Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2956123952', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-4661', 'title': 'Abstract 4661: Deciphering the causes of the COSMIC mutational signature 17 by combining pan-cancer data with experimental mouse models', 'display_name': 'Abstract 4661: Deciphering the causes of the COSMIC mutational signature 17 by combining pan-cancer data with experimental mouse models', 'publication_year': 2019, 'publication_date': '2019-07-01', 'ids': {'openalex': 'https://openalex.org/W2956123952', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-4661', 'mag': '2956123952'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-4661', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5083528942', 'display_name': 'Markéta Tomková', 'orcid': 'https://orcid.org/0000-0001-9094-2365'}, 'institutions': [{'id': 'https://openalex.org/I4210106789', 'display_name': 'Ludwig Cancer Research', 'ror': 'https://ror.org/01e473h50', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210106789', 'https://openalex.org/I4210150094']}, {'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Marketa Tomkova', 'raw_affiliation_strings': ['1Ludwig Institute for Cancer Research, University of Oxford, Oxford, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '1Ludwig Institute for Cancer Research, University of Oxford, Oxford, United Kingdom;', 'institution_ids': ['https://openalex.org/I4210106789', 'https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037055010', 'display_name': 'Claire Renard', 'orcid': 'https://orcid.org/0000-0001-6523-3962'}, 'institutions': [{'id': 'https://openalex.org/I42237331', 'display_name': 'Centre International de Recherche sur le Cancer', 'ror': 'https://ror.org/00v452281', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I42237331']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Claire Renard', 'raw_affiliation_strings': ['2Int. Agency for Research on Cancer, Lyon, France;'], 'affiliations': [{'raw_affiliation_string': '2Int. Agency for Research on Cancer, Lyon, France;', 'institution_ids': ['https://openalex.org/I42237331']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077896214', 'display_name': 'Lara Urban', 'orcid': 'https://orcid.org/0000-0002-5445-9314'}, 'institutions': [{'id': 'https://openalex.org/I1303153112', 'display_name': 'European Bioinformatics Institute', 'ror': 'https://ror.org/02catss52', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1303153112', 'https://openalex.org/I4210138560']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Lara Urban', 'raw_affiliation_strings': ['3The European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus Hinxton, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '3The European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus Hinxton, United Kingdom;', 'institution_ids': ['https://openalex.org/I1303153112']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001226082', 'display_name': 'Souad Kolli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I42237331', 'display_name': 'Centre International de Recherche sur le Cancer', 'ror': 'https://ror.org/00v452281', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I42237331']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Souad Kolli', 'raw_affiliation_strings': ['2Int. Agency for Research on Cancer, Lyon, France;'], 'affiliations': [{'raw_affiliation_string': '2Int. Agency for Research on Cancer, Lyon, France;', 'institution_ids': ['https://openalex.org/I42237331']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027145199', 'display_name': 'Maude Ardin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I42237331', 'display_name': 'Centre International de Recherche sur le Cancer', 'ror': 'https://ror.org/00v452281', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I42237331']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Maude Ardin', 'raw_affiliation_strings': ['2Int. Agency for Research on Cancer, Lyon, France;'], 'affiliations': [{'raw_affiliation_string': '2Int. Agency for Research on Cancer, Lyon, France;', 'institution_ids': ['https://openalex.org/I42237331']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006765959', 'display_name': 'Manuraj Pandey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I42237331', 'display_name': 'Centre International de Recherche sur le Cancer', 'ror': 'https://ror.org/00v452281', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I42237331']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Manuraj