Abstract CT031: Preliminary efficacy and safety results of savolitinib treating patients with pulmonary sarcomatoid carcinoma (PSC) and other types of non-small cell lung cancer (NSCLC) harboring <i>MET</i> exon 14 skipping mutations

Name: Work Video:
Duration: 3 min 30 s
Shun Lü; Jian Fang; Lejie Cao; Xingya Li; Qisen Guo; Jianying Zhou; Ying Cheng; Liyan Jiang; Yuan Chen; Helong Zhang; Zongan Liang; Xin Zhang; Wu B; Jianhua Shi; Hua Xu; Jianjin Huang; Zhixiong Yang; Shan Zeng; Yanping Hu; Xiaodong Zhang; Jingxun Wu; Gongyan Chen; Nong Yang; Longzhen Zhang; Yinjia Fu; Jing Li; Linfang Wang; Yongxin Ren; Weiguo Su
{'id': 'https://openalex.org/W2954952522', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-ct031', 'title': 'Abstract CT031: Preliminary efficacy and safety results of savolitinib treating patients with pulmonary sarcomatoid carcinoma (PSC) and other types of non-small cell lung cancer (NSCLC) harboring <i>MET</i> exon 14 skipping mutations', 'display_name': 'Abstract CT031: Preliminary efficacy and safety results of savolitinib treating patients with pulmonary sarcomatoid carcinoma (PSC) and other types of non-small cell lung cancer (NSCLC) harboring <i>MET</i> exon 14 skipping mutations', 'publication_year': 2019, 'publication_date': '2019-07-01', 'ids': {'openalex': 'https://openalex.org/W2954952522', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-ct031', 'mag': '2954952522'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-ct031', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004928583', 'display_name': 'Shun Lü', 'orcid': 'https://orcid.org/0000-0001-8833-7262'}, 'institutions': [{'id': 'https://openalex.org/I2802608112', 'display_name': 'Shanghai Chest Hospital', 'ror': 'https://ror.org/03fjc3817', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802608112']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shun Lu', 'raw_affiliation_strings': ['1Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China;'], 'affiliations': [{'raw_affiliation_string': '1Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China;', 'institution_ids': ['https://openalex.org/I2802608112', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089852487', 'display_name': 'Jian Fang', 'orcid': 'https://orcid.org/0000-0003-3697-4563'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4210093964', 'display_name': 'Peking University Cancer Hospital', 'ror': 'https://ror.org/00nyxxr91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093964']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian Fang', 'raw_affiliation_strings': ['2Beijing Cancer Hospital, Peking University, Beijing, China;'], 'affiliations': [{'raw_affiliation_string': '2Beijing Cancer Hospital, Peking University, Beijing, China;', 'institution_ids': ['https://openalex.org/I20231570', 'https://openalex.org/I4210093964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108293251', 'display_name': 'Lejie Cao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I126520041', 'display_name': 'University of Science and Technology of China', 'ror': 'https://ror.org/04c4dkn09', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I126520041', 'https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lejie Cao', 'raw_affiliation_strings': ['3The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Tecnology of China, Hefei, China;'], 'affiliations': [{'raw_affiliation_string': '3The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Tecnology of China, Hefei, China;', 'institution_ids': ['https://openalex.org/I126520041']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102845102', 'display_name': 'Xingya Li', 'orcid': 'https://orcid.org/0000-0002-8265-7318'}, 'institutions': [{'id': 'https://openalex.org/I4210156804', 'display_name': 'First Affiliated Hospital of Zhengzhou University', 'ror': 'https://ror.org/056swr059', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210156804']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xingya Li', 'raw_affiliation_strings': ['4The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;'], 'affiliations': [{'raw_affiliation_string': '4The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;', 'institution_ids': ['https://openalex.org/I4210156804']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085409628', 