Publication Information

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1151, 1177, 1212, 1301, 1331, 1359, 1385, 1420, 1480, 1527, 1555, 1594, 1770, 1884, 1988], 'Segal': [28, 63, 100, 137, 253, 279, 314, 433, 461, 487, 522, 582, 629, 657, 872, 927, 962, 999, 1036, 1152, 1178, 1213, 1332, 1360, 1386, 1421, 1481, 1528, 1556, 1771, 1885], 'Cancer': [29, 64, 101, 138, 209, 254, 280, 315, 401, 434, 462, 488, 523, 555, 583, 630, 658, 694, 724, 823, 873, 928, 963, 1000, 1037, 1108, 1153, 1179, 1214, 1300, 1333, 1361, 1387, 1422, 1454, 1482, 1529, 1557, 1593, 1623, 1722, 1772, 1886, 1954, 1987, 2006], 'Centre,': [30, 65, 102, 139, 255, 281, 316, 435, 463, 489, 524, 557, 584, 631, 659, 726, 874, 929, 964, 1001, 1038, 1154, 1180, 1215, 1334, 1362, 1388, 1423, 1456, 1483, 1530, 1558, 1625, 1773, 1887, 2008], 'Jewish': [31, 66, 103, 140, 256, 282, 317, 436, 464, 490, 525, 585, 632, 660, 875, 930, 965, 1002, 1039, 1155, 1181, 1216, 1335, 1363, 1389, 1424, 1484, 1531, 1559, 1774, 1888], 'General': [32, 67, 104, 141, 257, 283, 318, 437, 465, 491, 526, 586, 633, 661, 876, 931, 966, 1003, 1040, 1156, 1182, 1217, 1336, 1364, 1390, 1425, 1485, 1532, 1560, 1775, 1889], 'Hospital,': [33, 68, 105, 142, 258, 284, 319, 438, 466, 492, 527, 587, 634, 662, 877, 932, 967, 1004, 1041, 1157, 1183, 1218, 1337, 1365, 1391, 1426, 1486, 1533, 1561, 1776, 1890], 'Montreal,': [34, 43, 69, 78, 106, 116, 143, 153, 259, 285, 294, 320, 330, 350, 371, 382, 439, 467, 493, 502, 528, 537, 560, 588, 597, 607, 635, 663, 675, 729, 751, 762, 774, 787, 878, 887, 897, 907, 933, 942, 968, 977, 1005, 1015, 1042, 1052, 1158, 1184, 1193, 1219, 1229, 1249, 1270, 1281, 1338, 1366, 1392, 1401, 1427, 1436, 1459, 1487, 1496, 1506, 1534, 1562, 1574, 1628, 1650, 1661, 1673, 1686, 1777, 1786, 1796, 1806, 1891, 1900, 1910, 1920, 1968, 1979, 2011, 2023, 2035, 2048], 'QC,': [35, 44, 70, 79, 107, 117, 144, 154, 174, 197, 214, 234, 260, 286, 295, 321, 331, 351, 372, 383, 440, 468, 494, 503, 529, 538, 561, 589, 598, 608, 636, 664, 676, 730, 752, 763, 775, 788, 811, 828, 848, 879, 888, 898, 908, 934, 943, 969, 978, 1006, 1016, 1043, 1053, 1073, 1096, 1113, 1133, 1159, 1185, 1194, 1220, 1230, 1250, 1271, 1282, 1339, 1367, 1393, 1402, 1428, 1437, 1460, 1488, 1497, 1507, 1535, 1563, 1575, 1629, 1651, 1662, 1674, 1687, 1710, 1727, 1747, 1778, 1787, 1797, 1807, 1892, 1901, 1911, 1921, 1930, 1942, 1959, 1969, 1980, 2012, 2024, 2036, 2049], 'Canada': [36, 45, 71, 80, 108, 118, 145, 155, 175, 198, 215, 235, 261, 287, 296, 322, 332, 352, 373, 384, 441, 469, 495, 504, 530, 539, 562, 590, 599, 609, 637, 665, 677, 731, 753, 764, 776, 789, 812, 829, 849, 880, 889, 899, 909, 935, 944, 970, 979, 1007, 1017, 1044, 1054, 1074, 1097, 1114, 1134, 1160, 1186, 1195, 1221, 1231, 1251, 1272, 1283, 1340, 1368, 1394, 1403, 1429, 1438, 1461, 1489, 1498, 1508, 1536, 1564, 1576, 1630, 1652, 1663, 1675, 1688, 1711, 1728, 1748, 1779, 1788, 1798, 1808, 1893, 1902, 1912, 1922, 1931, 1943, 1960, 1970, 1981, 2013, 2025, 2037, 2050], 'Division': [37, 72, 288, 344, 496, 531, 591, 881, 936, 971, 1187, 1243, 1395, 1430, 1490, 1780], 'of': [38, 73, 110, 149, 168, 200, 228, 289, 326, 345, 375, 397, 412, 497, 532, 592, 603, 667, 690, 705, 755, 814, 842, 882, 891, 903, 937, 972, 1009, 1048, 1067, 1099, 1127, 1188, 1225, 1244, 1274, 1296, 1311, 1396, 1431, 1491, 1502, 1566, 1589, 1604, 1654, 1713, 1741, 1781, 1790, 1802, 1895, 1904, 1916, 1924, 1945, 1972, 1983, 1998, 2015, 2074, 2084, 2139, 2168, 2188, 2199, 2247, 2252, 2277, 2317, 2353, 2359, 2370, 2388, 2408, 2437, 2493, 2510, 2531, 2537, 2548, 2578, 2639, 2690, 2710, 2714, 2719, 2722, 2766, 2776, 2788, 2800, 2808, 2837, 2874, 2904, 2908, 2917, 2962, 2966, 2976, 3039, 3057, 3080, 3134, 3151, 3208, 3225, 3249, 3285, 3294, 3348, 3367, 3472, 3521, 3526, 3537, 3618, 3641, 3644, 3657, 3670, 3675, 3681, 3707, 3743, 3757, 3768, 3804, 3808, 3823, 3859, 3915, 3982, 