Publication Information

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[189, 338, 626, 775, 1000], 'Uppsala,': [190, 339, 627, 776, 1001], 'Li-hua': [199, 201, 636, 638, 911], 'Li': [200, 202, 637, 639], 'Chen': [220, 222, 657, 659, 913], 'Meng': [221, 223, 658, 660], 'Martin': [241, 243, 678, 680, 915], 'Frejno': [242, 244, 679, 681], 'orcid.org/0000-0002-6651-1773': [245, 682], 'Tobias': [263, 265, 700, 702, 917], 'Schmidt': [264, 266, 701, 703], 'Karsten': [284, 286, 721, 723, 919], 'Schnatbaum': [285, 287, 722, 724], 'JPT': [288, 725], 'Peptide': [289, 726, 1004], 'Technologies': [290, 727, 1005], 'Berlin,': [292, 729, 1007], 'Mathias': [301, 303, 348, 350, 738, 740, 785, 787, 921, 925], 'Wilhelm': [302, 304, 739, 741, 1477, 3807], 'Frederik': [322, 324, 759, 761, 923], 'Ponten': [323, 325, 760, 762], 'orcid.org/0000-0003-0703-3940': [326, 763], 'Uhlen': [349, 351, 786, 788], 'Julien': [371, 375, 808, 812, 927], 'Gagneur': [372, 376, 809, 813, 928], 'Corresponding': [373, 402, 422, 810, 839, 859], 'Author': [374, 403, 423, 811, 840, 860, 892], '[email': [377, 406, 426, 814, 843, 863, 1033, 1048, 1063], 'protected]': [378, 407, 427, 815, 844, 864, 1034, 1049, 1064], 'orcid.org/0000-0002-8924-8365': [379, 816], 'Hannes': [400, 404, 837, 841, 930], 'Hahne': [401, 405, 838, 842, 931], 'orcid.org/0000-0003-3601-0051': [408, 845], 'Bernhard': [420, 424, 857, 861, 934], 'Kuster': [421, 425, 858, 862, 935], 'orcid.org/0000-0002-9094-1677': [428, 865], 'Center': [439, 876], 'Integrated': [441, 878, 1011], 'Protein': [442, 879, 1012, 1169, 1347, 1816, 2061], 'Munich': [444, 881, 1014], '(CIPSM),': [445, 882, 1015], 'Information': [893], 'Wang1,‡,': [895], 'Eraslan2,3,‡,': [897], 'Wieland4,': [899], 'Hallström5,': [901], 'Hopf4,': [903], 'Zolg1,': [906], 'Zecha1,': [908], 'Asplund6,': [910], 'Li1,': [912], 'Meng1,': [914], 'Frejno1,': [916], 'Schmidt1,': [918], 'Schnatbaum7,': [920], 'Wilhelm1,': [922], 'Ponten6,': [924], 'Uhlen5,': [926], '*,2,': [929], '*,4': [932], '*,1,8': [936], '1Chair': [937], '2Computational': [947], '3Department': [960], '4OmicScouts': [973], '5Science': [977], '6Science': [989], '7JPT': [1003], '8Center': [1009], '‡These': [1018], 'authors': [1019], 'contributed': [1020], 'equally': [1021], 'to': [1022, 1103, 1106, 1133, 1320, 1340, 1439, 1507, 1510, 1642, 1689, 1776, 1790, 1824, 1857, 2150, 2303, 2323, 2510, 2730, 2845, 2857, 2900, 2980, 2985, 2994, 3189, 3239, 3254, 3329, 3364, 3374, 3475, 3536, 3616, 3736, 3770, 3821, 3823, 3843, 3859, 3935, 4004, 4025, 4057, 4066, 4147, 4281, 4341, 4352], 'work': [1024], '*Corresponding': [1025, 1035, 1050], 'author.': [1026, 1036, 1051], 'Tel:': [1027, 1037, 1052], '+49': [1028, 1038, 1043, 1053, 1058], '89': [1029], '289': [1030], '19411;': [1031], 'E-mail:': [1032, 1047, 1062], '8161': [1039, 1044, 1054, 1059], '976289': [1040, 1045], '0;': [1041], 'Fax:': [1042, 1057], '1;': [1046], '71': [1055, 1060], '5696;': [1056], '5931;': [1061], 'Molecular': [1065], 'Systems': [1066], 'Biology': [1067], '(2019)15:e8503https://doi.org/10.15252/msb.20188503': [1068], 'See': [1069], 'also:': [1070], 'B': [1071], 'et': [1073, 1447, 1474, 1478, 1530, 1534, 1561, 1565, 1608, 1612, 1616, 1719, 1723, 1821, 1846, 1891, 1897, 1949, 2001, 2019, 2120, 2126, 2271, 2326, 3022, 3267, 3568, 3631, 3635, 3639, 3712, 3796, 3800, 3804, 3808, 4322], 'al': [1074, 3023, 3268], '(February': [1075], '2019)': [1076], 'PDFDownload': [1077], 'PDF': [1078], 'article': [1080], 'text': [1081], 'main': [1083], 'figures.': [1084], 'Peer': [1085], 'ReviewDownload': [1086], 'a': [1087, 1153, 1322, 1587, 1644, 1676, 1703, 1754, 1778, 1826, 1991, 2023, 2042, 2071, 2139, 2259, 2338, 2759, 2872, 3011, 3083, 3145, 3157, 3168, 3331, 3395, 3531, 3552, 3681, 3860, 4042, 4050, 4353], 'summary': [1088], 'the': [1090, 1167, 1255, 1280, 1333, 1386, 1398, 1406, 1413, 1457, 1499, 1511, 1516, 1574, 1708, 1727, 1760, 1770, 1785, 1792, 1814, 1834, 1876, 1936, 1945, 2011, 2051, 2091, 2098, 2147, 2155, 2205, 2209, 2219, 2230, 2246, 2249, 2277, 2308, 2333, 2367, 2415, 2418, 2439, 2451, 2461, 2489, 2498, 2531, 2544, 2555, 2559, 2609, 2648, 2653, 