Dynamic expression of tRNA‐derived small RNAs define cellular states

Name: Work Video:
Duration: 3 min 30 s
Srikar Krishna; Daniel Yim; Vairavan Lakshmanan; Varsha Tirumalai; Judice L.Y. Koh; Jung Eun Park; Jit Kong Cheong; Joo-Leng Low; Michelle Gek Liang Lim; Siu Kwan Sze; P. V. Shivaprasad; Akash Gulyani; S. Raghavan; Dasaradhi Palakodeti; Ramanuj DasGupta
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'Information': [818], 'Krishna1,2,3,‡,': [820], 'Yim4,‡,': [823], 'Lakshmanan2,3,‡,': [825], 'Tirumalai3,5,': [827], 'Koh4,': [830], 'Park6,': [833], 'Cheong7,': [836], 'Low4,': [839], 'Lim4,': [842], 'Sze6,': [845], 'Shivaprasad5,': [847], 'Gulyani2,': [849], '*,1,': [852], '*,2': [855], '*,4': [859], '1Centre': [860], '2Technologies': [876], '3SASTRA': [892], '4Precision': [897], '5National': [906], '6School': [913], '7Program': [923], '‡These': [936], 'authors': [937], 'are': [938, 1199, 1237, 1407, 1489, 1564, 1616, 1983, 2026, 2151, 2307, 2597, 2843, 3614, 3847, 4035], 'contributed': [939], 'equally': [940], 'to': [941, 1016, 1019, 1046, 1336, 1379, 1568, 1632, 1702, 1860, 1892, 1896, 1901, 1948, 1965, 1996, 2041, 2131, 2137, 2139, 2185, 2209, 2274, 2287, 2363, 2472, 2534, 2639, 2824, 2859, 2899, 3165, 3324, 3354, 3372, 3414, 3590, 3623, 3695, 3722, 4027, 4037, 4076, 4113], 'work': [943], '‡[Correction': [944], 'added': [945, 4123], 'on': [946, 1397, 1671, 2316, 2680, 3009, 3738, 3749], '20': [947], '2019,': [949], 'after': [950, 2941, 2977], 'first': [951], 'online': [952], 'publication:': [953], "authors'": [955], 'affiliations': [956], 'have': [957, 1035, 1047, 1326, 1440, 1556, 1595, 1629, 1729, 2020, 2090, 3908], 'been': [958, 1441, 1577, 1630], 'corrected.]': [959], '*Corresponding': [960, 969, 978], 'author.': [961, 970, 979], 'Tel:': [962, 971, 980], '+91': [963, 972], '80': [964, 973], '23666743;': [965], 'E-mail:': [966, 975, 984], '23666767;': [974], '+65': [981], '6808': [982], '8005;': [983], 'EMBO': [987], 'Reports': [988], '(2019)20:e47789https://doi.org/10.15252/embr.201947789': [989], 'PDFDownload': [990], 'PDF': [991], 'article': [993], 'text': [994], 'main': [996], 'figures.': [997], 'Peer': [998], 'ReviewDownload': [999], 'a': [1000, 1087, 1097, 1119, 1168, 1282, 1346, 1383, 1597, 1659, 1758, 1836, 1851, 1981, 1998, 2021, 2037, 2058, 2110, 2177, 2668, 2681, 2759, 2794, 2805, 2838, 2948, 2971, 3028, 3040, 3320, 3355, 3399, 3573, 3591, 3663, 3681, 3688, 3827, 3896, 3910, 3948, 4002, 4019, 4030, 4099, 4137], 'summary': [1001], 'editorial': [1004, 1008], 'decision': [1005, 1009], 'including': [1007, 1814], 'letters,': [1010], 'reviewer': [1011], 'comments': [1012], 'responses': [1015], 'feedback.': [1017], 'ToolsAdd': [1018], 'favoritesDownload': [1020], 'CitationsTrack': [1021], 'CitationsPermissions': [1022], 'ShareFacebookTwitterLinked': [1023], 'InMendeleyWechatReddit': [1024], 'Figures': [1025], '&': [1026], 'Info': [1027], 'Abstract': [1028], 'Transfer': [1029, 1195], 'RNA': [1030, 1251, 1392, 1451, 1537, 1711, 2127, 2156, 2270, 2283, 2323, 2418, 2521, 2573, 2678, 2889], '(tRNA)-derived': [1031, 1393], '(tsRNAs)': [1034], 'recently': [1036], 'emerged': [1037], 'as': [1038, 1358, 1497, 1544, 2309, 2385, 2629, 2667, 2725, 2793, 3319, 3609, 4184, 4186], 'important': [1039, 1200, 1305, 4026], 'regulators': [1040, 1201, 1545], 'protein': [1042, 1203, 1253, 1276, 3993, 4131], 'translation': [1043, 1160, 1226, 1605, 1699, 1708, 1751, 4071, 4087, 4116, 4132], 'shown': [1045, 1557, 1631], 'diverse': [1048], 'biological': [1049, 1375, 1465, 1494, 1831, 3143, 3918], 'functions.': [1050], 'However,': [1051, 1342], 'underlying': [1053, 1301], 'molecular': [1056, 1299, 3949], 'mechanisms': [1057, 1300, 4045], 'tsRNA': [1059, 2298, 2335, 2439, 2469, 2663, 3135, 3177, 3217, 3249, 3294, 3302, 3330, 3340, 3375, 3460, 3486, 3521, 3833, 3979, 4138, 4180, 4208], 'function': [1060, 1329, 1761, 1773, 2666, 3029, 3303, 3571, 3782], 'context': [1063], 'dynamic': [1065, 1284, 3125], 