Predictive Biomarkers for Immunotherapy in the Treatment of Advanced Urothelial Carcinoma: Where We Stand and Where We Go

Name: Work Video:
Duration: 3 min 30 s
Thomas Gevaert; Alessia Cimadamore; Markus Eckstein; Marina Scarpelli; Antonio López-Beltrán; Liang Cheng; Rodolfo Montironi
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'articleKeywords:': [162], 'atezolizumabbasal-typegenitourinary': [163], 'tumorsimmunotherapyluminal-typelymphocytesmicrobiomePD-L1urothelial': [164, 1246], 'carcinomaReferences1.': [165], 'Mehta': [166], 'K,': [167, 169, 552, 809], 'Patel': [168], 'Parikh': [170], 'RA.': [171], 'Immunotherapy': [172, 243], 'genitourinary': [174, 994], 'malignancies.': [175], 'J.': [176, 235, 315, 386, 578, 753, 776], 'Hematol.': [177], 'Oncol.': [178, 317, 580, 997], '10,': [179, 1109], '95': [180], '(2017).Crossref,': [181, 264, 460, 701, 894], 'Medline,': [182, 209, 265, 321, 346, 391, 439, 461, 503, 545, 584, 614, 647, 667, 702, 758, 781, 832, 856, 874, 895, 922, 949, 977, 1023], 'Google': [183, 211, 248, 266, 323, 348, 393, 415, 440, 463, 505, 547, 586, 616, 649, 668, 704, 729, 760, 783, 804, 834, 858, 876, 897, 924, 951, 979, 1002, 1025], 'Scholar2.': [184], 'Gevaert': [185, 395], 'T,': [186, 396], 'Montironi': [187, 399], 'R,': [188, 982], 'Lopez-Beltran': [189], 'A': [190], 'et': [191, 292, 333, 356, 401, 423, 448, 471, 513, 555, 594, 676, 713, 905, 933, 987], 'al.': [192, 293, 334, 357, 402, 424, 449, 472, 514, 556, 595, 677, 714, 906, 934, 988], 'Genito-urinary': [193], 'genomics': [194], 'emerging': [196], 'immunomodulatory': [199], 'cancer': [200, 255, 281, 426, 487, 750, 887, 966, 1015], 'treatment.': [201], 'Semin.': [202], 'Cancer': [203, 216, 227, 261, 387, 435, 474, 651, 870, 891, 917, 1130], 'Biol.': [204], '52(Pt': [205], '2),': [206], '216–227': [207], '(2018).Crossref,': [208, 320, 583, 613, 803, 948, 976], 'CAS,': [210, 247, 322, 347, 392, 462, 504, 546, 585, 615, 648, 703, 759, 782, 833, 857, 875, 896, 923, 950, 978, 1001, 1024], 'Scholar3.': [212], 'American': [213], 'Association': [214], 'Research.': [217], 'Three': [218], 'drugs': [219], 'approved': [220], 'carcinoma': [223, 307, 372, 524], 'by': [224, 603], 'FDA': [225, 270], '|': [226, 1037, 1071, 1106, 1134, 1176, 1196], 'Discovery.': [228], '(2017)': [229], 'http://cancerdiscovery.aacrjournals.org/content/7/7/659Google': [230], 'Scholar4.': [231], 'Kourie': [232], 'HR,': [233], 'Klastersky': [234], 'Immune': [236, 1119], 'checkpoint': [237, 482], 'inhibitors': [238], 'side': [239], 'effects': [240], 'management.': [242], '8,': [244], '799–807': [245], '(2016).Link,': [246, 1000], 'Scholar5.': [249], 'Goldstein': [250], 'DA.': [251, 815], 'Financial': [252], 'toxicity': [253, 911], 'care': [256], '–': [257], 'edging': [258], 'toward': [259, 821], 'solutions.': [260], '123,': [262], '1301–1302': [263], 'Scholar6.': [267], 'US': [268], 'FDA.': [269], 'limits': [271], 'use': [273, 380], 'Tecentriq': [275], 'Keytruda': [277], 'some': [279], 'patients': [282, 302, 493, 517, 684], '(2018).': [283], 'www.fda.gov/drugs/informationondrugs/approveddrugs/ucm612484.htmGoogle': [284], 'Scholar7.': [285], 'Necchi': [286], 'A,': [287, 289, 732], 'Anichini': [288], 'Raggi': [290], 'D': [291, 593], 'Pembrolizumab': [294], 'as': [295, 565, 679, 1093], 'neoadjuvant': [296], 'therapy': [297, 376], 'before': [298], 'radical': [299], 'cystectomy': [300], 'with': [303, 373, 494, 518, 530, 685, 1101, 1116, 1189, 1260, 1265, 1273], 'muscle-invasive': [304, 454], 'bladder': [306, 455, 632, 661, 1058, 1156], '(PURE-01):': [308], 'an': [309, 822], 'open-label,': [310], 'single-arm,': [311, 534, 693], 'Phase': [312, 536, 695], 'II': [313, 537, 696], 'study.': [314], 'Clin.': [316, 579, 916], '36,': [318, 581], '3353–3360': [319], 'Scholar8.': [324], 'Rijnders': [325], 