2665, 2685, 2721, 2748, 2766, 2773, 2796, 2906, 2910, 2967, 2986, 3017, 3036, 3057, 3079, 3098, 3105, 3175, 3200, 3214, 3217, 3226, 3234, 3240, 3255, 3284, 3303, 3309, 3320, 3335, 3384, 3403, 3446, 3459, 3476, 3510, 3527, 3563, 3589, 3595, 3602, 3605, 3650, 3667, 3675, 3697, 3723, 3737, 3741, 3764, 3777, 3815, 3818, 3825, 3828, 3849, 3856, 3902, 3911, 3924, 3929, 3959, 3961, 3967, 3969, 3975, 4005, 4045, 4068, 4100, 4120, 4138, 4167, 4181, 4189, 4194, 4202, 4211, 4213, 4241, 4267, 4294, 4300, 4330], 'editorial': [1091, 1095], 'decision': [1092, 1096], 'including': [1094, 1181, 1279, 1358, 2146], 'letters,': [1097], 'reviewer': [1098], 'comments': [1099], 'responses': [1102], 'feedback.': [1104], 'ToolsAdd': [1105], 'favoritesDownload': [1107], 'CitationsTrack': [1108], 'CitationsPermissions': [1109], 'ShareFacebookTwitterLinked': [1110], 'InMendeleyWechatReddit': [1111], 'Figures': [1112], '&': [1113, 3493, 4326], 'Info': [1114], 'Abstract': [1115], 'Genome-,': [1116], 'transcriptome-': [1117], 'proteome-wide': [1119], 'measurements': [1120], 'provide': [1121, 1825], 'insights': [1122], 'into': [1123, 3035], 'how': [1124, 1498, 3007, 3776], 'biological': [1125, 3793], 'systems': [1126, 1670], 'are': [1127, 1140, 1146, 1308, 1437, 1505, 1523, 1886, 2174, 2287, 2425, 2497, 2581, 2878, 2919, 3151, 3221, 3357, 3488, 3692, 3991, 4033, 4199, 4244], 'regulated.': [1128], 'However,': [1129, 1568, 1646, 2670, 3108], 'fundamental': [1130, 1400], 'aspects': [1131], 'relating': [1132], 'which': [1134, 1144, 1298, 1312, 2286, 2312, 2350, 2466, 3005, 3032, 3155, 3305, 3391, 3586], 'proteins': [1136, 1180, 1208, 1460, 2104, 2165, 2185, 2235, 2243, 2335, 2363, 2423, 2455, 2483, 2572, 2588, 2604, 2650, 2672, 2719, 2780, 2814, 2834, 2860, 2880, 2961, 3009, 3119, 3143, 3162, 3204, 3230, 3264, 3479, 3705, 3727, 3734, 3885, 4160, 4183, 4238, 4248], 'exist,': [1137], 'where': [1138, 1306, 3608], 'they': [1139, 1307, 2222, 2353, 2895, 3487], 'expressed': [1141, 1204, 1309, 2092, 2426, 2582, 2666, 2680, 2710, 3091, 3491, 3581, 3686, 3726, 3930], 'in': [1143, 1195, 1311, 1394, 1403, 1412, 1515, 1664, 1691, 1715, 1800, 1844, 1854, 1864, 1888, 1969, 2010, 2094, 2105, 2204, 2218, 2225, 2268, 2366, 2409, 2430, 2438, 2447, 2458, 2473, 2484, 2493, 2501, 2537, 2566, 2574, 2579, 2583, 2589, 2594, 2696, 2720, 2753, 2842, 2889, 2898, 2921, 3064, 3067, 3092, 3123, 3165, 3206, 3213, 3233, 3299, 3302, 3317, 3344, 3410, 3419, 3464, 3468, 3582, 3594, 3623, 3649, 3656, 3669, 3773, 3787, 3838, 3848, 3922, 3948, 4093, 4163, 4178, 4232, 4240, 4284, 4314, 4363, 4369], 'quantities': [1145, 1219, 1458, 4275], 'not': [1147, 1198, 1428, 1483, 1494, 1674, 2175, 2374, 2552, 2674, 2789, 2837, 3077, 3358, 3489, 3693], 'fully': [1148], 'understood.': [1149], 'Therefore,': [1150, 1769, 3847], 'we': [1151, 1805, 1838, 2315, 3015, 3248, 3351, 3392, 3499, 3851, 3864], 'generated': [1152, 1550], 'quantitative': [1154, 1325, 1368, 1734, 1925, 3359, 3709], 'paired': [1162, 1958], 'from': [1166, 1668, 1813, 2392, 2771, 2982, 3174, 3719], 'Human': [1168, 1815, 2250], 'Atlas': [1170, 1817], 'project': [1171, 1819, 1947, 2211], 'representing': [1172, 1919, 2070], 'genes': [1174, 1300, 1354, 1411, 1656, 1973, 1984, 2075, 2083, 2402, 2536, 2638, 2770, 3034, 3074, 3089, 3433, 3453, 3629, 3646, 4060, 4197, 4217], '18,072': [1176, 1971], 'transcripts': [1177, 1303, 2421, 2445, 2464, 2481, 2606, 3113, 3138, 3164, 3729, 3872, 4162, 4171, 4177, 4206], '13,640': [1179, 1353, 2074], '37': [1182, 1359, 2164, 2200], 'without': [1183, 2712], 'prior': [1184], 'protein-level': [1185, 2161], 'evidence.': [1186], 'The': [1187, 1330, 2329, 2412, 2433, 2717, 2855, 2957, 3380, 3415, 3752, 3868, 4009, 4135, 4237], 'analysis': [1188, 1711, 1737, 1756, 1907, 2387, 2735, 3170, 3311, 3721, 3854, 4222], 'revealed': [1189, 1623, 3555], 'that': [1190, 1206, 1212, 1226, 1236, 1259, 1388, 1456, 1597, 1751, 1880, 2111, 2173, 2253, 2276, 2372, 2424, 2540, 2607, 2821, 3220, 3273, 3353, 3455, 3478, 3502, 3577, 3601, 3678, 3689, 3730, 3780, 3883, 3908, 3936, 4099, 4109, 4142, 4198, 4249, 4270, 4304], 'hundreds': [1191], 'proteins,': [1193, 1305], 