Title: Stereoselective Catalytic Synthesis of<i>P</i>-Stereogenic Oxides via Hydrogenative Kinetic Resolution
Abstract:A highly stereoselective catalytic method for the preparation of structurally diverse P-stereogenic oxides has been developed. The approach relies on the ability of rhodium complexes derived from an e...A highly stereoselective catalytic method for the preparation of structurally diverse P-stereogenic oxides has been developed. The approach relies on the ability of rhodium complexes derived from an enantiopure P-OP ligand to kinetically resolve racemic α,β-unsaturated phosphane oxides by hydrogenation of the C═C motif and formation of highly enantioenriched (or even enantiopure) P-stereogenic oxides. The practicality of the methodology has been demonstrated by the preparation of potentially functional P-chiral molecules for catalytic enantioselective synthesis.Read More
Publication Year: 2019
Publication Date: 2019-08-28
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 26
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