'cell-state': [1066, 1220, 1302, 1361, 2673], 'transitions': [1067, 1303], 'remain': [1068], 'unclear.': [1069], 'Expression': [1070, 2235], 'analysis': [1071, 2834, 3657, 3821], 'tsRNAs': [1073, 1208, 1236, 1245, 1258, 1531, 1919, 1930, 2085, 2222, 2486, 3085, 3189, 3423, 4063, 4227], 'distinct': [1075, 1191, 1516, 1837], 'heterologous': [1076, 1663, 1783, 2224, 2685], 'cell': [1077, 1132, 1177, 1192, 1665, 1766, 1784, 2225, 2340, 2344, 2452, 2580, 2701, 2746, 2769, 2820, 3273, 3285, 3671, 3843, 3932], 'tissue': [1079, 2227], 'models': [1080, 2228, 2686], 'stem': [1082, 1108, 1176, 1219, 2230, 2243, 2339, 2442, 2579, 2688, 2698, 2707, 2798, 2875, 3075, 3272, 3336, 3408, 3428, 3670, 3691, 3842, 4166], 'vs.': [1083, 2231, 2444, 2689, 2708, 2738, 2799, 3533], 'differentiated': [1084, 1150, 1247, 1796, 2232, 2445, 2690, 2768, 2800, 3430], 'revealed': [1086, 1118, 1596, 1725, 1835, 2835, 3641, 3995], 'differentiation-dependent': [1088], 'enrichment': [1089, 1655, 1917, 2664, 2761, 3665], '5′-tsRNAs.': [1091, 3050, 3129, 4124], 'We': [1092, 1134, 2878, 2895, 4144], 'report': [1093, 1653], 'identification': [1095], 'set': [1098, 1206, 1233, 3898, 4004, 4057], '5′-tsRNAs': [1100, 1117, 1138, 1173, 1188, 1540, 1602, 1628, 1657, 1672, 1691, 1728, 1763, 1791, 2010, 2101, 2146, 2203, 2695, 2764, 2808, 2817, 2856, 2908, 2940, 2969, 3005, 3025, 3067, 3232, 3270, 3282, 3391, 3630, 3719, 3748, 3893, 3928, 3945, 3958, 3999, 4016, 4049, 4194], 'that': [1101, 1136, 1292, 1485, 1558, 1579, 1690, 1726, 1738, 1787, 1915, 1967, 1973, 2035, 2069, 2272, 2285, 2785, 2836, 3022, 3038, 3613, 3668, 3683, 3714, 3846, 3927, 3936, 3942, 3996, 4014, 4029, 4062, 4193], 'is': [1102, 1209, 1281, 1304, 1314, 1482, 1526, 1792, 1963, 2070, 4025], 'upregulated': [1103, 1210, 1238, 3509, 3543, 3625, 3660, 3697, 3825, 3848], 'differentiating': [1105, 1878, 1885, 2163, 2245, 2328, 2525, 2700, 3310, 3632, 3817, 3829, 4168], 'mouse': [1106, 2536, 2546], 'embryonic': [1107], 'cells': [1109, 2164, 2329, 2711, 2717, 2741, 3076, 3686], '(mESCs).': [1110], 'Notably,': [1111, 1928], 'interactome': [1112, 3994, 4209], 'studies': [1113, 1325, 1594, 1688, 1715, 2828, 3290, 3907], 'with': [1114, 1124, 1142, 1250, 1259, 1265, 1634, 1716, 1743, 1799, 1922, 2165, 2331, 2373, 2378, 2389, 2398, 2409, 2772, 2930, 3304, 3520, 3524, 3783, 3895, 3944, 4001, 4047, 4066, 4151, 4181, 4213], 'differentially': [1115], 'enriched': [1116, 1673, 1794, 1847], 'switch': [1120], 'their': [1122, 1218, 1624, 1703, 3952], 'association': [1123, 1153, 4178], '"effector"': [1125], 'RNPs': [1126], '"target"': [1128], 'mRNAs': [1129, 1776, 3941], 'different': [1131, 1415, 1448, 1812, 2571, 2720, 3072, 3978, 4226], 'states.': [1133, 1193, 1666, 2581, 2691, 2801], 'demonstrate': [1135], 'specific': [1137, 1294, 1958, 2839, 3897, 4038], 'can': [1139, 1174, 1410, 1586, 1692, 2014, 2791], 'preferentially': [1140], 'interact': [1141, 1249, 1633, 3894, 3943, 4065], 'RNA-binding': [1144, 1636], 'protein,': [1145], 'Igf2bp1,': [1146], 'RA-induced': [1149, 2162, 2327, 2524, 3121, 3262, 3309, 3585, 3739, 3776], 'state.': [1151], 'This': [1152], 'influences': [1154], 'transcript': [1156, 1223, 1273, 1748, 3661], 'stability': [1157, 1224, 1749], 'thereby': [1159, 3729], 'pluripotency-promoting': [1163], 'factor,': [1164], 'c-Myc,': [1165], 'thus': [1166], 'providing': [1167], 'mechanistic': [1169], 'basis': [1170, 3950], 'how': [1172], 'modulate': [1175, 1693, 3271], 'mESCs.': [1180, 1680, 1927, 3755], 'Together': [1181], 'our': [1182, 1668, 1755, 2149, 2782, 2826, 3699, 3711, 3925], 'study': [1183, 1669, 3325], 'highlights': [1184], 'role': [1186, 1353, 1598, 1706, 3401, 3717, 3912, 4082], 'defining': [1190, 1765, 2819, 3284], 'Synopsis': [1194], 'RNA-derived': [1196], 'translation.': [1204, 4200], 'A': [1205, 1232], 'during': [1211, 1674, 1848, 2809, 3056, 3584, 3903], 'induced': [1212, 1241], 'differentiation': [1213, 1280, 1340, 1364, 1678, 1695, 2811, 3058, 3123, 3198, 3740, 3777, 