Pandey', 'raw_affiliation_strings': ['2Int. Agency for Research on Cancer, Lyon, France;'], 'affiliations': [{'raw_affiliation_string': '2Int. Agency for Research on Cancer, Lyon, France;', 'institution_ids': ['https://openalex.org/I42237331']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034008282', 'display_name': 'Maria Zhivagui', 'orcid': 'https://orcid.org/0000-0002-3410-4014'}, 'institutions': [{'id': 'https://openalex.org/I42237331', 'display_name': 'Centre International de Recherche sur le Cancer', 'ror': 'https://ror.org/00v452281', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I42237331']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Maria Zhivagui', 'raw_affiliation_strings': ['2Int. Agency for Research on Cancer, Lyon, France;'], 'affiliations': [{'raw_affiliation_string': '2Int. Agency for Research on Cancer, Lyon, France;', 'institution_ids': ['https://openalex.org/I42237331']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053523685', 'display_name': 'Hana Hušková', 'orcid': 'https://orcid.org/0000-0003-3088-4081'}, 'institutions': [{'id': 'https://openalex.org/I42237331', 'display_name': 'Centre International de Recherche sur le Cancer', 'ror': 'https://ror.org/00v452281', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I42237331']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Hana Huskova', 'raw_affiliation_strings': ['2Int. Agency for Research on Cancer, Lyon, France;'], 'affiliations': [{'raw_affiliation_string': '2Int. Agency for Research on Cancer, Lyon, France;', 'institution_ids': ['https://openalex.org/I42237331']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027951949', 'display_name': 'Magali Olivier', 'orcid': 'https://orcid.org/0000-0002-8202-342X'}, 'institutions': [{'id': 'https://openalex.org/I42237331', 'display_name': 'Centre International de Recherche sur le Cancer', 'ror': 'https://ror.org/00v452281', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I42237331']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Magali Olivier', 'raw_affiliation_strings': ['2Int. Agency for Research on Cancer, Lyon, France;'], 'affiliations': [{'raw_affiliation_string': '2Int. Agency for Research on Cancer, Lyon, France;', 'institution_ids': ['https://openalex.org/I42237331']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080250007', 'display_name': 'Hiroyuki Marusawa', 'orcid': 'https://orcid.org/0000-0002-4286-2712'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroyuki Marusawa', 'raw_affiliation_strings': ['4Graduate School of Medicine, Kyoto University, Kyoto, Japan.'], 'affiliations': [{'raw_affiliation_string': '4Graduate School of Medicine, Kyoto University, Kyoto, Japan.', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030766517', 'display_name': 'Benjamin Schuster‐Böckler', 'orcid': 'https://orcid.org/0000-0002-8892-5133'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}, {'id': 'https://openalex.org/I4210106789', 'display_name': 'Ludwig Cancer Research', 'ror': 'https://ror.org/01e473h50', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210106789', 'https://openalex.org/I4210150094']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Benjamin Schuster-Böckler', 'raw_affiliation_strings': ['1Ludwig Institute for Cancer Research, University of Oxford, Oxford, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '1Ludwig Institute for Cancer Research, University of Oxford, Oxford, United Kingdom;', 'institution_ids': ['https://openalex.org/I40120149', 'https://openalex.org/I4210106789']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5061154196', 'display_name': 'Jiří Zavadil', 'orcid': 'https://orcid.org/0000-0003-0640-5562'}, 'institutions': [{'id': 'https://openalex.org/I42237331', 'display_name': 'Centre International de Recherche sur le Cancer', 'ror': 'https://ror.org/00v452281', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I42237331']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jiri Zavadil', 'raw_affiliation_strings': ['2Int. Agency for Research on Cancer, Lyon, France;'], 'affiliations': [{'raw_affiliation_string': '2Int. Agency for Research on Cancer, Lyon, France;', 'institution_ids': ['https://openalex.org/I42237331']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.086, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.391306, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 61, 'max': 69}, 'biblio': {'volume': '79', 'issue': '13_Supplement', 'first_page': '4661', 