Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2954466382', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-ct075', 'title': 'Abstract CT075: Phase I evaluation of M7824, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus (HPV)-associated malignancies', 'display_name': 'Abstract CT075: Phase I evaluation of M7824, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus (HPV)-associated malignancies', 'publication_year': 2019, 'publication_date': '2019-07-01', 'ids': {'openalex': 'https://openalex.org/W2954466382', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-ct075', 'mag': '2954466382'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-ct075', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033345547', 'display_name': 'Julius Strauss', 'orcid': 'https://orcid.org/0000-0002-7550-4938'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julius Strauss', 'raw_affiliation_strings': ['1Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;'], 'affiliations': [{'raw_affiliation_string': '1Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022515427', 'display_name': 'Margaret E. Gatti‐Mays', 'orcid': 'https://orcid.org/0000-0001-8914-2897'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Margaret E. Gatti-Mays', 'raw_affiliation_strings': ['1Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;'], 'affiliations': [{'raw_affiliation_string': '1Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065142755', 'display_name': 'Byoung Cho', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Byoung Cho', 'raw_affiliation_strings': ['2Yonsei University College of Medicine, Seoul, Republic of Korea;'], 'affiliations': [{'raw_affiliation_string': '2Yonsei University College of Medicine, Seoul, Republic of Korea;', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045172802', 'display_name': 'Sébastien Salas', 'orcid': 'https://orcid.org/0000-0001-6222-5027'}, 'institutions': [{'id': 'https://openalex.org/I4210087487', 'display_name': 'Assistance Publique Hôpitaux de Marseille', 'ror': 'https://ror.org/002cp4060', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087487']}, {'id': 'https://openalex.org/I21491767', 'display_name': 'Aix-Marseille Université', 'ror': 'https://ror.org/035xkbk20', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I21491767']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Sébastien Salas', 'raw_affiliation_strings': ['3CEPCM Assistance Publique des Hôpitaux de Marseille; Aix-Marseille University, Marseille, France;'], 'affiliations': [{'raw_affiliation_string': '3CEPCM Assistance Publique des Hôpitaux de Marseille; Aix-Marseille University, Marseille, France;', 'institution_ids': ['https://openalex.org/I4210087487', 'https://openalex.org/I21491767']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062081483', 'display_name': 'Edward F. McClay', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210093243', 'display_name': 'California Cancer Associates for Research and Excellence', 'ror': 'https://ror.org/00jw0jd04', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edward McClay', 'raw_affiliation_strings': ['4California Cancer Associates for Research and Excellence, Encinitas, CA;'], 'affiliations': [{'raw_affiliation_string': '4California Cancer Associates for Research and Excellence, Encinitas, CA;', 'institution_ids': ['https://openalex.org/I4210093243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089085223', 'display_name': 'Jason Redman', 'orcid': 'https://orcid.org/0000-0001-8200-0167'}, 'institutions': [{'id': 'https://openalex.org/I4210091794', 'display_name': 'Office of the Director', 'ror': 'https://ror.org/00fj8a872', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210091794']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jason Redman', 'raw_affiliation_strings': ['5Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;'], 'affiliations': [{'raw_affiliation_string': '5Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;', 'institution_ids': ['https://openalex.org/I4210091794', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074041292', 'display_name': 'Houssein Abdul Sater', 'orcid': 'https://orcid.org/0000-0003-1975-3726'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Houssein Abdul Sater', 'raw_affiliation_strings': ['6Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;'], 'affiliations': [{'raw_affiliation_string': '6Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052157883', 'display_name': 'Renee N. Donahue', 'orcid': 'https://orcid.org/0000-0002-6828-3073'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Renee N. Donahue', 'raw_affiliation_strings': ['1Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;'], 'affiliations': [{'raw_affiliation_string': '1Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002165632', 