Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2969531372', 'doi': 'https://doi.org/10.3390/md17090493', 'title': 'A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors', 'display_name': 'A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors', 'publication_year': 2019, 'publication_date': '2019-08-23', 'ids': {'openalex': 'https://openalex.org/W2969531372', 'doi': 'https://doi.org/10.3390/md17090493', 'mag': '2969531372', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31450856', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6780990'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/md17090493', 'pdf_url': 'https://www.mdpi.com/1660-3397/17/9/493/pdf?version=1567078716', 'source': {'id': 'https://openalex.org/S146563757', 'display_name': 'Marine Drugs', 'issn_l': '1660-3397', 'issn': ['1660-3397'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1660-3397/17/9/493/pdf?version=1567078716', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100679284', 'display_name': 'Te Li', 'orcid': 'https://orcid.org/0000-0002-9007-469X'}, 'institutions': [{'id': 'https://openalex.org/I109935558', 'display_name': 'Ningbo University', 'ror': 'https://ror.org/03et85d35', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I109935558']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Te Li', 'raw_affiliation_strings': ['Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China'], 'affiliations': [{'raw_affiliation_string': 'Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China', 'institution_ids': ['https://openalex.org/I109935558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100387156', 'display_name': 'Ning Wang', 'orcid': 'https://orcid.org/0000-0002-5625-5358'}, 'institutions': [{'id': 'https://openalex.org/I109935558', 'display_name': 'Ningbo University', 'ror': 'https://ror.org/03et85d35', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I109935558']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ning Wang', 'raw_affiliation_strings': ['Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, Zhejiang, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, Zhejiang, China', 'institution_ids': ['https://openalex.org/I109935558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100458280', 'display_name': 'Ting Zhang', 'orcid': 'https://orcid.org/0000-0001-6911-6333'}, 'institutions': [{'id': 'https://openalex.org/I109935558', 'display_name': 'Ningbo University', 'ror': 'https://ror.org/03et85d35', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I109935558']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ting Zhang', 'raw_affiliation_strings': ['Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China'], 'affiliations': [{'raw_affiliation_string': 'Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China', 'institution_ids': ['https://openalex.org/I109935558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100392839', 'display_name': 'Bin Zhang', 'orcid': 'https://orcid.org/0000-0002-4371-4746'}, 'institutions': [{'id': 'https://openalex.org/I109935558', 'display_name': 'Ningbo University', 'ror': 'https://ror.org/03et85d35', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I109935558']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Bin Zhang', 'raw_affiliation_strings': ['Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China'], 'affiliations': [{'raw_affiliation_string': 'Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China', 'institution_ids': ['https://openalex.org/I109935558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008831408', 'display_name': 'Sajeevan Thavarool Puthiyedathu', 'orcid': 'https://orcid.org/0000-0001-6183-6731'}, 'institutions': [{'id': 'https://openalex.org/I20497027', 'display_name': 'Cochin University of Science and Technology', 'ror': 'https://ror.org/00a4kqq17', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I20497027']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Thavarool P. Sajeevan', 'raw_affiliation_strings': ['National Centre for Aquatic Animal Health, Cochin University of Science and Technology, Fine Arts Avenue, Kochi, Kerala 682016, India'], 'affiliations': [{'raw_affiliation_string': 'National Centre for Aquatic Animal Health, Cochin University of Science and Technology, Fine Arts Avenue, Kochi, Kerala 682016, India', 'institution_ids': ['https://openalex.org/I20497027']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018785566', 'display_name': 'Valsamma Joseph', 'orcid': 'https://orcid.org/0000-0002-3080-710X'}, 'institutions': [{'id': 'https://openalex.org/I20497027', 'display_name': 'Cochin University of Science and Technology', 'ror': 'https://ror.org/00a4kqq17', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I20497027']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Valsamma Joseph', 'raw_affiliation_strings': ['National Centre for Aquatic Animal Health, Cochin University of Science and Technology, Fine Arts Avenue, Kochi, Kerala 682016, India'], 