PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury

Name: Work Video:
Duration: 3 min 30 s
Description: Is tau load associated with long-term outcomes of TBI? By using PET to assess tau deposits in patients with chronic TBI, Takahata et al. reveal elevated tau load compared to age-matched controls, and show that the abundance of tau in white matter is associated with late-onset neuropsychiatric symptoms.
Keisuke Takahata; Yasuyuki Kimura; Naruhiko Sahara; Shunsuke Koga; Hitoshi Shimada; Masanori Ichise; Fumie Saito; Sho Moriguchi; Soichiro Kitamura; Manabu Kubota; Satoshi Umeda; Fumitoshi Niwa; Jin Mizushima; Yoko Morimoto; Michitaka Funayama; Hajime Tabuchi; Kevin F. Bieniek; Kazunori Kawamura; Ming-Rong Zhang; Dennis W. Dickson; Masaru Mimura; Motoichiro Kato; Tetsuya Suhara; Makoto Higuchi
{'id': 'https://openalex.org/W2972919080', 'doi': 'https://doi.org/10.1093/brain/awz238', 'title': 'PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury', 'display_name': 'PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury', 'publication_year': 2019, 'publication_date': '2019-07-24', 'ids': {'openalex': 'https://openalex.org/W2972919080', 'doi': 'https://doi.org/10.1093/brain/awz238', 'mag': '2972919080', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31504227'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/brain/awz238', 'pdf_url': 'https://academic.oup.com/brain/article-pdf/142/10/3265/30063875/awz238.pdf', 'source': {'id': 'https://openalex.org/S118357697', 'display_name': 'Brain', 'issn_l': '0006-8950', 'issn': ['0006-8950', '1460-2156'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/brain/article-pdf/142/10/3265/30063875/awz238.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5009790212', 'display_name': 'Keisuke Takahata', 'orcid': 'https://orcid.org/0000-0002-0884-4924'}, 'institutions': [{'id': 'https://openalex.org/I4210114217', 'display_name': 'National Institutes for Quantum and Radiological Science and Technology', 'ror': 'https://ror.org/020rbyg91', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114217']}, {'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Keisuke Takahata', 'raw_affiliation_strings': ['Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210114217']}, {'raw_affiliation_string': 'Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036744590', 'display_name': 'Yasuyuki Kimura', 'orcid': 'https://orcid.org/0000-0002-7927-9483'}, 'institutions': [{'id': 'https://openalex.org/I4210114217', 'display_name': 'National Institutes for Quantum and Radiological Science and Technology', 'ror': 'https://ror.org/020rbyg91', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114217']}, {'id': 'https://openalex.org/I4210160102', 'display_name': 'National Center for Geriatrics and Gerontology', 'ror': 'https://ror.org/05h0rw812', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160102']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasuyuki Kimura', 'raw_affiliation_strings': ['Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'National Center for Geriatrics and Gerontology, Aichi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210114217']}, {'raw_affiliation_string': 'National Center for Geriatrics and Gerontology, Aichi, Japan', 'institution_ids': ['https://openalex.org/I4210160102']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013804286', 'display_name': 'Naruhiko Sahara', 'orcid': 'https://orcid.org/0000-0003-2122-5797'}, 'institutions': [{'id': 'https://openalex.org/I4210114217', 'display_name': 'National Institutes for Quantum and Radiological Science and Technology', 'ror': 'https://ror.org/020rbyg91', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114217']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naruhiko Sahara', 'raw_affiliation_strings': ['Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210114217']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009821300', 'display_name': 'Shunsuke Koga', 'orcid': 'https://orcid.org/0000-0001-8868-9700'}, 'institutions': [{'id': 'https://openalex.org/I4210146710', 'display_name': 'Mayo Clinic in Florida', 'ror': 'https://ror.org/03zzw1w08', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210146710']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shunsuke Koga', 'raw_affiliation_strings': ['Department of Neuroscience, Mayo Clinic, Jacksonville, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Mayo Clinic, Jacksonville, USA', 'institution_ids': ['https://openalex.org/I4210146710']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069308721', 'display_name': 'Hitoshi Shimada', 'orcid': 'https://orcid.org/0000-0002-7139-7178'}, 'institutions': [{'id': 'https://openalex.org/I4210114217', 'display_name': 'National Institutes for Quantum and Radiological Science and Technology', 'ror': 'https://ror.org/020rbyg91', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114217']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hitoshi