Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata

Name: Work Video:
Duration: 3 min 30 s
Rebekka Christmann; Carla Thomas; Nadine Jager; Anne S. Raber; Brigitta Loretz; Ulrich F. Schaefer; Thomas Tschernig; Thomas Vogt; Claus‐Michael Lehr
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'shows': [157], 'potential.': [158], 'key': [160], 'benefits': [161], 'biodegradable': [164], 'polymeric': [165], 'NP': [166, 463, 629, 641, 738, 862, 1252, 1640, 1652, 1697, 1726, 1757, 2271, 3129, 3158, 3188, 3348, 3408, 3427, 3536, 3727, 3835, 3912], 'into': [168, 196, 301, 381, 465, 489, 515, 589, 612, 643, 678, 740, 864, 887, 1472, 1555, 1644, 1680, 1801, 1844, 1881, 2274, 2366, 2489, 2615, 2720, 2888, 3600], 'HFs': [169, 633, 1256, 1269, 1714, 1823, 1882, 2643, 2935, 3110, 3441, 3961], 'include': [170], '(i)': [171], 'protection': [172, 266], 'encapsulated': [175], 'drug,': [176], '(ii)': [177], 'minimization': [178], 'drug': [180, 203, 255, 299, 324, 397, 453, 513, 1631, 1678, 2364, 2487], 'exposure': [181], 'skin': [184, 455, 657, 747, 795, 1073, 1164, 1194, 1341, 2088, 2420, 2456, 2523, 2656, 2896, 2933, 3146, 3163, 3192, 3270, 3284, 3387, 3487, 3516, 3568], 'surface,': [185], 'well': [187], 'interfollicular': [189, 226, 2320], 'permeation,': [190], '(iii)': [191], 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'Release.': [240, 688, 897, 1854, 2334, 2625, 2730, 3610], '2016;': [241, 2335], '223:': [242, 2336], '207-214Crossref': [243, 2337], '(41)': [246, 2340], 'Scholar),': [248, 315, 1070, 1694, 2503], '(iv)': [249], 'possibility': [251], 'building': [253], 'depot': [256, 328], 'upper': [259, 390], 'part': [260, 391], 'HF,': [263, 394, 2276, 2924, 3996, 4020], 'creating': [264], 'possible': [265, 783], 'NPs': [269, 385, 488, 607, 853, 1160, 1265, 1357, 1399, 1798, 1876, 2161, 2870, 2884, 2921, 3060, 3079, 3267, 3280, 3326, 3437], 'from': [270, 326, 1232, 3059, 3507], 'external': [271], 'influences': [272], 'as,': [274], 'textile': [275], 'contact,': [276], 'washing': [277], '(Lademann': [278, 492, 1657, 2467], '2007Lademann': [281, 495, 1660, 2346, 2470], 'Richter': [283, 497, 1454, 1512, 1662, 2348, 2472], 'Teichmann': [285, 499, 1664, 2350, 2474], 'Otberg': [287, 501, 1666, 2352, 2476], 'N.': [288, 502, 1511, 1667, 2353, 2477], 'Blume-Peytavi': [289, 503, 1516, 1668, 2354, 2478], 'U.': 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885, 1842, 2145, 2613, 2718, 3598], 'transport': [547], '116:': [555], '125-130Crossref': [556], '(37)': [559], 'Additionally,': [562], 'appropriate': [563, 1906], 'massage': [564, 1042, 2280], 'seems': [565], 'important': [568], 'context': [571], '(Li': [572], '2019Li': [575], 'B.S.': [576], 'Cary': [577], 'J.H.': [578], 'Maibach': [579], 'H.I.': [580], 'Should': [581], 'we': [582, 604, 627, 732, 768, 848, 1246, 1316, 1637, 1695, 1790], 'instruct': [583], 'patients': [584], 'rub': [586], 'topical': [587], 'agents': [588], 'skin?:': [590], 'evidence.J': [592], 'Dermatolog': [593], 'Treat.': [594], '2019;': [595], '30:': [596], '328-332Crossref': [597], '(4)': [600], 'Thus,': [603], 'questioned': [605], 'if': [606, 1128, 2821], 'are': [608, 699, 725, 2936, 3369, 3548], 'able': [609, 1792], 'penetrate': [611, 1800, 1880], 'AA-affected': [613, 632, 1645, 1713], 'HFs,': [614, 646], 'where': [615], 'there': [616, 698], 'present.': [620], 'To': [621, 1309, 3103], 'fill': [622], 'these': [623], 'critical': [624, 726], 'knowledge': [625], 'gaps,': [626], 'studied': [628], 'deposition': [630, 1253, 1580, 1597, 1698, 1727, 1758, 2868, 3108, 3987, 4009], 'previously': [636, 857, 1816, 2998], 'developed': [637, 858], 'quantification': [638, 735, 771, 859, 2754, 2814], 'method': [639, 736, 772, 860, 1231], 'forearm': [645, 720, 742, 1207, 1233, 1259, 1291, 1371, 1553, 1822, 3497, 3892], 'demonstrating': [647, 1226, 3302], 'excellent': [649], 'vivo–in': [651], 'vitro': [652], 'correlation': [653], 'pig': [655, 682, 891, 1848, 2619, 2724, 3604], 'ear': [656, 683, 