Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2956001001', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-1493', 'title': 'Abstract 1493: Therapeutic efficacy and tolerability of combined immune checkpoint blockade in metastatic melanoma patients is influenced by the gut microbiome', 'display_name': 'Abstract 1493: Therapeutic efficacy and tolerability of combined immune checkpoint blockade in metastatic melanoma patients is influenced by the gut microbiome', 'publication_year': 2019, 'publication_date': '2019-07-01', 'ids': {'openalex': 'https://openalex.org/W2956001001', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-1493', 'mag': '2956001001'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-1493', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5082545687', 'display_name': 'Vancheswaran Gopalakrishnan', 'orcid': 'https://orcid.org/0000-0002-8704-035X'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vancheswaran Gopalakrishnan', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018196946', 'display_name': 'Miles C. Andrews', 'orcid': 'https://orcid.org/0000-0003-1231-8641'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Miles Andrews', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062379830', 'display_name': 'Wei-Shen Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2613432', 'display_name': 'University of South Florida', 'ror': 'https://ror.org/032db5x82', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2613432']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei-Shen Chen', 'raw_affiliation_strings': ['2University of South Florida Morsani College of Medicine, Tampa, FL;'], 'affiliations': [{'raw_affiliation_string': '2University of South Florida Morsani College of Medicine, Tampa, FL;', 'institution_ids': ['https://openalex.org/I2613432']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022333320', 'display_name': 'Christine N. Spencer', 'orcid': 'https://orcid.org/0000-0002-1304-4390'}, 'institutions': [{'id': 'https://openalex.org/I4210109986', 'display_name': 'Parker Institute for Cancer Immunotherapy', 'ror': 'https://ror.org/0184qbg02', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210109986']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christine Spencer', 'raw_affiliation_strings': ['3Parker Institute for Cancer Immunotherapy, San Francisco, CA;'], 'affiliations': [{'raw_affiliation_string': '3Parker Institute for Cancer Immunotherapy, San Francisco, CA;', 'institution_ids': ['https://openalex.org/I4210109986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034269049', 'display_name': 'Luis M. Vence', 'orcid': 'https://orcid.org/0000-0003-3441-4095'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Luis Vence', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088889988', 'display_name': 'Alexandre Reuben', 'orcid': 'https://orcid.org/0000-0003-4510-0382'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexandre Reuben', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071770314', 'display_name': 'Zachary A. Cooper', 'orcid': 'https://orcid.org/0000-0003-1059-0940'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Zachary A. Cooper', 'raw_affiliation_strings': ['4MedImmune, Gaithersburg, MD;'], 'affiliations': [{'raw_affiliation_string': '4MedImmune, Gaithersburg, MD;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036869327', 'display_name': 'Peter A. Prieto', 'orcid': 'https://orcid.org/0000-0003-3792-7355'}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter A. Prieto', 'raw_affiliation_strings': ['5University of Rochester, Rochester, NY;'], 'affiliations': [{'raw_affiliation_string': '5University of Rochester, Rochester, NY;', 'institution_ids': ['https://openalex.org/I5388228']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067831105', 'display_name': 'Michael T. Tetzlaff', 'orcid': 'https://orcid.org/0000-0001-7899-4138'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael T. Tetzlaff', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056363417', 'display_name': 'MA Abdul Wadud Khan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'MA Abdul Wadud Khan', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050445982', 'display_name': 'Alexander J. Lazar', 'orcid': 'https://orcid.org/0000-0002-6395-4499'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexander Lazar', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005860428', 'display_name': 'Courtney W. Hudgens', 'orcid': 'https://orcid.org/0000-0001-8312-7485'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Courtney W. Hudgens', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008839819', 'display_name': 'Lauren E. Haydu', 