Dysregulation of cystathionine γ‐lyase promotes prostate cancer progression and metastasis

Name: Work Video:
Duration: 3 min 30 s
Yi‐Hsiang Wang; Jo‐Ting Huang; Wen‐Ling Chen; Rong‐Hsuan Wang; Ming‐Chien Kao; Yan‐Ru Pan; Shih‐Hsuan Chan; Kuo‐Wang Tsai; Hsing‐Jien Kung; Kai‐Ti Lin; Lu‐Hai Wang
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3832, 3837, 4355], 'summary': [951], 'the': [953, 1042, 1082, 1103, 1127, 1179, 1182, 1192, 1242, 1248, 1253, 1302, 1307, 1380, 1610, 1704, 1715, 1733, 1745, 1752, 1768, 1783, 1788, 1806, 1811, 1816, 1831, 1849, 1895, 1912, 1932, 1973, 1977, 1987, 1990, 2004, 2009, 2027, 2116, 2125, 2141, 2147, 2220, 2307, 2337, 2354, 2369, 2421, 2427, 2439, 2456, 2496, 2503, 2565, 2641, 2658, 2662, 2691, 2705, 2790, 2804, 2834, 2848, 2912, 2915, 2934, 2984, 3036, 3049, 3055, 3099, 3124, 3159, 3205, 3228, 3240, 3247, 3256, 3287, 3317, 3325, 3346, 3382, 3393, 3402, 3416, 3440, 3443, 3488, 3494, 3516, 3549, 3562, 3574, 3592, 3606, 3663, 3679, 3693, 3703, 3725, 3745, 3760, 3783, 3854, 3857, 3876, 3927, 3987, 4003, 4017, 4094, 4121, 4163, 4177, 4209, 4271, 4304, 4322, 4328, 4336, 4369], 'editorial': [954, 958], 'decision': [955, 959], 'including': [957, 993, 1350, 2163, 2275, 3542], 'letters,': [960], 'reviewer': [961], 'comments': [962], 'responses': [965], 'feedback.': [967], 'ToolsAdd': [968], 'favoritesDownload': [970], 'CitationsTrack': [971], 'CitationsPermissions': [972], 'ShareFacebookTwitterLinked': [973], 'InMendeleyWechatReddit': [974], 'Figures': [975], '&': [976], 'Info': [977], 'Abstract': [978], 'Hydrogen': [979, 1329], 'sulfide': [980, 1330, 2520], '(H2S),': [981, 1331, 2521], 'an': [982, 1491, 1774, 2077, 3583, 3741], 'endogenous': [983, 2849, 4279], 'signaling': [984, 1150, 1338, 1624, 1821, 4255, 4361], 'gaseous': [985, 1163, 2517], 'molecule,': [986], 'is': [987, 1031, 1046, 1241, 1278, 1322, 1336, 1389, 1395, 2180, 2679, 2732, 3571, 3611, 3625, 3710, 4315, 4351], 'involved': [988, 2060], 'in': [989, 1033, 1048, 1087, 1098, 1102, 1115, 1126, 1167, 1220, 1226, 1247, 1260, 1273, 1346, 1377, 1497, 1525, 1540, 1555, 1572, 1609, 1650, 1665, 1682, 1703, 1751, 1777, 1797, 1815, 1844, 1848, 1868, 1911, 1926, 1952, 1979, 2061, 2084, 2121, 2129, 2146, 2156, 2182, 2192, 2203, 2210, 2219, 2247, 2263, 2293, 2388, 2426, 2461, 2524, 2567, 2650, 2670, 2697, 2712, 2735, 2745, 2851, 2999, 3054, 3067, 3155, 3170, 3214, 3219, 3281, 3322, 3336, 3365, 3386, 3397, 3401, 3412, 3433, 3462, 3515, 3531, 3537, 3548, 3566, 3591, 3643, 3654, 3673, 3684, 3714, 3724, 3786, 3930, 3986, 4062, 4124, 4282, 4300, 4342], 'various': [990, 3366], 'physiological': [991, 1348], 'activities,': [992], 'vessel': [994, 1354], 'relaxation,': [995], 'regulation': [996, 1351, 1508], 'cellular': [998, 1369], 'bioenergetics,': [999, 1511], 'inflammation,': [1000], 'angiogenesis.': [1002], 'By': [1003, 4363], 'using': [1004, 1960, 2438, 3035, 3123, 3178], 'xenograft': [1005, 1130, 1961], 'orthotopic': [1006, 1128, 1836, 1962, 2221], 'implantation': [1007, 1837, 1963], 'PC3': [1011, 1035, 1099, 1845, 1968, 2011, 2029, 2036, 2053, 2091, 2207, 2476, 2484, 2737, 2747, 2770, 2852, 3517, 3674, 3931, 3941, 3964, 4187, 4343], 'cells': [1012, 1100, 1117, 1543, 1547, 1675, 1693, 1846, 1870, 1929, 1951, 1969, 2001, 2020, 2092, 2186, 2208, 2217, 2326, 2332, 2477, 2485, 2535, 2562, 2585, 2598, 2627, 2674, 2723, 2748, 2775, 2865, 2950, 3399, 3414, 3435, 3499, 3504, 3518, 3540, 3675, 3685, 3694, 3726, 3788, 3796, 3813, 3821, 3884, 3910, 3932, 3942, 3965, 4065, 4071, 4128, 4142, 4188, 4302, 4344], 'subsequently': [1014, 1739, 2066], 'comparing': [1015], 'bone': [1016, 1274, 1308, 1318, 1862, 1953, 2023, 2045, 2211, 2614, 2862, 2968], 'metastatic': [1017, 1637, 2183, 2549, 2579], 'with': [1018, 1058, 1234, 1401, 1419, 1627, 1652, 1888, 2137, 2189, 2270, 2385, 2407, 2531, 2660, 2719, 2752, 2899, 3112, 3150, 3173, 3204, 3221, 3227, 3252, 3286, 3298, 3485, 3632, 3645, 3754, 3789, 3797, 3814, 3822, 3841, 3887, 3911, 3934, 3945, 