3988, 3996, 4027, 4031, 4097, 4134, 4191, 4196, 4232], 'Experimental': [39, 74, 290, 346, 498, 533, 593, 883, 938, 973, 1189, 1245, 1397, 1432, 1492, 1782, 1896], 'Medicine,': [40, 75, 291, 347, 499, 534, 594, 884, 939, 974, 1190, 1246, 1398, 1433, 1493, 1783, 1897], 'McGill': [41, 76, 114, 151, 292, 328, 348, 380, 500, 535, 558, 595, 605, 727, 760, 885, 895, 905, 940, 975, 1013, 1050, 1191, 1227, 1247, 1279, 1399, 1434, 1457, 1494, 1504, 1626, 1659, 1784, 1794, 1804, 1898, 1908, 1918, 1977, 2009], 'University,': [42, 77, 115, 152, 293, 329, 349, 381, 501, 536, 559, 596, 606, 674, 728, 761, 886, 896, 906, 941, 976, 1014, 1051, 1192, 1228, 1248, 1280, 1400, 1435, 1458, 1495, 1505, 1573, 1627, 1660, 1785, 1795, 1805, 1899, 1909, 1919, 1978, 2010, 2022], 'Search': [46, 81, 119, 156, 176, 216, 236, 262, 297, 333, 353, 385, 416, 442, 470, 505, 540, 563, 610, 638, 678, 709, 732, 790, 830, 850, 910, 945, 980, 1018, 1055, 1075, 1115, 1135, 1161, 1196, 1232, 1252, 1284, 1315, 1341, 1369, 1404, 1439, 1462, 1509, 1537, 1577, 1608, 1631, 1689, 1729, 1749, 1809], 'more': [48, 83, 121, 158, 178, 218, 238, 264, 299, 335, 355, 387, 418, 444, 472, 507, 542, 565, 612, 640, 680, 711, 734, 792, 832, 852, 912, 947, 982, 1020, 1057, 1077, 1117, 1137, 1163, 1198, 1234, 1254, 1286, 1317, 1343, 1371, 1406, 1441, 1464, 1511, 1539, 1579, 1610, 1633, 1691, 1731, 1751, 1811, 4028], 'papers': [49, 84, 122, 159, 179, 219, 239, 265, 300, 336, 356, 388, 419, 445, 473, 508, 543, 566, 613, 641, 681, 712, 735, 793, 833, 853, 913, 948, 983, 1021, 1058, 1078, 1118, 1138, 1164, 1199, 1235, 1255, 1287, 1318, 1344, 1372, 1407, 1442, 1465, 1512, 1540, 1580, 1611, 1634, 1692, 1732, 1752, 1812], 'by': [50, 85, 123, 160, 180, 220, 240, 266, 301, 337, 357, 389, 420, 446, 474, 509, 544, 567, 614, 642, 682, 713, 736, 794, 834, 854, 914, 949, 984, 1022, 1059, 1079, 1119, 1139, 1165, 1200, 1236, 1256, 1288, 1319, 1345, 1373, 1408, 1443, 1466, 1513, 1541, 1581, 1612, 1635, 1693, 1733, 1753, 1813, 2118, 2135, 2215, 2237, 2345, 2544, 2553, 2561, 2575, 2745, 2751, 2779, 2796, 2958, 3035, 3161, 3269, 3274, 3760, 3890, 3894, 4006, 4124, 4227], 'this': [51, 86, 124, 161, 181, 221, 241, 267, 302, 338, 358, 390, 421, 447, 475, 510, 545, 568, 615, 643, 683, 714, 737, 795, 835, 855, 915, 950, 985, 1023, 1060, 1080, 1120, 1140, 1166, 1201, 1237, 1257, 1289, 1320, 1346, 1374, 1409, 1444, 1467, 1514, 1542, 1582, 1613, 1636, 1694, 1734, 1754, 1814, 2056, 3005, 3018, 3423, 3516, 3687, 3967, 4041, 4051, 4112], 'author': [52, 87, 125, 162, 182, 222, 242, 268, 303, 339, 359, 391, 422, 448, 476, 511, 546, 569, 616, 644, 684, 715, 738, 796, 836, 856, 916, 951, 986, 1024, 1061, 1081, 1121, 1141, 1167, 1202, 1238, 1258, 1290, 1321, 1347, 1375, 1410, 1445, 1468, 1515, 1543, 1583, 1614, 1637, 1695, 1735, 1755, 1815, 2096], 'John': [53, 55, 952, 954, 1820], 'Heath': [54, 56, 953, 955], 'Vincent': [88, 91, 987, 990, 1822], 'M': [89, 92, 646, 649, 988, 991, 1545, 1548, 1823, 1863], 'Luo': [90, 93, 989, 992], 'Department': [109, 148, 167, 199, 227, 325, 374, 396, 602, 666, 689, 754, 813, 841, 890, 902, 1008, 1047, 1066, 1098, 1126, 1224, 1273, 1295, 1501, 1565, 1588, 1653, 1712, 1740, 1789, 1801, 1915], 'Microbiology': [111, 892, 1010, 1791, 1905], 'and': [112, 205, 377, 400, 552, 670, 693, 721, 757, 819, 893, 1011, 1104, 1276, 1299, 1451, 1569, 1592, 1620, 1656, 1718, 1792, 1875, 1906, 1950, 1974, 1986, 2003, 2018, 2077, 2095, 2125, 2147, 2149, 2161, 2184, 2194, 2211, 2231, 2234, 2254, 2260, 2265, 2290, 2311, 2335, 2342, 2361, 2379, 2417, 2441, 2465, 2497, 2515, 2557, 2588, 2704, 2770, 2792, 2802, 2839, 2867, 2914, 2972, 3011, 3075, 3085, 3092, 3110, 3174, 3232, 3272, 3323, 3331, 3340, 3433, 3452, 3462, 3481, 3532, 3565, 3588, 3594, 3607, 3625, 3654, 3665, 3689, 3716, 3723, 3764, 3801, 3811, 3848, 3868, 3939, 3958, 4003, 4075, 4093, 4105, 4156, 4183, 4219, 4251, 4280], 'Immunology,': [113, 