Title: Synthetic Utility of Catalytic Fe(III)/Fe(II) Redox Cycling Towards Fused Heterocycles: A Facile Access to Substituted Benzimidazole, Bisbenzimidazole and Imidazopyridine Derivatives
Abstract: A catalytic Fe(III)/Fe(II) redox cycling approach has been examined and applied towards synthesis of a wide range of benzimidazole, bis-benzimidazole and imidazopyridine derivatives from oxidative coupling of aromatic ortho-diamines with aromatic as well as heterocyclic aldehydes bearing different types of substituents. This versatile and convenient method has further proven to be particularly useful in expeditiously affording a number of novel bis-benzimidazole class of Hoechst 33 258 analogs towards potential development as fluorescent nucleic acid binding probes. Successful preparation and characterization of a diverse set of thirty different compounds is presented here.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 101
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