'display_name': 'Qisen Guo', 'orcid': 'https://orcid.org/0000-0003-4304-6431'}, 'institutions': [{'id': 'https://openalex.org/I4210163399', 'display_name': 'Shandong First Medical University', 'ror': 'https://ror.org/05jb9pq57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210163399']}, {'id': 'https://openalex.org/I4210100830', 'display_name': 'Shandong Tumor Hospital', 'ror': 'https://ror.org/01413r497', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100830']}, {'id': 'https://openalex.org/I154099455', 'display_name': 'Shandong University', 'ror': 'https://ror.org/0207yh398', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I154099455']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qisen Guo', 'raw_affiliation_strings': ['5Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China;'], 'affiliations': [{'raw_affiliation_string': '5Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China;', 'institution_ids': ['https://openalex.org/I4210163399', 'https://openalex.org/I4210100830', 'https://openalex.org/I154099455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052132950', 'display_name': 'Jianying Zhou', 'orcid': 'https://orcid.org/0000-0002-8924-935X'}, 'institutions': [{'id': 'https://openalex.org/I4210166576', 'display_name': 'First Affiliated Hospital Zhejiang University', 'ror': 'https://ror.org/05m1p5x56', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166576']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianying Zhou', 'raw_affiliation_strings': ['6The First Affiliated Hospital of Zhejiang University, Hangzhou, China;'], 'affiliations': [{'raw_affiliation_string': '6The First Affiliated Hospital of Zhejiang University, Hangzhou, China;', 'institution_ids': ['https://openalex.org/I4210166576']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057704753', 'display_name': 'Ying Cheng', 'orcid': 'https://orcid.org/0000-0001-9908-597X'}, 'institutions': [{'id': 'https://openalex.org/I4210098607', 'display_name': 'Jilin Province Tumor Hospital', 'ror': 'https://ror.org/00vgek070', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098607']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ying Cheng', 'raw_affiliation_strings': ['7Jilin Province Cancer Hospital, Changchun, China;'], 'affiliations': [{'raw_affiliation_string': '7Jilin Province Cancer Hospital, Changchun, China;', 'institution_ids': ['https://openalex.org/I4210098607']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055526321', 'display_name': 'Liyan Jiang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802608112', 'display_name': 'Shanghai Chest Hospital', 'ror': 'https://ror.org/03fjc3817', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802608112']}, {'id': 'https://openalex.org/I183067930', 'display_name': 'Shanghai Jiao Tong University', 'ror': 'https://ror.org/0220qvk04', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183067930']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liyan Jiang', 'raw_affiliation_strings': ['1Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China;'], 'affiliations': [{'raw_affiliation_string': '1Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China;', 'institution_ids': ['https://openalex.org/I2802608112', 'https://openalex.org/I183067930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100400883', 'display_name': 'Yuan Chen', 'orcid': 'https://orcid.org/0000-0001-8799-7664'}, 'institutions': [{'id': 'https://openalex.org/I47720641', 'display_name': 'Huazhong University of Science and Technology', 'ror': 'https://ror.org/00p991c53', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I47720641']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuan Chen', 'raw_affiliation_strings': ['8Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;'], 'affiliations': [{'raw_affiliation_string': '8Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;', 'institution_ids': ['https://openalex.org/I47720641', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023128001', 'display_name': 'Helong Zhang', 'orcid': 'https://orcid.org/0000-0001-8430-6071'}, 'institutions': [{'id': 'https://openalex.org/I9916479', 'display_name': 'Air Force Medical University', 'ror': 