'M,': [326, 351, 398, 621], 'van': [327], 'der': [328], 'Veldt': [329], 'AAM,': [330], 'Zuiverloon': [331], 'TCM': [332], 'PD-L1': [335, 403, 601, 1114, 1123], 'antibody': [336, 404], 'comparison': [337, 405], 'carcinoma.': [340, 408, 662], 'Eur.': [341, 385, 409, 498, 642, 752], 'Urol.': [342, 410, 499, 643], '75(3),': [343, 644], '538–540': [344], '(2019).Crossref,': [345, 390, 502, 646, 728], 'Scholar9.': [349], 'Eckstein': [350, 397], 'Erbenb': [352], 'P,': [353], 'Kriegmair': [354], 'MC': [355], 'Performance': [358], 'Food': [361], 'Drug': [363, 799, 1078, 1149], 'Administration/EMA-approved': [364], 'programmed': [365], 'cell': [366], 'death': [367], 'ligand-1': [368], 'assays': [369], 'emphasis': [374], 'on': [375, 1065, 1182, 1191, 1211], 'stratification': [377], 'first-line': [379, 680], 'atezolizumab': [382], 'pembrolizumab.': [384], '106,': [388], '234–243': [389], 'Scholar10.': [394], 'R': [400], 'doi:10.1016/j.eururo.2019.01.038': [411], '(2019)': [412], '(In': [413], 'Press).Medline,': [414], 'Scholar11.': [416], 'Lerner': [417], 'SP,': [418], 'McConkey': [419, 469], 'DJ,': [420], 'Hoadley': [421], 'KA': [422], 'Bladder': [425, 434, 1172], 'molecular': [427, 451, 657], 'taxonomy:': [428], 'summary': [429], 'from': [430, 571, 635], 'a': [431, 490, 533, 636, 692, 883, 1094, 1266], 'consensus': [432], 'meeting.': [433], '2(1),': [436], '37–47': [437], '(2016).Crossref,': [438, 544, 780, 1022], 'Scholar12.': [441], 'Robertson': [442], 'AG,': [443], 'Kim': [444, 465], 'J,': [445, 466, 510, 902], 'Al-Ahmadie': [446], 'H': [447], 'Comprehensive': [450, 656], 'characterization': [452, 658], 'cancer.': [456, 867], 'Cell': [457, 1084], '171(3),': [458], '540–556.e25': [459], 'Scholar13.': [464], 'Kwiatkowski': [467], 'D,': [468, 958], 'DJ': [470], 'The': [473, 715, 741, 766, 816, 840, 864, 963, 1008], 'Genome': [475, 652], 'Atlas': [476, 653], 'expression': [477], 'subtypes': [478, 629], 'stratify': [479], 'response': [480, 561, 599], 'inhibition': [483], 'identify': [489], 'subset': [491], 'high': [495], 'survival': [496], 'probability.': [497], '75(6),': [500], '961–964': [501], 'Scholar14.': [506], 'Rosenberg': [507, 674], 'JE,': [508], 'Hoffman-Censits': [509], 'Powles': [511], 'T': [512, 608], 'Atezolizumab': [515, 678], 'locally': [519, 686], 'metastatic': [522, 689], 'who': [525], 'have': [526, 1253], 'progressed': [527], 'following': [528], 'platinum-based': [531], 'chemotherapy:': [532], 'multicentre,': [535, 694], 'trial.': [538, 697], 'Lancet': [539, 698], 'Lond.': [540], 'Engl.': [541, 775], '387,': [542], '1909–1920': [543], 'Scholar15.': [548], 'Teo': [549], 'MY,': [550], 'Seier': [551], 'Ostrovnaya': [553], 'I': [554], 'Alterations': [557], 'DNA': [559], 'damage': [560], 'repair': [563], 'genes': [564], 'potential': [566], 'marker': [567], 'clinical': [569], 'benefit': [570], 'PD-1/PD-L1': [572], 'blockade': [573, 602], 'cancers.': [577, 995], '1685–1694': [582], 'Scholar16.': [587], 'Mariathasan': [588], 'S,': [589, 736, 879, 984], 'Turley': [590], 'SJ,': [591], 'Nickles': [592], 'TGF-β': [596], 'attenuates': [597], 'tumour': [598], 'contributing': [604], 'exclusion': [606], 'cells.': [609], 'Nature': [610, 663], '554,': [611], '544–548': [612], 'Scholar17.': [617], 'Tan': [618, 622], 'TZ,': [619], 'Rouanne': [620], 'KT,': [623], 'Huang': [624], 'RY,': [625], 'Thiery': [626], 'JP.': [627], 'Molecular': [628], 'cancer:': [633, 720, 1157], 'results': [634], 'meta-cohort': [637], 'analysis': [638], '2411': [640], 'tumors.': [641, 944], '423–432': [645], 'Scholar18.': [650], 'Research': [654], 'Network.': [655], '507(7492),': [664], '315–322': [665], '(2014).Crossref,': [666], 'Scholar19.': [669], 'Balar': [670], 'AV,': [671], 'Galsky': [672], 'MD,': [673], 'JE': [675], 'cisplatin-ineligible': [683], '389,': [699], '67–76': [700], 