Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2953161358', 'doi': 'https://doi.org/10.1101/552745', 'title': 'Visualizing Conformation Transitions of the Lipid Flippase MurJ', 'display_name': 'Visualizing Conformation Transitions of the Lipid Flippase MurJ', 'publication_year': 2019, 'publication_date': '2019-02-18', 'ids': {'openalex': 'https://openalex.org/W2953161358', 'doi': 'https://doi.org/10.1101/552745', 'mag': '2953161358'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/552745', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2019/02/19/552745.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2019/02/19/552745.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005884186', 'display_name': 'Alvin C. Y. Kuk', 'orcid': 'https://orcid.org/0000-0002-4122-0259'}, 'institutions': [{'id': 'https://openalex.org/I170897317', 'display_name': 'Duke University', 'ror': 'https://ror.org/00py81415', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170897317']}, {'id': 'https://openalex.org/I4210153043', 'display_name': 'Duke University Hospital', 'ror': 'https://ror.org/04bct7p84', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876', 'https://openalex.org/I4210153043']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alvin C. Y. Kuk', 'raw_affiliation_strings': ['Department of Biochemistry, Duke University Medical Center, 303 Research Drive, Durham, North Carolina 2770, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Duke University Medical Center, 303 Research Drive, Durham, North Carolina 2770, USA', 'institution_ids': ['https://openalex.org/I170897317', 'https://openalex.org/I4210153043', 'https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104106143', 'display_name': 'Aili Hao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170897317', 'display_name': 'Duke University', 'ror': 'https://ror.org/00py81415', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170897317']}, {'id': 'https://openalex.org/I4210153043', 'display_name': 'Duke University Hospital', 'ror': 'https://ror.org/04bct7p84', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876', 'https://openalex.org/I4210153043']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Aili Hao', 'raw_affiliation_strings': ['Department of Biochemistry, Duke University Medical Center, 303 Research Drive, Durham, North Carolina 2770, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Duke University Medical Center, 303 Research Drive, Durham, North Carolina 2770, USA', 'institution_ids': ['https://openalex.org/I170897317', 'https://openalex.org/I4210153043', 'https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091566121', 'display_name': 'Ziqiang Guan', 'orcid': 'https://orcid.org/0000-0002-8082-3423'}, 'institutions': [{'id': 'https://openalex.org/I170897317', 'display_name': 'Duke University', 'ror': 'https://ror.org/00py81415', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170897317']}, {'id': 'https://openalex.org/I4210153043', 'display_name': 'Duke University Hospital', 'ror': 'https://ror.org/04bct7p84', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876', 'https://openalex.org/I4210153043']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ziqiang Guan', 'raw_affiliation_strings': ['Department of Biochemistry, Duke University Medical Center, 303 Research Drive, Durham, North Carolina 2770, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Duke University Medical Center, 303 Research Drive, Durham, North Carolina 2770, USA', 'institution_ids': ['https://openalex.org/I170897317', 'https://openalex.org/I4210153043', 'https://openalex.org/I4210126298']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101793427', 'display_name': 'Seok‐Yong Lee', 'orcid': 'https://orcid.org/0000-0002-0662-9921'}, 'institutions': [{'id': 'https://openalex.org/I170897317', 'display_name': 'Duke University', 'ror': 'https://ror.org/00py81415', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170897317']}, {'id': 'https://openalex.org/I4210153043', 'display_name': 'Duke University Hospital', 'ror': 'https://ror.org/04bct7p84', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876', 