Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2976965029', 'doi': 'https://doi.org/10.1093/protein/gzz025', 'title': 'Improving folding properties of computationally designed proteins', 'display_name': 'Improving folding properties of computationally designed proteins', 'publication_year': 2019, 'publication_date': '2019-03-01', 'ids': {'openalex': 'https://openalex.org/W2976965029', 'doi': 'https://doi.org/10.1093/protein/gzz025', 'mag': '2976965029', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31553452'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/protein/gzz025', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44492648', 'display_name': 'Protein Engineering Design and Selection', 'issn_l': '1741-0126', 'issn': ['1741-0126', '1741-0134'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089331183', 'display_name': 'Benjamin Bjerre', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Benjamin Bjerre', 'raw_affiliation_strings': ['The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark'], 'affiliations': [{'raw_affiliation_string': 'The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035136994', 'display_name': 'Jakob Nybo Nissen', 'orcid': 'https://orcid.org/0000-0003-2860-7982'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Jakob Nissen', 'raw_affiliation_strings': ['The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark'], 'affiliations': [{'raw_affiliation_string': 'The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088586630', 'display_name': 'Mikkel Madsen', 'orcid': 'https://orcid.org/0000-0002-3748-9132'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Mikkel Madsen', 'raw_affiliation_strings': ['The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark'], 'affiliations': [{'raw_affiliation_string': 'The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074890266', 'display_name': 'Jūratė Fahrig‐Kamarauskaitė', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Jūratė Fahrig-Kamarauskaitė', 'raw_affiliation_strings': ['The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark'], 'affiliations': [{'raw_affiliation_string': 'The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062609591', 'display_name': 'Rasmus K. Norrild', 'orcid': 'https://orcid.org/0000-0002-9120-2745'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Rasmus K Norrild', 'raw_affiliation_strings': ['The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark'], 'affiliations': [{'raw_affiliation_string': 'The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038332034', 'display_name': 'Peter Christoffer Holm', 'orcid': 'https://orcid.org/0000-0003-3363-5611'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Peter C Holm', 'raw_affiliation_strings': ['The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark'], 'affiliations': [{'raw_affiliation_string': 'The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049059053', 'display_name': 'Mathilde K Nordentoft', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Mathilde K Nordentoft', 'raw_affiliation_strings': ['The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark'], 'affiliations': [{'raw_affiliation_string': 'The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027238071', 'display_name': 'Charlotte O’Shea', 'orcid': 'https://orcid.org/0000-0002-5548-8002'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Charlotte O’Shea', 'raw_affiliation_strings': ['The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark'], 'affiliations': [{'raw_affiliation_string': 'The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020399284', 'display_name': 'Martin Willemoës', 'orcid': 'https://orcid.org/0000-0003-1689-2712'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Martin Willemoës', 'raw_affiliation_strings': ['The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark'], 'affiliations': [{'raw_affiliation_string': 'The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078516822', 'display_name': 'Kristoffer E. Johansson', 'orcid': 'https://orcid.org/0000-0001-6054-0461'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Kristoffer E Johansson', 'raw_affiliation_strings': ['The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark'], 'affiliations': [{'raw_affiliation_string': 'The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056900972', 'display_name': 'Jakob R. Winther', 'orcid': 'https://orcid.org/0000-0001-6995-9154'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': True, 'raw_author_name': 'Jakob R Winther', 'raw_affiliation_strings': ['The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark'], 'affiliations': [{'raw_affiliation_string': 'The Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University for Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5056900972'], 'corresponding_institution_ids': ['https://openalex.org/I124055696'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.411, 'has_fulltext': False, 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.536677, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '32', 'issue': '3', 'first_page': '145', 'last_page': '151'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.9891, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9862, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/folding', 'display_name': 'Folding (DSP implementation)', 'score': 0.84263027}, {'id': 'https://openalex.org/keywords/protein-design', 'display_name': 'Protein design', 'score': 0.4232862}, {'id': 'https://openalex.org/keywords/protein-engineering', 'display_name': 'Protein Engineering', 'score': 0.4203133}], 'concepts': [{'id': 'https://openalex.org/C2776545253', 'wikidata': 'https://www.wikidata.org/wiki/Q5464292', 