Bisecting GlcNAc Is a General Suppressor of Terminal Modification of N-glycan*[S]

Name: Work Video:
Duration: 3 min 30 s
Miyako Nakano; Sushil Kumar Mishra; Yuko Tokoro; Keiko Sato; Kazuki Nakajima; Yoshiki Yamaguchi; Naoyuki Taniguchi; Yasuhiko Kizuka
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'https://openalex.org/W1988473330', 'https://openalex.org/W1986427399', 'https://openalex.org/W1971822912'], 'abstract_inverted_index': {'Glycoproteins': [0, 152], 'are': [1, 16, 153, 168, 333, 338, 865, 974, 1251, 1271, 1334, 1872, 2201, 3338], 'decorated': [2, 154, 1109], 'with': [3, 155, 1110, 1317, 1347, 1384, 1404, 1489, 1498, 1859, 1869, 3391, 3485, 3507, 3576, 3626, 3671, 3698, 3730, 3738, 3755, 3780, 3818, 3836, 3915, 3932, 4005, 4025, 4040], 'complex': [4, 13, 156, 165, 862, 3215], 'glycans': [5, 135, 157, 287, 474, 755, 1868, 2292, 2462], 'for': [6, 79, 158, 231, 844, 1331, 1960, 2177, 2361, 2501, 2688, 2820, 2960, 3033, 3086, 3167, 3336, 3491, 3560, 3596, 3634, 3642, 3655, 3689, 3722, 3732, 3740, 3752, 3783, 3793, 3831, 3870, 3896, 3953, 3978, 4002], 'protein': [7, 150, 159, 302, 336, 353, 414, 427, 993, 1031, 1574, 3746, 3798], 'functions.': [8, 160], 'However,': [9, 161, 849, 2390], 'regulation': [10, 147, 162, 299, 1700, 2185, 2503], 'mechanisms': [11, 163, 378, 452, 767, 792, 859], 'of': [12, 34, 37, 51, 64, 99, 110, 124, 149, 164, 186, 189, 203, 216, 251, 262, 276, 301, 316, 379, 398, 453, 473, 482, 588, 620, 650, 731, 733, 739, 743, 753, 768, 814, 854, 860, 1013, 1048, 1051, 1072, 1081, 1088, 1113, 1168, 1191, 1226, 1258, 1268, 1296, 1306, 1327, 1360, 1371, 1428, 1464, 1538, 1594, 1614, 1662, 1683, 1693, 1701, 1704, 1717, 1720, 1751, 1783, 1829, 1839, 1846, 1876, 1912, 1945, 1950, 1972, 1998, 2010, 2044, 2087, 2159, 2218, 2226, 2244, 2286, 2290, 2318, 2325, 2332, 2349, 2364, 2380, 2387, 2400, 2424, 2436, 2492, 2496, 2504, 2655, 2675, 2719, 2764, 2771, 2879, 2918, 2928, 2954, 2999, 3036, 3080, 3096, 3132, 3216, 3222, 3259, 3266, 3301, 3361, 3477, 3483, 3494, 3520, 3579, 3610, 3616, 3619, 3674, 3701, 3810, 3821, 3849, 3877, 3880, 3943, 3966, 3987, 4028, 4076], 'glycan': [14, 166, 404, 838, 863, 1284, 2505, 2821, 3168, 3362], 'biosynthesis': [15, 33, 167, 185, 1047, 1190, 1295, 1971, 1997, 2379, 2399, 3221, 3265], 'largely': [17, 169], 'unclear.': [18, 170], 'Here': [19, 171], 'we': [20, 172, 2417], 'found': [21, 173, 1608, 2429], 'that': [22, 106, 133, 174, 258, 285, 835, 984, 1015, 1184, 1824, 1867, 2215, 2346, 2370, 2450, 2484, 3188], 'bisecting': [23, 65, 175, 217, 1297, 1595, 1797, 1830, 1851, 1870, 2112, 2219, 2351, 2365, 2371, 2395, 2411, 2485, 2681, 2919], 'GlcNAc,': [24, 66, 176, 218, 1298, 1424], 'a': [25, 86, 90, 145, 177, 238, 242, 297, 330, 711, 841, 852, 1064, 1069, 1247, 1439, 1615, 1833, 2095, 2287, 2350, 2489, 2704, 2850, 2867, 2946, 2958, 2990, 3037, 3072, 3084, 3488, 3542, 3550, 3808, 3811, 4045, 4074], 'branching': [26, 178, 2179], 'sugar': [27, 179, 586, 1104, 1536, 1660, 2122, 2206, 2319], 'residue': [28, 180, 2353], 'in': [29, 40, 54, 58, 75, 115, 181, 192, 206, 210, 227, 267, 376, 450, 475, 594, 655, 710, 765, 790, 816, 868, 995, 1017, 1033, 1053, 1063, 1261, 1273, 1281, 1286, 1302, 1432, 1502, 1544, 1668, 1685, 1690, 1696, 1820, 1920, 1969, 2186, 2241, 2248, 2321, 2403, 2432, 2683, 3263, 3306, 3340, 3369, 3481, 3517, 3607, 3769, 3826, 3846, 3940, 4093], 'N-glycan,': [30, 182], 'suppresses': [31, 183], 'the': [32, 61, 107, 111, 121, 125, 184, 213, 259, 263, 273, 277, 307, 403, 480, 857, 987, 996, 1009, 1034, 1046, 1054, 1084, 1189, 1262, 1266, 1274, 1282, 1294, 1318, 1348, 1385, 1405, 1425, 1444, 1691, 1825, 1837, 1844, 1913, 1957, 1970, 2004, 2216, 2223, 2347, 2362, 2375, 2385, 2398, 2444, 2656, 2676, 2680, 2760, 2876, 2925, 2951, 2967, 2996, 3077, 3093, 3120, 3192, 3264, 3492, 3611, 3620, 3665, 3692, 3726, 3748, 3786, 3803, 3860, 3863, 3875, 3893, 3900, 3921, 3961, 3972, 3983, 3994, 4070], 'various': [35, 187, 409, 483, 1089, 1111, 1259, 2433, 2493], 'types': [36, 188, 1112], 'terminal': [38, 112, 190, 264, 1114, 1192, 2434, 2494], 'epitopes': [39, 53, 114, 191, 205, 266], 'N-glycans,': [41, 193, 2382, 2437, 2497], 'including': [42, 194, 485, 2027, 2438], 'fucose,': [43, 195, 2440], 'sialic': [44, 196, 917, 968, 1122, 2441], 'acid': [45, 197, 883, 918, 934, 969, 2442, 2549, 3948], 'and': [46, 68, 198, 220, 335, 357, 381, 418, 431, 455, 551, 625, 653, 703, 757, 770, 793, 811, 820, 822, 847, 977, 979, 1060, 1127, 1134, 1255, 1300, 1312, 1322, 1342, 1366, 1378, 1399, 1434, 1462, 1483, 1780, 1805, 1953, 1967, 2007, 2017, 2042, 2068, 2085, 2125, 2180, 2183, 2211, 2239, 2329, 2378, 2421, 2443, 2476, 2540, 2571, 2673, 2690, 2736, 2766, 2776, 2816, 2823, 2855, 2873, 2948, 2986, 3074, 3109, 3117, 3130, 3163, 3170, 3196, 3218, 3277, 3282, 3298, 3303, 3397, 3432, 3534, 3546, 3569, 3589, 3637, 3664, 3677, 3705, 3736, 3805, 3834, 3862, 3882, 3899, 3920, 3925, 4012, 4033, 4078], 'human': [47, 199, 749, 894, 945, 1128, 2096, 3055, 3097, 3103, 3224], 'natural': [48, 200, 504, 534, 895, 946, 1129, 3225], 'killer-1.': [49, 201], 'Expression': [50, 202], 'these': [52, 204, 1269, 1840], 'N-glycan': [55, 80, 88, 113, 207, 232, 240, 265, 734, 744, 1073, 1240, 1429, 2178, 2401, 2415, 2455], 'was': [56, 69, 102, 208, 221, 254, 1484, 1607, 2469, 2519, 2614, 2622, 2633, 2645, 2744, 2784, 2844, 2871, 2890, 2972, 3003, 3057, 3574, 3605, 3630, 3662, 3669, 3728, 3750, 3788, 3857, 3913, 3969, 3991, 4010, 4015], 'elevated': [57, 108, 209, 260], 'mice': [59, 117, 211, 269, 476, 1314, 1330, 1344, 1368, 1401, 1493, 1776, 2658, 2701, 2709, 2728], 'lacking': [60, 212], 'biosynthetic': [62, 126, 214, 278, 1011], 'enzyme': [63, 215, 3214, 3437], 'GnT-III,': [67, 219], 'conversely': [70, 222], 'suppressed': [71, 223], 'by': [72, 