Publication Information

{'id': 'https://openalex.org/W2964010750', 'doi': 'https://doi.org/10.1194/jlr.m094607', 'title': 'Efficient reabsorption of transintestinally excreted cholesterol is a strong determinant for cholesterol disposal in mice', 'display_name': 'Efficient reabsorption of transintestinally excreted cholesterol is a strong determinant for cholesterol disposal in mice', 'publication_year': 2019, 'publication_date': '2019-07-20', 'ids': {'openalex': 'https://openalex.org/W2964010750', 'doi': 'https://doi.org/10.1194/jlr.m094607', 'mag': '2964010750', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31324653', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6718438'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1194/jlr.m094607', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S11400418', 'display_name': 'Journal of Lipid Research', 'issn_l': '0022-2275', 'issn': ['0022-2275', '1539-7262'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1194/jlr.m094607', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046477548', 'display_name': 'Ivo P. van de Peppel', 'orcid': 'https://orcid.org/0000-0002-6268-3404'}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ivo P. van de Peppel', 'raw_affiliation_strings': ['Section of Molecular Metabolism and Nutrition, Department of Pediatrics,University of Groningen, University Medical Center Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Section of Molecular Metabolism and Nutrition, Department of Pediatrics,University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024198672', 'display_name': 'Anna Bertolini', 'orcid': 'https://orcid.org/0000-0002-1460-8143'}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Anna Bertolini', 'raw_affiliation_strings': ['Section of Molecular Metabolism and Nutrition, Department of Pediatrics,University of Groningen, University Medical Center Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Section of Molecular Metabolism and Nutrition, Department of Pediatrics,University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045355558', 'display_name': 'Theo H. van Dijk', 'orcid': 'https://orcid.org/0000-0003-2713-049X'}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Theo H. van Dijk', 'raw_affiliation_strings': ['Department of Laboratory Medicine University of Groningen, University Medical Center Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Laboratory Medicine University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003115146', 'display_name': 'Albert K. Groen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}, {'id': 'https://openalex.org/I2802928900', 'display_name': 'Academic Medical Center', 'ror': 'https://ror.org/03t4gr691', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802928900', 'https://openalex.org/I4210151833']}, {'id': 'https://openalex.org/I887064364', 'display_name': 'University of Amsterdam', 'ror': 'https://ror.org/04dkp9463', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I887064364']}, {'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Albert K. Groen', 'raw_affiliation_strings': ['Laboratory of Experimental Vascular Medicine University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands', 'Section of Molecular Metabolism and Nutrition, Department of Pediatrics,University of Groningen, University Medical Center Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Section of Molecular Metabolism and Nutrition, Department of Pediatrics,University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I169381384', 'https://openalex.org/I1334415907']}, {'raw_affiliation_string': 'Laboratory of Experimental Vascular Medicine University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2802928900', 'https://openalex.org/I887064364']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016852056', 'display_name': 'Johan W. Jonker', 'orcid': 'https://orcid.org/0000-0002-3919-5437'}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Johan W. Jonker', 'raw_affiliation_strings': ['Section of Molecular Metabolism and Nutrition, Department of Pediatrics,University of Groningen, University Medical Center Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Section of Molecular Metabolism and Nutrition, Department of Pediatrics,University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5031718124', 'display_name': 'Henkjan J. Verkade', 'orcid': 'https://orcid.org/0000-0002-7034-2861'}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Henkjan J. Verkade', 'raw_affiliation_strings': ['Section of Molecular Metabolism and Nutrition, Department of Pediatrics,University of Groningen, University Medical Center Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Section of Molecular Metabolism and Nutrition, Department of Pediatrics,University of Groningen, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5016852056', 'https://openalex.org/A5031718124'], 'corresponding_institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384', 'https://openalex.org/I1334415907', 'https://openalex.org/I169381384'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.65, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.877226, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '60', 'issue': '9', 'first_page': '1562', 'last_page': '1572'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11618', 'display_name': 'Cholesterol and Lipid Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11618', 'display_name': 'Cholesterol and Lipid Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10394', 'display_name': 'Lipoproteins and Cardiovascular Health', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9873, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C56906281', 'wikidata': 'https://www.wikidata.org/wiki/Q4391435', 'display_name': 'Reabsorption', 'level': 3, 'score': 0.7839387}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.7618536}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5536931}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4652973}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4344222}, {'id': 'https://openalex.org/C2780026642', 'wikidata': 'https://www.wikidata.org/wiki/Q40924', 'display_name': 'Urine', 'level': 2, 'score': 0.4126575}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30505484}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2558443}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.19420242}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.17604172}], 'mesh': [{'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001692', 'descriptor_name': 'Biological Transport', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000069438', 'descriptor_name': 'Ezetimibe', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007408', 'descriptor_name': 'Intestinal Absorption', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029363', 'descriptor_name': 'Organic Anion Transporters, Sodium-Dependent', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D027981', 'descriptor_name': 'Symporters', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1194/jlr.m094607', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S11400418', 