892, 1849, 2620, 2725, 3605], '(Raber': [658, 867, 1824], '2014Raber': [661, 870, 1827, 2598, 2703, 3583], 'A.S.': [662, 871, 971, 1828, 2168, 2599, 2704, 2955, 3005, 3584], 'Mittal': [663, 872, 965, 1829, 2600, 2705, 3585], 'Schäfer': [665, 874, 1831, 2602, 2707, 3587], 'Bakowsky': [667, 876, 1833, 2604, 2709, 3589], 'Reichrath': [669, 878, 1835, 2606, 2711, 3591], 'al.Quantification': [674, 883, 1840, 2611, 2716, 3596], 'follicles': [680, 889, 1846, 2617, 2722, 3602], 'forearm.J': [686, 895, 1852, 2623, 2728, 3608], '179:': [690, 899, 1856, 2627, 2732, 3612], '25-32Crossref': [691, 900, 1857, 2628, 2733, 3613], '(68)': [694, 903, 1860, 2631, 2736, 3616], 'quantitative': [701], 'data': [702, 724, 1565, 3886], 'scalp': [705, 746, 777, 1235, 1255, 1275, 1379, 1569, 1574, 1611, 1647, 1803, 3113, 3440, 3500, 3640, 3898], 'skin.': [706, 1236], 'Because': [707], 'density': [709, 1241], 'type': [712], '(vellus': [713], 'vs.': [714, 1169, 1184, 1198, 1588, 1605, 1778, 1784], 'terminal)': [715], 'differ': [716, 1499], 'healthy': [719, 749, 1209, 1244, 1274, 1378, 1568, 1610, 1703, 1783, 3496, 3499, 3891, 3894], 'scalp,': [722, 1210, 1245, 1615, 1786, 3522, 3544, 3895], 'assess': [728, 1310], 'options.': [730], 'Therefore,': [731, 3291], 'transferred': [733, 752], 'volunteers,': [750], 'subsequent': [751, 1080], 'it': [753], 'patients.': [756], 'recruitment': [759], 'participants': [761, 3503], 'studies': [764, 789, 828, 3476], 'limited.': [766], 'Accordingly,': [767], 'assessed': [769], 'also': [773, 1883], 'hairy': [776], 'body': [779, 800, 1410, 1505, 1531, 1572, 1613, 1620], 'donors': [780, 801, 1621], 'alternative': [784], 'future': [786, 1629], 'vivo': [788, 1643, 3475], '(experiments': [790], 'were': [791, 802, 829, 1098, 1126, 1387, 1791, 1877, 2100, 2518, 2661, 2669, 2696, 2743, 2815, 2819, 2915, 2994, 3080, 3181, 3221, 3254, 3327, 3512], 'conducted': [792], 'attached': [796], 'corpus;': [799], 'fixated': [804], 'before': [805], 'experiment': [807], 'kept': [809], 'at': [810, 1928, 1931], '4': [811], '°C;': [812], 'maximal': [813], 'post': [814], 'mortem': [815], 'interval': [816], 'was': [817, 1017, 1114, 1286, 1403, 1558, 1739, 1766, 1972, 2066, 2090, 2123, 2231, 2264, 2288, 2383, 2422, 2443, 2537, 2555, 2578, 2587, 2763, 2850, 2892, 2899, 3057, 3115, 3134, 3154, 3173, 3194, 3272, 3420], '3': [818], 'days)': [819], '(for': [820], 'study': [821, 1415, 1549], 'group': [822], 'details': [823], 'see': [824, 1008], 'Figure': [825, 1122, 1149, 1220, 1305, 2911, 3218, 3257, 3300, 3344, 3373, 3406, 3423, 3480, 3621, 3627, 3877, 3994, 4017], '1a).': [826, 1150], 'Ärztekammer': [833], 'des': [834], 'Saarlandes': [835], 'ethical': [836, 2908, 3450, 3464], 'committee,': [837], 'including': [838], 'informed': [839], 'written': [840], 'consent': [841], 'participants.': [843, 3459], 'model': [846], 'NPs,': [847, 907], 'continued': [849], 'use': [851], 'used': [854, 1624, 2519], 'size': [908, 913, 1526], '150': [910], 'nm,': [911, 3084, 3684, 3694, 3740, 3751, 3802, 3848], 'narrow': [912], 'distribution': [914, 1528], 'negative': [916], 'zeta': [917, 2247, 3096], 'potential,': [918], 'consisted': [919], 'fluorescently': [921, 1027, 2756, 2926, 3467], 'covalently': [922, 1028, 2155, 2757, 2927, 3468], 'labeled': [923, 1029, 2156, 2758, 2928, 3469], 'poly': [924, 2157], '(lactic-co-glycolic': [925, 2158], 'acid)': [926, 2159], '(PLGA),': [927], 'biodegradable,': [929], 'biocompatible': [930], 'polymer': [931, 3052], '(Wang': [932], '2018Wang': [935, 2201], 'E.H.C.': [936, 2202], 'Sallee': [937, 2203], 'B.N.': [938, 2204], 'Tejeda': [939, 2205], 'C.I.': [940, 2206], 'JAK': [943, 2209], 'inhibitors': [944, 2210], 'areata.J': [949, 2215], 'Invest': [950, 1476, 1533, 2216], '2018;': [952, 2218], '138:': [953, 2219], '1911-1916Abstract': [954, 2220], 'Full': [955, 957, 1481, 1483, 1538, 1540, 2221, 2223], 'Text': [956, 958, 1482, 1484, 1539, 1541, 2222, 2224], 'PDF': [959, 1485, 1542, 2225], '(26)': [962, 