'orcid': 'https://orcid.org/0000-0002-6360-0199'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lauren E. Haydu', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000768609', 'display_name': 'Hussein A. Tawbi', 'orcid': 'https://orcid.org/0000-0003-1942-851X'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hussein A. Tawbi', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102918494', 'display_name': 'Patrick Hwu', 'orcid': 'https://orcid.org/0000-0003-0554-2856'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patrick Hwu', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104110089', 'display_name': 'Wen‐Jen Hwu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wen-Jen Hwu', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029017725', 'display_name': 'Rodabe N. Amaria', 'orcid': 'https://orcid.org/0000-0001-6876-278X'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rodabe N. Amaria', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036227254', 'display_name': 'Elizabeth M. Burton', 'orcid': 'https://orcid.org/0000-0002-3424-4922'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth M. Burton', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063956615', 'display_name': 'Scottt E. Woodman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Scottt E. Woodman', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030834372', 'display_name': 'Adi Diab', 'orcid': 'https://orcid.org/0000-0002-0153-0244'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Adi Diab', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035218748', 'display_name': 'Sapna P. Patel', 'orcid': 'https://orcid.org/0000-0003-1339-1517'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sapna P. Patel', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5114002330', 'display_name': 'Isabella C. Glitza', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Isabella C. Glitza', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100434755', 'display_name': 'Jianhua Zhang', 'orcid': 'https://orcid.org/0000-0001-5412-9860'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jianhua Zhang', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026573989', 'display_name': 'Joseph F. Petrosino', 'orcid': 'https://orcid.org/0000-0002-4046-6898'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph Petrosino', 'raw_affiliation_strings': ['6Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': '6Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025089795', 'display_name': 'Robert R. Jenq', 'orcid': 'https://orcid.org/0000-0002-5434-439X'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert R. Jenq', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048327749', 'display_name': 'Michael A. Davies', 'orcid': 'https://orcid.org/0000-0002-0977-0912'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael A. Davies', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081648218', 'display_name': 'Jeffrey E. Gershenwald', 'orcid': 'https://orcid.org/0000-0003-4519-5369'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey E. Gershenwald', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071033599', 'display_name': 'Padmanee Sharma', 'orcid': 'https://orcid.org/0000-0003-4658-055X'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Padmanee Sharma', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047117233', 'display_name': 'James P. Allison', 'orcid': 'https://orcid.org/0000-0001-8980-5697'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James P. Allison', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067102201', 'display_name': 'P. Andrew Futreal', 'orcid': 'https://orcid.org/0000-0001-8663-2671'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew Futreal', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035427219', 'display_name': 'Jennifer A. Wargo', 'orcid': 'https://orcid.org/0000-0003-3438-7576'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer A. Wargo', 'raw_affiliation_strings': ['1UT MD Anderson Cancer Center, Houston, TX;'], 'affiliations': [{'raw_affiliation_string': '1UT MD Anderson Cancer Center, Houston, TX;', 'institution_ids': ['https://openalex.org/I1343551460']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.246, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.459343, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 74, 'max': 77}, 'biblio': {'volume': '79', 'issue': '13_Supplement', 'first_page': '1493', 'last_page': '1493'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10066', 'display_name': 'Gut microbiota and health', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10066', 'display_name': 'Gut microbiota and health', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/immune-checkpoint', 'display_name': 'Immune checkpoint', 'score': 0.5308911}], 'concepts': [{'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.6058874}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.5729498}, {'id': 'https://openalex.org/C2780057760', 'wikidata': 'https://www.wikidata.org/wiki/Q13896859', 'display_name': 'Pembrolizumab', 'level': 4, 'score': 0.56072676}, {'id': 'https://openalex.org/C2780851360', 'wikidata': 'https://www.wikidata.org/wiki/Q21686041', 'display_name': 'Immune checkpoint', 'level': 4, 'score': 0.5308911}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.47642455}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.46714327}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.44191548}, {'id': 'https://openalex.org/C143121216', 'wikidata': 'https://www.wikidata.org/wiki/Q1330402', 'display_name': 'Microbiome', 'level': 2, 'score': 0.4368646}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4220633}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.4175333}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4146132}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4021181}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.37897003}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.33759287}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.23930162}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.13994369}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-1493', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.59, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4292373623', 'https://openalex.org/W3215044659', 'https://openalex.org/W3158438576', 'https://openalex.org/W3134459122', 'https://openalex.org/W2970048128', 'https://openalex.org/W2903811712', 'https://openalex.org/W2899426010', 'https://openalex.org/W2795035720', 'https://openalex.org/W2777867648', 'https://openalex.org/W2607780130'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'The': [2, 167], 'gut': [3, 169, 351, 396, 505], 'microbiome': [4, 352, 397, 506], 'is': [5, 60, 501], 'increasingly': [6], 'being': [7], 'recognized': [8], 'as': [9, 90, 107, 398], 'a': [10, 76, 189, 323, 346, 391, 400], 'strong': [11], 'modulator': [12], 'of': [13, 51, 69, 78, 142, 180, 185, 191, 195, 206, 228, 242, 266, 345, 377, 492, 510], 'anti-PD1': [14], 'based': [15, 102, 219], 'cancer': [16], 'immunotherapy.': [17], 'Compelling': [18], 'evidence': [19], 'demonstrates': [20], 'differential': [21, 309], 'bacterial': [22, 310], 'enrichment': [23, 241, 311], 'and': [24, 38, 106, 151, 182, 235, 246, 252, 286, 294, 320, 322, 341, 353, 369, 382, 403, 490], 'diversity': [25], 'in': [26, 48, 172, 250, 255, 273, 292, 364, 370, 497], 'responders': [27], '(R)': [28], 'versus': [29, 276], 'non-responders': [30], '(NR),': [31], 'mediated': [32], 'by': [33, 126, 136, 147, 156, 193, 231, 308, 326, 503], 'profound': [34], 'influences': [35], 'on': [36, 103, 161, 220, 337], 'systemic': [37], 'anti-tumor': [39], 'immune': [40, 55, 122, 144, 302, 380, 494], 'infiltrates.': [41], 'However,': [42], 'this': [43], 'has': [44], 'not': [45], 'been': [46], 'studied': [47], 'the': [49, 207, 262, 267, 280, 343, 350, 395, 504, 511], 'setting': [50], 'treatment': [52], 'with': [53, 62, 80, 177, 202, 258, 300, 379], 'combined': [54, 493], 'checkpoint': [56, 357, 495], 'blockade': [57, 358, 496], '(CICB),': [58], 'which': [59], 'associated': [61], 'superior': [63], 'response': [64, 213], 'rates,': [65], 'but': [66], 'higher': [67, 112, 272], 'rates': [68], 'potentially': [70], 'debilitating': [71], 'toxicities.': [72], 'Methods:': [73], 'We': [74], 'assembled': [75], 'cohort': [77], 'patients': [79, 87, 174, 500], 'metastatic': [81, 498], 'melanoma': [82, 499], 'receiving': [83], 'CICB': [84], '(n=54).': [85], 'All': [86], 'were': [88, 134, 159, 217, 225, 290], 'classified': [89], 'R': [91, 274], '(n=31,': [92], 'CR': [93], '+': [94, 100], 'PR)': [95], 'or': [96, 111, 115, 214, 328], 'NR': [97, 277], '(n=23,': [98], 'SD': [99], 'PD)': [101], 'RECIST': [104], 'v1.1,': [105], 'having': [108], 'grade': [109, 118], '3': [110, 119], '(T;': [113], 'n=29),': [114], 'less': [116], 'than': [117], '(NT;': [120], 'n=25)': [121], 'related': [123], 'adverse': [124], 'event(s)': [125], 'NCI': [127], 'CTCAE': [128], '4.0': [129], 'criteria.': [130], 'Baseline': [131], 'stool': [132], 'samples': [133], 'characterized': [135], '16S': [137], 'rRNA': [138], 'sequencing.': [139], 'Correlative': [140], 'analyses': [141, 299], 'peripheral': [143], 'cell': [145, 154, 303], 'populations': [146], 'flow': [148], 'cytometry': [149], '(n=12)': [150, 158], 'circulating': [152, 301], 'T': [153, 293], 'repertoire': [155, 