'display_name': 'Journal of Lipid Research', 'issn_l': '0022-2275', 'issn': ['0022-2275', '1539-7262'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://pure.rug.nl/ws/files/97541265/Efficient_reabsorption_of_transintestinally_excreted.pdf', 'pdf_url': 'https://pure.rug.nl/ws/files/97541265/Efficient_reabsorption_of_transintestinally_excreted.pdf', 'source': {'id': 'https://openalex.org/S4306400420', 'display_name': 'University of Groningen research database (University of Groningen / Centre for Information Technology)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I169381384', 'host_organization_name': 'University of Groningen', 'host_organization_lineage': ['https://openalex.org/I169381384'], 'host_organization_lineage_names': ['University of Groningen'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718438', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://pure.rug.nl/ws/files/94519137/Efficient_reabsorption_of_transintestinally_excreted_cholesterol_is_a_strong_determinant_for_cholesterol_disposal_in_mice.pdf', 'pdf_url': 'https://pure.rug.nl/ws/files/94519137/Efficient_reabsorption_of_transintestinally_excreted_cholesterol_is_a_strong_determinant_for_cholesterol_disposal_in_mice.pdf', 'source': {'id': 'https://openalex.org/S4306400420', 'display_name': 'University of Groningen research database (University of Groningen / Centre for Information Technology)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I169381384', 'host_organization_name': 'University of Groningen', 'host_organization_lineage': ['https://openalex.org/I169381384'], 'host_organization_lineage_names': ['University of Groningen'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://research.rug.nl/en/publications/fabe643b-ba46-4c13-9b93-fc735ff26263', 'pdf_url': 'https://research.rug.nl/files/94519137/Efficient_reabsorption_of_transintestinally_excreted_cholesterol_is_a_strong_determinant_for_cholesterol_disposal_in_mice.pdf', 'source': {'id': 'https://openalex.org/S4306401843', 'display_name': 'Data Archiving and Networked Services (DANS)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1322597698', 'host_organization_name': 'Royal Netherlands Academy of Arts and Sciences', 'host_organization_lineage': ['https://openalex.org/I1322597698'], 'host_organization_lineage_names': ['Royal Netherlands Academy of Arts and Sciences'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31324653', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1194/jlr.m094607', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S11400418', 'display_name': 'Journal of Lipid Research', 'issn_l': '0022-2275', 'issn': ['0022-2275', '1539-7262'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320320870', 'funder_display_name': 'European Foundation for the Study of Diabetes', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1520609538', 'https://openalex.org/W1544538842', 'https://openalex.org/W1554164117', 'https://openalex.org/W1943976550', 'https://openalex.org/W1972407879', 'https://openalex.org/W1975740583', 'https://openalex.org/W1977386560', 'https://openalex.org/W1979410546', 'https://openalex.org/W1989086831', 'https://openalex.org/W1993940832', 'https://openalex.org/W1994757060', 'https://openalex.org/W1995905776', 'https://openalex.org/W2016152013', 'https://openalex.org/W2016285095', 'https://openalex.org/W2024039041', 'https://openalex.org/W2036412628', 'https://openalex.org/W2051117863', 'https://openalex.org/W2060057992', 'https://openalex.org/W2065895117', 'https://openalex.org/W2072152755', 'https://openalex.org/W2094929865', 'https://openalex.org/W2114000516', 'https://openalex.org/W2114639683', 'https://openalex.org/W2117616183', 'https://openalex.org/W2117901133', 'https://openalex.org/W2118433395', 'https://openalex.org/W2123936150', 'https://openalex.org/W2128597483', 'https://openalex.org/W2130242746', 'https://openalex.org/W2134358461', 'https://openalex.org/W2134394576', 'https://openalex.org/W2136546224', 'https://openalex.org/W2152311269', 'https://openalex.org/W2156911716', 'https://openalex.org/W2168450753', 'https://openalex.org/W2169523655', 'https://openalex.org/W2171795832', 'https://openalex.org/W2225385710', 'https://openalex.org/W2300552860', 'https://openalex.org/W2335309900', 'https://openalex.org/W2422869189', 'https://openalex.org/W2485417128', 'https://openalex.org/W2530399990', 'https://openalex.org/W2548652959', 'https://openalex.org/W2560300110', 'https://openalex.org/W2568717171', 'https://openalex.org/W2591645344', 'https://openalex.org/W2591878967', 'https://openalex.org/W2593823350', 'https://openalex.org/W2768114183', 'https://openalex.org/W2778101470', 'https://openalex.org/W2797942262', 'https://openalex.org/W2891050158', 'https://openalex.org/W4231976278', 'https://openalex.org/W4256475235', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4391375266', 'https://openalex.org/W4312562162', 'https://openalex.org/W4205289363', 'https://openalex.org/W2748952813', 'https://openalex.org/W2461522526', 'https://openalex.org/W2364973402', 'https://openalex.org/W2123494603', 'https://openalex.org/W2088962229', 'https://openalex.org/W2064336948', 'https://openalex.org/W1496880727'], 'abstract_inverted_index': {'Transintestinal': [0, 202, 1992], 'cholesterol': [1, 10, 32, 45, 64, 98, 117, 144, 167, 188, 200, 203, 212, 234, 247, 266, 300, 319, 346, 369, 390, 402, 500, 627, 641, 741, 756, 773, 908, 911, 918, 926, 994, 1034, 1059, 1256, 1295, 1418, 1476, 1484, 1503, 1513, 1532, 1535, 1569, 1617, 1737, 1788, 1839, 1865, 1898, 1968, 1993, 2012, 2023, 2112, 2161, 2234, 2293, 2372, 2413, 2500, 2538, 2572, 2577, 2584, 2590, 2609, 2670, 2675, 2693, 2778, 2814, 2956, 2994, 3045, 3130, 3135, 3220, 3318, 3445, 3562, 3703, 4035, 4059, 4084, 4102, 4116, 4126, 4158, 4225, 4249], 'excretion': [2, 113, 204, 315, 893, 927, 995, 1025, 1501, 1514, 1689, 1738, 1797, 1840, 1907, 1994, 2192, 2294, 2336, 2452, 2501, 2547, 2908, 2957, 3003, 3046, 3088, 4081, 4117], '(TICE)': [3, 205], 'is': [4, 25, 37, 136, 206, 227, 239, 338, 427, 478, 850, 933, 1333, 1516, 1571, 1611, 2025, 2066, 2151, 2236, 2816, 3339, 3989], 'a': [5, 15, 149, 207, 217, 351, 523, 606, 699, 736, 788, 903, 1027, 1112, 1141, 1401, 1486, 1962, 2088, 2146, 2605, 2704, 2786, 3182, 3188, 3295, 3321, 3382, 3506, 3606, 3629, 3706, 3731, 3889, 3930, 3965, 3976, 4062, 4161, 4279], 'major': [6, 208, 1493], 'route': [7, 209], 'for': [8, 19, 210, 221, 416, 526, 545, 661, 723, 1371, 1410, 3252, 3281, 3360, 3595, 3653, 3725, 3914, 3919, 3940, 4042, 4107, 4267], 'eliminating': [9, 211], 'from': [11, 34, 54, 213, 236, 256, 501, 605, 772, 996, 1033, 1339, 1946, 2090, 2415, 2695, 3486, 3648, 3676, 3762, 4000, 4187, 4262], 'the': [12, 35, 40, 49, 76, 80, 141, 158, 164, 177, 185, 214, 237, 242, 251, 278, 282, 343, 360, 366, 379, 387, 448, 492, 497, 504, 646, 724, 733, 750, 775, 779, 785, 797, 800, 806, 831, 843, 854, 863, 876, 891, 915, 997, 1012, 1320, 1342, 1349, 1353, 1360, 1364, 1372, 1407, 1411, 1439, 1489, 1499, 1638, 1683, 1869, 1939, 2016, 2139, 2156, 2170, 2179, 2200, 2375, 2406, 2410, 2446, 2564, 2569, 