'last_page': '4661'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9827, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9804, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/microsatellite-instability', 'display_name': 'Microsatellite Instability', 'score': 0.5671738}, {'id': 'https://openalex.org/keywords/exome', 'display_name': 'Exome', 'score': 0.43772048}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6836586}, {'id': 'https://openalex.org/C2779767149', 'wikidata': 'https://www.wikidata.org/wiki/Q488212', 'display_name': 'Microsatellite instability', 'level': 5, 'score': 0.5671738}, {'id': 'https://openalex.org/C162317418', 'wikidata': 'https://www.wikidata.org/wiki/Q252857', 'display_name': 'Transcriptome', 'level': 4, 'score': 0.52585393}, {'id': 'https://openalex.org/C134305767', 'wikidata': 'https://www.wikidata.org/wiki/Q725508', 'display_name': 'Somatic cell', 'level': 3, 'score': 0.5213024}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.51733845}, {'id': 'https://openalex.org/C178169997', 'wikidata': 'https://www.wikidata.org/wiki/Q2892636', 'display_name': 'Genome instability', 'level': 4, 'score': 0.50416887}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.47224897}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4605251}, {'id': 'https://openalex.org/C10590036', 'wikidata': 'https://www.wikidata.org/wiki/Q417664', 'display_name': 'Exome', 'level': 5, 'score': 0.43772048}, {'id': 'https://openalex.org/C16671776', 'wikidata': 'https://www.wikidata.org/wiki/Q5420592', 'display_name': 'Exome sequencing', 'level': 4, 'score': 0.41561115}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3869614}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.37457377}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.34817618}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.25453973}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2464678}, {'id': 'https://openalex.org/C61320498', 'wikidata': 'https://www.wikidata.org/wiki/Q265193', 'display_name': 'Microsatellite', 'level': 4, 'score': 0.0823009}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0802505}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-4661', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/1', 'score': 0.79, 'display_name': 'No poverty'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3083501552', 'https://openalex.org/W3024198590', 'https://openalex.org/W2772505697', 'https://openalex.org/W2484239316', 'https://openalex.org/W2400191746', 'https://openalex.org/W2106924416', 'https://openalex.org/W2093932542', 'https://openalex.org/W2084396715', 'https://openalex.org/W2043256480', 'https://openalex.org/W1983406990'], 'abstract_inverted_index': {'Abstract': [0], 'Gastric': [1], 'and': [2, 27, 41, 95, 115, 136, 183, 193, 202, 214, 218, 233, 239, 253, 308, 317, 340, 370, 380, 409, 413], 'esophageal': [3], 'adenocarcinomas': [4], '(G/EAC)': [5], 'exhibit': [6], 'a': [7, 28, 48, 68, 357], 'characteristic': [8], 'pattern': [9], 'of': [10, 50, 71, 99, 125, 141, 148, 176, 199, 209, 290, 356, 366, 401, 445, 462], 'somatic': [11], 'variants,': [12], 'known': [13], 'as': [14, 118, 120, 222, 270, 272], 'signature': [15, 72, 84, 110, 161, 177, 200, 230, 246, 277, 281, 315, 318, 333, 338, 348, 362, 384, 402, 449], '17.': [16, 385], 'Signature': [17, 35], '17': [18, 36, 85, 111, 162, 178, 231, 247, 278, 316, 334, 363, 450], 'associates': [19], 'with': [20, 38, 47, 166, 280, 344, 383, 404, 455], 'high': [21], 'mutation': [22], 'burden,': [23], 'elevated': [24], 'neoantigen': [25], 'levels': [26], 'potential': [29, 405], 'sensitivity': [30], 'to': [31, 78, 105, 160, 168, 259, 287, 301, 395], 'cell': [32, 128, 206], 'cycle': [33], 'inhibitors.': [34], 'correlates': [37], 'poor': [39], 'survival,': [40, 238], 'is': [42, 67, 284], 'increased': [43], 'in': [44, 87, 96, 187, 249, 261, 265, 273, 313, 320, 332, 337, 347, 364, 371], 'cancer': [45, 411], 'patients': [46], 'history': [49], 'the': [51, 107, 174, 197, 255, 293, 324, 367, 388, 397, 443, 446, 463], 'common': [52], 'pre-malignant': [53], 'lesion': [54], 'called': [55], 'Barrett’s': [56, 234], 'esophagus.': [57], 'We': [58, 225, 374], 'recently': [59], 'showed': [60, 341], 'that': [61, 295], 'oxidative': [62, 288, 297], 'damage': [63, 212, 289, 299], 'during': [64], 'DNA': [65, 211, 298], 'replication': [66, 181, 306, 345], 'likely': [69, 285], 'source': [70], '17;': [73], 'however': [74], 'this': [75], 'hypothesis': [76, 294], 'remains': [77], 'be': [79], 'validated.': [80], 'Intriguingly,': [81], 'we': [82, 103, 172], 'observe': [83], 