'display_name': 'Elizabeth Lamping', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091794', 'display_name': 'Office of the Director', 'ror': 'https://ror.org/00fj8a872', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210091794']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth Lamping', 'raw_affiliation_strings': ['5Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;'], 'affiliations': [{'raw_affiliation_string': '5Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;', 'institution_ids': ['https://openalex.org/I4210091794', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049683415', 'display_name': 'Andrea Burmeister', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrea Burmeister', 'raw_affiliation_strings': ['1Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;'], 'affiliations': [{'raw_affiliation_string': '1Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029480834', 'display_name': 'Jennifer L. Marté', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer L. Marté', 'raw_affiliation_strings': ['6Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;'], 'affiliations': [{'raw_affiliation_string': '6Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040286491', 'display_name': 'Lisa Cordes', 'orcid': 'https://orcid.org/0000-0003-3833-4084'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lisa Cordes', 'raw_affiliation_strings': ['6Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;'], 'affiliations': [{'raw_affiliation_string': '6Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032175106', 'display_name': 'Laureen S. Ojalvo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210098679', 'display_name': 'Ono Pharmaceutical (United States)', 'ror': 'https://ror.org/010xeam31', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210098679', 'https://openalex.org/I4210112155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laureen S. Ojalvo', 'raw_affiliation_strings': ['7Immuno-Oncology, EMD Serono, Billerica, MA;'], 'affiliations': [{'raw_affiliation_string': '7Immuno-Oncology, EMD Serono, Billerica, MA;', 'institution_ids': ['https://openalex.org/I4210098679']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043165289', 'display_name': 'Christoph Helwig', 'orcid': 'https://orcid.org/0000-0003-4916-9918'}, 'institutions': [{'id': 'https://openalex.org/I164928964', 'display_name': 'Merck (Germany)', 'ror': 'https://ror.org/04b2dty93', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I164928964']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christoph Helwig', 'raw_affiliation_strings': ['8Merck KGaA, Darmstadt, Germany;'], 'affiliations': [{'raw_affiliation_string': '8Merck KGaA, Darmstadt, Germany;', 'institution_ids': ['https://openalex.org/I164928964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003236441', 'display_name': 'Alex Rolfe', 'orcid': 'https://orcid.org/0000-0003-3540-1843'}, 'institutions': [{'id': 'https://openalex.org/I4210098679', 'display_name': 'Ono Pharmaceutical (United States)', 'ror': 'https://ror.org/010xeam31', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210098679', 'https://openalex.org/I4210112155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alex Rolfe', 'raw_affiliation_strings': ['9EMD Serono, Billerica, MA;'], 'affiliations': [{'raw_affiliation_string': '9EMD Serono, Billerica, MA;', 'institution_ids': ['https://openalex.org/I4210098679']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066468457', 'display_name': 'Christian S. Hinrichs', 'orcid': 'https://orcid.org/0000-0001-5597-2841'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christian S. Hinrichs', 'raw_affiliation_strings': ['10Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.'], 'affiliations': [{'raw_affiliation_string': '10Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044285326', 'display_name': 'Ravi A. Madan', 'orcid': 'https://orcid.org/0000-0001-5106-8636'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ravi A. Madan', 'raw_affiliation_strings': ['6Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;'], 'affiliations': [{'raw_affiliation_string': '6Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059931764', 'display_name': 'Jeffrey Schlom', 'orcid': 'https://orcid.org/0000-0001-7932-4072'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey Schlom', 'raw_affiliation_strings': ['1Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;'], 'affiliations': [{'raw_affiliation_string': '1Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070669850', 'display_name': 'James L. Gulley', 'orcid': 'https://orcid.org/0000-0002-6569-2912'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James Gulley', 'raw_affiliation_strings': ['6Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;'], 