2612, 2615, 2637, 2684, 2696, 2721, 2857, 2902, 3246, 3256, 3278, 3289, 3348, 3351, 3374, 3404, 3472, 3497, 3523, 3565, 3576, 3602, 3645, 3859, 3862, 3884, 3945, 3958, 4094, 4100, 4108, 4254, 4313], 'body': [13, 36, 215, 238, 734, 998, 3367, 3612], 'and': [14, 28, 92, 104, 114, 127, 216, 230, 294, 306, 316, 329, 412, 424, 431, 480, 486, 547, 567, 570, 597, 602, 726, 746, 757, 781, 790, 811, 839, 865, 897, 928, 932, 947, 1026, 1058, 1108, 1115, 1144, 1152, 1200, 1260, 1296, 1382, 1521, 1575, 1577, 1623, 1925, 1933, 2113, 2195, 2198, 2240, 2242, 2396, 2672, 2689, 2700, 2718, 2738, 2754, 2763, 2820, 2822, 3132, 3184, 3200, 3215, 3269, 3273, 3316, 3354, 3363, 3366, 3380, 3406, 3440, 3460, 3467, 3476, 3481, 3513, 3637, 3667, 3701, 3738, 3752, 3773, 3780, 3883, 3917, 3935, 3951, 4008, 4021, 4057, 4079, 4082, 4096, 4133, 4156, 4195, 4208, 4223, 4226, 4247, 4290, 4304, 4315], 'potential': [16, 218], 'therapeutic': [17, 219], 'target': [18, 220], 'hypercholesterolemia.': [20, 222], 'The': [21, 223, 442, 474, 629, 1099, 1315, 1599, 2167, 3192, 3336, 3517, 3620, 3849, 3893, 3925, 3986], 'underlying': [22, 224, 1602], 'mechanism,': [23, 225], 'however,': [24, 226], 'largely': [26, 137, 228, 339], 'unclear,': [27, 229], 'its': [29, 55, 231, 257, 425, 758, 3668], 'contribution': [30, 232, 2570], 'to': [31, 102, 148, 233, 304, 350, 408, 491, 554, 653, 842, 905, 938, 940, 974, 1077, 1149, 1470, 1498, 1527, 1792, 1902, 1966, 2087, 2092, 2153, 2163, 2403, 2542, 2682, 2998, 3157, 3162, 3198, 3347, 3489, 3582, 3610, 3975, 4006, 4098, 4193], 'disposal': [33, 235, 2694], 'obscured': [38, 240], 'by': [39, 71, 75, 241, 273, 277, 651, 761, 827, 853, 913, 1003, 1206, 1335, 1345, 1619, 1640, 1930, 2205, 2578, 2592, 2710, 2859, 3245, 3293, 3320, 3501, 3685, 3705, 3784, 3991, 4061, 4160], 'counteracting': [41, 243], 'process': [42, 244], 'of': [43, 51, 61, 79, 179, 187, 245, 253, 263, 281, 381, 389, 419, 444, 476, 494, 499, 595, 634, 702, 728, 808, 819, 847, 894, 1053, 1101, 1117, 1165, 1195, 1247, 1317, 1322, 1356, 1366, 1379, 1404, 1413, 1438, 1447, 1483, 1488, 1502, 1531, 1637, 1682, 1690, 1836, 1941, 2009, 2068, 2158, 2172, 2181, 2409, 2412, 2445, 2453, 2571, 2574, 2582, 2614, 2636, 2645, 2687, 2856, 2901, 2909, 3042, 3208, 3248, 3255, 3258, 3314, 3350, 3385, 3410, 3505, 3508, 3642, 3699, 3733, 3852, 3861, 3961, 4003, 4017, 4055, 4154, 4204, 4293], 'intestinal': [44, 63, 81, 116, 143, 246, 265, 283, 318, 345, 762, 820, 917, 1013, 1408, 1417, 1475, 1764, 1787, 1897, 2206, 2537, 2589, 2777, 2993, 3315, 3657, 3700, 3829, 4056, 4101, 4155], 'reabsorption.': [46, 248], 'To': [47, 249, 3154], 'determine': [48, 250, 2683], 'quantity': [50, 252], 'TICE': [52, 135, 193, 254, 337, 395, 1603, 1610, 1761, 1856, 1929, 2141, 2173, 2204, 2416], 'independent': [53, 255, 2067], 'reabsorption,': [56, 258, 1018], 'we': [57, 182, 259, 384, 2567, 2587, 2599, 2668, 2678, 3963], 'studied': [58, 260], 'two': [59, 261, 2580, 3745], 'models': [60, 159, 262, 361, 1085, 1157, 1861, 2008, 2581, 2681], 'decreased': [62, 264, 1402], 'absorption.': [65, 267, 2676], 'Cholesterol': [66, 268, 730, 1959, 3284, 4131, 4289], 'absorption': [67, 99, 269, 301, 807, 912, 1419, 1482, 2024, 2038], 'was': [68, 146, 153, 169, 270, 348, 355, 371, 1857, 3519, 3580, 3593, 3615, 3651, 3856, 3886, 3895, 3927, 4036, 4118, 4265, 4310, 4319], 'inhibited': [69, 271, 2588], 'either': [70, 173, 272, 375], 'ezetimibe': [72, 90, 274, 292, 2688, 3231], 'or,': [73, 275], 'indirectly,': [74, 276], 'genetic': [77, 279, 485], 'inactivation': [78, 94, 280, 296, 1479], 'apical': [82, 284, 832, 1167, 1249, 1285], 'sodium-dependent': [83, 285, 833], 'bile': [84, 286, 766, 798, 834, 1056, 1102, 1171, 1197, 1251, 1288, 1386, 1441, 1448, 2639, 2646, 2752, 3592, 3830, 3869, 4004], 'acid': [85, 287, 835, 1050, 1057, 1103, 1172, 1198, 1252, 1289, 1387, 1442, 2640, 2753, 3831], 'transporter': [86, 288, 836, 919, 1253, 1290, 1443, 2641], '(ASBT;': [87, 289, 837], 'SLC10A2).': [88, 290], 'Both': [89, 291, 3778], 'treatment': [91, 293, 727], 'Asbt': [93, 295], 'virtually': [95, 297], 'abrogated': [96, 298], 'fractional': [97, 299, 2022, 2674], '(from': [100, 302], '46%': [101, 303], '4%': [103, 305], '6%,': [105, 307], 'respectively).': [106, 308], 'In': [107, 139, 309, 341, 2007, 2563, 2665], 'both': [108, 310, 484, 862, 895, 1518, 2040, 2666, 2680], 'models,': [109, 311, 2667], 'fecal': [110, 312, 892, 925, 1023, 1330, 1374, 1500, 1580, 1794, 1904, 1947, 2057, 2115, 2164, 2190, 2245, 2544, 2825, 3000, 3134, 3672, 3681], 'neutral': [111, 313, 753, 1581, 1645, 1795, 1905, 2058, 2246, 2334, 2545, 2826, 2864, 3001, 3086], 'sterol': [112, 314, 1582, 1646, 1796, 1906, 2059, 2070, 2116, 2247, 2335, 2546, 2734, 2755, 2827, 2865, 3002, 3087], 'net': [115, 142, 317, 344], 'balance': [118, 145, 320, 347, 739, 3323, 3563, 3708, 4064, 4103, 4163], 'were': [119, 160, 321, 362, 2707, 2780, 3172, 3175, 3243, 3262, 3286, 3358, 3369, 3376, 3428, 3462, 3479, 3483, 3499, 3623, 3659, 3674, 3723, 3742, 3760, 3782, 3871, 3878, 3904, 3947, 3998, 4086, 4136, 4177, 4185, 4229, 4250, 4273, 4295], 'considerably': [120, 322], 'higher': [121, 323], 'than': [122, 324], 'in': [123, 198, 325, 400, 421, 429, 447, 503, 732, 774, 784, 805, 861, 875, 1021, 1030, 1083, 1089, 1154, 1176, 1203, 1258, 1299, 1359, 1384, 1400, 1406, 1450, 1468, 1519, 1573, 1648, 1739, 1763, 1798, 1841, 1860, 1908, 1938, 1951, 1995, 2039, 2072, 2118, 2142, 2238, 2295, 2341, 2374, 2502, 2548, 2608, 2648, 2733, 2751, 2757, 2818, 2867, 2958, 3004, 3047, 3093, 3137, 3178, 3181, 3264, 3288, 3341, 3395, 3421, 3522, 3555, 3575, 3598, 3605, 3639, 3662, 3671, 3906, 3911, 4093, 4140, 4180, 4190, 4312], 'control': [124, 326], 'mice': [125, 327, 1205, 1520, 1574, 2239, 2602, 2699, 2740, 2760, 2784, 2819, 3168, 3193, 3375, 3452, 3498, 3558, 3603, 4264], '(5-': [126, 328], '7-fold,': [128, 330], 'respectively),': [129, 331], 'suggesting': [130, 162, 332, 364], 'that,': [131, 333], 'under': [132, 172, 334, 374, 3897], 'physiological': [133, 335, 815], 'conditions,': [134, 336, 816, 2389], 'reabsorbed.': [138, 340], 'addition,': [140, 342], 'increased': [147, 156, 349, 358, 1022, 1336, 1373, 2114, 2189], 'similar': [150, 352, 1142, 4087], 'extent': [151, 353], 'but': [152, 354, 686, 1168], 'not': [154, 356, 1169, 1605, 2418, 3560], 'further': [155, 357, 941], 'when': [157, 359], 'combined,': [161, 363], 'that': [163, 184, 365, 386, 638, 1496, 2169, 2603], 'effect': [165, 367, 2686], 'on': [166, 368, 600, 1055, 1105, 1616, 2178, 2202, 2338, 2692, 2703, 2776, 2782, 3090, 4278], 'reabsorption': [168, 370, 1321, 2157, 2171, 2411, 3832], 'already': [170, 372], 'maximal': [171, 373], 'condition': [174, 376], 'alone.': [175, 377], 'On': [176, 378, 3371, 3494], 'basis': [178, 380, 2180], 'these': [180, 382, 2143], 'findings,': [181, 383], 'hypothesize': [183, 385], 'inhibition': [186, 388, 1138, 1316, 2691], '(re)absorption': [189, 391, 2573, 2591, 2610], 'combined': [190, 392, 2679, 2685], 'with': [191, 393, 1862, 2028, 2034, 2183, 2785, 3187, 3228, 3266, 3378, 3601, 3625, 3730, 3747, 3754, 3764, 3769, 3775, 3874, 4039, 4321], 'stimulating': [192, 394], 'will': [194, 396], 