Paul Greengard, Ph.D. (1925‐2019)

Name: Work Video:
Duration: 3 min 30 s
Sam Gandy; Toshiharu Suzuki
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'enjoyed': [82, 563, 581, 4037], 'richness': [84], 'that': [85, 362, 399, 410, 460, 518, 539, 566, 776, 779, 887, 980, 1014, 1121, 1264, 1451, 1587, 1602, 1648, 1683, 1772, 1856, 1896, 1935, 1978, 1988, 2067, 2110, 2167, 2209, 2245, 2249, 2274, 2312, 2350, 2422, 2448, 2532, 2560, 2566, 2585, 2598, 2617, 2663, 2676, 2684, 3026, 3324, 3529, 3551, 3559, 3604, 3668, 3703, 3728, 3841, 3974, 4042, 4071, 4079, 4182, 4326, 4336, 4466, 4477, 4484, 4498, 4608, 4657, 4670], 'life': [88], 'devoted': [89, 207], 'science': [92, 1715], 'wife,': [96], 'sculptor': [97], 'Ursula': [98, 108], 'von': [99], 'Rydingsvard,': [100], 'survives': [102], 'him.': [103], "Paul's": [104, 328, 400, 801, 829, 939, 1556, 1660, 1695, 1714, 1734, 2201, 2603, 4101, 4205, 4257, 4333, 4376], 'favorite': [105], 'name': [106, 802, 2335], 'for': [107, 161, 577, 694, 741, 752, 864, 867, 879, 1081, 1233, 1331, 1590, 1954, 2049, 2236, 2328, 2463, 2507, 2518, 2520, 2540, 2644, 2838, 2995, 3087, 3574, 3585, 3738, 3818, 3882, 4059, 4292, 4299, 4415, 4443, 4450, 4570, 4580], '“Dolly”,': [110], 'as': [114, 121, 145, 191, 524, 659, 719, 724, 1054, 1124, 1467, 1538, 1638, 2119, 2267, 2526, 2737, 2762, 2767, 2829, 2882, 2983, 3147, 3677, 3733, 3739, 3922, 4146, 4387, 4421, 4486, 4629], 'smitten': [115], 'with': [116, 198, 244, 291, 345, 373, 380, 394, 428, 436, 532, 629, 636, 698, 845, 1196, 1475, 1536, 1672, 1819, 1860, 1879, 2012, 2059, 2112, 2176, 2283, 2338, 2388, 2397, 2455, 2534, 2580, 2875, 2968, 2973, 3332, 3347, 3463, 3515, 3664, 3704, 3879, 3906, 4339, 4620], 'enchanted': [118], 'humanly': [123], 'possible.': [124], 'Over': [125], 'past': [127, 165, 1112, 3776, 4192, 4236], 'decades,': [128], 'originality': [130], 'soulfulness': [132], "Ursula's": [134], 'work': [135, 421, 1204, 1878, 2051, 4211], 'had': [136, 255, 302, 625, 1354, 1434, 1435, 1716, 1723, 1851, 1869, 1984, 2075, 2246, 2276, 2293, 2324, 2351, 2618, 2665, 2678, 2890, 2943, 3011, 3028, 3678, 4002, 4534], 'grown': [137], 'rapidly,': [138], 'garnering': [139], 'a': [141, 146, 212, 230, 277, 341, 346, 386, 437, 525, 533, 549, 665, 757, 770, 785, 984, 1102, 1152, 1214, 1269, 1281, 1286, 1289, 1429, 1436, 1481, 1561, 1577, 1624, 1673, 1731, 1737, 1752, 1760, 1784, 1795, 1805, 1826, 1873, 1908, 1922, 1979, 2010, 2027, 2043, 2120, 2155, 2164, 2268, 2289, 2329, 2398, 2485, 2511, 2611, 2647, 2685, 2733, 2744, 2752, 2777, 2802, 2963, 3129, 3162, 3302, 3448, 3461, 3491, 3512, 3572, 3594, 3855, 3874, 3929, 3932, 3991, 3996, 4020, 4085, 4088, 4137, 4320, 4358, 4400, 4469, 4487, 4566], 'well-deserved': [142], 'international': [143], 'reputation': [144], 'singular': [147, 4180], 'talent.': [148], 'biggest': [152], 'fan': [153], 'cheerleader.': [155], 'Back': [156, 2320, 4156], 'laboratory': [159, 196, 248, 916, 1200, 1398, 1440, 1558, 1696, 1883, 2074, 2298, 2487, 2604, 2789, 3182, 3187], 'most': [162, 337, 657, 1175, 2433, 3310, 4196, 4209], '30': [166, 181], 'any': [169, 2460], 'one': [170, 203, 654, 671, 1649, 2102, 2527, 2899, 2984, 3826], 'time,': [171, 1637, 2785, 2798, 3656], 'oversaw': [173], 'graduate': [174, 1806, 2330], 'students': [175, 679, 713], 'fellows': [177], 'totaled': [179], 'between': [180, 3179, 3395], '50': [183, 1066], 'number.': [185], 'His': [186], 'brilliance': [187], 'often': [189, 275, 286, 383, 692, 1686, 3951], 'breathtaking': [190], 'personally': [193], 'ran': [194], 'weekly': [195], 'meetings,': [197], 'each': [199, 234, 484, 644, 3962], "week's": [200], 'session': [201, 1973, 1990], 'two': [205, 1328, 2457, 3209, 4050], 'hours': [206, 706], 'progress': [210], 'single': [213, 2612], 'student.': [214], 'The': [215, 317, 419, 623, 901, 993, 1032, 1086, 1484, 1508, 1893, 2001, 2055, 2258, 2372, 2381, 2642, 2758, 3286, 3418, 3947, 4097, 4349, 4413, 4490, 4531], 'student': [216, 469, 624, 767, 1807, 2331, 3107, 3454], 'expected': [218], 'project': [220, 1753, 3040], 'well-labeled': [221], 'images': [222, 472], 'primary': [227], 'data,': [228], 'perform': [229], 'careful': [231, 639], 'recitation': [232, 949], 'step': [237], 'protocol,': [240], 'then': [242, 504, 599, 1644, 1804, 1825, 2009, 2023, 3511, 3593, 4012], 'share': [243], 'whatever': [249], 'tentative': [250, 451], 'conclusions': [251, 3956], 'she': [254], 'drawn.': [256], 'Typically,': [257], "student's": [259], 'version': [260], 'this': [262, 510, 852, 1998, 2133, 2479, 2592, 2784, 2896, 2940, 2960, 3655, 3747, 4038, 4145, 4179, 4556], 'narrative': [263, 1068], 'followed': [265, 648], 'comments': [267], 'from': [268, 446, 904, 996, 1007, 1034, 1058, 1207, 1368, 1725, 1913, 2253, 2285, 2295, 2380, 2575, 3216, 3266, 3358, 3998, 4418, 4510, 4552], 'spoke': [271], 'definitive': [273], 'interpretation,': [274], 'semimonotone': [278], 'aimed': [279, 1757], 'elucidation': [281], 'not': [283, 403, 717, 734, 807, 860, 1554, 2713, 2915, 3012, 3095, 3416, 4314], 'humiliation.': [284], 'broke': [287], 'up': [288, 1367, 1718, 3978], 'these': [289, 519, 575, 1651, 2210, 3423], 'moments': [290, 704, 1968], 'levity,': [293], 'after': [295, 1532, 2726, 3136, 4063, 4332], 'room': [297, 1563, 2056, 2105], 'chuckled': [298], 'tension': [301], 'been': [303, 1985, 2325, 3013, 3029, 3679, 3772, 4003], 'dispersed,': [304], 'speaker': [306, 2002], 'would': [307, 321, 343, 