2448, 4092], 'myosins': [2450], 'MyoI': [2459], '30.': [2460], '79,': [2466], 'depolymerisation': [2469, 2813], 'factor': [2470, 2814], 'ADF': [2471, 2960, 4254], '31': [2472], 'myosin': [2474, 2793], '(MyoA),': [2476, 2795], 'used': [2480, 3548, 3933], 'successfully': [2483], 'mainly': [2498], 'organised': [2499], 'modulated': [2508], 'Calcium': [2510], 'cGMP': [2512], 'imaged': [2516], 'able': [2524], 'discriminate': [2526], 'centres,': [2530, 2620, 2988, 4028], 'apicoplast,': [2541], 'subsequently': [2547], 'end': [2552, 3436, 4245], '24.': [2556, 2843], 'Indeed,': [2557], '1125,': [2584], 'thought': [2596], 'agreement,': [2608], 'region': [2631, 3031, 3114, 3671, 3891, 4039], 'indicating': [2635], 'FH-2': [2639], 'acting': [2641], 'nucleators': [2643], 'development.': [2647], 'Intriguingly,': [2648], 'manner': [2671], '(retrograde': [2672], 'anterograde)': [2674], 'determine': [2680], 'if': [2681], 'time': [2690, 3073, 3147, 3371, 3861, 3867], 'patterns': [2695], 'differ': [2699], 'ones': [2703], 'how': [2705], 'they': [2706], 'impacted': [2708], 'upon': [2709, 3368, 3541], 'disruption': [2710, 2937], 'factors': [2715], 'critically': [2716], 'regulation.': [2720], 'transfections': [2723], 'overexpression': [2728], 'target': [2731], 'hence': [2733], 'uncontrolled': [2736], 'impact': [2737], 'equilibrium': [2741], 'lines': [2747, 2765], 'stably': [2748], 'expressing': [2749, 2784, 3016, 3238, 3302, 3348], 'Cb-EmeraldFP.': [2750, 3017], 'ensured': [2752, 2767], 'chromobody': [2758], 'comparable': [2760], 'does': [2771], 'lead': [2773, 4102], 'alterations': [2776], 'misleading': [2778], 'analysis.': [2779], 'established': [2781], 'transgenic': [2782], 'Cb-EmeraldFP': [2785, 3239, 3303, 3349], 'null': [2790, 4210], 'core': [2797], '16': [2802], 'critical': [2809], 'regulator,': [2811], 'ADF,': [2815], 'adfcKD': [2816], '31.': [2817], 'Using': [2818], 'live': [2819], '3D-structured': [2820], 'illumination': [2821], '(3D-SIM),': [2823], 'discernible': [2831], '(Fig': [2835, 2932, 2954, 2976, 3652, 3707, 3809, 4138, 4153, 4246, 4278], '1A)': [2836, 2911, 2924], 'seen': [2839, 3023, 3367], 'Time-lapse': [2844], 'some': [2861, 3322, 3442, 4231], 'detectable': [2864], 'anterograde': [2872], 'orientation,': [2873], '(see': [2878, 3004], '25).': [2880], 'FH-2,': [2890], 'detected.': [2896], 'starts': [2899], '(1st': [2904], 'centre,': [2906, 3116], 'yellow': [2907, 3065, 3119], 'arrow': [2908], 'Fig': [2910, 2923, 3813, 3870, 3951, 4001, 4141, 4156], 'second': [2914], '(red': [2921, 3175, 3426, 3437, 3672], 'arrow,': [2922], '1A,': [2933, 2955, 2977], 'Movie': [2934, 2956, 2978, 3005, 3078, 3152, 3376, 3654, 4143, 4158, 4248, 4280], 'EV1).': [2935, 2979, 3655], 'myoA': [2939, 3010, 3047, 3222, 3393, 3440, 3876, 3964], 'did': [2940, 3723], 'result': [2942], 'changes': [2945], 'resting': [2952], 'EV1),': [2957], 'depletion': [2958, 4252], 'abrogated': [2962], 'being': [2967], 'poles': [2975], 'Figure': [2980, 3587], 'nucleation': [2987, 3070, 3115, 3124], 'Stills': [3000], 'depicting': [3001, 3084], 'EV1)': [3006], 'RH,': [3009], 'KO': [3011, 3223, 3394, 3877, 3965], 'adf': [3013, 3050, 3232, 3345, 3460, 3905, 3982], 'KD': [3014, 3983], 'Continuous': [3018], 'parasite.': [3038, 3108, 3213, 3342, 3688, 4042], 'No': [3039, 3359], 'difference': [3040], 'RH': [3045, 3220, 3391, 3425, 3874], 'KO.': [3048], 'KD,': [3051, 3906], 'abrogated.': [3056], 'Red': [3057, 3109], 'arrowhead': [3058, 3066, 3110, 3120], 'marks': [3059, 3067, 3111, 3121], 