Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2951187364', 'doi': 'https://doi.org/10.1371/journal.pgen.1005142', 'title': 'Methylation-Sensitive Expression of a DNA Demethylase Gene Serves As an Epigenetic Rheostat', 'display_name': 'Methylation-Sensitive Expression of a DNA Demethylase Gene Serves As an Epigenetic Rheostat', 'publication_year': 2015, 'publication_date': '2015-03-31', 'ids': {'openalex': 'https://openalex.org/W2951187364', 'doi': 'https://doi.org/10.1371/journal.pgen.1005142', 'mag': '2951187364', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25826366', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4380477'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pgen.1005142', 'pdf_url': 'https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005142&type=printable', 'source': {'id': 'https://openalex.org/S103870658', 'display_name': 'PLoS Genetics', 'issn_l': '1553-7390', 'issn': ['1553-7390', '1553-7404'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005142&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018298613', 'display_name': 'Ben P. Williams', 'orcid': 'https://orcid.org/0000-0002-2002-1410'}, 'institutions': [{'id': 'https://openalex.org/I4210157710', 'display_name': 'Whitehead Institute for Biomedical Research', 'ror': 'https://ror.org/04vqm6w82', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ben P. Williams', 'raw_affiliation_strings': ['Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America', 'institution_ids': ['https://openalex.org/I4210157710']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044545932', 'display_name': 'Daniela Pignatta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210157710', 'display_name': 'Whitehead Institute for Biomedical Research', 'ror': 'https://ror.org/04vqm6w82', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniela Pignatta', 'raw_affiliation_strings': ['Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America', 'institution_ids': ['https://openalex.org/I4210157710']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017238073', 'display_name': 'Steven Henikoff', 'orcid': 'https://orcid.org/0000-0002-7621-8685'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven Henikoff', 'raw_affiliation_strings': ['Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America', 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I1344073410']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056282469', 'display_name': 'Mary Gehring', 'orcid': 'https://orcid.org/0000-0003-2280-1522'}, 'institutions': [{'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}, {'id': 'https://openalex.org/I4210157710', 'display_name': 'Whitehead Institute for Biomedical Research', 'ror': 'https://ror.org/04vqm6w82', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Mary Gehring', 'raw_affiliation_strings': ['Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America', 'Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America', 'institution_ids': ['https://openalex.org/I63966007']}, {'raw_affiliation_string': 'Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America', 'institution_ids': ['https://openalex.org/I4210157710']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5056282469'], 'corresponding_institution_ids': ['https://openalex.org/I63966007', 'https://openalex.org/I4210157710'], 'apc_list': {'value': 2655, 'currency': 'USD', 'value_usd': 2655, 'provenance': 'doaj'}, 'apc_paid': {'value': 2655, 'currency': 'USD', 'value_usd': 2655, 'provenance': 'doaj'}, 'fwci': 15.407, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 164, 'citation_normalized_percentile': {'value': 0.99998, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '11', 'issue': '3', 'first_page': 'e1005142', 'last_page': 'e1005142'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10184', 'display_name': 'Molecular Mechanisms of Plant Development and Regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10184', 'display_name': 'Molecular Mechanisms of Plant Development and Regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11247', 'display_name': 'Plant Nutrient Uptake and Signaling Pathways', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12472', 'display_name': 'Plant Responses to Flooding Stress', 'score': 0.9855, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/epigenomics', 'display_name': 'Epigenomics', 'score': 0.7593047}, {'id': 'https://openalex.org/keywords/dna-demethylation', 'display_name': 'DNA demethylation', 'score': 0.75513196}, {'id': 'https://openalex.org/keywords/demethylase', 'display_name': 'Demethylase', 'score': 0.7430138}, {'id': 'https://openalex.org/keywords/rna-directed-dna-methylation', 'display_name': 'RNA-Directed DNA Methylation', 'score': 