370, 376, 382, 397, 475, 493, 540, 568, 590, 601, 768, 783, 890, 1604, 1653, 1877, 1887, 1936, 1991, 2150, 2423, 2985, 3950, 3975, 4197], 'go': [308, 1380], 'next': [312], 'experiment,': [313], 'autoradiogram,': [314], 'micrograph.': [316], 'successful': [318, 1045, 2516], 'trainee': [320], 'typically': [322, 591], 'learn': [323], 'coauthor': [325], 'papers': [326, 520], 'under': [327, 3407], 'personal': [329], 'tutelage': [330], 'extended': [332, 796, 4030], 'one-on-one': [333, 426, 695], 'sessions.': [334], 'In': [335, 955, 2221, 2980, 3200, 3825, 3854, 3917, 4335, 4370], 'its': [336, 1224, 2089, 3033, 3264, 3273, 3296, 3586, 3697], 'straightforward': [338], 'incarnation,': [339], 'such': [340, 2646, 3146, 3550, 3702, 3732, 4420], 'paper': [342, 366, 778], 'few': [347, 758, 4138], 'rounds': [348], 'drafting': [350], 'editing': [352], 'first': [355, 498, 597, 1113, 1194, 1279, 1597, 1631, 2343, 2493, 2626, 3419, 3446, 3834, 4389], 'author': [356, 2015], 'middle': [359], 'authors.': [360, 3985], 'When': [361, 1692], 'group': [363, 1578, 3176], 'pronounced': [364, 1371], 'ready,': [367], 'draft': [369], 'be': [371, 571, 784, 983, 1907, 2005, 2851, 3301, 3718, 3736, 3952, 4073, 4480], 'shared': [372, 822, 841, 1085, 2173], 'review': [377], 'annotate': [379], 'what': [381, 2521, 2763, 3223], 'look': [384], 'like': [385, 3568], 'manageable': [387], 'volume': [388], 'revisions.': [390], 'However,': [391, 3588], 'anyone': [392, 1390], 'familiar': [393], 'process': [396, 2734], 'realize': [398, 4653], 'markup': [401], 'did': [402], 'indicate': [404], 'near': [405], 'completion': [406], 'rather': [408], 'evidence': [409, 1855, 2235, 4465, 4476], 'maestro': [412], 'ready': [414], 'earnest.': [418], 'serious': [420], 'performed': [423], 'sessions': [427, 433, 697, 701, 727, 3949], '(Fig.': [430, 1029], '1).': [431], 'These': [432, 700, 726, 3885], 'usually': [434, 4069], 'began': [435, 1228], 'multistack': [438], 'spread': [439, 3178], 'pages': [441], 'across': [442, 3238], 'writing': [444, 635, 696, 782, 3948], 'table—usually,': [445], 'left': [447, 2724, 4618], 'right,': [449], 'figures,': [452], 'their': [453, 774, 937, 2366, 2415, 4029, 4355], 'legends,': [454], 'corresponding': [457], 'results': [458], 'sections—so': [459], 'it': [461, 515, 896, 2280, 3280, 4049, 4072], 'obvious': [463], 'exactly': [470, 2645], 'which': [471, 479, 557, 1082, 1139, 2097, 2825, 2873, 3614, 4001], 'reader': [474], 'see': [476], 'sequence.': [480], 'carefully': [482], 'cross-compared': [483], 'three': [487], 'components.': [488], 'He': [489, 561, 663, 1383, 3936, 4110, 4382], '(or': [490, 1149], 'student)': [492], 'read': [494], 'word': [496, 645], 'aloud,': [497], 'those': [499, 505, 868, 880, 1247, 2240, 2475], 'legend': [502], 'text.': [508], 'If': [509], 'sounds': [511, 854], 'excruciating,': [512], "that's": [513], 'because': [514, 634, 837, 2135, 2710, 2739, 3723], 'clear': [517, 2651], 'being': [522, 1208, 2600, 2689, 3061, 3085, 4084], 'written': [523], 'part': [526, 3014, 4147], 'permanent': [529], 'scientific': [530], 'record': [531, 1388], 'level': [534], 'rigor': [536], 'accuracy': [538], 'stand': [541], 'test': [543], 'time.': [545, 4129], 'connoisseur': [550], 'anecdotes': [552], 'malapropisms,': [554], 'many': [555], 'sidesplittingly': [559], 'hilarious.': [560], 'so': [562, 735, 1108, 1335, 1685, 1987, 4040, 4078], 'some': [564, 1656, 1852, 3724, 4133], 'favorites': [565], 'ask': [569, 592, 2429, 4638], 'told': [572, 4065], 'retold': [574], 'jokes': [576], 'decades.': [578], 'Moreover,': [579, 4062], 'both': [582, 609, 1336, 1702, 2541, 3928, 3984], 'hearing': [584, 611], 'telling,': [587], 'hear': [594], 'story': [596, 604, 4039], 'retell': [602], 'himself,': [605], 'laughingly': [606], 'heartily': [607, 4058], 'telling.': [614], 'From': [615, 1094], 'Nestler': [616], 'EJ,': [617], 'Huganir,': [618], 'Cell': [619, 2662, 2805], '177,': [620], '1365-1366,': [621], '2019.': [622], 'better': [626, 666], 'have': [627, 934, 2151, 3726, 3771, 4459, 4533, 4545], 'arrived': [628, 899, 1743, 2247], 'patience': [631], 'Job': [633], 'involved': [638], 'deliberate': [641], 'selection': [642], 'phrase': [647], 'testing': [650], 'sentence': [651, 3963], 'structures': [652], 'until': [653, 4190], 'sounded': [655], 'euphonious': [658], 'judged': [660], 'Paul.': [662, 699], 'grammarian': [667], 'editor': [669], 'than': [670, 1712], 'might': [672, 3735, 4609], 'imagine,': [673], 'and—to': [674], 'end—for': [676], 'fortunate': [678], 'whose': [680, 2334, 3111], 'data': [681], 'moving': [683], 'into': [684, 1213, 1361, 2451, 2693, 3275], 'manuscript': [686], 'form,': [687], 'evenings': [688], 'weekends': [690], 'reserved': [693], 'when': [707, 762, 800, 882, 1041, 1741, 1974, 2062, 2652, 3025, 3378, 3383, 3410, 3638, 3957, 4023, 4115, 4195, 4213, 4220], 'got': [709], 'know': [711], 'vice': [715], 'versa,': [716], 'simply': [718], 'mentor': [720], 'mentee,': [722], 'friends.': [725], 'may': [728], 'sound': [729], 'dry,': [730], 'they': [732, 780, 2136, 2203, 2664, 2677, 2711, 4024], 'all.': [737], 'There': [738, 792, 4462, 4564], 'breaks': [740], 'dog': [742], 'walking,': [743], 'snacking,': [744], 'chatting,': [746], 'there': [748, 981, 1778, 1929, 2609, 4473], 'always': [750, 4111], 'gossip': [753], 'including': [754], 'least': [756], 'minutes': [759, 1994], 'schadenfreude': [761], 'either': [763], 'contemplate': [769], "competitor's": [771], 