'particularly': [1194, 3947], 'testis,': [1196], 'could': [1197, 1250, 2673], 'be': [1199, 1251, 1277, 1321, 1852, 1882, 2675, 2978, 3190, 3330, 3514, 3771, 3782, 3785, 3957, 4282, 4342], 'detected': [1200, 1253, 1966, 2224, 2365, 2403, 2446, 2454, 2470, 2542, 2553, 2573, 2640, 2649, 2676, 2800, 2839, 3205, 3232, 3343, 3393, 3409, 3873, 3886], 'even': [1201, 2677], 'highly': [1203, 2140, 2679, 2709, 3297], 'mRNAs,': [1205], 'few': [1207, 1655, 2995, 3861], 'show': [1209, 1839, 2216, 2591, 2608, 3010, 3909, 4250], 'tissue-specific': [1210, 3012], 'expression,': [1211], 'strong': [1213], 'differences': [1214, 1514, 1763, 3668, 3710], 'between': [1215, 1764, 3223, 3754, 4357, 4375], 'mRNA': [1216, 1539, 1592, 1625, 1630, 1765, 1786, 2407, 2657, 2687, 2783, 2870, 2911, 2917, 3029, 3748, 3755, 3833, 4111, 4152, 4319, 4339, 4358], 'protein': [1218, 1227, 1256, 1316, 1338, 1363, 1390, 1527, 1555, 1580, 1594, 1713, 1767, 1788, 1795, 1831, 1859, 2027, 2037, 2261, 2405, 2468, 2526, 2556, 2645, 2713, 3106, 3321, 3324, 3333, 3341, 3371, 3385, 3422, 3507, 3574, 3676, 3750, 3757, 3835, 4077, 4091, 4104, 4126, 4149, 4301, 4305, 4308, 4316, 4333, 4361], 'within': [1220, 1463, 4082], 'across': [1222, 1233, 1295, 1342, 1465, 1742, 1833, 2488, 2613, 3509, 3993, 4084, 4229, 4264], 'exist': [1224, 1301], 'expression': [1228, 1284, 1317, 1339, 1364, 1391, 1540, 1714, 1796, 1832, 1860, 2330, 2490, 2550, 2593, 2612, 2658, 2750, 2784, 2912, 3013, 3122, 3187, 3252, 3424, 3450, 3460, 3508, 3528, 3575, 3751, 3758, 3836, 3857, 3965, 4080, 4105, 4112, 4279], 'is': [1229, 1318, 1350, 1365, 1374, 1396, 1416, 1452, 1493, 2108, 2306, 2313, 2436, 2456, 2471, 2785, 3362, 3383, 3579, 3587, 3604, 3680, 3716, 3813, 3940, 3943, 4053, 4065, 4097], 'often': [1230, 1512, 1672], 'stable': [1232], 'than': [1235, 1327, 1370, 1581, 2110, 2548, 2684, 2915, 4063, 4153, 4347], 'transcripts.': [1238, 4008], 'Only': [1239, 3132], '238': [1240], '9,848': [1242], 'amino': [1243, 2266], 'acid': [1244], 'variants': [1245], 'found': [1246, 1319, 1431, 2695, 3328, 3648], 'exome': [1248], 'sequencing': [1249], 'confidently': [1252, 2102], 'at': [1254, 1418, 1784, 2041, 2050, 2168, 2344, 2543, 2554, 2905, 3097, 3104, 3674, 4299], 'level': [1257, 1348, 1789, 2058, 2408, 3100, 4302], 'showing': [1258], 'proteogenomics': [1260, 1799], 'remains': [1261], 'challenging,': [1262], 'needs': [1263, 1378], 'better': [1264, 3483, 3538], 'computational': [1265], 'methods': [1266], 'requires': [1268], 'rigorous': [1269, 1379], 'validation.': [1270], 'Many': [1271], 'uses': [1272, 1879], 'resource': [1275, 1779, 3840], 'can': [1276, 1851, 1881, 2977, 3781], 'envisaged': [1278], 'study': [1281, 1331, 1774, 1793, 2107, 3286, 3554, 3820], 'gene/protein': [1283], 'regulation': [1285, 1863], 'biomarker': [1287], 'specificity': [1288], 'evaluation.': [1289], 'Synopsis': [1290], 'Proteome': [1291, 2251], 'quantification': [1294, 2016], 'reveals': [1297], 'as': [1302, 1551, 1584, 1586, 1633, 1841, 1843, 2117, 2500, 2707, 2809, 2973, 3070, 3072, 3312, 3314, 3394, 3521, 3559, 3642, 3644], 'approximate': [1313], 'quantities.': [1314], 'Tissue-specific': [1315, 1362], 'rare': [1323, 1366], 'rather': [1326, 1369, 1588, 3707], 'qualitative': [1328, 1371], 'characteristic.': [1329, 1372], 'presents': [1332], 'most': [1334, 1399, 1647, 2610, 3411, 3724, 4169, 4204], 'comprehensive': [1335, 1755, 1827], 'date,': [1341], 'tissues.': [1346, 1490, 2399, 2432, 2533, 4095, 4265, 4286], 'evidence': [1349, 1422, 2162, 2714], 'provided': [1351, 2437, 3837, 3979, 4013], '15,257': [1356], 'isoforms,': [1357], 'missing': [1360, 2904], 'proteins.': [1361, 1519, 1679, 2827, 3292, 4048, 4208], 'Proteogenomics': [1373], 'still': [1375], 'challenging': [1376], 'validation': [1380], 'synthetic': [1382, 2189, 2304], 'peptides.': [1383], 'Introduction': [1384], 'Delineating': [1385], 'factors': [1387, 1758, 2807], 'govern': [1389], 'activity': [1393, 2924], 'cells': [1395, 2983], 'among': [1397, 4201], 'research': [1401, 1622, 1869], 'topics': [1402], 'biology.': [1404], 'Although': [1405, 2747], 'number': [1407, 2100, 2562, 2873, 4070, 4195, 4331], 