Publication Information

{'id': 'https://openalex.org/W2956118764', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-300', 'title': 'Abstract 300: A new combination therapy to treat metastatic breast cancer', 'display_name': 'Abstract 300: A new combination therapy to treat metastatic breast cancer', 'publication_year': 2019, 'publication_date': '2019-07-01', 'ids': {'openalex': 'https://openalex.org/W2956118764', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-300', 'mag': '2956118764'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-300', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042608851', 'display_name': 'Bahram Sharif-Askari', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Bahram Sharif-Askari', 'raw_affiliation_strings': ['McGill Univ. Lady Davis Inst., Montreal, Quebec, Canada.'], 'affiliations': [{'raw_affiliation_string': 'McGill Univ. Lady Davis Inst., Montreal, Quebec, Canada.', 'institution_ids': ['https://openalex.org/I5023651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005764534', 'display_name': 'Raquel Aloyz', 'orcid': 'https://orcid.org/0000-0002-6812-497X'}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Raquel Aloyz', 'raw_affiliation_strings': ['McGill Univ. Lady Davis Inst., Montreal, Quebec, Canada.'], 'affiliations': [{'raw_affiliation_string': 'McGill Univ. Lady Davis Inst., Montreal, Quebec, Canada.', 'institution_ids': ['https://openalex.org/I5023651']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110056997', 'display_name': 'Lawrence Panasci', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Lawrence Panasci', 'raw_affiliation_strings': ['McGill Univ. Lady Davis Inst., Montreal, Quebec, Canada.'], 'affiliations': [{'raw_affiliation_string': 'McGill Univ. Lady Davis Inst., Montreal, Quebec, Canada.', 'institution_ids': ['https://openalex.org/I5023651']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.117, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.497612, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 61, 'max': 69}, 'biblio': {'volume': '79', 'issue': '13_Supplement', 'first_page': '300', 'last_page': '300'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12829', 'display_name': 'Advanced Breast Cancer Therapies', 'score': 0.9805, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11752', 'display_name': 'Cancer Treatment and Pharmacology', 'score': 0.9774, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vinorelbine', 'display_name': 'Vinorelbine', 'score': 0.9254739}, {'id': 'https://openalex.org/keywords/eribulin', 'display_name': 'Eribulin', 'score': 0.85192263}, {'id': 'https://openalex.org/keywords/vinca-alkaloid', 'display_name': 'Vinca alkaloid', 'score': 0.6766341}, {'id': 'https://openalex.org/keywords/olaparib', 'display_name': 'Olaparib', 'score': 0.6675539}, {'id': 'https://openalex.org/keywords/microtubule-polymerization', 'display_name': 'Microtubule polymerization', 'score': 0.5984343}, {'id': 'https://openalex.org/keywords/vinca', 'display_name': 'Vinca', 'score': 0.5143748}, {'id': 'https://openalex.org/keywords/mechanism-of-action', 'display_name': 'Mechanism of Action', 'score': 0.44160435}], 'concepts': [{'id': 'https://openalex.org/C2780350996', 'wikidata': 'https://www.wikidata.org/wiki/Q420532', 'display_name': 'Vinorelbine', 'level': 4, 'score': 0.9254739}, {'id': 'https://openalex.org/C2776387010', 'wikidata': 'https://www.wikidata.org/wiki/Q408717', 'display_name': 'Eribulin', 'level': 5, 'score': 0.85192263}, {'id': 'https://openalex.org/C2776553716', 'wikidata': 'https://www.wikidata.org/wiki/Q3559405', 'display_name': 'Vinca alkaloid', 'level': 5, 'score': 0.6766341}, {'id': 'https://openalex.org/C2779962180', 'wikidata': 'https://www.wikidata.org/wiki/Q7083106', 'display_name': 'Olaparib', 'level': 5, 'score': 0.6675539}, {'id': 'https://openalex.org/C2909009945', 'wikidata': 'https://www.wikidata.org/wiki/Q189933', 'display_name': 'Microtubule