894, 1012, 1793, 1907], 'Abba': [126, 128, 1025, 1027, 1825], 'Malina': [127, 129, 1026, 1028], 'orcid.org/0000-0002-8511-9005': [130, 1029], 'Gerald': [146, 323, 600, 900, 1045, 1222, 1499, 1799], 'Bronfman': [147, 324, 601, 901, 1046, 1223, 1500, 1800, 1914], 'Oncology,': [150, 327, 604, 904, 1049, 1226, 1503, 1803, 1917], 'Théo': [163, 165, 1062, 1064, 1827], 'Morin': [164, 166, 1063, 1065], 'Biology,': [169, 202, 229, 379, 759, 816, 843, 1068, 1101, 1128, 1278, 1658, 1715, 1742, 1925, 1947, 1976], 'Université': [170, 230, 771, 784, 844, 1069, 1129, 1670, 1683, 1743, 1926, 2032, 2045], 'de': [171, 191, 231, 365, 368, 745, 748, 766, 772, 778, 781, 785, 805, 845, 1070, 1090, 1130, 1264, 1267, 1644, 1647, 1665, 1671, 1677, 1680, 1684, 1704, 1744, 1927, 1936, 1962, 1965, 2027, 2033, 2039, 2042, 2046], 'Sherbrooke,': [172, 173, 232, 233, 846, 847, 1071, 1072, 1131, 1132, 1745, 1746, 1928, 1929], 'Yan': [183, 185, 1082, 1084, 1829], 'Coulombe': [184, 186, 1083, 1085], 'Genome': [187, 801, 1086, 1700], 'Stability': [188, 802, 1087, 1701, 1933], 'Laboratory,': [189, 803, 1088, 1702, 1934], 'CHU': [190, 804, 1089, 1703, 1935], 'Québec': [192, 806, 1091, 1705, 1937], 'Research': [193, 210, 407, 556, 700, 725, 807, 824, 1092, 1109, 1306, 1455, 1599, 1624, 1706, 1723, 1938, 1955, 1993, 2007], 'Center,': [194, 211, 808, 825, 1093, 1110, 1707, 1724, 1939, 1956], 'Quebec': [195, 212, 809, 826, 1094, 1111, 1708, 1725, 1940, 1957], 'City,': [196, 213, 810, 827, 1095, 1112, 1709, 1726, 1941, 1958], 'Molecular': [201, 815, 1100, 1714, 1946], 'Biochemistry': [204, 818, 1103, 1717, 1949], 'Pathology,': [206, 820, 1105, 1719, 1951], 'Laval': [207, 821, 1106, 1720, 1952], 'University': [208, 411, 704, 822, 1107, 1310, 1603, 1721, 1953, 1997], 'Billel': [223, 225, 1122, 1124, 1831], 'Djerir': [224, 226, 1123, 1125], 'Zhigang': [243, 245, 1142, 1144, 1833], 'Li': [244, 246, 1143, 1145], 'Arash': [269, 271, 1168, 1170, 1835], 'Samiei': [270, 272, 1169, 1171], 'Estelle': [304, 306, 1203, 1205, 1837], 'Simo-Cheyou': [305, 307, 1204, 1206], 'Martin': [340, 342, 1239, 1241, 1839], 'Karam': [341, 343, 1240, 1242], 'Halil': [360, 362, 1259, 1261, 1841], 'Bagci': [361, 363, 1260, 1262], 'Institut': [364, 744, 1263, 1643], 'Recherches': [366, 746, 1265, 1645, 1963], 'Cliniques': [367, 747, 1266, 1646, 1964], 'Montréal': [369, 749, 1268, 1648, 1966], '(IRCM),': [370, 750, 1269, 1649, 1967], 'Anatomy': [376, 756, 1275, 1655, 1973], 'Cell': [378, 758, 1277, 1657, 1975, 3704], 'Dolev': [392, 394, 1291, 1293, 1843], 'Rahat': [393, 395, 1292, 1294], 'Developmental': [398, 691, 1297, 1590, 1984], 'Biology': [399, 692, 1298, 1591, 1985], 'The': [403, 409, 696, 702, 1302, 1308, 1595, 1601, 1989, 1995, 2068, 2738, 2986, 3616, 3636, 3784, 3816, 3857], 'Israel-Canada,': [408, 701, 1307, 1600, 1994], 'Hebrew': [410, 703, 1309, 1602, 1996], 'Jerusalem,': [413, 414, 706, 707, 1312, 1313, 1605, 1606, 1999, 2000], 'Israel': [415, 708, 1314, 1607, 2001], 'Damien': [423, 425, 1322, 1324, 1845], 'Grapton': [424, 426, 1323, 1325], 'Elise': [449, 452, 1348, 1351, 1847], 'G': [450, 453, 1349, 1352, 1848], 'Lavoie': [451, 454, 1350, 1353], 'Christian': [477, 479, 1376, 1378, 1850], 'Dove': [478, 480, 1377, 1379], 'Husam': [512, 514, 1411, 1413, 1852], 'Khaled': [513, 515, 1412, 1414], 'Hellen': [547, 549, 1446, 1448, 1854], 'Kuasne': [548, 550, 1447, 1449], 'Rosalind': [551, 720, 1450, 1619], 'Morris': [553, 722, 1452, 1621, 2004], 'Goodman': [554, 723, 1453, 1622, 2005], 'Koren': [570, 573, 1469, 1472, 1856], 'K': [571, 574, 1470, 1473, 1857], 'Mann': [572, 575, 1471, 1474], 'Kathleen': [617, 620, 1516, 1519, 1859], 'Oros': [618, 621, 1517, 1520, 1860], 'Klein': [619, 622, 1518, 1521], 'Celia': [645, 648, 1544, 1547, 1862], 'Greenwood': [647, 650, 1546, 1549], 'Epidemiology,': [668, 1567, 2016], 'Biostatistics': [669, 1568, 2017], 'Occupational': [671, 