'https://ror.org/00ms48f15', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I9916479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Helong Zhang', 'raw_affiliation_strings': ['9Tangdu Hospital, The Fourth Military Medical University, Xi’an, China;'], 'affiliations': [{'raw_affiliation_string': '9Tangdu Hospital, The Fourth Military Medical University, Xi’an, China;', 'institution_ids': ['https://openalex.org/I9916479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006229890', 'display_name': 'Zongan Liang', 'orcid': 'https://orcid.org/0000-0002-8358-9177'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I4210089761', 'display_name': 'West China Hospital of Sichuan University', 'ror': 'https://ror.org/007mrxy13', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210089761']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zongan Liang', 'raw_affiliation_strings': ['10West China Hospital of Sichuan University, Chengdu, China;'], 'affiliations': [{'raw_affiliation_string': '10West China Hospital of Sichuan University, Chengdu, China;', 'institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I4210089761']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100327621', 'display_name': 'Xin Zhang', 'orcid': 'https://orcid.org/0000-0003-4298-7926'}, 'institutions': [{'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}, {'id': 'https://openalex.org/I4210127074', 'display_name': 'Zhongshan Hospital', 'ror': 'https://ror.org/032x22645', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210127074']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xin Zhang', 'raw_affiliation_strings': ['11Zhongshan Hospital, Fudan University, Shanghai, China;'], 'affiliations': [{'raw_affiliation_string': '11Zhongshan Hospital, Fudan University, Shanghai, China;', 'institution_ids': ['https://openalex.org/I24943067', 'https://openalex.org/I4210127074']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101811709', 'display_name': 'Wu B', 'orcid': 'https://orcid.org/0000-0003-4279-4921'}, 'institutions': [{'id': 'https://openalex.org/I4210148548', 'display_name': 'Fujian Provincial Cancer Hospital', 'ror': 'https://ror.org/058ms9w43', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210148548']}, {'id': 'https://openalex.org/I129708740', 'display_name': 'Fujian Medical University', 'ror': 'https://ror.org/050s6ns64', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I129708740']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Biao Wu', 'raw_affiliation_strings': ['12Fujian Provincial Cancer Hospital, The Affiliated Hospital of Fujian Medical University, Fuzhou, China;'], 'affiliations': [{'raw_affiliation_string': '12Fujian Provincial Cancer Hospital, The Affiliated Hospital of Fujian Medical University, Fuzhou, China;', 'institution_ids': ['https://openalex.org/I4210148548', 'https://openalex.org/I129708740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101154619', 'display_name': 'Jianhua Shi', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianhua Shi', 'raw_affiliation_strings': ['13Linyi Cancer Hospital, Linyi, China;'], 'affiliations': [{'raw_affiliation_string': '13Linyi Cancer Hospital, Linyi, China;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101973930', 'display_name': 'Hua Xu', 'orcid': 'https://orcid.org/0000-0001-9730-7276'}, 'institutions': [{'id': 'https://openalex.org/I4210108480', 'display_name': 'Second Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/01nxv5c88', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108480']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hua Xu', 'raw_affiliation_strings': ['14The Second Affiliated Hospital of Nanchang University, Nanchang, China;'], 'affiliations': [{'raw_affiliation_string': '14The Second Affiliated Hospital of Nanchang University, Nanchang, China;', 'institution_ids': ['https://openalex.org/I4210108480', 'https://openalex.org/I141649914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110375781', 'display_name': 'Jianjin Huang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210158318', 'display_name': 'Second Affiliated Hospital of Zhejiang University', 'ror': 'https://ror.org/059cjpv64', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158318']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianjin Huang', 