'region,': [3062], 'centre.': [3071, 3125], 'lapse': [3074, 3148, 3372], 'presented': [3076, 3150, 3374, 3430, 3878, 4006], 'EV1.': [3079, 3153], 'Skeletonisation': [3080, 3378], 'processing': [3081, 3606], '(A)': [3083, 3157], 'areas': [3085], 'dynamics/flow': [3088], 'prevalent.': [3090], 'Individual': [3091], 'signals': [3092, 3611, 3880, 3909], 'form': [3095], 'continuous,': [3097], 'connects': [3101, 3754, 4067], 'images': [3127, 3466], 'projection': [3130, 3469], 'frames': [3132, 3471], 'each': [3134, 3473, 3705, 3794], 'timepoint': [3135, 3474], 'provide': [3137, 3476], 'better': [3139, 3478], 'overview': [3140, 3479], 'Kymograph': [3154], '(B).': [3159], 'kymograph': [3161, 3179, 3726, 3816], 'tracing': [3165], 'line': [3167], 'middle': [3170], 'body': [3174, 3996], 'line).': [3176], 'colour-coded': [3178, 3791], 'represents': [3180], 'forward': [3181, 3798], 'movement': [3182, 3185, 3799, 3802], '(red),': [3183, 3800], 'backward': [3184, 3801], '(green)': [3186, 3803], 'static': [3188, 3805, 3908], '(blue).': [3190], 'demonstrate': [3193], 'abolished': [3227], 'case': [3230, 3458, 3902], 'KD.': [3233], 'Top': [3234], 'rows:': [3236], 'Parasites': [3237], 'along': [3240, 3956], 'myoA-SNAP': [3242], 'before': [3243, 3304, 3350, 3489], 'after': [3245, 3306, 3352, 3491, 3505], 'Ca2+': [3246, 3355, 3494, 3507], 'ionophore': [3247, 3356, 3411, 3495, 3508, 4123], '(A23187)': [3248], 'BIPPO': [3250, 3290, 3429, 4146, 4160, 4276], 'treatment.': [3251, 3369], 'treated': [3256], 'μM': [3259], 'cytochalasin': [3261], 'D': [3262], 'DMSO': [3264], '(as': [3265], 'control)': [3266], '30': [3268], 'min.': [3269], 'After': [3270, 3407], 'addition': [3272, 3288, 3386, 4277], 'A23187,': [3274, 3412], 'preferential': [3275, 3413, 3431], 'relocalisation': [3276, 3443, 3463], 'caused': [3291], 'end.': [3297], '4th': [3298], 'row:': [3299, 3344], 'myoAKO': [3300, 3714], 'treatment': [3307, 3353, 3408, 3492, 4117], 'A23187': [3309, 3332, 3388, 4124, 4217, 4274], 'BIPPO.': [3311, 3358, 3497, 3510], 'observed,': [3321], 'presence': [3330, 3743], 'BIPPO,': [3334, 3390, 4219], 'half': [3339, 3998, 4237], 'Bottom': [3343], 'cKD': [3346], 'apparent': [3360], 'change': [3361], 'EV2.': [3377], 'movies': [3380], 'shown': [3381, 3808, 3868], '(D).': [3383], 'Before': [3384], 'behave': [3396], 'tip.': [3406, 3533], 'arrowhead),': [3427, 3673], 'arrowhead).': [3438, 3455], 'KO,': [3441], '(yellow': [3454, 3667], 'cKD,': [3461], 'occurs.': [3464], 'Quantification': [3485], 'counted': [3501, 3540], 'adding': [3506], 'Numbers': [3511, 3567], 'counting': [3515], 'total': [3516], 'number': [3517, 3522], 'then': [3521, 3818, 3840], 'minimum': [3535], '200': [3537], 'biological': [3543], 'replicates.': [3544], 'Two-way': [3545], 'ANOVA': [3546], 'statistical': [3550], "Tukey's": [3553], 'comparison': [3555], 'test.': [3556], '****P': [3557], '<': [3558], '0.0001.': [3559], 'Error': [3560], 'bars': [3561, 3572], 'standard': [3563], 'deviation.': [3564], 'Data': [3565, 3585], 'information:': [3566], 'indicate': [3568], 'minutes:seconds,': [3569], 'scale': [3571], '5': [3574], 'μm.': [3575], 'data': [3577, 4005, 4284], 'available': [3579], 'online': [3580], 'figure.': [3583], '1': [3588], '[embr201948896-sup-0011-SDataFig1.zip]': [3589], 'Download': [3590, 3592], 'figure': [3591], 'PowerPoint': [3593], 'To': [3594], 'map': [3595], 'structures': [3598], 'visualised': [3599], 'chromobody,': [3602], 'skeletonisation': [3605], '32,': [3607], 'converts': [3609], 'individual': [3613, 