3968, 4074, 4130, 4145, 4191, 4289, 4345], 'primary': [1019, 1119, 1852, 1872, 1957, 1991, 2005, 2048, 2471, 2855, 3192, 3215], 'tumor-derived': [1020, 2472, 2856], 'cells,': [1022, 2267, 2274, 2528, 2716, 3466, 4286, 4293], 'we': [1023, 1786, 1940, 2065, 2123, 2554, 2687, 3166, 3245, 3445, 3628, 3747, 4320], 'find': [1024], 'that': [1025, 1041, 1138, 1340, 1566, 1620, 1656, 1730, 1805, 1840, 2482, 2573, 2594, 2729, 3276, 3355, 3448, 3662, 3705, 3734, 4260], 'H2S-producing': [1026], 'enzyme': [1027, 2682, 3588, 3607, 3626], '(CTH)': [1030, 1154], 'upregulated': [1032, 1524, 1925, 2083], 'bone-metastatic': [1034, 1296, 1705, 1927, 2090, 2466, 2483, 2736, 2746], 'cells.': [1036, 2282, 2654, 2738], 'Clinical': [1037], 'data': [1038, 2415, 2443, 2571, 3043, 3128, 3660, 3732, 4030, 4234], 'further': [1039, 2636, 3446, 3618], 'reveal': [1040], 'expression': [1043, 1056, 1090, 1758, 1807, 1884, 1934, 2068, 2100, 2127, 2202, 2246, 2262, 2292, 2384, 2511, 2996, 3064, 3146, 3160, 3169, 3211, 3251, 3278, 3310, 3329, 3395, 3664, 4056, 4324], 'CTH': [1045, 1055, 1071, 1097, 1114, 1139, 1171, 1186, 1210, 1222, 1423, 1440, 1536, 1736, 1791, 1809, 1843, 1867, 1886, 1902, 1923, 2102, 2120, 2126, 2142, 2178, 2200, 2238, 2245, 2261, 2383, 2411, 2417, 2460, 2513, 2678, 2743, 2850, 2998, 3045, 3066, 3116, 3148, 3162, 3168, 3213, 3250, 3277, 3309, 3321, 3328, 3356, 3369, 3385, 3391, 3409, 3426, 3451, 3470, 3481, 3489, 3520, 3530, 3536, 3565, 3587, 3610, 3621, 3630, 3640, 3696, 3709, 3735, 3765, 3771, 3784, 3790, 3798, 3815, 3823, 3912, 3928, 4055, 4122, 4247, 4297, 4346], 'elevated': [1047, 1225, 2181], 'late-stage': [1049, 1227], 'patients,': [1052], 'higher': [1054, 1436, 2488, 2548, 2578], 'correlates': [1057, 1626, 2188, 2751], 'poor': [1059, 1892, 2190, 2386, 2756, 3153, 3312, 3331], 'survival': [1060, 1649, 1893, 2191, 2387, 2398, 2757, 3107, 3154, 3254, 3313, 3332, 4262], 'from': [1061, 1266, 1426, 1446, 1468, 1486, 1659, 1949, 1956, 2003, 2021, 2044, 2051, 2093, 2420, 2878, 3018, 3048, 3255, 3295, 3345, 3392, 3811, 4327], 'The': [1062, 1641, 1709, 1835, 2227, 2413, 2433, 2510, 2902, 2995, 3015, 3030, 3041, 3062, 3118, 3188, 3199, 3210, 3804, 3844, 4256], 'Genome': [1064], 'Atlas': [1065], '(TCGA)': [1066], 'RNA-seq': [1069, 2414, 3042, 3259, 3348], 'datasets.': [1070, 3260], 'NF-κB': [1073, 1083, 1183, 1623, 1642, 1660, 1713, 1720, 1756, 1779, 1832], 'nuclear': [1074, 1198, 1721], 'translocation': [1075], 'through': [1076, 1148, 1379, 1430, 1504, 3740, 4251, 4268, 4359], 'H2S-mediated': [1077], 'sulfhydration': [1078, 1180, 1193, 1202, 1392, 1741, 1765, 1827, 4269, 4281, 4305, 4314], 'on': [1079, 1494, 1742, 1767, 1828, 3600, 3639, 3649], 'cysteine-38': [1080, 1743, 1829], 'p65': [1084, 1201, 1746, 1769, 1833, 4272, 4280, 4307], 'subunit,': [1085], 'resulting': [1086, 1750, 1814], 'increased': [1088, 1810, 1876, 1883, 2523, 2600, 2696, 3217, 3280, 3403, 3514, 4278], 'IL-1β': [1089, 1207, 1702, 1820, 4350, 4367], 'H2S-induced': [1092], 'cell': [1093, 1204, 1514, 1538, 1560, 1613, 1824, 1944, 2073, 2132, 2150, 2160, 2497, 2816, 2876, 3372, 3429, 3458, 3474, 3532, 3553, 3567, 3576, 3601, 3615, 3623, 3671, 3680, 3738, 3767, 3809, 4058, 4249, 4261], 'invasion.': [1094, 3616], 'Knockdown': [1095, 3424, 3534, 4245], 'results': [1101, 2659], 'suppression': [1104, 1850, 3550], 'tumor': [1106, 1120, 1212, 1495, 1853, 1873, 1950, 1992, 2000, 2019, 2224, 3182], 'growth': [1107, 1121, 1496, 1539, 1854, 1874, 1988, 3495], 'distant': [1109, 1218, 1918, 1995, 2606], 'metastasis,': [1110, 1863, 1939, 2064], 'while': [1111, 1422, 1535, 1864, 3467, 4294], 'overexpression': [1112, 1865, 3791, 3816], 'DU145': [1116, 1869, 2281], 'lymph': [1123, 1859, 1879, 2611, 2963], 'node': [1124, 1860, 1880], 'implanted': [1129, 2222, 2854], 'mouse': [1131, 1964, 2955], 'model.': [1132], 'Together,': [1133], 'our': [1134, 1898, 3731], 'findings': [1135], 'provide': [1136], 'evidence': [1137], 'generated': [1140, 1740, 3629], 'H2S': [1141, 