Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2953584706', 'doi': 'https://doi.org/10.1128/mcb.00203-19', 'title': 'Formation of tRNA Wobble Inosine in Humans Is Disrupted by a Millennia-Old Mutation Causing Intellectual Disability', 'display_name': 'Formation of tRNA Wobble Inosine in Humans Is Disrupted by a Millennia-Old Mutation Causing Intellectual Disability', 'publication_year': 2019, 'publication_date': '2019-10-01', 'ids': {'openalex': 'https://openalex.org/W2953584706', 'doi': 'https://doi.org/10.1128/mcb.00203-19', 'mag': '2953584706', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31263000', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6751630'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.00203-19', 'pdf_url': 'https://mcb.asm.org/content/mcb/39/19/e00203-19.full.pdf', 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://mcb.asm.org/content/mcb/39/19/e00203-19.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5073318315', 'display_name': 'Jillian Ramos', 'orcid': 'https://orcid.org/0000-0001-8139-5793'}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}, {'id': 'https://openalex.org/I28792581', 'display_name': 'University of Rochester Medical Center', 'ror': 'https://ror.org/00trqv719', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I28792581', 'https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jillian Ramos', 'raw_affiliation_strings': ['Center for RNA Biology, University of Rochester and University of Rochester Medical Center, Rochester, New York, USA', 'Department of Biology, University of Rochester, Rochester, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, University of Rochester, Rochester, New York, USA', 'institution_ids': ['https://openalex.org/I5388228']}, {'raw_affiliation_string': 'Center for RNA Biology, University of Rochester and University of Rochester Medical Center, Rochester, New York, USA', 'institution_ids': ['https://openalex.org/I28792581']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101914722', 'display_name': 'Lu Han', 'orcid': 'https://orcid.org/0000-0001-6847-2993'}, 'institutions': [{'id': 'https://openalex.org/I28792581', 'display_name': 'University of Rochester Medical Center', 'ror': 'https://ror.org/00trqv719', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I28792581', 'https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lu Han', 'raw_affiliation_strings': ['Center for RNA Biology, University of Rochester and University of Rochester Medical Center, Rochester, New York, USA', 'Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York, USA', 'institution_ids': ['https://openalex.org/I28792581']}, {'raw_affiliation_string': 'Center for RNA Biology, University of Rochester and University of Rochester Medical Center, Rochester, New York, USA', 'institution_ids': ['https://openalex.org/I28792581']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100380449', 'display_name': 'Yan Li', 'orcid': 'https://orcid.org/0000-0003-4962-9910'}, 'institutions': [{'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}, {'id': 'https://openalex.org/I28792581', 'display_name': 'University of Rochester Medical Center', 'ror': 'https://ror.org/00trqv719', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I28792581', 'https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yan Li', 'raw_affiliation_strings': ['Center for RNA Biology, University of Rochester and University of Rochester Medical Center, Rochester, New York, USA', 'Department of Biology, University of Rochester, Rochester, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, University of Rochester, Rochester, New York, USA', 'institution_ids': ['https://openalex.org/I5388228']}, {'raw_affiliation_string': 'Center for RNA Biology, University of Rochester and University of Rochester Medical Center, Rochester, New York, USA', 'institution_ids': ['https://openalex.org/I28792581']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004096905', 'display_name': 'Felix Hagelskamp', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Felix Hagelskamp', 'raw_affiliation_strings': ['Department of Chemistry, Ludwig Maximilians Universität München, Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Ludwig Maximilians Universität München, Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080416368', 'display_name': 'Stefanie Kellner', 'orcid': 'https://orcid.org/0000-0003-3224-7502'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Stefanie M. Kellner', 'raw_affiliation_strings': ['Department