139, 224, 291, 341, 708, 1093, 1097, 1253, 1438, 1443, 1612, 1724, 1842, 1917, 1976, 2120, 2251, 2472, 2616, 2624, 2635, 2647, 2713, 2759, 2846, 2848, 2892, 2974, 2993, 3005, 3059, 3327, 3399, 3434, 3554, 3614, 3646, 3649, 3874, 3950, 3975, 3997, 4035], 'GnT-III': [73, 225, 1441, 1684, 2887, 2895, 3098], 'overexpression': [74, 226, 1682], 'cells.': [76, 228, 870, 3571], 'Many': [77, 229], 'glycosyltransferases': [78, 230, 1260, 1270, 1878, 2452], 'terminals': [81, 233, 2456], 'were': [82, 136, 234, 288, 1315, 1345, 1382, 1402, 2513, 2603, 2702, 2710, 2723, 2757, 3115, 3324, 3348, 3515, 3696, 3800, 3816, 3865, 3890, 3905, 3923, 3930, 4022, 4042], 'revealed': [83, 235, 1866, 2250], 'to': [84, 92, 120, 236, 244, 272, 402, 616, 837, 1068, 1277, 1486, 1609, 1626, 1756, 1955, 2204, 2294, 2408, 2778, 2881, 2922, 2956, 3082, 3101, 3107, 3113, 3403, 3566, 3859, 3907, 3971, 3993], 'prefer': [85, 237], 'nonbisected': [87, 134, 239, 286, 2466], 'as': [89, 241, 413, 1117, 2463, 2488, 2514, 2866, 2945, 2989, 3071, 3509], 'substrate': [91, 122, 243, 274, 2330], 'its': [93, 245, 591, 1541, 1665, 2357, 2499], 'bisected': [94, 246, 2291, 2461], 'counterpart,': [95, 247], 'whereas': [96, 248, 1774, 2197], 'no': [97, 249, 1873], 'up-regulation': [98, 250], 'their': [100, 252, 342, 2181], 'mRNAs': [101, 253], 'found.': [103, 255], 'This': [104, 256, 1606], 'indicates': [105, 257], 'expression': [109, 261, 752, 1463], 'GnT-III-deficient': [116, 268], 'is': [118, 270, 306, 851, 1021, 1057, 1061, 1083, 1353, 1410, 1436, 2359, 2392, 3031], 'attributed': [119, 271], 'specificity': [123, 275], 'enzymes.': [127, 279], 'Molecular': [128, 280], 'dynamics': [129, 281, 900, 951, 2254, 2478], 'simulations': [130, 282], 'further': [131, 283, 1108, 2118, 2470, 3976], 'confirmed': [132, 284], 'preferentially': [137, 289], 'accepted': [138, 290], 'those': [140, 292], 'glycosyltransferases.': [141, 293], 'These': [142, 294, 1819, 2367, 2481], 'findings': [143, 295], 'unveil': [144, 296], 'new': [146, 298], 'mechanism': [148, 300], 'N-glycosylation.': [151, 303], 'Protein': [304], 'glycosylation': [305, 344, 624, 994, 1032, 1750], 'most': [308, 982, 2451], 'abundant': [309], 'post-translational': [310], 'modification': [311, 587, 1537, 1571, 1661], '(1Varki': [312], 'A.': [313, 668, 1144, 1202, 1450, 1709, 1890, 2073, 2135, 2311, 3355, 3466], 'Biological': [314], 'roles': [315], 'glycans.Glycobiology.': [317], '2017;': [318, 3442], '27:': [319], '3-49Crossref': [320], 'PubMed': [321, 366, 391, 440, 465, 602, 632, 662, 723, 780, 801, 829, 1003, 1041, 1480, 1552, 1583, 1601, 1676, 1736, 1769, 1814, 1933, 1985, 2022, 2063, 2105, 2192, 2265, 2301, 2342, 2695, 2836, 2940, 3047, 3183, 3239, 3272, 3319, 3385, 3450, 3502], 'Scopus': [322, 367, 392, 441, 466, 603, 633, 663, 724, 781, 802, 830, 1004, 1042, 1553, 1584, 1602, 1677, 1737, 1770, 1815, 1934, 1986, 2023, 2064, 2106, 2193, 2266, 2302, 2696, 2837, 2941, 3048, 3184, 3240, 3273, 3320, 3386, 3451, 3503], '(1209)': [323], 'Google': [324, 369, 394, 443, 468, 605, 635, 665, 726, 783, 804, 832, 1006, 1044, 1481, 1555, 1586, 1604, 1679, 1739, 1772, 1817, 1936, 1988, 2025, 2066, 2108, 2195, 2268, 2304, 2343, 2698, 2839, 2943, 3050, 3186, 3242, 3275, 3322, 3388, 3453, 3505], 'Scholar).': [325, 395, 469, 727, 1007, 1180, 1238, 1605, 1680, 1818, 2109, 2699, 2840, 3051], 'Glycan': [326], 'structures': [327, 405, 839, 864, 1074, 1241, 2402, 2506], 'even': [328, 1246], 'on': [329, 406, 981, 1075, 1242, 1799, 1836, 2003, 2454, 2507, 2751, 3365, 3479, 3632, 3747, 4044], 'single': [331, 1248], 'glycoprotein': [332, 1244, 1946], 'diverse,': [334], 'functions': [337, 1593, 1845], 'dynamically': [339, 866], 'regulated': [340, 1062, 1272], 'specific': [343, 2295], 'states': [345], '(2Moremen': [346, 420], 'K.W.': [347, 421], 'Tiemeyer': [348, 422], 'M.': [349, 423, 567, 573, 638, 678, 686, 991, 1029, 1141, 1154, 1199, 1212, 1454, 1517, 1523, 1560, 1641, 1647, 1707, 1742, 1888, 1894, 1904, 2040, 2077, 2132, 2145, 2271, 2273, 2666, 2794, 2804, 3141, 3151, 3210, 3351, 3357, 3409, 3456, 3468], 'Nairn': [350, 424], 'A.V.': [351, 425], 'Vertebrate': [352, 426], 'glycosylation:': [354, 428], 'diversity,': [355, 429], 'synthesis': [356, 430], 'function.Nat.': [358, 432], 'Rev.': [359, 433, 796], 'Mol.': [360, 434], 'Cell': [361, 435, 1980], 'Biol.': [362, 436, 1472, 1759, 1923, 1981, 2053, 2334, 2827, 2930, 3174, 3229, 3309, 3441], '2012;': [363, 437], '13:': [364, 438], '448-462Crossref': [365, 439], '(1111)': [368, 442], 'Scholar,': [370, 444, 606, 636, 666, 784, 805, 1556, 1587, 1740, 1937, 1989, 2171, 2269, 2305, 3454], '3Ohtsubo': [371, 445], 'K.': [372, 446, 608, 670, 674, 761, 1456, 1896, 2081, 2275, 2796, 2901, 3019, 3143, 3413, 3417], 'Marth': [373, 447, 613, 762, 2669, 2717], 'J.D.': [374, 448, 614, 763, 1148, 1206, 1791, 2139, 2670], 'Glycosylation': [375, 449, 764, 789], 'cellular': [377, 451, 766], 'health': [380, 454, 769], 'disease.Cell.': [382, 456, 771], '2006;': [383, 457, 772, 3311], '126:': [384, 458, 773, 827], '855-867Abstract': [385, 459, 774], 'Full': [386, 388, 460, 462, 718, 720, 775, 777, 1477, 1764, 1766, 1928, 1930, 2058, 2060, 2260, 2262, 2339, 2831, 2833, 2935, 2937, 3178, 3180, 3234, 3236, 3314, 3316, 3380, 3382, 3445, 3447], 'Text': [387, 389, 461, 463, 719, 721, 776, 778, 1478, 1765, 1767, 1929, 1931, 2059, 2061, 2261, 2263, 2340, 2832, 2834, 2936, 2938, 3179, 3181, 3235, 3237, 3315, 3317, 3381, 3383, 3446, 3448], 'PDF': [390, 464, 722, 779, 1479, 1768, 1932, 2062, 2264, 2341, 2835, 2939, 3182, 3238, 3318, 3384, 3449], '(2087)': [393, 467, 782], 'Indeed,': [396], 'alteration': [397], 'or': [399, 478, 1086, 1245, 1370, 1388, 1827, 2726, 3125], 'dynamic': [400], 'changes': [401, 836, 2240], 'proteins': [407, 983, 3368, 