1188, 1366, 1394, 1414, 1425, 1445, 1460, 1484, 1587, 1738, 1812, 1906, 2644, 2872, 2905, 3404, 3419, 3773, 3805, 3847], 'IL-1β/NF-κB': [1149], 'pathways.': [1151], 'Synopsis': [1152], 'Cystathionine-γ-lyase': [1153], 'its': [1156, 1197, 1793, 1904, 2515, 3655], 'catalyzed': [1157, 1467], 'product': [1158], 'hydrogen': [1159, 2519], 'sulfide,': [1160], 'known': [1162, 4352], 'transmitter,': [1164], 'are': [1165, 1224, 1268, 1298, 2444, 2833, 2971, 3021, 3074, 3129, 3641, 4031, 4235], 'dysregulated': [1166], 'cancer.': [1169], 'Increased': [1170, 1549, 3145], 'activity': [1172, 1722, 2874, 3608, 3657, 3707], 'via': [1178, 1206], 'subunit': [1184, 1747, 1770, 4273], 'p65.': [1185], 'induces': [1187], 'production': [1189, 2906, 3417, 3806, 3848], 'stimulate': [1191], 'p65,': [1195], 'promoting': [1196, 1666, 3722], 'translocation.': [1199], 'CTH-dependent': [1200], 'triggers': [1203], 'invasion': [1205, 1825, 2491, 2763, 2783, 3432, 3461, 3477, 3510, 3556, 3570, 3595, 3681, 3721, 3777, 3900, 3959, 3982, 4061, 4088, 4157, 4204, 4250], 'mediated': [1208, 4267], 'signaling.': [1209, 4330], 'growth,': [1213], 'angiogenesis': [1214], 'lymphangiogenesis': [1216], 'vivo.': [1221], 'levels': [1223, 2128, 2703, 3929, 4123], 'patients': [1230, 1651, 2406, 3111, 3220, 3297, 3644], 'negatively': [1232], 'correlated': [1233, 1887, 3149, 3202], 'good': [1235], 'prognosis.': [1236], 'Introduction': [1237], 'Prostate': [1238], '(PC)': [1240], 'most': [1243], 'common': [1244, 3572], 'male': [1245], 'malignancy': [1246], 'United': [1249], 'States': [1250], '1': [1251, 2942, 3139], 'sixth': [1254], 'leading': [1255, 1305], 'cause': [1256], 'deaths': [1259, 1265], 'men': [1261], 'worldwide': [1262], '2.': [1263, 3770], 'Most': [1264], 'PC': [1267, 1297, 1311, 1321, 1628, 1653, 1667, 1674, 1692, 1798, 1889, 1915, 1928, 1938, 2131, 2159, 2753, 3068, 3092, 3110, 3156, 3164, 3171, 3206, 3258, 3265, 3282, 3296, 3371, 3387, 3539, 3575, 4318], 'caused': [1269], 'metastases,': [1271], 'especially': [1272], '3.': [1275], 'Bone': [1276], 'virtually': [1279], 'incurable': [1280], 'can': [1282], 'lead': [1283], 'pain,': [1285], 'pathological': [1286], 'fractures,': [1287], 'nerve': [1288], 'compression': [1289], 'syndromes,': [1290], 'hypercalcemia.': [1292], 'Current': [1293], 'treatments': [1294], 'mainly': [1299, 1371], 'palliative,': [1300], 'underlying': [1303], 'mechanism': [1304, 1776, 3762], 'remains': [1312, 1584], 'unclear.': [1313], 'Novel': [1314], 'therapeutic': [1315, 1909], 'strategy': [1316], 'against': [1317], 'urgently': [1323], 'required': [1324, 3612, 4316], 'improve': [1326], 'patient': [1327], 'outcomes.': [1328], 'rotten': [1333], 'egg-smelling': [1334], 'gas,': [1335], 'molecule': [1339], 'acts': [1341], 'as': [1342, 1398, 1598, 1907, 2008, 2016, 2018, 2424, 2529, 2609, 2717, 2894, 3052, 3076, 3225, 3284, 3690, 3836, 4287], 'critical': [1344], 'mediator': [1345], 'multiple': [1347], 'processes,': [1349], 'blood': [1353], 'vasodilation': [1355], '4-6,': [1356], 'cardiac': [1357], 'response': [1358], 'ischemia/reperfusion': [1360], 'injury': [1361], '7,': [1362], 'inflammation': [1364], '8.': [1365], 'modulates': [1367], 'diverse': [1368], 'processes': [1370], 'modifying': [1373], 'specific': [1374], 'cysteine': [1375, 1420, 1427, 1473], 'residues': [1376], 'proteins': [1378, 3752], 'formation': [1381], 'persulfide': [1384], '(-SSH)': [1385], 'bond;': [1386], 'modification': [1388, 1766], 'called': [1390], 'protein': [1391, 2099, 2350, 2363, 2638, 3736], '9.': [1393], 'produced': [1396], 'endogenously': [1397], 'metabolite': [1400, 1466], 'β-synthase': [1403], '(CBS),': [1404], '(CTH),': [1407, 2081], '3-mercaptopyruvate': [1409, 1463], 'sulfurtransferase': [1410], '(3MST).': [1411], 'CBS': [1412, 1455, 1522, 2647, 2665], 'catalyzes': [1413], 'beta-replacement': [1417], 'reaction': [1418, 2898, 3840], '10,': [1421], 'produces': [1424, 1459], 'water': [1429], 'alpha': [1431], 'beta': [1433], 'elimination.': [1434], 