Title: Direct introduction of CH2OH by intermolecular trapping of CO
Abstract: Alkyl iodides are converted to the corresponding hydroxymethyl compounds in good yield by treatment with catalytic triphenylgermane-NaBH3CN-AIBN in benzene-THF under an atmosphhere of CO at high pressure. This methodology is used for the synthesis of an analogue of the B ring of the calicheamicin oligoccharide in which the hydroxylamine at C4 is replaced by a hydroxymethyl group.
Publication Year: 1993
Publication Date: 1993-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 40
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