1570, 2019], 'Health,': [672, 1571, 2020], 'MGill': [673, 1572, 2021], 'Yuval': [685, 687, 1584, 1586, 1865], 'Tabach': [686, 688, 1585, 1587], 'Morag': [716, 718, 1615, 1617, 1867], 'Park': [717, 719, 1616, 1618], 'Jean-Francois': [739, 741, 1638, 1640, 1869], 'Côté': [740, 742, 1639, 1641], 'orcid.org/0000-0001-7055-2642': [743, 1642], 'Département': [765, 777, 1664, 1676], 'Biochimie': [767, 1666, 2028], 'et': [768, 1667, 2029, 2472, 2568, 2591, 2596, 2601, 2605, 2609, 2613, 2617, 2621, 2659, 2663, 2667, 2672, 2676, 2680, 2684, 2735, 2815, 2820, 2824, 2879, 2883, 2924, 2932, 2950, 2983, 3214, 3241, 3370, 3378, 3382, 3386, 3390, 3394, 3398, 3402, 3406, 3414, 3418, 3459, 3494, 3933, 3970, 3974, 3978, 4108, 4137], 'Médecine': [769, 779, 1668, 1678, 2030, 2040], 'Moléculaire,': [770, 1669, 2031], 'Montréal,': [773, 786, 1672, 1685, 2034, 2047], '(Programmes': [780, 1679, 2041], 'Biologie': [782, 1681, 2043], 'Moléculaire),': [783, 1682, 2044], 'Jean-Yves': [797, 799, 1696, 1698, 1871], 'Masson': [798, 800, 1697, 1699], 'Alexandre': [837, 839, 857, 861, 1736, 1738, 1756, 1760, 1873, 1876], 'Maréchal': [838, 840, 1737, 1739], 'Orthwein': [858, 862, 1757, 1761, 1877], 'Corresponding': [859, 1758], 'Author': [860, 1759, 1816], '[email': [863, 1762, 2066], 'protected]': [864, 1763, 2067], 'orcid.org/0000-0002-7350-3413': [865, 1764], 'Information': [1817], 'Findlay1,2,‡,': [1819], 'Heath1,2,‡,': [1821], 'Luo1,3,': [1824], 'Malina1,4,': [1826], 'Morin5,': [1828], 'Coulombe6,7,': [1830], 'Djerir5,': [1832], 'Li1,': [1834], 'Samiei1,2,': [1836], 'Simo-Cheyou1,4,': [1838], 'Karam2,': [1840], 'Bagci8,9,': [1842], 'Rahat10,': [1844], 'Grapton1,': [1846], 'Lavoie1,': [1849], 'Dove1,2,': [1851], 'Khaled1,2,': [1853], 'Kuasne11,': [1855], 'Mann1,2,4,': [1858], 'Klein1,': [1861], 'Greenwood1,12,': [1864], 'Tabach10,': [1866], 'Park11,': [1868], 'Côté8,9,13,14,': [1870], 'Masson6,7,': [1872], 'Maréchal5': [1874], '*,1,2,3,4': [1878], '1Lady': [1879], '2Division': [1894], '3Department': [1903], '4Gerald': [1913], '5Department': [1923], '6Genome': [1932], '7Department': [1944], '8Institut': [1961], '9Department': [1971], '10Department': [1982], '11Rosalind': [2002], '12Department': [2014], '13Département': [2026], '14Département': [2038], '‡These': [2051], 'authors': [2052], 'contributed': [2053], 'equally': [2054], 'work': [2057], '*Corresponding': [2058], 'author.': [2059], 'Tel:': [2060], '+1': [2061], '514': [2062], '340': [2063], '8222;': [2064], 'E-mail:': [2065], 'EMBO': [2069], 'Journal': [2070], '(2018)37:e100158https://doi.org/10.15252/embj.2018100158': [2071], 'PDFDownload': [2072], 'PDF': [2073], 'article': [2075], 'text': [2076], 'main': [2078], 'figures.': [2079], 'Peer': [2080], 'ReviewDownload': [2081], 'a': [2082, 2173, 2228, 2248, 2274, 2354, 2365, 2434, 2545, 2628, 2640, 2648, 2726, 2760, 2918, 2939, 2963, 2997, 3042, 3072, 3119, 3155, 3193, 3198, 3223, 3441, 3469, 3571, 3613, 3895, 3922, 4025, 4087, 4131, 4188, 4203, 4222, 4278], 'summary': [2083], 'the': [2085, 2136, 2156, 2165, 2169, 2186, 2202, 2281, 2299, 2304, 2368, 2389, 2448, 2453, 2487, 2491, 2494, 2498, 2508, 2529, 2534, 2538, 2549, 2554, 2576, 2637, 2691, 2711, 2717, 2752, 2763, 2774, 2777, 2780, 2786, 2798, 2834, 2851, 2859, 2875, 2902, 2906, 2909, 2915, 2967, 2973, 2977, 2993, 3027, 3037, 3060, 3123, 3149, 3171, 3178, 3187, 3206, 3289, 3292, 3295, 3313, 3321, 3324, 3436, 3463, 3473, 3507, 3533, 3623, 3626, 3639, 3642, 3647, 3652, 3655, 3663, 3676, 3698, 3713, 3731, 3749, 3755, 3762, 3765, 3820, 3833, 3844, 3849, 3872, 3880, 3913, 3936, 3983, 3994, 3997, 4032, 4037, 4095, 4126, 4157, 4161, 4194, 4233, 4271, 4284, 4288, 4291, 4295], 'editorial': [2086, 2090], 'decision': [2087, 2091, 2476], 'including': [2089, 2486, 2636, 3435], 'letters,': [2092], 'reviewer': [2093], 'comments': [2094], 'responses': [2097], 'feedback.': [2099], 'ToolsAdd': [2100], 