'misfortune': [772], 'hope': [775], 'major': [786, 788, 944, 2028, 4263, 4359, 4567], 'scoop,': [787], 'breakthrough,': [789], 'both.': [791], 'also': [794, 1480, 2920, 3102], 'an': [795, 1209, 1511, 1931, 1970, 2138, 2358, 2452, 2555, 2992, 3104, 3504, 3719], 'period': [797, 3215], 'misery': [799], 'mentioned': [804, 4311], 'among—but': [805], 'ultimately': [806, 2515], 'included': [808, 2154, 3427], 'among—those': [809], 'recipients': [812], '1994': [815, 876], 'Nobel': [816, 953, 1088, 2047], 'Prize': [817, 844, 858, 889, 1089, 2048], 'Physiology': [819, 1091], 'Medicine': [821, 1814, 3493], 'Alfred': [824], 'Gilman': [825], 'Martin': [827], 'Rodbell.': [828], 'disappointment': [830, 877], 'well': [832, 4191, 4235], 'known': [833, 1053, 2114, 2766], 'luckily': [835], 'short-lived': [836], 'soon': [838, 862], 'thereafter,': [839, 3161], '2000': [843, 857, 952, 1087], 'Arvid': [846], 'Carlsson': [847], 'Eric': [849], 'Kandel.': [850], 'Although': [851, 1432, 1721, 4207], 'gap': [853], 'brief,': [855, 956], 'could': [859, 2214, 2712, 3845, 4081], 'come': [861, 892, 1633, 4398], 'enough': [863], 'us': [870, 1192, 2876, 2901, 4169, 4619], 'aware': [873, 1338], 'years': [881, 959, 4034, 4241, 4447], 'we': [885, 1646, 4478, 4650, 4661], 'worried': [886], 'way.': [894], 'But': [895, 4585], 'did.': [897], 'Rockefeller': [902, 1509, 1557, 1746, 2607, 3190, 4350], 'University': [903, 1818, 2373, 2382, 3475, 3660, 3796, 3866], 'Yale': [905], 'age': [908, 4194, 4238], '60': [910], 'bringing': [912], 'along': [913], 'senior': [914, 2014], 'family': [917, 1270], 'members': [918], 'composed': [920], '“kitchen': [922], 'cabinet”': [923], 'consiglieri.': [925], 'Joshua': [926], 'Sanes': [927], '[1]': [928], 'Pietro': [930], 'de': [931], 'Camilli': [932], '[2]': [933], 'covered': [935], 'articles': [938, 3207, 3211], 'career': [941, 1437, 1455], 'achievements': [945], 'described': [946, 3871], 'accompanying': [950], 'Prize.': [954], 'following': [960], 'discovery': [962, 3893, 4259, 4491], 'adenylyl': [965, 1027], 'cyclase': [966, 1028], 'signaling': [967], 'system': [968, 986, 3278, 3317], 'hepatocyte': [971], 'Edwin': [973], 'Krebs': [974], 'Edmond': [976], 'Fischer,': [977], 'envisioned': [979, 1123], 'must': [982, 4637], 'similar': [985], 'brain': [989, 1026, 1621, 4504, 4558, 4583], 'neurons.': [992], 'figure': [994], 'below': [995], 'Science': [998, 1038, 1095], 'magazine': [999], 'archive': [1000], 'reproduces': [1001], 'masthead': [1003, 1033], 'cover': [1005], 'art': [1006], 'July': [1009], '4,': [1010], '1969,': [1011], 'issue': [1012, 1036, 3633, 4323], 'magazine,': [1015], 'wherein': [1016, 1875, 3220], 'reported': [1018, 1043, 2226, 2660, 3832], 'success': [1020], 'purification': [1022, 1046], 'characterization': [1024, 1890, 3009], '2)': [1030], '[3].': [1031], '1969': [1040], 'cyclic': [1048, 1165, 2498], 'AMP-dependent': [1049], 'protein': [1050, 1055, 1073, 1763, 1785, 1861, 1910, 1917, 2086, 2197, 2471, 2831, 2923, 3018, 3339, 4265], 'kinase': [1051, 1056, 1764, 1862, 2832, 3019], '(also': [1052], 'A)': [1057], 'brain.': [1059], 'This': [1060, 1255, 1594, 2843, 3566, 3632, 3713, 4130, 4520], 'beginning': [1063, 3570], "Greengard's": [1065, 3186], 'year': [1067], 'about': [1069, 1872, 2795, 4508, 4578], 'importance': [1071, 3889], 'phosphorylation': [1074, 1183, 2238, 2909, 2996, 3057], 'signal': [1076, 3140], 'transduction': [1077, 3141], 'brain,': [1080, 1107, 4554], 'Medicine.': [1093], '165,': [1096], '63-65,': [1097], '1969.': [1098], 'hurry': [1103], 'understand': [1105], 'rushed': [1110], 'second': [1115, 1141], 'messengers': [1116, 3420], 'physiological': [1119], 'effectors': [1120], 'downstream': [1125], 'third': [1126], 'fourth': [1128], 'messengers.': [1129], 'Much': [1130], 'attention': [1133], 'focused': [1134, 1717], 'steps': [1137], 'messenger': [1142], 'controlled': [1143], 'reversible': [1144, 1182], 'posttranslational': [1145], 'modification': [1146], 'addition': [1148, 3918], 'removal)': [1150], 'phosphate': [1153], 'moiety': [1154], '(i.e.,': [1155], '“phosphorylation”).': [1156], 'Synapsins': [1157], 'I': [1158, 4317], 'II': [1160], 'dopamine': [1163, 2496], 'adenosine': [1166, 2499], 'monophosphate–regulated': [1167, 2500], 'phosphoprotein': [1168, 2501], '32': [1170, 2503], 'kDa': [1171, 2504], 'among': [1173], 'famous': [1176], 'important': [1178, 1657, 3721, 4154, 4233, 4613, 4655], 'substrates': [1179], 'undergo': [1181, 1574], 'discovered': [1184, 1788], 'popularized': [1186], '[4].': [1189], 'One': [1190, 1356, 2473], '(S.G.)': [1193], 'collided': [1195], 'body': [1202, 4502], 'while': [1205, 3306, 3669, 4542], 'evolving': [1206], 'M.D.,': [1210, 1308, 1312, 1478, 1792, 2022, 2370, 2484, 2814, 3048, 3105, 3452, 3518, 4342], 'Ph.D.': [1211, 2815, 3049, 3106, 3198, 3453], 'neurologist': [1212, 1216], 'molecular': [1215, 1242, 1251, 1459, 2079, 2290, 3091], 'investigator.': [1217], 'As': [1218, 2148, 3745, 4304], "Sam's": [1219, 1301, 4017], 'neurology': [1220], 'residency': [1221, 1544], 'entering': [1223], 'penultimate': [1225], 'year,': [1226, 1545], 'apply': [1230], 'interview': [1232], 'basic': [1234], 'postdoctoral': [1235, 2488, 2780, 3513, 3647], 'fellowships,': [1236], 'mostly': [1237, 3269, 3303], 'laboratories': [1239, 1342, 2458], 'focusing': [1240, 1248], 'neurobiology': [1243], 'especially': [1245, 1447, 3720, 3988, 4386], 'neuropathogenesis': [1252], 