'potential': [1409], 'protein-coding': [1410, 1972, 2134, 2637, 2801], 'genome': [1415, 2093], 'stabilizing': [1417], 'about': [1419, 2337, 3262, 3877, 4186], '20,000,': [1420], 'high-quality': [1421], 'their': [1424, 3659], 'physical': [1425], 'existence': [1426], 'has': [1427, 1482, 1747, 2373, 2755, 3759], 'yet': [1429, 1497, 1750, 2176, 2375], 'been': [1430, 1484, 1549, 1748, 2356, 2376, 2756, 2838, 2965, 3760], 'all': [1433, 1884, 2213, 2320, 2444, 2448, 2538, 2571, 2584, 2614, 3060, 3068, 3087, 3093, 3112, 3118, 3137, 3142, 3345, 3457, 3654, 4094, 4176, 4285, 4380], 'intense': [1435], 'efforts': [1436], 'ongoing': [1438], 'identify': [1440], 'these': [1441, 1649, 1698, 1849, 2199, 2233, 2242, 2362, 2692, 2826, 2832, 2859, 2879, 2960, 4032], 'currently': [1442, 4054], '~13%': [1443], '"missing': [1444], 'proteins"': [1445], '(Omenn': [1446], 'al,': [1448, 1475, 1479, 1531, 1535, 1562, 1566, 1609, 1613, 1617, 1720, 1724, 1822, 1847, 1892, 1898, 1950, 2002, 2020, 2121, 2127, 2272, 2327, 3569, 3632, 3636, 3640, 3713, 3797, 3801, 3805, 3809, 4323], '2017).': [1449, 1567, 1618, 2328, 3810], 'While': [1450, 2097, 3811, 4166, 4266, 4388], 'it': [1451, 1492, 2137, 3361, 3812, 4052, 4064], 'also': [1453, 1572, 2159, 2244, 2836, 3327, 3427, 3588, 3717, 4040], 'generally': [1454], 'accepted': [1455], 'vary': [1461], 'greatly': [1462], 'different': [1466, 2624, 3826, 4271, 4274], 'cell': [1467, 1544, 1659], 'types,': [1468], 'body': [1471, 3512, 3597], 'fluids': [1472], '(Kim': [1473], '2014;': [1476, 1721], '2014),': [1480, 1951], 'analysed': [1485, 1806, 1913, 2398], 'systematically': [1486], 'many': [1488, 1500, 1743, 1855, 1877, 2153, 2708, 2769, 2778, 2975, 3008, 4059], 'Furthermore,': [1491], 'very': [1495, 2560, 2661, 3953], 'clear': [1496], 'anabolic': [1501], 'catabolic': [1503], 'processes': [1504, 2728], 'coordinated': [1506], 'give': [1508, 2617, 4145], 'rise': [1509, 2993, 4146], 'vast': [1513, 3651], 'levels': [1517, 1522, 1595, 2331, 2868, 4081, 4317, 4320, 4359, 4362], 'Messenger': [1520], 'RNA': [1521, 3977, 4124], 'important': [1524, 1605, 1873, 4312], 'determinants': [1525], '(Vogel': [1529], '2010;': [1532], 'Schwanhäusser': [1533, 2018], '2011),': [1536], 'extensive': [1538, 3829], 'maps': [1541], 'types': [1545, 1660], 'have': [1548, 1571, 1683, 1699, 2201, 2355, 2835, 2850, 2964], 'proxies': [1552], 'estimating': [1554], '(GTEx': [1557, 3180], 'Consortium,': [1558, 3181], '2013;': [1559], 'Uhlén': [1560, 2000, 3021], '2015;': [1563, 3633, 3637], 'Thul': [1564], 'other': [1569, 2113, 2703, 2804, 3043, 3061, 3080], 'studies': [1570, 1650], 'highlighted': [1573, 4239], 'much': [1575, 3471, 4055, 4295, 4343], 'higher': [1576, 2547, 2683, 3158, 3926, 4006], 'dynamic': [1577, 3869, 3962, 4101, 4297], 'range': [1578, 2655, 2913, 3870, 3963, 4102, 4298], 'transcript': [1582, 2545, 2643, 3099, 3420, 4079, 4089], 'well': [1585, 1842, 3071, 3313, 3643], 'poor': [1589, 2793, 3377], 'correlation': [1590, 4260], 'suggesting': [1596], 'further': [1598, 1868, 1878, 2296], 'possibly': [1600], 'diverse': [1601], 'regulatory': [1602], 'elements': [1603, 1626], 'play': [1604, 4310], 'roles': [1606, 3661], '(Schwanhäusser': [1607, 4321], '2011;': [1610, 4324], 'Liu': [1611], '2016;': [1614, 3798], 'Franks': [1615, 3803], 'Decades': [1619], 'careful': [1621], 'numerous': [1624], 'affecting': [1627], 'translation': [1628], 'or': [1629, 1639, 1654, 1657, 1661, 1707, 2428, 2803, 2815, 2864, 2891, 3125, 3130, 3376, 3700, 3704, 3728, 3792, 4255], 'stability': [1631, 4309], 'such': [1632, 2116, 2564], 'codon': [1634, 1637], 'usage,': [1635], 'start': [1636], 'context': [1638], 'secondary': [1640], 'structure': [1641], 'name': [1643], 'few.': [1645], 'focussed': [1651, 1701], 'on': [1652, 1702, 1870, 2065, 2077, 2087, 2404, 2641, 3289, 3831], 'single': [1653, 1658, 1704, 1716], 'were': [1662, 1942, 1955, 2186, 2223, 2336, 2364, 2541, 2639, 2694, 2723, 3231, 3426, 3647], 'performed': [1663, 1749], 'model': [1665], 'organisms': [1666], 'distinct': [1667], 'did': [1673], 'cover': [1675, 4058, 4067, 4172], 'lot': [1677], 'Broader': [1680], 'scale': [1681], 'analyses': [1682], 