331], 'TCR-sequencing': [157], 'done': [160], 'matched': [162, 366], 'pre-treatment': [163], 'blood': [164], 'samples.': [165], 'Results:': [166], 'overall': [168, 316], 'microbial': [170], 'landscape': [171], 'these': [173, 388], 'was': [175, 270], 'varied': [176], 'high': [178, 327], 'abundance': [179, 265, 319], 'Bacteroidales': [181], 'Clostridiales.': [183], 'Ordination': [184], 'beta-diversity': [186], 'distances': [187], 'revealed': [188, 239, 305], 'lack': [190], 'clustering': [192, 324], 'subtype': [194], 'primary': [196], 'tumor': [197, 208], '(uveal,': [198], 'mucosal,': [199], 'cutaneous)': [200], 'consistent': [201], 'no': [203, 211], 'significant': [204], 'effect': [205, 325], 'histology.': [209], 'While': [210], 'apparent': [212], 'toxicity': [215], 'associations': [216, 307], 'evident': [218], 'diversity,': [221], 'notable': [222], 'compositional': [223], 'differences': [224], 'appreciated.': [226], 'Comparison': [227], 'relative': [229, 264], 'abundances': [230], 'LEfSe': [232], '(LDA>2,': [233], 'p<0.05),': [234], 'pairwise': [236], 'Mann-Whitney': [237], 'tests': [238], 'an': [240], 'Bacteroides': [243, 283], 'stercoris': [244], '(p=0.03),': [245], 'Parabacteroides': [247], 'distasonis': [248], '(p=0.04)': [249], 'R,': [251], 'Lactobacillales': [253], '(p=0.005)': [254], 'NR.': [256], 'Consistent': [257], 'our': [259, 338], 'prior': [260, 339], 'findings,': [261], 'median': [263], 'order': [268], 'Clostridiales': [269], 'again': [271], '(0.34)': [275], '(0.26).': [278], 'On': [279], 'other': [281], 'hand,': [282], 'intestinalis': [284], '(p=0.01)': [285], 'Anaerotignum': [287], 'lactatifermentans': [288], '(p=0.006)': [289], 'enriched': [291], 'NT,': [295], 'respectively.': [296], 'Importantly,': [297], 'correlative': [298], 'subsets': [304], 'distinct': [306], '(including': [312], 'positive': [313], 'correlations': [314], 'between': [315, 349], 'CD8+': [317], 'T-cell': [318, 330], 'R-taxa),': [321], 'low': [329], 'entropy.': [332], 'Conclusion:': [333], 'These': [334], 'findings': [335], 'build': [336], 'work': [340], 'support': [342, 390], 'notion': [344], 'close': [347], 'link': [348], 'therapeutic': [354, 404], 'outcomes': [355], 'to': [356, 373, 383], 'therapy.': [359], 'Extensive': [360], 'studies': [361], 'are': [362], 'underway': [363], 'both': [365, 399], 'human': [367], 'biospecimens': [368], 'pre-clinical': [371], 'models': [372], 'further': [374], 'understand': [375], 'mechanisms': [376], 'interactions': [378], 'markers,': [381], 'establish': [384], 'causality.': [385], 'Taken': [386], 'together,': [387], 'data': [389], 'critical': [392], 'role': [393], 'for': [394, 514], 'predictive': [401], 'tool': [402], 'target.': [405], 'Citation': [406], 'Format:': [407], 'Vancheswaran': [408], 'Gopalakrishnan,': [409], 'Miles': [410], 'Andrews,': [411], 'Wei-Shen': [412], 'Chen,': [413], 'Christine': [414], 'Spencer,': [415], 'Luis': [416], 'Vence,': [417], 'Alexandre': [418], 'Reuben,': [419], 'Zachary': [420], 'A.': [421, 424, 442, 473, 486], 'Cooper,': [422], 'Peter': [423], 'Prieto,': [425], 'Michael': [426, 472], 'T.': [427], 'Tetzlaff,': [428], 'MA': [429], 'Abdul': [430], 'Wadud': [431], 'Khan,': [432], 'Alexander': [433], 'Lazar,': [434], 'Courtney': [435], 'W.': [436], 'Hudgens,': [437], 'Lauren': [438], 'E.': [439, 455, 476], 'Haydu,': [440], 'Hussein': [441], 'Tawbi,': [443], 'Patrick': [444], 'Hwu,': [445, 447], 'Wen-Jen': [446], 'Rodabe': [448], 'N.': [449], 'Amaria,': [450], 'Elizabeth': [451], 'M.': [452], 'Burton,': [453], 'Scottt': [454], 'Woodman,': [456], 'Adi': [457], 'Diab,': [458], 'Sapna': [459], 'P.': [460, 481], 'Patel,': [461], 'Isabella': [462], 'C.': [463], 'Glitza,': [464], 'Jianhua': [465], 'Zhang,': [466], 'Joseph': [467], 'Petrosino,': [468], 'Robert': [469], 'R.': [470], 'Jenq,': [471], 'Davies,': [474], 'Jeffrey': [475], 'Gershenwald,': [477], 'Padmanee': [478], 'Sharma,': [479], 'James': [480], 'Allison,': [482], 'Andrew': [483], 'Futreal,': [484], 'Jennifer': [485], 'Wargo.': [487], 'Therapeutic': [488], 'efficacy': [489], 'tolerability': [491], 'influenced': [502], '[abstract].': [507], 'In:': [508], 'Proceedings': [509], 'American': [512], 'Association': [513], 'Cancer': [515, 529], 'Research': [516], 'Annual': [517], 'Meeting': [518], '2019;': [519], '2019': [520], 'Mar': [521], '29-Apr': [522], '3;': [523], 'Atlanta,': [524], 'GA.': [525], 'Philadelphia': [526], '(PA):': [527], 'AACR;': [528], 'Res': [530], '2019;79(13': [531], 'Suppl):Abstract': [532], 'nr': [533], '1493.': [534]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2956001001', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-12T17:35:06.668238', 'created_date': '2019-07-12'}