'In': [1435, 1782, 2655, 3744], 'concentration': [1437, 2346], 'homocysteine,': [1439], 'also': [1441, 2688, 3334, 3546, 4276], 'generates': [1442], 'homolanthionine': [1443], 'two': [1447, 2463, 2643, 3453], 'homocysteines': [1448], 'gamma-replacement': [1450], 'reactions': [1451], '11.': [1452], 'Other': [1453], 'than': [1454, 2551, 2581], 'CTH,': [1457, 2288, 2661, 3244], '3MST': [1458, 1552, 1567, 2291, 2667], 'processing': [1462], '(3MP),': [1464], 'L-': [1469], 'D-cysteine': [1471], 'aminotransferase': [1474], '(CAT)': [1475], 'D-amino': [1477], 'acid': [1478], 'oxidase': [1479], '(DAO),': [1480], 'respectively': [1481], '12-15.': [1482], 'Endogenous': [1483], 'derived': [1485], 'these': [1487, 2071, 2104], 'three': [1488], 'enzymes': [1489], 'plays': [1490], 'influential': [1492], 'role': [1493, 1571, 1700, 1789, 2118, 3361, 3383, 3528, 3563], 'variety': [1499], 'different': [1501, 2130, 3019, 3454], 'types': [1503, 2195], 'induction': [1505], 'angiogenesis,': [1507], 'mitochondrial': [1510], 'acceleration': [1512], 'cycle': [1515], 'progression,': [1516, 1629, 3165, 4319], 'anti-apoptosis': [1518], '16.': [1519], 'Among': [1520, 1669, 4331], 'them,': [1521, 1670, 4332], 'was': [1523, 1924, 2082, 2106, 2144, 2154, 2436, 2522, 2801, 2827, 2907, 2931, 2981, 3033, 3096, 3121, 3333, 3682, 3849, 3873, 3917, 4014, 4111, 4174, 4225, 4266, 4339], 'thyroid': [1526], '17,': [1527], 'ovarian': [1528], '18,': [1529], 'colon': [1531], 'cancers': [1532], '19,': [1533], '20,': [1534], 'promoted': [1537, 1871, 3370, 3622], 'breast': [1541], '21': [1544], 'astrocytoma': [1546], '22.': [1548], 'expressions': [1550, 2639, 2663], 'were': [1553, 1970, 2041, 2317, 2333, 2418, 2478, 2776, 2951, 3010, 3046, 3271, 3512, 3885, 3893, 3943, 3966, 4072, 4143, 4151, 4189], 'observed': [1554, 2481, 3335, 4277], 'colon,': [1556], 'lung': [1557], 'adenocarcinoma,': [1558], 'urothelial': [1559], 'carcinoma,': [1561], 'oral': [1563], 'carcinomas,': [1564], 'implying': [1565, 3354, 3525], 'may': [1568, 1661, 3357], 'play': [1569, 1662, 3358, 4354], 'drug': [1573], 'resistance': [1574], 'oxidative': [1576, 2692], 'damage': [1577], 'during': [1578, 1937, 3163, 3362], '23.': [1581], 'Notably,': [1582], 'it': [1583], 'unclear': [1585], 'whether': [1586, 2544, 2690, 3620, 4312], 'affects': [1588], 'metastasis.': [1590, 1668, 1801, 1881, 1919, 1996], 'Nuclear': [1591], 'factor-kappaB': [1592], '(NF-κB),': [1593], 'initially': [1594], 'discovered': [1595], 'studied': [1597], 'major': [1600], 'transcription': [1601, 1734], 'factor': [1602], 'immune': [1604], 'inflammatory': [1606], 'functions,': [1607], 'contributes': [1608], 'control': [1611, 3888, 3950, 4075, 4131, 4146, 4197], 'proliferation': [1614, 2498, 2817, 2825, 3378, 3906, 3915], 'oncogenesis': [1616], '24.': [1617], 'Studies': [1618], 'indicate': [1619, 1697, 2343, 3733], 'activation': [1621, 1643, 1754, 1817], 'positively': [1625, 2750], 'chemoresistance': [1630], '25,': [1631], 'PSA': [1632], 'recurrence': [1633], '26,': [1634], '27,': [1635], 'spread': [1638], '28,': [1639], '29.': [1640], 'gene': [1644, 4323], 'signature': [1645], 'effectively': [1646], 'predicted': [1647], 'metastasis-free': [1648], '30,': [1654], 'suggesting': [1655, 2728, 3605], 'genes': [1657, 1762, 1936, 2059], 'downstream': [1658, 4326], 'important': [1663, 1775], 'roles': [1664], 'interleukin': [1671], '(IL)-1β': [1672], 'prompted': [1673, 4263], 'grow': [1677], 'into': [1678, 1972, 2564, 2618, 2954], 'large': [1679], 'skeletal': [1680], 'lesions': [1681], 'mice': [1683, 1981, 2976], '31': [1684], 'mediate': [1687], 'cross-talk': [1688], 'between': [1689, 2070, 2502, 2765, 2819, 3307, 3327], 'osteoblasts': [1690], '32.': [1694], 'These': [1695], 'observations': [1696], 'potential': [1699, 1908, 1994, 2550, 2580, 3319, 3527], 'PC.': [1708, 3323], 'post-translational': [1710], 'modifications': [1711], 'determine': [1714, 2543, 4311], 'duration': [1716], 'strength': [1718], 'transcriptional': [1724, 