Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2966937658', 'doi': 'https://doi.org/10.1038/s41467-019-11293-8', 'title': 'Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns', 'display_name': 'Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns', 'publication_year': 2019, 'publication_date': '2019-08-13', 'ids': {'openalex': 'https://openalex.org/W2966937658', 'doi': 'https://doi.org/10.1038/s41467-019-11293-8', 'mag': '2966937658', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31409787', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6692369'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-019-11293-8', 'pdf_url': 'https://www.nature.com/articles/s41467-019-11293-8.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41467-019-11293-8.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001241393', 'display_name': 'Sandra Keiper', 'orcid': 'https://orcid.org/0000-0002-2858-4955'}, 'institutions': [{'id': 'https://openalex.org/I4210131661', 'display_name': 'Max Planck Institute for Biophysical Chemistry', 'ror': 'https://ror.org/03e76ya46', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210131661']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Sandra Keiper', 'raw_affiliation_strings': ['Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany', 'institution_ids': ['https://openalex.org/I4210131661']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025149116', 'display_name': 'Panagiotis Papasaikas', 'orcid': 'https://orcid.org/0000-0002-1640-7636'}, 'institutions': [{'id': 'https://openalex.org/I170486558', 'display_name': 'Pompeu Fabra University', 'ror': 'https://ror.org/04n0g0b29', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I170486558']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Panagiotis Papasaikas', 'raw_affiliation_strings': ['Centre de Regulació Genòmica, The Barcelona Institute of Science and Technology and Universitat Pompeu Fabra, Dr. Aiguader 88, 08003, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Centre de Regulació Genòmica, The Barcelona Institute of Science and Technology and Universitat Pompeu Fabra, Dr. Aiguader 88, 08003, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I170486558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090325951', 'display_name': 'Cindy L. Will', 'orcid': 'https://orcid.org/0000-0003-0012-9106'}, 'institutions': [{'id': 'https://openalex.org/I4210131661', 'display_name': 'Max Planck Institute for Biophysical Chemistry', 'ror': 'https://ror.org/03e76ya46', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210131661']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Cindy L. Will', 'raw_affiliation_strings': ['Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany', 'institution_ids': ['https://openalex.org/I4210131661']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022884999', 'display_name': 'Juan Valcárcel', 'orcid': 'https://orcid.org/0000-0001-5398-3571'}, 'institutions': [{'id': 'https://openalex.org/I170486558', 'display_name': 'Pompeu Fabra University', 'ror': 'https://ror.org/04n0g0b29', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I170486558']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Juan Valcárcel', 'raw_affiliation_strings': ['Centre de Regulació Genòmica, The Barcelona Institute of Science and Technology and Universitat Pompeu Fabra, Dr. Aiguader 88, 08003, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Centre de Regulació Genòmica, The Barcelona Institute of Science and Technology and Universitat Pompeu Fabra, Dr. Aiguader 88, 08003, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I170486558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027006482', 'display_name': 'Cyrille Girard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210131661', 'display_name': 'Max Planck Institute for Biophysical Chemistry', 'ror': 'https://ror.org/03e76ya46', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210131661']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Cyrille Girard', 'raw_affiliation_strings': ['Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany', 'institution_ids': ['https://openalex.org/I4210131661']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024316359', 'display_name': 'Reinhard Lührmann', 'orcid': 'https://orcid.org/0000-0003-3253-7518'}, 'institutions': [{'id': 'https://openalex.org/I4210131661', 'display_name': 'Max Planck Institute for Biophysical Chemistry', 'ror': 'https://ror.org/03e76ya46', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210131661']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Reinhard Lührmann', 'raw_affiliation_strings': ['Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany', 'institution_ids': ['https://openalex.org/I4210131661']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'apc_paid': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'fwci': 1.534, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 31, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '10', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'Regulation of RNA Processing