'dementia.': [1254], 'subconsciously': [1257], 'undoubtedly': [1259], 'influenced': [1260], 'fact': [1263], 'Sam': [1265, 1360, 1539, 1693, 1722, 1742, 1868, 1876, 2181, 2225, 2567, 2818, 4006], 'raised': [1267], 'where': [1271, 1352, 1569, 1713, 3248, 3279, 3365], 'exposed': [1274], 'everyday': [1275], "Alzheimer's": [1277, 1776, 1840, 1971, 2083, 2117, 3852, 3883, 4438, 4451, 4517], 'disease,': [1278], 'paternal': [1282], 'grandmother,': [1283], 'eventually': [1284, 1293, 3976], 'maternal': [1287, 1290], 'aunt,': [1288], 'uncle,': [1291], 'own': [1296], 'mother,': [1297], 'mother-in-law,': [1298], 'father-in-law.': [1300], 'chairmen': [1302], 'program': [1304], 'directors,': [1305], 'Fred': [1306, 1358, 1416, 1433], 'Plum,': [1307], 'Jerry': [1310, 1422], 'Posner,': [1311], '(Chairs': [1313], 'Neurology': [1315, 1490, 3792], 'Neuro-Oncology': [1317], 'New': [1320, 1485, 1527, 1566], 'Memorial-Sloan': [1324, 2808], 'Kettering,': [1325, 2809], 'respectively)': [1326], 'key': [1329], 'referees': [1330], 'fellowship': [1333], 'applications,': [1334], 'several': [1341, 1441, 1599, 4060], 'Northeast,': [1345], 'Midwest,': [1346], 'West': [1348, 2310, 2410], 'Coast': [1349], 'US': [1350], 'regions': [1351], 'applied.': [1355], 'called': [1359, 1786], 'office': [1363], 'and,': [1364, 3557], 'without': [1365, 3579, 4402], 'looking': [1366], 'keyboard,': [1370], 'usual': [1374], 'curt': [1375], 'manner,': [1376], '“Sam:': [1377], 'you': [1378, 4319], 'should': [1379], 'Greengard.': [1382, 3119, 3435], 'has': [1384, 2522, 3714, 3750, 4521, 4617], 'best': [1386, 1414, 1690, 2530, 4632], 'track': [1387, 4674], 'world': [1393], 'training': [1395], 'new': [1396, 2788, 4230], 'neuroscience': [1397, 4172], 'heads': [1399, 3261], 'can': [1401, 3534], 'compete': [1402], 'succeed': [1404], 'National': [1407, 2034, 2231], 'Institutes': [1408], 'Health': [1410, 3820], 'journals.”': [1415], 'resumed': [1417], 'typing,': [1419], 'once': [1421], 'weighed': [1423], 'in,': [1424], 'decision': [1426], 'essentially': [1428], 'fait': [1430], 'accompli.': [1431], 'decades': [1442, 1939], 'earlier,': [1443], "Jerry's": [1444], 'input': [1445], 'timely': [1448], 'because,': [1449], 'same': [1452, 2797, 2897], 'moment,': [1453], 'unraveling': [1457], 'mechanisms': [1460], 'underlying': [1461], 'paraneoplastic': [1462], 'disorders': [1463], 'gaining': [1465], 'momentum,': [1466], 'close,': [1470], 'enthusiastic,': [1471], 'still-ongoing': [1473], 'collaboration': [1474, 1874, 3462], 'Robert': [1476, 1499], 'Darnell,': [1477], 'Ph.D.,': [1479, 1793, 1822, 2008, 2288, 2379, 2801, 3100, 3466, 3510, 3591, 3783, 3863], 'product': [1482], 'Hospital-Cornell-Memorial-Sloan-Kettering': [1487], 'Cancer': [1488, 1505], 'Residency': [1491], 'Program': [1492], 'went': [1494, 2903], 'become': [1497, 2624], 'Harriet': [1501], 'Heilbrunn': [1502], 'Professor': [1503, 1796, 1827, 2803, 3467, 3790, 4343], 'Biology': [1506, 2806], 'University,': [1510, 1747, 1802, 2608, 3602, 4351], 'investigator': [1512], 'Howard': [1515], 'Hughes': [1516], 'Institute,': [1518], 'Founding': [1521], 'Director': [1522, 1836, 3801], 'CEO': [1524], 'Genome': [1529], 'Center.': [1530], 'Soon': [1531, 2447, 3160], 'accepting': [1533], 'position': [1535], 'Paul,': [1537, 2413, 4026, 4352], 'finishing': [1541], 'chief': [1543], 'paged': [1547], 'him': [1548, 1551, 1750, 4077], 'asked': [1550, 2817, 4070], 'meet': [1553], 'hospital': [1562, 1568], 'preparing': [1572], 'biopsy': [1575], '“hot': [1580], 'spots”': [1581], 'spine': [1584], 'ribs': [1586], 'suspicious': [1589], 'cancer': [1591], 'tuberculosis.': [1593], 'health': [1600], 'scares': [1601], 'face': [1605], 'defeat': [1607], 'over': [1608, 3213, 3617, 3774, 4019, 4032], 'ensuing': [1610], 'decades;': [1611], 'myocardial': [1612], 'infarction,': [1613], 'dengue': [1614], 'fever,': [1615], 'transthyretin': [1616], 'amyloidosis': [1617, 3847, 4467], 'peripheral': [1618], 'neuropathy,': [1619], 'traumatic': [1620], 'injury,': [1622], 'surgically': [1625], 'evacuated': [1626], 'subdural': [1627], 'hematoma': [1628], 'are': [1629, 3387, 3415, 4651, 4658, 4662, 4671], 'mind.': [1635, 4206], 'Each': [1636], 'entered': [1640], '70s,': [1642, 4225], '80s,': [1643], '90s,': [1645], 'feared': [1647], 'events': [1652, 3426], 'set': [1654, 2417, 4644], 'off': [1655, 3043], 'decline': [1658], 'intellect': [1661, 4181], 'cognitive': [1663, 4540], 'skills,': [1664], 'end,': [1668, 1925], 'remained': [1670, 2523], 'intact,': [1671], 'sparkle': [1674], 'eyes': [1677], 'hyperverbal': [1680], 'childlike': [1681], 'affect': [1682], 'is': [1684, 1833, 2743, 2764, 3224, 3234, 3309, 3370, 3380, 3403, 3554, 3564, 4288, 4383, 4423, 4463, 4468, 4474, 4565], 'displayed': [1687], 'scientists.': [1691], 'joined': [1694, 4025], 'summer': [1699, 4162], '1986,': [1701, 1960], 'keen': [1704], 'move': [1706], 'more': [1708, 1738, 4425], 'clinically': [1709, 4232, 4403], 'relevant': [1710], 'directions': [1711, 4442], 'then.': [1720], 'wanted,': [1724], 'beginning,': [1727], 'contribute': [1729], 'redirection': [1732], 'effort': [1735, 2597], 'translational': [1739], 'direction,': [1740], 'assigned': [1749], 'already': [1754, 2042, 4310], 'progress,': [1756], 'purifying': [1759], '“180-kD”': [1761], 'calcium-/calmodulin-dependent': [1762], 'substrate': [1765, 2994], 'highly': [1766, 2217, 2512], 'enriched': [1767], 'postsynaptic': [1769], 