polymerization', 'level': 4, 'score': 0.5984343}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.56424594}, {'id': 'https://openalex.org/C2777096885', 'wikidata': 'https://www.wikidata.org/wiki/Q220925', 'display_name': 'Vinca', 'level': 2, 'score': 0.5143748}, {'id': 'https://openalex.org/C2776120743', 'wikidata': 'https://www.wikidata.org/wiki/Q3271540', 'display_name': 'Mechanism of action', 'level': 3, 'score': 0.44160435}, {'id': 'https://openalex.org/C84425145', 'wikidata': 'https://www.wikidata.org/wiki/Q422492', 'display_name': 'Tubulin', 'level': 3, 'score': 0.43418646}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.42568892}, {'id': 'https://openalex.org/C93304396', 'wikidata': 'https://www.wikidata.org/wiki/Q14763008', 'display_name': 'Mitosis', 'level': 2, 'score': 0.41282165}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.40826294}, {'id': 'https://openalex.org/C20418707', 'wikidata': 'https://www.wikidata.org/wiki/Q189933', 'display_name': 'Microtubule', 'level': 2, 'score': 0.36853486}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.36706555}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.36272824}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.36217573}, {'id': 'https://openalex.org/C182979987', 'wikidata': 'https://www.wikidata.org/wiki/Q3907241', 'display_name': 'Poly ADP ribose polymerase', 'level': 4, 'score': 0.3588034}, {'id': 'https://openalex.org/C2775930923', 'wikidata': 'https://www.wikidata.org/wiki/Q12859063', 'display_name': 'Metastatic breast cancer', 'level': 4, 'score': 0.3502041}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31238562}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.22105119}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.20775619}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.18955186}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.16999471}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1547274}, {'id': 'https://openalex.org/C2779429289', 'wikidata': 'https://www.wikidata.org/wiki/Q408977', 'display_name': 'Vincristine', 'level': 4, 'score': 0.144369}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.1427035}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.11298257}, {'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.059627324}, {'id': 'https://openalex.org/C2776755627', 'wikidata': 'https://www.wikidata.org/wiki/Q408524', 'display_name': 'Cyclophosphamide', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-300', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.81, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4299333187', 'https://openalex.org/W2607999755', 'https://openalex.org/W2416587526', 'https://openalex.org/W2322965840', 'https://openalex.org/W2155176893', 'https://openalex.org/W2080201768', 'https://openalex.org/W2054917972', 'https://openalex.org/W2015530412', 'https://openalex.org/W1982103277', 'https://openalex.org/W1669628807'], 'abstract_inverted_index': {'Abstract': [0], 'Poly': [1], '(ADP-ribose)': [2], 'polymerase': [3], '(PARP)': [4], 'resulting': [5, 182], 'poly': [6], '(ADP-ribosyl)ation': [7], 'is': [8, 40, 45, 147], 'an': [9, 152], 'early': [10], 'player': [11], 'in': [12, 35, 42, 53, 67, 133, 183, 203, 218, 224, 289], 'modification': [13], 'of': [14, 55, 72, 77, 81, 111, 127, 159, 169, 186, 195, 209, 216, 222, 241, 292, 303, 309, 322, 349], 'proteins': [15], 'detected': [16], 'at': [17, 251], 'single': [18], 'strand': [19, 23], 'breaks': [20, 24], 'and': [21, 31, 75, 86, 92, 116, 123, 234, 257, 296], 'double': [22], 'contributing': [25], 'to': [26, 70, 103, 106, 173, 176, 213, 220, 264, 312, 341], 'DNA': [27, 129], 'repair.': [28], 'PARP1,': [29], '2': [30, 82], '3': [32], 'are': [33], 'involved': [34, 132], 'this': [36, 134], 'process.': [37], 'However,': [38], 'PARP3': [39, 83, 119, 247, 304, 324], 'unique': [41, 157, 178], 'that,': [43], 'it': [44, 161], 'also': [46, 117], 'required': [47], 'for': [48, 239, 326, 353], 