'be': [195, 397, 1001, 2176, 3155], 'most': [196, 398, 630, 2774], 'effective': [197, 399, 717], 'increasing': [199, 401, 428, 556], 'disposal.': [201, 403], 'Atherosclerosis,': [404], 'which': [405, 1332, 1472, 1641, 2188, 2595, 2860], 'can': [406, 489, 999], 'lead': [407], 'coronary': [409, 979], 'artery': [410], 'disease': [411, 446, 648], 'cerebrovascular': [413], 'accidents,': [414], 'accounts': [415], 'approximately': [417], '50%': [418, 3909], 'deaths': [420], 'Westernized': [422], 'countries,': [423], 'prevalence': [426], 'low-': [430, 2762], 'middle-income': [432], 'countries': [433], '(1Gersh': [434], 'B.J.': [435], 'Sliwa': [436], 'K.': [437, 565, 1036, 1224, 1228, 1431, 1674, 1776, 1822, 1886, 2437, 2526, 2629, 2893, 2982, 3028], 'Mayosi': [438], 'B.M.': [439], 'Yusuf': [440], 'S.': [441, 1038, 1040, 2362, 3801], 'epidemic': [443], 'cardiovascular': [445, 527, 647, 949], 'developing': [449], 'world:': [450], 'global': [451], 'implications.Eur.': [452], 'Heart': [453, 610], 'J.': [454, 667, 692, 706, 982, 1061, 1121, 1161, 1262, 1423, 1537, 1552, 1843, 2217, 2621, 2797, 3049, 3110, 4023, 4210], '2010;': [455, 1539, 2345, 3097], '31:': [456], '642-648Crossref': [457], 'PubMed': [458, 469, 514, 538, 577, 616, 671, 712, 885, 988, 1067, 1132, 1187, 1218, 1267, 1310, 1393, 1462, 1594, 1654, 1703, 1749, 1808, 1851, 1918, 1981, 2002, 2082, 2133, 2259, 2305, 2348, 2382, 2466, 2512, 2558, 2660, 2769, 2839, 2873, 2922, 2968, 3014, 3057, 3100, 3149, 3331, 3570, 3716, 3844, 4029, 4072, 4171, 4216], 'Scopus': [459, 470, 515, 539, 578, 617, 672, 886, 989, 1068, 1133, 1188, 1219, 1268, 1311, 1394, 1463, 1595, 1655, 1704, 1750, 1809, 1852, 1919, 1982, 2003, 2083, 2134, 2260, 2306, 2349, 2383, 2467, 2513, 2559, 2661, 2770, 2840, 2874, 2923, 2969, 3015, 3058, 3101, 3150, 3332, 3717, 3845, 4030, 4073, 4172, 4217], '(324)': [460], 'Google': [461, 472, 517, 541, 580, 619, 674, 713, 888, 991, 1070, 1135, 1190, 1221, 1270, 1313, 1396, 1465, 1542, 1597, 1657, 1706, 1752, 1811, 1854, 1921, 1984, 2005, 2085, 2136, 2262, 2308, 2351, 2385, 2469, 2515, 2561, 2663, 2772, 2842, 2876, 2925, 2971, 3017, 3060, 3103, 3152, 3334, 3571, 3719, 3847, 4032, 4075, 4174, 4219], 'Scholar,': [462, 518, 581, 1191, 1222, 1271, 1543, 1658, 1707, 1812, 1985, 2263, 2309, 2352, 2470, 2516, 2843, 2877, 2926, 2972, 3018, 3061, 3104], '2Lusis': [463], 'A.J.': [464, 509], 'Atherosclerosis.Nature.': [465, 510], '2000;': [466, 511, 574], '407:': [467, 512], '233-241Crossref': [468, 513], '(4668)': [471, 516], 'Scholar).': [473, 542, 675, 714, 889, 992, 1071, 1136, 1314, 1397, 1466, 1598, 1753, 1855, 1922, 2137, 2386, 2562, 2664, 3153, 3335, 3572, 3720, 3848, 4033, 4076, 4175, 4220], 'etiology': [475], 'atherosclerosis': [477, 495, 548, 1153, 1175, 1202, 1298], 'complex,': [479], 'risk': [481, 524, 649], 'factors': [482], 'are': [483, 636, 721, 770, 794, 822, 2730], 'environmental.': [487], 'Hypercholesterolemia': [488], 'contribute': [490], 'development': [493], 'via': [496, 749, 796, 830, 1140, 1533, 3617, 3833], 'accumulation': [498], 'LDLs': [502], 'arterial': [505], 'vessel': [506], 'wall': [507], '(2Lusis': [508], '3Nelson': [519], 'R.H.': [520], 'Hyperlipidemia': [521], 'as': [522, 621, 623, 752, 765, 902, 935, 1086, 1088, 1511, 1868, 2015, 2149, 3206, 3301, 3529, 3683, 3786, 3858, 4120, 4138], 'factor': [525], 'disease.Prim.': [528], 'Care.': [529], '2013;': [530, 882, 1179], '40:': [531, 1065], '195-211Abstract': [532], 'Full': [533, 535, 1127, 1129, 1182, 1184, 1213, 1215, 1305, 1307, 1457, 1459, 1589, 1591, 1698, 1700, 1744, 1746, 1803, 1805, 1913, 1915, 1976, 1978, 2077, 2079, 2128, 2130, 2254, 2256, 2300, 2302, 2461, 2463, 2507, 2509, 2553, 2555, 2655, 2657, 2834, 2836, 2917, 2919, 2963, 2965, 3009, 3011, 3144, 3146, 3839, 3841], 'Text': [534, 536, 1128, 1130, 1183, 1185, 1214, 1216, 1306, 1308, 1458, 1460, 1590, 1592, 1699, 1701, 1745, 1747, 1804, 1806, 1914, 1916, 1977, 1979, 2078, 2080, 2129, 2131, 2255, 2257, 2301, 2303, 2462, 2464, 2508, 2510, 2554, 2556, 2656, 2658, 2835, 2837, 2918, 2920, 2964, 2966, 3010, 3012, 3145, 3147, 3840, 3842], 'PDF': [537, 1131, 1186, 1217, 1309, 1461, 1593, 1702, 1748, 1807, 1917, 1980, 2081, 2132, 2258, 2304, 2465, 2511, 2557, 2659, 2838, 2921, 2967, 3013, 3148, 3843], '(573)': [540], 'Treatment': [543], 'options': [544], 'hypercholesterolemia': [546, 1151], 'include': [549], 'lifestyle': [550], 'modifications': [551], '(e.g.,': [552], 'ceasing': [553], 'smoke,': [555], 'physical': [557], 'activity,': [558], 'improving': [559], 'diet': [560, 2392, 3280], 'quality)': [561], '(4Hata': [562], 'Y.': [563, 1558, 1630, 2223, 2358, 2803, 2849], 'Nakajima': [564], 'Life-style': [566], 'serum': [568, 1255], 'lipids': [569, 601, 3997, 4184], 'lipoproteins.J.': [571], 'Atheroscler.': [572], 'Thromb.': [573], '7:': [575], '177-197Crossref': [576], '(82)': [579, 2135, 3151], '5Gepner': [582], 'A.D.': [583], 'Piper': [584], 'M.E.': [585], 'Johnson': [586], 'H.M.': [587, 3549], 'Fiore': [588], 'M.C.': [589], 'Baker': [590], 'T.B.': [591], 'Stein': [592], 'J.H.': [593], 'Effects': [594], 'smoking': [596, 598], 'cessation': [599], 'lipoproteins:': [603], 'outcomes': [604, 950], 'randomized': [607, 1118], 'clinical': [608], 'trial.Am.': [609], 'J': [611], '.': [612, 708, 881, 984, 1123, 1585, 1847, 1972, 2250, 2344, 2830, 3053, 3096], '2011;': [613, 1651, 2870], '161:': [614], '145-151Crossref': [615], '(153)': [618], 'Scholar),': [620, 2773], 'well': [622, 1087], 'drugs': [624, 635, 660], 'targeted': [625], 'at': [626, 1612, 2720, 3430, 3728, 3880, 3899, 3922, 3937], 'metabolism.': [628], 'widely': [631], 'prescribed': [632], 'class': [633], 'statins': [637, 644, 939], 'inhibit': [639, 3827], 'hepatic': [640, 929, 1337, 3129], 'synthesis.': [642], 'Unfortunately,': [643], 'reduce': [645, 942, 1150], 'only': [650, 1936, 3166], '15%': [652, 4188], '37%': [654], '(6Ahn': [655], 'C.H.': [656], 'Choi': [657], 'S.H.': [658], 'New': [659], 'treating': [662], 'dyslipidemia:': [663], 'beyond': [664, 2193], 'statins.Diabetes': [665], 'Metab.': [666], '2015;': [668, 985, 3836], '39:': [669], '87-94Crossref': [670], '(34)': [673], 'Novel': [676, 1244], 'proprotein': [677], 'convertase': [678], 'subtilsinkexin': [679], 'type': [680], '9': [681], 'inhibitors': [682], 'show': [683], 'promising': [684], 'results': [685, 1399, 3161], 'also': [687, 1000, 1146, 1858], 'limitations': [688], '(7Chaudhary': [689], 'R.': [690, 1564, 1672, 1727, 2047, 2049, 2097, 2101, 2229, 2283, 2435, 2490, 2809, 2891, 2946, 3545, 3803, 3807], 'Garg': [691], 'Shah': [693], 'N.': [694, 1433, 2631], 'Sumner': [695], 'A.': [696, 958, 1725, 2281, 2488, 2712, 2944, 3812, 3814], 'PCSK9': [697], 'inhibitors:': [698], 'new': [700, 1963], 'era': [701], 'lipid': [703, 1106, 3553, 4019, 4206], 'lowering': [704, 1416], 'therapy.World': [705], 'Cardiol': [707, 1122], '2017;': [709, 1124, 1390, 1741, 2297, 2504, 2960], '9:': [710], '76-91Crossref': [711], 'Therefore,': [715, 1467, 2138], 'more': [716], 'or': [718, 764, 1871, 3229, 3854], 'adjunct': [719, 936], 'treatments': [720], 'needed': [722], 'prevention': [725], 'atherosclerosis.': [729], 'homeostasis': [731], 