1753, 1780], 'output': [1725], '33.': [1726], 'Recent': [1727], 'studies': [1728, 2139], 'revealed': [1729, 3275, 3303], 'TNF-α': [1731], 'stimulated': [1732], 'NF-κB,': [1749], 'several': [1760], 'anti-apoptotic': [1761], '34.': [1763, 4274], 'This': [1764], 'appears': [1771], 'be': [1773], 'modulating': [1778], 'activities.': [1781], 'present': [1784], 'study,': [1785], 'investigated': [1787, 3381], 'derivative': [1794, 1905], 'product,': [1795, 2518], 'H2S,': [1796], 'Our': [1802, 2570, 3273, 3659], 'study': [1803, 1838, 1900, 4258], 'showed': [1804, 1839, 3661], 'level,': [1813], 'NF-κB-mediated': [1819], 'instigate': [1823], 'subunit.': [1834], 'knockdown': [1841, 3479, 3490, 3799, 3824, 4347], 'resulted': [1847, 3400, 3547, 3590], 'lower': [1856, 2393, 3341], 'incidence': [1857, 1877], 'Moreover,': [1882], 'patients.': [1896], 'Overall,': [1897, 3730], 'current': [1899], 'identified': [1901], 'modalities': [1910], 'intervention': [1913], 'Results': [1920], 'Expression': [1921, 2741], 'To': [1930, 2057, 2114, 2454, 3157, 3238, 3438, 3617, 4310], 'elucidate': [1931], 'differential': [1933], 'established': [1941, 1948, 2043], 'paired': [1942, 2035, 2072], 'PC3-derived': [1943], 'lines': [1945, 2040, 2133, 2161, 2252, 2507, 2546, 3577], 'isolated': [1946, 2002], 'marrow': [1954, 2212, 2615], 'tumors,': [1958, 2049, 2622], 'respectively,': [1959, 2050], 'model': [1965], '35.': [1966], 'Briefly,': [1967], 'injected': [1971, 2953], 'ventral': [1974], 'portion': [1975], 'nude': [1980, 2055, 2568], 'allowed': [1983], '40': [1984], 'days': [1985], 'We': [1997, 2075, 2480, 2635, 3379, 4275], 'then': [1998, 3892, 3952, 4082, 4150, 4199], 'cultured': [1999], 'tumors': [2007, 3001, 3194, 3216, 3234], '"tumor-derived': [2010], 'cells"': [2012, 2030], 'or': [2013, 2031, 2409, 2468, 2474, 2620, 3114, 3232, 3794, 3819, 3889, 3936, 3947, 4079, 4135, 4147, 4194, 4284, 4291], 'T': [2014, 2039, 2232, 2506, 2552, 2766, 2771, 2820], 'lines,': [2015, 2553, 3541], 'well': [2017, 3203], 'thigh': [2022], 'marrows': [2024, 2046], 'obtain': [2026], '"bone-metastatic': [2028], 'B': [2032, 2037, 2235, 2504, 2545, 2768, 2773, 2822], 'lines.': [2033, 2074, 2255, 2299, 2699, 2769, 2823, 2884], 'Seven': [2034], 'thus': [2042], 'seven': [2052, 2087, 2204, 2248], 'tumor-bearing': [2054], 'mice.': [2056, 2569], 'identify': [2058, 3751], 'compared': [2067, 2215, 2530, 2718, 3226, 3285, 3691, 4288], 'profiles': [2069], 'found': [2076, 3642], 'enzyme,': [2078], 'five': [2085, 2271], 'pairs': [2088, 2105, 2205, 2249, 2464], 'microarray': [2094], 'analysis': [2095, 2111, 2198, 2243, 2259, 2286, 2399, 2806, 2846, 2936, 2986, 3004, 3101, 3108, 3274, 3294, 3781, 3878, 3925, 4019, 4119, 4179], '(Fig': [2096, 2112, 2134, 2493, 2508, 2536, 2586, 2675, 2724, 3208, 3290, 3314, 3350, 3420, 3436, 3482, 3505, 3521, 3557, 3603, 3676, 3699, 4308, 4348], 'EV1A),': [2097], 'among': [2103, 3573], 'validated': [2107], 'Western': [2109, 2241, 2257, 2284, 2844, 3779, 3923, 4117], 'blot': [2110, 2242, 2258, 2285, 2845, 3780, 3924, 4118], 'EV1B).': [2113], 'explore': [2115, 2455, 3239], 'biological': [2117, 2377, 2797, 2841, 2922, 3864, 4010, 4102, 4170, 4216], 'PC,': [2122, 2462], 'examined': [2124, 2637], 'EV1C).': [2135], 'Consistent': [2136, 3484], 'previous': [2138, 4257], '36,': [2140], 'level': [2143, 2179, 2903, 3785, 3845], 'absent': [2145], 'epithelial': [2149, 2266], 'line,': [2151], 'RWPE-1,': [2152, 2268], 'but': [2153, 2495, 3376, 3596], 'detectable': [2155], 'all': [2157], 'other': [2158, 2193, 2642, 3538], 'tested,': [2162], 'LNCaP,': [2164, 2276], 'C4-2,': [2165, 2277, 3545], 'PC3,': [2166, 2278], '22Rv1,': [2167], 'DU-145.': [2169], 'Click': [2170, 4047], 'here': [2171, 4048], 'expand': [2173, 4050], 'figure.': [2175, 2449, 3134, 4036, 4052, 4240], 'Figure': [2176, 2739, 3138, 3769, 4040, 4053], 'EV1.': [2177], 'A.': [2196, 2758, 3778], 'Microarray': [2197], 'showing': [2199], 'mRNA': [2201, 3063], 'grown': [2209, 