Title: Deficient inhibition in alcohol-dependence: What is the impact of craving?
Abstract: Event Abstract Back to Event Deficient inhibition in alcohol-dependence: What is the impact of craving? Caroline Quoilin1*, Astrid Carton De Tournai1, Celia De Clerck1, Philippe De Timary1 and Julie Duque1 1 Institute of NeuroScience, Université Catholique de Louvain, Belgium Converging lines of evidence suggest that both alcohol craving and impaired inhibitory control contribute to the maintenance and relapse of alcohol dependence. However, whether craving worsens inhibitory performance is still unclear. Here, we aimed at studying whether the induction of craving, by means of 360° immersive videos (bar compared to library), alters the strength of motor inhibition in alcohol-dependent (AD) patients. Motor inhibition was evaluated using a standard procedure consisting in measuring motor-evoked potentials elicited by single-pulse transcranial magnetic stimulation over primary motor cortex during a choice reaction time task. Our data indicate a strong shortage of motor inhibition in AD patients relative to control subjects, consistent with an inhibitory deficit. Importantly, this deficit was comparable following videos placing patients in a bar or in a library. Accordingly, we found that the former video did not induce craving in the patients. This result is surprising given that we previously demonstrated that the same video was effective in eliciting alcohol craving in young social drinkers. Interestingly, the level of presence experienced during the immersion was lower in patients compared to controls and social drinkers, which may indicate that patients deployed some strategies to avoid being impacted by the immersive videos. Keywords: Alcohol dependance, motor inhibition, virtual reality, transcrancial magnetic stimulation (TMS), Alcohol craving Conference: 13th National Congress of the Belgian Society for Neuroscience , Brussels, Belgium, 24 May - 24 May, 2019. Presentation Type: Poster presentation Topic: Behavioral/Systems Neuroscience Citation: Quoilin C, Carton De Tournai A, De Clerck C, De Timary P and Duque J (2019). Deficient inhibition in alcohol-dependence: What is the impact of craving?. Front. Neurosci. Conference Abstract: 13th National Congress of the Belgian Society for Neuroscience . doi: 10.3389/conf.fnins.2019.96.00079 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Apr 2019; Published Online: 27 Sep 2019. * Correspondence: PhD. Caroline Quoilin, Institute of NeuroScience, Université Catholique de Louvain, Louvain-la-Neuve, Walloon Brabant, 1200 Brussels, Belgium, [email protected] Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Caroline Quoilin Astrid Carton De Tournai Celia De Clerck Philippe De Timary Julie Duque Google Caroline Quoilin Astrid Carton De Tournai Celia De Clerck Philippe De Timary Julie Duque Google Scholar Caroline Quoilin Astrid Carton De Tournai Celia De Clerck Philippe De Timary Julie Duque PubMed Caroline Quoilin Astrid Carton De Tournai Celia De Clerck Philippe De Timary Julie Duque Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.