3732], 'pixels,': [3614], 'traced': [3618], 'obtain': [3620], 'information': [3621], 'about': [3622], 'skeletonised': [3631], 'movie': [3632, 3651], 'projected': [3635], '(detectable)': [3642], 'timeline': [3648], '1B,': [3653], 'confirmed': [3658], 'arrowhead)': [3668], 'converge': [3674], 'reach': [3682], 'peripherical': [3691], 'cytoplasmic': [3693], 'do': [3700], '1B).': [3708], 'Note': [3709], 'displayed': [3716], 'signals,': [3718], 'whereas': [3719], 'ADF—conditional': [3721], 'not.': [3724], 'Next,': [3725, 3931], 'KymographClear': [3737, 3782], 'KymographDirect': [3739, 3823], '33': [3740], 'confirming': [3741, 3922, 3977], 'pole,': [3757], 'Formins': [3775], 'FIJI': [3785], 'plugin': [3786], 'generates': [3788], 'kymograph,': [3792], 'colour': [3795], 'labels': [3796], 'either': [3797], '(blue)': [3806], '1C': [3810], 'Appendix': [3812, 4000, 4140, 4155], 'S1).': [3814], 'read': [3820], 'software,': [3824], 'uses': [3826], 'automatic': [3827], 'trace': [3830], 'trajectories': [3831, 3844], 'moving': [3833], 'particles': [3834], 'image.': [3837], 'Values': [3838], 'assigned': [3841], 'intensity': [3848, 3853, 3865, 3938], 'speed': [3850], '33.': [3851], 'assessed': [3856], 'specified': [3858], 'tracks': [3859], 'over': [3860, 3866], 'average': [3864], '1C.': [3871], 'Both': [3872], '(close': [3885], '0),': [3889], '(between': [3892], 'μm)': [3896], 'only': [3907], 'could': [3910], 'detected': [3912], 'mutants.': [3930], 'investigate': [3937], 'profiles': [3939], 'signal': [3942, 4202], 'travelling': [3943], '(Appendix': [3950], 'S1B–D).': [3952], 'revealed': [3972], 'kymographs,': [3975], 'mutants,': [3984], 'shows': [3986], 'across': [3992], 'entire': [3994], '(first': [3997], '(−),': [3999], 'S1A–C).': [4002], 'Together,': [4003, 4282], 'work': [4009], 'similarly': [4012], 'displaying': [4024], 'another': [4035], 'Of': [4043], 'note,': [4044], 'underlines': [4047], 'there': [4049], 'coming': [4053], 'cytoplasm': [4056, 4228], 'shaping': [4061], 'therefore': [4076], 'any': [4079], 'positioned': [4082], "zoite's": [4085], 'IMC.': [4088], 'Tosetti': [4089], 'et': [4090], 'al': [4091], 'Ca2+-signalling': [4099], 'cascade': [4100], 'would': [4101], 'increased': [4104], 'transport': [4106], 'eventually': [4109], 'accumulating': [4110, 4262], 'posteriorly.': [4111], 'induced': [4125], 'anterior': [4126], 'wild-type': [4131], 'cases': [4137], '1D–F;': [4139, 4154, 4247, 4279], 'S1A;': [4142, 4157], 'EV2),': [4144], 'triggered': [4147], 'EV2).': [4159, 4249, 4281], 'drug': [4163], 'capable': [4164], 'inhibiting': [4166], '3′,5′-cyclic': [4167], 'nucleotide': [4168], 'phosphodiesterases': [4169], '(PDEs)': [4170], 'responsible': [4171, 4190], 'blocking': [4173], 'breakdown': [4175], 'cyclic': [4177], 'nucleotides': [4178], 'cAMP': [4181], 'cGMP.': [4183], 'believed': [4187], 'egress': [4198], 'modulating': [4200], 'pathway': [4203], 'PKG-dependent': [4205], 'processes': [4206], '34.': [4207], 'Once': [4208], 'MyoA': [4209], 'submitted': [4213], 'treatments': [4215], 'remained': [4222], 'rather': [4223], 'evenly': [4224], 'distributed': [4225], 'albeit': [4229], 'enrichment': [4233], 'closer': [4241], 'contrast,': [4251], 'led': [4255], 'phenotype': [4259], 'calci': [4287]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2977519297', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 3}], 'updated_date': '2024-12-29T16:08:57.782007', 'created_date': '2019-10-10'}
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