Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2961632360', 'doi': 'https://doi.org/10.1172/jci.insight.129397', 'title': 'SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1', 'display_name': 'SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1', 'publication_year': 2019, 'publication_date': '2019-08-08', 'ids': {'openalex': 'https://openalex.org/W2961632360', 'doi': 'https://doi.org/10.1172/jci.insight.129397', 'mag': '2961632360', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31310592', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6693888'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci.insight.129397', 'pdf_url': 'http://insight.jci.org/articles/view/129397/files/pdf', 'source': {'id': 'https://openalex.org/S2764964142', 'display_name': 'JCI Insight', 'issn_l': '2379-3708', 'issn': ['2379-3708'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://insight.jci.org/articles/view/129397/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068875042', 'display_name': 'Clair Crewe', 'orcid': 'https://orcid.org/0000-0002-3117-5327'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Clair Crewe', 'raw_affiliation_strings': ['Touchstone Diabetes Center,'], 'affiliations': [{'raw_affiliation_string': 'Touchstone Diabetes Center,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000296373', 'display_name': 'Yi Zhu', 'orcid': 'https://orcid.org/0000-0003-1650-1363'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yi Zhu', 'raw_affiliation_strings': ['Touchstone Diabetes Center,'], 'affiliations': [{'raw_affiliation_string': 'Touchstone Diabetes Center,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048827629', 'display_name': 'Vivian A. Paschoal', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Vivian A. Paschoal', 'raw_affiliation_strings': ['Touchstone Diabetes Center,'], 'affiliations': [{'raw_affiliation_string': 'Touchstone Diabetes Center,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005041059', 'display_name': 'Nolwenn Joffin', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Nolwenn Joffin', 'raw_affiliation_strings': ['Touchstone Diabetes Center,'], 'affiliations': [{'raw_affiliation_string': 'Touchstone Diabetes Center,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017395128', 'display_name': 'Alexandra L. Ghaben', 'orcid': 'https://orcid.org/0000-0001-7377-7820'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Alexandra L. Ghaben', 'raw_affiliation_strings': ['Touchstone Diabetes Center,'], 'affiliations': [{'raw_affiliation_string': 'Touchstone Diabetes Center,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041624980', 'display_name': 'Ruth Gordillo', 'orcid': 'https://orcid.org/0000-0001-6533-2493'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ruth Gordillo', 'raw_affiliation_strings': ['Touchstone Diabetes Center,'], 'affiliations': [{'raw_affiliation_string': 'Touchstone Diabetes Center,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040201199', 'display_name': 'Da Young Oh', 'orcid': 'https://orcid.org/0000-0003-0687-6479'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Da Young Oh', 'raw_affiliation_strings': ['Touchstone Diabetes Center,'], 'affiliations': [{'raw_affiliation_string': 'Touchstone Diabetes Center,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049226143', 'display_name': 'Guosheng Liang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091339', 'display_name': 'Laboratory of Molecular Genetics', 'ror': 'https://ror.org/00fwhek95', 'country_code': 'PL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210091339']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Guosheng Liang', 'raw_affiliation_strings': ['Department of Molecular Genetics, and'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, and', 'institution_ids': ['https://openalex.org/I4210091339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026744789', 'display_name': 'Jay D. Horton', 'orcid': 'https://orcid.org/0000-0002-7778-1074'}, 'institutions': [{'id': 'https://openalex.org/I4210091339', 'display_name': 'Laboratory of Molecular Genetics', 'ror': 'https://ror.org/00fwhek95', 'country_code': 'PL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210091339']}, {'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}, {'id': 'https://openalex.org/I4210145641', 'display_name': 'HumanN (United States)', 'ror': 'https://ror.org/04wkssk54', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210145641']}], 'countries': ['PL', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jay D. Horton', 'raw_affiliation_strings': ['Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas, USA.', 'Department of Molecular Genetics, and'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, and', 'institution_ids': ['https://openalex.org/I4210091339']}, {'raw_affiliation_string': 'Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas, USA.', 'institution_ids': ['https://openalex.org/I867280407', 'https://openalex.org/I4210145641']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077747436', 'display_name': 