Shimada', 'raw_affiliation_strings': ['Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210114217']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103095045', 'display_name': 'Masanori Ichise', 'orcid': 'https://orcid.org/0000-0003-4216-6976'}, 'institutions': [{'id': 'https://openalex.org/I4210114217', 'display_name': 'National Institutes for Quantum and Radiological Science and Technology', 'ror': 'https://ror.org/020rbyg91', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114217']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masanori Ichise', 'raw_affiliation_strings': ['Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210114217']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112287698', 'display_name': 'Fumie Saito', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fumie Saito', 'raw_affiliation_strings': ['Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039702191', 'display_name': 'Sho Moriguchi', 'orcid': 'https://orcid.org/0000-0001-7536-9708'}, 'institutions': [{'id': 'https://openalex.org/I4210114217', 'display_name': 'National Institutes for Quantum and Radiological Science and Technology', 'ror': 'https://ror.org/020rbyg91', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114217']}, {'id': 'https://openalex.org/I1338135719', 'display_name': 'Centre for Addiction and Mental Health', 'ror': 'https://ror.org/03e71c577', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1338135719']}], 'countries': ['CA', 'JP'], 'is_corresponding': False, 'raw_author_name': 'Sho Moriguchi', 'raw_affiliation_strings': ['Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210114217']}, {'raw_affiliation_string': 'Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada', 'institution_ids': ['https://openalex.org/I1338135719']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102943186', 'display_name': 'Soichiro Kitamura', 'orcid': 'https://orcid.org/0000-0002-3190-8068'}, 'institutions': [{'id': 'https://openalex.org/I4210114217', 'display_name': 'National Institutes for Quantum and Radiological Science and Technology', 'ror': 'https://ror.org/020rbyg91', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114217']}, {'id': 'https://openalex.org/I64926303', 'display_name': 'Nara Medical University', 'ror': 'https://ror.org/045ysha14', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64926303']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Soichiro Kitamura', 'raw_affiliation_strings': ['Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'Department of Psychiatry, Nara Medical University, Nara, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210114217']}, {'raw_affiliation_string': 'Department of Psychiatry, Nara Medical University, Nara, Japan', 'institution_ids': ['https://openalex.org/I64926303']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065111183', 'display_name': 'Manabu Kubota', 'orcid': 'https://orcid.org/0000-0001-9507-1845'}, 'institutions': [{'id': 'https://openalex.org/I4210114217', 'display_name': 'National Institutes for Quantum and Radiological Science and Technology', 'ror': 'https://ror.org/020rbyg91', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114217']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Manabu Kubota', 'raw_affiliation_strings': ['Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210114217']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059623116', 'display_name': 'Satoshi Umeda', 'orcid': 'https://orcid.org/0000-0002-7808-0958'}, 'institutions': [{'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Satoshi Umeda', 'raw_affiliation_strings': ['Department of Psychology, Keio University, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychology, Keio University, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075040310', 'display_name': 'Fumitoshi Niwa', 'orcid': 'https://orcid.org/0000-0001-5431-5559'}, 'institutions': [{'id': 'https://openalex.org/I40677808', 'display_name': 'Kyoto Prefectural University of Medicine', 'ror': 'https://ror.org/028vxwa22', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I40677808']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fumitoshi Niwa', 'raw_affiliation_strings': ['Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I40677808']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083577097', 'display_name': 'Jin Mizushima', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Jin Mizushima', 'raw_affiliation_strings': ['Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111744188', 'display_name': 'Yoko Morimoto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoko Morimoto', 'raw_affiliation_strings': ['Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043144960', 'display_name': 'Michitaka Funayama', 'orcid': 'https://orcid.org/0000-0002-4473-9179'}, 'institutions': [{'id': 'https://openalex.org/I4210090177', 'display_name': 'Ashikaga Red Cross Hospital', 'ror': 