'favoritesDownload': [2102], 'CitationsTrack': [2103], 'CitationsPermissions': [2104], 'ShareFacebookTwitterLinked': [2105], 'InMendeleyWechatReddit': [2106], 'Figures': [2107], '&': [2108, 2423, 2520, 2928, 3374, 3410, 3486, 3490], 'Info': [2109], 'Abstract': [2110], 'breaks': [2113, 2321, 2384], '(DSBs)': [2114, 2385], 'can': [2115, 2397, 2705], 'be': [2116, 4080], 'repaired': [2117], 'two': [2119, 2456, 2511], 'major': [2120], 'pathways:': [2121, 2461], 'non-homologous': [2122, 2313, 2462], 'end-joining': [2123, 2314, 2463, 2524], '(NHEJ)': [2124, 2315, 2464], 'homologous': [2126, 2308, 2466], 'recombination': [2127, 2218, 2309, 2467, 2646], '(HR).': [2128], 'is': [2133, 2245, 2331, 2351, 2364, 2506, 2525, 2542, 2573, 2702, 2716, 2748, 2887, 2938, 3247, 3666], 'governed': [2134], 'opposing': [2137, 2835], 'activities': [2138], '53BP1,': [2140], 'in': [2141, 2201, 2220, 2227, 2279, 2399, 2421, 2452, 2470, 2518, 2528, 2566, 2631, 2655, 2733, 2811, 2831, 2841, 2871, 2898, 2942, 2948, 2992, 2996, 3059, 3071, 3098, 3106, 3177, 3235, 3254, 3281, 3288, 3319, 3345, 3506, 3686, 4040, 4058, 4067, 4180, 4193, 4206, 4217, 4253], 'complex': [2142, 2158, 2250, 2357, 2435, 2964, 3475], 'its': [2144, 2584, 2803, 2896, 3068, 3453, 4056], 'effectors': [2145, 2301, 2585, 2805], 'RIF1': [2146, 3957, 4179], 'REV7,': [2148, 2587, 2864, 3152, 3769, 3959], 'BRCA1.': [2150], 'However,': [2151, 3497], 'it': [2152, 2854], 'remains': [2153, 2855, 3510], 'unknown': [2154], 'how': [2155, 2858, 3004], '53BP1/RIF1/REV7': [2157, 2305], 'stimulates': [2159], 'NHEJ': [2160, 2203, 2264, 2341, 2572, 2866, 2994, 3061, 3084, 3109, 3750, 3930, 4007], 'restricts': [2162], 'HR': [2163, 2236, 2344, 2701, 2715, 2781, 2870, 2959], 'S/G2': [2166, 2688, 2812], 'phases': [2167, 2689, 2813], 'cell': [2170, 2418, 2488, 2539, 2692, 2876, 3184, 4013], 'cycle.': [2171, 2540], 'Using': [2172, 3041, 3422], 'mass': [2174, 3043], 'spectrometry': [2175, 2324, 3044], '(MS)-based': [2176, 3045], 'approach,': [2177, 3046, 3195], 'we': [2178, 3021, 3047, 3153, 3196, 3358, 3425, 3920, 3954, 4046, 4085], 'identify': [2179, 2295], '11': [2180, 3427, 3678, 3984], 'high-confidence': [2181, 3305, 3428, 3500, 3679], 'interactors': [2183, 3307, 3430, 3502, 3680, 3746, 3917, 3991], 'elucidate': [2185], 'role': [2187, 2630, 2836, 2897, 3454, 3505, 4190, 4205], 'SHLD2': [2189, 2272, 2330, 2339, 2350, 2363, 3049, 4018, 4063, 4078, 4102, 4172, 4176, 4192, 4201, 4216], '(previously': [2190, 2256, 3050, 3102], 'annotated': [2191, 2257], 'as': [2192, 2196, 2258, 2273, 2298, 2327, 2699, 2953, 2955, 2960, 3052, 3054, 3104, 3237, 3556, 3570, 3598, 3612, 3668, 3684, 3730, 3781, 3794, 3879, 4020, 4160, 4277], 'FAM35A': [2193, 2205, 2223, 2244, 3063, 3081, 3096], 'RINN2)': [2195], 'an': [2197, 2888, 3055, 3226, 3544, 3578, 4072, 4228], 'effector': [2198, 2276, 3056], 'pathway.': [2204, 3062], 'depletion': [2206, 3079], 'impairs': [2207, 3082], 'NHEJ-mediated': [2208], 'compromises': [2212], 'antibody': [2213], 'diversification': [2214], 'class': [2216, 2644], 'switch': [2217, 2645], '(CSR)': [2219], 'B': [2221, 2656], 'cells.': [2222], 'accumulates': [2224, 3064], 'at': [2225, 2580, 3065], 'DSBs': [2226, 2334, 2532, 3066], '53BP1-,': [2229, 3073], 'RIF1-,': [2230, 3074], 'REV7-dependent': [2232, 3076], 'manner': [2233, 2999], 'antagonizes': [2235, 2307, 2343], 'limiting': [2238], 'end': [2240, 2348, 2730, 2790, 3090], 'resection.': [2241, 2349], 'In': [2242, 2687, 2935, 3017, 3094], 'fact,': [2243, 3095], 'part': [2246, 2352, 2961], 'larger': [2249, 2355], 'composed': [2251, 2358, 2965], 'SHLD1': [2255, 3101], 'C20orf196': [2259], 'RINN3),': [2261], 'which': [2262, 2303, 2747, 3204, 3960, 4185], 'promotes': [2263, 2312, 2336, 2340, 2785, 3008, 4064], 'limits': [2266], 'HR.': [2267, 3093, 3114], 'Together,': [2268], 'these': [2269, 2428, 3499, 3916], 'results': [2270, 3117], 'establish': [2271], 