Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2965712243', 'doi': 'https://doi.org/10.4049/jimmunol.1900293', 'title': 'IRF7 Is Involved in Both STING and MAVS Mediating IFN-β Signaling in IRF3-Lacking Chickens', 'display_name': 'IRF7 Is Involved in Both STING and MAVS Mediating IFN-β Signaling in IRF3-Lacking Chickens', 'publication_year': 2019, 'publication_date': '2019-10-01', 'ids': {'openalex': 'https://openalex.org/W2965712243', 'doi': 'https://doi.org/10.4049/jimmunol.1900293', 'mag': '2965712243', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31366714'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1900293', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/203/7/1930.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jimmunol.org/content/jimmunol/203/7/1930.full.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081007687', 'display_name': 'Yuqiang Cheng', 'orcid': 'https://orcid.org/0000-0003-3388-1775'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuqiang Cheng', 'raw_affiliation_strings': ['*School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, People’s Republic of China; and'], 'affiliations': [{'raw_affiliation_string': '*School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, People’s Republic of China; and', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101060629', 'display_name': 'Wenxian Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenxian Zhu', 'raw_affiliation_strings': ['*School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, People’s Republic of China; and'], 'affiliations': [{'raw_affiliation_string': '*School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, People’s Republic of China; and', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065570155', 'display_name': 'Chan Ding', 'orcid': 'https://orcid.org/0000-0003-0216-2129'}, 'institutions': [{'id': 'https://openalex.org/I4210098832', 'display_name': 'Shanghai Veterinary Research Institute', 'ror': 'https://ror.org/00yw25n09', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210098832', 'https://openalex.org/I4210127390', 'https://openalex.org/I4210138501', 'https://openalex.org/I4210151987']}, {'id': 'https://openalex.org/I4210138501', 'display_name': 'Chinese Academy of Agricultural Sciences', 'ror': 'https://ror.org/0313jb750', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I4210127390', 'https://openalex.org/I4210138501', 'https://openalex.org/I4210151987']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chan Ding', 'raw_affiliation_strings': ["†Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "†Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210098832', 'https://openalex.org/I4210138501']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014955507', 'display_name': 'Qiaona Niu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiaona Niu', 'raw_affiliation_strings': ['*School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, People’s Republic of China; and'], 'affiliations': [{'raw_affiliation_string': '*School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, People’s Republic of China; and', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029416150', 'display_name': 'Hengan Wang', 'orcid': 'https://orcid.org/0000-0002-8344-2482'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hengan Wang', 'raw_affiliation_strings': ['*School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, People’s Republic of China; and'], 'affiliations': [{'raw_affiliation_string': '*School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, People’s Republic of China; and', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102924684', 'display_name': 'Yaxian Yan', 'orcid': 'https://orcid.org/0000-0002-7192-9306'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yaxian Yan', 'raw_affiliation_strings': ['*School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, People’s Republic of China; and'], 'affiliations': [{'raw_affiliation_string': '*School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, People’s Republic of China; and', 'institution_ids': ['https://openalex.org/I183067930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5025696708', 'display_name': 'Jianhe Sun', 'orcid': 'https://orcid.org/0000-0002-4005-6071'}, 'institutions': [{'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Jianhe Sun', 'raw_affiliation_strings': ['*School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, People’s Republic of China; and'], 'affiliations': [{'raw_affiliation_string': '*School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, People’s Republic of China; and', 