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2488, 2521, 2545, 2558, 2562, 2576, 2594, 2599, 2619, 2638, 2656, 2716, 2733, 2793, 2803, 2812, 2817, 2886, 2902, 2943, 2950, 2976, 2998, 3087, 3117, 3218, 3290, 3314, 3356, 3477, 3521, 3549, 3629, 3657, 3789, 3846, 3965, 4006, 4110, 4135, 4223, 4243, 4390, 4409, 4713, 4771, 4778, 4804], 'backgroundSeveral': [67], 'transporters': [69, 124, 240, 250, 274, 524, 673, 718, 988, 1134, 1185, 1319, 2012, 2119, 2173, 2184, 2261, 2314, 2331, 2416, 2457, 2472, 2585, 2661, 2677, 2743, 2806, 2854, 2896, 2987, 3052, 3121, 3152, 3485, 3757, 3813, 3849, 3912, 4250, 4577], '(e.g.,': [70, 516, 820, 1637, 1885, 2013, 2482, 2520, 2861], 'ABCB1,': [71, 213, 1407, 2185, 2229, 2245, 2610, 3753, 4632], 'ABCB4,': [72], 'ABCC1–5,': [73], 'ABCC10,': [74], 'ABCG2': [75, 162, 216, 495, 1218, 2232, 2248, 2613, 3662, 3990, 4196, 4493, 4628, 4635], 'ABCG4)': [77], 'are': [78, 232, 251, 445, 679, 887, 994, 1011, 1024, 1076, 1177, 1573, 1609, 1651, 2615, 2754, 2883, 3913], 'known': [79, 374, 2718], 'contribute': [81, 1352], 'phenomenon': [84], 'cancer-related': [86, 555, 720, 801, 1110, 1145, 2461, 2607, 2775], 'multidrug': [87, 3022, 3216, 3295, 3321, 3411, 3554, 3697, 3723, 3760, 4036], 'resistance': [88, 571, 734, 771, 1282, 1640, 1779, 2364, 2423, 3023, 3091, 3322, 3561, 3593, 3761, 3877, 4198, 4342], '(MDR)': [89], '[1].': [90, 122], 'Expression': [91, 4515], 'occurs': [92], 'either': [93, 237, 1591, 2005], 'inherently': [94], '(chemo-naive': [95], 'patient)': [96, 105], 'or': [97, 205, 386, 409, 442, 587, 760, 1003, 1129, 1238, 1265, 1402, 1450, 1557, 1596, 1642, 1807, 2007, 2102, 2146, 2199, 2215, 2377, 2420, 2427, 2777, 2780, 2879, 2926, 2932, 2939, 2946, 2959, 2964, 2967, 2969, 4754, 4760, 4767, 4774, 4787, 4792, 4795, 4797], 'is': [98, 217, 263, 530, 547, 557, 794, 950, 1147, 1345, 1360, 1371, 1647, 1744, 1878, 1917, 1944, 2206, 2436, 2637, 2701, 2997, 3153, 3962, 3991], 'acquired': [99], 'after': [100], 'initial': [101, 1880], 'cancer': [102, 108, 288, 773, 945, 2108, 2341, 2878, 3323, 3560, 3592, 3700, 3763, 4189, 4341, 4353, 4356, 4441], 'chemotherapy': [103, 3703], '(chemo-treated': [104], 'in': [106, 173, 254, 275, 287, 295, 337, 629, 664, 677, 719, 726, 892, 915, 921, 939, 989, 1000, 1007, 1021, 1039, 1067, 1085, 1112, 1142, 1233, 1249, 1320, 1581, 1586, 1627, 1894, 1905, 1911, 1920, 1926, 1949, 1962, 1980, 2035, 2084, 2091, 2099, 2107, 2134, 2196, 2285, 2308, 2339, 2367, 2536, 2573, 2590, 2604, 2651, 2679, 2697, 2744, 2765, 2770, 2862, 2873, 2897, 2909, 2915, 2938, 2949, 2975, 2988, 3024, 3053, 3077, 3122, 3158, 3253, 3320, 3347, 3762, 3821, 3853, 3916, 3970, 3993, 4187, 4202, 4218, 4234, 4242, 4251, 4288, 4360, 4396, 4399, 4405, 4419, 4440, 4578, 4672, 4732, 4766, 4777, 4803], 'certain': [107, 255, 283, 1234, 1270, 1311, 1385, 1502, 1635, 2405, 2670], 'types': [109], '(such': [110, 572, 849, 1433, 1455, 1801, 2064, 2773], 'as': [111, 219, 258, 554, 573, 754, 850, 867, 877, 1115, 1162, 1274, 1420, 1434, 1456, 1554, 1570, 1716, 1757, 1802, 2065, 2174, 2243, 2281, 2480, 2774, 2828, 2858, 3225, 3342, 3473, 3515, 3545, 3586, 3720, 3750, 4003, 4032, 4054, 4087, 4116, 4335, 4377, 4511, 4626, 4655], 'bladder,': [112], 'blood,': [113], 'brain,': [114], 'breast,': [115], 'colon,': [116], 'kidney,': [117], 'lung,': [118], 'ovary': [119], 'pancreas)': [121], 'recognize': [125], 'a': [126, 220, 265, 278, 302, 334, 548, 558, 641, 731, 748, 788, 933, 1008, 1022, 1139, 1336, 1361, 1372, 1417, 1466, 1501, 1545, 1694, 1717, 1955, 1972, 2038, 2282, 2305, 2353, 2537, 2565, 2570, 2587, 2680, 2693, 2724, 2874, 2935, 3351, 3418, 3487, 4084, 4271, 4297, 4557, 4763], 'broad': [127, 2698], 'range': [128, 151, 168, 2204, 2700], 'structurally': [130], 'unrelated': [131], 'antineoplastic': [132, 171, 758, 1070, 1195, 1288, 1984, 1995, 2359], 'agents': [133, 172, 508, 1196], 'inside': [134], '(cancer)': [135, 991, 1005, 1751, 1783, 1868, 1963, 1988], 'cells': [136, 685, 774, 1006, 1020, 1784, 1964, 1989, 3618, 3701], 'translocate': [138], 'these': [139, 239, 248, 347, 828, 1090, 1175, 1221, 1649, 2041, 2348, 2439, 2644, 2797], 'into': [140, 471, 1123, 1479, 2478, 2557], 'exterior': [142], 'using': [143, 696, 813, 1193, 3486], 'energy': [145], 'ATP': [147, 3149], 'hydrolysis.': [148], 'The': [149, 242, 579, 1735, 1847, 2129, 2629, 3047], 'substrate': [150, 2351, 2357, 2401], 'most': [154, 243, 447, 1325, 1482, 2630], 'studied': [155], 'representatives': [156, 284, 449, 1386, 1834, 2268, 2603, 2719], 'ABCB1': [157, 421, 484, 663, 810, 1206, 2122, 3292, 3524, 3660, 3694, 3850, 4180, 4194], '(P-gp),': [158], 'ABCC1': [159, 214, 461, 490, 1210, 1408, 1477, 1925, 2186, 2230, 2246, 2333, 2464, 2611, 3250, 3294, 3481, 3852, 3969], '(MRP1)': [160, 3482], '(BCRP)': [163], 'covers': [164], 'almost': [165, 1081], 'whole': [167], '(small-molecule)': [170], 'use': [174, 1347, 1424, 1592], 'today,': [175], 'example,': [177, 384, 982, 1445], 'anthracyclines': [178], '(B1,': [179, 182, 186, 190, 208], 'C1),': [180], 'antifolates': [181], 'C1,': [183, 187, 191, 203], 'G2),': [184, 188, 192], 'camptothecins': [185], 'epipodophyllotoxins': [189], 'nitrogen': [193], 'mustards': [194], '(C1),': [195], 'taxanes': [196], '(B1),': [197], 'tyrosine': [198, 3222], 'kinase': [199, 3223, 3311], 'inhibitors': [200, 366, 370, 422, 702, 860, 1066, 1179, 1399, 1478, 1495, 1712, 2249, 2301, 2501, 2832, 3224, 3312, 3409, 3519, 3547, 3589, 4201], '(TKIs': [201], '[B1,': [202], 'G2])': [204], 'vinca': [206], 'alkaloids': [207], 'C1)': [209], '[1–3].': [210], 'Occurrence': [211], 'and/or': [215, 2017, 2068], 'recognized': [218, 951, 2293], 'negative': [221], 'marker': [222], 'outcome': [225, 2992], 'chemotherapeutic': [227, 591, 3318, 3621], 'intervention,': [228], 'relapsed/refractory': [230, 944], 'malignancies': [231], 'associated': [233, 2459, 2622, 3154, 3626], 'with': [234, 311, 757, 816, 845, 1069, 1089, 1197, 1287, 1315, 1389, 1684, 1982, 1993, 2037, 2071, 2098, 2104, 2233, 2460, 2502, 2542, 2623, 2767, 2800, 2929, 2934, 2942, 3155, 3258, 3345, 3349, 3627, 3996, 4185, 4380, 4757, 4762, 4770], 'overexpression': [235], '[4].': [241, 786], 'recent': [244, 3422], 'analyses': [245], 'confirmed': [246], 'that': [247, 450, 952, 1055, 1174, 1304, 1526, 