'https://openalex.org/I4210153043']}, {'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Seok-Yong Lee', 'raw_affiliation_strings': ['Department of Biochemistry, Duke University Medical Center, 303 Research Drive, Durham, North Carolina 2770, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Duke University Medical Center, 303 Research Drive, Durham, North Carolina 2770, USA', 'institution_ids': ['https://openalex.org/I170897317', 'https://openalex.org/I4210153043', 'https://openalex.org/I4210126298']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5101793427'], 'corresponding_institution_ids': ['https://openalex.org/I170897317', 'https://openalex.org/I4210153043', 'https://openalex.org/I4210126298'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10120', 'display_name': 'Bacterial Physiology and Genetics', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11048', 'display_name': 'Ecology and Evolution of Viruses in Ecosystems', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2303', 'display_name': 'Ecology'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lipid-ii', 'display_name': 'Lipid II', 'score': 0.95688623}, {'id': 'https://openalex.org/keywords/flippase', 'display_name': 'Flippase', 'score': 0.9537554}, {'id': 'https://openalex.org/keywords/secondary-structure-prediction', 'display_name': 'Secondary Structure Prediction', 'score': 0.443113}], 'concepts': [{'id': 'https://openalex.org/C2780183148', 'wikidata': 'https://www.wikidata.org/wiki/Q21099571', 'display_name': 'Lipid II', 'level': 4, 'score': 0.95688623}, {'id': 'https://openalex.org/C2777019660', 'wikidata': 'https://www.wikidata.org/wiki/Q106947147', 'display_name': 'Flippase', 'level': 5, 'score': 0.9537554}, {'id': 'https://openalex.org/C2776634448', 'wikidata': 'https://www.wikidata.org/wiki/Q206920', 'display_name': 'Peptidoglycan', 'level': 3, 'score': 0.7312854}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5797938}, {'id': 'https://openalex.org/C206212055', 'wikidata': 'https://www.wikidata.org/wiki/Q2553138', 'display_name': 'Glycan', 'level': 3, 'score': 0.5775144}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4809598}, {'id': 'https://openalex.org/C19655278', 'wikidata': 'https://www.wikidata.org/wiki/Q3293735', 'display_name': 'Bacterial cell structure', 'level': 3, 'score': 0.44182354}, {'id': 'https://openalex.org/C39944091', 'wikidata': 'https://www.wikidata.org/wiki/Q423279', 'display_name': 'Lipid bilayer', 'level': 3, 'score': 0.43702793}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.34936494}, {'id': 'https://openalex.org/C125235067', 'wikidata': 'https://www.wikidata.org/wiki/Q128700', 'display_name': 'Cell wall', 'level': 2, 'score': 0.3233048}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.2809698}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26076692}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.24091461}, {'id': 'https://openalex.org/C108625454', 'wikidata': 'https://www.wikidata.org/wiki/Q187126', 'display_name': 'Glycoprotein', 'level': 2, 'score': 0.12619025}, {'id': 'https://openalex.org/C2778918659', 'wikidata': 'https://www.wikidata.org/wiki/Q186915', 'display_name': 'Phospholipid', 'level': 3, 'score': 0.11189297}, {'id': 'https://openalex.org/C2779637612', 'wikidata': 'https://www.wikidata.org/wiki/Q2354337', 'display_name': 'Phosphatidylserine', 'level': 4, 'score': 0.09768847}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/552745', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2019/02/19/552745.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/552745', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2019/02/19/552745.