3695], 'affect': [408], 'physiological': [410], 'processes,': [411], 'such': [412, 1116], 'folding,': [415], 'stability,': [416], 'trafficking': [417], 'activity': [419], 'Further,': [470, 1681], 'genetic': [471, 2182, 2706], 'deletion': [472], 'improved': [477, 1495], 'accelerated': [479], 'pathology': [481, 1497], 'diseases': [484, 1841], 'cancer,': [486, 736], "Alzheimer's": [487, 595, 871, 922, 1545, 1669, 3024], 'disease': [488, 845, 872, 923], '(AD)': [489], '1The': [490, 520], 'abbreviations': [491, 521], 'used': [492, 522, 2512, 3335], "are:ADAlzheimer's": [493, 523], 'diseaseERendoplasmic': [494, 524], 'reticulumAALAleuria': [495, 525], 'aurantia': [496, 526, 876, 927], 'lectinE4-PHAerythroagglutinating': [497, 527], 'phytohemagglutininFucfucoseGalgalactoseGlcAglucuronic': [498, 528], 'acidGlcNAcN-acetylglucosamineGluA2AMPA-type': [499, 529], 'glutamate': [500, 530, 886, 937], 'receptor-2′GGnGGnbiGal-terminated': [501, 531], 'biantennaryGnGnbiGlcNAc-terminated': [502, 532], 'biantennaryGnTN-acetylglucosaminyltransferaseHexhexoseHNK-1human': [503, 533], 'killer-1LacNAcN-acetyllactosamineLeLewisMDmolecular': [505, 535], 'dynamicsManmannoseMAMMaakia': [506, 536], 'amurensis': [507, 537, 903, 954, 2600], 'lectinNCAMneural': [508, 538], 'cell': [509, 539, 623, 906, 957, 2099, 3366, 3430], 'adhesion': [510, 540, 907, 958], 'moleculePApyridylaminePhoSLPholiota': [511, 541], 'squarrosa': [512, 542, 911, 962, 2611], 'lectinRMSFroot': [513, 543], 'mean': [514, 544, 914, 965], 'square': [515, 545, 915, 966], 'fluctuationsSiasialic': [516, 546], 'acidSSASambucus': [517, 547], 'sieboldiana': [518, 548, 920, 971, 2596], 'lectin.': [519, 921, 972], 'lectin.,': [549], 'diabetes': [550, 617], 'muscle': [552], 'dystrophy': [553, 702], '(4Kizuka': [554, 1504, 1628], 'Y.': [555, 569, 571, 809, 1452, 1505, 1519, 1521, 1558, 1589, 1629, 1643, 1645, 1711, 1744, 1746, 1787, 1884, 2034, 2173, 2234, 2236, 2279, 2283, 2788, 2802, 2913, 3015, 3023, 3135, 3149, 3204, 3249, 3251, 3286, 3292, 3407, 3411, 3470], 'Kitazume': [556, 1506, 1561, 1630, 2799, 3008, 3146], 'S.': [557, 577, 684, 1507, 1527, 1562, 1631, 1651, 1713, 1793, 1880, 1892, 1993, 2030, 2230, 2277, 2307, 2790, 2800, 2903, 2911, 3013, 3137, 3147, 3212, 3247, 3253, 3296], 'Fujinawa': [558, 1508, 1632], 'R.': [559, 646, 688, 1509, 1633, 1886, 1908, 2313, 2798, 3017, 3145, 3353, 3415], 'Saito': [560, 1510, 1563, 1634], 'T.': [561, 581, 680, 694, 698, 700, 1158, 1216, 1511, 1531, 1564, 1635, 1655, 1900, 1902, 2149, 2309, 2897, 3202, 3208, 3255, 3288, 3294, 3458, 3460, 3462, 3464], 'Iwata': [562, 1512, 1636], 'N.': [563, 583, 807, 1139, 1197, 1458, 1513, 1533, 1568, 1591, 1637, 1657, 1715, 1748, 1910, 2036, 2075, 2079, 2083, 2130, 2175, 2232, 2281, 2315, 2814, 2907, 2909, 2915, 3161, 3206, 3425, 3472], 'Saido': [564, 1514, 1565, 1638, 3020], 'T.C.': [565, 1515, 1566, 1639, 3021], 'Nakano': [566, 1516, 1559, 1640, 2793, 3140, 3408], 'Yamaguchi': [568, 1518, 1642, 2078, 2233, 2282, 2801, 3148, 3410], 'Hashimoto': [570, 1520, 1644, 3022], 'Staufenbiel': [572, 1522, 1646], 'Hatsuta': [574, 1524, 1648], 'H.': [575, 579, 672, 676, 682, 696, 1525, 1529, 1649, 1653, 1882, 1906, 1943, 1995, 2038, 2668, 2792, 2806, 2905, 3139, 3153, 3290], 'Murayama': [576, 1526, 1650], 'Manya': [578, 671, 1528, 1652], 'Endo': [580, 699, 1530, 1654], 'Taniguchi': [582, 673, 1138, 1196, 1457, 1532, 1567, 1590, 1656, 1712, 1714, 1747, 1909, 2035, 2082, 2129, 2174, 2280, 2314, 2813, 2914, 3160, 3424, 3471], 'An': [584, 1534, 1658, 3426], 'aberrant': [585, 751, 1535, 1659], 'BACE1': [589, 1539, 1573, 1663], 'blocks': [590, 1540, 1664], 'lysosomal': [592, 1542, 1666], 'targeting': [593, 1543, 1667], 'disease.EMBO': [596, 1546, 1670], 'Mol': [597, 1547, 1671], 'Med.': [598, 628, 658, 1548, 1672], '2015;': [599, 798, 826, 1549, 1673], '7:': [600, 1550, 1674, 2693], '175-189Crossref': [601, 1551, 1675], '(130)': [604, 1554, 1678], '5Ohtsubo': [607], 'Chen': [609], 'M.Z.': [610], 'Olefsky': [611], 'J.M.': [612], 'Pathway': [615], 'through': [618, 986, 1699], 'attenuation': [619], 'pancreatic': [621, 3486], 'beta': [622, 2090], 'glucose': [626], 'transport.Nat.': [627], '2011;': [629, 2257, 3231, 3377], '17:': [630], '1067-1075Crossref': [631], '(172)': [634], '6Granovsky': [637], 'Fata': [639], 'J.': [640, 642, 1579, 1597, 2071, 2256, 3497], 'Pawling': [641], 'Muller': [643], 'W.J.': [644], 'Khokha': [645], 'Dennis': [647], 'J.W.': [648], 'Suppression': [649, 1716], 'tumor': [651, 1808, 3495], 'growth': [652, 1779, 1802], 'metastasis': [654, 1695, 1719, 1782], 'Mgat5-deficient': [656], 'mice.Nat.': [657], '2000;': [659], '6:': [660, 2299], '306-312Crossref': [661], '(468)': [664], '7Yoshida': [667], 'Kobayashi': [669], 'Kano': [675], 'Mizuno': [677], 'Inazu': [679], 'Mitsuhashi': [681], 'Takahashi': [683], 'Takeuchi': [685, 2039], 'Herrmann': [687], 'Straub': [689], 'V.': [690], 'Talim': [691], 'B.': [692], 'Voit': [693], 'Topaloglu': [695], 'Toda': [697], 'Muscular': [701], 'neuronal': [704], 'migration': [705, 3431], 'disorder': [706], 'caused': [707, 1611], 'mutations': [709], 'glycosyltransferase,': [712], 'POMGnT1.Dev.': [713], 'Cell.': [714, 3375], '2001;': [715, 1925, 2932, 3044], '1:': [716], '717-724Abstract': [717], '(645)': [725], 'For': [728], 'example,': [729], 'loss': [730, 738], 'β1,6-branch': [732], 'improves': [735], 'where': [737], 'another': [740], 'branch': [741, 1105, 1185, 1427], '(β1,4-branch)': [742], 'causes': [745], 'type-2': [746], 'diabetes.': [747], 'In': [748, 1849, 2110, 2405], 'patients,': [750], 'disease-relevant': [754], 'promoted': [756], 'affected': [758], 'pathogenesis': [759], '(3Ohtsubo': [760], '8Pinho': [785], 'S.S.': [786], 'Reis': [787], 'C.A.': [788], 'cancer:': [791, 812, 3487], 