'encompasses': [735], 'highly': [737], 'regulated': [738, 852], 'between': [740, 2736], 'intake,': [742], 'de': [743, 1235, 1550, 2215, 2795, 3108], 'novo': [744], 'synthesis,': [745], 'disposal,': [747], 'mainly': [748, 826], 'feces': [751, 3357, 3482, 3722, 3763], 'sterols': [754, 1643, 2862], '(NSs;': [755], 'metabolites': [759, 3670], 'produced': [760], 'microbiota)': [763], 'acids': [767, 1449, 2647], '(BAs).': [768], 'BAs': [769, 793, 821, 898, 1010, 1357, 1405, 3759, 3781, 3853], 'synthetized': [771], 'liver,': [776], 'secreted': [777, 795], 'into': [778, 799, 3888, 3929, 3949], 'bile,': [780], 'predominantly': [782], 'stored': [783], 'gallbladder.': [786], 'Following': [787], 'meal': [789], 'gallbladder': [791, 3518], 'emptying,': [792], 'duodenum,': [801], 'where': [802], 'they': [803], 'aid': [804], 'fat,': [809], 'cholesterol,': [810, 1414, 4246], 'fat-soluble': [812], 'vitamins.': [813], 'Under': [814], 'about': [817], '95%': [818], 'reabsorbed': [823], 'each': [824, 3649, 4268], 'cycle,': [825], 'ileal': [828, 1166, 1196, 1248, 1284, 1380, 1440, 2638], 'enterocytes': [829], 'SLC10A2),': [838], 'transported': [840], 'back': [841], 'liver.': [844], 'This': [845, 1398, 1508, 1923], 'mechanism': [846, 1143, 1601, 1639, 1965, 2858], 'enterohepatic': [848, 877, 1343, 1361, 1445, 2643], 'circulation': [849, 1344], 'tightly': [851], 'BA-activated': [855], 'nuclear': [856], 'farnesoid': [857, 1732, 2288, 2495, 2951], 'X': [858, 1685, 1733, 2063, 2289, 2448, 2496, 2904, 2952], 'receptor': [859, 1686, 1734, 2064, 2290, 2449, 2497, 2905, 2953], '(FXR)': [860], 'liver': [864, 1684, 2062, 2447, 2903, 4314], 'intestine': [866], '(8Matsubara': [867], 'T.': [868, 1159, 1241, 1243, 1560, 1720, 2045, 2225, 2276, 2354, 2364, 2366, 2483, 2805, 2939, 3798], 'Li': [869], 'F.': [870, 1628, 1680, 1783, 1832, 1893, 1956, 2055, 2109, 2326, 2443, 2533, 2847, 2899, 2989, 3038, 3078, 3533, 3820], 'Gonzalez': [871], 'F.J.': [872], 'FXR': [873, 2207, 2398], 'signaling': [874], 'system.Mol.': [878], 'Cell.': [879], 'Endocrinol': [880], '368:': [883], '17-29Crossref': [884], '(242)': [887], 'Inducing': [890], 'NSs': [896, 3665, 3741, 3779, 3855], 'has': [899, 1145, 1504, 1604, 2417], 'been': [900, 1075, 1147, 1506, 1606, 2401, 2419], 'used': [901, 934, 2600, 3964, 4097], 'strategy': [904], 'lower': [906, 1079], 'plasma': [907, 943, 1080, 1294, 1691, 2111, 2454, 2910, 4258], 'levels.': [909], 'Blocking': [910], 'inhibiting': [914, 1346], 'main': [916], 'Niemann-Pick': [920], 'C1-like': [921], '1': [922, 3511, 3734], '(NPC1L1)': [923], 'increases': [924, 1328], 'LDL-receptor': [930], 'expression': [931, 4308], 'therapy': [937, 976], 'LDL-cholesterol': [944], '(LDL-C)': [945], 'levels': [946, 1082, 1257, 4228], 'improve': [948], '(9Cannon': [951], 'C.P.': [952, 2316, 3068], 'Blazing': [953], 'M.A.': [954], 'Giugliano': [955], 'R.P.': [956], 'McCagg': [957], 'White': [959], 'J.A.': [960, 3120], 'Theroux': [961], 'P.': [962, 1094, 2711], 'Darius': [963], 'H.': [964, 1234, 1670, 1716, 2099, 2272, 2360, 2433, 2479, 2889, 2935, 3114, 3540, 3805], 'Lewis': [965], 'B.S.': [966], 'Ophuis': [967], 'T.O.': [968], 'Jukema': [969], 'J.W.': [970], 'et': [971, 1567, 1730, 1758, 2232, 2286, 2493, 2812, 2949, 3687, 4142], 'al.Ezetimibe': [972], 'added': [973], 'statin': [975], 'after': [977, 3443, 3470], 'acute': [978], 'syndromes.N.': [980], 'Engl.': [981], 'Med': [983], '372:': [986], '2387-2397Crossref': [987], '(2778)': [990], 'Increasing': [993], 'achieved': [1002], 'targeting': [1004], 'BA': [1005, 1007, 1024, 1031, 1072, 1325, 1350, 1490, 2616, 3867, 4080], 'homeostasis.': [1006], 'sequestrants': [1008, 1073, 1104], 'bind': [1009], 'inside': [1011], 'lumen,': [1014], 'thereby': [1015, 1415], 'preventing': [1016], 'their': [1017, 1329], 'ultimately': [1019], 'resulting': [1020], 'compensatory': [1028], 'increase': [1029, 3128], 'synthesis': [1032, 1338, 1367, 3131, 4132], '(10Einarsson': [1035], 'Ericsson': [1037], 'Ewerth': [1039], 'Reihnér': [1041], 'E.': [1042, 1096], 'Rudling': [1043], 'M.': [1044, 1092, 1427, 1429, 1556, 1566, 1712, 1714, 1830, 2221, 2231, 2268, 2270, 2475, 2477, 2625, 2627, 2744, 2801, 2811, 2931, 2933, 3036, 3106, 3794, 3796], 'Stahlberg': [1045], 'D.': [1046, 1226, 3818], 'Angelin': [1047], 'B.': [1048], 'Bile': [1049, 3573], 'sequestrants:': [1051], 'mechanisms': [1052], 'action': [1054], 'metabolism.Eur.': [1060], 'Clin.': [1062], 'Pharmacol.': [1063, 1263], '1991;': [1064], 'S53-S58Crossref': [1066], '(0)': [1069], 'have': [1074, 2400], 'shown': [1076, 1148, 3340], 'effectively': [1078], 'LDL-C': [1081], 'animal': [1084, 1156, 2726], 'humans': [1090, 1522, 1576, 2241, 2821], '(11Mazidi': [1091], 'Rezaie': [1093], 'Karimi': [1095], 'Kengne': [1097], 'A.P.': [1098], 'effects': [1100, 2201], 'profile': [1107], 'blood': [1109, 1526, 4261], 'glucose': [1110], 'concentrations:': [1111], 'systematic': [1113], 'review': [1114], 'meta-analysis': [1116], 'controlled': [1119, 3990], 'trials.Int.': [1120], '227:': [1125], '850-857Abstract': [1126], '(43)': [1134], 'ASBT': [1137, 1318, 1347, 1381, 1478, 2690], 'works': [1139], 'several': [1155], '(12Lan': [1158], 'Haywood': [1160, 1422, 2620], 'Dawson': [1162, 2713], 'P.A.': [1163, 1377, 1421, 2619], 'Inhibition': [1164, 1194], 'basolateral': [1170], 'transport': [1173, 1199, 1570, 1618, 1960, 2235, 2815], 'reduces': [1174, 1254, 1297, 1319], 'apoE−/−': [1177, 1204], 'mice.Atherosclerosis.': [1178], '229:': [1180], '374-380Abstract': [1181], '(27)': [1189], '13Bhat': [1192], 'B.G.': [1193], 'reduced': [1201], 'SC-435.J.': [1207], 'Lipid': [1208, 3139], 'Res.': [1209, 3140], '2003;': [1210, 1302, 1454, 2652], '44:': [1211], '1614-1621Abstract': [1212], '(79)': [1220], '14Kitayama': [1223], 'Nakai': [1225], 'Kono': [1227], 'van': [1229, 1546, 1663, 1668, 1721, 1773, 1819, 1828, 1883, 2211, 2277, 2314, 2317, 2426, 2431, 2484, 2523, 2791, 2882, 2887, 2940, 2979, 3025, 3034, 3066, 3069, 3306, 3534, 3691, 4047, 4146], 'der': [1230, 1660, 1756, 1768, 1814, 1878, 2318, 2423, 2518, 2879, 2974, 3020, 3070], 'Hoop': [1231], 'A.G.': [1232], 'Kurata': [1233], 'Wit': [1236], 'E.C.': [1237], 'Cohen': [1238], 'L.H.': [1239], 'Inaba': [1240], 'Kohama': [1242], 'non-systemic': [1245], 'inhibitor': [1246, 1292, 3631], 'Na+-dependent': [1250], 'hamsters': [1259], 'monkeys.Eur.': [1261], '2006;': [1264], '539:': [1265], '89-98Crossref': [1266], '(37)': [1269], '15West': [1272], 'K.L.': [1273], 'Zern': [1274], 'T.L.': [1275], 'Butteiger': [1276], 'D.N.': [1277], 'Keller': [1278], 'B.T.': [1279], 'Fernandez': [1280], 'M.L.': [1281], 'SC-435,': [1282], 'an': [1283, 2185, 3407, 3502], 'sodium': [1286, 3736], 'co-dependent': [1287], '(ASBT)': [1291], 'lowers': [1293, 1481], 'guinea': [1300], 'pigs.Atherosclerosis.': [1301], '171:': [1303], '201-210Abstract': [1304], '(57)': [1312], 'BAs.': [1323], 'Like': [1324], 'sequestrants,': [1326], 'this': [1327, 3588], 'excretion,': [1331], 'compensated': [1334], 'cholesterol.': [1340], 'Interrupting': [1341], 'decreases': [1348], 'pool': [1351, 2617, 4134], '(i.e.,': [1352], 'total': [1354, 1793, 1903, 2543, 2999, 3209, 3850, 4018, 