'densities.': [1770], 'moment': [1773, 4512], 'area,': [1777], 'much': [1780], 'interest': [1781], 'directed': [1782], 'toward': [1783, 3262, 3272, 4163], 'Alz50,': [1787], 'Ben': [1790, 1848, 1880, 1897], 'Wolozin,': [1791], '(now': [1794, 3177], 'Neuroscience': [1798, 1955, 3471], 'Boston': [1801, 3526], 'Albert': [1810], 'Einstein': [1811, 1831], 'School': [1812], 'Yeshiva': [1817], 'Peter': [1820, 1850, 2179, 2256], 'Davies,': [1821], 'Biochemistry': [1829], 'now': [1834, 2765, 3225, 3904, 4636], 'Litwin-Zucker': [1839], 'Hofstra-Northwell': [1844], 'Hospital': [1845, 3524], 'School).': [1847], 'intriguing': [1854], 'Alz50': [1857, 1902, 1914], 'associated': [1859, 2337, 3905], 'catalytic': [1863, 1894, 2219], 'activity,': [1864], 'approached': [1870], 'them': [1871, 2425, 4611], "Peter's": [1882], 'four': [1886, 1945, 3205], 'conduct': [1888], 'further': [1889], 'Alz50.': [1892], 'activity': [1895, 3844], 'observing': [1899], 'preparations': [1903], 'turned': [1904, 2848, 2866, 3715], 'out': [1905, 2418, 2849, 2867, 3616, 3716, 4123], 'contaminating': [1909], 'kinase,': [1911], 'dissociable': [1912], 'using': [1915, 2192, 3138, 4525], 'standard': [1916, 3139, 3228], 'chromatography': [1918], 'methods.': [1919], 'That': [1920, 3039], 'disappointing': [1923], 'dead': [1924], 'within': [1927], 'weeks,': [1928], 'appeared': [1930, 2352], 'even': [1932, 3578, 4410, 4424], 'stronger': [1933], 'lead': [1934, 3536], 'consume': [1937], '3': [1938], 'careers': [1942], 'all': [1944, 4092, 4124, 4127, 4549], 'men.': [1946], 'Annual': [1949], 'Meeting': [1950], 'Society': [1953], 'fall': [1958, 4165], 'audience': [1962], 'listening': [1964], 'opening': [1967], 'slide': [1972, 1982], 'chair': [1976, 2820], 'announced': [1977], 'special': [1980], 'additional': [1981], 'talk': [1983], 'added': [1986], 'run': [1992], '15': [1993], 'late': [1995, 2121, 4161], 'accommodate': [1997], 'emergency': [1999], 'add-on.': [2000], 'Dmitry': [2006, 2063, 2107, 2153, 2254, 3589], 'Goldgaber,': [2007, 3590], 'fellow': [2011], 'abstract,': [2018], 'D.': [2019], 'Carleton': [2020], 'Gajdusek,': [2021], 'head': [2025, 2790], 'neurodegenerative': [2029], 'disease': [2030, 4518], 'unit': [2031], 'Institute': [2035], 'Neurological': [2037], 'Disorders': [2038], 'Stroke': [2040], 'winner': [2044], 'kuru': [2053], 'transmissibility.': [2054], 'abuzz': [2058], 'anticipation,': [2060], 'spoke,': [2064], 'revealed': [2066], 'team': [2071, 2570, 2881, 3449, 4356], "Gajdusek's": [2073], 'succeeded': [2076, 4546], 'cloning': [2080, 2441], 'amyloid': [2084], 'precursor': [2085], '(APP)': [2087], 'assignment': [2090], 'chromosome': [2092], '21,': [2093], 'significance': [2095], 'lost': [2099], 'no': [2101, 2456, 3752, 4475], '[5].': [2106], 'strongly': [2108], 'implied': [2109], 'persons': [2111], 'predisposition': [2115], 'pathology': [2118], 'complication': [2122], 'trisomy': [2124], '21': [2125], '(Down': [2126], 'syndrome)': [2127], 'almost': [2128, 4289], 'certainly': [2129, 4290], 'suffering': [2131], 'way': [2134, 4633], 'harbored': [2137], 'extra': [2139], 'copy': [2140], 'APP': [2143, 2159, 2241, 2345, 2395, 2403, 2468, 2509, 2543, 2551, 2565, 2632, 2672, 2707, 2728, 2770, 2856, 2880, 2912, 2990, 3059, 3233, 3260, 3293, 3308, 3356, 3424, 3541, 3607, 3630, 3693, 3900, 4495], 'gene': [2144], '(a': [2145, 4262], '“genetic': [2146], 'overdose”).': [2147], 'luck': [2149], 'it,': [2152], 'transcript': [2156], 'amino': [2160, 2391], 'acid': [2161, 2392, 3349], 'sequence': [2162, 2175, 2349, 2393], 'Christmas': [2165, 2251, 2588], 'card': [2166, 2252], 'sent': [2169], 'Peter,': [2171], 'Sam,': [2177, 2412], 'whereupon': [2178], 'immediately': [2182], 'spied': [2183], 'potential': [2184, 2211], 'phosphoacceptor': [2185, 2212], 'serine,': [2186], 'threonine,': [2187], 'tyrosine': [2189], 'sites,': [2190], 'battery': [2194], 'purified': [2196], 'kinases': [2198, 2924], 'accumulated': [2199], 'laboratory,': [2202, 3652], 'able': [2205, 2316, 4481], 'rapidly': [2207], 'demonstrate': [2208], 'sites': [2213, 2719], 'function': [2215], 'favorable': [2218], 'efficiencies.': [2220], '1988,': [2222], 'proceedings': [2228], 'Academy': [2232], 'Sciences': [2234], 'direct': [2237, 3056], 'cytoplasmic': [2242, 2633, 2722, 2913, 2977, 3073], 'tail': [2243, 2634, 2978, 3074], 'sequences': [2244], '1986': [2250, 2587], '[6].': [2257], 'PNAS': [2259, 2888, 3206], 'article': [2260, 2359, 2889, 3494], 'Gandy': [2262, 3083, 3489, 3665, 4007], 'et': [2263], 'al.': [2264], '(1988)': [2265], 'served': [2266], 'definite': [2269], 'declaration': [2270], 'trajectory': [2273], 'mind,': [2278], 'only': [2282, 2916, 2987, 3096, 4626], 'contributions': [2284, 2935], 'Axel': [2286, 2323], 'Unterbeck,': [2287, 2363, 3079], 'biologist': [2291], 'moved': [2294], 'Benno': [2296], "Muller-Hill's": [2297], 'Germany': [2300], 'Molecular': [2302], 'Therapeutics,': [2303], 'Inc.,': [2304], 'Bayer': [2307], 'campus': [2308], 'Haven,': [2311, 2411], 'research': [2314, 3113], 'take': [2318], 'flight.': [2319], 'Germany,': [2322], 'supervisor': [2327], 'Jie': [2332], 'Kang,': [2333, 2362], '“Kang': [2340, 2401], 'sequence”,': [2341, 2402], 'full-length': [2344], 'clone': [2346, 2495], 'Nature': [2354, 3492], '1987': [2356], 'coauthored': [2360], 'Muller-Hill,': [2364], 'collaborators': [2367], 'Colin': [2368, 2655], 'Masters,': [2369, 2656], 'Melbourne': [2375], 'Konrad': [2377, 