'clinical': [794], 'implications.Nat.': [795], 'Cancer.': [797, 3498], '15:': [799, 3270], '540-555Crossref': [800], '(1612)': [803], '9Taniguchi': [806], 'Kizuka': [808, 2278, 3203], 'Glycans': [810], 'role': [813, 2009], 'N-glycans': [815, 973, 1014, 1052, 1082, 1800, 1975, 2228, 2247, 3478, 3902, 3929], 'cancer': [817, 1785, 2098], 'biomarker,': [818], 'progression': [819], 'metastasis,': [821], 'therapeutics.Adv.': [823], 'Cancer': [824], 'Res.': [825, 1810], '11-51Crossref': [828], '(261)': [831], 'Scholar),': [833, 1045, 1773, 2026, 2196, 2344, 3243, 3276, 3389], 'indicating': [834], 'represent': [840], 'direct': [842], 'target': [843, 1847, 2388], 'diagnosis': [846], 'therapy.': [848], 'there': [850], 'paucity': [853], 'information': [855], 'describing': [856, 1293], 'detailed': [858], 'how': [861, 1265, 2394], 'formed': [867], 'living': [869], 'endoplasmic': [873, 924, 1018], 'reticulum': [874, 925, 1019], 'Aleuria': [875, 926, 2585], 'lectin': [877, 904, 912, 928, 955, 963, 2593, 2612], 'erythroagglutinating': [878, 929, 2590], 'phytohemagglutinin': [879, 930, 2591], 'fucose': [880, 931, 1126, 2818, 3165], 'galactose': [881, 932], 'glucuronic': [882, 933], 'N-acetylglucosamine': [884, 935, 2682, 2920], 'AMPA-type': [885, 936], 'receptor-2′': [887, 938], 'Gal-terminated': [888, 939], 'biantennary': [889, 891, 940, 942, 2245], 'GlcNAc-terminated': [890, 941], 'N-acetylglucosaminyltransferase': [892, 943, 1725, 1918], 'hexose': [893, 944], 'killer-1': [896, 947, 1130, 3226], 'N-acetyllactosamine': [897, 948, 1118], 'Lewis': [898, 949, 1124], 'molecular': [899, 950, 2253, 2477], 'mannose': [901, 952], 'Maakia': [902, 953], 'neural': [905, 956], 'molecule': [908, 959, 2328], 'pyridylamine': [909, 960], 'Pholiota': [910, 961, 2610], 'root': [913, 964], 'fluctuations': [916, 967], 'Sambucus': [919, 970, 2595], 'highly': [975, 1022, 1431, 1973, 1999], 'conserved': [976, 1023], 'abundant,': [978], 'expressed': [980, 1430], 'pass': [985], 'secretory': [988], 'pathway': [989, 1959, 2006], '(10Aebi': [990, 1028], 'N-linked': [992, 1030, 3223], 'ER.Biochim.': [997, 1035], 'Biophys.': [998, 1036], 'Acta.': [999, 1037], '2013;': [1000, 1038], '1833:': [1001, 1039], '2430-2437Crossref': [1002, 1040], '(458)': [1005, 1043], 'Although': [1008], 'early': [1010, 1624, 1781], 'system': [1012], 'occurs': [1016], '(ER)': [1020], 'among': [1024], 'all': [1025], 'eukaryotic': [1026], 'cells': [1027, 1688], 'later': [1049], 'phases': [1050], 'Golgi': [1055, 1275], 'apparatus': [1056], 'very': [1058], 'diverse': [1059], 'protein-selective': [1065], 'manner,': [1066], 'leading': [1067], 'wide': [1070], 'variety': [1071], 'glycoproteins.': [1076, 1848, 2389], 'The': [1077, 1325, 1796, 1948, 1996, 2608, 2618, 2630, 2641, 2653, 2741, 2769, 2916, 3333, 3572, 3602, 3628, 3658, 3745, 3797, 3814, 3888, 3911, 3927, 4008, 4020], 'major': [1078, 1914], 'structural': [1079, 2212], 'diversity': [1080, 2238], 'presence': [1085, 1826, 2217, 2348], 'absence': [1087, 1828], 'GlcNAc': [1090, 1570, 1798, 1831, 1852, 1861, 1871, 2113, 2199, 2220, 2352, 2372, 2396, 2412, 2486], 'branches': [1091, 2200], 'synthesized': [1092], 'N-acetylglucosaminyltransferases': [1094, 1961, 2011], '(GnTs': [1095], 'encoded': [1096], 'MGAT': [1098], 'genes)': [1099], '(supplemental': [1100], 'Fig.': [1101], 'S1).': [1102], 'Each': [1103], 'can': [1106], 'be': [1107, 1278, 1487, 1610], 'modifications': [1115, 1193, 2435, 2495, 3508], '(LacNAc),': [1119], 'LacdiNAc,': [1120], 'αGal,': [1121], 'acid,': [1123], '(Le)-type': [1125], '(HNK-1)': [1131, 3227], '(Fig.': [1132, 1447], '1A': [1133], '2A)': [1135], '(11Stanley': [1136, 1194, 2127], 'P.': [1137, 1150, 1195, 1208, 1795, 2128, 2141], 'Aebi': [1140, 1153, 1198, 1211, 2131, 2144], 'N-Glycans.in:': [1142, 1200, 2133], 'Varki': [1143, 1201, 2134], 'Cummings': [1145, 1203, 2136], 'R.D.': [1146, 1204, 2137], 'Esko': [1147, 1205, 2138], 'Stanley': [1149, 1207, 1794, 2140], 'Hart': [1151, 1209, 2142], 'G.W.': [1152, 1210, 2143], 'Darvill': [1155, 1213, 2146], 'A.G.': [1156, 1214, 2147], 'Kinoshita': [1157, 1215, 2148], 'Packer': [1159, 1217, 2150, 3358], 'N.H.': [1160, 1218, 2151, 3359], 'Prestegard': [1161, 1219, 2152], 'J.H.': [1162, 1220, 2153], 'Schnaar': [1163, 1221, 2154], 'R.L.': [1164, 1222, 2155], 'Seeberger': [1165, 1223, 2156], 'P.H.': [1166, 1224, 2157], 'Essentials': [1167, 1225, 2158], 'Glycobiology.': [1169, 1227, 2160], 'Cold': [1170, 1175, 1228, 1233, 2161, 2166], 'Spring': [1171, 1176, 1229, 1234, 2162, 2167], 'Harbor': [1172, 1230, 2163], 'Lab': [1173, 1231, 2164], 'Press,': [1174, 1232, 2165], 'Harbor,': [1177, 1235, 2168], 'NY2015:': [1178, 1236, 2169], '99-111Google': [1179, 1237, 2170], 'Biochemical': [1181], 'studies': [1182, 1822, 1865, 2002, 2213], 'showed': [1183, 1494, 1777, 1823], 'formation': [1186, 1501], 'basically': [1187, 2115], 'precedes': [1188], 'Final': [1239], 'each': [1243, 1332], 'N-glycosylation': [1249], 'site': [1250, 2878, 2953, 2998, 3079, 3122, 3127], 'biosynthesized': [1252, 1437], 'concerted': [1254], 'competitive': [1256], 'actions': [1257, 1267], 'Golgi,': [1263], 'but': [1264, 2355], 'remains': [1276], 'elucidated.Fig.': [1279], '2Increase': [1280], 'HNK-1': [1283, 1299, 2445, 3267, 3307], 'level': [1285], 'Mgat3−/−': [1287, 1313, 1343, 1367, 1379, 1400], 'brain.': [1288, 2427], 'A,': [1289], 'A': [1290, 2964, 3052, 3764], 'schematic': [1291], 'model': [1292], 'polySia': [1301], 'N-glycans.': [1303], 'B,': [1304], 'Proteins': [1305, 1359], 'brain': [1307, 1361, 1433, 1503, 3346], 'membranes': [1308, 3347], 'from': [1309, 1339, 1363, 1376, 1396, 1469, 1623, 2049, 2094, 2520, 2527, 2533, 2544, 2552, 2560, 2569, 2578, 2604, 2703, 2980, 3345, 3802], '7-week-old': [1310], 'Mgat3+/+': [1311, 1341, 1365, 