'raw_affiliation_strings': ['15The Second Affiliated Hospital of Zhejiang University, Hangzhou, China;'], 'affiliations': [{'raw_affiliation_string': '15The Second Affiliated Hospital of Zhejiang University, Hangzhou, China;', 'institution_ids': ['https://openalex.org/I4210158318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101493023', 'display_name': 'Zhixiong Yang', 'orcid': 'https://orcid.org/0000-0002-8362-6644'}, 'institutions': [{'id': 'https://openalex.org/I176834541', 'display_name': 'Guangdong Medical College', 'ror': 'https://ror.org/04k5rxe29', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I176834541']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhixiong Yang', 'raw_affiliation_strings': ['16Affiliated Hospital of Guangdong Medical College, Zhanjiang, China;'], 'affiliations': [{'raw_affiliation_string': '16Affiliated Hospital of Guangdong Medical College, Zhanjiang, China;', 'institution_ids': ['https://openalex.org/I176834541']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087809584', 'display_name': 'Shan Zeng', 'orcid': 'https://orcid.org/0000-0002-0988-723X'}, 'institutions': [{'id': 'https://openalex.org/I4210159865', 'display_name': 'Xiangya Hospital Central South University', 'ror': 'https://ror.org/05c1yfj14', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210159865']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shan Zeng', 'raw_affiliation_strings': ['17Xiangya Hospital, Central South University, Changsha, China;'], 'affiliations': [{'raw_affiliation_string': '17Xiangya Hospital, Central South University, Changsha, China;', 'institution_ids': ['https://openalex.org/I4210159865', 'https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057848878', 'display_name': 'Yanping Hu', 'orcid': 'https://orcid.org/0000-0001-7128-2648'}, 'institutions': [{'id': 'https://openalex.org/I4210160841', 'display_name': 'Hubei Cancer Hospital', 'ror': 'https://ror.org/05p38yh32', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160841']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanping Hu', 'raw_affiliation_strings': ['18Hubei Cancer Hospital, Wuhan, China;'], 'affiliations': [{'raw_affiliation_string': '18Hubei Cancer Hospital, Wuhan, China;', 'institution_ids': ['https://openalex.org/I4210160841']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077277862', 'display_name': 'Xiaodong Zhang', 'orcid': 'https://orcid.org/0000-0002-7212-0138'}, 'institutions': [{'id': 'https://openalex.org/I4210105390', 'display_name': 'Nantong Tumor Hospital', 'ror': 'https://ror.org/01egmr022', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105390']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaodong Zhang', 'raw_affiliation_strings': ['19Nantong Tumor Hospital, Nantong, China;'], 'affiliations': [{'raw_affiliation_string': '19Nantong Tumor Hospital, Nantong, China;', 'institution_ids': ['https://openalex.org/I4210105390']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104086241', 'display_name': 'Jingxun Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210087327', 'display_name': 'First Affiliated Hospital of Xiamen University', 'ror': 'https://ror.org/0006swh35', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087327']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jingxun Wu', 'raw_affiliation_strings': ['20The First Affiliated Hospital of Xiamen University, Xiamen, China;'], 'affiliations': [{'raw_affiliation_string': '20The First Affiliated Hospital of Xiamen University, Xiamen, China;', 'institution_ids': ['https://openalex.org/I4210087327']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109716707', 'display_name': 'Gongyan Chen', 'orcid': 'https://orcid.org/0009-0003-8805-8812'}, 'institutions': [{'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}, {'id': 'https://openalex.org/I4210103956', 'display_name': 'Third Affiliated Hospital of Harbin Medical University', 'ror': 'https://ror.org/01f77gp95', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103956']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Gongyan Chen', 'raw_affiliation_strings': ['21Cancer Hospital of Harbin Medical University, Harbin, China;'], 'affiliations': [{'raw_affiliation_string': '21Cancer Hospital of Harbin Medical University, Harbin, China;', 