Title: Linchpin Construction of Unsymmetrical 1,4-Alkynediols
Abstract: A one-pot preparation of unsymmetrical 1,4-alkynediols such as 2a by the coupling of trimethylsilylacetylene and two different aldehydes or ketones is reported. The dilithiated species 5 is generated by the sequential addition of the first aldehyde or ketone 1b to a solution of lithium trimethylsilylacetylide, followed by the addition of methyllithium, which removes the trimethylsilyl protecting group. Addition of the second aldehyde or ketone then leads to the unsymmetrical 1,4-alkynediol 2a.
Publication Year: 2002
Publication Date: 2002-10-24
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 2
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