2228], '2013Mittal': [968, 2165, 2952, 3002], 'Raber': [970, 2167, 2595, 2700, 2954, 3004, 3580], 'Schaefer': [972, 1514, 2169, 2778, 2956, 3006], 'U.F.': [973, 2170, 2779, 2957, 3007], 'Weissmann': [974, 2171, 2958, 3008], 'Ebensen': [976, 2173, 2960, 3010], 'Schulze': [978, 2175, 2962, 3012], 'K.': [979, 2176, 2963, 3013], 'al.Non-invasive': [981, 2178, 2965, 3015], 'follicles:': [987, 2184, 2971, 3021], 'perspective': [989, 2186, 2973, 3023], 'transcutaneous': [991, 2188, 2975, 3025], 'immunization.Vaccine.': [992, 2189, 2976, 3026], '2013;': [993, 2190, 2977, 3027], '31:': [994, 2191, 2978, 3028], '3442-3451Crossref': [995, 2192, 2979, 3029], '(51)': [998, 2195, 3032], 'detailed': [1003], 'description': [1004], 'procedure,': [1007], 'Supplementary': [1009, 1219, 3299, 3343, 3372], 'Materials': [1010], 'Methods.': [1012], 'In': [1013, 1788, 3411, 3460], 'brief,': [1014], 'differential': [1015, 1112, 3491, 3561], 'stripping': [1016, 1078, 1113, 2382, 3562, 3885], 'proceeded': [1018, 2384], '1': [1019, 2069, 3118, 3766], 'hour': [1020], 'after': [1021, 1111, 1202, 1745, 2385, 3560], 'applying': [1022], '15': [1023, 2140, 2259, 3714], 'μl': [1024, 2141, 2260, 3126], 'aqueous': [1026, 2144], 'PLGA-NP': [1030, 2759, 3107, 3305], 'suspension': [1031, 2147, 2760], '(concentration': [1032, 2148], '=': [1033, 2149, 3703, 3707, 3711, 3718, 3759, 3763, 3770, 3811, 3815, 3819, 3826, 3857, 3861, 3865, 3872], '50': [1034, 2150], 'mg/ml)': [1035, 2151], 'per': [1036, 1270, 1284, 1300, 1359, 1401, 1581, 1598, 1728, 1753, 1759, 2233, 2257, 2871, 3120, 3913, 3962, 3975], 'area': [1038, 1272, 1320, 1347, 1361, 1583, 1730, 2122, 2442, 2561, 2647, 2861, 2873, 3122, 3964], '3-minute': [1041, 2278], '(Scientific': [1043, 2390], 'Committee': [1044, 1049, 1143, 2391, 2396, 2837], 'on': [1045, 1050, 1144, 1162, 1178, 1192, 1242, 1339, 1368, 2392, 2397, 2644, 2838, 2847, 3161, 3268, 3282, 3385, 3495, 3501, 3514, 3527, 3535, 3638], 'Consumer': [1046, 1051, 1145, 2393, 2398, 2839], 'Safety,': [1047, 2394], '2018Scientific': [1048, 2395], 'SafetyThe': [1052, 2399], 'SCCS': [1053, 2400], 'Notes': [1054, 2401], 'Guidance': [1056, 2403], 'Testing': [1059, 2406], 'Cosmetic': [1061, 2408], 'Ingredients': [1062, 2409], 'their': [1064, 1913, 2411], 'Safety': [1065, 1146, 2412, 2840], 'Evaluation': [1066, 2413], '10th': [1067, 2414], 'Revision.https://ec.europa.eu/health/sites/health/files/scientific_committees/consumer_safety/docs/sccs_o_224.pdfDate:': [1068, 2415], '2018Google': [1069, 2416], 'comprises': [1072], 'surface': [1074, 1165, 1342, 2089, 2421, 2457, 2524, 2560, 2657, 3164, 3271, 3285, 3388, 3569], 'cleaning': [1075, 3147], 'tape': [1077, 2425, 2438, 2447, 2516, 2566, 2576, 2674, 3149], 'removal': [1081, 2429, 2526, 2532, 2640, 3153], 'casts': [1084, 2432, 2536], 'cyanoacrylate': [1086, 1203, 2434, 2544, 2572, 2683], 'biopsies.': [1087, 2435, 2545], 'mass': [1089, 1135, 2652, 2832], 'balance,': [1090, 2653], 'all': [1091], 'samples': [1092, 2668], 'contact': [1094], 'formulation': [1097, 3130, 3159], 'extracted': [1099], 'organic': [1101, 3051], 'solvent': [1102], 'analyzed': [1104, 2670], 'using': [1105, 1321, 1349, 2116, 2125, 2540], 'fluorescence': [1106, 2694, 2740, 2945, 2988, 3359, 3419], 'intensity.': [1107], 'Stratum': [1108], 'corneum': [1109, 2529, 3558], 'recovery': [1110], 'monitored': [1115, 2900], 'transepidermal': [1117, 2902], 'water': [1118, 2263, 3065, 3482], 'loss': [1119, 3483], 'measurements': [1120, 2904, 3485, 3494, 3511, 3526, 3534], '(Supplementary': [1121, 1216, 2910, 3217, 3256, 3405, 3422], 'S1).': [1123, 2912], 'Experimental': [1124, 2817], 'sets': [1125, 2818], 'excluded': [1127, 2820], 'they': [1129, 2822], 'did': [1130, 2823], 'meet': [1132, 2825], '85–115%': [1134, 2826], 'limits': [1137], 'recommended': [1139, 2829], 'Scientific': [1142, 2836], 'guidelines': [1147, 2841], '(2018;': [1148], 'Comparing': [1151], 'percentage': [1152, 1174, 1190], 'dose': [1154, 1176, 3909], '(mean': [1155], '±': [1156, 