1589, 1648, 1721, 1774, 1954, 2326, 2375, 2404, 2445, 2583, 2720], 'three': [249, 1182, 2181, 2260, 2328, 2454, 2602], 'also': [252, 459, 1178, 1560, 1910, 1968, 2373, 2474], 'co-expressed': [253, 2338], 'cancers,': [256], 'such': [257, 876, 1114, 1505, 1553, 1569], 'leukemia': [259], '[5].': [260], 'However,': [261, 464, 1220, 1341, 1670, 2655], 'there': [262, 1227, 1370], 'still': [264, 509, 888, 961, 2155], 'lack': [266, 658], 'understanding': [268], 'regarding': [269, 344, 460, 1396], 'interplay': [271], 'between': [272, 280, 1851, 1863], 'general,': [276, 1113, 2898], 'correlation': [279], 'co-expression': [281, 2354], 'prognosis': [286, 3157], 'has': [289, 646, 1228, 1394, 1500, 1511, 1825, 2240, 2279, 2290, 3186, 4556], 'only': [290, 372, 465, 910, 1230, 1332, 1577, 2237, 2265, 2496, 2508, 2620, 2665, 2760], 'very': [291, 360, 1632, 1832, 2600], 'recently': [292, 1483, 2324], 'been': [293, 373, 648, 1191, 1229, 1298, 1828, 2125, 2226, 2241, 2292], 'addressed': [294, 649], 'literature': [297, 1922], '[6].Inhibitors': [298], 'historic': [303, 3419], 'approachEver': [304], 'since': [305, 355, 1324], 'their': [306, 325, 675, 907, 2255, 2356, 2398, 2422, 2673, 2763, 2783, 4584], 'discovery,': [307], 'two': [308, 1294], 'questions': [309], 'arose': [310], 'regard': [312], '(i)': [316, 584, 730, 1226, 1300, 1430, 1590, 1877, 2025, 2058, 2321, 2820], 'how': [317, 323], 'do': [318, 974, 1900], 'they': [319, 868], 'work?;': [320], '(ii)': [322, 593, 740, 1248, 1323, 1438, 1597, 1899, 2027, 2088, 2370, 2847], 'can': [324, 653, 686, 909, 1307, 1541, 1658, 1754, 1767, 1840, 2394, 2807], 'activity': [326, 340, 3181, 3252], 'be': [327, 564, 654, 689, 737, 745, 752, 912, 927, 1256, 1308, 1660, 1755, 1768, 1841, 1969, 2020, 2162, 2169, 2337, 2384, 2395, 2476, 2729, 2808, 2871], 'manipulated?': [328], 'Small-molecule': [329, 3408], 'modulators': [332, 2671, 2753, 2799, 2851, 2908, 3721, 3751], 'play(ed)': [333], 'huge': [335, 412, 1392, 1667, 2546, 2784], 'role': [336, 2589, 2764, 3049, 3118, 3220, 4244], 'changing': [338], 'transport': [339, 2627, 3251, 3479, 3522, 3551, 3967], 'draw': [342], 'conclusions': [343], 'function': [345, 676, 3630], 'efflux': [348, 620, 2645, 3938], 'pumps.': [349], 'Nearly': [350], '30': [351, 2253], 'years': [352, 2299], 'have': [353, 371, 766, 1190, 1297, 1327, 2123, 2225, 2349, 2407, 2473, 2922, 4750], 'passed': [354], 'discovery': [357, 1486, 2639], 'first': [361, 807, 1848], 'high-throughput': [362], 'screening-': [363], 'synthesis-derived': [365], 'ABCB1.': [368], 'Before,': [369], 'from': [375, 1770, 1814, 2715, 2749, 3086, 4175], 'other': [376, 1048, 1292, 1538, 2120, 2172, 2470], 'pharmacological': [377, 393, 814, 818, 4268], 'fields': [378], '(so-called': [379], '‘first': [380], 'generation’': [381], 'inhibitors;': [382], 'verapamil': [385], 'cyclosporine': [387], 'A)': [388], '[2,3],': [389], 'exerting': [390], 'additional': [391], '(negative)': [392], 'effects.': [394], 'Pharmaceutical': [395], 'companies': [396], 'like': [397, 2052], 'CBA': [398], 'Pharma,': [399], 'Eli': [400], 'Lilly,': [401], 'Immunex,': [402], 'Janssen,': [403], 'GlaxoSmithKline,': [404], 'Mitsui,': [405], 'Pfizer,': [406], 'Sandoz,': [407], 'Vertex': [408], 'Xenova': [410], 'spent': [411], 'effort': [413], 'generate': [415, 1794], 'novel,': [416], 'highly': [417, 1029, 2849, 3587], 'potent': [418, 872, 1709, 1852, 1861, 1956, 2708, 2711, 3588], 'nontoxic': [420, 1974], '[2,3].': [423, 822], 'CP100356,': [424], 'CBT-1,': [425, 475], 'GF120918': [426, 493], '(elacridar),': [427], 'LY335979': [428], '(zosuquidar),': [429], 'MS-209': [430, 486], '(dofequidar),': [431], 'PSC': [432, 478], '833': [433], '(valspodar),': [434], 'R101933': [435], '(laniquidar),': [436], 'S': [437, 4683], '9788,': [438], 'VX-710': [439, 480, 488], '(biricodar),': [440], 'XR9051': [441], 'XR9576': [443, 482], '(tariquidar)': [444], 'famous': [448], 'marked': [451], 'fundament': [453], 'modern': [455, 669, 789, 2631], 'inhibitors,': [458, 1018], 'ABCG2.': [463, 1410, 2188, 3526, 3632], 'few': [466, 1833, 2666, 2717], 'compounds': [467, 1176, 1614, 1800, 2003, 2051, 2166, 2224, 2510, 2667, 2727, 2827], 'found': [468, 2901], 'way': [470, 2999], 'clinical': [472, 514, 533, 803, 893, 947, 957, 970, 1044, 1096, 1149, 1188, 1382, 2105, 2117, 2567, 2839, 2991, 3054, 3191], 'oncology': [473], '(including': [474], 'LY335979,': [476], 'MS-209,': [477], '833,': [479], 'against': [483, 489, 494, 809, 936, 1205, 1209, 1217, 1313, 1785, 1867, 1924, 1933, 2171, 2179, 2228, 2258, 2365, 2841, 2877, 4560], '[3,7];': [485], '[7];': [491], '[8]).': [496], 'Most': [497], 'trials': [498, 623, 902, 1097, 1222, 1235], 'were': [499, 633, 811, 832, 861, 869, 959, 1061, 1160, 1272, 1631, 1681, 2511], 'terminated': [500], 'due': [501, 1258, 2317, 2761, 2781], 'severe': [503, 846, 1260], 'side': [504, 1261], 'effects,': [505], 'leaving': [506], 'sparse': [507], 'under': [510, 3704], 'consideration': [511, 2044], 'ongoing': [513, 1663, 2468], 'evaluation': [515, 1383, 1568, 1664, 1884, 2891], 'CBT-1)': [517], '[3,4].': [518, 903, 1032], 'No': [519], 'authority-approved': [520], 'inhibitor': [521, 1742, 1788, 2137, 2444, 3475, 4338], 'exists': [525], 'until': [526, 2549], 'today.': [527], 'Hence,': [528, 787, 924, 1105, 1497, 1563], 'problem?The': [532], 'problem:': [534, 804, 948, 1150, 1367, 1617, 2111], 'study': [535, 728, 792], 'designClinical': [536], 'studies': [537, 808, 2106, 2118], 'conducted': [538, 1192, 1682], 'did': [539, 1245], 'absolutely': [540], 'not': [541, 647, 975, 1026, 1246, 1515, 1576, 1827, 2124, 2759], 'meet': [542], 'expected': [544], 'results.': [545], 'This': [546, 652, 1033, 1411, 1703, 1765, 1915, 2451, 2810, 2952, 4780], 'multi-faceted': [549], 'problem': [550, 1362], 'on': [551, 1101, 1416, 1429, 1476, 1504, 2097, 2544, 2675, 2786, 3361, 4134, 4389, 4709], 'different': [552, 996, 1117, 1421, 1425, 1472, 1587, 1593, 1600], 'levels': [553, 985], 'MDR': [556, 645, 1111, 1146, 1305, 1628, 1678, 1762, 1895, 1912, 1932, 1947, 1961, 2033, 2082, 2462, 2519, 2608, 2776, 3076], 'complex': [559], 'issue': [560, 891], 'which': [561, 630, 842, 895, 1548, 1743, 2159, 2289, 2362, 2393, 2560, 2835, 2855, 2899], 'mostly': [562, 1826, 2458], 'cannot': [563], 