'efficient': [49], 'mitotic': [50, 57, 121, 313], 'progression,': [51], 'specifically': [52], 'stabilization': [54], 'the': [56, 73, 184, 210, 231, 290, 307, 350], 'spindle.': [58], 'The': [59, 301], 'vinca': [60], 'alkaloids': [61], 'such': [62], 'as': [63, 273], 'vinorelbine,': [64], 'arrest': [65], 'cells': [66, 311], 'metaphase': [68], 'due': [69], 'inhibition': [71, 302], 'assembly': [74], 'dynamics': [76, 164], 'microtubules.': [78], 'Nontoxic': [79], 'concentrations': [80], 'inhibitors,': [84], 'ME-0328': [85], 'olaparib,': [87], 'sensitized': [88, 250], 'various': [89], 'her-2': [90, 255], 'negative': [91, 94, 256, 259, 295, 298], 'triple': [93, 258, 294], 'breast': [95, 228, 245, 260, 299, 344], 'cancer': [96, 229, 261, 345], 'cell': [97, 262], 'lines': [98, 263], 'greater': [99], 'than': [100], 'or': [101], 'equal': [102], '10': [104], 'fold': [105, 254], 'vinorelbine': [107, 278], 'associated': [108], 'with': [109, 114, 155, 193, 243, 271, 277], 'potentiation': [110], 'vinorelbine’s': [112], 'interaction': [113], 'tubulin': [115, 181, 196], 'vinorelbine-induced': [118], 'inhibition,': [120], 'arrest,': [122], 'apoptosis': [124], 'without': [125, 189], 'evidence': [126], 'a': [128, 148, 156, 166, 177, 286], 'repair': [130], 'mechanism': [131, 158, 168], 'sensitization': [135], '(Sharif-Askari': [136], 'B': [137, 150], 'et': [138], 'al.': [139], 'Breast': [140], 'Cancer': [141, 354, 368], 'Res': [142, 369], 'Treat.': [143], '2018': [144], 'Nov;172(1):23-32).': [145], 'Eribulin': [146], 'Halichondrin': [149], 'analogue,': [151], 'antitubulin': [153], 'drug,': [154], 'action;': [160], 'inhibits': [162], 'microtubule': [163, 187], 'via': [165], 'novel': [167], 'action': [170], 'which': [171], 'seems': [172], 'involve': [174], 'binding': [175], 'site': [179], 'on': [180], 'suppression': [185], 'polymerization': [188], 'affecting': [190], 'depolymerization': [191], 'along': [192], 'sequestration': [194], 'into': [197], 'nonfunctional': [198], 'aggregate.': [199], 'After': [200], 'impressive': [201], 'results': [202, 318], 'phase': [204], 'III': [205], 'trials': [206, 212], '(including': [207], 'one': [208], 'rare': [211], 'show': [214], 'prolongation': [215], 'survival': [217], 'comparison': [219], 'standard': [221], 'care': [223], 'heavily': [225], 'pretreated': [226], 'metastatic': [227, 244, 293, 343], 'patients)': [230], 'U.S.': [232], 'Food': [233], 'Drug': [235], 'Administration': [236], 'approved': [237], 'eribulin': [238, 272], 'treatment': [240, 291], 'patients': [242], 'cancer.': [246, 300], 'inhibitors': [248, 325], 'again': [249], 'least': [252], '5': [253], 'eribulin.': [265], 'We': [266], 'will': [267], 'do': [268], 'similar': [269], 'studies': [270, 283], 'we': [274], 'have': [275], 'done': [276], 'including': [279], 'in-vivo': [280], 'studies.': [281], 'These': [282], 'could': [284], 'define': [285], 'new': [287, 338], 'therapy': [288, 340], 'ER+/her-2': [297], 'may': [305], 'increase': [306], 'sensitivity': [308], 'tumor': [310], 'spindle': [314], 'poison': [315], 'chemotherapies.': [316], 'Our': [317], 'should': [319], 'stimulate': [320], 'development': [321], 'specific': [323], 'clinical': [327], 'use.': [328], 'Citation': [329], 'Format:': [330], 'Bahram': [331], 'Sharif-Askari,': [332], 'Raquel': [333], 'Aloyz,': [334], 'Lawrence': [335], 'Panasci.': [336], 'A': [337], 'combination': [339], 'treat': [342], '[abstract].': [346], 'In:': [347], 'Proceedings': [348], 'American': [351], 'Association': [352], 'Research': [355], 'Annual': [356], 'Meeting': [357], '2019;': [358], '2019': [359], 'Mar': [360], '29-Apr': [361], '3;': [362], 'Atlanta,': [363], 'GA.': [364], 'Philadelphia': [365], '(PA):': [366], 'AACR;': [367], '2019;79(13': [370], 'Suppl):Abstract': [371], 'nr': [372], '300.': [373]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2956118764', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-12T17:34:48.891154', 'created_date': '2019-07-12'}