1167, 1171, 1182, 1186, 1196, 1200, 1277, 1281, 1293, 1297, 1373, 1381, 1585, 1590, 1602, 1607, 1705, 1709, 1716, 1720, 1775, 1780, 2239, 2245, 2250, 3082, 3092, 3100, 3552, 3888, 3919, 3921, 3923, 3925, 3928, 3930, 3932, 3934, 3936, 3938, 3940, 3942, 3944, 3946, 3948, 3951, 3953, 3955, 3957, 3966, 3968, 3970, 3972, 3978, 3980, 3982, 3984], 'SD)': [1157, 3889], 'recovered': [1161], '(61.0': [1166], '4.1%': [1168], '56.4': [1170], '3.7%),': [1172, 1187], 'remaining': [1177, 3281], 'glove': [1180, 2672], '(28.1': [1181], '5.5%': [1183], '24.1': [1185], 'left': [1191], '(0.1': [1195], '0.2%': [1197], '1.3': [1199], '1.1%)': [1201], 'biopsies,': [1204, 2684], 'respectively,': [1211], 'showed': [1212], 'significant': [1214, 1391, 1560, 1740], 'differences': [1215, 1386, 1444], 'Table': [1217, 3883], 'S1;': [1218], 'S2,': [1221], 'red': [1222, 3358, 3418], 'purple': [1224], 'bars),': [1225], 'successful': [1227], 'transfer': [1228], 'Owing': [1237], 'higher': [1239, 1249, 1288], 'amount': [1250, 1263, 1397, 1466, 1577, 2882, 3265], 'than': [1257, 1289, 2809], 'HFs.': [1260, 1648, 1804, 1919, 3168, 4011], 'Indeed,': [1261], 'deposited': [1266, 1358, 1400, 2887, 3287, 3959, 3974], '(8.5': [1276, 1704], '3.6%': [1278, 1706], 'equals': [1279, 1295, 1707, 1718], '59.79': [1280, 1708], '24.46': [1282, 1586, 1710], 'μg/HFs': [1283, 1299], 'area)': [1285, 1301], 'significantly': [1287, 1498, 1769], '(2.5': [1292], '0.9%': [1294], '19.05': [1296], '12.78': [1298], '(P': [1302, 1741, 1771], '≤': [1303, 1742], '0.001;': [1304], '2a,': [1306], 'gray': [1307, 1733], 'bars).': [1308], 'influence': [1312], 'density,': [1315], 'documented': [1317, 2124], 'each': [1318, 1344, 2097, 2859], 'dermatoscope': [1323, 2127], '(handyscope,': [1324, 2128], 'FotoFinder,': [1325, 2129], 'Bad': [1326, 2130], 'Birnbach,': [1327, 2131], 'Germany)': [1328, 2085, 2115, 2132, 2554, 3216, 3235, 3402], '(Figure': [1329, 1392, 1593, 1731, 1762], '1b)': [1330], 'determined': [1332], 'number': [1334, 1420, 1749, 2876], 'orifices': [1337, 1752, 2846, 2879], 'visible': [1338], 'individual': [1345, 2267, 2747], 'manually': [1348, 2852], 'ImageJ': [1350, 2854], '(ImageJ': [1351, 2855], '1.51j8,': [1352, 2856], 'NIH).': [1353], 'After': [1354, 2568, 3138], 'normalizing': [1355], 'different': [1364, 1501, 1530, 1770], 'orifice': [1366], 'densities': [1367, 1494], '(0.75': [1372], '0.57': [1374], 'μg/one': [1375, 1383], 'HF)': [1376], '(0.42': [1380, 1601], '0.16': [1382, 1603, 1776], 'HF),': [1384], 'longer': [1389, 1768], 'statistically': [1390], '2b),': [1393], 'that': [1394, 1413, 1619, 1795, 2634], 'about': [1404], 'same,': [1406], 'regardless': [1407], 'site.': [1411], 'Given': [1412], 'limited': [1417], 'its': [1419, 2659], 'participants,': [1422], 'need': [1425], 'considered': [1428], 'carefully.': [1429], 'Nevertheless,': [1430], 'interesting': [1434], 'result,': [1435], 'because': [1436, 2925, 2940, 3449, 3462], 'fundamental': [1442], 'morphometric': [1443], '(Teichmann': [1445], '2005Teichmann': [1448], 'Jacobi': [1450], 'Ossadnik': [1452], 'Koch': [1456], 'al.Differential': [1461], 'stripping:': [1462], 'determination': [1463], 'substances': [1470], 'penetrated': [1471], 'follicles.J': [1475], '2005;': [1478], '125:': [1479], '264-269Abstract': [1480], '(127)': [1488], 'Also,': [1491], 'infundibular': [1496], 'surfaces': [1497], 'covered': [1504, 2444, 2563], 'sites': [1506], '(Otberg': [1507], '2004Otberg': [1510], 'Variations': [1522], 'sites.J': [1532], '2004;': [1535], '122:': [1536], '14-19Abstract': [1537], '(303)': [1545], 'This': [1548, 1617, 1805, 1891, 1970, 2586], 'takes': [1550], 'only': [1551, 3384, 3443, 3466], 'account.': [1556], 'difference': [1561, 1724], 'when': [1562], 'comparing': [1563], 'donation': [1573, 2008], 'regarding': [1575], '(59.79': [1584], 'μg': [1587, 1604, 1777], '41.83': [1589], '18.53': [1591], 'μg)': [1592, 1711, 2886], '2b)': [1594], 'or': [1595, 3151], 'single': [1599, 1760, 