4205, 4222, 4245], 'amount': [1355, 3851], 'present': [1358, 1517], 'circulation)': [1362], 'because': [1363], 'induction': [1365], 'cannot': [1368], 'completely': [1369], 'compensate': [1370], 'loss': [1375, 1647, 2060, 2117, 2866], '(16Dawson': [1376], 'Roles': [1378], 'OSTα-OSTβ': [1383], 'regulating': [1385], 'signaling.Dig.': [1388], 'Dis.': [1389], '35:': [1391], '261-266Crossref': [1392], '(24)': [1395], 'availability': [1403], 'lumen': [1409], 'solubilization': [1412], '(17Dawson': [1420, 2618], 'Craddock': [1424, 2622], 'A.L.': [1425, 2623], 'Wilson': [1426, 2624], 'Tietjen': [1428, 2626], 'Kluckman': [1430, 2628], 'Maeda': [1432, 2630], 'Parks': [1434, 2632], 'J.S.': [1435, 2633], 'Targeted': [1436, 2634], 'deletion': [1437, 2635], 'eliminates': [1444, 2642], 'cycling': [1446, 2644], 'mice.J.': [1451, 2649, 3138], 'Biol.': [1452, 1693, 2456, 2650, 2912, 3327, 3712, 4068, 4167], 'Chem.': [1453, 1694, 2457, 2651, 2913], '278:': [1455, 2653], '33920-33927Abstract': [1456, 2654], '(260)': [1464, 2662], 'contrast': [1469], 'ezetimibe,': [1471, 2184, 2594], 'directly': [1473, 1762], 'inhibits': [1474, 2596], 'absorption,': [1477], 'indirectly': [1480, 1927], 'through': [1485, 2611], 'reduction': [1487, 2032, 2089, 2613], 'pool.': [1491], 'A': [1492, 1635, 2854, 4014, 4201], 'nonbiliary': [1494], 'pathway': [1495], 'contributes': [1497, 1790, 1900, 2540, 2996], 'recently': [1505], 'identified.': [1507], 'pathway,': [1509], 'known': [1510], 'transintestinal': [1512, 1534, 1736, 1838, 2292, 2499, 2955, 3044], '(TICE),': [1515], '(18Vrins': [1523], 'C.L.J.': [1524, 1667, 1772, 1818, 1882, 2322, 2430, 2522, 2886, 2978, 3024, 3074], 'From': [1525], 'gut:': [1528], 'direct': [1529, 1837, 3043], 'secretion': [1530, 1789, 1866, 1899, 2071, 2539, 2995], 'efflux.World': [1536], 'Gastroenterol.': [1538], '16:': [1540], '5953-5957PubMed': [1541], '19Jakulj': [1544], 'L.': [1545, 2210, 2311, 2790, 3063, 3112], 'Dijk': [1547, 1664, 1722, 2212, 2278, 2427, 2485, 2792, 2883, 2941, 3307, 3692, 3809, 4048, 4147], 'T.H.': [1548, 1665, 1723, 2213, 2279, 2428, 2486, 2793, 2884, 2942, 3308, 3693, 3810, 4049, 4148], 'Freark': [1549, 2214, 2794, 3107], 'Boer': [1551, 1559, 1709, 1953, 2216, 2224, 2265, 2472, 2796, 2804, 2928, 3109, 3800], 'Kootte': [1553, 2218, 2798], 'R.S.': [1554, 2219, 2799], 'Schonewille': [1555, 1711, 2220, 2267, 2474, 2800, 2930], 'Paalvast': [1557, 2222, 2802], 'Bloks': [1561, 1717, 2226, 2273, 2480, 2806, 2936, 3115], 'V.W.': [1562, 1718, 2227, 2274, 2481, 2807, 2937, 3116], 'Boverhof': [1563, 1726, 2048, 2228, 2282, 2489, 2808, 2945, 3806], 'Nieuwdorp': [1565, 2230, 2810], 'al.Transintestinal': [1568, 2233, 2813], 'active': [1572, 2237, 2817], 'controls': [1578, 1735, 2036, 2243, 2291, 2498, 2823, 2954], 'ezetimibe-induced': [1579, 2244, 2824], 'excretion.Cell': [1583, 2248, 2828], 'Metab': [1584, 1971, 2249, 2829], '2016;': [1586, 2251, 2379, 2831, 3141, 3328, 3713, 4069, 4168], '24:': [1587, 2252, 2832, 3568], '783-794Abstract': [1588, 2253, 2833], '(98)': [1596, 1751, 2261, 2307, 2514, 2841, 2970], 'molecular': [1600], 'fully': [1607], 'elucidated.': [1608], 'However,': [1609], 'least': [1613], 'partly': [1614], 'dependent': [1615], 'ABCG': [1620], 'members': [1621], '5': [1622, 3578, 3590], '8': [1624], '(20Brufau': [1625], 'G.': [1626, 2845, 3124, 3543], 'Kuipers': [1627, 1679, 1782, 1831, 1892, 1955, 2054, 2108, 2442, 2532, 2846, 2898, 2988, 3037, 3819], 'Lin': [1629, 2848], 'Trautwein': [1631, 2850], 'E.A.': [1632, 2851], 'Groen': [1633, 1677, 1784, 1833, 1894, 1957, 1990, 2052, 2106, 2329, 2440, 2534, 2852, 2896, 2990, 3039, 3081, 3125, 3311, 3696, 3823, 4052, 4151], 'A.K.': [1634, 1678, 1785, 1834, 1895, 1958, 1991, 2053, 2107, 2330, 2441, 2535, 2853, 2897, 2991, 3040, 3082, 3126, 3312, 3697, 3824, 4053, 4152], 'reappraisal': [1636, 2855], 'plant': [1642, 2861], 'promote': [1644, 2863], 'mice.PLoS': [1649, 2868], 'One.': [1650, 2378, 2869], '6:': [1652, 2871, 3329, 3714, 4070, 4169], 'e21576Crossref': [1653, 2872], '(65)': [1656, 2875], '21van': [1659, 2878], 'Veen': [1661, 2319, 2424, 2880, 3071], 'J.N.': [1662, 2320, 2425, 2881, 3072], 'Vrins': [1666, 1771, 1817, 1881, 2321, 2429, 2521, 2885, 2977, 3023, 3073], 'Meer': [1669, 2432, 2888], 'Havinga': [1671, 2046, 2096, 2434, 2890, 3544, 3802], 'Bijsterveld': [1673, 2436, 2892], 'Tietge': [1675, 2438, 2894, 3121], 'U.J.F.': [1676, 2439, 2895, 3122], 'Activation': [1681, 2444, 2900], 'stimulates': [1687, 2332, 2450, 2906, 3084], 'trans-intestinal': [1688, 2451, 2907], 'cholesterol.J.': [1692, 2455, 2911], '2009;': [1695, 2458, 2914], '284:': [1696, 2459, 2915], '19211-19219Abstract': [1697, 2460, 2916], '(170)': [1705, 2468, 2924], '22de': [1708, 2264, 2471, 2927], 'J.F.': [1710, 1954, 2266, 2473, 2929], 'Boesjes': [1713, 2269, 2476, 2932, 3795], 'Wolters': [1715, 1728, 2098, 2271, 2284, 2478, 2491, 2934, 2947, 3113, 3117, 3539, 3804], 'Bos': [1719, 2275, 2482, 2938, 3797], 'Jurdzinski': [1724, 2280, 2487, 2943], 'J.C.': [1729, 2285, 2492, 2948, 3118], 'al.Intestinal': [1731, 2287, 2494, 2950], 'mice.Gastroenterology.': [1740, 1799, 1909, 2073, 2124, 2296, 2503, 2549, 2959, 3005], '152:': [1742, 2298, 2505, 2961], '1126-1138.e6Abstract': [1743, 2299, 2506, 2962], 'Originally,': [1754], 'Van': [1755, 3808], 'Velde': [1757, 1769, 1815, 1879, 2519, 2975, 3021], 'al.': [1759, 3688, 4143], 'quantified': [1760], 'perfusion': [1765], 'studies': [1766, 2029, 2144, 2775], '(23van': [1767, 1877], 'A.E.': [1770, 1816, 1880, 2520, 2976, 3022], 'den': [1774, 1820, 1884, 2524, 2980, 3026], 'Oever': [1775, 1821, 1885, 2525, 2981, 3027], 'Kunne': [1777, 1887, 2323, 2527, 2983, 3075], 'C.': [1778, 1888, 2324, 2528, 2984, 3076, 3790], 'Oude': [1779, 1825, 1889, 2529, 2985, 3031], 'Elferink': [1780, 1826, 1890, 2104, 2530, 2986, 3032], 'R.P.J.': [1781, 1827, 1891, 2531, 2987, 3033], 'Direct': [1786, 1896, 2536, 2992], 'significantly': [1791, 1901, 2541, 2997], '2007;': [1800, 1910, 2550, 3006], '133:': [1801, 1911, 2551, 3007], '967-975Abstract': [1802, 1912, 2552, 3008], '(159)': [1810, 1920, 2560, 3016], '24van': [1813, 3019], 'Seemann': [1823, 3029], 'I.': [1824, 2356, 3030], 'Eck': [1829, 3035], 'Regulation': [1835, 3041], 'mice.Am.': [1842, 3048], 'Physiol.': [1844, 3050, 4025, 4212], 'Liver': [1845, 3051, 4183, 4221], 'Physiol': [1846, 3052], '2008;': [1848, 3054], '295:': [1849, 3055], 'G203-G208Crossref': [1850, 3056], '(92)': [1853, 3059], 'estimated': [1859], 'impaired': [1863, 1942, 2010, 2583], 'biliary': [1864, 1934, 1943, 2011, 2069, 2194, 3866], 'such': [1867, 2014], 'Abcg8': [1870], 'multidrug-resistant': [1872, 2017], 'protein': [1873, 2018], '2': [1874, 2019, 2122, 3726, 3748], 'knockout': [1875, 2020], 'mouse': [1876], 'study': [1924], 'others': [1926], 'calculated': [1928, 2140, 2203, 3857, 4119, 4137], 'subtracting': [1931], 'dietary': [1932, 1937, 2196, 4083], '(or': [1935], 'case': [1940], 'secretion)': [1944], 'input': [1945, 2197], 'NS': [1948, 2165, 2191, 4078, 4122], 'output': [1949, 4123], '[reviewed': [1950], '(25de': [1952], 'revisited:': [1961], 'turbo': [1964], 'drive': [1967], 'excretion.Trends': [1969], 