'https://ror.org/0093xcb35', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799517759', 'https://openalex.org/I4210090177']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Michitaka Funayama', 'raw_affiliation_strings': ['Department of Psychiatry, Japanese Red Cross Ashikaga Hospital, Ashikaga, Tochigi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, Japanese Red Cross Ashikaga Hospital, Ashikaga, Tochigi, Japan', 'institution_ids': ['https://openalex.org/I4210090177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055238669', 'display_name': 'Hajime Tabuchi', 'orcid': 'https://orcid.org/0000-0002-2321-711X'}, 'institutions': [{'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hajime Tabuchi', 'raw_affiliation_strings': ['Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021503940', 'display_name': 'Kevin F. Bieniek', 'orcid': 'https://orcid.org/0000-0003-4922-864X'}, 'institutions': [{'id': 'https://openalex.org/I4210146710', 'display_name': 'Mayo Clinic in Florida', 'ror': 'https://ror.org/03zzw1w08', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210146710']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kevin F Bieniek', 'raw_affiliation_strings': ['Department of Neuroscience, Mayo Clinic, Jacksonville, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Mayo Clinic, Jacksonville, USA', 'institution_ids': ['https://openalex.org/I4210146710']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064403117', 'display_name': 'Kazunori Kawamura', 'orcid': 'https://orcid.org/0000-0001-6786-678X'}, 'institutions': [{'id': 'https://openalex.org/I64926303', 'display_name': 'Nara Medical University', 'ror': 'https://ror.org/045ysha14', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64926303']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazunori Kawamura', 'raw_affiliation_strings': ['Department of Psychiatry, Nara Medical University, Nara, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, Nara Medical University, Nara, Japan', 'institution_ids': ['https://openalex.org/I64926303']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111969936', 'display_name': 'Ming-Rong Zhang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114217', 'display_name': 'National Institutes for Quantum and Radiological Science and Technology', 'ror': 'https://ror.org/020rbyg91', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114217']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ming-Rong Zhang', 'raw_affiliation_strings': ['Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210114217']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009533777', 'display_name': 'Dennis W. Dickson', 'orcid': 'https://orcid.org/0000-0001-7189-7917'}, 'institutions': [{'id': 'https://openalex.org/I4210146710', 'display_name': 'Mayo Clinic in Florida', 'ror': 'https://ror.org/03zzw1w08', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210146710']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dennis W Dickson', 'raw_affiliation_strings': ['Department of Neuroscience, Mayo Clinic, Jacksonville, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, Mayo Clinic, Jacksonville, USA', 'institution_ids': ['https://openalex.org/I4210146710']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033519257', 'display_name': 'Masaru Mimura', 'orcid': 'https://orcid.org/0000-0002-3874-5273'}, 'institutions': [{'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masaru Mimura', 'raw_affiliation_strings': ['Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111973521', 'display_name': 'Motoichiro Kato', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Motoichiro Kato', 'raw_affiliation_strings': ['Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085556975', 'display_name': 'Tetsuya Suhara', 'orcid': 'https://orcid.org/0000-0003-2916-225X'}, 'institutions': [{'id': 'https://openalex.org/I4210114217', 'display_name': 'National Institutes for Quantum and Radiological Science and Technology', 'ror': 'https://ror.org/020rbyg91', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114217']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tetsuya Suhara', 'raw_affiliation_strings': ['Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210114217']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002819177', 'display_name': 'Makoto Higuchi', 'orcid': 'https://orcid.org/0000-0002-3934-5810'}, 'institutions': [{'id': 'https://openalex.org/I4210114217', 'display_name': 'National Institutes for Quantum and Radiological Science and Technology', 'ror': 'https://ror.org/020rbyg91', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114217']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Makoto Higuchi', 'raw_affiliation_strings': ['Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan', 'institution_ids': ['https://openalex.org/I4210114217']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 8, 'corresponding_author_ids': ['https://openalex.org/A5009790212'], 