2658], 'Beyreuther,': [2378], 'Heidelberg': [2384], '[7].': [2385], 'Now,': [2386], 'armed': [2387], 'complete': [2390], 'bit': [2399], 'cDNA': [2404, 2552], 'brought': [2406, 3172, 3953], 'Unterbeck': [2408], 'colleagues': [2416, 2701, 3831], 'develop': [2420, 2554], 'antibodies': [2421, 2531, 2668], 'enable': [2424, 3295], '(and': [2426, 2594, 3502], 'others)': [2427], 'answer': [2431], 'burning': [2434], 'cell': [2435, 2965], 'biological': [2436], 'questions': [2437, 4642], 'posed': [2438], 'chromosomal': [2443], 'localization': [2444], 'APP.': [2446], 'literature': [2449], 'devolved': [2450], 'undecipherable': [2453], 'mess': [2454], 'making': [2459, 3263, 3971, 4132], 'consistent': [2461], 'claims': [2462], 'having': [2464, 3580], 'demonstrated': [2465, 3032], 'endogenous': [2466], 'human': [2467, 2542, 2550, 2564, 2671, 3756], 'level.': [2472], 'helped': [2477], 'overcome': [2478], 'problem': [2480], 'Michelle': [2482], 'Ehrlich,': [2483, 3078], 'researcher': [2489, 2781, 3514], 'designed,': [2506], 'project,': [2510], 'labor-intensive': [2513], 'strategy': [2517, 3573], 'screening': [2519], 'since': [2524], '1990': [2525], 'reacts': [2533], 'high': [2535, 2538], 'avidity': [2536], 'affinity': [2539], 'APP-like': [2545], 'protein-2.': [2546], 'Ehrlich': [2547], 'used': [2548, 2571, 3086, 3124], "Unterbeck's": [2549], 'vitro': [2557], 'transcription/translation': [2558], 'assay': [2559, 3170], 'generated': [2561, 3076], '[35S]methionine-labeled,': [2562], 'authentic': [2563], 'screen': [2573], 'sera': [2574], 'dozens': [2576], 'rabbits': [2578], 'vaccinated': [2579], 'peptides': [2581], 'based': [2582, 2951, 4453], 'again': [2583], 'Goldgaber/Davies': [2586], 'card.': [2589], 'Out': [2590], 'heroic': [2593], 'somewhat': [2595, 2703], 'frantic)': [2596], 'conducted': [2601], 'emerged': [2610, 3212, 4212], 'useful': [2613, 2627, 2667, 3737], 'antibody': [2614, 2629, 3075, 3127], 'named': [2615, 3108], '“369”': [2616], '“secret': [2620], 'sauce”': [2621], 'necessary': [2622], 'precipitating': [2628], 'against': [2630, 2669], '[8]': [2635], '(“369”': [2636], "rabbit's": [2639], 'cage': [2640], 'number).': [2641], 'need': [2643, 4414, 4569], 'reagent': [2648], 'became': [2649, 3964], 'acutely': [2650], 'Andreas': [2653], 'Weidemann,': [2654], 'Beyreuther': [2659], 'developed': [2666], 'extracellular': [2673], 'domain': [2674, 3369], 'gone': [2679], 'discover': [2682, 2906], 'apparently': [2683, 3535, 4515], 'large': [2686], 'ectodomain': [2687, 2729, 3250, 3552], 'excised': [2690], 'released': [2692, 2731], 'bodily': [2694], 'fluids.': [2695], 'Initially,': [2696], 'Andreas,': [2697], 'Colin,': [2698], 'Konrad,': [2699], 'stymied': [2704], 'describing': [2706], 'metabolism': [2708], 'completely': [2709], 'detect': [2714], 'determine': [2716], 'cleavage': [2718, 3297, 3375, 3547, 3701, 3901], 'stubs': [2723], 'behind': [2725], 'later': [2735], 'dubbed': [2736], '“shedding”': [2738], 'proteolytic': [2741], 'event': [2742, 2748, 2961], 'local': [2745], 'plasma': [2746, 3363, 3544], 'membrane–localized': [2747], 'attributable': [2749], 'disintegrin': [2753], 'metalloproteinase': [2755], '(ADAM)10': [2756], 'protease.': [2757], 'identification': [2759, 3921], 'ADAM10': [2761, 3406, 3768, 3838], 'basal': [2769, 3408], 'α-secretase': [2771, 2835, 2857, 3374, 3700, 3769, 3843, 3903], 'made': [2773, 3404], 'Joseph': [2775, 3098, 3121, 3784], 'Buxbaum,': [2776, 3099, 3319, 3432, 3910], 'former': [2778, 4532], 'who,': [2782], 'Mount': [2792], 'Sinai.': [2793], 'Joan': [2799], 'Massague,': [2800], 'Marcus': [2811], 'Bosenberg,': [2812], 'student,': [2816, 3050], "Bosenberg's": [2821], 'thesis': [2822, 3112], 'defense': [2823], 'ADAM17': [2826, 3377, 3549], 'identified': [2828, 3581], 'C': [2833], '(PKC)-regulated': [2834], '“sheddase”': [2837, 2845], 'protransforming': [2839], 'growth': [2840], 'factor-alpha': [2841], '(pro-TGFα).': [2842], 'regulated': [2844, 2855], 'TGFα': [2847, 2864], 'identical': [2852, 3392], '[9].': [2858], '“Regulated,”': [2859], 'case': [2862], 'shedding,': [2865], 'mean': [2869], '“regulated': [2870], 'PKC,”': [2872], 'resonated': [2874], 'our': [2883, 4388], 'report': [2884], '1988': [2887, 3217], 'implicated': [2891, 4266], 'PKC': [2892, 2918, 2948, 2998, 3331, 3379, 3533, 3605, 3621, 3627, 3672, 3682, 3691, 3706, 3729, 3766, 3898], '[6],': [2893, 3157], '[8].': [2894], 'Along': [2895], 'line,': [2898], '(T.S.)': [2902], 'efficient': [2908], 'tail,': [2914], 'cyclin-dependent': [2922], '(cdc2': [2925], 'cdk5)': [2927], '[10],': [2928], '[11].': [2929], 'So': [2930], 'recap': [2932], 'authors': [2938], 'comment,': [2941], 'S.G.': [2942, 3117], 'predicted': [2944], 'involvement': [2946], '(on': [2949], 'Ser655)': [2950], 'short': [2953], 'peptide': [2954], 'model': [2955, 2966], 'substrates,': [2956], 'T.S.': [2958, 3031, 3045], 'confirmed': [2959], 'permeabilized': [2964], 'incubated': [2967], '[35S]methionine,': [2969], 'lysed': [2970], 'immunoprecipitated': [2972], '369': [2975, 3071, 3126], 'anti-APP': [2976, 3072], 'antibody.': [2979], "T.S.'s": [2981], 'hands,': [2982], 'expect,': [2986], 'fully': [2988], 'mature': [2989, 3259], 'apparent': [2993], 'Ser655': [3000], '[12].': [3001], 'cdk5': [3002], 'days': [3007], 'original': [3017], 'panel': [3020], 'tested': [3021], 'S.G.,': [3023], 'enzyme': [3027, 3284, 4526], 'purified,': [3030], 'ability': [3034], 'efficiently': [3036], 