3905], 'mESCs': [1215, 1248, 1809, 1886, 2240, 2526, 2913, 2933, 3122, 3184, 3276, 3433, 3742, 3778, 3830, 4163, 4211], 'regulates': [1217, 1745], 'modulating': [1222, 1333], 'pluripotency': [1229, 1338, 2237, 3274, 3323, 3672], 'factor': [1230], 'c-Myc.': [1231, 1266, 1753], '5′': [1235, 1244, 1257, 1534], 'upon': [1239, 3626, 3849, 4133], 'RA': [1240, 2978, 2989, 3182, 3193, 3237, 3535, 3548, 3966, 4216], 'mESC': [1242, 1694, 2810, 2831, 3057, 3904], 'differentiation.': [1243, 1311, 1849, 3238, 3263, 3731], 'binding': [1252], 'Igf2bp1.': [1254], 'Interaction': [1255], 'Igf2bp1': [1260], 'abrogates': [1261], "latter's": [1263], 'interaction': [1264, 1714, 1742, 4148], 'mRNA,': [1267], 'resulting': [1268], 'destabilization': [1270], 'c-Myc': [1272, 3612], 'reduced': [1275, 2935], 'expression.': [1277], 'Introduction': [1278], 'highly': [1283, 1521, 2046], 'involving': [1286], 'spatio-temporal': [1288], 'proteins': [1291, 1637, 3900, 3939, 4007, 4034, 4060, 4068, 4224], 'control': [1293, 1513], 'phenotypes.': [1296], 'Elucidating': [1297], 'understanding': [1307, 1472], 'Gene': [1312], 'tightly': [1315], 'regulated': [1316], 'at': [1317, 2114, 2204, 2719, 2914, 2954, 2974, 2985, 3116, 3194, 3962, 3986], 'transcriptional,': [1319], 'post-transcriptional,': [1320], 'translational': [1322, 1618], 'levels.': [1323], 'Multiple': [1324], 'identified': [1327, 1543, 2487, 2694], 'miRNAs': [1331, 1343], 'gene': [1334, 2003, 2078, 2294, 2301], 'drive': [1337], '1.': [1341, 2519], 'represent': [1344, 1868, 2252, 2364, 2428, 2557, 3095, 3148, 3157, 3204, 3447, 3471, 3496, 3761, 3790, 3859], 'only': [1345, 1980, 2175, 2837, 3039], 'subset': [1347], 'non-coding': [1349], '(ncRNAs).': [1351], 'The': [1352, 1454, 2549, 2646, 2855, 3092, 3145], 'other': [1355, 2195], 'ncRNAs': [1357], 'modulators': [1359], 'transition': [1362], 'has': [1365, 1377, 1467, 1575, 1647, 2036, 2057], 'remained': [1366, 1648], 'relatively': [1367, 2059], 'under-explored.': [1368], 'More': [1369], 'recently,': [1370], 'high-throughput': [1371], 'sequencing': [1372, 1804, 2550, 2679, 2886, 4156], 'various': [1374, 1569, 2477, 2774, 3064, 3117, 3258, 3540, 4197], 'samples': [1376, 2478, 3518], 'led': [1378, 3353, 3589], 'discovery': [1381], 'novel': [1384], 'species': [1385, 1452, 1525, 1560, 1842, 1858, 3065], 'called': [1389, 1533], 'transfer': [1391], 'RNAs.': [1395, 1480], 'Based': [1396], 'region': [1399], 'tRNA': [1401, 1971, 2002, 2077, 2187, 2293, 2300, 2314, 2474, 2547, 2593, 3012, 3230, 3242, 3256, 4084], 'from': [1402, 1933, 1939, 2158, 2268, 2348, 2449, 2491, 2696, 2703, 3137, 4159], 'which': [1403, 1894, 2056], 'these': [1404, 1409, 1460, 1477, 1486, 1559, 1600, 1855, 1889, 2100, 2140, 3128, 3403, 4015], 'processed,': [1408], 'be': [1411, 1976, 1997, 2015, 2121, 3047, 3624, 3696, 3721], 'classified': [1412], 'into': [1413, 1978, 2031, 2202, 2847, 3049], 'five': [1414, 2906], 'species:': [1416], '32–34': [1417], 'nt': [1418, 1423, 1841, 1857, 2417, 2542, 2589, 2620], '5′-': [1419, 1424], '3′-halves;': [1421], '18–22': [1422], '3′-tRNA': [1426], 'fragments': [1427, 2119, 4085], '(tRFs);': [1428], '3′U': [1430], 'tRFs': [1431], '2,': [1432, 2249, 3201, 3493], '3.': [1433, 3733], 'Endoribonucleases': [1434], 'RNase': [1435], 'Z,': [1436], 'Dicer,': [1437], 'angiogenin': [1439, 2095], 'implicated': [1442], 'processing': [1445, 1959, 1986, 2030, 2098, 2108, 2846], '4-6.': [1453], 'widespread': [1455], 'conserved': [1457, 1522], 'across': [1463, 2476, 2591, 2622, 2872, 3141, 3233, 3257], 'several': [1464, 1493, 1554, 1635, 3648], 'systems': [1466, 1785], 'piqued': [1468], 'interest': [1470], 'functional': [1474, 1642, 2827, 3289, 4205], 'significance': [1475, 2255, 2431, 2560, 3207, 3450, 3474, 3499, 3764, 3793, 3862], 'There': [1481], 'growing': [1483], 'evidence': [1484], 'involved': [1490, 3839, 4069], 'regulating': [1492, 1697, 1769, 3917], 'processes,': [1495], 'such': [1496, 1645, 3608], 'tumor': [1498], 'suppression': [1499], '7,': [1500, 