'recently': [1685], 'become': [1686], 'possible': [1687], 'owing': [1688, 2984], 'advances': [1690], 'profiling': [1695, 1782, 1965, 2005, 3030], 'technologies,': [1696], 'but': [1697, 2282, 2551, 3350, 3406, 3434, 3706], 'mostly': [1700], '(disease)': [1705], 'tissue': [1706, 1917, 1986, 2040, 2085, 2144, 2221, 2704, 3236, 3277, 3423, 3447, 3743, 4030, 4365], 'cell-type': [1709], 'resolved': [1710], '(Zhang': [1718], 'Mertins': [1722], '2016).': [1725, 2273, 3495, 3570], 'To': [1726, 1802, 1866, 3003], 'best': [1728], 'our': [1730, 3207, 3250, 3276, 3300, 3503, 3671, 3853], 'knowledge,': [1731], 'no': [1732, 2467, 2702, 2851, 4256], 'broad-scale': [1733], 'integrative': [1736], 'transcriptomes': [1739, 2522], 'proteomes': [1741, 2145, 2149, 2520], 'would': [1752, 2822], 'enable': [1753], 'explaining': [1759], 'experimentally': [1761], 'observed': [1762], 'expression.': [1768], 'purpose': [1771], 'was': [1775, 2063, 2469, 2788, 3090, 3211, 3296, 3306, 3326, 3342, 3372, 3400, 3407, 3470], 'generate': [1777], 'molecular': [1781, 2853], 'data': [1783, 1850, 1885, 1939, 3173, 3243, 3253, 3259, 3288, 3301, 3337, 3830, 3858, 3978, 4011], 'facilitate': [1791, 1867], 'control': [1797], 'humans.': [1801, 1865], 'end,': [1804], 'major': [1808, 1920, 3590, 3606], 'histologically': [1809, 1915], '(HPA)': [1818], '(Uhlén': [1820], '2015)': [1823, 1893, 3641], 'baseline': [1828, 3504], 'map': [1829, 2396, 3505, 3572], 'body.': [1836], 'As': [1837, 4049, 4291], 'below': [1840, 2341, 2966], '2019,': [1848], 'used': [1853, 1956], 'ways': [1856], 'explore': [1858, 3004], 'its': [1862, 3611], 'fundamentally': [1872], 'topic': [1874], 'envisaged,': [1883], 'available': [1887, 3212], 'ArrayExpress': [1889], '(Kolesnikov': [1890], 'proteomeXchange': [1895], '(Vizcaíno': [1896], '2014).': [1899], 'Results': [1900], 'Discussion': [1902], 'Comprehensive': [1903, 2383], 'transcriptomic': [1904, 2386], 'proteomic': [1906, 2384], 'We': [1912, 2274], 'specimen': [1918], 'organs': [1922], 'label-free': [1924], 'proteomics': [1926], 'RNA-Seq': [1928, 1964, 3172, 3875, 3933, 4062], '(Fig': [1929, 1987, 2059, 2668, 2715, 3195, 3439, 3744, 3895], '1A;': [1930], 'see': [1931, 3897, 4115], 'Appendix': [1932, 3280, 3898, 4116, 4385], 'Figs': [1933, 3281], 'S1–S6': [1934], 'assessment': [1937], 'quality).': [1940], 'Tissues': [1941], 'collected': [1943], 'HPA': [1946, 2210, 3176, 3224], '(Fagerberg': [1948], 'adjacent': [1953], 'cryosections': [1954], '(allele-specific)': [1959], 'analysis.': [1963], 'quantified': [1968], 'total': [1970, 2024, 2072, 2099, 3201, 4190], 'with': [1974, 2029, 2263, 2546, 2781, 2817, 3167, 3184, 3275, 3435, 3658, 4000, 4041], 'an': [1975, 2030, 2237, 2370, 3560, 3720, 4001, 4311], 'average': [1976, 2031, 2549, 3058], '12,262': [1978], '(±': [1979, 2034, 2080], '1,007': [1980], 'standard': [1981], 'deviation,': [1982], 'SD)': [1983, 2036, 2082], 'per': [1985, 1996, 2039, 2084, 3985, 4029, 4151, 4336], '1B)': [1988], 'when': [1989], 'using': [1990, 3905], 'cut-off': [1992], '1': [1994], 'fragment': [1995], 'kilobase': [1997], 'million': [1998], '(FPKM;': [1999], '2015).': [2003], 'Proteomic': [2004], 'mass': [2007, 2862, 2968, 3241, 3888, 3949, 4022], 'spectrometry': [2008, 2863, 3889], 'resulted': [2009], 'identification': [2012, 2062], 'intensity-based': [2014], 'absolute': [2015, 2478], '(iBAQ;': [2017], '2011)': [2021], '15,210': [2026], 'groups': [2028, 2038, 2527], '11,005': [2033], '680': [2035], 'false': [2043], 'discovery': [2044, 3520], 'rate': [2045], '(FDR)': [2046], '<': [2048], '1%': [2049], 'protein,': [2052], 'peptide': [2053], 'peptide-spectrum': [2055], 'match': [2056, 3078], '(PSM)': [2057], 'EV1A).': [2060], 'based': [2064], '277,698': [2066], 'non-redundant': [2067], 'tryptic': [2068, 2999], 'peptides,': [2069], 'and,': [2076], 'average,': [2078, 2088], '10,541': [2079], '512': [2081], 'covering,': [2086], '86%': [2089], 'every': [2095, 4364], 'tissue.': [2096, 2411, 2615, 3986, 4134], 'identified': [2103, 2525, 4020], 'smaller': [2109], '(community-based)': [2114], 'resources': [2115], 'ProteomicsDB': [2118], '(Schmidt': [2119], '2018)': [2122], 