2890], '0.33': [1606], '0.21': [1608], 'μg,': [1609, 1782], 'donor': [1614], 'respectively).': [1616, 1787], 'implies': [1618], 'may': [1622], 'models': [1626], 'develop': [1628], 'follicle-targeted': [1630], 'carriers': [1632], 'dermatological': [1634], 'Finally,': [1636], 'investigated': [1638], 'hairless': [1646], 'Despite': [1649], 'postulated': [1651], 'demonstrated': [1696], '(2.7': [1715], '0.4%': [1717], '20.49': [1719], '2.90': [1721], 'μg);': [1722], '2b,': [1732, 1763], 'bars)': [1734, 1765], 'two': [1737, 2543, 2636, 2678, 2681], 'groups': [1738], '0.01).': [1743], 'Interestingly,': [1744], 'correction': [1746, 2864], 'area,': [1755], 'white': [1764, 3519, 3541], '>': [1772], '0.05;': [1773], '0.42': [1774], '0.23': [1779], '0.07': [1781, 3091], 'conclusion,': [1789], 'demonstrate': [1794], 'do': [1799, 3452], 'phenomenon': [1806], 'appeared': [1807], 'same': [1812, 3184], 'scale': [1813], 'reported': [1817, 3578], 'Scholar)': [1862, 2230, 2984, 3034], 'independent': [1867], 'type.': [1871], 'Moreover,': [1872], 'and,': [1873], 'most': [1874, 1901], 'importantly,': [1875], 'found': [1878, 1927], 'absence': [1886], 'shaft.': [1890], 'opens': [1892], 'possibilities': [1893], 'inflammatory': [1898], 'loss,': [1900], 'importantly': [1902], 'AA,': [1903], 'designing': [1905], 'nanomedicines': [1907], 'capable': [1908], 'penetrating': [1910], 'delivering': [1912], 'cargo': [1914], 'directly': [1915], 'affected': [1918], 'Datasets': [1920], 'related': [1921], 'article': [1924], 'can': [1925, 2648, 3381, 3442], 'https://doi.org/10.17632/fn6gg3f4py.1,': [1929], 'hosted': [1930], 'Mendeley': [1932], 'Data.': [1933], 'Rebekka': [1934], 'Christmann:': [1935], 'http://orcid.org/0000-0003-1775-2113': [1936], 'Carla': [1937], 'Thomas:': [1938], 'http://orcid.org/0000-0002-9809-9533': [1939], 'Nadine': [1940], 'Jager:': [1941], 'http://orcid.org/0000-0002-5216-8441': [1942], 'Anne': [1943], 'Raber:': [1945], 'http://orcid.org/0000-0003-0018-2652': [1946], 'Brigitta': [1947], 'Loretz:': [1948], 'http://orcid.org/0000-0003-0057-5181': [1949], 'Ulrich': [1950], 'Schaefer:': [1952], 'http://orcid.org/0000-0002-2470-2168': [1953], 'Thomas': [1954, 1957], 'Tschernig:': [1955], 'http://orcid.org/0000-0002-7788-1796': [1956], 'Vogt:': [1958], 'http://orcid.org/0000-0002-2824-5005': [1959], 'Claus-Michael': [1960], 'Lehr:': [1961], 'http://orcid.org/0000-0002-5864-8462': [1962], 'authors': [1964], 'declare': [1965], 'conflict': [1967], 'interest.': [1969], 'work': [1971], 'supported': [1973], 'Dr.': [1975], 'Rolf': [1976], 'Schwiete': [1978], 'Stiftung': [1979], ',': [1980, 1982], 'Mannheim': [1981], 'Germany': [1983, 2004], '(Project-Nr.': [1984], '14/2016).': [1985], 'We': [1986], 'thank': [1987], 'Olga': [1988], 'Hartwig': [1989], 'help': [1991], 'confocal': [1993, 3225], 'laser': [1994, 3226, 3629], 'scanning': [1995, 3227, 3630], 'microscope,': [1996], 'UHU,': [1997], 'Bühl/Baden,': [1998, 2553], 'Germany,': [1999], 'tesa': [2001], 'SE,': [2002], 'Norderstedt,': [2003, 2451], 'kind': [2007], 'materials.': [2010], 'Conceptualization:': [2011], 'TV,': [2012, 2017, 2035, 2062], 'UFS,': [2013, 2025, 2039, 2048, 2060], 'CML;': [2014, 2018], 'Funding': [2015], 'Acquisition:': [2016], 'Investigation:': [2019], 'RC,': [2020, 2026, 2047, 2055], 'CT,': [2021, 2034, 2056], 'NJ;': [2022], 'Methodology:': [2023], 'ASR,': [2024, 2058], 'CT;': [2027], 'Project': [2028], 'Administration:': [2029], 'BL,': [2030, 2038, 2059], 'TV;': [2031, 2041], 'Resources:': [2032], 'TT,': [2033, 2061], 'RC;': [2036], 'Supervision:': [2037], 'CML,': [2040], 'Writing': [2042, 2050], '-': [2043, 2051], 'Original': [2044], 'Draft': [2045], 'Preparation:': [2046], 'BL;': [2049], 'Review': [2052], 'Editing:': [2054], 'NJ,': [2057], 'CML.': [2063], 'Initially,': [2064], 'cut': [2067, 3211, 3255], 'mm': [2070], 'electrical': [2073], 'shaver': [2074], '(Braun': [2075], 'Bartschneider,': [2076], 'BT3040,': [2077], 'Procter': [2078], 'Gamble': [2080], 