Title: Synthesis of trans β-Lactams of Estrane Series
Abstract: 17,17-Ethylenedioxy-1,3,5(10)-estratrien-3β-ol ( I ) was converted into ethyl ester II by reaction with ethyl chloroacetate in the presence of potassium. The ethyl ester II on reaction with hydrazine gave hydrazide III , which on condensation with aromatic aldehydes gave Schiff bases IVa - IVd . The reaction of Schiff bases IVa - IVd with chloroacetyl chloride in the presence of triethylamine afforded β-lactams Va - Vd .
Publication Year: 1995
Publication Date: 1995-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 5
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