'affiliations': [{'raw_affiliation_string': '6Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210149717']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 10, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.145, 'has_fulltext': False, 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.716583, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '79', 'issue': '13_Supplement', 'first_page': 'CT075', 'last_page': 'CT075'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12422', 'display_name': 'Radiomics in Medical Imaging Analysis', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12422', 'display_name': 'Radiomics in Medical Imaging Analysis', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11501', 'display_name': 'Transforming Growth Factor Beta Signaling Pathway', 'score': 0.9533, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13110', 'display_name': 'Treatment and Management of Anal Cancer', 'score': 0.9227, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tumor-heterogeneity', 'display_name': 'Tumor Heterogeneity', 'score': 0.521816}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.85664773}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.59326804}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.57335186}, {'id': 'https://openalex.org/C72563966', 'wikidata': 'https://www.wikidata.org/wiki/Q1303415', 'display_name': 'Cohort', 'level': 2, 'score': 0.5491068}, {'id': 'https://openalex.org/C2778822529', 'wikidata': 'https://www.wikidata.org/wiki/Q1951525', 'display_name': 'Progressive disease', 'level': 3, 'score': 0.4887259}, {'id': 'https://openalex.org/C2779984678', 'wikidata': 'https://www.wikidata.org/wiki/Q2145898', 'display_name': 'Response Evaluation Criteria in Solid Tumors', 'level': 4, 'score': 0.44853407}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.42906186}, {'id': 'https://openalex.org/C31760486', 'wikidata': 'https://www.wikidata.org/wiki/Q7180990', 'display_name': 'Phases of clinical research', 'level': 3, 'score': 0.42545766}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.42335045}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.37627906}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.35460353}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3141736}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.23581332}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-ct075', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.86}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3197516152', 'https://openalex.org/W3175985098', 'https://openalex.org/W2738397398', 'https://openalex.org/W2592111180', 'https://openalex.org/W2518309888', 'https://openalex.org/W2511317369', 'https://openalex.org/W2356001539', 'https://openalex.org/W2351330346', 'https://openalex.org/W1964812149', 'https://openalex.org/W127506674'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'TGF-β': [2, 60, 456], 'pathway': [3, 35], 'dysregulation': [4], 'may': [5, 36], 'play': [6], 'a': [7, 64, 213, 224, 242, 251, 354, 375, 451], 'critical': [8], 'role': [9], 'in': [10, 15, 135, 149, 363, 387, 459], 'carcinogenesis': [11], 'and': [12, 22, 30, 103, 173, 187, 266, 311, 346, 348, 358, 382, 390, 457], 'immune': [13, 91], 'evasion': [14], 'HPV-associated': [16], 'cancers': [17], '(HACs),': [18], 'including': [19], 'anal,': [20], 'cervical,': [21], 'p16+': [23], 'squamous': [24], 'cell': [25], 'carcinoma': [26], 'of': [27, 53, 57, 75, 81, 146, 184, 193, 216, 278, 449, 469], 'the': [28, 72, 76, 112, 136, 141, 150, 181, 185, 470], 'head': [29], 'neck': [31], '(SCCHN).': [32], 'Targeting': [33], 'this': [34], 'also': [37], 'enhance': [38], 'clinical': [39, 97, 258, 361, 369], 'response': [40, 92, 176, 225, 230, 234, 259, 279, 370], 'to': [41, 339], 'PD-(L)1': [42], 'antibodies.': [43], 'M7824': [44, 82, 94, 130, 211, 337, 352, 373], 'is': [45, 374, 383], 'an': [46, 89, 272], 'innovative': [47], 'first-in-class': [48], 'bifunctional': [49, 452], 'fusion': [50, 453], 'protein': [51, 454], 'composed': [52], 'two': [54], 'extracellular': [55], 'domains': [56], 'TGF-βRII': [58], '(a': [59], '“trap”)': [61], 'fused': [62], 'with': [63, 85, 108, 116, 124, 199, 264, 269, 316, 365, 461], 'human': [65, 462], 'IgG1': [66], 'monoclonal': [67], 'antibody': [68], 'against': [69], 'PD-L1.': [70], 'In': [71], 'dose-escalation': [73, 113, 137, 186], 'cohort': [74, 114], 'ongoing': [77, 273], 'Phase': [78, 446], 'I': [79, 447], 'trial': [80, 162], '(NCT02517398),': [83], 'patients': [84, 107, 123, 198, 222, 249, 263, 268, 287, 333, 364, 381, 460], 'HACs': [86, 202, 367], 'who': [87], 'developed': [88, 241], 'HPV-specific': [90], 'on': [93], 'had': [95, 209, 223, 250, 289, 318], 'improved': [96], 'responses.': [98], 'Here': [99], 'we': [100], 'report': [101], 'efficacy': [102, 362], 