'Service,': [2081], 'Schwalbach': [2082], 'am': [2083], 'Taunus,': [2084], 'cleansed': [2091], 'hair.': [2094], 'Application': [2095, 3240], 'areas,': [2096], '1,767': [2098, 3914], 'cm2,': [2099], 'marked': [2101], 'permanent': [2104, 2109, 3567], 'black': [2105, 3523], 'marker': [2106], '(Faber-Castell': [2107], 'MULTIMARK': [2108], '152399,': [2110], 'A.W.': [2111], 'Faber-Castell': [2112], 'Vertrieb,': [2113], 'Stein,': [2114], 'Teflon': [2118], 'mask.': [2119], 'Each': [2120], 'counting': [2134], 'orifices.': [2138], 'Then,': [2139], '(NP)': [2146], 'composed': [2152], 'fluoresceinamine': [2154], '(PLGA)': [2160], '(Mittal': [2162, 2949, 2999], 'Wang': [2198], 'area.': [2235], 'Particle': [2236], 'size,': [2237], '149.04': [2238], '3.46': [2240], 'nm;': [2241], 'polydispersity': [2242, 3088], 'index,': [2243], '0.06': [2244], '0.02;': [2246], 'potential': [2248, 3097], '−24.64': [2249], '6.85': [2251], 'mV.': [2252, 3102], 'On': [2253, 3260, 3320], 'blank': [2254, 2748, 3338, 3413], 'areas': [2255, 3177, 3530, 3538], '(one': [2256, 2676], 'participant),': [2258], 'purified': [2262, 3064], 'vehicle': [2268], 'control.': [2269], 'enhancement': [2273], 'circular': [2279], 'slight': [2282, 3556], 'pressure': [2283], '(60': [2284], 'r.p.m.,': [2285], '∼2': [2286], 'Newton)': [2287], 'trained': [2292], 'person': [2293], 'gloved': [2296], 'fingertip': [2297], 'Differential': [2381], '1-hour': [2387], 'incubation': [2388, 3140], 'time': [2389], 'First,': [2418], 'cleaned': [2423, 2559, 2662], 'stripping,': [2426, 2439], 'followed': [2427], 'one': [2446, 2507, 2584, 2889, 3508], 'strip': [2448, 2577], '(tesafilm': [2449], 'kristall-klar,': [2450], 'Germany),': [2452], 'pressed': [2453], 'onto': [2454], 'paint': [2460], 'roller': [2461], '(to': [2462], 'reach': [2463], 'furrows': [2464], 'crinkles)': [2466], 'al.Nanoparticles--an': [2483], '(430)': [2501], 'removed': [2505, 2579], 'swoop': [2508], 'forceps.': [2510], 'A': [2511], 'total': [2512], '12': [2514], 'successive': [2515], 'strips': [2517, 2675], 'clean': [2521], 'stratum': [2528, 3557], 'layers.': [2530], 'carried': [2538], 'out': [2539], 'following': [2542], 'One': [2546], 'superglue': [2549], '(UHU': [2550], 'blitzschnell': [2551], 'Pipette,': [2552], 'strip.': [2567], 'polymerization': [2569], '(5': [2573], 'minutes),': [2574], 'forceps': [2582], 'swoop.': [2585], 'done': [2588, 2697, 2851], 'twice.': [2589], 'It': [2590], 'has': [2591], 'been': [2592, 3577], 'shown': [2593, 3297, 3341, 3370, 3445], 'biopsies': [2637], 'complete': [2639], 'achieved.': [2650], 'treated': [2655, 3182, 3533, 3543], 'surroundings': [2660], 'cotton': [2665, 2686], 'ball.': [2666], 'All': [2667], 'separately:': [2671], 'fingertip,': [2673], 'separately,': [2679], 'then': [2680], 'together),': [2682], 'ball': [2687], '(skin': [2688], 'rest).': [2689], 'Extraction': [2690], 'analyzation': [2692], 'spectroscopy': [2695], 'according': [2698, 2765, 2905], 'Scholar.': [2738], 'Relative': [2739], 'unit': [2741], 'values': [2742], 'corrected': [2744], 'matrix': [2749], 'value.': [2750], 'Lower': [2751], 'limit': [2752, 2812], 'calibration': [2761], 'curve': [2762], 'calculated': [2764], 'FDA': [2768], 'Bioanalytical': [2769], 'Method': [2770], 'Validation': [2771], 'guideline': [2772], '(Weiss': [2773], '2006Weiss': [2776], 'Zapp': [2780], 'Lamprecht': [2782], 'Stallmach': [2784], 'Lehr': [2786], 'C.M.': [2787], 'Nanoparticles': [2788], 'made': [2789], 'fluorescence-labelled': [2791], 'Poly(L-lactide-co-glycolide):': [2792], 'preparation,': [2793], 'stability,': [2794], 'biocompatibility.J': [2796], 'Nanosci': [2797], 'Nanotechnol.': [2798], '2006;': [2799], '6:': [2800], '3048-3056Crossref': [2801], 'Values': [2807], 'lower': [2808, 2811], 'excluded.': [2816], 'range': [2830], '(2018).': [2842], 'Count': [2843], 'dermatoscopic': [2848], 'pictures': [2849], 'NIH)': [2857], 'individually.': [2862], 'By': [2863], 'counted,': [2880], '(in': [2885], 'determined.': [2893], 