0.6658437}, {'id': 'https://openalex.org/keywords/gene-expression', 'display_name': 'Gene Expression', 'score': 0.519822}], 'concepts': [{'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.8968802}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.86942667}, {'id': 'https://openalex.org/C121912465', 'wikidata': 'https://www.wikidata.org/wiki/Q3589153', 'display_name': 'Epigenomics', 'level': 5, 'score': 0.7593047}, {'id': 'https://openalex.org/C16824249', 'wikidata': 'https://www.wikidata.org/wiki/Q5205753', 'display_name': 'DNA demethylation', 'level': 5, 'score': 0.75513196}, {'id': 'https://openalex.org/C2781364455', 'wikidata': 'https://www.wikidata.org/wiki/Q2531584', 'display_name': 'Demethylase', 'level': 4, 'score': 0.7430138}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.68571746}, {'id': 'https://openalex.org/C163002167', 'wikidata': 'https://www.wikidata.org/wiki/Q7277124', 'display_name': 'RNA-Directed DNA Methylation', 'level': 5, 'score': 0.6658437}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.57367885}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.5325849}, {'id': 'https://openalex.org/C37080517', 'wikidata': 'https://www.wikidata.org/wiki/Q18353747', 'display_name': 'Epigenetics of physical exercise', 'level': 5, 'score': 0.45487723}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.37610787}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.34069318}], 'mesh': [{'descriptor_ui': 'D029681', 'descriptor_name': 'Arabidopsis Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D057890', 'descriptor_name': 'Epigenomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017360', 'descriptor_name': 'Arabidopsis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029681', 'descriptor_name': 'Arabidopsis Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D029681', 'descriptor_name': 'Arabidopsis Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004251', 'descriptor_name': 'DNA Transposable Elements', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004251', 'descriptor_name': 'DNA Transposable Elements', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018506', 'descriptor_name': 'Gene Expression Regulation, Plant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020868', 'descriptor_name': 'Gene Silencing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018745', 'descriptor_name': 'Genome, Plant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042822', 'descriptor_name': 'Genomic Instability', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D042822', 'descriptor_name': 'Genomic Instability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030821', 'descriptor_name': 'Plants, Genetically Modified', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036226', 'descriptor_name': 'Seedlings', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D036226', 'descriptor_name': 'Seedlings', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D036226', 'descriptor_name': 'Seedlings', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pgen.1005142', 'pdf_url': 'https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005142&type=printable', 'source': {'id': 'https://openalex.org/S103870658', 'display_name': 'PLoS Genetics', 'issn_l': '1553-7390', 'issn': ['1553-7390', '1553-7404'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/332b9bf7d00f43bdb13a03462a613a91', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4380477', 'pdf_url': 'https://europepmc.org/articles/pmc4380477?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/1721.1/97106', 'pdf_url': 'https://dspace.mit.edu/bitstream/1721.1/97106/1/Williams-2015-Methylation-sensitiv.pdf', 'source': {'id': 'https://openalex.org/S4306400425', 'display_name': 'DSpace@MIT (Massachusetts Institute of Technology)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I63966007', 'host_organization_name': 'Massachusetts Institute of Technology', 'host_organization_lineage': ['https://openalex.org/I63966007'], 'host_organization_lineage_names': ['Massachusetts Institute of Technology'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380477', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/015941', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25826366', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pgen.1005142', 'pdf_url': 'https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005142&type=printable', 'source': {'id': 'https://openalex.org/S103870658', 'display_name': 'PLoS Genetics', 'issn_l': '1553-7390', 'issn': ['1553-7390', '1553-7404'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.55, 'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W1779683016', 'https://openalex.org/W1964184380', 'https://openalex.org/W1970145665', 