'attributed': [565, 655, 2396], 'one': [567, 889, 953, 1333, 1342, 1582, 2141, 2238, 2340, 2381], 'single': [568, 1583], 'mechanism': [569, 735, 1284], 'expression': [575, 984, 1130, 1316], 'transporters).': [578], 'involved': [580], 'modes': [581], 'comprise': [582], 'of:': [583], 'decreased': [585], 'influx': [586], 'reduced': [588], 'uptake': [589], 'agents;': [592], 'alteration': [594], 'cell': [597, 992, 2342, 3886, 4204, 4357, 4456], 'cycle': [598], 'leading': [599], 'changed': [601], 'drug': [602, 1121, 3090, 3179, 4453, 4484, 4588], 'target(s);': [603], '(iii)': [604, 1269, 1451, 2031], 'increased': [605], 'DNA': [606], 'repair;': [607], '(iv)': [608], 'altered': [609], 'metabolism': [610], 'applied': [613, 1285], 'drug(s);': [614], '(v)': [616], 'increase': [617], 'energy-dependent': [619], '[2].': [621], 'In': [622, 682, 1605, 2467], "1990's": [626], '2000’s,': [628], 'patient': [631, 742, 784], 'populations': [632, 743, 785], 'chosen': [634], 'tumor': [636, 1001, 1023, 1056], 'type,': [637], 'presence': [639, 2413], 'transporter-dominated': [642, 733], 'mode': [643, 2682, 2734], 'properly': [650, 2127], '[3].': [651, 2128], 'methods': [660, 711, 725], 'assess': [662], 'respective': [666], 'tumor(s).': [667], 'Nowadays,': [668], 'biomarkers': [670], 'image': [672], 'vivo': [678, 922, 2100], 'available': [680, 1379], '[5,9].': [681], 'addition,': [683, 1606], 'biopsy-derived': [684], 'easily': [688], 'screened': [690, 2170], 'applying': [691, 2083], 'novel': [692, 1357, 1506, 1534, 2825, 4033, 4373, 4492], 'fluorescence-based': [693], 'accumulation': [694, 3284], 'assays': [695, 919, 1426, 1588, 1630, 1680, 1908], 'specific': [697, 1550, 2142, 2850, 3445], '(or': [698, 2833, 2843], 'broad-spectrum)': [699], '[10].': [703], 'Western-blotting': [704], 'PCR': [706], 'complement': [707], 'fund': [709], 'determine': [713, 2209], 'participation': [715], 'MDR.': [721, 1702], 'Including': [722], 'mentioned': [724, 2023], 'future': [727, 942, 2889, 2905, 2912, 4587], 'designs,': [729], 'putative': [732], 'could': [736, 744, 765, 2551, 2728, 2856, 2870], 'determined,': [738], 'proper': [741], 'selected.': [746], 'Furthermore,': [747, 1072], 'clever': [749], 'randomization': [750], 'should': [751, 1967, 2019], 'performed,': [753], 'run-in': [755], 'phases': [756], 'agents,': [759], '(usually': [761], 'chosen)': [762], 'cross-over': [763, 1603], 'designs': [764], 'disadvantage': [768, 1646], 'promoting': [770], 'therefore': [776, 2418], 'de': [777], 'facto': [778], 'change': [779, 2419], 'preconditions': [781], 'innovative': [791], 'design': [793, 4485], 'needed': [795, 1610, 1745, 2212, 2815], 'address': [797], 'all': [798, 1082, 2165, 2259, 2447], 'peculiarities': [799], 'MDR.The': [802], 'compound-related': [805, 1551], 'aspectsThe': [806], 'performed': [812], 'drugs': [815, 875, 1094], 'inherent': [817], 'profile': [819, 2424, 2490], 'verapamil)': [821], 'Due': [823], 'low': [825, 2200, 2685], 'potency': [826], 'drugs,': [829], 'high': [830, 2197, 2756, 2768], 'doses': [831], 'necessary': [833, 2813], 'obtain': [835, 2074], 'desired': [837], 'effect': [838], '(ABC': [839], 'inhibition),': [841], 'went': [843], 'along': [844], 'adverse': [847, 881], 'events': [848, 882, 905], 'heart': [851], 'block': [852], '[verapamil]).': [853], 'Second-': [854], 'third-generation': [856], 'small-molecule': [857, 1167], 'used': [862, 990, 1309, 1661, 1787, 1842, 2872], 'at': [863, 1574, 1598, 2147, 2177, 2593, 2684, 2689, 2885, 4005], 'much': [864, 995, 1704], 'lower': [865], 'dose,': [866], 'significantly': [870], 'than': [873, 999, 1331, 2121, 2252], 'first-generation': [874], 'verapamil.': [878], 'Nevertheless,': [879, 1087, 1465, 2274], 'unforeseen': [880], 'potentially': [884], 'life-threatening': [885], 'severity': [886, 908], 'major': [890, 954, 1183, 1295, 1343, 2182, 2329, 2455], 'evaluations,': [894], 'already': [896], 'led': [897, 1481], 'termination': [899], 'many': [901, 1050, 1243, 1799], 'Adverse': [904], 'marginally': [911], 'anticipated': [913], 'vitro': [916, 1040], 'cytotoxicity/cell': [917], 'viability': [918], 'experiments.': [923], 'it': [925, 1035, 1171, 1966, 2322, 2371, 2580, 3187], 'must': [926, 2167], 'pondered:': [928], 'potential': [930, 967, 3084, 4269], 'risk': [931], 'new': [934, 1607, 1619, 1718, 2061, 2075, 2283, 2306, 2538, 2554, 2571, 2641, 3281, 4333], 'therapy': [935, 1141, 2876], 'death': [938], 'immediate': [941], 'patients.The': [946, 2109], 'preclinicsIt': [949], 'impediment': [955], 'success': [958], '(and': [960, 2154], 'are)': [962], 'preclinical': [963, 1083], 'models': [964, 973, 1053, 1084], 'cast': [966], 'candidates': [968, 2556], 'evaluation.': [971], 'These': [972, 2022], 'mirror': [976], 'physiological': [978], 'reality': [979], '–': [980, 1400, 1404, 1427, 2145, 2150, 2176, 2193, 2205, 2609, 2614, 2713, 2723], 'lines': [993], '(i.e.': [997], 'higher)': [998], 'cells;': [1002], 'one-layer': [1004], 'culture': [1009], 'flask': [1010], 'completely': [1012], 'accessible': [1013], 'adjuvant': [1015, 1198], 'while': [1019, 1242, 2139], 'often': [1025, 2157, 2678], '(except': [1027], 'vascularized': [1030], 'tissue)': [1031], 'makes': [1034, 1549], 'difficult': [1036], 'translate': [1038, 1688], 'results': [1041, 1775], 'positive': [1043], 'outcomes.': [1045], 'On': [1046, 1290, 1536], 'hand,': [1049, 1293, 1539], 'mice': [1051, 3257], 'xenograft': [1052], 'showed': [1054], 'growth': [1057], 'inhibition': [1058, 1907, 2278, 2379, 2688, 3880, 4181], 'shrinkage': [1060], 'achievable': [1062], 'combination': [1068, 1981, 2036], 'agents.': [1071, 1169, 1289, 1358, 1535, 3227], 'artificial': [1073, 1091], 'test': [1074, 1092], 'setups': [1075, 1093], 'common': [1077, 1194], 'apply': [1079], 'pharmacology.': [1086], 'even': [1088, 2103, 2194, 2823], 'enter': [1095, 2838], 'get': [1099], 'approval': [1100], 'world': [1102], 'health': [1103], 'markets.': [1104], 'considering': [1106], 'characteristics': [1108], 'mode(s)': [1118], 'resistance,': [1120], 'penetration': [1122], 'tumor(s),': [1125], 'polymorphism': [1128], 'multiple': [1132], '[3–6],': [1135], 'development': [1137, 1355], 'targeted': [1140, 2875], 'transporter-driven': [1144, 2310], 'feasible.The': [1148], 'state': [1151], 'artWithin': [1154], 