'institution_ids': ['https://openalex.org/I156144747', 'https://openalex.org/I4210103956']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076756498', 'display_name': 'Nong Yang', 'orcid': 'https://orcid.org/0000-0003-0997-3645'}, 'institutions': [{'id': 'https://openalex.org/I4210115624', 'display_name': 'Hunan Cancer Hospital', 'ror': 'https://ror.org/025020z88', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115624']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Nong Yang', 'raw_affiliation_strings': ['22Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China;'], 'affiliations': [{'raw_affiliation_string': '22Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China;', 'institution_ids': ['https://openalex.org/I4210115624', 'https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047498651', 'display_name': 'Longzhen Zhang', 'orcid': 'https://orcid.org/0000-0002-5786-1560'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Longzhen Zhang', 'raw_affiliation_strings': ['23The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China;'], 'affiliations': [{'raw_affiliation_string': '23The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China;', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056824495', 'display_name': 'Yinjia Fu', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yinjia Fu', 'raw_affiliation_strings': ['24Hutchison MediPharma Limited, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': '24Hutchison MediPharma Limited, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100337020', 'display_name': 'Jing Li', 'orcid': 'https://orcid.org/0000-0002-9237-1962'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Li', 'raw_affiliation_strings': ['24Hutchison MediPharma Limited, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': '24Hutchison MediPharma Limited, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101962639', 'display_name': 'Linfang Wang', 'orcid': 'https://orcid.org/0000-0003-0905-4390'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Linfang Wang', 'raw_affiliation_strings': ['24Hutchison MediPharma Limited, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': '24Hutchison MediPharma Limited, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059732688', 'display_name': 'Yongxin Ren', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yongxin Ren', 'raw_affiliation_strings': ['24Hutchison MediPharma Limited, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': '24Hutchison MediPharma Limited, Shanghai, China.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112041601', 'display_name': 'Weiguo Su', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weiguo Su', 'raw_affiliation_strings': ['24Hutchison MediPharma Limited, Shanghai, China.'], 'affiliations': [{'raw_affiliation_string': '24Hutchison MediPharma Limited, Shanghai, China.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 33, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.745, 'has_fulltext': False, 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.8743, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '79', 'issue': '13_Supplement', 'first_page': 'CT031', 'last_page': 'CT031'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12992', 'display_name': 'Metastasis and carcinoma case studies', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12992', 'display_name': 'Metastasis and carcinoma case studies', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12379', 'display_name': 'Cancer Diagnosis and Treatment', 'score': 0.9654, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Cancer Research and Treatments', 'score': 0.9429, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.52430665}, {'id': 'https://openalex.org/keywords/regimen', 'display_name': 'Regimen', 'score': 0.5206991}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.84088755}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6860047}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.54155946}, {'id': 'https://openalex.org/C2779634585', 'wikidata': 'https://www.wikidata.org/wiki/Q1334541', 'display_name': 'Pleural effusion', 'level': 2, 'score': 0.53656214}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.52430665}, {'id': 'https://openalex.org/C2781413609', 