1639, 3920], 'ribosomal': [1501], 'biogenesis': [1502], 'cancer': [1504, 2451, 2745], '8,': [1505], 'paternal': [1506], 'epigenetic': [1507], 'inheritance': [1508], '9,': [1509], '10,': [1510], 'LTR-retrotransposon': [1512], '11': [1514], 'through': [1515, 2885], 'mechanisms.': [1517], 'One': [1518], 'abundant': [1524], '5′-halves,': [1528], 'tiRNAs,': [1529], 'or': [1530, 1538, 1620, 2072, 2244, 2342, 3299, 3346, 4098, 4167, 4215], '(henceforth': [1532], '5′-tsRNA).': [1539], 'were': [1541, 1931, 2396, 2488, 3026, 3393, 3620, 3693], 'initially': [1542], 'Tetrahymena': [1547], 'stress': [1548, 1570], 'response': [1549, 1567, 3371], '5,': [1550, 2102], '6,': [1551, 1572, 1607, 2103, 4089], '12.': [1552], 'While': [1553, 2965], 'reports': [1555, 2089], 'produced': [1565], 'conditions': [1571, 1813, 1906, 2246, 3298, 3352, 3379, 3441, 3490, 3633, 4169], '13,': [1573], 'it': [1574, 1611], 'also': [1576, 3621], 'suggested': [1578, 2091, 4061], 'involvement': [1581, 2093, 2193], 'certain': [1583], 'hormonal': [1584], 'pathways': [1585, 3542], 'initiate': [1587], 'production': [1589], '5′-halves': [1591, 1935], '14.': [1592], 'Functional': [1593, 1681, 3420], 'angiogenin-cleaved': [1601], 'repressing': [1604], 'initiation': [1606, 1709], '15,': [1608, 1640, 3921, 4090], '16;': [1609], 'however,': [1610, 2106], 'remains': [1612], 'unclear': [1613], 'whether': [1614, 2144, 2659], 'they': [1615, 1867, 2726], 'global': [1617, 2795], 'repressors': [1619], 'exhibit': [1621, 4018], 'specificity': [1622], 'action.': [1625, 4023], 'Additionally,': [1626, 1991], 'while': [1627], '(RBPs)': [1638], 'consequence': [1643], 'interactions': [1646], 'largely': [1649, 4064], 'unexplored.': [1650], 'Here,': [1651], 'we': [1652, 1736, 2153, 2174, 2675, 2693, 2757, 2822, 3287, 3313, 3383, 3934, 3968, 4092, 4126, 4175], 'differential': [1654, 2882, 3031], 'broad': [1660], 'range': [1661], 'differentiation-associated': [1664], 'Specifically,': [1667, 1882, 2692], 'focuses': [1670], 'retinoic': [1675, 1826], 'acid': [1676, 1827], '(RA)-induced': [1677], 'characterization': [1682, 4206], 'using': [1683, 2258, 2434, 2563, 2829, 3210, 3453, 3477, 3502, 3572, 3767, 3796, 3852, 3865, 3976], 'antisense': [1684, 3305, 3576], 'oligo': [1685], '(ASO)-mediated': [1686], 'knockdown': [1687, 2392, 3737], 'suggests': [1689], 'active': [1698], 'addition': [1701, 4135], 'previously': [1704, 1759, 4080], 'reported': [1705, 4081], '15.': [1710], 'proteome': [1713], 'candidate': [1717, 2907, 3082, 3229], '5′-tsRNAs,': [1718, 1979, 4039], 'specifically': [1719, 2490], 'tsGlnCTG,': [1720, 1739, 3086, 3111, 3437, 3579], 'tsGluTTC,': [1721, 3088, 3112, 3344, 3582, 3983], 'tsGlyGCC,': [1722, 3087, 3110, 3580, 3982], 'tsValCAC,': [1724, 3089], 'individual': [1727, 2625, 4048, 4182], 'both': [1730, 1746], 'unique': [1731, 4044], 'overlapping': [1733], 'interactomes.': [1734], 'Mechanistically,': [1735], 'show': [1737], 'via': [1740], 'its': [1741, 2952], 'IGF2BP1,': [1744], 'Altogether,': [1754], 'data': [1756, 2783, 3701, 3712], 'implicate': [1757], 'unknown': [1760], 'tsRNA-interacting': [1775], 'proteins.': [1778], 'Results': [1779], 'Small': [1780, 2520], 'RNA-seq': [1781], 'reveals': [1786], 'consistently': [1793], 'compared': [1798, 2771, 3523], 'isogenic': [1800, 2776], 'stem-like': [1801, 2777, 3350], 'state': [1802, 1925, 3409], 'Deep': [1803], 'cultured': [1810, 4212], 'under': [1811, 3335, 3377, 3395, 3631, 4165], 'Wnt3a+LIF': [1815, 1904], '(leukemia': [1816], 'inhibitory': [1817], 'factor;': [1818], 'enhanced': [1819], 'pluripotency),': [1820, 1824], 'LIF': [1821, 1899, 3180, 3191, 3297, 3378, 3396, 3440, 3464, 3489, 3517, 4214], 'alone': [1822], '(baseline': [1823], '(RA;': [1828], 'differentiation)': [1829], 'replicates': [1832], '(Fig': [1833, 1880, 1907, 1952, 2011, 2086, 2188, 2712, 2729, 2750, 2754, 2779, 2867, 2891, 3333, 3361, 3380, 3410, 3597, 3650, 4008, 4050, 4072, 4140, 4170], 'EV1A)': [1834], 'population': [1838, 