'last': [1156, 1673, 1726, 2577], '20': [1157, 1674, 2578], 'years,': [1158, 1675, 2579], 'TKIs': [1159, 1271, 1326, 1804, 2522], 'developed': [1161], 'newest': [1164], 'class': [1165], 'anticancer': [1168, 4381], 'Soon,': [1170], 'was': [1172, 1302, 1722, 2153, 2323, 2372, 2581, 2662, 2973, 3625, 4801], 'discovered': [1173, 2582], '[8,11].': [1186, 1219], 'Several': [1187], 'evaluations': [1189, 2101, 2840], 'TKIs,': [1199], 'including': [1200], 'lapatinib,': [1201], 'nilotinib': [1202, 1208], 'sunitinib': [1204, 1216, 1806, 2524, 3624], '[8,11,12];': [1207], '[12];': [1211], 'gefitinib,': [1213], 'lapatinib': [1214], 'encountered': [1223], 'well-known': [1224], 'impediments:': [1225], 'partial': [1231], 'benefit': [1232, 2316], '(complete': [1236], 'remission': [1237], 'enhanced': [1239, 3313], 'progression-free': [1240], 'period),': [1241], 'patients': [1244, 3348], 'respond;': [1247], 'some': [1250], 'cases': [1251], 'trial': [1253, 3354], 'had': [1254, 2269], 'aborted': [1257], 'effects': [1262, 2440, 2674], '(cytotoxic': [1263], 'agent-': [1264], 'TKI-related': [1266], 'effects);': [1267], 'identified': [1273], 'substrates': [1275], 'transporters,': [1278], 'hence': [1279], 'same': [1281, 1677, 2130, 2601], '(promoting)': [1283], 'compared': [1286, 1992], 'achievements': [1296], 'made:': [1299], 'proof': [1301, 1525, 1953], 'given': [1303], 'reversers': [1306], '(under': [1310], 'circumstances)': [1312], 'cancers': [1314, 2406], 'general;': [1321, 2368], 'affinity': [1328], 'transporter,': [1335, 2143], 'multi-target': [1337, 2275, 2492, 2829], 'approach': [1338, 1470, 2284, 2307, 2541, 3420], 'became': [1339, 1713], 'promising.': [1340], 'obstacle': [1344], 'existing': [1349], 'data': [1350, 1368, 1378, 1475, 1498, 1540, 1792, 1818], 'It': [1359], 'compound': [1364, 1567, 1695, 1862, 1883, 1957, 1979, 2695, 2890], 'quantification.The': [1365], 'quantification': [1366, 1529, 1616, 2110], 'deviationToday': [1369], 'unique': [1373], 'chance': [1374, 2563], 're-evaluate': [1376], 're-consider': [1381], '[13–15].': [1387], 'Compared': [1388], '1990’s,': [1391], 'information': [1393, 1412, 2814], 'accumulated': [1395, 2548], 'selective': [1401, 2214, 2378, 3516, 3793, 4336], 'nonselective': [1403], 'especially': [1405], 'concerning': [1406, 2894], 'deviates': [1413], 'course': [1415], 'natural': [1418], 'basis,': [1419], 'work': [1422], 'groups': [1423], 'dependency': [1428], 'detection': [1431, 1594], 'method': [1432, 1523], 'radioactivity': [1435], 'vs': [1436, 1461], 'fluorescence);': [1437], 'tracer': [1439], '(substrate': [1440], 'transporters;': [1443], 'doxorubicin': [1446, 3346, 4186], 'vs.': [1447], 'calcein': [1448], 'AM);': [1449], 'transporter-carrying': [1453], 'host': [1454], 'reconstituted/enriched': [1457], 'inside–out': [1458], 'membrane': [1459, 3966], 'vesicles': [1460], 'selected/transfected': [1462], 'living': [1463], 'cells).': [1464], 'computational': [1467, 2062, 2540, 2704, 2791], 'virtual': [1468, 3489], 'screening': [1469, 2149, 3490], 'taking': [1471], '(naturally': [1473], 'deviating)': [1474], 'account': [1480, 2479], 'several': [1488, 2313, 2319, 2553, 3388], 'specific,': [1489], 'dual': [1490, 3219, 3518], 'broad-spectrum': [1492, 2216, 2798, 3546], '[16].': [1496, 2250], 'deviation': [1499], 'impact': [1503, 1510, 2785], 'methods,': [1507, 1595], 'but': [1508, 1585, 1810], 'limits': [1512, 4538], 'does': [1514], 'necessarily': [1516], 'compromise': [1517], 'experimental': [1519], 'outcome.': [1520], 'Instead,': [1521, 2164], 'gave': [1524], 'right': [1528, 2114], 'measure': [1530, 1719, 1766, 1796, 1823, 1890, 1943], 'will': [1531, 2055, 2836, 2900], 'lead': [1532], 'variate,': [1542], 'sometimes': [1543], 'over': [1544], 'wide': [1546], 'range,': [1547, 2361], 'measures,': [1552], 'inhibitory': [1555, 2256], 'power': [1556, 2257], 'activating': [1558], 'nature,': [1559], 'assay': [1561, 1928, 3285], 'specific.': [1562], 'characteristic': [1564], 'measures': [1565, 1608, 1636, 2532], 'IC50': [1572, 1759, 1836, 2191, 2235, 2504], 'best': [1575], 'determined': [1578], 'evaluated': [1580, 2010, 2050, 2227, 2804], 'assay,': [1584], 'least': [1599, 2148, 2178], 'tracers': [1601], 'validation.': [1604], 'further': [1612], 'characterize': [1613], 'properly.The': [1615], 'finding': [1618, 2112], 'measuresIn': [1620], '1970s': [1622], '1990s,': [1624], 'single-point': [1625], 'measurements': [1626, 1686, 3288], 'reversal': [1629, 1679, 1731, 1763, 1896, 1913, 1930, 1948, 2034, 2078, 3092], 'common,': [1633], 'providing': [1634, 2848], 'fold': [1638], 'reversal,': [1639], 'factors': [1641, 1780], 'percentage': [1643], 'reversal).': [1644], 'One': [1645], 'values': [1650, 1839, 2042, 2192, 2505], 'rather': [1652], 'incomparable': [1653], 'each': [1655, 1845], 'other,': [1656], 'barely': [1659, 1918], 'without': [1665], 'accepting': [1666], '(mathematical)': [1668], 'errors.': [1669], 'within': [1671, 1724, 2294], 'extensively': [1683], 'multiple-point': [1685], 'transporter-inhibiting': [1691], 'feature': [1692], '(IC50)': [1696, 1958], 'its': [1698, 3083], 'capability': [1699, 2000], 'reverse': [1701, 2514], 'detailed': [1706], 'analysis': [1707, 4320, 4542], 'important': [1715, 2207], 'emerged': [1720, 2280], 'introduced': [1723], '2': [1727], 'years:': [1728], 'half-maximal': [1730], 'concentration': [1732, 1739, 1975, 2203, 2699], '(EC50)': [1733, 1824], '[16–19].': [1734], 'EC50': [1736, 1838], 'gives': [1737, 1872, 2315, 3792], 'an': [1741, 1771, 1888, 1983, 2443, 3474], 'half-maximally': [1747], 'sensitize': [1748, 4350], 'transporter-expressing': [1750], 'cells,': [1752], 'interpreted': [1756], 'equivalent': [1760], 'assays.': [1764], 'deduced': [1769], 'inverse-sigmoid': [1772], 'curve': [1773], 'when': [1776], 'plotting': [1777], 'concentration.': [1789], 'Principally,': [1790], 'exist': [1797], 'pelitinib,': [1805, 2523], 'vatalanib)': [1808, 2526], '[20–22],': [1809], 'final': [1812, 1821], 'step': [1813, 2435], 'rows': [1815], '(raw)': [1817], 'comparable': [1822], 'taken': [1829, 2477], 'except': [1830], '[16–18].': [1835], 'validate': [1844], 'other.': [1846], 'value': [1849, 1857], 'discriminates': [1850, 1858], 'nonpotent,': [1854], 'second': [1856], '(usually)': [1860], 'effective': [1864], 