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1189912934', 'https://openalex.org/W1911934392', 'https://openalex.org/W1974920434', 'https://openalex.org/W1977272323', 'https://openalex.org/W1981303221', 'https://openalex.org/W2019198879', 'https://openalex.org/W2027408247', 'https://openalex.org/W2028184433', 'https://openalex.org/W2029667189', 'https://openalex.org/W2035586500', 'https://openalex.org/W2041791898', 'https://openalex.org/W2043615331', 'https://openalex.org/W2047399603', 'https://openalex.org/W2053970377', 'https://openalex.org/W2067174909', 'https://openalex.org/W2067800798', 'https://openalex.org/W2068442884', 'https://openalex.org/W2073032357', 'https://openalex.org/W2083190097', 'https://openalex.org/W2094664062', 'https://openalex.org/W2095402347', 'https://openalex.org/W2105668062', 'https://openalex.org/W2107312456', 'https://openalex.org/W2108713843', 'https://openalex.org/W2110808180', 'https://openalex.org/W2112562361', 'https://openalex.org/W2118212514', 'https://openalex.org/W2122994276', 'https://openalex.org/W2124026197', 'https://openalex.org/W2134967712', 'https://openalex.org/W2136909852', 'https://openalex.org/W2140295865', 'https://openalex.org/W2141861996', 'https://openalex.org/W2142270194', 'https://openalex.org/W2150981663', 'https://openalex.org/W2152311269', 'https://openalex.org/W2153781183', 'https://openalex.org/W2154197653', 'https://openalex.org/W2157728632', 'https://openalex.org/W2163341755', 'https://openalex.org/W2165565773', 'https://openalex.org/W2234306941', 'https://openalex.org/W2301186499', 'https://openalex.org/W2336704559', 'https://openalex.org/W2533385232', 'https://openalex.org/W255996521', 'https://openalex.org/W2565680183', 'https://openalex.org/W2589875042', 'https://openalex.org/W2606552363', 'https://openalex.org/W2618803170', 'https://openalex.org/W2749383241', 'https://openalex.org/W2752211880', 'https://openalex.org/W2770618149', 'https://openalex.org/W2782885942', 'https://openalex.org/W2788938150', 'https://openalex.org/W2790556376', 'https://openalex.org/W2791476169', 'https://openalex.org/W2793083001', 'https://openalex.org/W2808539404', 'https://openalex.org/W2809234913', 'https://openalex.org/W2951041301', 'https://openalex.org/W4248872320'], 'related_works': ['https://openalex.org/W4253814562', 'https://openalex.org/W4244806462', 'https://openalex.org/W4229571829', 'https://openalex.org/W3152034531', 'https://openalex.org/W2806087678', 'https://openalex.org/W2095402347', 'https://openalex.org/W2083344288', 'https://openalex.org/W2045404157', 'https://openalex.org/W2009001568', 'https://openalex.org/W1003743096'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'biosynthesis': [2], 'of': [3, 15, 48, 56, 68, 76, 119], 'many': [4], 'polysaccharides,': [5], 'including': [6, 58], 'bacterial': [7, 41], 'peptidoglycan': [8, 33], 'and': [9, 45, 83, 92, 112], 'eukaryotic': [10], 'N-linked': [11], 'glycans,': [12], 'requires': [13], 'transport': [14], 'lipid-linked': [16, 32], 'oligosaccharide': [17], '(LLO)': [18], 'precursors': [19], 'across': [20], 'the': [21, 28, 31, 53, 97, 107, 117], 'membrane': [22], 'by': [23], 'specialized': [24], 'flippases.': [25], 'MurJ': [26, 77, 101], 'is': [27], 'flippase': [29], 'for': [30, 110, 116], 'precursor': [34], 'Lipid': [35, 59], 'II,': [36], 'a': [37, 46, 66, 114], 'key': [38, 108], 'player': [39], 'in': [40, 79, 100], 'cell': [42], 'wall': [43], 'synthesis,': [44], 'target': [47], 'recently': [49], 'discovered': [50], 'antibacterials.': [51], 'However,': [52], 'flipping': [54], 'mechanism': [55], 'LLOs': [57], 'II': [60], 'remains': [61], 'poorly': [62], 'understood': [63], 'due': [64], 'to': [65], 'dearth': [67], 'structural': [69], 'information.': [70], 'Here': [71], 'we': [72, 95], 'report': [73], 'crystal': [74], 'structures': [75], 'captured': [78], 'inward-closed,': [80], 'inward-open,': [81], 'inward-occluded': [82], 'outward-facing': [84], 'conformations.': [85], 'Together': [86], 'with': [87], 'cysteine': [88], 'accessibility,': [89], 'mass': [90], 'spectrometry,': [91], 'complementation': [93], 'studies,': [94], 'elucidate': [96], 'conformational': [98], 'transitions': [99], 'that': [102], 'mediate': [103], 'lipid': [104], 'flipping,': [105], 'identified': [106], 'ion': [109], 'function,': [111], 'provide': [113], 'framework': [115], 'development': [118], 'inhibitors.': [120]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2953161358', 'counts_by_year': [{'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-09-14T15:22:52.273272', 'created_date': '2019-06-27'}