'affiliations': [{'raw_affiliation_string': 'National Centre for Aquatic Animal Health, Cochin University of Science and Technology, Fine Arts Avenue, Kochi, Kerala 682016, India', 'institution_ids': ['https://openalex.org/I20497027']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038229556', 'display_name': 'Lorene Armstrong', 'orcid': 'https://orcid.org/0000-0003-4078-8990'}, 'institutions': [{'id': 'https://openalex.org/I68207295', 'display_name': 'Universidade Estadual de Ponta Grossa', 'ror': 'https://ror.org/027s08w94', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I68207295']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Lorene Armstrong', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, ParanĂ¡ 84030900, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, ParanĂ¡ 84030900, Brazil', 'institution_ids': ['https://openalex.org/I68207295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071666503', 'display_name': 'Shan He', 'orcid': 'https://orcid.org/0000-0002-0196-7278'}, 'institutions': [{'id': 'https://openalex.org/I109935558', 'display_name': 'Ningbo University', 'ror': 'https://ror.org/03et85d35', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I109935558']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shan He', 'raw_affiliation_strings': ['Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China'], 'affiliations': [{'raw_affiliation_string': 'Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China', 'institution_ids': ['https://openalex.org/I109935558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022586564', 'display_name': 'Xiaojun Yan', 'orcid': 'https://orcid.org/0000-0003-0257-0157'}, 'institutions': [{'id': 'https://openalex.org/I109935558', 'display_name': 'Ningbo University', 'ror': 'https://ror.org/03et85d35', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I109935558']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaojun Yan', 'raw_affiliation_strings': ['Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China'], 'affiliations': [{'raw_affiliation_string': 'Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China', 'institution_ids': ['https://openalex.org/I109935558']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049804114', 'display_name': 'C. Benjamin Naman', 'orcid': 'https://orcid.org/0000-0002-4361-506X'}, 'institutions': [{'id': 'https://openalex.org/I109935558', 'display_name': 'Ningbo University', 'ror': 'https://ror.org/03et85d35', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I109935558']}, {'id': 'https://openalex.org/I150209017', 'display_name': 'Scripps Institution of Oceanography', 'ror': 'https://ror.org/04v7hvq31', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I150209017', 'https://openalex.org/I36258959']}, {'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['CN', 'US'], 'is_corresponding': True, 'raw_author_name': 'C. Benjamin Naman', 'raw_affiliation_strings': ['Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA', 'Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China'], 'affiliations': [{'raw_affiliation_string': 'Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China', 'institution_ids': ['https://openalex.org/I109935558']}, {'raw_affiliation_string': 'Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA', 'institution_ids': ['https://openalex.org/I150209017', 'https://openalex.org/I36258959']}]}], 'countries_distinct_count': 4, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5100392839', 'https://openalex.org/A5049804114'], 'corresponding_institution_ids': ['https://openalex.org/I109935558', 'https://openalex.org/I109935558', 'https://openalex.org/I150209017', 'https://openalex.org/I36258959'], 'apc_list': {'value': 2500, 'currency': 'CHF', 'value_usd': 2707, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'CHF', 'value_usd': 2707, 'provenance': 'doaj'}, 'fwci': 1.096, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 39, 'citation_normalized_percentile': {'value': 0.998562, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '17', 'issue': '9', 'first_page': '493', 'last_page': '493'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10252', 'display_name': 'Natural Products as Sources of New Drugs', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10252', 'display_name': 'Natural Products as Sources of New Drugs', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11340', 'display_name': 'Sponge-Associated Microorganisms and Biotechnological Potential', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12412', 'display_name': 'Role of Carbonic Anhydrases in Medicine and Biotechnology', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/natural-product', 'display_name': 'Natural product', 'score': 0.8354541}, {'id': 'https://openalex.org/keywords/marine-natural-products', 'display_name': 'Marine Natural Products', 'score': 0.522294}], 'concepts': [{'id': 'https://openalex.org/C2779396153', 'wikidata': 'https://www.wikidata.org/wiki/Q901227', 'display_name': 