'noneffective': [1866], 'cells.': [1869, 3324, 3764], 'Correlating': [1870], 'both': [1871, 2530], 'answer': [1873], 'questions:': [1876], 'surrogate': [1881], 'fluorescence': [1886], 'intensity)': [1887], 'adequate': [1889], 'efficacy': [1892, 3315, 4436], '(prediction)': [1893], 'assays?;': [1897], 'structure–activity': [1901], 'relationships': [1902], '(SAR)': [1903], 'obtained': [1904], 'reflect': [1909], 'assays?': [1914], 'validation': [1916], 'reported': [1919, 1942, 2374], '(pyrrolopyrimidines': [1923], 'daunorubicin': [1927], 'daunorubicin)': [1934], '[23].': [1935], 'A': [1936, 3277, 3280, 3338, 3745, 3987], 'third': [1937], 'up': [1938, 2616], 'now': [1940, 2618], 'never': [1941], 'time-dependency': [1945], 'vitro.': [1950], 'Besides': [1951], 'reversed': [1959], 'concentration-dependently': [1960], '(EC50),': [1965, 2029], 'highlighted': [1970], 'whether': [1971], 'low,': [1973], '(≤EC50)': [1976], 'agent': [1985, 1996, 3319, 3622], 'time-dependently': [1986], 'kills': [1987], 'efficiently': [1991], 'alone.': [1997], 'Finally,': [1998], 'up-': [2006], 'down-regulate': [2008], 'western': [2015], 'blot': [2016], 'PCR)': [2018], 'assessed.': [2021], 'measures:': [2024], 'IC50,': [2026], 'concentration-': [2028], 'time-dependent': [2032], 'cross-correlation': [2039], '‘side': [2046], 'effects’': [2047], 'induction': [2054], 'help': [2056], 'significantly:': [2057], 'feed': [2060], 'approaches': [2063, 2705], 'similarity': [2066], 'search': [2067], 'pharmacophore': [2069], 'modeling)': [2070], 'purpose': [2072], 'scaffolds': [2076], 'transporter-mediated': [2081, 3215], 'silico': [2085], 'screenings,': [2086], 'assist': [2090], 'decision': [2093], 'process': [2094], 'go': [2096, 2748], 'target(s)In': [2115], 'earlier': [2116], 'assessed': [2126], 'principle': [2131], 'holds': [2132], 'true': [2133], 'research:': [2138], 'highlighting': [2140], 'testing': [2144], 'others': [2152], 'is)': [2156], 'omitted,': [2158], 'needs': [2160], 'changed.': [2163], 'routinely': [2168], 'well': [2175, 2481], 'Determination': [2189], 'if': [2195], 'single-digit': [2198], 'double-digit': [2201], 'micromolar': [2202], 'critical': [2210, 2531], 'features': [2211], 'inhibition.': [2219], 'Until': [2220, 2494], 'now,': [2221, 2495], 'approximately': [2222, 2266, 2497], '800': [2223], 'definite': [2234, 2503], 'values,': [2236], 'tenth': [2239], 'revealed': [2242], 'triple': [2244, 2499], 'Less': [2251], 'exerted': [2254], 'below': [2262, 2271], '10': [2263, 4723], 'μM,': [2264], 'ten': [2267], 'activities': [2270], '5': [2272], 'μM.': [2273], 'science,': [2288], 'increasingly': [2291], 'past': [2296], 'couple': [2297], '[5,24,25].Multi-target': [2300], 'MDRSimultaneously': [2311], 'targeting': [2312, 4670], 'reasons:': [2320], 'proven': [2325], '(ABCB1,': [2332, 2463], 'ABCG2)': [2335], 'might': [2336, 2383], 'line': [2343], '(inherent': [2344], 'co-expression)': [2345], '[5,6].': [2346], 'Since': [2347], 'differing': [2350], 'preferences,': [2352], 'extends': [2355], '(=': [2358], 'agent)': [2360], 'increases': [2363, 2561], 'chemotherapeutics': [2366], 'downregulation': [2376], 'compensated': [2385], 'upregulation': [2387], 'another': [2389], '(triggered': [2390], 'upregulation)': [2391], '[26–28],': [2392], '(partially)': [2399], 'overlapping': [2400], 'range.': [2402], 'Considering': [2403], 'ability': [2409, 2657], 'regulate': [2411, 3819], 'maintain': [2421], 'supplementary': [2426], 'compensatory': [2428], '(over)expression,': [2431], 'logical': [2434], 'counteract': [2438], 'designing': [2442], 'affects': [2446], 'putatively': [2448, 2837], 'upregulated': [2449, 3992], 'transporters.': [2450], 'includes': [2452, 2953, 4781], 'ABCG2).': [2466], 'research,': [2469], 'MDR-relevant': [2471], 'ABCB4': [2483], 'ABCC2-5)': [2485], 'extend': [2487], 'interaction': [2489, 4184], 'inhibitors.': [2493], '80': [2498], 'ABCB1/ABCC1/ABCG2': [2500], 'exist,': [2506], 'five': [2509], 'shown': [2512], 'ABCB1-,': [2515], 'ABCC1-': [2516], 'ABCG2-mediated': [2518], '[16,18,20–22].': [2527], 'Consideration': [2528], '(IC50': [2533], 'EC50)': [2535], 'double-tracked': [2539], 'recourse': [2543], 'knowledge': [2547], 'today': [2550], 'bring': [2552], 'promising': [2555, 4378], 'clinic,': [2559], 'real': [2566], 'breakthrough.Multi-target': [2568], 'activators:': [2569], 'field': [2572], "Alzheimer's": [2574, 2652, 2778, 2880, 3917, 3994], 'diseaseWithin': [2575], 'play': [2586], 'crucial': [2588], 'Aβ': [2591, 2625, 2649], 'clearance': [2592], 'blood–brain': [2595, 4007], 'barrier': [2596, 4008], '[29].': [2597], 'Strikingly,': [2598], 'context': [2605], 'ones': [2621], 'direct': [2624], 'protein': [2626, 3413, 3480, 3556, 3594, 3725, 3968, 4038, 4343], '[30–32].': [2628], 'concept': [2632], 'science': [2636], 'activators': [2642, 2712, 2740, 4034], 'pumps': [2646], 'lessen': [2648], 'burden': [2650], 'disease-affected': [2653], 'brains.': [2654], 'activate': [2659], 'demonstrated': [2663], '[33].': [2668], 'As': [2669], 'exert': [2672, 2721], 'biphasic': [2681], '(activation': [2683], 'concentrations': [2686], 'higher': [2690], 'concentrations)': [2691], '[33],': [2692], 'full-blown': [2694], 'characterization': [2696], 'needed.': [2702], 'With': [2703, 2790], 'classify': [2707], 'less': [2710], 'starting': [2714], 'activation': [2722], 'bulk': [2725], 'generated': [2730], 'elucidate': [2732], 'action': [2736], 'SAR': [2738], 'general.Conclusion:': [2745], 'here?Multi-target': [2750], '(clinical)': [2757], 'importance,': [2758], 'illnesses': [2766], 'incidence': [2769], 'aging': [2771], 'society': [2772], 'disease),': [2779], 'pharmacokinetics': [2787], 'drugs.': [2789], 'approaches,': [2792], 'target': [2794], 'preferences': [2795], 'respect': [2801], 'elucidated.': [2809], 'provides': [2811], 'steps:': [2819], 'generation': [2821], 'chemical': [2826], 'activators)': [2834], 'cancerous': [2842], 'neurodegenerative)': [2844], 'diseases;': [2845], 'serve': [2857], 'diagnostic': [2859], 'tools': [2860], 'basic': [2863], 'research': [2866, 3360], 'assessment)': [2868], 'disease.': [2881, 3918], 'We': [2882], 'just': [2884], 'beginning': [2887], 'comparison': [2893], 'backbone': [2903], 'particular': [2910], 'medicinal': [2913], 'chemistry': [2914], 