'safety': [104, 356], 'data': [105, 117, 245], 'from': [106, 111, 118], 'HPV-positive': [109, 125, 201, 366], 'malignancies': [110, 465], 'pooled': [115], 'HAC': [119], 'expansion': [120, 151, 188], 'cohorts': [121], 'for': [122, 212, 379, 473], 'disease.': [126], 'Methods:': [127], 'Patients': [128], 'received': [129, 210], 'Q2W': [131], 'at': [132, 140], '1-30': [133], 'mg/kg': [134], 'phase': [138, 143, 388], 'or': [139, 161], 'recommended': [142], '2': [144, 391], 'dose': [145], '1200': [147], 'mg': [148], 'cohorts.': [152], 'Treatment': [153], 'continued': [154], 'until': [155], 'progressive': [156], 'disease': [157], '(PD),': [158], 'unacceptable': [159], 'toxicity,': [160], 'withdrawal;': [163], 'treatment': [164], 'past': [165], 'PD': [166, 256], 'was': [167, 280], 'allowed': [168], 'if': [169], 'clinically': [170], 'justified.': [171], 'Safety': [172], 'best': [174], 'overall': [175], 'by': [177], 'RECIST': [178], 'v1.1': [179], 'were': [180], 'primary': [182], 'endpoints': [183], 'phases,': [189], 'respectively.': [190], 'Results:': [191], 'As': [192], 'August': [194], '24,': [195], '2018,': [196], '36': [197], 'pretreated': [200], '(4': [203], 'anal;': [204], '18': [205], 'cervical;': [206], '14': [207], 'SCCHN)': [208], 'median': [214, 276], 'duration': [215, 277], '19.0': [217], 'weeks': [218], '(range,': [219, 283], '2.0-96.0).': [220], '10': [221], 'per': [226], 'investigator': [227], '(2': [228], 'complete': [229], '[CR];': [231], '8': [232], 'partial': [233], '[PR];': [235], 'ORR': [236], '27.8%).': [237], '1': [238], 'additional': [239, 248], 'patient': [240, 315], 'PR': [243, 253, 270], 'after': [244, 254], 'cutoff;': [246], '3': [247, 291], 'delayed': [252], 'initial': [255], '(total': [257, 368], 'rate': [260, 371], '38.9%).': [261, 372], 'Both': [262], 'CR': [265], '5': [267], 'have': [271], 'response.': [274], 'The': [275, 314], 'not': [281], 'reached': [282], '4-22+': [284], 'months).': [285], '9': [286], '(25%)': [288], 'grade': [290, 320, 324], 'treatment-related': [292, 329], 'adverse': [293], 'events': [294], '(TRAE):': [295], 'anemia,': [296], 'cystitis,': [297, 344], 'diabetic': [298], 'ketoacidosis,': [299], 'increased': [300], 'γ-glutamyltransferase,': [301], 'gastroparesis,': [302], 'hyperkeratosis,': [303], 'hypokalemia,': [304], 'keratoacanthoma,': [305], 'macular': [306], 'rash,': [307], 'pleural': [308], 'effusion,': [309], 'pneumonitis,': [310, 345], 'skin': [312], 'SCC.': [313], 'gastroparesis': [317], 'asymptomatic': [319], '3→4': [321], 'hypokalemia': [322], '(1': [323], '4': [325], 'TRAE,': [326], '2.7%).': [327], 'No': [328], 'deaths': [330], 'occurred.': [331], '6': [332], '(16.7%)': [334], 'permanently': [335], 'discontinued': [336], 'due': [338], 'TRAEs': [340], '(gastroparesis,': [341], 'infusion-related': [342], 'reaction,': [343], 'acneiform': [347], 'psoriasiform': [349], 'dermatitis).': [350], 'Conclusions:': [351], 'has': [353], 'manageable': [355], 'profile': [357], 'shows': [359], 'encouraging': [360], 'promising': [376], 'therapeutic': [377], 'agent': [378], 'these': [380], 'under': [384], 'further': [385], 'evaluation': [386, 448], '1b': [389], 'trials.': [392], 'Updated': [393], 'survival': [394], 'results': [395], 'will': [396], 'be': [397], 'reported.': [398], 'Citation': [399], 'Format:': [400], 'Julius': [401], 'Strauss,': [402], 'Margaret': [403], 'E.': [404], 'Gatti-Mays,': [405], 'Byoung': [406], 'Cho,': [407], 'Sébastien': [408], 'Salas,': [409], 'Edward': [410], 'McClay,': [411], 'Jason': [412], 'Redman,': [413], 'Houssein': [414], 'Abdul': [415], 'Sater,': [416], 'Renee': [417], 'N.': [418], 'Donahue,': [419], 'Elizabeth': [420], 'Lamping,': [421], 'Andrea': [422], 'Burmeister,': [423], 'Jennifer': [424], 'L.': [425], 'Marté,': [426], 'Lisa': [427], 'Cordes,': [428], 'Laureen': [429], 'S.': [430, 437], 'Ojalvo,': [431], 'Christoph': [432], 'Helwig,': [433], 'Alex': [434], 'Rolfe,': [435], 'Christian': [436], 'Hinrichs,': [438], 'Ravi': [439], 'A.': [440], 'Madan,': [441], 'Jeffrey': [442], 'Schlom,': [443], 'James': [444], 'Gulley.': [445], 'M7824,': [450], 'targeting': [455], 'PD-L1,': [458], 'papillomavirus': [463], '(HPV)-associated': [464], '[abstract].': [466], 'In:': [467], 'Proceedings': [468], 'American': [471], 'Association': [472], 'Cancer': [474, 488], 'Research': [475], 'Annual': [476], 'Meeting': [477], '2019;': [478], '2019': [479], 'Mar': [480], '29-Apr': [481], '3;': [482], 'Atlanta,': [483], 'GA.': [484], 'Philadelphia': [485], '(PA):': [486], 'AACR;': [487], 'Res': [489], '2019;79(13': [490], 'Suppl):Abstract': [491], 'nr': [492], 'CT075.': [493]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2954466382', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 8}], 'updated_date': '2024-09-25T20:02:30.834583', 'created_date': '2019-07-12'}