'wikidata': 'https://www.wikidata.org/wiki/Q7308373', 'display_name': 'Regimen', 'level': 2, 'score': 0.5206991}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.51251173}, {'id': 'https://openalex.org/C2779177807', 'wikidata': 'https://www.wikidata.org/wiki/Q3658562', 'display_name': 'non-small cell lung cancer (NSCLC)', 'level': 4, 'score': 0.47712708}, {'id': 'https://openalex.org/C2778822529', 'wikidata': 'https://www.wikidata.org/wiki/Q1951525', 'display_name': 'Progressive disease', 'level': 3, 'score': 0.4437214}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.44163352}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.3874472}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.2734478}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.2553237}, {'id': 'https://openalex.org/C81729549', 'wikidata': 'https://www.wikidata.org/wiki/Q4649475', 'display_name': 'A549 cell', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-ct031', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.75}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4310603196', 'https://openalex.org/W2412005057', 'https://openalex.org/W2410163895', 'https://openalex.org/W2394784562', 'https://openalex.org/W2386504342', 'https://openalex.org/W2384274503', 'https://openalex.org/W2377136501', 'https://openalex.org/W2351826232', 'https://openalex.org/W2214021454', 'https://openalex.org/W2009096079'], 'abstract_inverted_index': {'Abstract': [0], 'Introduction:': [1], 'MET': [2, 33, 60, 88, 164, 399, 501], 'mutations': [3, 92, 505], 'have': [4, 362], 'been': [5, 260], 'linked': [6], 'with': [7, 77, 163, 228, 274, 398, 486], 'highly': [8, 31], 'progressive': [9], 'clinical': [10], 'behaviors': [11], 'and': [12, 25, 35, 55, 169, 186, 207, 244, 323, 336, 377, 389, 479, 491], 'poor': [13], 'prognosis': [14], 'in': [15, 37, 59, 94, 396, 412], 'several': [16], 'tumor': [17], 'types.': [18], 'Savolitinib': [19, 113], '(also': [20], 'known': [21], 'as': [22, 271], 'AZD6094,': [23], 'HMPL-504': [24], 'volitinib)': [26], 'is': [27, 42, 415], 'a': [28], 'novel,': [29], 'potent,': [30], 'selective': [32], 'inhibitor': [34], 'investigated': [36], 'solid': [38], 'tumors.': [39], 'Methods:': [40], 'This': [41], 'an': [43, 390], 'open-label,': [44], 'single': [45], 'arm,': [46], 'multi-center': [47], 'phase': [48], 'II': [49], 'study': [50, 414], 'to': [51, 106, 213, 232, 251, 343, 352, 372], 'evaluate': [52], 'the': [53, 141, 266, 285, 299, 510], 'efficacy': [54, 248, 478], 'safety': [56, 392, 480], 'of': [57, 69, 85, 148, 177, 216, 394, 407, 410, 482, 494, 509], 'savolitinib': [58, 395, 483], 'exon': [61, 89, 165, 400, 502], '14': [62, 90, 166, 401, 503], 'skipping': [63, 91, 167, 504], 'mutant': [64], 'PSC': [65, 81, 403], 'or': [66, 79, 82, 156, 404], 'other': [67, 83, 175, 405, 492], 'types': [68, 84, 176, 406, 493], 'NSCLC': [70, 86], '(NCT02897479).': [71], 'Eligible': [72], 'patients': [73, 485], '(pts)': [74], 'were': [75, 154, 189, 199, 247, 309], 'diagnosed': [76], 'unresectable': [78], 'metastatic': [80], 'harboring': [87, 500], 'identified': [93, 101], 'tumor,': [95], 'plasma': [96], 'and/or': [97], 'pleural': [98], 'effusion.': [99], 'Mutations': [100], 'by': [102, 109, 158], 'local': [103], 'lab': [104, 111], 'required': [105], 'be': [107, 233], 'confirmed': [108, 157, 222, 234, 267, 286], 'central': [110, 159], 'test.': [112], '600mg': [114], 'was': [115, 126, 181, 270, 289, 355], 'taken': [116], 'orally,': [117], 'once': [118], 'daily,': [119], 'until': [120], 'disease': [121, 242], 'progression.': [122], 'The': [123, 254, 346], 'primary': [124, 379], 'endpoint': [125], 'objective': [127], 'response': [128], 'rate': [129], '(ORR)': [130], 'per': [131], 'RECIST': [132], 'version': [133], '1.1.': [134], 'Here': [135], 'we': [136], 'report': [137], 'interim': [138], 'results': [139, 481], 'after': [140], 'first': [142], '34': [143, 170, 297], 'enrolled': [144], 'pts.': [145], 'Results:': [146], 'As': [147], '17': [149, 197], 'December': [150], '2018,': [151], '315': [152], 'pts': [153, 188, 198, 203, 209, 220, 227, 246, 257, 269, 288, 329, 339, 361, 397], 'prescreened': [155], 'lab,': [160], '49': [161], 'identified/confirmed': [162], 'mutations,': [168], 'treated': [171], '(14': [172], 'PSC;': [173], '20': [174], 