2218], '(B': [2213], 'line),': [2214], '(T': [2225], 'line).': [2226], 'fold': [2228], 'changes': [2229], 'indicated': [2230, 2572], 'each': [2231], 'line': [2233, 2236, 2774], 'expression.': [2239, 2412, 3117], 'B.': [2240, 2813, 3802, 4067], 'PC3-B': [2251, 2698], 'PC3-T': [2254], 'C.': [2256, 2843, 3882, 4116], 'normal': [2265, 3071, 3268, 3288], 'together': [2269], '22RV1,': [2279], 'D.': [2283, 2870, 3904], 'CBS,': [2289], 'PC3-T2,': [2294, 2879, 2945], 'PC3-B2,': [2295, 2556, 2880, 2946], 'PC3-T3,': [2296, 2881, 2947], 'PC3-B3': [2298, 2527, 2576, 2597, 2653, 2673, 2715, 2883, 2949, 3465, 4070, 4127, 4285, 4301], 'E,': [2300, 2940], 'F.': [2301, 2941, 3940, 4186], 'Total': [2302], 'glutathione': [2303, 2311, 2314, 2345, 2684, 2706], '(GSH)': [2304, 2685], 'content': [2305, 2351, 2364], 'ratio': [2308, 2355, 2709], 'reduced': [2310, 3415, 3473, 3594, 3683, 4303], 'oxidized': [2313], '(GSH/GSSG).': [2315], 'Cells': [2316], 'seeded': [2318], 'at': [2319], 'density': [2321], '5': [2323], '×': [2324, 2943], '103': [2325], 'per': [2327, 2977], '96-well': [2328], 'plate': [2329], 'overnight;': [2330], 'then,': [2331], 'lysed': [2334], 'measure': [2336], 'GSH': [2338, 2357, 2695, 2702], 'GSSG': [2340, 2359], 'levels.': [2341], 'Data': [2342, 2366, 2787, 2832, 3073, 3136, 3993, 4000, 4038, 4091, 4160, 4206], 'total': [2344, 2349, 2362, 2701, 3262], 'normalized': [2347, 2360, 2370, 4095], '(E)': [2352, 2966, 4158], '(F).': [2365], 'shown': [2367, 2788, 2972, 4001, 4092, 4161, 4207], 'represent': [2368, 2789, 2914, 3856, 4002, 4093, 4162, 4208], 'means': [2371, 2791, 2835, 2916, 3077, 3858, 4004, 4096, 4164, 4210], '±': [2372, 2792, 2836, 2917, 3078, 3859, 4005, 4097, 4165, 4211], 'SD': [2373, 2793, 2837, 2918, 3079, 3860, 4006, 4098, 4166, 4212], '(n': [2374, 2794, 2838, 2919, 2973, 3080, 3861, 4007, 4099, 4167, 4213], '=': [2375, 2795, 2839, 2920, 2974, 3081, 3862, 4008, 4100, 4168, 4214], '3': [2376, 2796, 2840, 2921, 3863, 4009, 4101, 4169, 4215], 'replicates).': [2378, 2798, 2842, 2923, 3865, 4011, 4103, 4171, 4217], 'G,': [2379], 'H.': [2380], 'Association': [2381], 'pancreatic': [2389, 3337], 'adenocarcinoma': [2390, 3338], '(PAAD)': [2391, 3339], 'grade': [2394, 3342], 'glioma': [2395, 3343], '(LGG).': [2396], 'Kaplan–Meier': [2397, 3106], 'PAAD': [2401], '(G)': [2402], 'LGG': [2404], '(H)': [2405, 3061], 'high': [2408, 3113, 3308], 'low': [2410, 3115, 3633], 'downloaded': [2419, 3047], 'TCGA': [2422, 3050, 3257, 3347], 'database': [2423, 3051], 'described': [2425, 3053], 'section': [2428, 3056], 'Materials': [2430, 3058], 'Methods.': [2432, 3060], 'statistical': [2434, 2805, 2935, 2985, 3031, 3100, 3119, 3877, 4018, 4178], 'significance': [2435, 3032, 3120, 3242], 'determined': [2437, 3034, 3122], 'chi-square': [2440, 3037, 3125], 'test.': [2441, 3126], 'available': [2445, 3130, 4032, 4236], 'online': [2446, 3131, 4033, 4237], 'Download': [2450, 2452, 3141, 3143, 4043, 4045, 4241, 4243], 'figure': [2451, 3142, 4044, 4242], 'PowerPoint': [2453, 3144, 4046, 4244], 'functional': [2457], 'relevance': [2458], '(PC3-B2': [2467], 'PC3-B3)': [2469], 'versus': [2470, 3500], '(PC3-T2': [2473], 'PC3-T3)': [2475], 'selected.': [2479], 'exhibited': [2486, 2547, 2577], 'substantially': [2487, 3279], 'migration': [2489, 2761, 2779, 3373, 3430, 3459, 3475, 3508, 3554, 3568, 3602, 3624, 3672, 3739, 3896, 3955, 3978, 4059, 4085, 4154, 4202], 'abilities': [2492, 2764, 3511], '1A),': [2494], 'rate': [2499, 2818], 'remained': [2500, 2668, 2710], 'similar': [2501, 2669], '1B).': [2509], 'enzymatic': [2516, 3634, 3706], 'PC3-B2': [2525, 2574, 2595, 2651, 2671, 2713, 3413, 3434, 3463, 3498, 3795, 3820, 3883, 3909, 4068, 4125, 4283], 'PC3-T2': [2532, 2559, 2582, 2624, 2720, 3398, 3503, 3787, 3812, 4290], 'PC3-T3': [2534, 2561, 2584, 2626, 2722, 4292], '1C': [2537], 'D).': [2539], 'More': [2540, 3292], 'importantly,': [2541, 3293], 're-inoculated': [2555], 'PC3-B3,': [2557], 'orthotopically': [2563, 2853, 2952], 