'general.Financial': [2916], 'competing': [2918, 4746], 'interests': [2919, 4747], 'disclosureThe': [2920, 4748], 'authors': [2921, 4749], 'no': [2923, 4751], 'relevant': [2924, 4581, 4752], 'affiliations': [2925, 4753], 'financial': [2927, 2936, 2940, 4755, 4764, 4768], 'involvement': [2928, 4756], 'any': [2930, 4758], 'organization': [2931, 4585, 4759], 'entity': [2933, 4761], 'interest': [2937, 4765], 'conflict': [2941, 4769], 'subject': [2944, 4772], 'matter': [2945, 4773], 'materials': [2947, 4775], 'discussed': [2948, 4776], 'manuscript.': [2951, 4779], 'employment,': [2954, 4782], 'consultancies,': [2955, 4783], 'honoraria,': [2956, 4784], 'stock': [2957, 4785], 'ownership': [2958, 4786], 'options,': [2960, 4788], 'expert': [2961, 4789], 'testimony,': [2962, 4790], 'grants': [2963, 4791], 'patents': [2965, 4793], 'received': [2966, 4794], 'pending,': [2968, 4796], 'royalties.No': [2970, 4798], 'writing': [2971, 4799], 'assistance': [2972, 4800], 'utilized': [2974, 4802], 'production': [2977, 4805], 'manuscript.References1.': [2980], 'Adamska': [2981], 'A,': [2982, 3038, 3068, 3172, 3374], 'Falasca': [2983], 'M.': [2984, 3468, 3543, 3578, 4026], 'ATP-binding': [2985, 3177, 3847, 4162, 4248, 4575], 'cassette': [2986, 3151, 3178, 3848, 4163, 4249, 4576], 'progression': [2989], 'pancreatic': [2994], 'cancer:': [2995, 3081], 'forward?': [3000], 'World.': [3001], 'J.': [3002, 3229, 3262, 3492, 3528, 3563, 3597, 3671, 3919, 3942, 3972, 4012], 'Gastroenterol.': [3003], '24(9),': [3004], '3222–3238': [3005], '(2018).Crossref,': [3006, 3130, 3302, 3329, 3368, 3800, 3924], 'Medline,': [3007, 3033, 3061, 3100, 3131, 3199, 3235, 3269, 3303, 3330, 3369, 3398, 3430, 3455, 3498, 3534, 3569, 3603, 3638, 3676, 3711, 3771, 3829, 3865, 3894, 3925, 3947, 3978, 4017, 4048], 'CAS,': [3008, 3034, 3062, 3101, 3132, 3200, 3236, 3370, 3399, 3431, 3456, 3499, 3535, 3570, 3604, 3639, 3677, 3712, 3772, 3801, 3830, 3895, 3926, 3948, 3979, 4018, 4049], 'Google': [3009, 3035, 3063, 3102, 3133, 3167, 3201, 3237, 3270, 3304, 3331, 3371, 3400, 3432, 3457, 3500, 3536, 3571, 3605, 3640, 3678, 3713, 3773, 3802, 3831, 3866, 3896, 3927, 3949, 3980, 4019, 4050], 'Scholar2.': [3010], 'Szakacs': [3011, 3041], 'G,': [3012, 3042, 3206, 3651, 3689, 3836], 'Paterson': [3013], 'JK,': [3014], 'Ludwig': [3015], 'JA,': [3016], 'Booth-Genthe': [3017], 'C,': [3018, 3040, 3954], 'Gottesmann': [3019, 3114], 'MM.': [3020, 3115, 3380], 'Targeting': [3021, 3075], 'cancer.': [3025, 3124, 3669], 'Nat.': [3026, 3125], 'Rev.': [3027, 3126, 3195, 3426, 3451], 'Drug': [3028, 4517, 4618], 'Discov.': [3029], '5(3),': [3030], '219–234': [3031], '(2006).Crossref,': [3032], 'Scholar3.': [3036], 'Tamaki': [3037], 'Ierano': [3039], 'Robey': [3043, 3104], 'RW,': [3044, 3105], 'Bates': [3045, 3073, 3112], 'SE.': [3046, 3074], 'controversial': [3048], 'oncology.': [3055], 'Essay': [3056], 'Biochem.': [3057, 3706], '50(1),': [3058], '209–232': [3059], '(2011).Crossref,': [3060, 3977], 'Scholar4.': [3064], 'Amiri-Kordestani': [3065], 'L,': [3066], 'Basseville': [3067], 'Kurdziel': [3069], 'K,': [3070, 3460, 3503, 3539, 4024], 'Jojo': [3071], 'AT,': [3072, 3111], 'breast': [3078, 3559, 3591, 4340], 'lung': [3080, 3668, 4205, 4352, 4457], 'discriminating': [3082], 'importance': [3085], 'failure': [3088], 'studies.': [3093], 'Drug.': [3094], 'Resist.': [3095], 'Updat.': [3096], '15(0),': [3097], '50–61': [3098], '(2012).Crossref,': [3099, 3397, 3828], 'Scholar5.': [3103], 'Pluchino': [3106], 'KM,': [3107], 'Hall': [3108], 'MD,': [3109, 3869], 'Fojo': [3110], 'SE,': [3113], 'Revisiting': [3116], 'multidrug-resistant': [3123], 'Cancer': [3127, 3193, 3326, 3364, 3633, 4120], '18(7),': [3128], '452–464': [3129], 'Scholar6.': [3134], 'Liu': [3135, 3931], 'B,': [3136, 3439], 'Li': [3137], 'L-J,': [3138], 'Gong': [3139], 'X,': [3140], 'Zhang': [3141, 3143], 'W,': [3142], 'H,': [3144, 3983], 'Zhao': [3145], 'L.': [3146, 3212, 3309], 'Co-expression': [3147], 'binding': [3150, 4494], 'poor': [3156], 'acute': [3159], 'myeloid': [3160], 'leukemia.': [3161], 'Oncol.': [3162], 'Lett.': [3163, 3634], '15(5),': [3164], '6671–6677': [3165], '(2018).Medline,': [3166], 'Scholar7.': [3168], 'Yu': [3169], 'M,': [3170, 3208, 3574, 3776, 3807, 3952], 'Ocana': [3171], 'Tannock': [3173], 'IF.': [3174], 'Reversal': [3175], 'modulate': [3183], 'chemoresistance:': [3184], 'why': [3185], 'failed': [3188], 'provide': [3190], 'benefit?': [3192], 'Metastasis': [3194], '32(1–2),': [3196], '211–227': [3197], '(2013).Crossref,': [3198], 'Scholar8.': [3202], 'Beretta': [3203], 'GL,': [3204], 'Cassinelli': [3205], 'Pennati': [3207], 'Zuco': [3209], 'V,': [3210, 3240, 3466], 'Gatti': [3211], 'Overcoming': [3213], 'resistance:': [3217], 'multitargeting': [3226], 'Eur.': [3228, 3527, 3596], 'Med.': [3230, 3393, 3424, 3449, 3493, 3529, 3564, 3598, 3795], 'Chem.': [3231, 3394, 3494, 3530, 3565, 3599, 3796], '142,': [3232], '271–289': [3233], '(2017).Crossref,': [3234, 3454, 3568, 3602, 4047], 'Scholar9.': [3238], 'Zoufal': [3239], 'Mairinger': [3241], 'S,': [3242, 3307, 3741, 3778], 'Krohn': [3243, 3806, 3951], 'M': [3244, 3405], 'et': [3245, 3278, 3339, 3406, 3508, 3613, 3746, 3781, 3810, 3839, 3874, 3935, 3957, 3988], 'al.': [3246, 3279, 3340, 3407, 3509, 3614, 3747, 3782, 3811, 3840, 3875, 3936, 3958, 3989], 'Measurement': [3247], 'cerebral': [3249, 3997], 'wilt-type': [3254], 'APP/PS1-21': [3256], 'positron': [3259], 'emission': [3260], 'tomography.': [3261], 'Cereb.': [3263], 'Blood': [3264], 'Flow': [3265], 'Metab.': [3266], '0271678X19854541': [3267], '(2019).Crossref,': [3268, 3429, 3497, 3533, 3770], 'Scholar10.': [3271], 'Szabo': [3272], 'E,': [3273, 3376], 'Türk': [3274], 'D,': [3275, 3435, 3985], 'Telbisz': [3276], 'fluorescent': [3282], 'dye': [3283], 'parallel': [3287], 'ABCG2,': [3291], 'functions.': [3297], 'PLoS': [3298, 3823], 'ONE': [3299, 3824], '13(1),': [3300], 'e0190629': [3301], 'Scholar11.': [3305], 'Wu': [3306], 'Fu': [3308, 3652, 3690], 'Tyrosine': [3310], 'conventional': [3317, 3620], 'Mol.': [3325], '17(1),': [3327], '25': [3328], 'Scholar12.': [3332], 'Alemany': [3333], 'R,': [3334, 3464, 3743, 3932], 'Moura': [3335], 'DS,': [3336], 'Redondo': [3337], 'Nilotinib': [3341], 'coadjuvant': [3343], 'treatment': [3344], 