'Natural product', 'level': 2, 'score': 0.8354541}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.57587385}, {'id': 'https://openalex.org/C56173144', 'wikidata': 'https://www.wikidata.org/wiki/Q1539893', 'display_name': 'Pharmacophore', 'level': 2, 'score': 0.5426692}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5402801}, {'id': 'https://openalex.org/C74187038', 'wikidata': 'https://www.wikidata.org/wiki/Q1418791', 'display_name': 'Drug discovery', 'level': 2, 'score': 0.47820973}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.4498887}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32687777}], 'mesh': [{'descriptor_ui': 'D059001', 'descriptor_name': 'Aquatic Organisms', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059001', 'descriptor_name': 'Aquatic Organisms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001424', 'descriptor_name': 'Bacterial Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001424', 'descriptor_name': 'Bacterial Infections', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/md17090493', 'pdf_url': 'https://www.mdpi.com/1660-3397/17/9/493/pdf?version=1567078716', 'source': {'id': 'https://openalex.org/S146563757', 'display_name': 'Marine Drugs', 'issn_l': '1660-3397', 'issn': ['1660-3397'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/bb67ba5fb8694c7090719cb0d8e182a4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6780990', 'pdf_url': 'https://europepmc.org/articles/pmc6780990?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780990', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31450856', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/md17090493', 'pdf_url': 'https://www.mdpi.com/1660-3397/17/9/493/pdf?version=1567078716', 'source': {'id': 'https://openalex.org/S146563757', 'display_name': 'Marine Drugs', 'issn_l': '1660-3397', 'issn': ['1660-3397'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.86, 'display_name': 'Life below water', 'id': 'https://metadata.un.org/sdg/14'}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '41776168'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81850410553'}, {'funder': 'https://openalex.org/F4320321540', 'funder_display_name': "Ministry of Science and Technology of the People's Republic of China", 'award_id': '2018YFC0310900'}, {'funder': 'https://openalex.org/F4320322605', 'funder_display_name': 'Ningbo University', 'award_id': 'XYL18004'}, {'funder': 'https://openalex.org/F4320327912', 'funder_display_name': 'Higher Education Discipline Innovation Project', 'award_id': 'D16013'}, {'funder': 'https://openalex.org/F4320332587', 'funder_display_name': 'Natural Science Foundation of Ningbo', 'award_id': '2018A610410'}], 'datasets': [], 'versions': [], 'referenced_works_count': 137, 'referenced_works': ['https://openalex.org/W1143285126', 'https://openalex.org/W1481287627', 'https://openalex.org/W1543963511', 'https://openalex.org/W1558255813', 'https://openalex.org/W1572448310', 'https://openalex.org/W1763611224', 'https://openalex.org/W1868808160', 'https://openalex.org/W1967136578', 'https://openalex.org/W1971910884', 'https://openalex.org/W1976045837', 'https://openalex.org/W1976867517', 'https://openalex.org/W1982803778', 'https://openalex.org/W1988112668', 'https://openalex.org/W1989221709', 'https://openalex.org/W1990365889', 'https://openalex.org/W1992084711', 'https://openalex.org/W1992716708', 'https://openalex.org/W1994498168', 'https://openalex.org/W2000052188', 'https://openalex.org/W2000871736', 'https://openalex.org/W2001097406', 'https://openalex.org/W2011002865', 'https://openalex.org/W2013003830', 'https://openalex.org/W2014931025', 'https://openalex.org/W2019095372', 'https://openalex.org/W2020732748', 'https://openalex.org/W2021255160', 'https://openalex.org/W2026023613', 'https://openalex.org/W2027614355', 'https://openalex.org/W2027656346', 'https://openalex.org/W2031272644', 'https://openalex.org/W2031930009', 'https://openalex.org/W2031982459', 'https://openalex.org/W2034717034', 'https://openalex.org/W2039002745', 'https://openalex.org/W2039190911', 'https://openalex.org/W2040238921', 'https://openalex.org/W2043794217', 'https://openalex.org/W2048244314', 'https://openalex.org/W2048828296', 'https://openalex.org/W2049048182', 'https://openalex.org/W2049110814', 'https://openalex.org/W2051522187', 'https://openalex.org/W2057117299', 'https://openalex.org/W2057682146', 'https://openalex.org/W2058832210', 'https://openalex.org/W2061383088', 'https://openalex.org/W2061463182', 'https://openalex.org/W2062471223', 'https://openalex.org/W2063426813', 'https://openalex.org/W2072133690', 'https://openalex.org/W2078732389', 'https://openalex.org/W2079316190', 'https://openalex.org/W2079398727', 'https://openalex.org/W2085561094', 'https://openalex.org/W2086544714', 'https://openalex.org/W2090300080', 'https://openalex.org/W2096287391', 'https://openalex.org/W2105161867', 'https://openalex.org/W2107068319', 'https://openalex.org/W2108567906', 