'Philipp E. Scherer', 'orcid': 'https://orcid.org/0000-0003-0680-3392'}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Philipp E. Scherer', 'raw_affiliation_strings': ['Touchstone Diabetes Center,'], 'affiliations': [{'raw_affiliation_string': 'Touchstone Diabetes Center,', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5077747436'], 'corresponding_institution_ids': [], 'apc_list': {'value': 4100, 'currency': 'USD', 'value_usd': 4100, 'provenance': 'doaj'}, 'apc_paid': {'value': 4100, 'currency': 'USD', 'value_usd': 4100, 'provenance': 'doaj'}, 'fwci': 6.777, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 42, 'citation_normalized_percentile': {'value': 0.891723, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '4', 'issue': '15', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11618', 'display_name': 'Cholesterol Metabolism and Atherosclerosis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11618', 'display_name': 'Cholesterol Metabolism and Atherosclerosis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11844', 'display_name': 'Lipid Metabolism and Storage in Organisms', 'score': 0.9893, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11072', 'display_name': 'Peroxisome Proliferator-Activated Receptors', 'score': 0.9818, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lipogenesis', 'display_name': 'Lipogenesis', 'score': 0.9126092}, {'id': 'https://openalex.org/keywords/carbohydrate-responsive-element-binding-protein', 'display_name': 'Carbohydrate-responsive element-binding protein', 'score': 0.8055439}, {'id': 'https://openalex.org/keywords/transcriptional-regulation', 'display_name': 'Transcriptional Regulation', 'score': 0.540901}, {'id': 'https://openalex.org/keywords/lipid', 'display_name': 'lipid', 'score': 0.523551}, {'id': 'https://openalex.org/keywords/lipid-droplets', 'display_name': 'Lipid Droplets', 'score': 0.509957}], 'concepts': [{'id': 'https://openalex.org/C141359234', 'wikidata': 'https://www.wikidata.org/wiki/Q2734301', 'display_name': 'Lipogenesis', 'level': 3, 'score': 0.9126092}, {'id': 'https://openalex.org/C85051948', 'wikidata': 'https://www.wikidata.org/wiki/Q416064', 'display_name': 'Sterol regulatory element-binding protein', 'level': 4, 'score': 0.8865223}, {'id': 'https://openalex.org/C2853687', 'wikidata': 'https://www.wikidata.org/wiki/Q18039976', 'display_name': 'Carbohydrate-responsive element-binding protein', 'level': 4, 'score': 0.8055439}, {'id': 'https://openalex.org/C98490376', 'wikidata': 'https://www.wikidata.org/wiki/Q14876060', 'display_name': 'mTORC1', 'level': 4, 'score': 0.6601311}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.6193744}, {'id': 'https://openalex.org/C2776175234', 'wikidata': 'https://www.wikidata.org/wiki/Q357519', 'display_name': 'Adipocyte', 'level': 3, 'score': 0.60331184}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.54740715}, {'id': 'https://openalex.org/C6929976', 'wikidata': 'https://www.wikidata.org/wiki/Q3771881', 'display_name': 'Regulator', 'level': 3, 'score': 0.5147031}, {'id': 'https://openalex.org/C171089720', 'wikidata': 'https://www.wikidata.org/wiki/Q193583', 'display_name': 'Adipose tissue', 'level': 2, 'score': 0.42500407}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4044507}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38573796}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.37905735}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37326723}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.27294865}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2538574}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.16409689}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.1482937}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.07030833}], 'mesh': [{'descriptor_ui': 'D017667', 'descriptor_name': 'Adipocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000273', 'descriptor_name': 'Adipose Tissue', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050155', 'descriptor_name': 'Lipogenesis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000076222', 'descriptor_name': 'Mechanistic Target of Rapamycin Complex 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051779', 'descriptor_name': 'Sterol Regulatory Element Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017667', 'descriptor_name': 'Adipocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000273', 'descriptor_name': 'Adipose Tissue', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000273', 'descriptor_name': 'Adipose Tissue', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050155', 'descriptor_name': 'Lipogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000076222', 'descriptor_name': 'Mechanistic Target of Rapamycin Complex 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051779', 'descriptor_name': 'Sterol Regulatory Element Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059467', 'descriptor_name': 'Transcriptome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci.insight.129397', 'pdf_url': 'http://insight.jci.org/articles/view/129397/files/pdf', 'source': {'id': 'https://openalex.org/S2764964142', 'display_name': 'JCI Insight', 'issn_l': '2379-3708', 'issn': ['2379-3708'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6693888', 'pdf_url': 'https://europepmc.org/articles/pmc6693888?