'novel': [2275, 3744, 4088], 'controlling': [2280], 'decision-making': [2282, 3028], 'during': [2284, 2447, 2533, 2643, 3455], 'DSB': [2285, 2449, 2778, 2794, 2956, 3009, 3508, 4001, 4065], 'repair.': [2286, 2338], 'Synopsis': [2287], 'Proteomic': [2288], 'interaction': [2289, 3529], 'CRISPR/Cas9': [2291], 'doxorubicin': [2292], 'sensitivity': [2293], 'screens': [2294], 'shieldin': [2296], 'proteins': [2297, 2438, 3251, 3265, 3758], 'sought-after': [2300], 'through': [2302, 2901, 3067, 3701], 'axis': [2306], '(HR)': [2310], 'double': [2319], 'strand': [2320, 2768, 2771], '(DSB).': [2322], 'Mass': [2323], 'identifies': [2325], 'interactor.': [2329], 'recruited': [2332], 'their': [2337, 2376, 2558, 3690], 'inhibiting': [2346], 'multi-protein': [2356], 'SHLD1/C20orf196.': [2362], 'biomarker': [2366], 'prognosis': [2369], 'TNBC/basal-like': [2371], 'BC.': [2372], 'Introduction': [2373], 'Due': [2374], 'highly': [2377], 'recombinogenic': [2378], 'pro-apoptotic': [2380], 'potential,': [2381], 'are': [2386, 2697, 2742, 2759, 3695, 3728, 3792, 3877, 4275, 4297], 'one': [2387], 'most': [2390, 4162], 'cytotoxic': [2391], 'lesions.': [2393], 'Their': [2394], 'inaccurate': [2395], 'resolution': [2396, 2775], 'result': [2398], 'point': [2400], 'mutations,': [2401], 'small': [2402, 3944], 'deletions/insertions,': [2403], 'chromosomal': [2404], 'rearrangements,': [2405], 'or': [2406, 3257, 3291, 3317, 3581, 3771, 4243], 'loss': [2407], 'gross': [2409], 'genetic': [2410], 'information': [2411], 'that': [2412, 2652, 2758, 2891, 2989, 3126, 3252, 3308, 3445, 3477, 3649, 3927, 4099, 4128, 4169], 'drive': [2413], 'genomic': [2414], 'instability,': [2415], 'carcinogenesis,': [2416], 'death': [2419], '(reviewed': [2420, 2517, 2565, 2732], 'Tubbs': [2422], 'Nussenzweig,': [2424], '2017).': [2425, 3421], 'To': [2426, 3144, 3353, 3911, 4070], 'avoid': [2427], 'deleterious': [2429], 'outcomes,': [2430], 'cells': [2431, 2657, 3286, 3541, 3575, 3710, 3829, 3840, 3861, 4069, 4238], 'have': [2432, 3961], 'deployed': [2433], 'network': [2436], 'signal': [2440, 3999, 4034], 'DSBs.': [2443, 2708], 'One': [2444, 2709], 'critical': [2445, 3337, 3470, 4204], 'step': [2446], 'response': [2450, 3509], 'consists': [2451], 'between': [2455], 'mutually': [2457], 'exclusive': [2458], '(HR;': [2468], 'reviewed': [2469, 2947], 'Ceccaldi': [2471], 'al,': [2473, 2569, 2592, 2597, 2602, 2606, 2610, 2614, 2618, 2622, 2660, 2664, 2668, 2673, 2677, 2681, 2685, 2736, 2816, 2821, 2825, 2880, 2884, 2925, 2933, 2951, 2984, 3215, 3242, 3371, 3379, 3383, 3387, 3391, 3395, 3399, 3403, 3407, 3415, 3419, 3460, 3495, 3934, 3971, 3975, 3979, 4109, 4138], '2016).': [2474, 2522, 2737], 'This': [2475, 3244], 'process,': [2477], 'named': [2478], 'choice,': [2482], 'integrates': [2483], 'several': [2484, 2632], 'elements': [2485], 'cycle': [2489, 2693, 2877, 3465, 3705, 4014], 'status,': [2490], 'complexity': [2492], 'end,': [2496], 'epigenetic': [2499], 'context.': [2500], 'Importantly,': [2501, 2571, 3078, 4111], 'under': [2507, 4257], 'control': [2509, 2903, 3127, 4038], 'antagonizing': [2512, 2828, 3113], 'factors,': [2513], '53BP1': [2514, 2579, 2801, 2829, 2838, 2860], 'BRCA1': [2516, 2784, 2840], 'Hustedt': [2519], 'Durocher,': [2521], 'Non-homologous': [2523], 'predominantly': [2526], 'involved': [2527], 'G1': [2535, 2872], 'phase': [2536, 2873], 'It': [2541], 'characterized': [2543], 'limited': [2546], 'processing': [2547], 'ends': [2551], 'catalyzed': [2552], 'nuclease': [2555], 'Artemis': [2556], 'subsequent': [2559, 2764, 4004], 'ligation': [2560], 'ligase': [2563], 'IV': [2564], 'Betermier': [2567], '2014).': [2570], 'promoted': [2574], 'recruitment': [2577, 2799], 'DSBs,': [2581], 'along': [2582], 'RIF1,': [2586], 'PTIP': [2589], '(Chapman': [2590, 2814, 3969], '2012,': [2593, 2817, 3216], '2013;': [2594, 2598, 2603, 2607, 2611, 2615, 2669, 2674, 2678, 