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'complexity': [53], 'cost': [55], 'studies.': [58], 'We': [59, 201], 'developed': [60], 'a': [61, 98, 122, 161, 190], 'toolkit,': [62], '‘MetaSIPSim,’': [63], 'simulate': [65], 'sequencing': [66, 102, 134], 'read': [67], 'libraries': [68], 'for': [69, 78, 193, 214, 231], 'experiments.': [71], 'MetaSIPSim': [72, 88, 212], 'intended': [74], 'generate': [76], 'datasets': [77, 218], 'method': [79, 185, 192], 'testing.': [82], 'To': [83], 'this': [84], 'end,': [85], 'we': [86, 107], 'used': [87], 'generated': [89], 'data': [90], 'demonstrate': [92], 'advantages': [94], 'over': [97], 'conventional': [99, 123], 'shotgun': [100], 'metagenomic': [101, 124], 'experiment.': [103], 'Results': [104], 'Through': [105], 'simulation': [106, 215], 'show': [108, 202], 'that': [109, 203], 'isotopically': [117, 168, 195], 'labeled': [118, 144, 196], 'relative': [120], 'approach.': [125], 'Improvements': [126], 'were': [127], 'dependent': [128], 'on': [129, 133, 207], 'experimental': [130, 210], 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