'Scholar20.': [705], 'Massari': [706], 'F,': [707], 'Mollica': [708], 'V,': [709], 'Di': [710], 'Nunno': [711], 'V': [712], 'human': [716, 767, 826, 841], 'microbiota': [717, 745], 'prostate': [719], 'friend': [721], 'or': [722, 1257, 1263, 1270, 1277, 1290, 1295, 1298, 1300], 'foe?': [723], 'Cancers': [724], '(Basel)': [725], '11(4),': [726], 'pii:E459': [727], 'Scholar21.': [730], 'Dzutsev': [731], 'Goldszmid': [733], 'RS,': [734], 'Viaud': [735], 'Zitvogel': [737, 953], 'L,': [738, 811, 954], 'Trinchieri': [739, 880], 'G.': [740, 786, 881], 'role': [742, 1009], 'inflammation,': [747], 'carcinogenesis,': [748], 'therapy.': [751, 888], 'Immunol.': [754], '45,': [755], '17–31': [756], '(2015).Crossref,': [757], 'Scholar22.': [761], 'Lynch': [762], 'SV,': [763], 'Pedersen': [764], 'O.': [765], 'intestinal': [768], 'microbiome': [769, 865, 936, 964], 'health': [771, 847], 'disease.': [773, 794, 849], 'N.': [774], 'Med.': [777, 798], '375,': [778], '2369–2379': [779], 'Scholar23.': [784], 'Reid': [785], 'Microbes': [787], 'food': [789], 'treat': [791], 'prevent': [793], 'Exp.': [795], 'Rev.': [796, 851, 869, 890, 1018], 'Precision': [797, 1075], 'Develop.': [800], '3(2),': [801], '79–81': [802], 'Scholar24.': [805], 'Costello': [806], 'EK,': [807], 'Stagaman': [808], 'Dethlefsen': [810], 'Bohannan': [812], 'BJ,': [813], 'Relman': [814], 'application': [817], 'ecological': [819], 'theory': [820], 'understanding': [823], 'microbiome.': [827], 'Science': [828, 945, 973], '336,': [829], '1255–1262': [830], '(2012).Crossref,': [831, 855], 'Scholar25.': [835], 'Cho': [836], 'I,': [837], 'Blaser': [838], 'MJ.': [839], 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[956], 'Raoult': [957], 'Kroemer': [959], 'Gajewski': [961], 'TF.': [962], 'immunotherapy:': [967], 'diagnostic': [968, 1158], 'tools': [969], 'therapeutic': [971], 'strategies.': [972], '359(6382),': [974], '1366–1370': [975], 'Scholar31.': [980], 'Mazzucchelli': [981], 'Gasparrini': [983], 'Galosi': [985], 'AB': [986], 'Immunotargeting': [989], 'personalized': [991], 'therapies': [992, 1050], '12(16),': [998], '1853–1856': [999], 'Scholar32.': [1003], 'Lovitch': [1004], 'SB,': [1005], 'Rodig': [1006], 'SJ.': [1007], 'surgical': [1011], 'pathology': [1012], 'guiding': [1014], 'immunotherapy.': [1016], 'Annu.': [1017], 'Pathol.': [1019], '11,': [1020], '313–341': [1021], 'ScholarFiguresReferencesRelatedDetailsCited': [1026], 'ByImmune': [1027], 'Checkpoint': [1028, 1166], 'Inhibitors': [1029, 1167], 'Urothelial': [1031, 1102, 1129, 1142], 'Carcinoma': [1032], '(Literature': [1033], 'Review)24': [1034], 'October': [1035], '2022': [1036], 'Creative': [1038], 'surgery': [1039], 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[1124], 'Outcome': [1126], 'Prediction': [1127], 'Patients12': [1131], 'Cancers,': [1135, 1177], '10PD-L1': [1139], 'Testing': [1140], 'Carcinoma:': [1143], 'Interchangeability,': [1144], 'Reliability': [1145], 'PerspectivesCurrent': [1148], 'Targets,': [1150], '22,': [1152], '2Stage': [1154], 'T1': [1155], 'criteria': [1159], 'pitfallsPathology,': [1161], '53,': [1163], '1Immune': [1165], 'Cancer3': [1173], 'January': [1174], '1Update': [1181], 'Genitourinary': [1187], 'Tumors': [1188], 'Focus': [1190], 'Prostate': [1192], 'Cancer19': [1193], 'June': [1194, 1234], '2020': [1195], 'Cells,': [1197], '9,': [1199], '6': [1201], 'eToC': [1206], 'Sign': [1207], 'up': [1208], 'Follow': [1209], 'us': [1210], 'social': [1212], 'media': [1213], 'latest': [1216], 'updates': [1217], 'Metrics': [1218], 'Downloaded': [1219], '283': [1220], 'times': [1221], 'History': [1222], 'Received': [1223], '15': [1224], 'April': [1225], '2019': [1226, 1230, 1235, 1240, 1242], 'Accepted': [1227], '2': [1228], 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