'neXtProt': [2124, 2179], '(Gaudet': [2125], '2017;': [2128, 3802, 3806], 'coverage': [2129, 2663, 2794, 3927], '15,721': [2131], '17,470': [2133], 'genes,': [2135, 3458], 'respectively),': [2136], 'provides': [2138, 2160], 'consistent': [2141], 'collection': [2142], 'deepest': [2148], 'date': [2151], 'analysed.': [2157], 'It': [2158, 4096], '(represented': [2166], 'least': [2169, 3921], 'one': [2170, 3124, 3522], 'unique': [2171], 'peptide)': [2172], 'covered': [2177], '(release': [2180], '2018-01-17;': [2181], 'Table': [2182, 3441, 3746, 3914], 'EV1).': [2183], 'These': [2184], 'validated': [2187], 'peptides': [2190, 2257, 2305, 3000, 4017], '(see': [2191, 3279], 'PRIDE': [2192, 2324], 'submission': [2193], 'mirror': [2195, 2317], 'spectra).': [2196], 'Eighteen': [2197], 'antibody': [2202, 3209, 3315, 3348, 3378], 'staining': [2203, 3210, 3316, 3349], 'current': [2206, 3227, 3819], 'release': [2207], 'them': [2215], 'signal': [2217], 'same': [2220, 2499, 3235, 3912, 4069], 'MS.': [2227], 'This': [2228, 2787, 3340, 3715, 3916, 3939], 'corroborates': [2229], 'detection': [2231, 2824, 2970, 3368], 'new': [2234, 2260], 'independent': [2238], 'method.': [2239], 'Eight': [2240], 'meet': [2245], 'guidelines': [2247, 2279], 'Project': [2252], 'require': [2254], '≥': [2255, 2264], '2': [2256], 'each': [2262, 2410, 2529], '9': [2265], 'acids': [2267], 'length': [2269], '(Deutsch': [2270], 'note': [2275, 3352], 'HPP': [2278], 'use': [2280], 'reasonable': [2281], 'ad': [2283], 'hoc': [2284], 'criteria': [2285], 'likely': [2288, 2293, 2307], 'too': [2289], 'conservative': [2290], 'therefore': [2292], 'discriminate': [2294], 'against': [2295], 'genuine': [2297], 'cases.': [2298], 'Comparing': [2299], 'spectra': [2300, 4023], 'endogenous': [2302], 'objective': [2310], 'criterion': [2311], 'why': [2314, 2352], 'added': [2316], 'plots': [2318], 'evaluated': [2321], 'cases': [2322, 2565], '(Zolg': [2325], '"new"': [2334], 'factor': [2339], '10': [2340, 3271, 3900, 4168], 'median': [2342], '(iBAQ': [2343, 4106], 'log10': [2345, 4227], 'scale,': [2346], '7.4': [2347], 'versus': [2348], '8.3)': [2349], 'explains': [2351, 3919], 'may': [2354, 2962, 3480, 3513, 3784], 'missed': [2357], 'before.': [2358], 'Interestingly,': [2359, 2828], '15': [2360], 'fallopian': [2368], 'tube,': [2369], 'organ': [2371], 'extensively': [2377, 3762], 'profiled': [2378], 'proteomics.': [2380], 'Figure': [2381, 2514, 4073], '1.': [2382], 'donors': [2394], 'Body': [2395], 'Number': [2400, 2523, 2534], 'colouring': [2413], 'bars': [2416], 'indicates': [2417, 4141, 4269], 'fractions': [2419], 'everywhere': [2427], 'enriched': [2429, 2726], 'certain': [2431], 'full': [2434], 'classification': [2435, 3018], 'text.': [2440], 'Abundance': [2441, 2568], 'distribution': [2442, 2476, 2569, 3448], '(grey);': [2450], 'fraction': [2452, 2462, 3085, 4214], 'shown': [2457, 2472, 2492], 'blue': [2459, 2580], 'orange.': [2474], 'Relative': [2475], 'numbers': [2479, 3907], 'selected': [2485], 'functional': [2486, 3430, 3738], 'classes': [2487, 3038], 'categories': [2491, 3431], 'panel': [2494, 2502, 3278, 4243], '(B).': [2495, 2503], 'Colours': [2496], 'Download': [2504, 2506, 2631, 2633, 4287, 4289], 'figure': [2505, 2632, 4288], 'PowerPoint': [2507, 2634, 4290], 'Click': [2508], 'here': [2509], 'expand': [2511], 'figure.': [2513], 'EV1.': [2515], 'Further': [2516], 'characterization': [2517], 'level.': [2557, 3107], 'Note': [2558], 'high': [2561, 2782, 2867, 4251], 'testis.': [2567], 'brain': [2576, 3152, 4133, 4373], '(grey).': [2577], 'Proteins': [2578, 2903, 3183], 'tissues,': [2586, 4230, 4382], 'orange': [2590], 'elevated': [2592, 3121], 'brain.': [2595], 'Clustering': [2596], 'gene': [2598, 2733], 'ontology': [2599, 2734], 'terms': [2600, 2621, 3774, 3788], '(biological': [2601], 'process)': [2602], 'divergent': [2611], 'Boxes': [2616], 'examples': [2618], 'GO': [2620], 'four': [2623, 3878], '(Appendix,': [2626], 'brain,': [2627], 'heart': [2628, 3304], 'testis).': [2630], 'Overall,': [2635, 3082], '13,413': [2636], 'both': [2642, 3832], 'levels,': [2646, 3619], 'spanned': [2651, 3876, 3890], 