'prostates': [2566], '1E': [2587], 'F,': [2589, 3997], 'Appendix': [2590], 'Fig': [2591, 3236, 3486], 'S1),': [2592], 'indicating': [2593, 3316, 3561], 'gained': [2599], 'migratory': [2601], 'ability': [2602, 2631, 3723], 'disseminate': [2604], 'organs': [2607], 'such': [2608], 'paraaortic': [2610, 2962], 'nodes': [2612, 2964], 'grew': [2617], 'micro-': [2619], 'macrometastatic': [2621], 'whereas': [2623, 3406], 'had': [2628, 3597], 'much': [2629], 'less': [2630], 'do': [2633], 'so.': [2634], 'producing': [2645], 'enzymes,': [2646], '3MST,': [2649], 'contrast': [2656], 'EV1D).': [2676], 'Since': [2677], 'key': [2681], 'biosynthesis,': [2686], 'checked': [2689], 'stress': [2693], 'Both': [2700, 3507], 'disulfide': [2707], '(GSSG)/GSH': [2708], 'unchanged': [2711], 'EV1E': [2725], 'F),': [2727, 3524], 'redox': [2730], 'homeostasis': [2731], 'not': [2733, 3377, 3492, 3711], 'affected': [2734], '1.': [2740], 'increases': [2744], 'Comparison': [2759, 2814], 'incubated': [2777, 3953, 3976, 4083, 4200], '(16': [2780, 3897, 3956, 3979], 'h)': [2781, 2785, 3898, 3902, 3957, 3980, 3985], '(24': [2784, 3901, 3961, 3984], 'assay.': [2786, 4205], "Student's": [2799, 2979, 3094, 4012, 4172], 't-test': [2800, 2980, 3095, 4013, 4173], 'used': [2802, 2932, 2982, 3097, 3874, 4015, 4112, 4175, 4226], '(*P': [2807, 2937, 2987, 3879, 4020, 4180], '<': [2808, 2811, 2938, 2988, 2991, 3103, 3880, 4021, 4024, 4027, 4114, 4181, 4184, 4228, 4231], '0.05;': [2809, 2989, 4022, 4182], '**P': [2810, 2990, 4023], '0.01).': [2812, 2992, 3104], 'Cell': [2824, 3905, 3914], 'assay': [2826, 3916, 3960, 3983, 4089], 'performed': [2828, 3918], 'MTS': [2830, 3920], 'reagents.': [2831], '(T2': [2857], 'T3': [2859], 'lines)': [2860], 'metastasis-derived': [2863], '(B2': [2866], 'B3': [2868], 'lines).': [2869], 'Top:': [2871, 2994, 3803], 'catalyzing': [2873], 'lysates': [2877, 3810], 'Lead': [2885, 3827], 'acetate-soaked': [2886, 3828], 'paper': [2887, 3829], 'strips': [2888, 3830], 'show': [2889, 3831], 'PbS': [2891, 3833], 'brown': [2892, 3834], 'stain': [2893, 3835], 'result': [2896, 3838], 'H2S.': [2900, 3842], 'Bottom:': [2901, 3029, 3843], 'quantified': [2908, 3850], 'densitometry,': [2910, 3852], 'histograms': [2913, 3855], 'ANOVA': [2924, 3866, 4104, 4218], 'followed': [2925, 3867, 4105, 4219], "Tukey's": [2927, 3869, 4107, 4221], 'post': [2928, 3870, 4108, 4222], 'hoc': [2929, 3871, 4109, 4223], 'test': [2930, 3038, 3872, 4110, 4224], '0.05).': [2939, 3881], '106': [2944], '15–20': [2958], 'days.': [2959], 'Incidences': [2960], '(F)': [2970], '6–8': [2975], 'group).': [2978], 'G.': [2993, 3963], 'immunocytochemistry': [3003], 'commercial': [3006], 'tissue': [3007, 3231, 3269], 'arrays.': [3008], 'Samples': [3009], 'sub-grouped': [3011], 'TNM': [3013, 3183], 'stages.': [3014], 'representative': [3016], 'images': [3017], 'stages': [3020, 3175, 3223], 'shown.': [3022], 'S:': [3023], 'stroma;': [3024], 'Scale': [3025], 'bars:': [3026], '250': [3027], 'μm.': [3028], 'H,': [3039], 'I.': [3040], 'specimens': [3069, 3172, 3270], 'tissues.': [3072], 'presented': [3075], '50': [3082, 3267], 'cases': [3083, 3090], 'adjacent': [3085, 3197, 3229], 'non-tumor': [3086, 3230], 'parts': [3087], '469': [3089, 3264], 'tumors).': [3093], '(**P': [3102, 4227], '(I)': [3105], '[embr201845986-sup-0003-SDataFig1.pdf]': [3140], 'examine': [3158], 'evaluated': [3167], 'defined': [3174], 'grades': [3177], 'immunohistochemistry': [3179], 'staging': [3184], 'system': [3185], 'grouping.': [3187], 'evaluations': [3189], 'included': [3190], '105': [3191], '11': [3196], 'non-tumors.': [3198], 'staining': [3200], 'intensities': [3201], 'stage': [3207], '1G).': [3209, 3237], 'considerably': [3218, 3593], 'advanced': [3222], '(III/IV),': [3224], 'early-stage': [3233], '(I/II;': [3235], 'clinical': [3241], 'analyzed': [3246], 'correlation': [3248, 3306], 'overall': [3253], 'A': [3261], 'included.': [3272], 'tissues,': [3283], 'tissues': [3289], '1H).': [3291], '8': [3299], 