of Chemistry, Ludwig Maximilians Universität München, Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Ludwig Maximilians Universität München, Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084054094', 'display_name': 'Fowzan S. Alkuraya', 'orcid': 'https://orcid.org/0000-0003-4158-341X'}, 'institutions': [{'id': 'https://openalex.org/I2800965796', 'display_name': 'King Faisal Specialist Hospital & Research Centre', 'ror': 'https://ror.org/05n0wgt02', 'country_code': 'SA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800965796']}, {'id': 'https://openalex.org/I134359838', 'display_name': 'Alfaisal University', 'ror': 'https://ror.org/00cdrtq48', 'country_code': 'SA', 'type': 'education', 'lineage': ['https://openalex.org/I134359838']}], 'countries': ['SA'], 'is_corresponding': False, 'raw_author_name': 'Fowzan S. Alkuraya', 'raw_affiliation_strings': ['Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia', 'Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia', 'institution_ids': ['https://openalex.org/I2800965796']}, {'raw_affiliation_string': 'Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia', 'institution_ids': ['https://openalex.org/I134359838']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011365621', 'display_name': 'Eric M. Phizicky', 'orcid': 'https://orcid.org/0000-0002-5095-6583'}, 'institutions': [{'id': 'https://openalex.org/I28792581', 'display_name': 'University of Rochester Medical Center', 'ror': 'https://ror.org/00trqv719', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I28792581', 'https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric M. Phizicky', 'raw_affiliation_strings': ['Center for RNA Biology, University of Rochester and University of Rochester Medical Center, Rochester, New York, USA', 'Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for RNA Biology, University of Rochester and University of Rochester Medical Center, Rochester, New York, USA', 'institution_ids': ['https://openalex.org/I28792581']}, {'raw_affiliation_string': 'Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York, USA', 'institution_ids': ['https://openalex.org/I28792581']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049959557', 'display_name': 'Dragony Fu', 'orcid': 'https://orcid.org/0000-0002-8725-8658'}, 'institutions': [{'id': 'https://openalex.org/I28792581', 'display_name': 'University of Rochester Medical Center', 'ror': 'https://ror.org/00trqv719', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I28792581', 'https://openalex.org/I5388228']}, {'id': 'https://openalex.org/I5388228', 'display_name': 'University of Rochester', 'ror': 'https://ror.org/022kthw22', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I5388228']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Dragony Fu', 'raw_affiliation_strings': ['Center for RNA Biology, University of Rochester and University of Rochester Medical Center, Rochester, New York, USA', 'Department of Biology, University of Rochester, Rochester, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Center for RNA Biology, University of Rochester and University of Rochester Medical Center, Rochester, New York, USA', 'institution_ids': ['https://openalex.org/I28792581']}, {'raw_affiliation_string': 'Department of Biology, University of Rochester, Rochester, New York, USA', 'institution_ids': ['https://openalex.org/I5388228']}]}], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5049959557'], 'corresponding_institution_ids': ['https://openalex.org/I28792581', 'https://openalex.org/I5388228'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.619, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '39', 'issue': '19', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12610', 'display_name': 'Functions and Regulation of RNA Editing by ADARs', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/wobble-base-pair', 'display_name': 'Wobble base pair', 'score': 0.79661095}, {'id': 'https://openalex.org/keywords/inosine', 'display_name': 'Inosine', 'score': 0.67185354}, {'id': 'https://openalex.org/keywords/speed-wobble', 'display_name': 'Speed wobble', 'score': 0.6076534}, {'id': 'https://openalex.org/keywords/mrna-modification', 'display_name': 'mRNA modification', 'score': 0.532961}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8292241}, {'id': 'https://openalex.org/C203353237', 'wikidata': 'https://www.wikidata.org/wiki/Q2141556', 'display_name': 'Wobble base pair', 'level': 5, 'score': 0.79661095}, {'id': 