'arising': [86], 'clonally': [88], 'expanded': [89], 'primary': [90, 408], 'mouse': [91, 97, 457], 'cells': [92, 192], '(Hupki': [93], 'MEF)': [94], 'models': [98, 392, 458], 'liver': [100], 'cancer.': [101], 'Here,': [102], 'aim': [104], 'identify': [106, 396], 'mechanisms': [108], 'underlying': [109, 361], 'by': [112, 451], 'mining': [113], 'TCGA': [114], 'ICGC': [116], 'data,': [117], 'well': [119, 271], 'generating': [121], 'genome-wide': [122], 'molecular': [123, 381], 'profiles': [124], 'relevant': [126, 223], 'experimental': [127, 456], 'systems.': [129, 373], 'Mutational': [130], 'signatures': [131], 'were': [132, 311], 'extracted': [133], 'from': [134, 151, 190], 'exome': [135], 'whole-genome': [137], 'sequencing': [138], '(WGS)': [139], 'data': [140, 150, 189, 244, 454], 'over': [142], '460': [143], 'G/EAC': [144, 194], 'tumors.': [145, 263], 'Pathway': [146], 'analysis': [147], 'RNA-seq': [149], 'matching': [152], 'samples': [153], 'was': [154, 163], 'performed': [155], 'using': [156, 387], 'NIH': [157], 'DAVID.': [158], 'Exposure': [159], 'next': [164], 'assessed': [165], 'regards': [167], 'clinico-pathologic': [169], 'data.': [170], 'Lastly,': [171], 'compared': [173], 'asymmetry': [175, 331], 'mutations': [179], 'around': [180], 'origins': [182], 'early/late': [184], 'replicating': [185], 'regions': [186, 252], 'WGS': [188, 243], 'MEF': [191, 242, 268, 326], 'cancers.': [195, 304], 'Comparing': [196], 'transcriptomes': [198], '17-high': [201], '-low': [203], 'tumors': [204], 'implicated': [205], 'proliferation,': [207], 'regulation': [208], 'apoptosis,': [210], 'response': [213], 'repair,': [215], 'oxidoreductase': [216], 'activity': [217, 360], 'gastric': [219], 'acid': [220], 'secretion': [221], 'pathways.': [224], 'found': [226], 'positive': [227], 'associations': [228, 382], 'between': [229], 'intensity': [232], 'esophagus': [235], 'history,': [236], 'poorer': [237], 'microsatellite': [240], 'instability.': [241], 'revealed': [245], 'enrichment': [248], 'late-replicating': [250], 'genomic': [251], 'on': [254], 'lagging': [256], 'strand,': [257], 'analogous': [258], 'observations': [260], 'human': [262, 303], 'Importantly,': [264], 'all': [266], 'cultured': [267], 'clones': [269, 327], 'most': [274], 'EAC': [275, 321], 'genomes,': [276, 322], 'co-occurred': [279], '18': [282, 319], 'which': [283], 'linked': [286], 'DNA,': [291], 'supporting': [292], 'inflammation-driven': [296], 'leads': [300], 'these': [302], 'The': [305], 'strand': [307, 330], 'timing': [309, 346], 'asymmetries': [310], 'significant': [312, 329, 342], 'both': [314], 'while': [323], 'Hupki': [325], 'exhibited': [328], 'but': [335], 'not': [336], '18,': [339], 'correlation': [343], '18.': [349], 'Collectively,': [350], 'our': [351], 'results': [352], 'elucidate': [353], 'new': [354], 'features': [355], 'modifiable': [358], 'mutagenic': [359], 'cancers': [365], 'esophagus,': [368], 'stomach,': [369], 'model': [372], 'have': [375], 'also': [376], 'identified': [377], 'novel': [378], 'clinical': [379], 'Investigations': [386], 'reported': [389], 'innovative': [390], 'cell-based': [391], 'will': [393], 'help': [394], 'precise': [398], 'mechanistic': [399], 'basis': [400], '17,': [403], 'implications': [406], 'for': [407, 466], 'secondary': [410], 'prevention': [412], 'personalized': [414], 'therapy.': [415], 'Citation': [416], 'Format:': [417], 'Marketa': [418], 'Tomkova,': [419], 'Claire': [420], 'Renard,': [421], 'Lara': [422], 'Urban,': [423], 'Souad': [424], 'Kolli,': [425], 'Maude': [426], 'Ardin,': [427], 'Manuraj': [428], 'Pandey,': [429], 'Maria': [430], 'Zhivagui,': [431], 'Hana': [432], 'Huskova,': [433], 'Magali': [434], 'Olivier,': [435], 'Hiroyuki': [436], 'Marusawa,': [437], 'Benjamin': [438], 'Schuster-Böckler,': [439], 'Jiri': [440], 'Zavadil.': [441], 'Deciphering': [442], 'causes': [444], 'COSMIC': [447], 'mutational': [448], 'combining': [452], 'pan-cancer': [453], '[abstract].': [459], 'In:': [460], 'Proceedings': [461], 'American': [464], 'Association': [465], 'Cancer': [467, 481], 'Research': [468], 'Annual': [469], 'Meeting': [470], '2019;': [471], '2019': [472], 'Mar': [473], '29-Apr': [474], '3;': [475], 'Atlanta,': [476], 'GA.': [477], 'Philadelphia': [478], '(PA):': [479], 'AACR;': [480], 'Res': [482], '2019;79(13': [483], 'Suppl):Abstract': [484], 'nr': [485], '4661.': [486]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2956123952', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-24T07:59:17.304973', 'created_date': '2019-07-12'}