'years': [3300], 'follow-up': [3302], 'significant': [3305], '1I),': [3315], 'prognostic': [3318], 'Concordantly,': [3324], 'association': [3326], '(LGG)': [3344], 'datasets': [3349], 'EV1G': [3351], 'H),': [3353], 'crucial': [3360], 'types.': [3368], 'invasion,': [3375], 'next': [3380], 'progression.': [3388], 'Overexpression': [3389], 'pCMV-CTH-HA': [3394, 3793, 3818], 'plasmid': [3396], 'production,': [3405, 3774], 'depletion': [3407, 3449, 4295], 'siRNA': [3411, 4299], '2A': [3421], 'B).': [3423], 'significantly': [3427, 3456, 3513, 4340], 'suppressed': [3428, 3457, 4248], '2C).': [3437], 'ensure': [3439], 'specificity': [3441], 'siRNA,': [3444, 4076, 4132], 'confirmed': [3447], 'siRNAs': [3455], 're-expression': [3468], 'successfully': [3471], 'rescued': [3472], 'upon': [3478], 'EV2A–C).': [3483], '1B,': [3487], 'did': [3491], 'affect': [3493], 'rates': [3496, 3907], 'those': [3501], '2D).': [3506], 'overexpressing': [3519], '2E': [3522], 'migration/invasion.': [3533], '22Rv1': [3543, 4139], 'both': [3552], 'EV2D': [3558], 'E),': [3560], 'tested.': [3578], 'Treatment': [3579], 'DL-propargylglycine': [3581], '(PAG),': [3582], 'irreversible': [3584], 'inhibitor': [3585], 'activity,': [3589], 'no': [3598], 'effect': [3599], '2G),': [3604], 'only': [3613], 'confirm': [3619], 'activity-independent,': [3627], 'mutant': [3631, 3668, 3757], 'activity.': [3635], 'Several': [3636], 'polymorphic': [3637], 'mutations': [3638], 'cystathioninuria,': [3646], 'mutation': [3648], 'Q240E': [3650, 3716], 'exhibits': [3651], '~70-fold': [3652], 'decrease': [3653], 'kinetic': [3656], '37.': [3658], 'CTHQ240E': [3667, 3688, 3756], 'still': [3669], 'induced': [3670], 'EV2F).': [3677, 3700], 'However,': [3678], 'expressing': [3686, 3695, 3727], 'mutant,': [3689, 3717], 'wild': [3697], 'type': [3698], 'Due': [3701], 'fact': [3704], 'completely': [3712], 'abolished': [3713], 'there': [3718], 'existed': [3719], 'residual': [3720], 'mutant.': [3729], 'enzyme-independent': [3742], 'pathway.': [3743], 'future,': [3746], 'will': [3748], 'try': [3749], 'interacting': [3753], 'decipher': [3759], 'unknown': [3761], 'how': [3764], 'migration.': [3768], 'migration,': [3775], 'siCTH-1.': [3801, 3826], 'capacity': [3807], 'transfected': [3886, 3933, 3944, 4073, 4129, 4144, 4190], 'siCTH-1': [3890, 4148], 'subjected': [3894, 4152], 'assays.': [3903, 4159], 'knockdown.': [3913], 'reagent.': [3921], 'E.': [3922, 4138], 'HA-CTH': [3935, 3946], 'pCMV-HA': [3937, 3948, 4195], 'vector': [3938, 3949, 4196], 'control.': [3939], 'h).': [3962], 'pre-treated': [3967], '10': [3969, 3990], 'μM': [3970, 3991], 'PAG': [3971], '16': [3973], 'h,': [3974], 'presence': [3988], 'PAG.': [3992], 'information:': [3994], '(C,': [3995], 'D,': [3996, 4137], 'G)': [3999], '0.01;': [4025, 4229], '***P': [4026, 4183, 4230], '0.001).': [4028, 4115, 4185, 4232], '2': [4041], '[embr201845986-sup-0004-SDataFig2.pdf]': [4042], 'EV2.': [4054], 'stimulates': [4057], 'A,': [4066], 'siCTH-1,': [4077, 4133], '2,': [4078, 4134], 'pCMV-CTH-HA,': [4080], '(A)': [4086], '(B).': [4090], '(***P': [4113], 'pCMV-CTH-HA.': [4136], 'C4-2': [4141], '(D)': [4155], 'HA-CTH,': [4192], 'HA-CTHQ240E,': [4193], 'inhibition': [4252], 'NF-κΒ-IL-1β-mediated': [4254], 'demonstrated': [4259], 'NF-κΒ': [4265, 4313], 'EV3A).': [4309], 'assessed': [4321], 'profile': [4325], 'NF-κΒ-mediated': [4329, 4360], 'IL-1β,': [4333], 'one': [4334], 'pro-inflammatory': [4337], 'cytokines,': [4338], 'inhibited': [4341], '3A).': [4349], 'positive': [4356], 'autoregulatory': [4357], 'loop': [4358], '38.': [4362], 'adding': [4364], 'human': [4365], 'recombinant': [4366], 'culture': [4370], 'mediu': [4371]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2971008999', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 22}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 3}], 'updated_date': '2024-12-23T22:39:26.477196', 'created_date': '2019-09-05'}
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