and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'Regulation of RNA Processing and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/spliceosome', 'display_name': 'Spliceosome', 'score': 0.9794694}, {'id': 'https://openalex.org/keywords/minor-spliceosome', 'display_name': 'Minor spliceosome', 'score': 0.70038533}, {'id': 'https://openalex.org/keywords/group-ii-intron', 'display_name': 'Group II intron', 'score': 0.5922917}, {'id': 'https://openalex.org/keywords/splicing-factor', 'display_name': 'Splicing factor', 'score': 0.57347894}, {'id': 'https://openalex.org/keywords/alternative-splicing', 'display_name': 'Alternative Splicing', 'score': 0.490465}, {'id': 'https://openalex.org/keywords/exonic-splicing-enhancer', 'display_name': 'Exonic splicing enhancer', 'score': 0.4547143}], 'concepts': [{'id': 'https://openalex.org/C40000846', 'wikidata': 'https://www.wikidata.org/wiki/Q915868', 'display_name': 'Spliceosome', 'level': 5, 'score': 0.9794694}, {'id': 'https://openalex.org/C54458228', 'wikidata': 'https://www.wikidata.org/wiki/Q237218', 'display_name': 'RNA splicing', 'level': 4, 'score': 0.92881083}, {'id': 'https://openalex.org/C94671646', 'wikidata': 'https://www.wikidata.org/wiki/Q207551', 'display_name': 'Intron', 'level': 3, 'score': 0.84631085}, {'id': 'https://openalex.org/C60542250', 'wikidata': 'https://www.wikidata.org/wiki/Q21105762', 'display_name': 'Minor spliceosome', 'level': 5, 'score': 0.70038533}, {'id': 'https://openalex.org/C64962909', 'wikidata': 'https://www.wikidata.org/wiki/Q5611160', 'display_name': 'Group II intron', 'level': 5, 'score': 0.5922917}, {'id': 'https://openalex.org/C73758832', 'wikidata': 'https://www.wikidata.org/wiki/Q7578564', 'display_name': 'Splicing factor', 'level': 5, 'score': 0.57347894}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.50947577}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4791043}, {'id': 'https://openalex.org/C194583182', 'wikidata': 'https://www.wikidata.org/wiki/Q21114084', 'display_name': 'Alternative splicing', 'level': 4, 'score': 0.4549621}, {'id': 'https://openalex.org/C42576000', 'wikidata': 'https://www.wikidata.org/wiki/Q5420618', 'display_name': 'Exonic splicing enhancer', 'level': 5, 'score': 0.4547143}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.4205587}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.41695568}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.40216076}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.29598054}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.2014305}], 'mesh': [{'descriptor_ui': 'D002868', 'descriptor_name': 'Chromosomal Proteins, Non-Histone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007438', 'descriptor_name': 'Introns', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012326', 'descriptor_name': 'RNA Splicing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017381', 'descriptor_name': 'Spliceosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002868', 'descriptor_name': 'Chromosomal Proteins, Non-Histone', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002868', 'descriptor_name': 'Chromosomal Proteins, Non-Histone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012322', 'descriptor_name': 'RNA Precursors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012322', 'descriptor_name': 'RNA Precursors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012322', 'descriptor_name': 'RNA Precursors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022821', 'descriptor_name': 'RNA Splice Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017381', 'descriptor_name': 'Spliceosomes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017381', 'descriptor_name': 'Spliceosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-019-11293-8', 'pdf_url': 'https://www.nature.com/articles/s41467-019-11293-8.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/4553e27de950463e8f18f5857d925e60', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6692369', 'pdf_url': 'https://europepmc.org/articles/pmc6692369?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10230/42531', 'pdf_url': 'http://repositori.upf.edu/bitstream/10230/42531/1/Keiper_nc_smu1.pdf', 'source': {'id': 'https://openalex.org/S4306402615', 'display_name': 'Repositori digital de la UPF (Universitat Pompeu Fabra)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I170486558', 'host_organization_name': 'Pompeu Fabra University', 'host_organization_lineage': ['https://openalex.org/I170486558'], 'host_organization_lineage_names': ['Pompeu Fabra University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/21.11116/0000-0004-7738-8', 'pdf_url': 'https://pure.mpg.de/pubman/item/item_3152573_2/component/file_3152574/3152573.pdf', 'source': {'id': 'https://openalex.org/S4306400655', 'display_name': 'MPG.PuRe (Max Planck Society)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I149899117', 'host_organization_name': 'Max Planck Society', 'host_organization_lineage': ['https://openalex.org/I149899117'], 'host_organization_lineage_names': ['Max Planck Society'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692369', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31409787', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-019-11293-8', 'pdf_url': 'https://www.nature.com/articles/s41467-019-11293-8.