2324, 2840, 3042], '30–35': [1840, 1856, 2416, 2541, 2588, 2619], '(Figs': [1843, 1862, 1987, 2849, 2921, 2958, 2991, 3014, 3634, 3673, 3702], '1A': [1844], 'EV1B)': [1846], 'Intriguingly,': [1850], 'large': [1852], 'proportion': [1853, 4032], 'mapped': [1859, 1891, 2273, 2471, 2638], 'tRNAs': [1861, 1944, 2201, 2627, 2842, 2866, 3036, 3045, 3083], '1B': [1863, 1908], 'EV1C),': [1865], 'one': [1869], 'largest': [1872], 'pool': [1873, 3574], '1C).': [1881], 'RA-treated': [1884, 2612, 2912, 2932, 3754], '81.4%': [1887], 'reads': [1890, 2183, 2267, 2284, 2470, 2532, 2544, 2590, 2621, 2637], 'tRNAs,': [1893, 3097], 'dropped': [1895], '72%': [1897], '50.3%': [1902], 'culture': [1905], 'Dataset': [1910, 2870, 3653, 3707, 4011], 'EV1).': [1911], 'These': [1912, 2118], 'results': [1913], 'suggest': [1914, 2784, 3713], 'inversely': [1920], 'correlates': [1921], 'pluripotent': [1924], 'most': [1929, 2968], 'derived': [1932], '(hence': [1936], '5′-tsRNAs),': [1937], 'starting': [1938], 'nucleotide': [1940], '1–4': [1941], 'parent': [1943, 2473, 3011, 3255], 'terminating': [1946], 'prior': [1947], 'anticodon': [1950, 2306, 2651], 'loop': [1951], '1D,': [1953], 'D′': [1954], 'E),': [1956], 'suggesting': [1957, 2068, 2190, 3021, 3398, 4013, 4192], 'tRNAs.': [1961, 3158], 'It': [1962, 4024], 'intriguing': [1964], 'note': [1966, 4028], '468': [1970, 2624], 'loci': [1972], 'could': [1974, 2665], 'potentially': [1975], 'processed': [1977, 2489, 3048], 'few': [1982], 'selected': [1984, 2028, 2844], '1D′': [1988, 2850], 'EV1D).': [1990, 2012, 2087, 2854], 'there': [1992], 'did': [1993], 'not': [1994, 2027, 2050, 3007, 3027, 3887], 'seem': [1995], 'correlation': [1999, 2074], 'between': [2000, 2075, 2909, 3190, 4225], 'copy': [2004, 2023, 2038, 2061, 2079, 2295, 2302], 'number': [2005, 2039, 2062, 2080, 2296], 'abundance': [2008, 2065, 2083], 'As': [2013, 3954], 'seen': [2016], 'CysGCA': [2017], 'AlaAGC': [2019], 'high/comparable': [2022], 'number,': [2024], 'but': [2025], 'tsRNA.': [2032], 'Similarly,': [2033], 'MetCAT': [2034], 'comparable': [2040], 'GluTTC': [2042], '(one': [2043], 'represented': [2047, 2308], 'tsRNA)': [2048], 'does': [2049], 'produce': [2051], 'tsRNAs.': [2052, 3104], 'In': [2053, 2928, 4074], 'contrast,': [2054], 'GlyCCC': [2055], 'low': [2060], 'produces': [2063], 'high': [2064, 2786, 3961], 'tsRNAs,': [2067, 3152], 'little': [2071], 'no': [2073], 'Previous': [2088], '17,': [2104], '18;': [2105], 'yields': [2109], '2′,3′': [2111], 'cyclic': [2112], 'phosphate': [2113], '3′': [2116], 'end.': [2117], 'would': [2120, 3946], 'missed': [2122], 'conventional': [2125], 'library': [2128], 'preparation': [2129], 'due': [2130], 'inability': [2133], 'adapters': [2136], 'ligate': [2138], 'fragments.': [2141], 'To': [2142, 2657, 2812, 3277], 'ascertain': [2143], 'observed': [2147, 2176, 2884, 3384, 4127, 4176], 'system': [2150, 4112], 'angiogenin-dependent,': [2152], 'treated': [2154, 2330, 2397, 2408, 3183], 'isolated': [2157, 2347], '48': [2159, 2956, 2986, 3195, 3963], 'h': [2160, 2920, 2943, 2946, 2957, 2976, 2987, 3196, 3964], 'T4': [2166, 2332], 'polynucleotide': [2167], 'kinase': [2168], 'sequenced': [2170, 2479, 2575], 'libraries.': [2172], 'Interestingly,': [2173, 3677], 'modest': [2178, 3592], '15.3%': [2179], 'increase': [2180, 2950, 2973, 3593], 'mapping': [2184, 2533], 'EV1E),': [2189], 'possible': [2192], 'enzymes': [2196], 'cleavage': [2199], 'stage.': [2206], 'Click': [2207, 3163, 3412], 'here': [2208, 3164, 3413], 'expand': [2210, 3166, 3415], 'figure.': [2212, 3168, 3417], 'Figure': [2213, 2518, 3051, 3169, 3418, 3732, 4201], 'EV1.': [2214], 'Profiling': [2215], 'characterisation': [2217], 'A.': [2234, 2527, 3059, 3185, 4217], 'genes': [2238, 3667], 'grown': [2241, 4164], '(n': [2247, 2423, 3199, 3442, 3466, 3491, 3756, 3785, 3854], '=': [2248, 2424, 2603, 2606, 2611, 3200, 3443, 3467, 3492, 3757, 3786, 3855], 'error': [2250, 2426, 3202, 3445, 3469, 3494, 3759, 3788, 3857], 