'phosphorylate': [3037], 'Thr668.': [3038], 'spun': [3042], 'Masaki': [3051], 'Oishi': [3052], '[10].': [3053], 'While': [3054], 'elucidated': [3062], 'Suzuki,': [3064, 3909], 'Gandy,': [3065, 3320, 3433, 3459, 3908], 'Czernik,': [3066], 'Nairn,': [3067], 'Greengard,': [3069, 3081, 3457, 3487, 3907], 'Ramabhdran,': [3080], 'metabolic': [3088, 3134, 3326], 'labeling': [3089, 3135], 'vesicle': [3092, 3143, 3168], 'transport': [3093, 3353], 'biology': [3094, 3144], 'Gregg': [3109, 3123], 'Caporaso': [3110], 'cosupervized': [3115], 'Both': [3120], 'protocol': [3130], 'pulse-chase': [3132], '[35S]': [3133], 'pretreatment': [3137], 'reagents': [3145], 'phorbol': [3148, 3333], 'esters,': [3149], 'okadaic': [3150], 'acid,': [3151], 'chloroquine,': [3152], 'brefeldin': [3153], 'A,': [3154], 'monensin': [3156], '[8],': [3158], '[13].': [3159], 'novel': [3163, 4264, 4363, 4571], '[35S]O4-labeling': [3164], 'trans-Golgi': [3165], 'network': [3166], '(TGN)': [3167], 'budding': [3169], 'Gandy-Greengard': [3175], "Gandy's": [3180], 'independent': [3181, 3505], 'University)': [3191], 'through': [3192], 'recruitment': [3194], 'Huaxi': [3196], 'Xu,': [3197, 3486], '[14].': [3199], 'various': [3201], 'combinations': [3202], 'authors,': [3204], 'JBC': [3210], '1992,': [3219], 'defined': [3222], 'considered': [3226, 4144], 'canonical': [3229], 'fate': [3230], 'APP:': [3232], 'synthesized': [3235], 'inserted': [3237], 'endoplasmic': [3240], 'reticulum': [3241], 'membrane': [3242, 3364, 3545], 'cotranslationally,': [3243], 'matures': [3244], 'Golgi': [3247], 'undergoes': [3251], 'N-': [3252], 'O-glycosylation': [3254], 'tyrosyl': [3256], 'sulfation.': [3257], 'Fully': [3258], 'exit': [3265], 'TGN': [3268, 3360], 'intact': [3270, 3355], 'entrance': [3274], 'endocytic': [3277, 3316], 'encounters': [3281], 'β-APP-site–cleaving': [3283], '(BACE1).': [3285], 'pathogenic': [3287, 3835], 'mutations': [3288], 'Swedish': [3291], 'mutant': [3292], '(APPK670N/M671L)': [3294], 'BACE1': [3299, 3313], 'TGN-localized': [3304], 'event,': [3305], 'wild-type': [3307], 'cleaved': [3311], '[15].': [3318], 'showed': [3323, 3528, 3603], 'consequence': [3327], 'activation': [3329, 3628, 3673, 3683], 'esters': [3334], 'inactivation': [3337, 3686], 'phosphatases': [3340], '1': [3341], '2A': [3343], '(PP1': [3344], 'PP2A)': [3346], 'Okadaic': [3348], 'enhancement': [3351], 'holoprotein': [3357], 'amyloid-β': [3367], '(Aβ)': [3368], 'destroyed': [3371], 'via': [3372], 'activated': [3373], 'stimulated': [3381], 'PP1': [3384], 'PP2A': [3386, 3414], 'inactivated.': [3388], 'Cleavage': [3389], 'intra-Aβ': [3393], 'site': [3394], 'lysine': [3396], '16': [3397], 'leucine': [3399], '17': [3400], 'Aβ': [3402, 3562, 3576, 3624, 3675, 3708, 3743, 4505, 4551], 'conditions': [3409], 'PKC,': [3411], 'PP1,': [3412], 'stimulated.': [3417], 'linked': [3421], 'processing': [3425], 'acetylcholine': [3428], '(discovered': [3429], 'concurrently': [3430], '[16]': [3436], 'Nitsch': [3439], 'Wurtman': [3441], '[17]': [3442], '17-beta-estradiol': [3444], '(described': [3445], 'led': [3450], 'Ari': [3455], 'Jaffe,': [3456], 'Dominque': [3464], 'Toran-Allerand,': [3465], 'Anatomy': [3469], 'Columbia': [3474], 'College': [3476], 'Physicians': [3478], 'Surgeons,': [3480], 'greatest': [3483], 'detail': [3484], '1995': [3496], '[18]).': [3497], 'Buxbaum': [3498], '[19]': [3501], 'concurrent': [3506], 'study,': [3507, 3827, 3857], 'Christian': [3508], 'Haass,': [3509], 'Dennis': [3516], 'Selkoe,': [3517], 'Brigham': [3521], "Women's": [3523], '[20])': [3527], 'acute': [3530, 3560, 3670, 4426], 'hyperactivation': [3531], 'enhanced': [3538, 3556], 'relocation': [3539], 'shedding': [3553], 'dramatically': [3555], 'setting,': [3561], 'generation': [3563, 3577, 3625, 3709], 'reduced.': [3565], 'looked': [3567], 'reducing': [3575], 'proteases': [3583], 'responsible': [3584], 'generation.': [3587, 3744], 'professor': [3595], 'psychiatry': [3597], 'Stony': [3600], 'Brook': [3601], 'activates': [3606], 'transcription': [3608, 3694], '[21],': [3609], 'raising': [3610], 'question': [3612], 'wins': [3615], 'long': [3619], 'haul:': [3620], 'reduction': [3622, 4499], 'transcription.': [3631], 'solved': [3635], 'Portugal': [3637], 'Odete': [3639], 'Edgar': [3641], 'da': [3642, 3913], 'Cruz': [3643, 3914], 'e': [3644, 3915], 'Silva': [3645], '(former': [3646], 'researchers': [3648], 'professors': [3657], 'Aveiro)': [3662], 'worked': [3663], 'show': [3667], 'short-term': [3671], 'reduced': [3674], 'generation,': [3676], 'feared,': [3680], 'long-term': [3681], 'PP1/PP2A': [3685], 'causes': [3687], 'effect': [3689, 3698, 4537], 'overtake': [3696], 'chronic': [3705, 4582], 'activation,': [3707], 'increases': [3710], 'enormously': [3711], '[22].': [3712], 'point': [3722], 'investigators': [3725], 'proposed': [3727], 'modulatory': [3730], 'drugs': [3731], 'bryostatin': [3734, 3749], 'therapeutic': [3740], 'modulation': [3741], 'writing,': [3748], 'shown': [3751], 'meaningful': [3753, 4404, 4488], 'benefit': [3754], 'clinical': [3757], 'trials.': [3758], 'Two': [3759], '“open': [3762], 'loops”': [3763], 'stories': [3770], 'closed': [3773], '5': [3777], 'yrs': [3778, 4391], 'Rudolph': [3780], 'E.': [3781], 'Tanzi,': [3782], 'P.,': [3785], 'Rose': [3787], 'F.': [3788], 'Kennedy,': [3789], 'Harvard': [3795], 'Vice-Chair': [3798], 'Neurology,': [3800], 'Genetics': [3804], 'Aging': [3806], 'Research': [3807], 