'https://openalex.org/W2109846728', 'https://openalex.org/W2110867444', 'https://openalex.org/W2111139603', 'https://openalex.org/W2118942065', 'https://openalex.org/W2124965176', 'https://openalex.org/W2125020940', 'https://openalex.org/W2126662293', 'https://openalex.org/W2127930924', 'https://openalex.org/W2131761965', 'https://openalex.org/W2133347001', 'https://openalex.org/W2138117878', 'https://openalex.org/W2145442626', 'https://openalex.org/W2148247091', 'https://openalex.org/W2150981403', 'https://openalex.org/W2159589245', 'https://openalex.org/W2163261356', 'https://openalex.org/W2172747923', 'https://openalex.org/W2200277569', 'https://openalex.org/W2249334986', 'https://openalex.org/W2309382792', 'https://openalex.org/W2329845116', 'https://openalex.org/W2333099412', 'https://openalex.org/W2333639487', 'https://openalex.org/W2336464568', 'https://openalex.org/W2412343702', 'https://openalex.org/W2415738162', 'https://openalex.org/W2493808618', 'https://openalex.org/W2517971081', 'https://openalex.org/W2530860835', 'https://openalex.org/W2543382862', 'https://openalex.org/W2547982875', 'https://openalex.org/W2548493717', 'https://openalex.org/W2553392785', 'https://openalex.org/W2556197352', 'https://openalex.org/W2560091007', 'https://openalex.org/W2560341035', 'https://openalex.org/W2568902477', 'https://openalex.org/W2569565111', 'https://openalex.org/W2579264422', 'https://openalex.org/W2586486297', 'https://openalex.org/W2592434857', 'https://openalex.org/W2604331022', 'https://openalex.org/W2604705290', 'https://openalex.org/W2605881606', 'https://openalex.org/W2611021352', 'https://openalex.org/W2736773712', 'https://openalex.org/W2742624084', 'https://openalex.org/W2754661614', 'https://openalex.org/W2765650219', 'https://openalex.org/W2766652229', 'https://openalex.org/W2770780905', 'https://openalex.org/W2776321482', 'https://openalex.org/W2778133983', 'https://openalex.org/W2787101215', 'https://openalex.org/W2790666976', 'https://openalex.org/W2792325880', 'https://openalex.org/W2793564579', 'https://openalex.org/W2793642852', 'https://openalex.org/W2794211762', 'https://openalex.org/W2795084185', 'https://openalex.org/W2797068781', 'https://openalex.org/W2802010452', 'https://openalex.org/W2804583760', 'https://openalex.org/W2883827837', 'https://openalex.org/W2884174891', 'https://openalex.org/W2884743525', 'https://openalex.org/W2886363386', 'https://openalex.org/W2886895844', 'https://openalex.org/W2889894321', 'https://openalex.org/W2891469948', 'https://openalex.org/W2903691289', 'https://openalex.org/W2950346356', 'https://openalex.org/W297380522', 'https://openalex.org/W4211024023', 'https://openalex.org/W74279752', 'https://openalex.org/W934980950'], 'related_works': ['https://openalex.org/W4367601179', 'https://openalex.org/W4327862425', 'https://openalex.org/W3201311513', 'https://openalex.org/W2904244272', 'https://openalex.org/W2885415938', 'https://openalex.org/W2770470780', 'https://openalex.org/W2584285938', 'https://openalex.org/W2338154590', 'https://openalex.org/W2297869962', 'https://openalex.org/W2127597456'], 'abstract_inverted_index': {'Protein': [0], 'kinases': [1], 'are': [2, 31, 121], 'validated': [3], 'drug': [4], 'targets': [5], 'for': [6, 71], 'a': [7], 'number': [8], 'of': [9, 84, 89], 'therapeutic': [10, 101], 'areas,': [11], 'as': [12, 48, 91], 'kinase': [13, 29, 65, 105], 'deregulation': [14], 'is': [15], 'known': [16], 'to': [17, 62, 104], 'play': [18], 'an': [19], 'essential': [20], 'role': [21], 'in': [22], 'many': [23], 'disease': [24], 'states.': [25], 'Many': [26, 39], 'investigated': [27], 'protein': [28], 'inhibitors': [30], 'natural': [32, 41, 118], 'product': [33, 119], 'small': [34], 'molecules': [35], 'or': [36, 68], 'their': [37], 'derivatives.': [38], 'marine-derived': [40, 117], 'products': [42], 'from': [43, 81, 95], 'various': [44], 'marine': [45, 96], 'sources,': [46], 'such': [47], 'bacteria': [49], 'and': [50, 98, 107], 'cyanobacteria,': [51], 'fungi,': [52], 'animals,': [53], 'algae,': [54], 'soft': [55], 'corals,': [56], 'sponges,': [57], 'etc.': [58], 'have': [59, 63], 'been': [60, 93], 'found': [61], 'potent': [64], 'inhibitory': [66, 106], 'activity,': [67], 'desirable': [69], 'pharmacophores': [70], 'further': [72], 'development.': [73], 'This': [74], 'review': [75], 'covers': [76], 'the': [77, 82, 87], 'new': [78], 'compounds': [79], 'reported': [80], 'beginning': [83], '2014': [85], 'through': [86], 'middle': [88], '2019': [90], 'having': [92, 99], 'isolated': [94], 'organisms': [97], 'potential': [100], 'applications': [102], 'due': [103], 'associated': [108], 'bioactivities.': [109], 'Moreover,': [110], 'some': [111], 'existing': [112], 'clinical': [113], 'drugs': [114], 'based': [115], 'on': [116], 'scaffolds': [120], 'also': [122], 'discussed.': [123]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2969531372', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-09-01T07:58:00.924618', 'created_date': '2019-08-29'}