'institution_ids': ['https://openalex.org/I183067930']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5102924684', 'https://openalex.org/A5025696708'], 'corresponding_institution_ids': ['https://openalex.org/I183067930', 'https://openalex.org/I183067930'], 'apc_list': None, 'apc_paid': None, 'fwci': 4.133, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 55, 'citation_normalized_percentile': {'value': 0.999922, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '203', 'issue': '7', 'first_page': '1930', 'last_page': '1942'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11668', 'display_name': 'Innate Immunity to Viral Infection', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11668', 'display_name': 'Innate Immunity to Viral Infection', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12047', 'display_name': 'Viral Hemorrhagic Fevers and Zoonotic Infections', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Innate Immune Recognition and Signaling Pathways', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/irf7', 'display_name': 'IRF7', 'score': 0.9077884}, {'id': 'https://openalex.org/keywords/irf3', 'display_name': 'IRF3', 'score': 0.90176857}, {'id': 'https://openalex.org/keywords/interferon-signaling', 'display_name': 'Interferon Signaling', 'score': 0.487699}, {'id': 'https://openalex.org/keywords/sting', 'display_name': 'Sting', 'score': 0.45596784}], 'concepts': [{'id': 'https://openalex.org/C2776966659', 'wikidata': 'https://www.wikidata.org/wiki/Q18028003', 'display_name': 'IRF7', 'level': 4, 'score': 0.9077884}, {'id': 'https://openalex.org/C2780209191', 'wikidata': 'https://www.wikidata.org/wiki/Q14914339', 'display_name': 'IRF3', 'level': 4, 'score': 0.90176857}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6793979}, {'id': 'https://openalex.org/C9173399', 'wikidata': 'https://www.wikidata.org/wiki/Q6046461', 'display_name': 'Interferon regulatory factors', 'level': 4, 'score': 0.6021251}, {'id': 'https://openalex.org/C6929976', 'wikidata': 'https://www.wikidata.org/wiki/Q3771881', 'display_name': 'Regulator', 'level': 3, 'score': 0.58894384}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.56271535}, {'id': 'https://openalex.org/C2779300339', 'wikidata': 'https://www.wikidata.org/wiki/Q7617409', 'display_name': 'Sting', 'level': 2, 'score': 0.45596784}, {'id': 'https://openalex.org/C2776178377', 'wikidata': 'https://www.wikidata.org/wiki/Q188269', 'display_name': 'Interferon', 'level': 2, 'score': 0.41329122}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.3916786}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.33323553}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.25853616}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.20605701}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C146978453', 'wikidata': 'https://www.wikidata.org/wiki/Q3798668', 'display_name': 'Aerospace engineering', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D030161', 'descriptor_name': 'Avian Proteins', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': True}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D050839', 'descriptor_name': 'Interferon Regulatory Factor-7', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D050835', 'descriptor_name': 'Interferon Regulatory Factors', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': True}, {'descriptor_ui': 'D016899', 'descriptor_name': 'Interferon-beta', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D020816', 'descriptor_name': 'Amino Acid Motifs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030161', 'descriptor_name': 'Avian Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D030161', 'descriptor_name': 'Avian Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002642', 'descriptor_name': 'Chick Embryo', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050839', 'descriptor_name': 'Interferon Regulatory Factor-7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050839', 'descriptor_name': 'Interferon Regulatory Factor-7', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050835', 'descriptor_name': 'Interferon Regulatory Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050835', 'descriptor_name': 'Interferon Regulatory Factors', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016899', 'descriptor_name': 'Interferon-beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016899', 'descriptor_name': 'Interferon-beta', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1900293', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/203/7/1930.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31366714', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1900293', 'pdf_url': 'https://www.jimmunol.org/content/jimmunol/203/7/1930.full.