'corresponding_institution_ids': ['https://openalex.org/I4210114217', 'https://openalex.org/I203951103'], 'apc_list': {'value': 3658, 'currency': 'GBP', 'value_usd': 4486, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 8.413, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 63, 'citation_normalized_percentile': {'value': 0.849071, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '142', 'issue': '10', 'first_page': '3265', 'last_page': '3279'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10416', 'display_name': 'Traumatic Brain Injury Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10416', 'display_name': 'Traumatic Brain Injury Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10706', 'display_name': 'Traumatic Brain Injury and Neurovascular Disturbances', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10645', 'display_name': 'Cardiac Arrest and Resuscitation', 'score': 0.9889, 'subfield': {'id': 'https://openalex.org/subfields/2711', 'display_name': 'Emergency Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tau-pathology', 'display_name': 'Tau Pathology', 'score': 0.4499359}, {'id': 'https://openalex.org/keywords/chronic-traumatic-encephalopathy', 'display_name': 'Chronic traumatic encephalopathy', 'score': 0.4253376}], 'concepts': [{'id': 'https://openalex.org/C2781017439', 'wikidata': 'https://www.wikidata.org/wiki/Q1995526', 'display_name': 'Traumatic brain injury', 'level': 2, 'score': 0.6868076}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.57410586}, {'id': 'https://openalex.org/C3017833866', 'wikidata': 'https://www.wikidata.org/wiki/Q2397106', 'display_name': 'Tau pathology', 'level': 4, 'score': 0.4499359}, {'id': 'https://openalex.org/C2911139526', 'wikidata': 'https://www.wikidata.org/wiki/Q5114004', 'display_name': 'Chronic traumatic encephalopathy', 'level': 5, 'score': 0.4253376}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.41450024}, {'id': 'https://openalex.org/C61797465', 'wikidata': 'https://www.wikidata.org/wiki/Q1188986', 'display_name': 'Term (time)', 'level': 2, 'score': 0.41239518}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.36802655}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.35924757}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.35689396}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.2572691}, {'id': 'https://openalex.org/C3017944768', 'wikidata': 'https://www.wikidata.org/wiki/Q1450463', 'display_name': 'Poison control', 'level': 2, 'score': 0.21985495}, {'id': 'https://openalex.org/C190385971', 'wikidata': 'https://www.wikidata.org/wiki/Q373494', 'display_name': 'Injury prevention', 'level': 3, 'score': 0.20096102}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.16499242}, {'id': 'https://openalex.org/C2778426673', 'wikidata': 'https://www.wikidata.org/wiki/Q326921', 'display_name': 'Concussion', 'level': 4, 'score': 0.12228009}, {'id': 'https://openalex.org/C194828623', 'wikidata': 'https://www.wikidata.org/wiki/Q2861470', 'display_name': 'Emergency medicine', 'level': 1, 'score': 0.088107765}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000070642', 'descriptor_name': 'Brain Injuries, Traumatic', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': True}, {'descriptor_ui': 'D000070642', 'descriptor_name': 'Brain Injuries, Traumatic', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D024801', 'descriptor_name': 'Tauopathies', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000070642', 'descriptor_name': 'Brain Injuries, Traumatic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000070627', 'descriptor_name': 'Chronic Traumatic Encephalopathy', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000070627', 'descriptor_name': 'Chronic Traumatic Encephalopathy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001523', 'descriptor_name': 'Mental Disorders', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001523', 'descriptor_name': 'Mental Disorders', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D001523', 'descriptor_name': 'Mental Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049268', 'descriptor_name': 'Positron-Emission Tomography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049268', 'descriptor_name': 'Positron-Emission Tomography', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D011618', 'descriptor_name': 'Psychotic Disorders', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D011618', 'descriptor_name': 'Psychotic Disorders', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011618', 'descriptor_name': 'Psychotic Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024801', 'descriptor_name': 'Tauopathies', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D024801', 'descriptor_name': 'Tauopathies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066127', 'descriptor_name': 'White Matter', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D066127', 'descriptor_name': 'White Matter', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016875', 