1377, 1398], 'stained': [1316, 1383, 3751], 'anti-HNK-1,': [1319], 'anti-NCAM,': [1320], 'anti-GluA2': [1321], 'anti-VDAC1': [1323, 2525], 'Ab.': [1324, 1392], 'data': [1326, 2482], 'two': [1328, 3260, 4079], 'representative': [1329], 'genotype': [1333], 'shown.': [1335, 1354, 1411], 'C,': [1336], 'Brain': [1337, 1394], 'sections': [1338, 1395], '20-week-old': [1340, 1397], 'immunostained': [1346, 1403], 'anti-HNK-1': [1349, 2558], 'mAb.': [1350, 1407], 'Hippocampus': [1351, 1408], 'area': [1352, 1409], 'Bar,': [1355, 1412], '300': [1356, 1413], 'μm.': [1357], 'D,': [1358], 'homogenates': [1362], 'P0': [1364], '(left)': [1369], 'DIV15': [1372], 'cultured': [1373], 'cerebral': [1374], 'neurons': [1375], 'embryos': [1380], '(right)': [1381], 'anti-polySia,': [1386], 'anti-actin,': [1387], 'anti-βIII-tubulin': [1389], '(neuron': [1390], 'marker)': [1391], 'E,': [1393], 'anti-polySia': [1406], 'μm.View': [1414], 'Large': [1415], 'Image': [1416], 'Figure': [1417], 'ViewerDownload': [1418], 'Hi-res': [1419], 'image': [1420], 'Download': [1421], '(PPT)': [1422], 'Bisecting': [1423, 1569], 'central': [1426], 'kidney,': [1435], 'glycosyltransferase': [1440], '(encoded': [1442], 'MGAT3': [1445], 'gene)': [1446], '1A)': [1448], '(12Nishikawa': [1449], 'Ihara': [1451, 1710, 1743, 2033, 2904], 'Hatakeyama': [1453], 'Kangawa': [1455, 2080], 'Purification,': [1459], 'cDNA': [1460, 2843, 2853, 2870, 2889, 2965, 3053], 'cloning,': [1461], 'UDP-N-acetylglucosamine:': [1465, 2045, 2088], 'beta-D-mannoside': [1466], 'beta-1,4N-acetylglucosaminyltransferase': [1467], 'III': [1468, 1726, 1919], 'rat': [1470, 2969, 3283], 'kidney.J.': [1471], 'Chem.': [1473, 1760, 1924, 2054, 2335, 2826, 2931, 3173, 3230, 3310, 3440], '1992;': [1474], '267:': [1475], '18199-18204Abstract': [1476], 'Scholar)': [1482, 2067, 2944, 3187, 3323, 3506], 'reported': [1485], 'associated': [1488], 'several': [1490], 'diseases.': [1491], 'Mgat3-deficient': [1492, 1775, 2425, 2657, 2708], 'AD': [1496], 'reduced': [1499], 'amyloid-plaque': [1500], '13Kizuka': [1557], 'stabilizes': [1572], 'under': [1575, 4069], 'oxidative': [1576], 'stress': [1577], 'conditions.Biochem.': [1578], '2016;': [1580, 2188, 2298, 2828, 3175], '473:': [1581], '21-30Crossref': [1582], '(52)': [1585], '14Kizuka': [1588], 'Neural': [1592], 'GlcNAc.Glycoconj': [1596], '2018;': [1598], '35:': [1599], '345-351Crossref': [1600], '(25)': [1603], 'relocation': [1613], 'key': [1616], 'amyloid-producing': [1617], 'enzyme,': [1618, 3030], 'beta-site': [1619, 3026], 'APP-cleaving': [1620], 'enzyme-1': [1621], '(BACE1),': [1622], 'endosomes': [1625], 'lysosomes': [1627], 'B16': [1686, 1721], 'melanoma': [1687, 1723], 'resulted': [1689], 'prevention': [1692], 'lung': [1694, 1718, 2097], 'mice,': [1697], 'probably': [1698], 'membrane': [1702, 3367, 3603, 3694, 3727, 3749, 3787, 3804], 'retention': [1703], 'E-cadherin': [1705, 1752, 2923], '(15Yoshimura': [1706], 'Nishikawa': [1708, 2072, 2310], 'mouse': [1722, 2426, 2677, 2851], 'gene': [1727], 'transfection.Proc.': [1728], 'Natl.': [1729, 3040], 'Acad.': [1730, 3041], 'Sci.': [1731, 3042], 'U.S.A.': [1732, 3043], '1995;': [1733], '92:': [1734], '8754-8758Crossref': [1735], '(255)': [1738], '16Yoshimura': [1741], 'Matsuzawa': [1745, 2912], 'Aberrant': [1749], 'enhances': [1753], 'cell-cell': [1754], 'binding': [1755], 'suppress': [1757], 'metastasis.J.': [1758], '1996;': [1761], '271:': [1762], '13811-13815Abstract': [1763], '(180)': [1771], 'rapid': [1778], 'breast': [1784], '(17Song': [1786], 'Aglipay': [1788], 'J.A.': [1789], 'Bernstein': [1790], 'Goswami': [1792], 'inhibits': [1801], 'factor': [1803], 'signaling': [1804], 'retards': [1806], 'mammary': [1807], 'progression.Cancer': [1809], '2010;': [1811], '70:': [1812, 2020], '3361-3371Crossref': [1813], '(83)': [1816], 'vivo': [1821], 'has': [1832, 1853, 2659], 'significant': [1834, 2430], 'impact': [1835], 'development': [1838, 3493], 'regulating': [1843], 'addition,': [1850, 2111], 'unique': [1854], 'biochemical': [1855, 2422], 'features': [1856], 'when': [1857], 'compared': [1858], 'other': [1860, 1877, 2121, 2198, 2205], 'branches.': [1862], 'Previous': [1863], 'enzymatic': [1864], 'longer': [1874], 'substrates': [1875, 1952, 2464], '(18Miyagawa': [1879], 'Murakami': [1881], 'Takahagi': [1883], 'Nakai': [1885], 'Yamada': [1887], 'Murase': [1889], 'Koyota': [1891], 'Koma': [1893], 'Matsunami': [1895], 'Fukuta': [1897], 'D.': [1898, 2716], 'Fujimura': [1899], 'Shigehisa': [1901], 'Okabe': [1903], 'Nagashima': [1905], 'Shirakura': [1907], 'Remodeling': [1911], 'pig': [1915], 'xenoantigen': [1916], 'transgenic': [1921], 'pig.J.': [1922], '276:': [1926, 2933], '39310-39319Abstract': [1927], '(94)': [1935, 1987, 2697], '19Brockhausen': [1938], 'I.': [1939, 1991], 'Carver': [1940], 'J.P.': [1941], 'Schachter': [1942, 1994, 2667], 'Control': [1944], 'synthesis.': [1947], 'use': [1949], 'oligosaccharide': [1951], 'HPLC': [1954, 4063], 'study': [1956], 'sequential': [1958, 2005], 'I,': [1962, 2012], 'II,': [1963, 2013], 'III,': [1964, 2014], 'IV,': [1965, 2015], 'V,': [1966], 'VI': [1968], 'branched': [1974, 2000], 'hen': [1977], 'oviduct': [1978], 'membranes.Biochem.': [1979], '1988;': [1982, 2019], '66:': [1983], '1134-1151Crossref': [1984], '20Brockhausen': [1990], 'Narasimhan': [1992], 'N-glycans:': [2001], 'functional': [2008, 3299], 'V': [2016], 'VI.Biochimie.': [2018], '1521-1533Crossref': [2021], '(76)': [2024, 3387], 'GnT-IV': [2028], '(21Oguri': [2029], 'Minowa': [2031], 'M.T.': [2032], 'Ikenaga': [2037], 'Purification': [2041, 2084], 'characterization': [2043, 2086, 2672], 'alpha1,3-D-mannoside': [2046], 'beta1,4-N-acetylglucosaminyltransferase': [2047], '(N-acetylglucosaminyltransferase-IV)': [2048], 'bovine': [2050], 