'almost': [2652, 2829, 4173, 4233], 'entire': [2654], 'again': [2659, 3408], 'indicating': [2660, 3600], 'substantial': [2662], '1C).': [2669], 'some': [2671, 3436], 'mRNAs': [2681, 2693, 2711, 2752, 3703, 4144], '(i.e.': [2682], 'mean': [2686, 2916], 'abundance).': [2688], 'About': [2689], '1/3': [2690], 'testis': [2697, 2722, 2754, 2779, 2797, 2843, 2890, 3154], '(478': [2698], '1,408)': [2700], 'contained': [2705], 'nearly': [2706, 2848, 4354], 'EV1B).': [2716], '"missing"': [2718, 2833], 'statistically': [2724], 'significantly': [2725], 'related': [2729, 3735], 'spermatogenesis': [2731], '(clusterProfiler;': [2736], 'n': [2737], '=': [2738, 2743, 2926, 2930, 2937, 2941, 2949, 2953], '82': [2739], 'genes;': [2740], 'BH-adjusted': [2741, 2928, 2939, 2951], 'P': [2742, 2929, 2940, 2952], '8': [2744], '×': [2745, 2932, 2943, 2955], '10−14).': [2746], 'rich': [2749], 'known': [2757], 'long': [2760], 'time': [2761], 'exploited': [2763], 'for,': [2764], 'e.g.,': [2765, 2792, 3524], 'cloning': [2767], 'cDNAs,': [2772], 'apparent': [2774, 4098], 'absence': [2775, 3701], 'so': [2777, 3360], 'surprising.': [2786], 'due': [2790, 3373], 'to,': [2791], '(11,024': [2799], 'genes)': [2802], 'obvious': [2805], 'technical': [2806, 3790], '(such': [2808], 'inefficient': [2810], 'extraction': [2811], 'membrane': [2813], 'difficulties': [2816], 'identifying': [2818], 'small': [2819], 'proteins)': [2820], 'prevent': [2823], '300': [2830], 'antibodies': [2841, 2865], '(according': [2844], 'HPA)': [2846], '200': [2849], 'ascribed': [2852], 'function.': [2854], 'inability': [2856], 'detect': [2858], 'despite': [2866], 'poses': [2871], 'questions.': [2875], 'For': [2876, 3197, 3443, 3550, 3973], 'example,': [2877, 3444, 3974], 'rapidly': [2881], 'degraded': [2882], 'implying': [2883], 'specialized': [2884], '(and': [2885, 3584], 'perhaps': [2886, 2896], 'transient)': [2887], 'functions': [2888], 'sperm': [2892], 'functionality?': [2893], 'Are': [2894], 'stabilized': [2897], 'response': [2899], 'egg': [2901], 'fertilization?': [2902], 'lower': [2907, 3193, 3968], 'end': [2908], '(less': [2914], 'abundance)': [2918], 'overrepresented': [2920], 'G-protein-coupled': [2922], 'receptor': [2923], '(n': [2925, 2936, 2948], '173;': [2927], '8.3': [2931], '10−50),': [2933], 'ion': [2934], 'channels': [2935], '109;': [2938], '7': [2942], '10−10)': [2944], 'cytokine-related': [2946], 'biology': [2947], '76;': [2950], '6': [2954], '10−9).': [2956], 'simply': [2963], 'spectrometric': [2969], 'limit': [2971], 'or,': [2972], 'described': [2974], 'times,': [2976], 'difficult': [2979, 3363], 'extract': [2981], 'presence': [2987, 3699], 'multi-pass': [2989], 'transmembrane': [2990], 'domains': [2991], 'giving': [2992], 'if': [2996, 3366, 3486], 'any': [2997, 3042, 3049], 'MS-compatible': [2998], 'after': [3001], 'digestion.': [3002], 'profile,': [3014], 'applied': [3016], 'scheme': [3019], '(2015,': [3024], '2016)': [3025], 'previously': [3026], 'developed': [3027], 'stratifies': [3033], 'five': [3037], '"tissue-enriched"': [3039], '(fivefold': [3040, 3047, 3055], 'above': [3041, 3048, 3056, 3416], 'tissue),': [3044], '"group': [3045], 'enriched"': [3046], 'group': [3050], '2–7': [3052], 'tissues),': [3053, 3062], '"enhanced"': [3054], '"expressed': [3063], 'all"': [3065], '(expressed': [3066], 'tissues)': [3069], '"mixed"': [3073], '(which': [3075], 'do': [3076], 'categories).': [3081], 'large': [3084], 'represented': [3088], 'tissues:': [3094], '37%': [3095], '(6,725)': [3096], '39%': [3102], '(5,400)': [3103], '43%': [3109], '(7,866)': [3110], '53%': [3115], '(7,244)': [3116], 'showed': [3120, 3144], '("tissue-enriched",': [3128], '"group-enriched"': [3129], '"tissue-enhanced").': [3131], '0.73%': [3133], '(on': [3134, 3980, 4014], 'average)': [3135, 3981, 4015], '0.65%': [3140], 'tissue-enriched': [3146, 3161, 3203, 3251, 3291, 3298], 'profile.': [3147], 'Two': [3148], 'notable': [3149], 'exceptions': [3150], 'exhibit': [3156], 'percentage': [3159], 'line': [3166, 3657, 4140], 'recent': [3169, 3553], 'GTEx': [3178], 'projects': [3179], '2013).': [3182, 3714], 'tissue-restricted': [3186, 