2818, 2822, 2930, 3412, 3492, 3972, 3976], 'Callen': [2595], 'Di': [2599, 2670], 'Virgilio': [2600, 2671], 'Escribano-Diaz': [2604, 2675, 2819, 3973], 'Feng': [2608, 2823], 'Zimmermann': [2612], 'Boersma': [2616, 2679, 3977], '2015;': [2619, 2682, 2881], 'Xu': [2620, 2683, 2882], '2015).': [2623, 2686, 2885, 2934, 3243, 3496, 3980], 'These': [2624], 'latter': [2625], 'factors': [2626], 'play': [2627, 3503], 'central': [2629], 'additional': [2633], 'biological': [2634, 4144, 4164], 'processes,': [2635], 'establishment': [2638], 'protective': [2641], 'immunity': [2642], '(CSR),': [2647], 'programmed': [2649], 'DSB-dependent': [2650], 'specifically': [2653], 'occurs': [2654], '(Manis': [2658], '2004;': [2661, 2665], 'Ward': [2662], 'Chapman': [2666], '(when': [2694], 'sister': [2695], 'chromatids': [2696], 'available': [2698], 'templates),': [2700], 'activated': [2703], 'alternatively': [2706], 'key': [2712], 'features': [2713], 'formation': [2718, 2916], 'long': [2720], 'stretches': [2721, 2741], 'single-stranded': [2723], '(ssDNA),': [2725], 'called': [2728], 'resection': [2731, 2791, 3091], 'Fradet-Turcotte': [2734], 'resulting': [2739], 'ssDNA': [2740], 'rapidly': [2743], 'coated': [2744], 'RPA,': [2746], 'subsequently': [2749, 3267, 3717, 3869], 'replaced': [2750], 'recombinase': [2753], 'RAD51': [2754], 'form': [2756], 'nucleofilaments': [2757], 'pre-requisite': [2761], 'search': [2765], 'homology,': [2767], 'invasion,': [2769], 'exchange': [2772], 'before': [2773], 'machinery.': [2782], 'Critically,': [2783], 'initiation': [2787], 'HR-mediated': [2793], 'preventing': [2797], 'downstream': [2804, 2861], 'sites': [2807], 'damage': [2810, 3774], '2013),': [2826], 'thereby': [2827], 'function': [2830, 4123], 'NHEJ.': [2832], 'While': [2833], 'has': [2846, 2892, 3446, 4115], 'been': [2847, 2893, 3447, 3962, 4116], 'extensively': [2848], 'scrutinized': [2849], 'over': [2850, 3825], 'past': [2852], 'years,': [2853], 'largely': [2856], 'unclear': [2857], 'effectors,': [2862], 'namely': [2863], 'promote': [2865], 'antagonize': [2868], 'BRCA1-mediated': [2869], '(Boersma': [2878], 'adaptor': [2889, 3006], 'protein': [2890, 3007, 3246, 3444, 3466, 3791, 4122], 'described': [2894, 3239, 3692], 'mitotic': [2899, 3456], 'progression': [2900, 3457, 4015], 'both': [2905, 3083, 3108, 3320, 3622, 3761, 3956, 4181], 'activity': [2907], 'spindle': [2910], 'assembly': [2911], 'checkpoint': [2912], '(SAC)': [2913], 'functional': [2919], 'anaphase-promoting': [2920, 3474], 'complex/cyclosome-Cdc20': [2921], '(APC/C;': [2922], 'Cahill': [2923], '1999;': [2926, 3372], 'Listovsky': [2927, 3409, 3489], 'Sale,': [2929, 3411, 3491], 'Bhat': [2931, 3493], 'parallel,': [2936], 'well-defined': [2940], 'player': [2941], 'translesion': [2944], 'synthesis': [2945], '(TLS;': [2946], 'Waters': [2949], '2009)': [2952], 'well': [2954], 'deoxycytidyl': [2968], '(dCMP)': [2969], 'transferase': [2970], 'REV1': [2971], 'catalytic': [2974], 'subunit': [2975], 'polymerase': [2979], 'ζ,': [2980], 'REV3L': [2981], '(Sharma': [2982], '2012).': [2985], 'recent': [2987], 'discovery': [2988], 'participates': [2991], 'TLS-independent': [2998], 'raised': [3000], 'fundamental': [3001], 'questions': [3002], 'about': [3003], 'controls': [3012], 'choice.': [3016, 3131, 4062], 'present': [3019], 'study,': [3020], 'sought': [3022], 'get': [3024, 3145, 4071], 'insight': [3025, 3121, 3147], 'into': [3026, 3122, 3148, 3483], 'underpinning': [3030], 'deciphering': [3036], 'interactome': [3038, 3150, 3523, 3617], 'REV7.': [3040, 3566], 'identified': [3048, 3273, 3303, 3759, 4147], 'known': [3051, 3103, 3659], 'FAM35A/RINN2)': [3053], 'N-terminal': [3069], 'domain': [3070], 'manner.': [3077], 'CSR,': [3086], 'while': [3087, 3112, 4294], 'promoting': [3088, 3107], 'acts': [3097], 'concert': [3099], 'C20orf196/RINN3)': [3105], 'CSR': [3111], 'Altogether,': [3115], 