Publication Information

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'referenced_works': ['https://openalex.org/W1995000641', 'https://openalex.org/W2732168157'], 'related_works': ['https://openalex.org/W4250377796', 'https://openalex.org/W4242583968', 'https://openalex.org/W4211036516', 'https://openalex.org/W2510048479', 'https://openalex.org/W2238787912', 'https://openalex.org/W2158467197', 'https://openalex.org/W2131138669', 'https://openalex.org/W2083083415', 'https://openalex.org/W2064775052', 'https://openalex.org/W1489705104'], 'abstract_inverted_index': {'<h3>Background:</h3>': [0], 'RORγt<sup>+</sup>Foxp3<sup>+</sup>': [1, 64], 'regulatory': [2], 'T': [3, 176, 514], '(Treg)': [4], 'cells,': [5, 17, 146], 'designated': [6], 'as': [7, 53, 500], 'Tr17': [8, 42, 200, 261, 324, 350, 367, 392, 413, 466, 481], 'is': [9], 'one': [10], 'of': [11, 15, 25, 34, 41, 48, 63, 89, 101, 116, 194, 221, 237, 275, 307, 396, 400, 435, 452, 473, 490, 496, 511, 529], 'the': [12, 19, 23, 46, 61, 68, 219, 380, 397, 433, 471, 484, 488, 493], 'new': [13], 'subset': [14], 'Treg': [16, 173], 'having': [18], 'potential': [20, 485], 'to': [21, 388, 440, 455, 486], 'regulate': [22, 487], 'development': [24, 47, 69, 489], 'experimental': [26], 'autoimmune': [27, 50], 'encephalomyelitis': [28], '(EAE)': [29], 'thorough': [30, 492], 'a': [31], 'specific': [32], 'repression': [33], 'Th17': [35, 357], 'mediated': [36], 'inflammation': [37], '(1).': [38], 'The': [39, 99, 192, 235], 'function': [40], 'remain': [43], 'unclear': [44], 'in': [45, 67, 74, 103, 150, 198, 211, 224, 239, 317, 326, 333, 366, 391, 394, 425, 443, 458, 462, 470, 521], 'other': [49, 381], 'diseases': [51], 'such': [52, 499], 'collagen': [54, 92], 'induced': [55], 'arthritis': [56], '(CIA).': [57], '<h3>Objectives:</h3>': [58], 'To': [59], 'clarify': [60], 'role': [62], '(Tr17)': [65], 'cells': [66, 105, 149, 177, 201, 213, 242, 246, 262, 325, 351, 355, 362, 368, 372, 385, 393, 405, 414, 417, 422, 467, 482], 'CIA.': [70, 436], '<h3>Methods:</h3>': [71], '1)': [72, 323], 'Lymphocytes': [73, 158, 293], 'draining': [75, 327], 'lymph': [76, 328], 'node': [77], '(LN)': [78], 'were': [79, 152, 159, 178, 230, 247, 263, 277, 300, 330, 363, 418, 423, 468], 'harvested': [80, 160, 231], 'from': [81, 161, 232, 294, 518], 'C57BL/6': [82, 233], 'mice': [83, 164, 258, 296, 299, 335, 445, 460], 'on': [84, 143, 165, 267, 349], '10': [85, 121, 166, 287], 'days': [86, 122, 167, 268, 288], 'after': [87, 123, 168, 432], 'immunization': [88], 'type': [90, 129], 'II': [91], '(CII)': [93], 'emulsified': [94], 'with': [95, 114, 182, 209, 265, 281, 302, 337, 353, 370, 403, 430, 447], 'complete': [96], "Freund's": [97], 'adjuvant.': [98], 'expression': [100, 142, 193, 236, 346, 399, 495], 'RORγt': [102, 238, 401], 'Foxp3<sup>+</sup>Treg': [104, 241, 421], 'was': [106, 202, 347, 386], 'analyzed': [107, 153, 203, 248, 278], 'by': [108, 154, 204, 249, 320], 'flow': [109, 155, 205, 250], 'cytometry': [110, 206], 'and': [111, 138, 147, 174, 180, 187, 196, 207, 228, 243, 270, 273, 279, 297, 314, 344, 356, 415, 420, 475, 502], 'compared': [112, 208, 336, 352, 369, 402, 429, 446], 'them': [113], 'lymphocytes': [115, 223], 'non-immunized': [117, 338], 'mice.': [118, 234, 284, 339, 449, 464], '2)': [119, 340], 'At': [120, 286], 'CII': [124, 170, 266, 291, 309], 'immunization,': [125], 'C-C': [126], 'chemokine': [127], 'receptor': [128], '6': [130], '(CCR6),': [131], 'CD25,': [132, 342], 'cytotoxic': [133], 'T-lymphocyte': [134], 'antigen': [135], '4': [136], '(CTLA-4),': [137], 