'NSCLC).': [178], 'Median': [179, 281], 'age': [180], '69': [182], 'years': [183], '(range': [184], '54-85)': [185], '68%': [187], 'male.': [190], 'Prior': [191], 'antitumor': [192, 387], 'drugs': [193], 'for': [194, 265, 284, 513], 'advanced': [195], 'disease:': [196], 'treatment': [200, 282, 304, 341, 353, 373], 'naïve,': [201], '13': [202], 'received': [204], '1': [205, 278, 369, 378], 'regimen,': [206], '4': [208, 226], '≥2': [210], 'regimens.': [211], 'According': [212], 'investigators’': [214], 'assessment': [215], '31': [217], 'patients,': [218], '12': [219, 327], 'had': [221, 237, 241, 258, 330], 'partial': [223], 'responses': [224], '(PR);': [225], 'newly': [229], 'reported,': [230], 'yet': [231], 'PRs;': [235], '10': [236], 'stable': [238], 'disease;': [239], '2': [240], 'progression;': [243], '3': [245, 256, 333, 365], 'non-evaluable': [249], 'due': [250, 342], 'early': [252], 'discontinuation.': [253], 'remaining': [255], 'not': [259], 'evaluated': [261], 'yet.': [262], 'Tumor': [263], 'histology': [264], 'PR': [268, 287], 'follows:': [272], '6': [273], 'PSC,': [275], '5': [276, 337], 'adenocarcinoma,': [277], 'adenosquamous': [279], 'carcinoma.': [280], 'duration': [283], '34+': [290], 'weeks': [291], '(range:': [292], '16-96+': [293], 'weeks).': [294], 'Among': [295], 'all': [296], 'pts,': [298], 'most': [300, 347], 'common': [301, 348], '(≥20%)': [302], 'drug-related': [303], 'emergent': [305], 'adverse': [306], 'events': [307], '(TEAEs)': [308], 'nausea': [310], '(41%),': [311], 'edema': [312], 'peripheral': [313], '(38%),': [314], 'alanine': [315], 'aminotransferase': [316, 320], 'increased': [317, 321], '(32%),': [318], 'aspartate': [319], '(29%)': [322], 'vomiting': [324], '(21%).': [325], 'Overall,': [326], '(35%)': [328], '≥': [331], 'grade': [332], 'related': [334, 344, 349, 367, 371], 'TEAEs,': [335], '(15%)': [338], 'discontinued': [340], 'TEAEs.': [345], 'TEAE': [350], 'leading': [351], 'discontinuation': [354], 'drug-induced': [356], 'liver': [357], 'toxicity': [358], '(6%).': [359], 'Five': [360], 'died': [363], 'on-treatment:': [364], 'unrelated/unlikely': [366], 'AEs,': [368], 'probably': [370], '(tumor': [374], 'lysis': [375], 'syndrome),': [376], 'cause': [380], 'unknown.': [381], 'Conclusion:': [382], 'Preliminary': [383, 477], 'data': [384], 'suggested': [385], 'encouraging': [386], 'activity': [388], 'acceptable': [391], 'profile': [393], 'mutated': [402], 'NSCLC.': [408], 'Accrual': [409], 'subjects': [411], 'this': [413], 'ongoing.': [416], 'Citation': [417], 'Format:': [418], 'Shun': [419], 'Lu,': [420], 'Jian': [421], 'Fang,': [422], 'Lejie': [423], 'Cao,': [424], 'Xingya': [425], 'Li,': [426, 470], 'Qisen': [427], 'Guo,': [428], 'Jianying': [429], 'Zhou,': [430], 'Ying': [431], 'Cheng,': [432], 'Liyan': [433], 'Jiang,': [434], 'Yuan': [435], 'Chen,': [436, 462], 'Helong': [437], 'Zhang,': [438, 442, 458, 466], 'Zongan': [439], 'Liang,': [440], 'Xin': [441], 'Biao': [443], 'Wu,': [444, 460], 'Jianhua': [445], 'Shi,': [446], 'Hua': [447], 'Xu,': [448], 'Jianjin': [449], 'Huang,': [450], 'Zhixiong': [451], 'Yang,': [452, 464], 'Shan': [453], 'Zeng,': [454], 'Yanping': [455], 'Hu,': [456], 'Xiaodong': [457], 'Jingxun': [459], 'Gongyan': [461], 'Nong': [463], 'Longzhen': [465], 'Yinjia': [467], 'Fu,': [468], 'Jing': [469], 'Linfang': [471], 'Wang,': [472], 'Yongxin': [473], 'Ren,': [474], 'Weiguo': [475], 'Su.': [476], 'treating': [484], 'pulmonary': [487], 'sarcomatoid': [488], 'carcinoma': [489], '(PSC)': [490], 'non-small': [495], 'cell': [496], 'lung': [497], 'cancer': [498], '(NSCLC)': [499], '[abstract].': [506], 'In:': [507], 'Proceedings': [508], 'American': [511], 'Association': [512], 'Cancer': [514, 528], 'Research': [515], 'Annual': [516], 'Meeting': [517], '2019;': [518], '2019': [519], 'Mar': [520], '29-Apr': [521], '3;': [522], 'Atlanta,': [523], 'GA.': [524], 'Philadelphia': [525], '(PA):': [526], 'AACR;': [527], 'Res': [529], '2019;79(13': [530], 'Suppl):Abstract': [531], 'nr': [532], 'CT031.': [533]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2954952522', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 13}], 'updated_date': '2025-01-12T14:13:09.273596', 'created_date': '2019-07-12'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