'our': [3116, 3346, 3360, 4021, 4048], 'provide': [3118], 'better': [3120, 3146, 4054], 'molecular': [3124], 'events': [3125, 3931], 'Results': [3132], 'Mapping': [3133], 'proximal/interacting': [3136], 'partners': [3137, 3350], 'relevant': [3138, 3747, 4081], 'performed': [3154, 4268], 'standard': [3156, 3766], 'affinity': [3157, 3271], 'purification': [3158], '(AP)': [3159], 'followed': [3160, 3893, 4226], 'MS': [3162], '(AP-MS;': [3163], 'Fig': [3164], 'EV1A),': [3165], 'where': [3166, 4283], 'was': [3168, 3220, 3568, 3610, 3629, 3852, 3862, 3888, 4267], 'tagged': [3169], 'Flag': [3172], 'epitope': [3173], 'stably': [3175, 3233, 3542, 3576, 4239], 'expressed': [3176, 3234], 'human': [3179, 4068], 'embryonic': [3180], 'kidney': [3181], '293': [3182], '(HEK293)': [3183], 'line': [3185], 'using': [3186, 3283, 3634, 3943, 4221], 'Flp-In/T-REX': [3188], 'system': [3189], '(Fig': [3190, 3211, 3262, 3329, 3351, 3949, 4008, 4016, 4043, 4173], 'EV1B).': [3191], 'As': [3192, 3334, 3951], 'complementary': [3194], 'used': [3197, 3569, 3611, 3921, 4086], 'proximity-based': [3199], 'biotin': [3200, 3597], 'labeling': [3201], 'technique': [3202], '(BioID),': [3203], 'allows': [3205, 3478], 'monitoring': [3207], 'proximal/transient': [3209], 'interactions': [3210], 'EV1A;': [3212], 'Roux': [3213], '2013).': [3217], 'Briefly,': [3218], 'fused': [3221], 'mutant': [3224], 'Escherichia': [3227], 'coli': [3228], 'biotin-conjugating': [3229], 'enzyme': [3230], '(BirA*)': [3231], 'HEK293': [3236], 'previously': [3238, 3363, 3691, 3963, 4117], '(Lambert': [3240], 'fusion': [3245], 'capable': [3248], 'biotinylating': [3250], 'come': [3253], 'close': [3255], 'proximity': [3256], 'directly': [3258], 'interact': [3259], 'EV1C).': [3263], 'Labeled': [3264], 'were': [3266, 3278, 3309, 3343, 3548, 3561, 3584, 3603, 3797, 3830, 3841, 4245], 'purified': [3268], 'streptavidin': [3270], 'MS.': [3275], 'Both': [3276], 'approaches': [3277, 3628], 'carried': [3279], 'out': [3280], 'triplicate': [3282], 'extracts': [3284], 'treated': [3287], 'absence': [3290], 'presence': [3293], 'radiomimetic': [3296], 'damaging': [3298], 'drug': [3299], 'neocarzinostatin': [3300], '(NCS).': [3301, 3775], 'We': [3302], '140': [3304], 'either': [3310], 'common': [3311], 'four': [3314], 'experimental': [3315], 'conditions': [3316], 'found': [3318], 'AP-MS': [3322, 3527, 3624], 'BioID': [3325, 3534, 3627, 3763, 3777], 'following': [3326, 3552, 3590, 3697, 4000], 'NCS': [3327], 'treatment': [3328], '1A': [3330], 'Table': [3332], 'EV1).': [3333], 'expected,': [3335], 'pathways': [3336], 'mitosis': [3339], 'enriched': [3344], 'list': [3347], 'EV1D).': [3352], 'further': [3354, 4186], 'refine': [3355], 'interactors,': [3357], 'intersected': [3359], 'data': [3361], 'reported': [3364], 'proteomic': [3365], 'profiling': [3366, 4090, 4224], '(Nelson': [3369], 'Chen': [3373], 'Fang,': [3375, 3487], '2001;': [3376, 3380, 3488], 'Weterman': [3377], 'Guo': [3381], '2003;': [3384], 'Iwai': [3385], '2007;': [3388, 3392], 'Zhang': [3389], 'Hong': [3393], '2009;': [3396, 3400], 'Medendorp': [3397], 'Tissier': [3401], '2010;': [3404, 3408], 'Vermeulen': [3405], 'Rolland': [3413], '2014;': [3416], 'Huttlin': [3417], '2015,': [3420], 'methodology,': [3424], 'obtained': [3426, 3620], '(Figs': [3431], '1B': [3432], 'EV1E),': [3434], 'chromosome': [3437], 'alignment-maintaining': [3438], 'phosphoprotein': [3439], '(CHAMP1),': [3440], 'kinetochore-microtubule': [3442], 'attachment': [3443], 'recently': [3448], 'linked': [3449], '(Itoh': [3458], '2011),': [3461], 'cell-division': [3464], '20': [3467], '(CDC20),': [3468], 'activator': [3471], '(APC/C)': [3476], 'chromatid': [3479], 'separation': [3480], 'entrance': [3482], 'anaphase': [3484], '(Chen': [3485], 'whether': [3498, 4077], 'any': [3504], 'unresolved.': [3511], 'Click': [3512], 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