'sarcomas:': [3350], 'Phase': [3352], 'I': [3353], 'Spanish': [3357], 'group': [3358], 'sarcoma.': [3362], 'Clin.': [3363, 3973], 'Res.': [3365, 3425, 3450], '24(21),': [3366], '5239–5249': [3367], 'Scholar13.': [3372], 'Palmeira': [3373], 'Sousa': [3375], 'Vasconcelos': [3377], 'MH,': [3378], 'Pinto': [3379], 'Three': [3381], 'decades': [3382], 'P-gp': [3384], 'inhibitors:': [3385], 'skimming': [3386], 'through': [3387], 'generations': [3389], 'scaffolds.': [3391], 'Curr.': [3392], '19(13),': [3395], '1946–2025': [3396], 'Scholar14.': [3401], 'SM,': [3403, 3462, 3541, 4022], 'Wiese': [3404, 3467, 3542, 3577, 4025], 'resistance-associated': [3412, 3555, 3724, 4037], '1': [3414, 3726, 4039, 4066], 'related': [3416, 3484], 'processes:': [3417], 'advances.': [3423], '39(1),': [3427], '176–264': [3428], 'Scholar15.': [3433], 'Pena-Solorzano': [3434], 'Stark': [3436], 'SA,': [3437], 'König': [3438], 'Sierra': [3440], 'CA,': [3441], 'Ochoa-Puentes': [3442], 'C.': [3443], 'ABCG2/BCRP:': [3444], 'nonspecific': [3447], 'modulators.': [3448], '37(5),': [3452], '987–1050': [3453], 'Scholar16.': [3458], 'Silbermann': [3459, 3502], 'Elshawadfy': [3463], 'Namasivayam': [3465], 'Identification': [3469], 'thienopyrimidine': [3471], 'scaffold': [3472, 4379], 'combined': [3488], 'approach.': [3491], '62(9),': [3495], '4383–4400': [3496], 'Scholar17.': [3501], 'Shah': [3504], 'CP,': [3505], 'Sahu': [3506], 'NU': [3507], 'Novel': [3510, 4117], 'chalcone': [3511], 'flavone': [3513], 'derivatives': [3514, 3749, 4028], 'proteins': [3523, 3552], '164,': [3531], '193–213': [3532], 'Scholar18.': [3537], 'Schmitt': [3540, 3715, 4021], '9-deazapurines': [3544], 'P-glycoprotein,': [3553], '1,': [3557], 'protein.': [3562], '60(21),': [3566], '8758–8780': [3567], 'Scholar19.': [3572], 'Krapf': [3573], 'Gallus': [3575], 'J,': [3576, 3903], 'Synthesis': [3579], 'biological': [3581], 'investigation': [3582], '2,4-substituted': [3584], 'quinazolines': [3585], '(ABCG2).': [3595], '139,': [3600], '587–611': [3601], 'Scholar20.': [3606], 'Dai': [3607], 'CL,': [3608], 'Liang': [3609], 'YJ,': [3610], 'Wang': [3611, 3648, 3686], 'YS': [3612], 'Sensitization': [3615], 'ABCG2-overexpressing': [3617, 3696], 'inhibiting': [3628], '279(1),': [3635], '74–83': [3636], '(2009).Crossref,': [3637, 4016], 'Scholar21.': [3641], 'To': [3642, 3680], 'KKW,': [3643, 3681], 'Poon': [3644, 3682], 'DC,': [3645, 3683], 'Wei': [3646, 3684], 'Y,': [3647, 3685], 'F,': [3649, 3687, 3901], 'Kin': [3650], 'L-W.': [3653, 3691], 'Pelitinib': [3654], '(EKB-569)': [3655], 'targets': [3656], 'up-retulation': [3658], 'induced': [3663], 'hyperthermia': [3665], 'eradicate': [3667], 'Br.': [3670], 'Pharmacol.': [3672, 3707, 3767], '172(16),': [3673], '4089–4106': [3674], '(2015).Crossref,': [3675, 3710, 3893], 'Scholar22.': [3679], 'Lin': [3688], 'Vatalanib': [3692], 'sensitizes': [3693], 'resistant': [3698, 4188, 4454], 'colon': [3699], 'hypoxia.': [3705], '97(1),': [3708], '27–37': [3709], 'Scholar23.': [3714], 'SM.': [3716], 'Purines': [3717], 'deazapurines': [3719], '(MRP1/ABCC1)-mediated': [3727], 'transport,': [3728], '[PhD': [3729], 'Thesis]': [3730], 'Friedrich-Wilhelms-Universität': [3732], 'Germany,': [3735], '57–58': [3736], '(2017).': [3737], 'http://hss.ulb.uni-bonn.de/2017/4900/4900.pdfGoogle': [3738], 'Scholar24.': [3739], 'Ranjbar': [3740], 'Khonkarn': [3742], 'Moreno': [3744], '5-oxo-hexahydroquinoline': [3748], 'MRP1': [3754], 'BCRP': [3756], 'overcome': [3759, 4675], 'Toxicol.': [3765], 'Appl.': [3766], '362,': [3768], '136–149': [3769], 'Scholar25.': [3774], 'Contino': [3775], 'Guglielmo': [3777], 'Perrone': [3779], 'MG': [3780], 'New': [3783, 4055], 'tretrahydroisoquinoline-based': [3784], 'P-glycoprotein': [3785, 4671], 'decoration': [3787], 'biphenyl': [3790], 'core': [3791], 'ligands.': [3794], 'Comm.': [3797], '9(5),': [3798], '862–869': [3799], 'Scholar26.': [3803], 'Schumacher': [3804], 'T,': [3805], 'Hofrichter': [3808, 3955], 'J': [3809, 3956, 4680], 'B1,': [3814], 'C1': [3815], 'G2': [3817], 'differentially': [3818], 'neuroregeneration': [3820], 'mice.': [3822, 3971], '7(4),': [3825], 'e35613,': [3826], '1–14': [3827], 'Scholar27.': [3832], 'Bernstein': [3833], 'HG,': [3834], 'Hölzl': [3835], 'Dobrowolny': [3837], 'H': [3838], 'Vascular': [3841], 'extravascular': [3843], 'distribution': [3844], 'aged': [3854], 'human': [3855, 4351, 4579], 'brain': [3856, 3995], 'pituirary.': [3858], 'Mech.': [3859], 'Ageing': [3860], 'Dev.': [3861, 3890], '141,': [3862], '12–21': [3863], '(2014).Crossref,': [3864], 'Scholar28.': [3867], 'Samant': [3868], 'Jackson': [3870], 'CM,': [3871], 'Felix': [3872], 'CL': [3873], 'Multi-drug': [3876], 'enhances': [3881], 'murine': [3882], 'ventral': [3883], 'prostate': [3884], 'stem/progenitor': [3885], 'differentiation.': [3887], 'Stem': [3888], 'Cells': [3889, 4510], '24(10),': [3891], '1236–1251': [3892], 'Scholar29.': [3897], 'Pereira': [3898], 'CD,': [3899], 'Martins': [3900], 'Wiltfang': [3902], 'da': [3904], 'Gruz': [3905], 'E': [3906], 'Siilva': [3907], 'OAB,': [3908], 'Rebelo': [3909], 'S.': [3910], 'key': [3914], 'players': [3915], 'Alzheimers': [3920], 'Dis.': [3921], '61(2),': [3922], '463–485': [3923], 'Scholar30.': [3928], 'Lam': [3929], 'FC,': [3930], 'Lu': [3933], 'P': [3934], 'β-amyloid': [3937], 'mediated': [3939], 'P-glycoprotein.': [3941], 'Neurochem.': [3943], '76(4),': [3944], '1121–1128': [3945], '(2001).Crossref,': [3946], 'Scholar31.': [3950], 'Lange': [3953], 'Cerebral': [3959], 'amyloid-β': [3960], 'proteostasis': [3961], 'regulated': [3963], 'Invest.': [3974], '121(10),': [3975], '3924–3931': [3976], 'Scholar32.': [3981], 'Xiong': [3982], 'Callaghan': [3984], 'Jones': [3986], 'amyloid': [3998], 'angiopathy': [3999], 'my': [4001], 'act': [4002], 'gatekeeper': [4004], 'Aβ(1–40)': [4010], 'peptides.': [4011], 'Neurosci.': [4013], '29(17),': [4014], '5463–5475': [4015], 'Scholar33.': [4020], 'Pyrrolopyrimidine': [4027], 'purine': [4030], 'analogs': [4031], '(MRP1).': [4040], 'Biochim.': [4041], 'Biophys.': [4042], 'Acta': [4043], 'Biomembr.': [4044], '1859(1),': [4045], '69–79': [4046], 'ScholarFiguresReferencesRelatedDetailsCited': [4051], 'ByIndole': [4052], 'Derivatives': [4053, 4625, 4654], 'Structural': [4056, 4545], 