Title: Effects of shenmai injection on cardiac function and hemorheology in patients with acute exacerbation of senile chronic pulmonary heart disease
Abstract: Objective: To observe effects of shenmai injection (SMI) on cardiac function and hemorheology in patients with acute exacerbation of senile chronic pulmonary heart disease (CPHD). Methods: Seventy-eight cases of CPHD complicated cardiac dysfunction were divided randomly into observation group (40 cases) and control group (38 cases). The observation group was treated with combined therapy of SMI and conventional medicines, the control group was treated with conventional medicine only? there were 2 weeks for therapy course in both 2 groups. Cardiac function was assessed by pulsed Doppler echocardiography and the parameters of hemorheology were measured before and after therapy. Results: In observation group, cardiac output., cardiac index and ejection fraction were significantly increased (P0. 01 all) and observation on hemorheology showed that whole blood viscosity under low or high shear state, plasma viscosity, erythrocyte aggregation index, erythrocyte electrophoresis time and hematocrit, platelet agglutinate rate and fibrinogen after SMI treatment were meekly reduced (P0. 01 or P0. 05), the improvement of cardiac function and hemorheology in observation group were better than those of the control group (P0. 05). The clinical total effective rates and obvious effective rates in observation group were 90. 0% and 50. 0% respectively; they were higher than those of control group (71. 1% and 26. 3%). There was obvious difference between 2 groups (P 0.05). No severe adverse effect was found in treating with SMI. Conclusion: SMI can obviously improve cardiac function and blood hemorheology in patients with acute exacerbation of CPHD. It is one of effective and safe drug for treatment of CPHD.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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Cited By Count: 2
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