'Endocrinol.': [1970], '2018;': [1973, 1999], '29:': [1974, 2000], '123-133Abstract': [1975], '(33)': [1983], '26Reeskamp': [1986], 'L.F.': [1987], 'Meessen': [1988], 'E.C.E.': [1989], 'humans.Curr.': [1996], 'Opin.': [1997], 'Lipidol.': [1998], '10-17Crossref': [2001], '(28)': [2004], 'Scholar)].': [2006], 'secretion,': [2013], 'mouse,': [2021], 'still': [2026], 'high,': [2027], 'showing': [2030], 'no': [2031], 'compared': [2033], 'WT': [2035, 2701], '(∼50%': [2037], 'genotypes)': [2041], '(27Kruit': [2042], 'J.K.': [2043], 'Plösch': [2044], 'Groot': [2050], 'P.H.E.': [2051], 'Increased': [2056], 'upon': [2061], 'activation': [2065, 2208, 2399], '2005;': [2074], '128:': [2075], '147-156Abstract': [2076], '(132)': [2084], 'Scholar)': [2086], '70%': [2091], '40%': [2093], '(28Voshol': [2094], 'P.J.': [2095], 'Ottenhoff': [2100], 'Princen': [2102, 3548], 'H.M.G.': [2103], 'R.P.J.O': [2105], 'Reduced': [2110], 'multidrug': [2119], 'resistance': [2120], 'gene': [2121, 3654], 'P-glycoprotein-deficient': [2123], '1998;': [2125, 2766], '114:': [2126], '1024-1034Abstract': [2127], 'yields': [2145], 'minimum': [2147], 'estimation,': [2148], 'it': [2150], 'unclear': [2152], 'what': [2154], 'degree': [2155], 'transintestinally': [2159], 'excreted': [2160, 2576], 'contributed': [2162], 'excretion.': [2166], 'notion': [2168], 'occurs': [2174], 'could': [2175], 'hypothesized': [2177], 'experiments': [2182, 3242, 3261], 'NPC1L1': [2186], 'inhibitor,': [2187], 'potentiated': [2199], '(19Jakulj': [2209, 2789], '29Jakulj': [2310, 3062], 'Vissers': [2312, 3064], 'M.N.': [2313, 3065], 'Roomen': [2315, 3067], 'Stellaard': [2325, 3077], 'Kastelein': [2327, 3079], 'J.J.P.': [2328, 3080], 'Ezetimibe': [2331, 2367, 3083], 'faecal': [2333, 3085], 'depending': [2337, 3089], 'abcg8': [2339, 3091], 'function': [2340, 3092], 'mice.FEBS': [2342, 3094], 'Lett': [2343, 3095], '584:': [2346, 3098], '3625-3628Crossref': [2347, 3099], '(35)': [2350, 3102], '30Nakano': [2353], 'Inoue': [2355], 'Takenaka': [2357], 'Ono': [2359], 'Katayama': [2361], 'Awata': [2363], 'Murakoshi': [2365], 'promotes': [2368], 'brush': [2369], 'border': [2370], 'membrane-to-lumen': [2371], 'efflux': [2373], 'small': [2376, 3621], 'intestine.PLoS': [2377], '11:': [2380], 'e0152207Crossref': [2381], '(30)': [2384], 'While': [2387, 2728], 'various': [2388], 'including': [2390], 'high-fat': [2391], 'feeding,': [2393], 'LXR': [2394], 'activation,': [2395], '(intestinal)': [2397], 'implied': [2402], 'affect': [2404, 3561], 'TICE,': [2405], 'possible': [2407], 'role': [2408], 'originating': [2414], 'addressed': [2420], 'rigorously': [2421], '(21van': [2422], '23van': [2517, 2973], 'current': [2565], 'study,': [2566], 'investigated': [2568], 'intestinally': [2575], 'using': [2579, 2593, 3294, 4232, 4253, 4275, 4297], '(re)absorption.': [2585], 'First,': [2586], 'NPC1L1.': [2597], 'Second,': [2598], 'Asbt−/−': [2601, 2698], 'display': [2604], 'partial': [2606], 'impairment': [2607], 'quantitated': [2669], 'fluxes': [2671, 2779, 3285, 3319, 3704, 4060, 4159], 'measured': [2673, 3287, 3783, 4105], 'Finally,': [2677], 'body.': [2697], 'littermates': [2702], 'C57BL/6': [2705, 2787], 'background': [2706, 2788], 'originally': [2708], 'generated': [2709], '(Emory': [2714], 'University,': [2715], 'Atlanta,': [2716], 'GA)': [2717], 'bred': [2719], 'University': [2722, 3237, 3247, 3257], 'Medical': [2723, 3238], 'Center': [2724, 3239], 'Groningen': [2725, 3249], 'facility.': [2727], 'there': [2729], 'established': [2731], 'differences': [2732, 2750], 'metabolism': [2735, 2756, 3554], 'male': [2737, 2783, 3167], 'female': [2739], '(31Turley': [2741], 'S.D.': [2742], 'Schwarz': [2743], 'Spady': [2745], 'D.K.': [2746], 'Dietschy': [2747], 'J.M.': [2748, 3536], 'Gender-related': [2749], 'outbred': [2758], 'CD-1': [2759], 'fed': [2761], 'high-cholesterol': [2764], 'diets.Hepatology.': [2765], '28:': [2767], '1088-1094Crossref': [2768], '(83)': [2771], 'performed': [2781, 3263, 4311], '20Brufau': [2844], '32Schonewille': [3105], 'Mele': [3111], 'Kuivenhoven': [3119], 'Brufau': [3123], 'Statins': [3127], 'stimulate': [3133], 'elimination': [3136], '57:': [3142], '1455-1464Abstract': [3143], 'able': [3156], 'best': [3158], 'relate': [3159], 'our': [3160], 'previously': [3163, 3302, 3530, 3787], 'published': [3164], 'studies,': [3165], '(aged': [3169], '10–18': [3170], 'weeks)': [3171], 'used.': [3173], 'Mice': [3174, 3276], 'conventionally': [3176], 'housed': [3177], 'individual': [3179, 3863, 4263], 'cages': [3180], 'temperature-': [3183], 'light-controlled': [3185], 'facility': [3186], '12-h': [3189], 'light-dark': [3190], 'cycle.': [3191], 'had': [3194], 'ad': [3195], 'libitum': [3196], 'access': [3197], 'water': [3199, 3454], 'maintenance': [3201], 'laboratory': [3202, 3272], 'chow': [3203], '(macronutrient': [3204], 'ratio': [3205], 'percentage': [3207], 'calories;': [3210], 'fat:': [3211], '7.5%,': [3212], 'proteins:': [3213], '17.5%,': [3214], 'carbohydrates:': [3216], '75%)': [3217], 'containing': [3218, 3455, 3628], '0.008%': [3219], '(RM1': [3221], 'FG;': [3222], 'Special': [3223], 'Diet': [3224], 'Services,': [3225], 'Witham,': [3226], 'UK)': [3227], 'without': [3230], '(0.005%;': [3232], '50': [3233, 3677], 'mg/kg': [3234], 'chow)': [3235], '(Ezetrol;': [3236], 'Groningen).': [3240], 'Animal': [3241, 3253], 'approved': [3244], 'Ethics': [3250], 'Committee': [3251], 'Experiments': [3254], 'Groningen.': [3259], 'All': [3260, 3656], 'accordance': [3265], 'relevant': [3267], 'guidelines': [3268], 'regulations': [3270], '(including': [3271], 'biosafety': [3274], 'regulations).': [3275], 'received': [3277, 3453], 'ezetimibe-enriched': [3279], '3': [3282, 3920], 'weeks.': [3283], 'last': [3290, 4109], '10': [3291, 3491, 3941], 'days': [3292, 3345], 'dual': [3296], 'stable': [3297], 'isotope': [3298], 'tracer': [3299], 'method': [3300, 4016, 4203], 'described': [3303, 3531, 3684, 3788, 4139], '(33Ronda': [3304, 3689, 4045, 4144], 'O.A.H.O': [3305, 3690, 4046, 4145], 'Verkade': [3309, 3694, 3821, 4050, 4149], 'H.J.': [3310, 3695, 3822, 4051, 4150], 'Measurement': [3313, 3698, 4054, 4153], 'peripheral': [3317, 3702, 4058, 4157], 'dual-tracer': [3322, 3707, 4063, 4162], 'method.Curr.': [3324, 3709, 4065, 4164], 'Protoc.': [3325, 3710, 4066, 4165], 'Mouse': [3326, 3711, 4067, 4166], '408-434Crossref': [3330, 3715, 4071, 4170], '(7)': [3333, 3718, 4074, 4173], 'experimental': [3337, 4269], 'setup': [3338], 'Fig.': [3342], '1.': [3343], 'Three': [3344], 'prior': [3346], 'start': [3349], 'experiment,': [3352], 'bloodspots': [3353, 3461], '24': [3355, 4110], 'h': [3356, 3442, 3449, 3469, 3727, 4111], 'collected': [3359, 3429, 3463, 3484, 3574, 3594], 'baseline': [3361], 'measurements,': [3362, 3868, 4260], 'food': [3364, 3477], 'intake': [3365, 3478, 4085, 4127], 'weight': [3368, 3475], 'measured.': [3370], 'day': [3372, 3487, 3490, 3495], '0,': [3373], 'anesthetized': [3377, 3500], 'isoflurane': [3379], 'given': [3381], 'retro-orbital': [3383], 'injection': [3384, 3504, 3955], '0.3': [3386], 'mg': [3387, 3412, 3678], 'D5-cholesterol': [3388], '(Medical': [3389], 'Isotopes': [3390], 'Inc.,': [3391, 