'bars': [2251, 2427, 2556, 3203, 3495, 3760, 3789, 3858], 'SD,': [2253, 2429, 3205, 3472], 'was': [2256, 2432, 2551, 2561, 3006, 3208, 3451, 3475, 3500, 3765, 3794, 3863, 3959], 'calculated': [2257, 2433, 2562, 3209, 3452, 3476, 3501, 3766, 3795, 3864], "Student's": [2259, 2435, 3211], 't-test).': [2260, 2436, 3212, 3455, 3479, 3504], 'B.': [2261, 2538, 3078, 3223], 'Size': [2262, 2278], 'distribution': [2263, 2279], 'sequence': [2266, 2585], 'libraries': [2271], 'genome.': [2276, 2318, 2537], 'C.': [2277, 2566, 3105, 3251], 'map': [2286, 2467, 2635], 'tRNA.': [2289, 2497], 'D.': [2290, 2582], 'Correlation': [2291], 'abundance.': [2299], 'numbers': [2303], 'every': [2305], 'percentages': [2310], 'total': [2313], 'copies': [2315], 'E.': [2319, 2632], 'Comparison': [2320], 'changes': [2325, 3386], 'PNK.': [2333], 'F.': [2334], 'profile': [2336], 'bulge': [2338], '(CD34+α6+)': [2341], 'basal': [2343], '(CD34−α6+)': [2345], 'populations': [2346, 2447, 2574, 2702], 'adult': [2349], 'murine': [2350, 2704], 'skin': [2351, 2705], '(see': [2352, 2459], 'Appendix': [2353, 2460], 'Fig': [2354, 3587], 'S1).': [2355], 'G.': [2356], 'Images': [2357], 'HMECs': [2359, 2371, 2377, 2394, 2421], '(Panels': [2360], 'I-IV)': [2361], 'engineered': [2362], 'stages': [2365, 2721, 4198], 'oncogenic': [2367, 2380, 2723], 'transformation:': [2368], 'I:': [2369], 'parental': [2370, 2592, 2626, 3035], 'immortalized': [2372, 2376], 'hTERT;': [2374], 'II:': [2375], 'tamoxifen-inducible': [2379], 'HRAS': [2381], '(hTERT/sT/HRASG12V:ER/EV);': [2382], 'III:': [2383], 'HMEC': [2384, 2406], 'described': [2386], 'II': [2388, 2407], 'additional': [2390], 'p53': [2391], '(hTERT/sT/HRASG12V:ER/shP53);': [2393], 'I-III': [2395], '130': [2399], 'nM': [2400], 'tamoxifen': [2401, 2410], '(5': [2402], 'days);': [2403], 'IV:': [2405], '(10': [2411], 'days).': [2412], 'G′.': [2413], 'Quantification': [2414], 'levels': [2419, 2787, 2903, 2936, 2966, 2983, 3003, 3013, 3023, 3376], 'I–IV': [2422], '3,': [2425, 3444, 3468], 'H,': [2437], 'I.': [2438], 'profiles': [2440], '(CD44+CD24−)': [2443], '(CD24+)': [2446], 'sorted': [2448, 2697], 'breast': [2450, 2744], 'lines:': [2453], 'MDA-MB-231': [2454, 2749], '(H)': [2455], 'HS578T': [2457, 2753], '(I)': [2458], 'Figs': [2461], 'S2': [2462], 'S3).': [2464], 'J.': [2465], 'Heat': [2466], 'residues': [2475], 'study.': [2482], 'Majority': [2483], '5′-half': [2493], 'mature': [2496], 'Data': [2498, 3550, 3868], 'information:': [2499, 3551, 3869], '*P': [2500, 3552, 3870], 'value': [2501, 2505, 2509, 3553, 3557, 3561, 3871, 3875, 3879, 3883], '<': [2502, 2506, 2510, 3554, 3558, 3562, 3872, 3876, 3880, 3884], '0.05,': [2503, 3555], '**P': [2504, 3874], '0.01;': [2507, 3877], '***P': [2508, 3556, 3878], '0.001;': [2511, 3881], 'n.s,': [2512], 'non-significant.': [2513], 'Download': [2514, 2516, 2653, 2655, 3159, 3161, 3264, 3266, 3564, 3566, 3889, 3891], 'figure': [2515, 2654, 3160, 3265, 3565, 3890], 'PowerPoint': [2517, 2656, 3162, 3267, 3567, 3892], 'profiling': [2522, 3640, 4161], 'Distribution': [2528], '25–35': [2530], 'mer': [2531], 'Proportion': [2539], 'genomic': [2543], 'matching': [2545], 'sequences.': [2548], 'done': [2552], 'duplicates.': [2554], 'Error': [2555], 'SEM,': [2558, 3448, 3497, 3762, 3791, 3860], 'unpaired': [2564, 3454, 3478, 3503, 3768, 3797, 3866], 't-test.': [2565, 3769, 3798, 3867], 'Pie': [2567, 3060], 'charts': [2568], 'depicting': [2569, 3062, 3804, 4220], 'three': [2578, 2874, 3071], 'Per': [2583, 2615], 'base': [2584, 2616], 'coverage': [2586, 2617], 'sequence.': [2594], 'Anticodon': [2595], 'positions': [2596], 'demarcated': [2598], 'discontinuous': [2600], 'lines': [2601, 3147, 3156], '(blue': [2602], 'LIF-treated,': [2604, 2609], 'gray': [2605], 'Wnt3': [2607], '+': [2608], 'red': [2610, 3100, 3246], 'mESCs).': [2613], 'D′.': [2614], 'plotted': [2628], 'heat': [2630, 2634], 'maps.': [2631], 'Positional': [2633], 'tRNAGlnCTG,': [2640], 'tRNAGluTTC,': [2641], 'tRNAValAAC,': [2642], 