'small': [2051], 'intestine.J.': [2052], '1997;': [2055, 2692], '272:': [2056], '22721-22727Abstract': [2057], '(55)': [2065], 'GnT-V': [2069], '(22Gu': [2070], 'Tsuruoka': [2074], 'Ohno': [2076], 'alpha-6-D-mannoside': [2089], '1–6N-acetylglucosaminyltransferase': [2091], '(N-acetylglucosaminyltransferase': [2092], 'V)': [2093], 'line.J.': [2100], 'Biochem.': [2101], '1993;': [2102], '113:': [2103], '614-619Crossref': [2104], '(137)': [2107], 'does': [2114], 'not': [2116, 2356], 'undergo': [2117], 'elongation': [2119], 'residues': [2123, 2921], '(Gal': [2124], 'Sia)': [2126], '23Kizuka': [2172], 'Enzymes': [2176], 'nongenetic': [2184], 'cancer.Biomolecules.': [2187], '6': [2189], '(pii):': [2190], 'E25Crossref': [2191], '(90)': [2194], 'usually': [2202], 'linked': [2203], 'residues.': [2207], 'Moreover,': [2208], 'previous': [2209, 3404], 'simulation': [2210], 'indicated': [2214], 'substantially': [2221], 'changed': [2222], 'preferable': [2224], 'conformations': [2225], 'whole': [2227, 2381, 2414], '(24Re': [2229], 'Miyashita': [2231], 'Sugita': [2235], 'Structural': [2237, 2316], 'conformational': [2242], 'equilibria': [2243], 'complex-type': [2246], 'water': [2249, 3739, 3837, 3881, 3916], 'replica-exchange': [2252], 'simulation.Biophys.': [2255], '101:': [2258], 'L44-L46Abstract': [2259], '(36)': [2267], '25Nagae': [2270], 'Kanagawa': [2272], 'Morita-Matsumoto': [2274], 'Hanashima': [2276], 'Atomic': [2284], 'visualization': [2285], 'flipped-back': [2288], 'conformation': [2289], 'bound': [2293], 'lectins.Sci.': [2296], 'Rep.': [2297], '22973Crossref': [2300], '(34)': [2303], '26Fujii': [2306], 'Nishiura': [2308], 'Miura': [2312], 'heterogeneity': [2317], 'chains': [2320], 'immunoglobulin': [2322, 2326], 'G.': [2323], 'Conformation': [2324], 'G': [2327], 'specificities': [2331, 3258], 'glycosyltransferases.J.': [2333], '1990;': [2336], '265:': [2337], '6009-6018Abstract': [2338], 'suggesting': [2345], 'itself,': [2354], 'elongation,': [2358], 'important': [2360], 'function': [2363, 2386], 'GlcNAc.': [2366], 'results': [2368], 'indicate': [2369, 2483], 'uniquely': [2373], 'affects': [2374, 2397], 'tertiary': [2376], 'structure': [2377, 3363], 'which': [2383, 2468], 'modulates': [2384], 'it': [2391], 'unclear': [2393], 'vivo.': [2404], 'this': [2406], 'study,': [2407], 'understand': [2409], 'whether': [2410], 'regulates': [2413], 'structures,': [2416], 'carried': [2418], 'out': [2419], 'N-glycomic': [2420], 'analysis': [2423, 3476], 'We': [2428, 2447], 'increases': [2431], 'Le-type': [2439], 'epitope.': [2446], 'also': [2448], 'reveal': [2449], 'acting': [2453], 'have': [2457], 'lower': [2458, 3666], 'preference': [2459], 'toward': [2460], 'over': [2465], 'glycans,': [2467], 'supported': [2471], 'our': [2473], 'docking': [2474], 'models': [2475], '(MD)': [2479], 'simulations.': [2480], 'serves': [2487], 'general': [2490], 'suppressor': [2491], 'highlighting': [2498], 'importance': [2500], 'fine': [2502], 'proteins.': [2508], 'Commercially': [2509], 'available': [2510], 'antibodies': [2511], 'follows:': [2515], 'anti-ST6GAL1': [2516], '(M2,': [2517], '28047)': [2518], 'Immuno-Biological': [2521], 'Laboratories': [2522], '(Gunma,': [2523], 'Japan),': [2524], '(ab14734)': [2526], 'Abcam,': [2528], 'Cambridge,': [2529], 'UK,': [2530], 'anti-actin': [2531], '(A4700)': [2532], 'Sigma,': [2534], 'St': [2535], 'Louis,': [2536], 'MO,': [2537], 'anti-GAPDH': [2538], '(MAB374)': [2539], 'anti-myc': [2541], '(4A6,': [2542], '05–724)': [2543], 'Millipore,': [2545], 'Darmstadt,': [2546], 'Germany,': [2547], 'anti-polysialic': [2548], '(12E3,': [2550], '14–9118-80)': [2551], 'Thermo': [2553, 4057], 'Fisher': [2554, 3395, 3936, 4058], 'Scientific,': [2555, 3937], 'Waltham,': [2556], 'MA,': [2557], '(559048)': [2559], 'BD': [2561], 'Biosciences,': [2562], 'Franklin': [2563], 'Lakes,': [2564], 'NJ,': [2565], 'anti-beta-III-tubulin': [2566], '(tuj1,': [2567], 'MMS-435P)': [2568], 'Covance': [2570], 'anti-myc,': [2572], 'Princeton,': [2573], 'NJ': [2574], '(9E10,': [2575], 'BML': [2576], 'SA-294)': [2577], 'Enzo': [2579], 'Life': [2580], 'Sciences,': [2581], 'Farmingdale,': [2582], 'NY.': [2583], 'Biotinylated': [2584], 'Aurantia': [2586], 'Lectin': [2587], '(AAL)': [2588], '(J201-R),': [2589], '(E4-PHA)': [2592], '(J211),': [2594], '(SSA)': [2597], '(J218),': [2598], 'Maackia': [2599], '(MAM)': [2601], '(J210)': [2602], 'J-Chemical,': [2605], 'Tokyo,': [2606], 'Japan.': [2607], 'biotinylated': [2609], '(PhoSL)': [2613], 'provided': [2615, 2623, 2634, 2646, 2712, 3004, 3326], 'J-Chemical.': [2617], 'anti-GnT-III': [2619], '(clone': [2620], '33A8)': [2621], 'Dr.': [2625, 2636, 2648, 2714, 2981, 3006, 3328], 'Eiji': [2626], 'Miyoshi': [2627, 2898, 3473], '(Osaka': [2628], 'University).': [2629, 2640, 2652, 3332], 'anti-GlcAT-P': [2631], '(GP2)': [2632], 'Shogo': [2637, 3329], 'Oka': [2638, 2797, 3016, 3144, 3211, 3252, 3295, 3330, 3414], '(Kyoto': [2639, 3331], 'anti-Sialyl': [2642], 'Lex': [2643], '(F2)': [2644], 'Hiroto': [2649], 'Kawashima': [2650], '(Chiba': [2651], 'generation': [2654], 'been': [2660], 'described': [2661, 2785], 'previously': [2662, 2786], '(27Priatel': [2663], 'J.J.': [2664], 'Sarkar': [2665], 'Isolation,': [2671], 'inactivation': [2674], 'Mgat3': [2678], 'gene:': [2679], 'asparagine-linked': [2684], 'oligosaccharides': [2685], 'appears': [2686], 'dispensable': [2687], 'viability': [2689], 'reproduction.Glycobiology.': [2691], '45-56Crossref': [2694], 'All': [2700, 2754], 'C57BL/6': [2705], 'background.': [2707], 'generously': [2711], 'Jamey': [2715], '(University': [2718], 'California-Santa': [2720], 'Barbara).': [2721], 'Mice': [2722], 'housed': [2724], '(three': [2725], 'fewer': [2727], 'per': [2729], 'cage)': [2730], 