'glucocorticoid-induced': [139], 'TNF-receptor': [140], '(GITR)': [141], 'Tr17,': [144], 'RORγt<sup>-</sup>Treg': [145, 354, 371], 'RORγt<sup>+</sup>non-Treg': [148, 416], 'LN': [151, 229, 431], 'cytometry.': [156, 251], '3)': [157, 359], 'Foxp3<sup>IRES-gfp</sup>': [162], 'reporter': [163], 'first': [169, 290], 'immunization.': [171, 292], 'CD4<sup>+</sup>GFP<sup>+</sup>': [172], 'CD4<sup>+</sup>GFP<sup>-</sup>': [175], 'isolated': [179], 'stimulated': [181], 'anti-CD3': [183], 'monoclonal': [184], 'antibody': [185], '(mAb)': [186], 'anti-CD28': [188], 'mAb': [189], '<i>in': [190], 'vitro</i>.': [191], 'IL-10': [195, 360, 501], 'IL-17': [197, 313, 383, 453], 'RORγt<sup>+</sup>GFP<sup>+</sup>': [199], 'that': [210], 'RORγt<sup>-</sup>GFP<sup>+</sup>': [212], 'or': [214, 303], 'RORγt<sup>+</sup>GFP<sup>-</sup>': [215], 'cells.': [216, 358], '4)': [217, 412], 'After': [218], 'induction': [220, 434], 'CIA,': [222], 'inflamed': [225, 426, 478], 'ankle': [226, 427], 'joints': [227, 428], 'both': [240], 'Foxp3<sup>-</sup>': [244], 'non-Treg': [245], '5)': [252, 437], 'Foxp3<sup>cre</sup>RORγt<sup>fl/fl</sup>': [253], '(conditional': [254], 'knock': [255], 'out;': [256], 'cKO)': [257], 'which': [259], 'deficit': [260], 'immunized': [264], '0': [269], '21.': [271], 'Incidence': [272], 'severity': [274], 'CIA': [276, 438, 474, 491], 'compered': [280], 'Foxp3<sup>wt</sup>RORγt<sup>fl/fl</sup>': [282], '(control)': [283], '6)': [285, 450], 'post': [289], 'control': [295, 448, 463], 'cKO': [298, 444, 459], 'cultured': [301], 'without': [304], '100': [305], 'μg/mL': [306], 'denatured': [308], 'for': [310], '72': [311], 'h.': [312], 'IFNγ': [315], 'levels': [316], 'supernatants': [318], 'measured': [319], 'ELISA.': [321], '<h3>Results:</h3>': [322], 'nodes': [329], 'significantly': [331, 364], 'increased': [332, 365, 419, 469], 'CII-immunized': [334], 'CCR6,': [341], 'CTLA-4,': [343], 'GITR': [345], 'elevated': [348], 'producing': [361, 384], '(12.57': [373], '+/-': [374, 407], '1.135,': [375], 'p': [376, 409], '&lt;': [377], '0.001).': [378], 'On': [379], 'hand,': [382], 'tended': [387, 439, 454], 'be': [389, 441, 456], 'decreased': [390, 424], 'spite': [395], 'high': [398, 494], 'RORγt<sup>+</sup>Th17': [404], '(2.376': [406], '0.231,': [408], '=': [410], '0.176).': [411], 'exacerbated': [442], 'Production': [451], 'higher': [457], 'than': [461], '<h3>Conclusion:</h3>': [465], 'course': [472], 'infiltrated': [476], 'into': [477], 'joints.': [479], 'Moreover,': [480], 'had': [483], 'suppressive': [497], 'molecules': [498], 'CTLA-4.': [503], '<h3>Reference</h3>': [504], '[1]': [505], 'Byong-Seok': [506], 'K.': [507], 'et': [508], 'al.': [509], 'Generation': [510], 'RORγt+': [512], 'Antigen-Specific': [513], 'Regulatory': [515], '17': [516], 'Cells': [517], 'Foxp3+': [519], 'Precursors': [520], 'Autoimmunity.': [522], 'Cell': [523], 'Reports.': [524], '2017.': [525], '21,': [526], '195-207': [527], '<h3>Disclosure': [528], 'Interests:</h3>': [530], 'Kotona': [531], 'Furuyama:': [532], 'None': [533, 537, 541, 545, 549, 553], 'declared,': [534, 538, 542, 546, 550, 554], 'Yuya': [535], 'Kondo:': [536], 'Masahiro': [539], 'Yokosawa:': [540], 'Masaru': [543], 'Shimizu:': [544], 'Hiroto': [547], 'Tsuboi:': [548], 'Isao': [551], 'Matsumoto:': [552], 'Takayuki': [555], 'Sumida': [556], 'Grant/research': [557], 'support': [558], 'from:': [559], 'Bristol-Myers': [560, 564], 'Squibb,': [561], 'Speakers': [562], 'bureau:': [563], 'Squibb': [565]}, 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