'tRNAGlyGCC': [2644], 'residues.': [2645], 'yellow': [2647], 'box': [2648], 'indicates': [2649], 'region.': [2652], 'investigate': [2658], 'phenomenon': [2661], 'general': [2669], 'read': [2670], 'out': [2671], 'transitions,': [2674], 'performed': [2676, 2896, 3288, 3314, 3969], 'variety': [2682], 'well-defined': [2684], '[CD34+α6+': [2706], 'CD34−α6+': [2709], 'non-stem': [2710], 'EV1F);': [2713], 'human': [2714], 'mammary': [2715], 'epithelial': [2716], '(HMECs)': [2718], 'transformation': [2724], 'gain': [2727], 'stemness': [2728, 3483, 3541, 3606, 3773], 'EV1G': [2730], 'G′)': [2732], '19,': [2733], '20;': [2734], 'CD44+CD24−': [2736], '(stem)': [2737], 'CD24+': [2739], '(non-stem)': [2740], 'two': [2743, 3142], 'lines,': [2747], 'namely': [2748], 'EV1H)': [2751], 'EV1I)].': [2755], 'Remarkably,': [2756], 'found': [2758, 3622, 3694], 'consistent': [2760], 'all': [2766, 2938], 'matched': [2775], 'EV1J).': [2780], 'Collectively,': [2781], '5′-tsRNA': [2789, 2848, 3570, 3736, 3781, 3850, 4150], 'serve': [2792], 'marker': [2796, 3484], 'group': [2806], 'understand': [2813, 3278], 'effect': [2815, 3280, 3327], 'states,': [2821, 3286, 3933], 'decided': [2823], 'focus': [2825], 'model.': [2832], 'Our': [2833], '2A,': [2852], 'predominantly': [2857], 'corresponded': [2858], 'GlnCTG,': [2860], 'GlyGCC,': [2861], 'GluTTC,': [2862], 'LysTTT,': [2863], 'ValCAC/AAC': [2865], '2A': [2868], 'EV2)': [2871], 'tested.': [2877, 3077], 'further': [2879, 4145], 'validated': [2880, 4146], 'enrichments': [2883], 'qPCR': [2890, 3174, 3186, 3434, 3835], 'EV2A': [2892], 'A′).': [2894], 'Northern': [2897, 3079, 3106, 3171, 3252, 3527], 'hybridization': [2898, 3139], 'compare': [2900], 'LIF-': [2910], '12,': [2915], '24,': [2916], '48,': [2917], '144': [2919, 2975], '2B,': [2922, 2959, 2992, 3015], 'C': [2923, 2960, 2993], 'C′,': [2925, 2962, 2995, 3016], 'EV2B).': [2927, 2964, 2997], 'comparison': [2929], 'LIF,': [2931], 'showed': [2934, 2970, 3662], 'tested': [2939, 3140], '12': [2942], '24': [2945], 'subsequent': [2949], '~': [2955], 'sharp': [2972], 'treatment,': [2979, 3967], 'tsGlnCTG': [2980, 3530], 'tsGluTTC': [2982], 'saturated': [2984], 'treatment': [2990], 'Importantly,': [2998], 'change': [3000], 'reflected': [3008], 'EV2B': [3018], 'C),': [3020], 'minor': [3041, 3400, 4031], 'may': [3046, 3720, 3930, 4017, 4195], '2.': [3052], 'Characterization': [3053], '5-tsRNAs': [3055], 'chart': [3061], 'expressed': [3068, 3269], 'blot': [3080, 3107, 3172, 3253, 3528], 'tsLysTTT.': [3091], 'black': [3093], 'arrows': [3094, 3101, 3240, 3247], 'mark': [3102], '5′-tsRNAs:': [3109], 'tsLysTTT,': [3113], 'tsValCAC': [3115], 'time': [3118, 3234, 3259, 3988], 'points': [3119, 3235, 3260], 'showing': [3124, 3215, 3507], 'C′.': [3130], 'Relative': [3131, 3480, 3770], 'quantification': [3132], 'bands': [3136], 'northern': [3138, 3226], 'replicates.': [3144], 'solid': [3146], 'dashed': [3155], 'EV2.': [3170], 'validation': [3175, 3187, 3836], 'A′.': [3213], 'Gel': [3214], 'band': [3218], 'amplified': [3219], 'qPCRs.': [3222], 'Replicate': [3224], 'blots': [3227], 'Black': [3239], 'indicate': [3241, 3248], 'species,': [3243], 'species.': [3250], 'Differentially': [3268], 'either': [3291], 'transfecting': [3293], 'mimics': [3295, 3341, 3392, 3522, 3980], 'blocking': [3301, 3569], 'oligos': [3306, 3577], '(ASOs)': [3307], 'conditions.': [3311, 3337, 3549], 'First,': [3312], 'alkaline': [3315, 3750], 'phosphatase': [3316, 3457, 3751], '(AP)': [3317], 'assays': [3318, 3458, 3971], 'measure': [3321, 4114], 'increased': [3329, 3374], 'mimic': [3331, 3461, 4139], 'EV3A)': [3334], 'Transfection': [3338], 'collectively': [3342], '(tsGlnCTG,': [3343, 3981], 'tsLysCTT/TTT)': [3345], 'individually': [3347], 'LIF-treated': [3349], 'growth': [3351], 'mild': [3356], 'decrease': [3357], 'AP': [3359, 3595], 'activity': [3360, 3596, 3752, 4117], 'EV3B).': [3362], 'Moreover,': [3363], 'none': [3364], 'stemness-related': [3367], 'markers': [3368, 