'at': [2731, 2752, 3556, 3563, 3592, 3599, 3639, 3651, 3679, 3685, 3719, 3790, 3867, 3884, 3956, 3999], '23': [2732], '±': [2733, 2738], '3': [2734, 3795], '°C': [2735, 3565, 3641, 3681, 3869, 3886], '55': [2737], '10%': [2739, 3988], 'humidity.': [2740], 'light': [2742], 'condition': [2743], '14': [2745], 'h': [2746, 2749], ':': [2747], '10': [2748, 3378, 3635, 3770, 3847, 3878, 3897, 4029, 4085, 4094], '(lights': [2750], '7:00).': [2753], 'animal': [2755], 'experiments': [2756], 'approved': [2758], 'Animal': [2761], 'Experiment': [2762], 'Committee': [2763], 'RIKEN': [2765], 'Gifu': [2767], 'University.': [2768], 'construction': [2770, 3337], 'pcDNA6-mycHisA/mouse': [2772], 'FUT1,': [2773], 'FUT2,': [2774], 'FUT4': [2775], 'FUT9': [2777], 'express': [2779, 2882], 'C-terminally': [2780, 2883, 2961, 3087], 'myc-tagged': [2781, 2884, 2962, 3088], 'full-length': [2782, 3089, 3278], 'fucosyltransferases': [2783], '(28Kizuka': [2787, 3134], 'Funayama': [2789, 3136], 'Shogomori': [2791, 3138], 'Nakajima': [2795, 3142, 3412], 'Sano': [2803, 3150], 'Korekane': [2805, 3152], 'Hsu': [2807, 3154, 3420], 'T.L.': [2808, 3155, 3421], 'Lee': [2809, 3156], 'H.Y.': [2810, 3157], 'Wong': [2811, 3158, 3422], 'C.H.': [2812, 3159, 3423], 'High-Sensitivity': [2815, 3162], 'low-toxicity': [2817, 3164], 'probe': [2819, 3166], 'imaging': [2822, 3169], 'biomarker': [2824, 3171], 'discovery.Cell': [2825, 3172], '23:': [2829, 3176], '782-792Abstract': [2830, 3177], '(33)': [2838, 3185], 'Mouse': [2841, 3511], 'FUT7': [2842, 2865, 2869], 'amplified': [2845, 2872, 2891, 2973, 3058, 3116], 'PCR': [2847, 2975, 3060], 'using': [2849, 2863, 2893, 2976, 3061, 3541, 3549, 4017, 4060], 'liver': [2852], 'library': [2854], 'then': [2856, 3547, 3590, 3638, 3737], 'ligated': [2857, 3118], 'into': [2858, 2875, 2950, 2995, 3076, 3119, 3807], 'pCR-Blunt': [2859], '(ThermoFisher': [2860], 'Scientific).': [2861], 'By': [2862], 'pCR-Blunt/mouse': [2864], 'template,': [2868, 2991], 'subcloned': [2874], 'EcoRI/XhoI': [2877, 2997, 3078, 3126], 'pcDNA6-mycHisA': [2880, 2955, 3081], 'FUT7.': [2885], 'Human': [2886], '(MGAT3)': [2888], 'pCXN2/human': [2894], '(29Kitada': [2896], 'E.': [2899, 3474], 'Noda': [2900], 'Higashiyama': [2902], 'Matsuura': [2906], 'Hayashi': [2908], 'Kawata': [2910], 'addition': [2917, 3615, 3876], 'down-regulates': [2924], 'tyrosine': [2926], 'phosphorylation': [2927], 'beta-catenin.J.': [2929], '475-480Abstract': [2934], '(88)': [2942], 'template': [2947, 3073], 'cloned': [2949, 3075], 'EcoRI/XbaI': [2952], 'construct': [2957, 3083], 'plasmid': [2959, 3085], 'GnT-III.': [2963], 'encoding': [2966, 3054, 3092, 3191], 'inactive': [2968], 'GnT-IIID321A': [2970, 2978], 'mutant': [2971], 'pCXN2/rat': [2977], '(gift': [2979], 'Tomoya': [2982], 'Isaji,': [2983], 'Tohoku': [2984], 'Medical': [2985, 3010], 'Pharmaceutical': [2987, 3069], 'University)': [2988, 3011, 3070], 'followed': [2992, 3553, 3613, 3645, 3873, 3974, 3996], 'insertion': [2994], 'pcDNA6-mycHisA.': [3000], 'pcDNA3.1/rat': [3001], 'ST6GAL1-FLAG': [3002], 'Shinobu': [3007], '(Fukushima': [3009], '(30Kitazume': [3012], 'Tachida': [3014], 'Shirotani': [3018], 'beta-secretase,': [3025], 'amyloid': [3027], 'precursor': [3028], 'protein-cleaving': [3029], 'responsible': [3032], 'cleavage': [3034], 'secretion': [3035], 'Golgi-resident': [3038], 'sialyltransferase.Proc.': [3039], '98:': [3045], '13554-13559Crossref': [3046], '(231)': [3049], 'ST3GAL4': [3056, 3104, 3129], 'pSVL/human': [3062], 'ST3GAL4-FLAG': [3063], '(STZ)': [3064], '(Dr.': [3065], 'Hiroshi': [3066], 'Kitagawa,': [3067], 'Kobe': [3068], 'ST3GAL4.': [3090], 'cDNAs': [3091], 'catalytic': [3094], 'domains': [3095], '(from': [3099, 3105, 3111], 'Glu63': [3100], 'Val533),': [3102], 'Glu43': [3106], 'Phe332)': [3108], 'ST6GAL1': [3110], 'Lys98': [3112], 'Cys406)': [3114], 'EcoRI/EcoRV': [3121], '(for': [3123, 3128], 'GnT-III)': [3124], 'ST6GAL1)': [3131], 'pcDNA-IH': [3133], 'contains': [3189], 'DNA': [3190], 'Igκ': [3193], 'signal': [3194], 'peptide': [3195], '6xHis': [3197], 'tag.': [3198], 'ProteinA-tagged': [3199], 'B4GALT1': [3200], '(31Kouno': [3201], 'Nakagawa': [3205, 3457], 'Yoshihara': [3207], 'Asano': [3209], 'Specific': [3213], 'beta-1,4-galactosyltransferase-II': [3217], 'glucuronyltransferase-P': [3219], 'facilitates': [3220], 'carbohydrate.J.': [3228], '286:': [3232], '31337-31346Abstract': [3233], '(23)': [3241], 'proteinA-tagged': [3244], 'GlcAT-P': [3245, 3279, 3281], '(32Kakuda': [3246], 'Sato': [3248, 3416], 'Tonoyama': [3250], 'Kawasaki': [3254, 3293], 'Different': [3256], 'acceptor': [3257], 'glucuronyltransferases': [3261, 3302], 'involved': [3262, 3305], 'carbohydrate.Glycobiology.': [3268], '2005;': [3269], '203-210Crossref': [3271], '(26)': [3274], '(pIRES/rat': [3280], 'HNK-1ST)': [3284], '(33Kizuka': [3285], 'Matsui': [3287], 'Takematsu': [3289], 'Kozutsumi': [3291], 'Physical': [3297], 'association': [3300], 'sulfotransferase': [3304], 'biosynthesis.J.': [3308], '281:': [3312], '13644-13651Abstract': [3313], '(43)': [3321], 'kindly': [3325], 'primers': [3334], 'listed': [3339], 'supplemental': [3341], 'Table': [3342], 'S1.': [3343], 'N—Glycans': [3344], 'released': [3349, 3901], '(34Nakano': [3350], 'Saldanha': [3352], 'Gobel': [3354], 'Kavallaris': [3356], 'Identification': [3360], 'alterations': [3364], 'desoxyepothilone': [3370], 'B': [3371, 3773, 3782], 'resistant': [3372], 'leukemia': [3373], 'cells.Mol.': [3374], 'Proteomics.': [3376], '(M111.009001)Abstract': [3379], 'labeled': [3390, 4039], 'aminoxyTMT6': [3392, 3933, 4041], 'reagent': [3393, 3934, 4014], '(Thermo': [3394, 3935], 'Scientific)': [3396, 4059], 'analyzed': [3398, 4034], 'LC-ESI': [3400, 4036], 'MS,': [3401], 'according': [3402], 