Title: Recent Progress in Radiofluorination of Peptides for PET Molecular Imaging
Abstract:Because of its low positron energy, lack of side emission, and a moderate half-life, Fluorine-18 (β+, 0.635 MeV [97%], t1/2 = 109.8 min) has ideal physical properties for positron emission tomography ...Because of its low positron energy, lack of side emission, and a moderate half-life, Fluorine-18 (β+, 0.635 MeV [97%], t1/2 = 109.8 min) has ideal physical properties for positron emission tomography (PET). With the increasing numbers of peptides that are potentially applicable for molecular imaging of diseases, novel and simple 18F-labeling methods have been actively investigated and reported. In this review, a few well established and widely-used radiofluorination strategies are discussed. Novel approaches including click chemistry, one-step chelation labeling (i.e. Al18F-NOTA), and silicon-based 18F labeling are described as well. Keywords: 18F, Radiofluorination, Positron emission tomography, Peptide, Molecular Imaging, SPECT, chelation labeling, click reaction, HPLCRead More
Publication Year: 2011
Publication Date: 2011-06-20
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 23
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