'Unit,': [3808], 'Co-Director': [3810], 'Henry': [3813], 'Allison': [3815], 'McCance': [3816], 'Brain': [3819], 'Massachusetts': [3822], 'General': [3823], 'Hospital.': [3824], '“Rudy”': [3828], 'mutation': [3836, 3875, 4496], '[23],': [3839], 'indicating': [3840], 'impaired': [3842], 'foster': [3846], 'enhance': [3849], 'susceptibility': [3850], 'disease.': [3853, 3884], 'separate': [3856], 'Rudy': [3858], 'collaborator': [3860], 'Alexandra': [3861], 'Newton,': [3862], 'California,': [3868], 'San': [3869], 'Diego,': [3870], 'association': [3872], 'PKCα': [3877], '[24]': [3878], 'increased': [3880], 'risk': [3881], 'discoveries': [3886], 'cement': [3887], 'breakthrough': [3892, 4360], 'role': [3896], 'Silvas.': [3916], 'quintessential': [3924], 'scientist,': [3925], 'perpetuator': [3930], 'consumer': [3933], 'wit.': [3935], 'loved': [3937, 3942], 'laugh,': [3939], 'make': [3944], 'others': [3945], 'laugh.': [3946], 'abrupt': [3955], 'student-orator': [3959], 'reading': [3960], 'aloud': [3961], 'too': [3965], 'weary': [3966], 'tongue-tied': [3968], 'avoid': [3970], 'hilarious': [3972], 'misspeaks': [3973], 'break': [3977, 4229], 'skills': [3980], 'concentration': [3982], 'amused': [3989], 'particular': [3992], 'malapropism': [3993], 'delivered': [3994], 'minister': [3997], 'pulpit': [4000], 'witnessed': [4004], 'mother': [4010, 4018], 'related': [4013, 4074], 'Thanksgiving': [4021], 'dinner': [4022], 'Ursula,': [4027], 'families': [4031], '20': [4033], 'ago.': [4035], 'thoroughly': [4041], 'still': [4045, 4056, 4174, 4244], 'recalling': [4046], 'retelling': [4048], 'weeks': [4051], 'before': [4052], 'death': [4054], 'laughing': [4057], 'minutes.': [4061], 'story,': [4067], 'back': [4075], 'enjoy': [4082], 'alternatively': [4083], 'joker': [4086], 'joke': [4089], 'consumer.': [4090], 'Not': [4091], 'sweetness': [4094], 'light.': [4096], 'bete': [4098], 'noir': [4099], 'lighter': [4102], 'side': [4103], 'ruthlessly': [4106], 'competitive': [4107], 'alter': [4108], 'ego.': [4109], 'wanted': [4112], 'win': [4114], 'priorities': [4116], 'stake,': [4119], 'pulled': [4122], 'stops,': [4126], 'meant': [4131], 'enemies': [4134], '(or,': [4135], 'quite': [4136], 'enemies,': [4139], 'fact),': [4141], 'cost': [4150], 'working': [4152], 'areas.': [4155], 'present—in': [4159], '2019—many': [4167], 'community': [4173], 'mourn': [4175], 'loss': [4177], 'functioned': [4183], 'uppermost': [4186], 'margins': [4187], 'productivity': [4189], 'consider': [4198], 'retirement.': [4199], 'Voluntary': [4200], 'retirement': [4201], 'recognized': [4210, 4219], 'midlife': [4217], 'continued': [4227], 'ground': [4234], '90': [4240], 'productive': [4245, 4614], 'sudden': [4251], 'demise.': [4252], 'Space': [4253], 'precludes': [4254], 'description': [4255], 'recent': [4258], 'p65': [4261], 'etiology': [4269], 'pharmacotherapy': [4271], 'mood': [4273], 'disorders)': [4274], 'founding': [4277], 'biotechnology': [4280], 'company': [4281], 'Intra-Cellular': [4282], 'Therapies': [4283], 'Inc.': [4284], '(whose': [4285], 'drug': [4286], 'ITI-007': [4287], 'destined': [4291], 'Food': [4294], 'Drug': [4296], 'Administration': [4297], 'approval': [4298], 'use': [4300], 'psychotic': [4302], 'disorders).': [4303], 'if': [4305, 4649, 4660], 'breadth': [4307], 'depth': [4309], 'here': [4312], 'sufficiently': [4315], 'awe-inspiring,': [4316], 'refer': [4318], 'June': [4321], '2019': [4322], 'Neuron': [4325], 'hit': [4327], 'newsstands': [4329], 'week': [4331], 'death.': [4334], 'article,': [4337], 'together': [4338], 'Jeffrey': [4340], 'Friedman,': [4341], 'Head': [4345], 'Laboratory': [4347], 'Jeff,': [4353], 'describe': [4357], 'elucidating': [4362], 'pathways': [4364], 'linking': [4365], 'dopamine,': [4366], 'satiety,': [4367], 'obesity.': [4369], 'direction': [4372], 'gaze,': [4375], 'genius': [4377], 'evident': [4379], 'piercing.': [4381], 'sorely': [4384], 'missed,': [4385], '40': [4390, 4446], '“molecular': [4394], 'era': [4395], 'dementia”': [4397], 'close': [4401], 'disease-modifying': [4405], 'interventions': [4406, 4579], 'hand': [4408], 'sight.': [4412], 'critical': [4416, 4605], 'thinking': [4417, 4577], 'scientists': [4419], 'realm': [4429], 'strategic': [4431], 'planning': [4432], 'and/or': [4433], 'policy': [4434, 4587], 'formulation': [4435], 'field': [4439], 'regarding': [4440], 'future': [4441], 'research.': [4444], 'Specifically,': [4445], 'R&D': [4449, 4595], 'therapy': [4452], 'prevailing': [4455], 'ideas': [4456], 'theories': [4458], 'failed': [4460], 'us.': [4461], 'strong': [4464], 'frequent': [4470], 'instigator,': [4471], 'will': [4479], 'exploit': [4483], 'observation': [4485], 'intervention.': [4489], 'Icelandic': [4494], 'shows': [4497], 'whole': [4501], 'levels': [4506], '50%': [4509], 'conception': [4514], 'prevents': [4516], '[25].': [4519], 'fueled': [4522], 'prevention': [4523], 'strategies': [4524], 'inhibitors': [4527], 'antiamyloid': [4529], 'antibodies.': [4530], 'unfortunate': [4536], 'accelerating': [4539], 'decline,': [4541], 'latter': [4544], 'purging': [4548], 'detectable': [4550], 'Aβ-free': [4557], 'continues': [4559], 'fail': [4561, 4600], 'schedule.': [4563], 'unmet': [4568], 'conceptual': [4572], 'models,': 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1}], 'updated_date': '2024-12-11T21:10:42.727187', 'created_date': '2019-09-26'}
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