'https://openalex.org/C2777610669', 'wikidata': 'https://www.wikidata.org/wiki/Q422564', 'display_name': 'Inosine', 'level': 3, 'score': 0.67185354}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.62565815}, {'id': 'https://openalex.org/C50566430', 'wikidata': 'https://www.wikidata.org/wiki/Q1817859', 'display_name': 'Speed wobble', 'level': 2, 'score': 0.6076534}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.5462836}, {'id': 'https://openalex.org/C153957851', 'wikidata': 'https://www.wikidata.org/wiki/Q201448', 'display_name': 'Transfer RNA', 'level': 4, 'score': 0.52710474}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.43121552}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.37151065}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32616538}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.2964014}, {'id': 'https://openalex.org/C2776991684', 'wikidata': 'https://www.wikidata.org/wiki/Q190012', 'display_name': 'Adenosine', 'level': 2, 'score': 0.109081835}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.10562605}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C74650414', 'wikidata': 'https://www.wikidata.org/wiki/Q11397', 'display_name': 'Classical mechanics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000243', 'descriptor_name': 'Adenosine Deaminase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008607', 'descriptor_name': 'Intellectual Disability', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012345', 'descriptor_name': 'RNA, Transfer, Amino Acid-Specific', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000243', 'descriptor_name': 'Adenosine Deaminase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000243', 'descriptor_name': 'Adenosine Deaminase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000243', 'descriptor_name': 'Adenosine Deaminase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007288', 'descriptor_name': 'Inosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007288', 'descriptor_name': 'Inosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008607', 'descriptor_name': 'Intellectual Disability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010375', 'descriptor_name': 'Pedigree', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012345', 'descriptor_name': 'RNA, Transfer, Amino Acid-Specific', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.00203-19', 'pdf_url': 'https://mcb.asm.org/content/mcb/39/19/e00203-19.full.pdf', 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6751630', 'pdf_url': 'https://europepmc.org/articles/pmc6751630?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751630', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/277079', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2018/03/07/277079.full.pdf', 'source': None, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31263000', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.00203-19', 'pdf_url': 'https://mcb.asm.org/content/mcb/39/19/e00203-19.full.pdf', 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320306076', 'funder_display_name': 'National Science Foundation', 'award_id': '1552126'}, {'funder': 'https://openalex.org/F4320322997', 'funder_display_name': 'King Abdulaziz City for Science and Technology', 'award_id': '08-MED497-20'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'GM052347'}], 'datasets': [], 'versions': [], 'referenced_works_count': 77, 'referenced_works': ['https://openalex.org/W1143895086', 'https://openalex.org/W1539000680', 'https://openalex.org/W1566729113', 'https://openalex.org/W1890243244', 'https://openalex.org/W1898085476', 'https://openalex.org/W1906138272', 'https://openalex.org/W1935366897', 'https://openalex.org/W1965531591', 'https://openalex.org/W1967163463', 'https://openalex.org/W1974649194', 'https://openalex.org/W1981264193', 'https://openalex.org/W1982721051', 'https://openalex.org/W1986851354', 'https://openalex.org/W1988335222', 'https://openalex.org/W1988411751', 'https://openalex.org/W1996351611', 'https://openalex.org/W1996446847', 'https://openalex.org/W2004892117', 'https://openalex.org/W2006178602', 'https://openalex.org/W2009427029', 'https://openalex.org/W2013532225', 'https://openalex.org/W2034076823', 'https://openalex.org/W2034869545', 'https://openalex.org/W2038379310', 'https://openalex.org/W2038989483', 'https://openalex.org/W2045537814', 'https://openalex.org/W2051210276', 'https://openalex.org/W2052885644', 'https://openalex.org/W2062237715', 