'procedures': [3405], '(35Kizuka': [3406], 'Ren': [3418], 'C.T.': [3419], 'alkynyl-fucose': [3427], 'halts': [3428], 'hepatoma': [3429], 'invasion': [3433], 'inhibiting': [3435], 'GDP-fucose-synthesizing': [3436], 'FX,': [3438], 'TSTA3.Cell': [3439], '24:': [3443], '1467-1478Abstract': [3444], '(38)': [3452], '36Nakano': [3455], 'Ito': [3459], 'Kitada': [3461], 'Hijioka': [3463], 'Kasahara': [3465], 'Tajiri': [3467], 'Wada': [3469], 'Site-specific': [3475], 'haptoglobin': [3480], 'sera': [3482], 'patients': [3484], 'novel': [3489], 'approach': [3490], 'markers.Int.': [3496], '2008;': [3499], '122:': [3500], '2301-2309Crossref': [3501], '(123)': [3504], 'follows.': [3510], 'brains': [3512], '(30': [3513], 'mg)': [3514], 'crushed': [3516], '2': [3518, 3577, 3656, 3690], 'ml': [3519, 3578, 3673, 3771], 'homogenization': [3521], 'buffer': [3522], '(50': [3523, 3581, 3917], 'mm': [3524, 3532, 3582, 3851, 4030, 4052, 4086, 4095], 'Tris-HCl,': [3525, 3583], 'pH': [3526, 3584, 3854], '7.4,': [3527, 3585], '0.1': [3528, 3586], 'm': [3529, 3587, 3703], 'NaCl,': [3530], '1': [3531, 3672, 3733, 3741, 3784, 4051], 'EDTA': [3533], 'protease': [3535], 'inhibitor': [3536], 'mixture': [3537], '(Roche,': [3538], 'Basel,': [3539], 'Switzerland))': [3540], 'Dounce': [3543], 'tissue': [3544], 'grinder': [3545], 'homogenized': [3548], 'polytron': [3551], 'homogenizer,': [3552], 'centrifugation': [3555, 3650, 3684], '760': [3557], '×': [3558, 3594, 3653, 3687, 3709, 3840, 4054], 'g': [3559, 3595, 3654, 3688], '20': [3561, 3643, 3832, 3850, 4026], 'min': [3562, 3598, 3636, 3734, 3742, 3754, 3833, 3898, 3955, 4004], '4': [3564, 3600, 3710, 3724], 'remove': [3567], 'nuclei': [3568], 'unbroken': [3570], 'supernatant': [3573], 'diluted': [3575], 'Tris-buffer': [3580, 3621], 'NaCl)': [3588], 'ultracentrifuged': [3591], '120,000': [3593], '80': [3597], '°C.': [3601], 'pellet': [3604], 'suspended': [3606], '100': [3608, 3819, 3985, 4055], 'μl': [3609, 3618, 3700, 3708, 3762, 3820, 3839, 3848, 3879, 3918, 3942, 3965, 3986, 4027], 'Tris-buffer,': [3612], '400': [3617], 'containing': [3622], '1%': [3623, 3822], 'Triton': [3624], 'X-114': [3625], 'pipetting.': [3627], 'lysate': [3629], 'incubated': [3631, 3866, 3883], 'ice': [3633], '37': [3640, 3868, 3885], 'min,': [3644, 3691, 3785, 3872, 4084, 4089, 4098], 'phase': [3647, 3661, 3668], 'partitioning': [3648], '1940': [3652, 3686], 'min.': [3657, 3980], 'upper': [3659], 'aqueous': [3660], 'removed,': [3663], 'detergent': [3667], 'mixed': [3670], 'ice-cold': [3675], 'acetone': [3676, 3989], 'kept': [3678], '−25': [3680], 'overnight.': [3682, 3887], 'After': [3683, 3717, 3778, 3959, 3981], 'precipitated': [3693], 'dissolved': [3697, 4024], '11': [3699], '8': [3702], 'Urea': [3704], 'spotted': [3706], '(2.5': [3707], 'times)': [3711], 'onto': [3712], 'an': [3713, 4061], 'ethanol-pretreated': [3714], 'PVDF': [3715], 'membrane.': [3716], 'drying': [3718], 'room': [3720, 3791, 3957, 4000], 'temperature': [3721, 3792, 4001], '>': [3723, 3794], 'h,': [3725], 'washed': [3729, 3835, 3914], 'ethanol': [3731], 'once': [3735], 'three': [3743], 'times.': [3744], '5': [3753, 3841], 'Direct': [3756, 3766], 'Blue': [3757, 3767], '71': [3758], '(Sigma': [3759], 'Aldrich)': [3760], '(800': [3761], 'solution': [3763, 3772, 3781, 3990], '(0.1%': [3765], '71)': [3768], '(acetic': [3774], 'acid/ethanol/water': [3775], '=': [3776], '1:4:5)).': [3777], 'destaining': [3779], 'dried': [3789, 3928], 'h.': [3796], 'spots': [3799, 3815, 3864], 'excised': [3801], 'placed': [3806], 'well': [3809, 3861, 3912], '96-well': [3812, 3894], 'plate.': [3813], 'covered': [3817], '(w/v)': [3823], 'poly(vinylpyrrolidone)': [3824], '40,000': [3825], '50%': [3827], '(v/v)': [3828, 4091, 4100], 'methanol,': [3829, 3945], 'agitated': [3830], '(100': [3838], 'times).': [3842], 'PNGase': [3843], 'F': [3844], '(2U': [3845], 'phosphate': [3852], 'buffer,': [3853], '7.3,': [3855], 'Roche)': [3856], 'added': [3858, 3970, 3992], '15': [3871, 3954, 3979, 4003], 'samples': [3889, 4021], 'sonicated': [3891], '(in': [3892], 'plate)': [3895], '(20': [3903], 'μl)': [3904], 'transferred': [3906], '1.5-ml': [3908], 'polypropylene': [3909], 'tubes.': [3910], 'twice),': [3919], 'washings': [3922], 'combined': [3924], 'evaporated.': [3926], 'reacted': [3931], '0.02': [3938], 'mg': [3939], '200': [3941, 3964], '95%': [3944, 3967], '0.1%': [3946], 'acetic': [3947], 'solution)': [3949], 'continuous': [3951, 4006], 'shaking': [3952, 3977], 'temperature.': [3958], 'evaporating': [3960, 3982], 'reaction': [3962], 'solution,': [3963], 'methanol': [3968], 'samples,': [3973, 3984, 3995], 'incubation': [3998], 'shaking.': [4007], 'sample': [4009], 'evaporated,': [4011], 'excess': [4013], 'removed': [4016], 'Sepharose': [4018], 'CL4B.': [4019], 'dried,': [4023], 'ammonium': [4031], 'bicarbonate': [4032], 'MS/MS.': [4037], 'N-Glycans': [4038], 'separated': [4043], 'carbon': [4046], 'column': [4047], '(5': [4048], 'μm': [4049], 'HyperCarb,': [4050], 'I.D.': [4053], 'mm,': [4056], 'Accela': [4062], 'pump': [4064], '(flow': [4065], 'rate:': [4066], '50': [4067], 'μl/min)': [4068], 'following': [4071], 'gradient': [4072], 'conditions;': [4073], 'sequence': [4075], 'isocratic': [4077], 'segmented': [4080], 'linear': [4081], 'gradients:': [4082], '0–8': [4083], 'NH4HCO3;': [4087, 4096], '8–38': [4088], '9–22.5%': [4090], 'CH3CN': [4092, 4101], '38–73': [4097], '22.5–51.75%': [4099]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2966318873', 'counts_by_year': [{'year': 2024, 'cited_by_count': 22}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 17}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-24T12:18:22.952475', 'created_date': '2019-08-13'}
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