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'treatment': [24, 72, 209, 382], 'OA.': [26, 450], 'Non-drug': [27], 'therapy': [28, 157], 'aimed': [29], 'at': [30, 194], 'altering': [31], 'eating': [33], 'behavior,': [34], 'allows': [35], 'you': [36], 'to': [37, 52, 411], 'achieve': [38], 'only': [45, 395], '5%,': [46], 'which': [47, 443], 'does': [48], 'not': [49, 367], 'always': [50], 'contribute': [51], 'achievement': [54], 'clinical': [57, 85, 170, 414], 'effect': [58, 446], 'patients': [60, 109, 217, 241, 246, 269, 289, 314, 336, 386], 'with': [61, 75, 112, 138, 212, 290, 309, 315, 333, 337, 387, 391], 'diseases': [62], 'joints.': [65], '<h3>Objectives:</h3>': [66], 'Assess': [67], 'effectiveness': [69, 378], 'complex': [71, 208, 381], 'obesity': [74, 118, 159, 211, 384], 'use': [77, 214, 393], 'orlistat': [79, 131], '(intestinal': [80], 'lipase': [81], 'inhibitor)': [82], 'on': [83, 100, 231, 278, 360, 447], 'manifestations': [86, 415], 'knee': [89, 174, 388, 417], 'OA': [90, 175, 418], 'dynamics': [93], 'cytokines': [95], '(CRP,': [96], 'IL-6,': [97, 201, 358], 'TNF-α)': [98], 'depending': [99, 359], 'degree': [102, 233, 280, 362], 'loss.': [105, 312, 400], '<h3>Methods:</h3>': [106], '50': [107], 'female': [108], '(45-65': [110], 'y.o.)': [111], 'Kellgren-Lawrence': [113], 'stage': [114], 'II-III': [115], 'KOA': [116], '(BMI>30kg/m²).': [119], 'Patients': [120, 147], 'Group': [122, 149, 219, 238, 271], '1': [123, 220], '(n': [124, 151], '=': [125, 152, 328, 343, 348], '25)': [126, 153], 'took': [127], '120': [128], 'mg': [129], '3': [132], 'times': [133], 'day': [135], 'combination': [137], 'low-calorie': [140], 'diet': [141], 'exercise': [143], 'for': [144, 158, 160, 351], '6': [145, 161, 167, 198, 205], 'months.': [146, 162], '2': [150, 272], 'were': [154, 177], 'recommended': [155], 'non-drug': [156], 'At': [163], 'baseline': [164, 195, 334], 'after': [166, 197], 'months,': [168], 'parameters': [171], '(WOMAC)': [176], 'evaluated,': [178], 'quality': [180, 421], 'life': [182, 423], 'was': [183, 192, 266, 325, 366], 'assessed': [184], '(EQ-5D).': [185], 'A': [186, 401, 426], 'laboratory': [187], 'study': [188, 374], 'peripheral': [190], 'blood': [191], 'conducted': [193], 'months:': [199], 'CRP,': [200, 442], 'TNF-α.': [202], '<h3>Results:</h3>': [203], 'After': [204], 'months': [206], 'orlistat,': [216], 'achieved': [221], 'significant': [223, 320, 353, 377], 'loss': [225, 236, 261, 292, 341, 365], '10.07%': [227], '(p': [228, 303, 306, 327, 342, 347], '<0.05).': [229], 'Depending': [230, 277], '1,': [239], '15': [240], 'lost>': [242], '10%': [243, 434], '10': [245], 'lost': [247, 273], '5–9.9%': [248, 339], 'initial': [251], 'weight.': [253], 'In': [254, 313], '2nd': [256], 'group,': [257], 'an': [258, 445], 'insignificant': [259], '0.84%': [263], '(p>': [264], '0.05)': [265], 'achieved,': [267], 'all': [268], 'less': [274, 310], 'than': [275, 294, 297, 408, 433], '5%.': [276], 'loss,': [283], 'it': [284], 'noted': [286], 'that': [287], 'more': [293, 407, 432], '5%': [295, 409], 'better': [296], 'WOMAC': [298], '(pain,': [299], 'stiffness,': [300], 'functional': [301], 'state)': [302], '<0.05),': [304], 'EQ-5D': [305], '<0.05)': [307], 'compared': [308, 332, 390], 'loss>': [317], '10%,': [318], 'CRP': [323], 'level': [324, 440], 'observed': [326], '0.03)': [329, 344], '(Fig.': [330], '1)': [331], '<5%': [346], '0.02).': [349], 'Data': [350], 'statistically': [352], 'changes': [354], 'from': [355], 'TNF-α': [356], 'detected.': [368], '<h3>Conclusion:</h3>': [369], 'results': [371], 'demonstrated': [375], 'OA,': [389], 'non-pharmacological': [396], 'methods': [397], 'mass': [405], 'helps': [410], 'improve': [412], 'patients.': [425], 'demonstrates': [435], 'suggests': [444], 'meta-inflammation': [448], '<h3><b>Disclosure': [451], 'Interests:</b></h3>': [453], 'Ekaterina': [454], 'Strebkova:': [455], 'None': [456], 'declared,': [457], 'Ludmila': [458], 'Alekseeva': [459], 'Speakers': [460], 'bureau:': [461], 'Bayer,': [462], 'Boeringer-ingelheim,': [463], 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