3417], 'Pelham,': [3392], 'NH)': [3393], 'dissolved': [3394, 3420], '150': [3396], 'μl': [3397, 3423, 4002], 'Intralipid': [3398], '20%': [3399], '(Fresenius': [3400], 'Kabi,': [3401], 'Den': [3402], 'Bosch,': [3403], 'Netherlands)': [3405], 'oral': [3408], 'gavage': [3409], '0.6': [3411], 'D7-cholesterol': [3413], '(Cambridge': [3414], 'Isotope': [3415], 'Laboratories,': [3416], 'Andover,': [3418], 'MA)': [3419], '200': [3422, 3907], 'medium-chain': [3424], 'triglyceride': [3425, 4227, 4291], 'oil.': [3426], 'Bloodspots': [3427], '3,': [3431], '6,': [3432], '12,': [3433], '24,': [3434, 3464], '48,': [3435, 3466], '72,': [3436], '96,': [3437], '120,': [3438], '144,': [3439], '168': [3441, 3448], 'labeled': [3444], 'administration.': [3446], 'At': [3447], '(day': [3450, 4112], '8),': [3451], '2%': [3456], '1-13Cacetate': [3457], 'until': [3458], 'termination,': [3459], '32,': [3465], '72': [3468], 'starting': [3471], '1-13Cacetate.': [3473], 'Body': [3474], 'determined,': [3480], 'daily': [3485], '0': [3488], '(Fig.': [3492], '1).': [3493], '10,': [3496], 'intraperitoneal': [3503], 'mixture': [3507, 3732], 'Hypnorm': [3509], '(fentanyl/fluanisone;': [3510], 'ml/kg)': [3512], 'diazepam': [3514], '(10': [3515, 3953], 'mg/kg).': [3516], 'cannulated': [3520], 'early': [3521], 'light': [3524], 'phase': [3525], '(at': [3526], '9:00': [3527], 'AM)': [3528], '(34Kuipers': [3532], 'Ree': [3535], 'Hofker': [3537], 'M.H.': [3538], "In't": [3541], 'Veld': [3542], 'Vonk': [3546], 'R.J.': [3547], 'Havekes': [3550], 'L.M.': [3551], 'Altered': [3552], 'apolipoprotein': [3556], 'E-deficient': [3557], 'does': [3559], 'across': [3564], 'liver.Hepatology.': [3566], '1996;': [3567], '241-247Crossref': [3569], 'first': [3577, 3589], 'min': [3579, 3597, 3921], 'discarded': [3581], 'avoid': [3583], 'collecting': [3584], 'concentrated': [3585], 'bile.': [3586], 'After': [3587, 3943], 'min,': [3591], '20': [3596], 'preweighed': [3599], 'tubes,': [3600], 'placed': [3604], 'humidified': [3607], 'incubator': [3608], '(37°C)': [3609], 'maintain': [3611], 'temperature.': [3613], 'Blood': [3614], 'obtained': [3616], 'cardiac': [3618], 'puncture.': [3619], 'intestines': [3622], 'flushed': [3624], 'ice-cold': [3626], 'PBS': [3627, 4191], 'protease': [3630], '(cOmplete;': [3632], 'Roche': [3633, 4241, 4305], 'Diagnostics,': [3634], 'Mannheim,': [3635], 'Germany)': [3636], 'cut': [3638], 'three': [3640], 'segments': [3641, 3658], 'equal': [3643], 'length;': [3644], 'middle': [3646], 'piece': [3647], 'segment': [3650], 'excised': [3652], 'analysis.': [3655], 'immediately': [3660], 'snap-frozen': [3661], 'liquid': [3663, 4181], 'nitrogen.': [3664, 4182], '(cholesterol': [3666], 'bacterial': [3669], 'samples)': [3673], 'extracted': [3675, 3744, 3761, 3999, 4186], 'air-dried,': [3679], 'ground': [3680, 4179], 'samples': [3682, 3870, 3903, 3946], 'Ronda': [3686, 4141], 'Briefly,': [3721], 'heated': [3724], '80°C': [3729], 'M': [3735], 'hydroxide': [3737], 'methanol': [3739, 3910], '(1:3).': [3740], 'then': [3743, 4037, 4230], 'times': [3746], 'ml': [3749], 'petroleum': [3750], 'ether': [3751], 'derivatized': [3753, 3774, 4038], 'N,O-bis(trimethylsilyl)trifluoroacetamide': [3755], '(BSTFA)-pyridine-trimethylchlorosilane': [3756], '(TMCS)': [3757], '(5:5:0.1).': [3758, 3777], 'Sep-Pak': [3765], 'C-18': [3766], 'columns,': [3767], 'methylated': [3768], 'methanol-acetyl': [3770], 'chloride': [3771], '(20:1),': [3772], 'BSTFA-pyridine-TMCS': [3776, 4040], 'GC': [3785, 4043], '(35Out': [3789], 'Patankar': [3791], 'J.V.': [3792], 'Doktorova': [3793], 'De': [3799], 'Smoczek': [3811], 'Bleich': [3813], 'Sachdev': [3815], 'V.': [3816], 'Kratky': [3817], 'Gut': [3825], 'microbiota': [3826], 'Asbt-dependent': [3828], 'Gata4.J.': [3834], 'Hepatol.': [3835], '63:': [3837], '697-704Abstract': [3838], '(78)': [3846], 'sum': [3860], 'species.': [3864], 'For': [3865, 3957, 4257], 'diluted': [3872], '1,000-fold': [3873], 'Milli-Q': [3875], 'water.': [3876], 'Samples': [3877], 'centrifuged': [3879, 3918, 3936], '15,800': [3881], 'g,': [3882], 'supernatant': [3885, 3926], 'poured': [3887], 'clean': [3890], 'glass': [3891], 'tube.': [3892], 'fluid': [3894], 'evaporated': [3896], 'nitrogen': [3898], '40°C.': [3900], 'Before': [3901], 'measuring,': [3902], 'reconstituted': [3905], 'µl': [3908, 3954], 'water,': [3912], 'vortexed': [3913], '60': [3915], 's,': [3916], '1,800': [3923], 'g.': [3924], 'transferred': [3928, 3948], '0.2': [3931], 'µm': [3932], 'spin': [3933], 'filter': [3934], '2,000': [3938], 'g': [3939], 'min.': [3942], 'filtering,': [3944], 'vials': [3950], 'analyzed': [3952], 'volume).': [3956], 'quantitative': [3959], 'determination': [3960], 'BAs,': [3962], 'Nexera': [3966], 'X2': [3967], 'ultra-high-performance': [3968], 'LC': [3969, 4277], 'system': [3970, 3988], '(Shimadzu,': [3971], 'Kyoto,': [3972], 'Japan)': [3973], 'coupled': [3974], 'QTRAP': [3977], '4500': [3978], 'MD': [3979, 3993], 'triple-quadrupole': [3980], 'mass': [3981], 'spectrometer': [3982], '(SCIEX,': [3983], 'Framingham,': [3984], 'MA).': [3985], 'LC/MS/MS': [3987], 'Analyst': [3992], '1.6.2': [3994], 'software.': [3995], 'Biliary': [3996, 4034], '15': [4001], 'according': [4005, 4192], 'Bligh': [4007, 4194], 'Dyer': [4009, 4012, 4196, 4199], '(36Bligh': [4010, 4197], 'E.G.': [4011, 4198], 'W.J.': [4013, 4200], 'rapid': [4015, 4202], 'extraction': [4020, 4207], 'purification.Can.': [4022, 4209], 'Biochem.': [4024, 4211], '1959;': [4026, 4213], '37:': [4027, 4214], '911-917Crossref': [4028, 4215], '(42694)': [4031, 4218], '(5:5:0.1)': [4041], 'measurement': [4044], 'Fecal': [4077], 'among': [4088], 'all': [4089], 'days.': [4090], 'Data': [4091], 'displayed': [4092], 'figures': [4095], 'calculate': [4099], 'represent': [4104], 'values': [4106], '10).': [4113], 'Net': [4114], 'nonhepatobiliary': [4115], '[fecal': [4121], '−': [4124], '(dietary': [4125], '+': [4128], 'hepatobiliary': [4129], 'secretion)].': [4130], 'size': [4135], 'Livers': [4176], 'mechanically': [4178], 'homogenates': [4189], 'free': [4224, 4248], 'determined': [4231, 4251, 4296], 'commercially': [4233, 4298], 'available': [4234, 4299], 'reagents': [4235, 4300], '(DiaSys': [4236, 4301], 'Diagnostic': [4237, 4302], 'Systems,': [4238], 'Holzheim,': [4239], 'Germany;': [4240], 'Diagnostics).': [4242, 4306], 'Plasma': [4243, 4271], 'triglycerides,': [4244], 'spectrophotometrically': [4252], 'same': [4255], 'kits.': [4256], 'lipoprotein': [4259], 'pooled': [4266], 'group.': [4270], 'lipoproteins': [4272], 'fractionated': [4274], 'fast-protein': [4276], 'Superose': [4280], '6': [4281], '10/300': [4282], 'GL': [4283], 'column': [4284], '(GE': [4285], 'Healthcare,': [4286], 'Uppsala,': [4287], 'Sweden).': [4288], 'concentrations': [4292], 'fractions': [4294], 'Systems': [4303], 'Gene': [4307], 'analysis': [4309], 'duodenum.': [4316], 'Total': [4317], 'RNA': [4318], 'isolated': [4320], 'TRI': [4322], 'R': [4323]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2964010750', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 8}], 'updated_date': '2024-12-24T02:59:51.447251', 'created_date': '2019-07-30'}