'https://openalex.org/W2062973054', 'https://openalex.org/W2065504621', 'https://openalex.org/W2068119233', 'https://openalex.org/W2072926131', 'https://openalex.org/W2073104221', 'https://openalex.org/W2073655863', 'https://openalex.org/W2074731176', 'https://openalex.org/W2075839436', 'https://openalex.org/W2076772609', 'https://openalex.org/W2082617758', 'https://openalex.org/W2090712859', 'https://openalex.org/W2094617711', 'https://openalex.org/W2097843864', 'https://openalex.org/W2097884184', 'https://openalex.org/W2106845910', 'https://openalex.org/W2113021729', 'https://openalex.org/W2114942495', 'https://openalex.org/W2116976668', 'https://openalex.org/W2129334819', 'https://openalex.org/W2133373723', 'https://openalex.org/W2138196920', 'https://openalex.org/W2143801120', 'https://openalex.org/W2150038630', 'https://openalex.org/W2159556459', 'https://openalex.org/W2159616946', 'https://openalex.org/W2167279371', 'https://openalex.org/W2219462594', 'https://openalex.org/W2256682960', 'https://openalex.org/W2264471836', 'https://openalex.org/W2319304516', 'https://openalex.org/W2342484046', 'https://openalex.org/W2342587579', 'https://openalex.org/W2486604077', 'https://openalex.org/W2524107473', 'https://openalex.org/W2559362258', 'https://openalex.org/W2612048558', 'https://openalex.org/W2623887734', 'https://openalex.org/W2742420066', 'https://openalex.org/W2752393783', 'https://openalex.org/W2753618916', 'https://openalex.org/W2754553258', 'https://openalex.org/W2755027239', 'https://openalex.org/W2768762471', 'https://openalex.org/W2793949051', 'https://openalex.org/W2846768057', 'https://openalex.org/W2895380605', 'https://openalex.org/W2904341515', 'https://openalex.org/W2911368831'], 'related_works': ['https://openalex.org/W2496843778', 'https://openalex.org/W2167718303', 'https://openalex.org/W2137497252', 'https://openalex.org/W2068694787', 'https://openalex.org/W2067263867', 'https://openalex.org/W2063867253', 'https://openalex.org/W2013903274', 'https://openalex.org/W2001750244', 'https://openalex.org/W1975586269', 'https://openalex.org/W1968157568'], 'abstract_inverted_index': {'The': [0], 'formation': [1, 157], 'of': [2, 8, 38, 60, 93, 147, 158], 'inosine': [3, 82, 151], 'at': [4], 'the': [5, 17, 34, 47, 55, 61, 89, 110], 'wobble': [6, 81, 150], 'position': [7], 'eukaryotic': [9], 'tRNAs': [10], 'is': [11, 33, 49, 163], 'an': [12, 121, 159], 'essential': [13], 'modification': [14, 152], 'catalyzed': [15], 'by': [16, 135], 'ADAT2/ADAT3': [18], 'complex.': [19], 'In': [20], 'humans,': [21], 'a': [22, 97, 141], 'valine-to-methionine': [23], 'mutation': [24, 48, 63], '(V144M)': [25], 'in': [26, 44, 83, 100, 116, 149], 'ADAT3': [27, 148], 'that': [28, 69, 131, 155], 'originated': [29], '∼1,600': [30], 'years': [31], 'ago': [32], 'most': [35], 'common': [36], 'cause': [37], 'autosomal': [39], 'recessive': [40], 'intellectual': [41], 'disability': [42], '(ID)': [43], 'Arabia.': [45], 'While': [46, 104], 'predicted': [50], 'to': [51, 124], 'affect': [52], 'protein': [53], 'structure,': [54], 'molecular': [56], 'and': [57, 153], 'cellular': [58], 'effects': [59], 'V144M': [62], 'are': [64], 'unknown.': [65], 'Here,': [66], 'we': [67], 'show': [68], 'cell': [70, 91], 'lines': [71, 92], 'derived': [72], 'from': [73, 88], 'ID-affected': [74, 94], 'individuals': [75, 95], 'expressing': [76], 'only': [77], 'ADAT3-V144M': [78, 105, 119], 'exhibit': [79, 114], 'decreased': [80], 'certain': [84], 'tRNAs.': [85], 'Moreover,': [86], 'extracts': [87], 'same': [90], 'display': [96], 'severe': [98], 'reduction': [99], 'tRNA': [101], 'deaminase': [102], 'activity.': [103, 117], 'maintains': [106], 'interactions': [107], 'with': [108, 128], 'ADAT2,': [109], 'purified': [111], 'ADAT2/3-V144M': [112], 'complexes': [113], 'defects': [115], 'Notably,': [118], 'exhibits': [120], 'increased': [122], 'propensity': [123], 'form': [125], 'aggregates': [126], 'associated': [127], 'cytoplasmic': [129], 'chaperonins': [130], 'can': [132], 'be': [133], 'suppressed': [134], 'ADAT2': [136], 'overexpression.': [137], 'These': [138], 'results': [139], 'identify': [140], 'key': [142], 'role': [143], 'for': [144, 165], 'ADAT2-dependent': [145], 'folding': [146], 'indicate': [154], 'proper': [156, 166], 'active': [160], 'ADAT2/3': [161], 'complex': [162], 'crucial': [164], 'neurodevelopment.': [167]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2953584706', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-09-11T23:34:58.320498', 'created_date': '2019-07-12'}