'descriptor_name': 'tau Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/brain/awz238', 'pdf_url': 'https://academic.oup.com/brain/article-pdf/142/10/3265/30063875/awz238.pdf', 'source': {'id': 'https://openalex.org/S118357697', 'display_name': 'Brain', 'issn_l': '0006-8950', 'issn': ['0006-8950', '1460-2156'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31504227', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/brain/awz238', 'pdf_url': 'https://academic.oup.com/brain/article-pdf/142/10/3265/30063875/awz238.pdf', 'source': {'id': 'https://openalex.org/S118357697', 'display_name': 'Brain', 'issn_l': '0006-8950', 'issn': ['0006-8950', '1460-2156'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.71}], 'grants': [{'funder': 'https://openalex.org/F4320311405', 'funder_display_name': 'Japan Agency for Medical Research and Development', 'award_id': None}, {'funder': 'https://openalex.org/F4320334764', 'funder_display_name': 'Japan Society for the Promotion of Science', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 70, 'referenced_works': ['https://openalex.org/W126426573', 'https://openalex.org/W1565425914', 'https://openalex.org/W1992298761', 'https://openalex.org/W1996332875', 'https://openalex.org/W1999173521', 'https://openalex.org/W2004717303', 'https://openalex.org/W2009870816', 'https://openalex.org/W2015860144', 'https://openalex.org/W2019793985', 'https://openalex.org/W2031306362', 'https://openalex.org/W2041802741', 'https://openalex.org/W2048137511', 'https://openalex.org/W2052459267', 'https://openalex.org/W2070632079', 'https://openalex.org/W2072805367', 'https://openalex.org/W2073009405', 'https://openalex.org/W2075580913', 'https://openalex.org/W2077024919', 'https://openalex.org/W2081325915', 'https://openalex.org/W2084627664', 'https://openalex.org/W2098216041', 'https://openalex.org/W2100285775', 'https://openalex.org/W2106837589', 'https://openalex.org/W2107537187', 'https://openalex.org/W2124200927', 'https://openalex.org/W2134116989', 'https://openalex.org/W2135488666', 'https://openalex.org/W2138666077', 'https://openalex.org/W2141679195', 'https://openalex.org/W2143090160', 'https://openalex.org/W2143523287', 'https://openalex.org/W2156511539', 'https://openalex.org/W2161569931', 'https://openalex.org/W2162343085', 'https://openalex.org/W2170921124', 'https://openalex.org/W2217184110', 'https://openalex.org/W2226677960', 'https://openalex.org/W2230586536', 'https://openalex.org/W2253155352', 'https://openalex.org/W2253582495', 'https://openalex.org/W2294884050', 'https://openalex.org/W2336107543', 'https://openalex.org/W2346180510', 'https://openalex.org/W2460293179', 'https://openalex.org/W2492785636', 'https://openalex.org/W2521964640', 'https://openalex.org/W2523775282', 'https://openalex.org/W2528917098', 'https://openalex.org/W2561318455', 'https://openalex.org/W2569343483', 'https://openalex.org/W2579510648', 'https://openalex.org/W2602908130', 'https://openalex.org/W2609596481', 'https://openalex.org/W2621216028', 'https://openalex.org/W2750121529', 'https://openalex.org/W2766901297', 'https://openalex.org/W2771176174', 'https://openalex.org/W2771934679', 'https://openalex.org/W2785763878', 'https://openalex.org/W2854246310', 'https://openalex.org/W2904378747', 'https://openalex.org/W2923068715', 'https://openalex.org/W2936881644', 'https://openalex.org/W3025340659', 'https://openalex.org/W4239225232', 'https://openalex.org/W4241684762', 'https://openalex.org/W4244977113', 'https://openalex.org/W4253308936', 'https://openalex.org/W4294747801', 'https://openalex.org/W60931028'], 'related_works': ['https://openalex.org/W4396213806', 'https://openalex.org/W4224279150', 'https://openalex.org/W3140145712', 'https://openalex.org/W2971397699', 'https://openalex.org/W2963219749', 'https://openalex.org/W2886141281', 'https://openalex.org/W2522097803', 'https://openalex.org/W2520999970', 'https://openalex.org/W2405250948', 'https://openalex.org/W2202598794'], 'abstract_inverted_index': {'Is': [0], 'tau': [1, 14, 26, 38], 'load': [2, 27], 'associated': [3, 43], 'with': [4, 18, 44], 'long-term': [5], 'outcomes': [6], 'of': [7, 37], 'TBI?': [8], 'By': [9], 'using': [10], 'PET': [11], 'to': [12, 29], 'assess': [13], 'deposits': [15], 'in': [16, 39], 'patients': [17], 'chronic': [19], 'TBI,': [20], 'Takahata': [21], 'et': [22], 'al.': [23], 'reveal': [24], 'elevated': [25], 'compared': [28], 'age-matched': [30], 'controls,': [31], 'and': [32], 'show': [33], 'that': [34], 'the': [35], 'abundance': [36], 'white': [40], 'matter': [41], 'is': [42], 'late-onset': [45], 'neuropsychiatric': [46], 'symptoms.': [47]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2972919080', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 20}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 12}], 'updated_date': '2025-01-06T21:30:38.508531', 'created_date': '2019-09-19'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