'https://openalex.org/W1972441633', 'https://openalex.org/W1973036268', 'https://openalex.org/W1980741096', 'https://openalex.org/W1993078372', 'https://openalex.org/W1999644599', 'https://openalex.org/W2005019977', 'https://openalex.org/W2005611856', 'https://openalex.org/W2011303868', 'https://openalex.org/W2016246105', 'https://openalex.org/W2016813268', 'https://openalex.org/W2017198614', 'https://openalex.org/W2018249152', 'https://openalex.org/W2019290599', 'https://openalex.org/W2019630339', 'https://openalex.org/W2020173141', 'https://openalex.org/W2026343134', 'https://openalex.org/W2028839461', 'https://openalex.org/W2029687716', 'https://openalex.org/W2041686632', 'https://openalex.org/W2052520388', 'https://openalex.org/W2058446949', 'https://openalex.org/W2064489231', 'https://openalex.org/W2067151470', 'https://openalex.org/W2071758876', 'https://openalex.org/W2072791837', 'https://openalex.org/W2074137164', 'https://openalex.org/W2074520369', 'https://openalex.org/W2083019620', 'https://openalex.org/W2084144075', 'https://openalex.org/W2086491289', 'https://openalex.org/W2087923515', 'https://openalex.org/W2099660828', 'https://openalex.org/W2100771714', 'https://openalex.org/W2101920472', 'https://openalex.org/W2103444581', 'https://openalex.org/W2104468239', 'https://openalex.org/W2107277218', 'https://openalex.org/W2107337799', 'https://openalex.org/W2108031268', 'https://openalex.org/W2116122104', 'https://openalex.org/W2116368818', 'https://openalex.org/W2120611093', 'https://openalex.org/W2123931334', 'https://openalex.org/W2126606466', 'https://openalex.org/W2130535352', 'https://openalex.org/W2132121419', 'https://openalex.org/W2132926880', 'https://openalex.org/W2133377110', 'https://openalex.org/W2135777982', 'https://openalex.org/W2136861504', 'https://openalex.org/W2146058063', 'https://openalex.org/W2147465115', 'https://openalex.org/W2154531054', 'https://openalex.org/W2164438779', 'https://openalex.org/W2164820209', 'https://openalex.org/W2168031748', 'https://openalex.org/W2170964688'], 'related_works': ['https://openalex.org/W4296785489', 'https://openalex.org/W3025976854', 'https://openalex.org/W2585496917', 'https://openalex.org/W2564018357', 'https://openalex.org/W2145561139', 'https://openalex.org/W2114970231', 'https://openalex.org/W2093719956', 'https://openalex.org/W2059124078', 'https://openalex.org/W2031470038', 'https://openalex.org/W1605104953'], 'abstract_inverted_index': {'Genomes': [0], 'must': [1], 'balance': [2, 47], 'active': [3, 28, 66], 'suppression': [4], 'of': [5, 33, 88, 123, 148], 'transposable': [6], 'elements': [7], '(TEs)': [8], 'with': [9], 'the': [10, 72, 106, 137, 146], 'need': [11], 'to': [12, 38, 71, 82, 112, 153], 'maintain': [13], 'gene': [14, 76], 'expression.': [15], 'In': [16], 'Arabidopsis,': [17], 'euchromatic': [18], 'TEs': [19], 'are': [20, 64], 'targeted': [21], 'by': [22, 92, 97], 'RNA-directed': [23], 'DNA': [24, 29, 62, 74, 93, 98], 'methylation': [25, 34, 49, 94, 104, 154], '(RdDM).': [26], 'Conversely,': [27], 'demethylation': [30, 51, 63], 'prevents': [31], 'accumulation': [32], 'at': [35, 67], 'genes': [36], 'proximal': [37, 70, 108], 'these': [39], 'TEs.': [40], 'It': [41], 'is': [42, 53, 90, 110, 125, 132], 'unknown': [43], 'how': [44], 'a': [45, 68], 'cellular': [46], 'between': [48], 'and': [50, 61, 79, 95], 'activities': [52], 'achieved.': [54], 'Here': [55], 'we': [56], 'show': [57], 'that': [58, 102, 136], 'both': [59], 'RdDM': [60, 118], 'highly': [65], 'TE': [69], 'major': [73], 'demethylase': [75, 149], 'ROS1.': [77], 'Unexpectedly,': [78], 'in': [80, 105, 116, 127, 151], 'contrast': [81], 'most': [83], 'other': [84, 128], 'genomic': [85], 'targets,': [86], 'expression': [87, 115, 122], 'ROS1': [89, 107, 114, 124, 138], 'promoted': [91], 'antagonized': [96], 'demethylation.': [99], 'We': [100, 134], 'demonstrate': [101], 'inducing': [103], 'region': [109], 'sufficient': [111], 'restore': [113], 'an': [117, 142], 'mutant.': [119], 'Additionally,': [120], 'methylation-sensitive': [121], 'conserved': [126], 'species,': [129], 'suggesting': [130], 'it': [131], 'adaptive.': [133], 'propose': [135], 'locus': [139], 'functions': [140], 'as': [141], 'epigenetic': [143], 'rheostat,': [144], 'tuning': [145], 'level': [147], 'activity': [150], 'response': [152], 'alterations,': [155], 'thus': [156], 'ensuring': [157], 'epigenomic': [158], 'stability.': [159]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2951187364', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 25}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 25}, {'year': 2019, 'cited_by_count': 23}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 3}], 'updated_date': '2024-09-17T20:32:20.872192', 'created_date': '2019-06-27'}