'Recovery': [2894], 'barrier': [2897], 'function': [2898], 'water-loss': [2903], 'committee': [2909], 'DiD-loaded': [2913, 2992, 3106, 3304, 3377, 3635, 3669, 3787], 'PLGA-NPs': [2914, 2993, 3378, 3636, 3670, 3788], 'chosen': [2916], 'visualization': [2919], 'inside': [2922, 3109, 3308, 3390, 3438], '-PLGA-NPs': [2929], 'conjugation': [2931], 'difficult': [2937], 'differentiate,': [2939], 'high': [2943, 3274], 'auto': [2944], 'organs': [2948], '(63)': [2982], 'terminated': [2987], 'intensity': [2989], 'Fluorescein.': [2991], 'prepared': [2995], 'described': [2997], 'addition': [3036], 'Vybrant': [3038], 'DiD': [3039, 3677, 3733, 3795, 3841], 'cell-labeling': [3040], 'solution': [3041], '(Vybrant': [3042], 'Multicolor': [3043], 'Cell-Labeling': [3044], 'Kit,': [3045], 'Invitrogen,': [3046], 'Waltham,': [3047], 'MA)': [3048], 'solution.': [3053], 'dye': [3056], 'separated': [3058], 'dialysis': [3062], '(Spectra/Por': [3066], 'Float-a-Lyzer,': [3067], '100': [3068, 3252, 3719, 3827, 3873], 'kDa,': [3069], 'Spectrum': [3070], 'Europe': [3071, 3202], 'B.V.,': [3072, 3203], 'Breda,': [3073], 'Netherlands)': [3075, 3209], '29': [3077], 'hours.': [3078], '124.0': [3081], '0.9': [3083], 'had': [3086], 'index': [3089], '0.02': [3093], '−21.8': [3099], '0.2': [3101], 'visualize': [3104], '(before': [3111], 'shortened': [3116], 'mm)': [3119], '(1,767': [3123], 'cm2),': [3124], '20': [3125, 3367], '(250': [3131], 'mg': [3132], 'PLGA/ml)': [3133], 'massage.': [3137], 'time,': [3141], 'further': [3143], 'procedure': [3144], '(no': [3148], 'stripping)': [3150], 'applied;': [3155], 'remained': [3160], 'An': [3169], '8-mm': [3170], 'punch': [3171], 'biopsy': [3172, 3339], 'taken.': [3174], 'Blank': [3175, 3525, 3528], '(Control': [3178], 'without': [3179, 3185, 3347, 3426, 3566, 3726, 3834], 'NP)': [3180], 'formulation.': [3189], 'Subsequently,': [3190], 'tissue': [3193, 3364, 3414], 'imbedded': [3195], 'Tissue-Tek': [3197], 'O.C.T.': [3198], 'Compound': [3199], '(Sakura': [3200], 'Finetek': [3201], 'Alphen': [3204], 'aan': [3205], 'den': [3206], 'Rijn,': [3207], 'cryostat': [3213], '(SLEE,': [3214], 'Mainz,': [3215], 'S3).': [3219], 'Images': [3220], 'microscope': [3228, 3631], '(CLSM)': [3229, 3632], '(Leica': [3230], 'TCS': [3231], 'SP8,': [3232], 'Leica,': [3233], 'Mannheim,': [3234, 3247], 'processed': [3237], 'Leica': [3239], 'Suite': [3241], 'X': [3242], '(LAS': [3243], 'X)': [3244], 'software': [3245], '(Leica,': [3246], 'Germany).': [3248], 'Transversal': [3249], 'sections': [3250, 3365], 'μm': [3253, 3368], 'S3c,': [3258, 3301], 'S3d).': [3259], 'first': [3262], 'section,': [3263, 3324], 'too': [3273], 'sufficient': [3277], 'differentiation': [3278], 'HF.': [3290], 'second': [3293, 3332], '100-μm': [3294, 3323, 3334, 3775], 'section': [3295, 3335], '(red': [3306, 3379], 'fluorescence)': [3307, 3380, 3404], 'shaft': [3312, 3394], 'present)': [3314], '(overlay': [3315], 'transmission': [3317, 3354, 3656, 3662, 3780], 'light': [3318, 3355, 3657, 3663, 3781], 'image).': [3319], 'third': [3322], 'detectable': [3328, 3421], '(not': [3329], 'shown).': [3330], 'transversal': [3333, 3776], 'S3d': [3345], '(control': [3346, 3517], '[HF': [3349, 3428], 'shaft]': [3352], '[overlay': [3353], 'image': [3356, 3624, 3667, 3723, 3785, 3831, 3880], 'channel).': [3360], 'Results': [3361, 3547, 3554], 'longitudinal': [3363, 3648], 'S3a': [3374], 'b.': [3376], 'detected': [3383], 'present),': [3396], 'counterstaining': [3397], 'DAPI': [3399, 3687, 3743], '(Sigma,': [3400], 'Darmstadt,': [3401], '(blue': [3403, 3432], 'S3a,': [3407], 'HF).': [3410], 'sections,': [3415, 3649, 3777], 'strong': [3417], 'S3b,': [3424], 'control': [3425, 3489, 3521], 'shaft])': [3431], 'fluorescence:': [3433], 'DAPI).': [3434], 'Visualization': [3435], 'Body': [3447, 3643, 3896], 'Donors,': [3448], 'reasons': [3451], 'allow': [3454], 'invasive': [3455], 'procedures': [3456], 'living': [3458], 'addition,': [3461], 'reasons,': [3465], '-PLGA-NP': [3470], 