Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2952184832', 'doi': 'https://doi.org/10.1021/jm00055a013', 'title': 'Dibenz[b,e]oxepin derivatives: novel antiallergic agents possessing thromboxane A2 and histamine H1 dual antagonizing activity. 1', 'display_name': 'Dibenz[b,e]oxepin derivatives: novel antiallergic agents possessing thromboxane A2 and histamine H1 dual antagonizing activity. 1', 'publication_year': 1993, 'publication_date': '1993-02-01', 'ids': {'openalex': 'https://openalex.org/W2952184832', 'doi': 'https://doi.org/10.1021/jm00055a013', 'mag': '2952184832', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8093908'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm00055a013', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111900989', 'display_name': 'Eriko Ohshima', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205823427', 'display_name': 'Kyowa Kirin (Japan)', 'ror': 'https://ror.org/000wej815', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I205823427']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'E Ohshima', 'raw_affiliation_strings': ['Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Shizuoka-ken, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Shizuoka-ken, Japan.', 'institution_ids': ['https://openalex.org/I205823427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006349141', 'display_name': 'Hitoshi Takami', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H Takami', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042057397', 'display_name': 'Hiroyuki Harakawa', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H Harakawa', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038640614', 'display_name': 'Hideyuki Sato', 'orcid': 'https://orcid.org/0000-0002-5155-2003'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H Sato', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012790695', 'display_name': 'H. OBASE', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H Obase', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057924266', 'display_name': 'Ichiro Miki', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'I Miki', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000615190', 'display_name': 'Akio Ishii', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A Ishii', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010965600', 'display_name': 'Hidee Ishii', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H Ishii', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012602916', 'display_name': 'Yasuo Sasaki', 'orcid': 'https://orcid.org/0000-0003-0450-2764'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Y Sasaki', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108195536', 'display_name': 'Kenji Ohmori', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'K Ohmori', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.133, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.624751, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '36', 'issue': '3', 'first_page': '417', 'last_page': '420'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13454', 'display_name': 'Phenothiazines and Benzothiazines Synthesis and Activities', 'score': 0.9883, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13454', 'display_name': 'Phenothiazines and Benzothiazines Synthesis and Activities', 'score': 0.9883, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11346', 'display_name': 'Mast cells and histamine', 'score': 0.9872, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10911', 'display_name': 'Chemical Synthesis and Analysis', 'score': 0.9869, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.9428184}, {'id': 'https://openalex.org/C1122143', 'wikidata': 'https://www.wikidata.org/wiki/Q61233', 'display_name': 'Histamine', 'level': 2, 'score': 0.867697}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.526261}, {'id': 'https://openalex.org/C2776785769', 'wikidata': 'https://www.wikidata.org/wiki/Q412212', 'display_name': 'Thromboxane', 'level': 3, 'score': 0.4482475}, {'id': 'https://openalex.org/C2781024287', 'wikidata': 'https://www.wikidata.org/wiki/Q774909', 'display_name': 'Thromboxane A2', 'level': 3, 'score': 0.44510692}, {'id': 'https://openalex.org/C2780980858', 'wikidata': 'https://www.wikidata.org/wiki/Q110022', 'display_name': 'Dual (grammatical number)', 'level': 2, 'score': 0.4143563}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2562207}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.15818664}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.14127827}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.117581755}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C142362112', 'wikidata': 'https://www.wikidata.org/wiki/Q735', 'display_name': 'Art', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C124952713', 'wikidata': 'https://www.wikidata.org/wiki/Q8242', 'display_name': 'Literature', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003990', 'descriptor_name': 'Dibenzoxepins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D003990', 'descriptor_name': 'Dibenzoxepins', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D006634', 'descriptor_name': 'Histamine H1 Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D006634', 'descriptor_name': 'Histamine H1 Antagonists', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D013928', 'descriptor_name': 'Thromboxane A2', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003990', 'descriptor_name': 'Dibenzoxepins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006168', 'descriptor_name': 'Guinea Pigs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006634', 'descriptor_name': 'Histamine H1 Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011982', 'descriptor_name': 'Receptors, Prostaglandin', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011982', 'descriptor_name': 'Receptors, Prostaglandin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017482', 'descriptor_name': 'Receptors, Thromboxane', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017482', 'descriptor_name': 'Receptors, Thromboxane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044244', 'descriptor_name': 'Receptors, Thromboxane A2, Prostaglandin H2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013928', 'descriptor_name': 'Thromboxane A2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/jm00055a013', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8093908', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/2', 'score': 0.48, 'display_name': 'Zero hunger'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W98406121', 'https://openalex.org/W3137925955', 'https://openalex.org/W2412325289', 'https://openalex.org/W2347134004', 'https://openalex.org/W2254517775', 'https://openalex.org/W2072764216', 'https://openalex.org/W2053182919', 'https://openalex.org/W2010417523', 'https://openalex.org/W2010146877', 'https://openalex.org/W1998530272'], 'abstract_inverted_index': {'ADVERTISEMENT': [0], 'RETURN': [1], 'TO': [2], 'ISSUEPREVArticleNEXTDibenz[b,e]oxepin': [3], 'derivatives:': [4], 'novel': [5], 'antiallergic': [6], 'agents': [7], 'possessing': [8], 'thromboxane': [9], 'A2': [10], 'and': [11, 35, 80, 85, 114, 158, 175, 191, 193], 'histamine': [12], 'H1': [13], 'dual': [14], 'antagonizing': [15], 'activity.': [16], '1Etsuo': [17], 'Ohshima,': [18], 'Hitoshi': [19], 'Takami,': [20], 'Hiroyuki': [21, 25], 'Harakawa,': [22], 'Hideyuki': [23], 'Sato,': [24], 'Obase,': [26], 'Ichiro': [27], 'Miki,': [28], 'Akio': [29], 'Ishii,': [30, 32], 'Hidee': [31], 'Yasuo': [33], 'Sasaki,': [34], 'Cite': [36], 'this:': [37], 'J.': [38], 'Med.': [39], 'Chem.': [40], '1993,': [41], '36,': [42], '3,': [43], '417–420Publication': [44], 'Date': [45], '(Print):February': [46], '1,': [47], '1993Publication': [48], 'History': [49], 'Published': [50], 'online1': [51], 'May': [52], '2002Published': [53], 'inissue': [54], '1': [55], 'February': [56], '1993https://pubs.acs.org/doi/10.1021/jm00055a013https://doi.org/10.1021/jm00055a013research-articleACS': [57], 'PublicationsRequest': [58], 'reuse': [59], 'permissionsArticle': [60], 'Views158Altmetric-Citations17LEARN': [61], 'ABOUT': [62], 'THESE': [63], 'METRICSArticle': [64], 'Views': [65], 'are': [66, 89, 102], 'the': [67, 98, 103, 132, 143, 156, 159, 164, 171, 177], 'COUNTER-compliant': [68], 'sum': [69], 'of': [70, 105, 131], 'full': [71], 'text': [72], 'article': [73, 137], 'downloads': [74], 'since': [75], 'November': [76], '2008': [77], '(both': [78], 'PDF': [79], 'HTML)': [81], 'across': [82], 'all': [83], 'institutions': [84], 'individuals.': [86], 'These': [87], 'metrics': [88], 'regularly': [90], 'updated': [91, 115], 'to': [92, 97], 'reflect': [93], 'usage': [94], 'leading': [95], 'up': [96], 'last': [99], 'few': [100], 'days.Citations': [101], 'number': [104], 'other': [106], 'articles': [107], 'citing': [108], 'this': [109], 'article,': [110], 'calculated': [111], 'by': [112], 'Crossref': [113, 121], 'daily.': [116], 'Find': [117, 167], 'more': [118, 168], 'information': [119, 169], 'about': [120, 155], 'citation': [122], 'counts.The': [123], 'Altmetric': [124, 172], 'Attention': [125, 173], 'Score': [126, 174], 'is': [127, 179], 'a': [128, 135, 148], 'quantitative': [129], 'measure': [130], 'attention': [133], 'that': [134], 'research': [136], 'has': [138], 'received': [139], 'online.': [140], 'Clicking': [141], 'on': [142, 170], 'donut': [144], 'icon': [145], 'will': [146], 'load': [147], 'page': [149], 'at': [150], 'altmetric.com': [151], 'with': [152, 187], 'additional': [153], 'details': [154], 'score': [157, 178], 'social': [160], 'media': [161], 'presence': [162], 'for': [163], 'given': [165], 'article.': [166], 'how': [176], 'calculated.': [180], 'Share': [181, 196], 'Add': [182], 'toView': [183], 'InAdd': [184], 'Full': [185], 'Text': [186], 'ReferenceAdd': [188], 'Description': [189], 'ExportRISCitationCitation': [190], 'abstractCitation': [192], 'referencesMore': [194], 'Options': [195], 'onFacebookTwitterWechatLinked': [197], 'InRedditEmail': [198], 'Other': [199], 'access': [200], 'optionsGet': [201], 'e-AlertscloseSupporting': [202], 'Info': [203], '(1)»Supporting': [204], 'Information': [205, 207], 'Supporting': [206], 'Get': [208], 'e-Alerts': [209]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2952184832', 'counts_by_year': [{'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-10T00:16:35.612869', 'created_date': '2019-06-27'}