3473], 'tended': [3188], 'slightly': [3192], 'EV1C).': [3196], '1,270': [3198], '1,998': [3202], 'study,': [3208, 3228], 'HPA.': [3215, 3318], 'In': [3216, 3246, 3496, 3626], 'common': [3222], '775': [3229], 'lending': [3237], 'support': [3238], 'spectrometry-based': [3242], 'presented': [3244], 'here.': [3245], 'addition,': [3247], 'compared': [3249, 3934], 'targeted': [3256], 'MS': [3257, 4010], '(PRM)': [3258], 'acquired': [3260], '52': [3263], 'Edfors': [3266], '(2016)': [3269], 'overlapped': [3274], 'S7–S9).': [3282], 'Incidentally,': [3283], "Edfors'": [3285], 'had': [3287], 'three': [3290], 'First,': [3293], 'myoglobin': [3294], '(MB)': [3295], 'confirmed': [3307, 3338, 3401], 'PRM': [3310, 3336, 3404], 'Second,': [3319], 'PDK1': [3322], '(3-phosphoinositide-dependent': [3323], 'kinase-1)': [3325], 'heart-enriched': [3332], 'this.': [3339], 'immunohistochemistry': [3354], '(IHC)': [3355], 'stains': [3356], 'conclude': [3365], 'broad': [3367], 'overstaining': [3375], 'specificity.': [3379], 'third': [3381], 'example': [3382], 'CANT1': [3386], '(soluble': [3387], 'calcium-activated': [3388], 'nucleotidase': [3389], '1)': [3390], 'prostate-enriched': [3396], 'protein.': [3397, 4191], 'Again,': [3398], 'measurement': [3405], 'IHC.': [3414], 'global': [3417, 4088], 'trends': [3418], 'distributions': [3425], 'mirrored': [3428], 'interesting': [3437], 'detail': [3438], '1D,': [3440], 'EV4).': [3442], 'while': [3445], 'disease-associated': [3452], 'followed': [3454], 'drug': [3462, 3484, 3519], 'targets': [3463, 3485], 'general': [3465, 3516], 'GPCRs': [3467], 'particular': [3469, 3532], 'speaking': [3474], 'notion': [3477], 'make': [3481], 'ubiquitously': [3490, 3685], '(Hao': [3492], 'Tatonetti,': [3494], 'context,': [3498], 'point': [3500], 'out': [3501], 'value': [3517], 'can,': [3523], 'quickly': [3525], 'examine': [3526], 'profile': [3529], 'target': [3533], 'interest,': [3535], 'help': [3537, 3842], 'understand': [3539], 'adverse': [3540], 'clinical': [3541], 'effects': [3542], 'off-target': [3544, 3561], 'mechanisms': [3545], 'action': [3547], 'drugs.': [3549], 'instance,': [3551], 'phenylalanine': [3556], 'hydroxylase': [3557], '(PAH)': [3558], 'pan-HDAC': [3564], 'inhibitor': [3565], 'panobinostat': [3566, 3609], '(Becher': [3567], 'Our': [3571], 'shows': [3576, 3731], 'PAH': [3578], 'abundantly': [3580], 'liver': [3583, 3603], 'kidney)': [3585], 'site': [3591, 3607], 'hydroxylation': [3593], '(Matthews,': [3598], '2007),': [3599], 'exerts': [3610], 'detrimental': [3612], 'effects,': [3613], 'i.e.': [3614], 'leading': [3615, 4351], 'decreased': [3617], 'tyrosine': [3618], 'eventually': [3621, 3844], 'hypothyroidism': [3622], 'affected': [3624], 'patients.': [3625], 'contrast,': [3627], 'essential': [3628], '(Blomen': [3630], 'Hart': [3634], 'mitochondrial': [3645], 'majority': [3652], 'central': [3660], 'maintaining': [3663], 'cellular': [3664], 'homeostasis.': [3665], 'Despite': [3666], 'detail,': [3670], 'dataset': [3672], 'confirms,': [3673], 'level,': 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3894, 3997, 4039], 'eight': [3891, 4036], '2A;': [3896], 'Fig': [3899, 4117, 4370, 4383, 4386], 'corresponding': [3903, 4121, 4182], 'plot': [3904, 4122, 4131, 4158], 'copy': [3906, 4127], 'essentially': [3910], 'characteristics;': [3913], 'EV5).': [3915], 'difference': [3917], 'alone': [3918], '(at': [3920], 'part)': [3923], 'overall': [3925], 'LC-MS/MS.': [3938, 4072], 'because': [3941], 'limited': [3944], '"sequencing': [3945], 'capacity"': [3946], 'spectrometry.': [3950], 'Thus,': [3951], 'detecting': [3952], 'low-abundance': [3954, 4154, 4349], 'molecules': [3955, 4334], 'will': [3956], 'harder,': [3958], 'wider': [3960, 4296], 'sampling': [3970], 'depth': [3971], 'is.': [3972], '(paired-end)': [3976], '18': [3982, 3988], 'M': [3983, 3989], 'reads': [3984, 3990], 'Those': [3987], 'distributed': [3992, 4034], '4': [3994], 'inevitable': [4002], 'bias': [4003, 4043], 'abundant': [4007, 4047, 4170, 4205], 'only': [4012, 4184], '~76,000': [4016], '~284,000': [4019], 'tandem': [4021], 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