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693888', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31310592', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci.insight.129397', 'pdf_url': 'http://insight.jci.org/articles/view/129397/files/pdf', 'source': {'id': 'https://openalex.org/S2764964142', 'display_name': 'JCI Insight', 'issn_l': '2379-3708', 'issn': ['2379-3708'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.57, 'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land'}], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'F32-DK113704'}], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1748636648', 'https://openalex.org/W1931111152', 'https://openalex.org/W1966872601', 'https://openalex.org/W1974867893', 'https://openalex.org/W1985352530', 'https://openalex.org/W1990350445', 'https://openalex.org/W1994173047', 'https://openalex.org/W2022316151', 'https://openalex.org/W2024851295', 'https://openalex.org/W2036082162', 'https://openalex.org/W2036487149', 'https://openalex.org/W2049044905', 'https://openalex.org/W2054830511', 'https://openalex.org/W2056040807', 'https://openalex.org/W2072747772', 'https://openalex.org/W2077971415', 'https://openalex.org/W2091970108', 'https://openalex.org/W2094683694', 'https://openalex.org/W2097016963', 'https://openalex.org/W2097632838', 'https://openalex.org/W2097763382', 'https://openalex.org/W2106816509', 'https://openalex.org/W2116923491', 'https://openalex.org/W2124241212', 'https://openalex.org/W2128607432', 'https://openalex.org/W2142505357', 'https://openalex.org/W2142979249', 'https://openalex.org/W2143536481', 'https://openalex.org/W2146544786', 'https://openalex.org/W2150767656', 'https://openalex.org/W2155846381', 'https://openalex.org/W2156294287', 'https://openalex.org/W2156339883', 'https://openalex.org/W2156469236', 'https://openalex.org/W2158075769', 'https://openalex.org/W2339236494', 'https://openalex.org/W2467091785', 'https://openalex.org/W2530199637', 'https://openalex.org/W2765630251', 'https://openalex.org/W2783761735', 'https://openalex.org/W2794435933', 'https://openalex.org/W2796021090', 'https://openalex.org/W2811123003', 'https://openalex.org/W2892416438'], 'related_works': ['https://openalex.org/W4365479160', 'https://openalex.org/W4229051507', 'https://openalex.org/W2750955292', 'https://openalex.org/W2727209782', 'https://openalex.org/W2352744913', 'https://openalex.org/W2133767155', 'https://openalex.org/W2123476232', 'https://openalex.org/W2090350705', 'https://openalex.org/W2046304440', 'https://openalex.org/W1748636648'], 'abstract_inverted_index': {'The': [0], 'synthesis': [1], 'of': [2, 38, 59, 77, 81, 90, 118, 146], 'lipid': [3], 'and': [4, 24, 50], 'sterol': [5], 'species': [6], 'through': [7], 'de': [8], 'novo': [9], 'lipogenesis': [10], '(DNL)': [11], 'is': [12, 31], 'regulated': [13, 52], 'by': [14, 115], '2': [15], 'functionally': [16], 'overlapping': [17], 'but': [18], 'distinct': [19], 'transcription': [20], 'factors:': [21], 'the': [22, 35, 45, 57, 82, 143], 'SREBPs': [23, 46], 'carbohydrate': [25], 'response': [26], 'element–binding': [27], 'protein': [28], '(ChREBP).': [29], 'ChREBP': [30], 'considered': [32], 'to': [33, 71, 95, 120, 142], 'be': [34, 63, 72], 'dominant': [36], 'regulator': [37, 89], 'DNL': [39, 61, 123], 'in': [40, 53], 'adipose': [41], 'tissue': [42], '(AT);': [43], 'however,': [44], 'are': [47], 'highly': [48], 'expressed': [49], 'robustly': [51], 'adipocytes,': [54], 'suggesting': [55], 'that': [56, 129, 137], 'model': [58, 76], 'AT': [60, 101], 'may': [62], 'incomplete.': [64], 'Here,': [65], 'we': [66, 69, 127], 'describe': [67], 'what': [68], 'believe': [70], 'a': [73, 87, 111, 135], 'new': [74], 'mouse': [75, 148], 'inducible,': [78], 'adipocyte-specific': [79], 'overexpression': [80, 98], 'insulin-induced': [83], 'gene': [84, 103, 124], '1': [85], '(Insig1),': [86], 'negative': [88], 'SREBP': [91], 'transcriptional': [92], 'activity.': [93], 'Contrary': [94], 'convention,': [96], 'Insig1': [97], 'did': [99], 'block': [100], 'lipogenic': [102], 'expression.': [104, 125], 'However,': [105], 'this': [106], 'was': [107], 'immediately': [108], 'met': [109], 'with': [110], 'compensatory': [112], 'mechanism': [113], 'triggered': [114], 'redox': [116], 'activation': [117], 'mTORC1': [119], 'restore': [121], 'SREBP1': [122, 130], 'Thus,': [126], 'demonstrate': [128], 'activity': [131], 'sustains': [132], 'adipocyte': [133], 'lipogenesis,': [134], 'conclusion': [136], 'has': [138], 'been': [139], 'elusive': [140], 'due': [141], 'constitutive': [144], 'nature': [145], 'current': [147], 'models.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2961632360', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 10}], 'updated_date': '2024-09-16T07:32:59.097635', 'created_date': '2019-07-23'}