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1559117436', 'https://openalex.org/W1909271167', 'https://openalex.org/W1978090289', 'https://openalex.org/W1981274274', 'https://openalex.org/W1988997130', 'https://openalex.org/W2005884645', 'https://openalex.org/W2008500280', 'https://openalex.org/W2025633900', 'https://openalex.org/W2026134797', 'https://openalex.org/W2028792773', 'https://openalex.org/W2029440821', 'https://openalex.org/W2031182394', 'https://openalex.org/W2058210634', 'https://openalex.org/W2064569908', 'https://openalex.org/W2066680385', 'https://openalex.org/W2082870151', 'https://openalex.org/W2083147016', 'https://openalex.org/W2085192138', 'https://openalex.org/W2099457187', 'https://openalex.org/W2108399976', 'https://openalex.org/W2126982616', 'https://openalex.org/W2135143264', 'https://openalex.org/W2144652247', 'https://openalex.org/W2146706147', 'https://openalex.org/W2163362670', 'https://openalex.org/W2169933147', 'https://openalex.org/W2174729763', 'https://openalex.org/W2175593937', 'https://openalex.org/W2199261756', 'https://openalex.org/W2558035065', 'https://openalex.org/W2580190897', 'https://openalex.org/W2612990438', 'https://openalex.org/W2724982590', 'https://openalex.org/W2749555766', 'https://openalex.org/W2801310804', 'https://openalex.org/W2810732825', 'https://openalex.org/W2887637071', 'https://openalex.org/W2894378799', 'https://openalex.org/W2907374247'], 'related_works': ['https://openalex.org/W2927551315', 'https://openalex.org/W2913960606', 'https://openalex.org/W2855942143', 'https://openalex.org/W2789244789', 'https://openalex.org/W2251317463', 'https://openalex.org/W2160045547', 'https://openalex.org/W2159995523', 'https://openalex.org/W2097895173', 'https://openalex.org/W2093572401', 'https://openalex.org/W2087123554'], 'abstract_inverted_index': {'IFN': [0, 19, 41, 188, 224], 'regulatory': [1, 219], 'factor': [2], '(IRF)': [3], '3': [4], 'has': [5], 'been': [6], 'identified': [7], 'as': [8, 134, 136, 147], 'the': [9, 52, 63, 114, 162, 218, 222], 'most': [10, 64], 'critical': [11, 65], 'regulator': [12, 67], 'of': [13, 83, 116, 164, 204, 217, 221], 'both': [14, 92, 141, 193], 'RNA': [15, 107, 196], 'and': [16, 58, 96, 106, 143, 195, 213], 'DNA': [17, 105, 194], 'virus-induced': [18], 'production': [20], 'in': [21, 26, 31, 38, 43, 56, 68, 91, 102, 150, 180], 'mammals.': [22], 'However,': [23], 'ambiguity': [24], 'exists': [25], 'research': [27], 'on': [28], 'chicken': [29, 72, 93, 97, 124, 223], 'IRFs;': [30], 'particular': [32], 'IRF3': [33, 177], 'seems': [34], 'to': [35, 85, 104, 145, 185, 190, 192], 'be': [36], 'missing': [37, 179], 'chickens,': [39, 181], 'making': [40], 'regulation': [42, 101], 'chickens': [44, 57], 'unclear.': [45], 'In': [46, 171], 'this': [47], 'study,': [48], 'we': [49, 79, 157, 173, 200], 'comprehensively': [50], 'investigated': [51], 'potential': [53], 'IFN-related': [54], 'IRFs': [55], 'showed': [59], 'that': [60, 87, 123, 137, 159, 175], 'IRF7': [61, 73, 184], 'is': [62, 89, 127, 178], 'IFN-β': [66, 100], 'chickens.': [69], 'With': [70], 'a': [71, 81, 148, 167, 202], '(chIRF7)': [74], 'knockout': [75], 'DF-1': [76], 'cell': [77], 'line,': [78], 'conducted': [80], 'series': [82], 'experiments': [84], 'demonstrate': [86], 'chIRF7': [88, 117, 130, 142, 151, 165, 205], 'involved': [90], 'STING': [94], '(chSTING)-': [95], 'MAVS': [98], '(chMAVS)-mediated': [99], 'response': [103], 'viral': [108, 197], 'infections,': [109], 'respectively.': [110], 'We': [111, 121], 'further': [112], 'examined': [113], 'mechanisms': [115, 220], 'activation': [118, 131, 152, 163, 206], 'by': [119, 132, 153, 207], 'chSTING.': [120, 208], 'found': [122], 'TBK1': [125], '(chTBK1)': [126], 'indispensable': [128], 'for': [129], 'chSTING': [133, 138, 160], 'well': [135], 'interacts': [139], 'with': [140], 'chTBK1': [144], 'function': [146], 'scaffold': [149], 'chTBK1.': [154], 'More': [155], 'interestingly,': [156], 'discovered': [158], 'mediates': [161], 'through': [166], 'conserved': [168], 'SLQxSyS': [169], 'motif.': [170], 'short,': [172], 'confirmed': [174], 'although': [176], 'they': [182], 'employ': [183], 'reconstitute': [186], 'corresponding': [187], 'signaling': [189], 'respond': [191], 'infections.': [198], 'Additionally,': [199], 'uncovered': [201], 'mechanism': [203], 'The': [209], 'results': [210], 'will': [211], 'enrich': [212], 'deepen': [214], 'our': [215], 'understanding': [216], 'system.': [225]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2965712243', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-09-01T07:56:19.729779', 'created_date': '2019-08-13'}