'used.Supplementary': [3479], 'S1Transepidermal': [3481], '(TEWL)': [3484], 'damage': [3488, 3559, 3570], 'through': [3490], 'stripping.': [3492], 'Exemplary': [3493], 'four': [3502], '(after': [3504], '9': [3505], 'days': [3506], 'participant).': [3509], 'untreated': [3515], 'forearm,': [3518, 3540], 'triangle;': [3520], 'triangle),': [3524], '(star)': [3531], '(treated': [3539], 'square;': [3542], 'block': [3545], 'square).': [3546], 'presented': [3549], 'mean': [3551], 'SD.': [3553], 'fast': [3564], 'recovery,': [3565], 'method.': [3573], 'Similar': [3574], 'have': [3576], 'Scholar.View': [3618], 'Large': [3619, 3875], 'Image': [3620, 3876], 'ViewerDownload': [3622, 3878], 'Hi-res': [3623, 3879], 'Download': [3625, 3881], '(PPT)Supplementary': [3626, 3882], 'S3Confocal': [3628], 'images': [3633], 'Donor.': [3644], '(a,': [3645], 'b)': [3646], '20-μm': [3647], 'counterstained': [3650], 'DAPI;': [3652], 'left-hand': [3653], 'images,': [3654, 3660], 'overlay;': [3658], 'right-hand': [3659], 'overlay.': [3664], '(a)': [3665], 'CLSM': [3666, 3722, 3784, 3830], '(red)': [3671, 3789], '(with': [3674, 3730, 3792, 3838], 'shaft);': [3676, 3732, 3794, 3840], 'detection:': [3678, 3688, 3734, 3744, 3796, 3842], 'HeNe': [3679, 3735, 3797, 3843], '633': [3680, 3736, 3798, 3844], 'laser,': [3681, 3691, 3737, 3747, 3799, 3845], 'emission:': [3682, 3692, 3738, 3748, 3800, 3846], '665–680': [3683, 3739, 3801, 3847], 'gain': [3685, 3695, 3741, 3752, 3803, 3849], '40;': [3686, 3804, 3850], 'diode': [3689, 3745], '405': [3690, 3746], '430–450': [3693], '60;': [3696, 3753], 'magnification': [3697, 3754, 3805, 3851], '×25;': [3698, 3806, 3852], 'pixel': [3699, 3756, 3807, 3853], 'size/voxel': [3700, 3808, 3854], 'size:': [3701, 3757, 3809, 3855], 'x': [3702, 3758, 3810, 3856], '0.455': [3704, 3708, 3858, 3862], 'μm,': [3705, 3709, 3813, 3817, 3859, 3863], 'y': [3706, 3762, 3814, 3860], 'z': [3710, 3818, 3864], '2.664': [3712], 'μm;': [3713, 3821, 3867], 'frames.': [3715, 3823, 3869], 'Scale': [3716, 3768, 3824, 3870], 'bars': [3717, 3769], 'μm.': [3720, 3772, 3828], '(b)': [3721], '100;': [3742], '430–': [3749], '450': [3750], '×10;': [3755], '0.001': [3760, 3764], 'mm,': [3761], 'mm;': [3765], 'frame.': [3767], '200': [3771], '(c,': [3773], 'd)': [3774], 'overlay': [3778], 'channel.': [3782], '(c)': [3783], '0.104': [3812, 3816], '−0.568': [3820], '137': [3822], 'bar': [3825, 3871], '(d)': [3829], '3.582': [3866], '25': [3868], 'μm.View': [3874], 'S1Differential': [3884], '(Mean': [3887], 'Donor': [3897], 'areata-affected': [3901], 'scalpNo.': [3902], 'experimental': [3904], 'setsForearmScalpHealthyHealthyBody': [3905], 'DonorAlopecia': [3906], 'Areata13765%': [3907], 'cm2': [3915], 'areaSkin': [3917], 'surface61.0': [3918], '4.156.4': [3920], '3.765.2': [3922], '5.560.9': [3924], '5.4Skin': [3926], 'rest0.1±0.21.3': [3927], '1.10.9': [3929], '0.70.2': [3931], '0.20Glove28.1': [3933], '5.524.1': [3935], '3.729.3': [3937], '10.238.7': [3939], '6.7HF2.5': [3941], '0.98.5': [3943], '3.65.4': [3945], '3.12.7': [3947], '0.4Mass': [3949], 'balance91.7': [3950], '3.290.3': [3952], '3.4100.9': [3954], '3.4102.6': [3956], '3.1NP': [3958], '(μg)HF19.05': [3965], '12.7859.79': [3967], '24.4641.83': [3969], '18.5320.49': [3971], '2.90NP': [3973], '(μg)HF0.75': [3977], '0.570.42': [3979], '0.160.33': [3981], '0.210.23': [3983], '0.07Boldface': [3985], 'indicates': [3986, 4008], 'HFs.For': [3989], 'statistical': [3990, 4013], 'analysis,': [3991, 4014], 'refer': [3992, 4015], '2b.Abbreviations:': [3995], 'follicle;': [3998, 4022], 'NP,': [3999, 4023], 'nanoparticle.': [4000, 4024], 'Open': [4001], 'table': [4002], 'new': [4005], 'tab': [4006], 'Boldface': [4007], '2b.': [4018], 'Abbreviations:': [4019]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2955984083', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2025-01-08T02:49:44.972197', 'created_date': '2019-07-12'}
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