'display_name': 'Folding (DSP implementation)', 'level': 2, 'score': 0.84263027}, {'id': 'https://openalex.org/C204328495', 'wikidata': 'https://www.wikidata.org/wiki/Q847556', 'display_name': 'Protein folding', 'level': 2, 'score': 0.7434537}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.5657287}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.56531}, {'id': 'https://openalex.org/C81917197', 'wikidata': 'https://www.wikidata.org/wiki/Q628760', 'display_name': 'Selection (genetic algorithm)', 'level': 2, 'score': 0.5372425}, {'id': 'https://openalex.org/C152769699', 'wikidata': 'https://www.wikidata.org/wiki/Q410814', 'display_name': 'Protein design', 'level': 3, 'score': 0.4232862}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.42179394}, {'id': 'https://openalex.org/C147816474', 'wikidata': 'https://www.wikidata.org/wiki/Q169525', 'display_name': 'Protein engineering', 'level': 3, 'score': 0.4203133}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39214543}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.33604118}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.31887195}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3133496}, {'id': 'https://openalex.org/C47701112', 'wikidata': 'https://www.wikidata.org/wiki/Q735188', 'display_name': 'Protein structure', 'level': 2, 'score': 0.2903106}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.18596423}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.092924565}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.08154419}, {'id': 'https://openalex.org/C154945302', 'wikidata': 'https://www.wikidata.org/wiki/Q11660', 'display_name': 'Artificial intelligence', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C119599485', 'wikidata': 'https://www.wikidata.org/wiki/Q43035', 'display_name': 'Electrical engineering', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015202', 'descriptor_name': 'Protein Engineering', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015202', 'descriptor_name': 'Protein Engineering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/protein/gzz025', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44492648', 'display_name': 'Protein Engineering Design and Selection', 'issn_l': '1741-0126', 'issn': ['1741-0126', '1741-0134'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31553452', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 19, 'referenced_works': ['https://openalex.org/W116193106', 'https://openalex.org/W131278278', 'https://openalex.org/W1519297291', 'https://openalex.org/W1984640298', 'https://openalex.org/W2013532519', 'https://openalex.org/W2014770547', 'https://openalex.org/W2038139711', 'https://openalex.org/W2038263678', 'https://openalex.org/W2045777307', 'https://openalex.org/W2092649349', 'https://openalex.org/W2101868444', 'https://openalex.org/W2137612801', 'https://openalex.org/W2154269189', 'https://openalex.org/W2173280871', 'https://openalex.org/W2314805854', 'https://openalex.org/W2412714128', 'https://openalex.org/W2484019349', 'https://openalex.org/W2522711130', 'https://openalex.org/W2777217859'], 'related_works': ['https://openalex.org/W2991203454', 'https://openalex.org/W2991041010', 'https://openalex.org/W2976965029', 'https://openalex.org/W2512252615', 'https://openalex.org/W2382178265', 'https://openalex.org/W2260493136', 'https://openalex.org/W2116266427', 'https://openalex.org/W2113188411', 'https://openalex.org/W2003675367', 'https://openalex.org/W1999385709'], 'abstract_inverted_index': {'While': [0], 'the': [1, 50, 111, 131], 'field': [2], 'of': [3, 35, 65, 75], 'computational': [4], 'protein': [5, 113, 123], 'design': [6, 105], 'has': [7], 'witnessed': [8], 'amazing': [9], 'progression': [10], 'in': [11, 85], 'recent': [12], 'years,': [13], 'folding': [14, 33, 43, 70, 92, 109, 117, 134], 'properties': [15, 34, 71], 'still': [16], 'constitute': [17], 'a': [18, 41, 103, 107, 125, 141], 'significant': [19], 'barrier': [20], 'towards': [21], 'designing': [22], 'new': [23, 143], 'and': [24, 31, 45, 72, 93, 135, 137, 147], 'larger': [25], 'proteins.': [26, 95], 'In': [27, 122], 'order': [28], 'to': [29, 145], 'assess': [30], 'improve': [32, 148], 'designed': [36], 'proteins,': [37], 'we': [38, 79], 'have': [39], 'developed': [40], 'genetics-based': [42], 'assay': [44], 'selection': [46, 74], 'system': [47, 60], 'based': [48], 'on': [49], 'essential': [51], 'enzyme,': [52], 'orotate': [53], 'phosphoribosyl': [54], 'transferase': [55], 'from': [56], 'Escherichia': [57], 'coli.': [58], 'This': [59], 'allows': [61], 'for': [62], 'both': [63], 'screening': [64], 'candidate': [66, 149], 'designs': [67, 88], 'with': [68, 118], 'good': [69], 'genetic': [73], 'improved': [76, 120], 'designs.': [77, 150], 'Thus,': [78], 'identified': [80], 'single': [81, 126], 'amino': [82, 127], 'acid': [83, 128], 'substitutions': [84, 99], 'two': [86], 'failed': [87], 'that': [89], 'rescued': [90], 'poorly': [91], 'unstable': [94], 'Furthermore,': [96], 'when': [97], 'these': [98], 'were': [100], 'transferred': [101], 'into': [102], 'well-structured': [104], 'featuring': [106], 'complex': [108], 'profile,': [110], 'resulting': [112], 'exhibited': [114], 'native-like': [115], 'cooperative': [116], 'significantly': [119], 'stability.': [121], 'design,': [124], 'can': [129], 'make': [130], 'difference': [132], 'between': [133], 'misfolding,': [136], 'this': [138], 'approach': [139], 'provides': [140], 'useful': [142], 'platform': [144], 'identify': [146]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2976965029', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}], 'updated_date': '2024-12-24T12:58:28.234322', 'created_date': '2019-10-03'}