3607, 3774], 'changed': [3369], 'EV3C).': [3381], 'Concurrently,': [3382], 'minimal': [3385], 'transcriptome': [3389, 3639, 3700, 3803], 'when': [3390], 'transfected': [3394, 3438, 3487, 3519], 'conditions,': [3397], 'EV3D).': [3411], 'EV3.': [3419], 'interrogation': [3421], 'modulation': [3426], 'quantitation': [3435], 'bar': [3446, 3470], 'Alkaline': [3456], 'overexpression': [3462], 'condition': [3465], 'Volcano': [3505, 3799], 'plot': [3506, 3800], 'transcripts': [3508, 3649, 3807, 3812, 3824, 3838, 3902], '(in': [3510, 3514, 3544, 3808, 3813], 'green)': [3511, 3545, 3809], 'downregulated': [3513, 3811], 'pink)': [3515, 3814], 'mock': [3525], 'controls.': [3526], 'RA-': [3532], 'ASO-transfected': [3534], 'cells.': [3536, 3818], 'F': [3537], 'Components': [3538], 'ASO-treated': [3547, 3816], '0.001,': [3559], '****P': [3560, 3882], '0.0001.': [3563], 'Conversely,': [3568], '(against': [3578], 'tsGlyCCC,': [3581], 'tsLysTTT': [3583], 'differentiation;': [3586], 'EV3E)': [3588], '3A).': [3598], 'Corroborating': [3599], 'initial': [3601], 'observation,': [3602], 'some': [3603], 'Klf4': [3610], 'downstream': [3615], 'JAK-STAT': [3618], 'pathway': [3619, 3656, 3820, 3845], 'ASO-mediated': [3627, 3745], 'inhibition': [3628, 3746, 4129], '3B': [3635], 'EV3F).': [3637, 3676], 'Whole': [3638], 'significant': [3642, 3664], 'alterations': [3643], '3C': [3651], 'EV3).': [3654, 3708], 'KEGG': [3655, 3819], 'regulate': [3669, 4196], '3D': [3674], 'Lif': [3678], 'Wnt3,': [3680], 'combination': [3682], 'drives': [3684], 'toward': [3687], 'homogeneous': [3690], 'state,': [3692], '3E': [3703], 'EV3F,': [3705], 'Taken': [3709], 'together,': [3710], 'primary': [3716], 'restrain': [3723], 'stemness-promoting': [3727], 'genes,': [3728], 'facilitating': [3730], 'Effect': [3734, 3743], '3),': [3758], 'blocked': [3779, 3831], 'ASOs.': [3784, 3853], '2),': [3787, 3856], 'overexpressed': [3806], 'RA-mediated': [3828], 'function.': [3834, 3953], 'signaling': [3844], 'knockdowns': [3851], '0.05;': [3873], '0.0001;': [3885], 'n.s.,': [3886], 'significant.': [3888], 'Recent': [3906], 'highlighted': [3909], 'crucial': [3911], 'tsRNA–protein': [3914], 'interactions,': [3915], 'processes': [3919], '21,': [3922], '22.': [3923], 'Given': [3924], 'observation': [3926], 'reasoned': [3935], 'characterizing': [3937], 'provide': [3947], 'synchronously': [3960], 'pulldown': [3970], 'followed': [3972], 'mass': [3974], 'spectrometry': [3975], 'four': [3977, 3998], 'tsValCCC)': [3985], 'point.': [3989], 'Analysis': [3990], 'interacted': [4000], 'common': [4003, 4056, 4222], '109': [4006], '4A': [4009], 'EV4),': [4012], 'similar': [4020], 'mode': [4021], 'exclusive': [4036], 'highlighting': [4040], 'possibility': [4042], 'associated': [4046], '4A).': [4051], 'GO': [4052], 'annotation': [4053], 'interacting': [4059, 4223], 'EV4A).': [4073], 'order': [4075], 'independently': [4077], 'validate': [4078], 'repression': [4088], '16,': [4091], 'used': [4093], 'an': [4094, 4104, 4128], 'uncapped': [4095], 'luciferase': [4096], 'mRNA': [4097, 4102], 'capped': [4100], 'GFP': [4101], 'vitro': [4106], 'biochemically': [4107], 'defined,': [4108], 'rabbit': [4109], 'reticulocyte': [4110], 'lysate': [4111], 'presence': [4120], 'exogenously': [4122], 'Indeed,': [4125], 'EV4B': [4141], 'B′).': [4143], 'translating': [4153], 'units': [4154], 'fractions': [4157], 'obtained': [4158], 'polysome': [4160, 4190], 'EV4C': [4171], 'C′).': [4173], 'Surprisingly,': [4174], 'subunits': [4183], 'well': [4185], 'monosome': [4188], 'complexes,': [4191], '4.': [4202], 'Identification': [4203], 'Venn': [4218], 'diagram': [4219], 'RA-treate': [4229]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2953132931', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 23}, {'year': 2022, 'cited_by_count': 28}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-21T21:12:22.825779', 'created_date': '2019-06-27'}
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