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320320879', 'funder_display_name': 'Deutsche Forschungsgemeinschaft', 'award_id': 'SFB 860'}], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W12952247', 'https://openalex.org/W1571106259', 'https://openalex.org/W1971641541', 'https://openalex.org/W1973697733', 'https://openalex.org/W1977658792', 'https://openalex.org/W1978520851', 'https://openalex.org/W1979693199', 'https://openalex.org/W1979731334', 'https://openalex.org/W1987607182', 'https://openalex.org/W1989109522', 'https://openalex.org/W1989482194', 'https://openalex.org/W1997403103', 'https://openalex.org/W2014517533', 'https://openalex.org/W2026815932', 'https://openalex.org/W2027130557', 'https://openalex.org/W2029425286', 'https://openalex.org/W2030060766', 'https://openalex.org/W2031197577', 'https://openalex.org/W2035300822', 'https://openalex.org/W2039440729', 'https://openalex.org/W2040527821', 'https://openalex.org/W2042606009', 'https://openalex.org/W2048575195', 'https://openalex.org/W2053984185', 'https://openalex.org/W2054183206', 'https://openalex.org/W2059022126', 'https://openalex.org/W2064455466', 'https://openalex.org/W2065188175', 'https://openalex.org/W2065455422', 'https://openalex.org/W2065505409', 'https://openalex.org/W2077594389', 'https://openalex.org/W2081132215', 'https://openalex.org/W2083531821', 'https://openalex.org/W2093131463', 'https://openalex.org/W2100305481', 'https://openalex.org/W2108132320', 'https://openalex.org/W2111023901', 'https://openalex.org/W2116568230', 'https://openalex.org/W2117483168', 'https://openalex.org/W2123123598', 'https://openalex.org/W2127843422', 'https://openalex.org/W2143350291', 'https://openalex.org/W2148393113', 'https://openalex.org/W2157594180', 'https://openalex.org/W2160683304', 'https://openalex.org/W2168915479', 'https://openalex.org/W2172189627', 'https://openalex.org/W2282402804', 'https://openalex.org/W2335845339', 'https://openalex.org/W2414820077', 'https://openalex.org/W2544234056', 'https://openalex.org/W2604253948', 'https://openalex.org/W2614767307', 'https://openalex.org/W2744206279', 'https://openalex.org/W2784237640', 'https://openalex.org/W2790997724', 'https://openalex.org/W2799994822', 'https://openalex.org/W4256563997'], 'related_works': ['https://openalex.org/W3175943595', 'https://openalex.org/W2973719278', 'https://openalex.org/W2134366891', 'https://openalex.org/W2120914446', 'https://openalex.org/W2066876408', 'https://openalex.org/W2027447954', 'https://openalex.org/W2025675806', 'https://openalex.org/W1983986427', 'https://openalex.org/W126313008', 'https://openalex.org/W101916417'], 'abstract_inverted_index': {'Abstract': [0], 'Human': [1], 'pre-catalytic': [2], 'spliceosomes': [3, 139], 'contain': [4], 'several': [5], 'proteins': [6], 'that': [7, 21, 38, 73, 124], 'associate': [8], 'transiently': [9], 'just': [10], 'prior': [11], 'to': [12, 140], 'spliceosome': [13, 78], 'activation': [14], 'and': [15, 45, 53, 58, 75, 80, 96, 112, 126], 'are': [16, 59, 81, 118], 'absent': [17], 'in': [18, 28], 'yeast,': [19], 'suggesting': [20], 'this': [22, 84], 'critical': [23], 'step': [24, 85], 'is': [25, 100], 'more': [26], 'complex': [27], 'higher': [29], 'eukaryotes.': [30], 'We': [31], 'demonstrate': [32], 'via': [33], 'RNAi': [34], 'coupled': [35], 'with': [36, 145], 'RNA-Seq': [37], 'two': [39], 'of': [40, 65, 115, 148], 'these': [41], 'human-specific': [42], 'proteins,': [43], 'Smu1': [44, 74, 125], 'RED,': [46], 'function': [47], 'both': [48], 'as': [49, 54], 'alternative': [50], 'splicing': [51, 56, 64, 70, 147], 'regulators': [52], 'general': [55], 'factors': [57], 'required': [60], 'predominantly': [61], 'for': [62, 83], 'efficient': [63], 'short': [66, 116, 134, 149], 'introns.': [67, 150], 'In': [68], 'vitro': [69], 'assays': [71], 'reveal': [72], 'RED': [76, 127], 'promote': [77], 'activation,': [79], 'essential': [82], 'when': [86, 109], 'the': [87, 90, 110, 146], 'distance': [88], 'between': [89], 'pre-mRNA’s': [91], '5′': [92, 111], 'splice': [93], 'site': [94, 98], '(SS)': [95], 'branch': [97], '(BS)': [99], 'sufficiently': [101], 'short.': [102], 'This': [103], 'Smu1-RED': [104], 'requirement': [105], 'can': [106], 'be': [107], 'bypassed': [108], '3′': [113], 'regions': [114], 'introns': [117], 'physically': [119], 'separated.': [120], 'Our': [121], 'observations': [122], 'suggest': [123], 'relieve': [128], 'physical': [129], 'constraints': [130], 'arising': [131], 'from': [132], 'a': [133], '5′SS-BS': [135], 'distance,': [136], 'thereby': [137], 'enabling': [138], 'overcome': [141], 'structural': [142], 'challenges': [143], 'associated': [144]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2966937658', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-09-13T14:36:12.004367', 'created_date': '2019-08-22'}