'Class': [4057], 'Potent': [4059], 'Antiproliferative': [4061], 'Inhibitors': [4062, 4283, 4551, 4629], 'Monocarboxylate': [4064], 'Transporter': [4065, 4141, 4471, 4657], '(MCT1;': [4067], 'SLC16A1)30': [4068], 'December': [4069, 4097, 4325, 4362], '2022': [4070, 4098, 4145, 4167, 4208, 4231, 4255, 4275, 4311], '|': [4071, 4099, 4126, 4146, 4168, 4209, 4232, 4256, 4276, 4312, 4327, 4364, 4403, 4423, 4475, 4522, 4565, 4616, 4639, 4661, 4695], 'Journal': [4072, 4101, 4443, 4459, 4476, 4496, 4567, 4640], 'Chemistry,': [4075, 4290, 4385, 4479, 4499, 4643, 4698], 'Vol.': [4076, 4105, 4128, 4151, 4171, 4191, 4212, 4239, 4261, 4279, 4291, 4314, 4329, 4346, 4368, 4386, 4407, 4425, 4447, 4462, 4480, 4500, 4526, 4548, 4571, 4620, 4644, 4663, 4699, 4703], '66,': [4077], '1Why': [4079], 'Do': [4080], 'Dietary': [4081], 'Flavonoids': [4082], 'Have': [4083], 'Promising': [4085], 'Effect': [4086], 'Enhancers': [4088], 'Anthracyclines?': [4090], 'Hydroxyl': [4091], 'Substituents,': [4092], 'Bioavailability': [4093], 'Biological': [4095], 'Activity26': [4096], 'International': [4100, 4566], 'Molecular': [4103, 4257, 4569], 'Sciences,': [4104, 4570], '24,': [4106], '1The': [4108], 'More': [4109], 'Better—Investigation': [4111], 'Polymethoxylated': [4113], 'N-Carboranyl': [4114], 'Quinazolines': [4115], 'Hybrid': [4118], 'Breast': [4119], 'Resistance': [4121, 4398, 4418], 'Protein': [4122, 4216], 'Inhibitors10': [4123], 'January': [4124, 4254], '2023': [4125], 'Pharmaceutics,': [4127, 4461], '15,': [4129], '1ATP': [4131], 'Mimetic': [4132], 'Attack': [4133], 'Nucleotide-Binding': [4136], 'Domain': [4137], 'Overcome': [4139], 'Mediated': [4142], 'Chemoresistance28': [4143], 'November': [4144, 4563], 'ACS': [4147], 'Letters,': [4150], '13,': [4152, 4213], '12A': [4154], 'curated': [4155], 'binary': [4156], 'pattern': [4157, 4319, 4541], 'multitarget': [4158, 4322], 'dataset': [4159], 'focused': [4161], 'inhibitors26': [4165], 'July': [4166, 4637, 4659, 4724], 'Scientific': [4169], 'Data,': [4170], '9,': [4172], '1Triterpenes': [4174], 'Momordica': [4176], 'balsamina': [4177], '(African': [4178], 'pumpkin):': [4179], 'synergistic': [4183], 'cellsPhytochemistry,': [4190], '203Inhibitors': [4192], 'overcame': [4197], 'topoisomerase': [4200], 'small': [4203, 4455], 'cancer20': [4206], 'June': [4207, 4230, 4720], 'Thoracic': [4210], 'Cancer,': [4211], '15Unconventional': [4215], 'Secretion': [4217], 'Brain': [4219], 'Tumors': [4220], 'Biology:': [4221], 'Enlightening': [4222], 'Mechanisms': [4224], 'Tumor': [4226, 4308, 4509], 'Survival': [4227], 'Progression15': [4229], 'Frontiers': [4233, 4404], 'Cell': [4235], 'Developmental': [4237], 'Biology,': [4238], '10Research': [4240], 'advances': [4241], 'pharmaceuticals': [4246], 'autoimmune': [4252], 'diseases16': [4253], 'Cellular': [4259], 'Biochemistry,': [4260, 4446], '477,': [4262], '4Momordica': [4264], 'balsamina:': [4265], 'phytochemistry': [4266], 'gifted': [4272], 'species8': [4273], 'February': [4274, 4520, 4693], 'Phytochemistry': [4277], 'Reviews,': [4278], '21,': [4280, 4572], '2MDR': [4282], 'Anticancer': [4285], 'TherapyAnti-Cancer': [4286], 'Agents': [4287], '22,': [4292], '7Infigratinib': [4294], '(BGJ': [4295], '398),': [4296], 'Pan-FGFR': [4298], 'Inhibitor,': [4299], 'Targets': [4300], 'P-Glycoprotein': [4301], 'Increases': [4303], 'Chemotherapeutic-Induced': [4304], 'Mortality': [4305], 'Multidrug-Resistant': [4307], 'Cells3': [4309], 'March': [4310, 4473], 'Biomedicines,': [4313], '10,': [4315], '3Structural': [4317], 'feature-driven': [4318], 'modulator': [4323], 'landscapes9': [4324], '2021': [4326, 4363, 4402, 4422, 4474, 4521], 'Bioinformatics,': [4328], '38,': [4330], '5A': [4332], 'porphyrin': [4334], 'substrate-based': [4337], '(BCRP/ABCG2)Chemico-Biological': [4344], 'Interactions,': [4345], '351Bixin': [4347], 'fucoxanthin': [4349], 'cervical': [4355], 'cisplatin': [4359], 'vitro18': [4361], 'BMC': [4365], 'Research': [4366], 'Notes,': [4367], '14,': [4369, 4426], '1Synthesis': [4371], 'indole-thiazolidinone': [4374], 'hybrid': [4375], 'structures': [4376], 'potentialBioorganic': [4382], '50Research': [4387], 'Progress': [4388], 'Functions': [4391], 'Mechanism': [4393], 'circRNA': [4395], 'Cisplatin': [4397], 'Tumors9': [4400], 'September': [4401, 4729, 4734], 'Pharmacology,': [4406], '12Exploring': [4408], 'Monoterpene': [4410], 'Indole': [4411], 'Alkaloid': [4412], 'Scaffold': [4413], 'Reversing': [4415], 'P-Glycoprotein-Mediated': [4416], 'Multidrug': [4417, 4648], 'Cancer28': [4420], 'August': [4421], 'Pharmaceuticals,': [4424], '9Current': [4428], 'methodologies': [4429], 'refine': [4431], 'bioavailability,': [4432], 'delivery,': [4433], 'therapeutic': [4435], 'plant': [4438], 'flavonoids': [4439], 'treatmentThe': [4442], 'Nutritional': [4445], '94MRP1-targeted': [4448], 'near': [4449], 'infrared': [4450], 'photoimmunotherapy': [4451], 'cancerInternational': [4458], '604C@PA:': [4463], 'Computer-Aided': [4464], 'Pattern': [4465], 'Analysis': [4466], 'Predict': [4468], 'Multitarget': [4469], 'Inhibitors16': [4472], '64,': [4481], '6Rational': [4483], '6-substituted': [4487], '4-anilino-2-phenylpyrimidines': [4488], 'exploration': [4490], 'siteEuropean': [4495], '212Activity': [4501], 'Cordycepin': [4503], 'From': [4504], 'Cordyceps': [4505], 'sinensis': [4506], 'Against': [4507], 'Drug-Resistant': [4508], 'Determined': [4512], 'Gene': [4514], 'Sensitivity': [4518], 'Profiling8': [4519], 'Natural': [4523], 'Product': [4524], 'Communications,': [4525], '16,': [4527], '2Scaffold': [4529], 'fragmentation': [4530], 'substructure': [4532], 'hopping': [4533], 'reveal': [4534], 'potential,': [4535], 'robustness,': [4536], 'computer-aided': [4540], '(C@PA)Computational': [4543], 'Biotechnology': [4546], 'Journal,': [4547], '19Combination': [4549], 'USP7': [4553], 'PLK1': [4555], 'Strong': [4558], 'Synergism': [4559], 'Paclitaxel': [4561], 'Resistance16': [4562], '2020': [4564, 4615, 4638, 4660, 4694], '22Vesicular': [4574], 'disease:': [4580], 'aspects': [4582], 'developmentKatja': [4589], 'Stefan,': [4590, 4678], 'Lionel': [4591], 'Yi': [4592], 'Wen': [4593], 'Leck,': [4594], 'Vigneshwaran': [4595], 'Namasivayam,': [4596], 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